DE Unsupervised - gender corrected
Mafe Senosain
5/6/2020
Pre-processing of the data
ls_preprocessed <- preprocess_rna(path_rnaseq = 'rnaseq.RData', correct_batch = T, correct_gender = T)
x <- data.frame(ls_preprocessed$vsd_mat)
x <- cbind('ID'=rownames(x), x)
#x <- cbind('ID'=ls_preprocessed$rna_all$Feature_gene_name, x)
#write.table(x, file = "vst_normed.txt", sep = "\t", row.names = F, quote = F)Exploring data
Batch effect correction
print(ls_preprocessed$pbatch_bf)
print(ls_preprocessed$pgender_bf)
print(ls_preprocessed$pbatch_af)
print(ls_preprocessed$pgender_af)
Using all genes
names(ls_preprocessed)## [1] "p_all" "rna_all" "pData_rnaseq" "counts_all" "vsd_mat"
## [6] "pbatch_bf" "pgender_bf" "pbatch_af" "pgender_af"dim(ls_preprocessed$vsd_mat)## [1] 37983 78corr_pt <- Hmisc::rcorr(ls_preprocessed$vsd_mat, type = 'spearman')
Heatmap(corr_pt$r, name = "mat",
#column_km = 3,
#row_km = 3,
heatmap_legend_param = list(color_bar = "continuous"),
row_names_gp = gpar(fontsize = 8),
column_names_gp = gpar(fontsize = 8))
# Hierarchical clustering
d <- dist(corr_pt$r)
hc1 <- hclust(d)
plot(hc1, cex = 0.6, hang = -1)
#clustering
k <- 4
hc1 <- hclust(d, method = 'complete')
hc2 <- hclust(d, method = 'average')
hc3 <- hclust(d, method = 'mcquitty')
hc4 <- hclust(d, method = 'ward.D')
sub_grp1 <- cutree(hc1, k = k)
sub_grp2 <- cutree(hc2, k = k)
sub_grp3 <- cutree(hc3, k = k)
sub_grp4 <- cutree(hc4, k = k)
kmns <- kmeans(corr_pt$r, centers = k)
clusters <- as.data.frame(cbind(Vantage_ID=names(sub_grp1),
hclust_com=sub_grp1,
hclust_ave=sub_grp2,
hclust_mq=sub_grp3,
hclust_w=sub_grp4,
k_means = kmns$cluster))
ha = rowAnnotation(
hclust_com = as.factor(clusters$hclust_com),
hclust_ave = as.factor(clusters$hclust_ave),
hclust_mq = as.factor(clusters$hclust_mq),
hclust_w = as.factor(clusters$hclust_w),
k_means = as.factor(clusters$k_means),
simple_anno_size = unit(0.5, "cm")
)
Heatmap(corr_pt$r, name = "mat",
heatmap_legend_param = list(color_bar = "continuous"),
row_names_gp = gpar(fontsize = 8),
column_names_gp = gpar(fontsize = 8), right_annotation = ha)
p_all_cl <- ls_preprocessed$p_all
p_all_cl <- p_all_cl %>%
inner_join(., clusters, "Vantage_ID") %>%
mutate_all(as.character)## Warning: Column `Vantage_ID` joining character vector and factor, coercing into
## character vectorDE analysis
k_12 <- which(p_all_cl$hclust_com %in% c('1', '2'))
k_123 <- which(p_all_cl$hclust_com %in% c('1', '2', '3'))
p_all_cl_12 <- p_all_cl
p_all_cl_12$hclust_com[k_12] <- '12'
p_all_cl_123 <- p_all_cl
p_all_cl_123$hclust_com[k_123] <- '123'
DE_res_1v2 <- DE_analysis(ls_preprocessed,
GeneBased=FALSE,
pDataBased=FALSE,
NewCondition=TRUE,
NewCondition_df = p_all_cl,
cond_nm='hclust_com',
two_levels=c('1','2'),
reference = '1',
correct_gender=TRUE)## Unlist done## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender hclust_com hclust_ave hclust_mq hclust_w
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1
## # … with 68 more rows, and 1 more variable: k_means <chr>
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## # … with 68 more rows
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## # … with 68 more rows
## # A tibble: 62 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 6 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 7 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 8 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 9 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## 10 R3388_YZ_… 12323 1 Female 2 1 1 1 4
## # … with 52 more rows## Labeling done## Filtering done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Design done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## Warning: Setting row names on a tibble is deprecated.## vsd symbols done## using pre-existing size factors## estimating dispersions## gene-wise dispersion estimates## mean-dispersion relationship## final dispersion estimates## fitting model and testing## -- replacing outliers and refitting for 1301 genes
## -- DESeq argument 'minReplicatesForReplace' = 7
## -- original counts are preserved in counts(dds)## estimating dispersions## fitting model and testing## DESeq done## using 'normal' for LFC shrinkage, the Normal prior from Love et al (2014).
##
## Note that type='apeglm' and type='ashr' have shown to have less bias than type='normal'.
## See ?lfcShrink for more details on shrinkage type, and the DESeq2 vignette.
## Reference: https://doi.org/10.1093/bioinformatics/bty895## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## res symbols done## list doneDE_res_3v1 <- DE_analysis(ls_preprocessed,
GeneBased=FALSE,
pDataBased=FALSE,
NewCondition=TRUE,
NewCondition_df = p_all_cl,
cond_nm='hclust_com',
two_levels=c('3','1'),
reference = '3',
correct_gender=TRUE)## Unlist done## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender hclust_com hclust_ave hclust_mq hclust_w
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1
## # … with 68 more rows, and 1 more variable: k_means <chr>
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## # … with 68 more rows
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## # … with 68 more rows
## # A tibble: 34 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 5 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 6 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 7 R3388_YZ_… 11538 1 Male 3 1 1 3 3
## 8 R3388_YZ_… 15626 1 Female 3 1 2 2 3
## 9 R3388_YZ_… 15467 1 Female 1 1 1 1 1
## 10 R3388_YZ_… 12929 1 Female 3 1 1 3 3
## # … with 24 more rows## Labeling done## Filtering done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Design done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## Warning: Setting row names on a tibble is deprecated.## vsd symbols done## using pre-existing size factors## estimating dispersions## gene-wise dispersion estimates## mean-dispersion relationship## final dispersion estimates## fitting model and testing## -- replacing outliers and refitting for 1650 genes
## -- DESeq argument 'minReplicatesForReplace' = 7
## -- original counts are preserved in counts(dds)## estimating dispersions## fitting model and testing## DESeq done## using 'normal' for LFC shrinkage, the Normal prior from Love et al (2014).
##
## Note that type='apeglm' and type='ashr' have shown to have less bias than type='normal'.
## See ?lfcShrink for more details on shrinkage type, and the DESeq2 vignette.
## Reference: https://doi.org/10.1093/bioinformatics/bty895## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## res symbols done## list doneDE_res_3v2 <- DE_analysis(ls_preprocessed,
GeneBased=FALSE,
pDataBased=FALSE,
NewCondition=TRUE,
NewCondition_df = p_all_cl,
cond_nm='hclust_com',
two_levels=c('3','2'),
reference = '3',
correct_gender=TRUE)## Unlist done## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender hclust_com hclust_ave hclust_mq hclust_w
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1
## # … with 68 more rows, and 1 more variable: k_means <chr>
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## # … with 68 more rows
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 1 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 1 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 1 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 1 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 1 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## # … with 68 more rows
## # A tibble: 54 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_4 11652 1 Male 2 1 1 1 3
## 2 R3388_YZ_5 11855 1 Male 2 1 1 1 4
## 3 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 4 R3388_YZ_9 13155 1 Male 2 1 1 1 4
## 5 R3388_YZ_… 11561 1 Male 2 1 1 1 1
## 6 R3388_YZ_… 11538 1 Male 3 1 1 3 3
## 7 R3388_YZ_… 12323 1 Female 2 1 1 1 4
## 8 R3388_YZ_… 13317 1 Male 2 1 1 3 3
## 9 R3388_YZ_… 15626 1 Female 3 1 2 2 3
## 10 R3388_YZ_… 15506 1 Female 2 1 1 3 4
## # … with 44 more rows## Labeling done## Filtering done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Design done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## Warning: Setting row names on a tibble is deprecated.## vsd symbols done## using pre-existing size factors## estimating dispersions## gene-wise dispersion estimates## mean-dispersion relationship## final dispersion estimates## fitting model and testing## -- replacing outliers and refitting for 1335 genes
## -- DESeq argument 'minReplicatesForReplace' = 7
## -- original counts are preserved in counts(dds)## estimating dispersions## fitting model and testing## DESeq done## using 'normal' for LFC shrinkage, the Normal prior from Love et al (2014).
##
## Note that type='apeglm' and type='ashr' have shown to have less bias than type='normal'.
## See ?lfcShrink for more details on shrinkage type, and the DESeq2 vignette.
## Reference: https://doi.org/10.1093/bioinformatics/bty895## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## res symbols done## list doneDE_res_3v12 <- DE_analysis(ls_preprocessed,
GeneBased=FALSE,
pDataBased=FALSE,
NewCondition=TRUE,
NewCondition_df = p_all_cl_12,
cond_nm='hclust_com',
two_levels=c('3','12'),
reference = '3',
correct_gender=TRUE)## Unlist done## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender hclust_com hclust_ave hclust_mq hclust_w
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 12 1 1 1
## 2 R3388_YZ_2 11646 1 Male 12 1 1 1
## 3 R3388_YZ_3 11820 1 Male 12 1 1 1
## 4 R3388_YZ_4 11652 1 Male 12 1 1 1
## 5 R3388_YZ_5 11855 1 Male 12 1 1 1
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2
## 7 R3388_YZ_7 12994 1 Male 12 1 1 1
## 8 R3388_YZ_9 13155 1 Male 12 1 1 1
## 9 R3388_YZ_… 13014 1 Female 12 1 1 1
## 10 R3388_YZ_… 11561 1 Male 12 1 1 1
## # … with 68 more rows, and 1 more variable: k_means <chr>
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 12 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 12 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 12 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 12 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 12 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 12 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 12 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 12 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 12 1 1 1 1
## # … with 68 more rows
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 12 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 12 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 12 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 12 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 12 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 12 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 12 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 12 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 12 1 1 1 1
## # … with 68 more rows
## # A tibble: 75 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 12 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 12 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 12 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 12 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 12 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 3 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 12 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 12 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 12 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 12 1 1 1 1
## # … with 65 more rows## Labeling done## Filtering done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Design done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## Warning: Setting row names on a tibble is deprecated.## vsd symbols done## using pre-existing size factors## estimating dispersions## gene-wise dispersion estimates## mean-dispersion relationship## final dispersion estimates## fitting model and testing## -- replacing outliers and refitting for 1525 genes
## -- DESeq argument 'minReplicatesForReplace' = 7
## -- original counts are preserved in counts(dds)## estimating dispersions## fitting model and testing## DESeq done## using 'normal' for LFC shrinkage, the Normal prior from Love et al (2014).
##
## Note that type='apeglm' and type='ashr' have shown to have less bias than type='normal'.
## See ?lfcShrink for more details on shrinkage type, and the DESeq2 vignette.
## Reference: https://doi.org/10.1093/bioinformatics/bty895## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## res symbols done## list doneDE_res_4v123 <- DE_analysis(ls_preprocessed,
GeneBased=FALSE,
pDataBased=FALSE,
NewCondition=TRUE,
NewCondition_df = p_all_cl_123,
cond_nm='hclust_com',
two_levels=c('4','123'),
reference = '4',
correct_gender=TRUE)## Unlist done## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender hclust_com hclust_ave hclust_mq hclust_w
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 123 1 1 1
## 2 R3388_YZ_2 11646 1 Male 123 1 1 1
## 3 R3388_YZ_3 11820 1 Male 123 1 1 1
## 4 R3388_YZ_4 11652 1 Male 123 1 1 1
## 5 R3388_YZ_5 11855 1 Male 123 1 1 1
## 6 R3388_YZ_6 12890 1 Male 123 1 2 2
## 7 R3388_YZ_7 12994 1 Male 123 1 1 1
## 8 R3388_YZ_9 13155 1 Male 123 1 1 1
## 9 R3388_YZ_… 13014 1 Female 123 1 1 1
## 10 R3388_YZ_… 11561 1 Male 123 1 1 1
## # … with 68 more rows, and 1 more variable: k_means <chr>
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 123 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 123 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 123 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 123 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 123 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 123 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 123 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 123 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 123 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 123 1 1 1 1
## # … with 68 more rows
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 123 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 123 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 123 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 123 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 123 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 123 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 123 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 123 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 123 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 123 1 1 1 1
## # … with 68 more rows
## # A tibble: 78 x 9
## Vantage_ID pt_ID Batch Gender Condition hclust_ave hclust_mq hclust_w k_means
## <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr> <chr>
## 1 R3388_YZ_1 11601 1 Male 123 1 1 1 1
## 2 R3388_YZ_2 11646 1 Male 123 1 1 1 4
## 3 R3388_YZ_3 11820 1 Male 123 1 1 1 1
## 4 R3388_YZ_4 11652 1 Male 123 1 1 1 3
## 5 R3388_YZ_5 11855 1 Male 123 1 1 1 4
## 6 R3388_YZ_6 12890 1 Male 123 1 2 2 3
## 7 R3388_YZ_7 12994 1 Male 123 1 1 1 1
## 8 R3388_YZ_9 13155 1 Male 123 1 1 1 4
## 9 R3388_YZ_… 13014 1 Female 123 1 1 1 4
## 10 R3388_YZ_… 11561 1 Male 123 1 1 1 1
## # … with 68 more rows## Labeling done## Filtering done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Design done## Warning in DESeqDataSet(se, design = design, ignoreRank): some variables in
## design formula are characters, converting to factors## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## Warning: Setting row names on a tibble is deprecated.## vsd symbols done## using pre-existing size factors## estimating dispersions## gene-wise dispersion estimates## mean-dispersion relationship## final dispersion estimates## fitting model and testing## -- replacing outliers and refitting for 1447 genes
## -- DESeq argument 'minReplicatesForReplace' = 7
## -- original counts are preserved in counts(dds)## estimating dispersions## fitting model and testing## DESeq done## using 'normal' for LFC shrinkage, the Normal prior from Love et al (2014).
##
## Note that type='apeglm' and type='ashr' have shown to have less bias than type='normal'.
## See ?lfcShrink for more details on shrinkage type, and the DESeq2 vignette.
## Reference: https://doi.org/10.1093/bioinformatics/bty895## Warning: Column `gene`/`ENSEMBL` joining character vector and factor, coercing
## into character vector## res symbols done## list doneDE results
heatmap_200(DE_res_1v2$res_df, DE_res_1v2$vsd_mat_sym, DE_res_1v2$meta_data, DE_res_1v2$pData_rnaseq)
volcano_plot(DE_res_1v2$res_df, gene=NULL, p_title='Clusters: 1 vs 2')
heatmap_200(DE_res_3v1$res_df, DE_res_3v1$vsd_mat_sym, DE_res_3v1$meta_data, DE_res_3v1$pData_rnaseq)
volcano_plot(DE_res_3v1$res_df, gene=NULL, p_title='Clusters: 3 vs 1')
heatmap_200(DE_res_3v2$res_df, DE_res_3v2$vsd_mat_sym, DE_res_3v2$meta_data, DE_res_3v2$pData_rnaseq)
volcano_plot(DE_res_3v2$res_df, gene=NULL, p_title='Clusters: 3 vs 2')
heatmap_200(DE_res_3v12$res_df, DE_res_3v12$vsd_mat_sym, DE_res_3v12$meta_data, DE_res_3v12$pData_rnaseq)
volcano_plot(DE_res_3v12$res_df, gene=NULL, p_title='Clusters: 3 vs 1+2')
heatmap_200(DE_res_4v123$res_df, DE_res_4v123$vsd_mat_sym, DE_res_4v123$meta_data, DE_res_4v123$pData_rnaseq)
volcano_plot(DE_res_4v123$res_df, gene=NULL, p_title='Clusters: 4 vs 1+2+3')
Pathway enrichment analysis fGSEA
fgsea_res_1v2 <- fgsea_analysis(DE_res_1v2)## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.fgsea_res_3v1 <- fgsea_analysis(DE_res_3v1)## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.07% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.fgsea_res_3v2 <- fgsea_analysis(DE_res_3v2)## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.03% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.fgsea_res_3v12 <- fgsea_analysis(DE_res_3v12)## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.fgsea_res_4v123 <- fgsea_analysis(DE_res_4v123)## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.
## Warning in fgsea(pathways = gmtPathways(pthw_path), stats = ranks, nperm = 1000): There are ties in the preranked stats (0.01% of the list).
## The order of those tied genes will be arbitrary, which may produce unexpected results.Clusters: 1 vs 2
fgsea_res <- fgsea_res_1v2
cond_nm <- 'Clusters: 1 vs 2'
fgsea_plot(fgsea_res$res_hm, pathways_title='Hallmark', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------------------------------------- ---------- ---------- ----------- ---------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## HALLMARK_MYC_TARGETS_V2 0.0020450 0.0068166 -0.6927090 -2.762584 0 57 TBRG4 EXOSC5 FARSA MYBBP1A PPAN NOC4L IMP4 PUS1 SRM RRP12 CBX3 MPHOSPH10 NOP2 CDK4 RRP9 AIMP2 HSPD1 PES1 GRWD1 MCM4 NOP56 PLK1 PPRC1 BYSL GNL3 IPO4 SLC29A2 LAS1L PA2G4 MRTO4 NOLC1 PHB RABEPK WDR74 MCM5 SORD down
## HALLMARK_MYC_TARGETS_V1 0.0019960 0.0068166 -0.5462614 -2.706514 0 189 EIF3B HDGF PPM1G CYC1 CAD RANBP1 CCT3 CSTF2 PSMD3 CCT7 NHP2 LSM7 CCT5 ODC1 SRM CBX3 MCM7 HSP90AB1 TUFM CDK4 RRP9 AIMP2 HSPD1 MRPL9 MCM2 PABPC1 CCT2 POLD2 SNRPA NME1 PSMC4 APEX1 RNPS1 TRIM28 SRPK1 MCM4 NOP56 RPS10 ILF2 CDC20 HNRNPA1 FBL SMARCC1 GNL3 IMPDH2 TXNL4A PA2G4 PPIA PSMB3 PRDX4 NOLC1 KPNB1 RPS2 C1QBP HNRNPU PSMA6 PHB RUVBL2 MRPL23 NDUFAB1 PSMA7 SF3B3 TFDP1 NCBP2 RAD23B PSMD8 RPS6 MCM5 CCNA2 XPOT SF3A1 GOT2 RFC4 CCT4 PRPF31 RSL1D1 MAD2L1 CANX RPL14 CTPS1 COPS5 PSMB2 HNRNPA2B1 XRCC6 SNRPD2 SET MCM6 SNRPD1 RPS3 PSMD14 CDC45 PABPC4 RPL18 PTGES3 GLO1 PRPS2 EIF3D EIF2S2 down
## HALLMARK_E2F_TARGETS 0.0020040 0.0068166 -0.5254627 -2.600708 0 191 TK1 TBRG4 CIT MYBL2 TIMELESS RANBP1 WDR90 POLD1 UBE2T PNN SSRP1 AK2 TUBG1 RNASEH2A MCM7 HMGA1 CDK4 ASF1B NUP107 TACC3 CDC25B TP53 KIF22 AURKB MCM2 DNMT1 CDCA8 BIRC5 POLD2 NME1 ILF3 KIF18B PAICS MCM4 MXD3 NOP56 UBE2S SPC24 LIG1 PTTG1 CDC20 PLK1 POLE MKI67 KIF2C POP7 PA2G4 GINS4 SHMT1 PRDX4 CDC25A RRM2 NOLC1 ESPL1 ATAD2 AURKA DDX39A LMNB1 TOP2A CENPM SMC4 KIF4A PRKDC MELK HMMR SLBP PMS2 SPAG5 NCAPD2 MCM5 CENPE EZH2 HMGB2 DSCC1 CCNE1 GINS1 CDKN3 MCM3 MAD2L1 DLGAP5 CTPS1 HELLS STMN1 CDK1 BUB1B DCTPP1 PLK4 BRCA1 PPP1R8 XRCC6 RACGAP1 PSMC3IP MCM6 CHEK2 down
## HALLMARK_GLYCOLYSIS 0.0020243 0.0068166 -0.4930279 -2.436095 0 188 PC IDUA CHPF2 SDC1 B4GALT7 SLC25A10 HS6ST2 HSPA5 XYLT2 GMPPA TSTA3 RBCK1 AGRN B3GALT6 B3GAT3 HAX1 NOL3 SRD5A3 TALDO1 LHPP POLR3K ANKZF1 CHST12 PGLS ENO1 ALDOA SPAG4 PSMC4 PAXIP1 MED24 GYS1 ABCB6 GUSB GOT1 VEGFA QSOX1 G6PD CASP6 ALG1 GALK1 HDLBP KIF20A PPIA LCT NDUFV3 AURKA FKBP4 EGFR PMM2 B4GALT2 GPC4 PKM PFKP MPI AKR1A1 EFNA3 HMMR CENPA SOD1 PAM MET B3GAT1 SLC37A4 GALE TXN ANGPTL4 CHPF FUT8 CLN6 ME1 PYGB GOT2 GAPDHS GFPT1 DPYSL4 ISG20 SLC16A3 PFKFB1 ADORA2B IRS2 CLDN9 IDH1 STMN1 CDK1 COPB2 PPFIA4 SDHC COG2 TPBG GPR87 GNPDA1 GPC1 NT5E down
## HALLMARK_G2M_CHECKPOINT 0.0020325 0.0068166 -0.4861889 -2.399430 0 187 DTYMK MYBL2 NCL UBE2C E2F1 EGF ODC1 E2F4 HMGA1 CDK4 TACC3 CDC25B UPF1 CHAF1A KIF22 TRAIP AURKB MCM2 INCENP BIRC5 CCNF ILF3 E2F2 TPX2 UBE2S PTTG1 CDC20 CBX1 PLK1 POLE MKI67 KIF2C SMARCC1 PRMT5 TROAP BUB1 TNPO2 CDC25A CCND1 KIF15 NEK2 NOLC1 ESPL1 KPNB1 AURKA DDX39A HNRNPU EXO1 LMNB1 TOP2A CENPF SMC4 KIF4A POLQ CDC6 TLE3 SLC7A5 TOP1 E2F3 HMMR RAD54L CHMP1A EFNA5 NDC80 CENPA NUMA1 TFDP1 RAD23B MCM5 CENPE EZH2 RBM14 CCNA2 ODF2 PRC1 HSPA8 HIRA KIF11 CDKN3 MCM3 LIG3 MAD2L1 ATF5 BCL3 STMN1 CDK1 TTK PLK4 SLC7A1 NUSAP1 RACGAP1 MCM6 SNRPD1 KIF20B CDC45 ORC6 STIL down
## HALLMARK_DNA_REPAIR 0.0019194 0.0068166 -0.4926396 -2.358872 0 141 TAF6 SUPT5H SNAPC4 ALYREF ITPA POLL DGCR8 ERCC2 POLR2D CANT1 NME4 POLR2H APRT NELFCD NELFB ERCC3 POLD1 SSRP1 GPX4 POLR2J TARBP2 NT5C TP53 FEN1 SAC3D1 VPS28 UMPS NME1 GTF3C5 NME3 ADRM1 EDF1 POLD4 LIG1 POLR1C GUK1 POLR2E MPG POLR2A IMPDH2 RAE1 ZWINT GTF2F1 SEC61A1 POLR2I UPF3B AAAS POLH POLR2F NCBP2 TAF1C BCAM down
## HALLMARK_UNFOLDED_PROTEIN_RESPONSE 0.0019231 0.0068166 -0.4977919 -2.257474 0 103 HSPA5 EIF4G1 EXOSC5 NOP14 NHP2 LSM4 EDC4 CXXC1 ARFGAP1 RRP9 PDIA6 PREB PSAT1 CALR EXOSC2 ALDH18A1 NOP56 BANF1 VEGFA KHSRP BAG3 HSP90B1 EIF4A3 NOLC1 NFYA YIF1A SLC7A5 SRPRB DCTN1 HSPA9 FUS FKBP14 PARN TATDN2 XPOT ZBTB17 ERN1 PAIP1 SLC1A4 EXOSC1 GEMIN4 SHC1 GOSR2 ASNS EEF2 PDIA5 XBP1 down
## HALLMARK_UV_RESPONSE_DN 0.0020325 0.0068166 0.4559836 2.175123 0 136 CAV1 PTGFR TGFBR3 PLCB4 PPARG PMP22 AKT3 ACVR2A TGFBR2 DAB2 NEK7 EFEMP1 FBLN5 GRK5 INSIG1 PTEN PTPN21 BMPR1A MAGI2 APBB2 SDC2 MAP2K5 SCAF8 ANXA4 PIK3R3 KALRN PDLIM5 NFIB PTPRM SCHIP1 TJP1 ATP2B1 ADD3 NR1D2 ATP2C1 LTBP1 CDON RND3 MT1E SNAI2 INPP4B BDNF DYRK1A GJA1 VLDLR LDLR TFPI PDGFRB SMAD7 MMP16 MRPS31 ANXA2 YTHDC1 ATXN1 RASA2 RBPMS DLC1 ZMIZ1 PRKCE NFKB1 SPOP CELF2 DUSP1 SMAD3 CAP2 COL5A2 COL1A2 SERPINE1 SIPA1L1 DLG1 up
## HALLMARK_MTORC1_SIGNALING 0.0019960 0.0068166 -0.4226994 -2.093823 0 190 HMBS ABCF2 HSPA5 SDF2L1 PDAP1 FKBP2 TUBA4A STIP1 SQSTM1 SHMT2 TUBG1 TRIB3 YKT6 TM7SF2 NMT1 RRP9 PSAT1 HSPD1 CALR MCM2 TOMM40 CCT6A ENO1 CCNF ALDOA NFKBIB PSMC4 PFKL MCM4 FDXR GOT1 PLK1 G6PD ARPC5L HSP90B1 BUB1 PSMB5 PSMD13 MLLT11 PPIA PSME3 CDC25A RRM2 AURKA DDX39A DHCR7 CACYBP GPI SLC7A5 ACACA PSPH SRD5A1 GAPDH DHFR HSPA9 CORO1A SLC37A4 RPN1 SORD ME1 SLC1A5 SERPINH1 SLC1A4 CANX ASNS IDH1 COPS5 GSR DDIT3 TXNRD1 HSPA4 ACLY XBP1 down
## HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 0.0019960 0.0068166 0.4194355 2.082911 0 189 TGFBR3 SLIT2 FGF2 SGCG ABI3BP SGCB ECM2 ID2 PMP22 DAB2 SLIT3 DCN FBLN5 CDH6 FBLN1 FERMT2 SGCD MYLK TIMP3 NTM PCOLCE2 DST PTX3 SFRP1 VIM MYL9 ACTA2 BMP1 CD44 LOX CXCL12 TAGLN LAMA2 EDIL3 LUM ITGA5 TPM1 MATN3 CALD1 MMP1 GAS1 CD59 EFEMP2 FAS FOXC2 IL6 VEGFC FSTL1 SPARC MATN2 MMP2 SFRP4 FMOD JUN SNAI2 TPM4 INHBA CDH11 MGP COL12A1 BDNF PRRX1 OXTR HTRA1 GJA1 THBS1 CXCL6 PDGFRB ITGB1 MFAP5 FBLN2 FBN1 COL7A1 IGFBP4 MSX1 NID2 COL16A1 GLIPR1 TNFRSF11B IL15 WNT5A TGM2 EMP3 COL4A2 COL4A1 LRP1 GADD45B COL6A2 CAP2 POSTN FN1 COL5A2 COL1A2 SERPINE1 up
## HALLMARK_OXIDATIVE_PHOSPHORYLATION 0.0019493 0.0068166 -0.3831435 -1.884160 0 175 NDUFS8 NDUFS6 CYC1 RHOT2 PMPCA TIMM50 NDUFV1 GPX4 ECHS1 NDUFS2 LDHB ETFB ACADVL ECI1 MRPS15 NQO2 ATP1B1 MRPS12 COX6C MRPL11 IDH2 TCIRG1 BAX AIFM1 TIMM13 NDUFB7 SDHA ECH1 CS ACAA1 NDUFAB1 NDUFB2 GPI NDUFA1 MRPL15 COX6B1 BCKDHA POLR2F HSPA9 OAT NDUFS3 NDUFA7 GOT2 COX4I1 UQCRFS1 MFN2 NDUFS7 UQCRC1 IDH1 COX17 ACO2 COX7C TIMM8B UQCRQ SDHC TIMM10 HTRA2 TIMM17A SLC25A11 UQCR11 COX5B UQCRH OGDH TOMM22 down
## HALLMARK_PI3K_AKT_MTOR_SIGNALING 0.0019231 0.0068166 -0.3840047 -1.741452 0 103 TRAF2 RPTOR E2F1 SQSTM1 TRIB3 PITX2 CDK4 PPP1CA HRAS CALR AKT1S1 NFKBIB THEM4 ARHGDIA TSC2 HSP90B1 STAT2 SFN ARF1 AKT1 PAK4 EGFR TNFRSF1A ACACA CFL1 GNGT1 PIN1 ITPR2 MKNK2 FGF22 RIPK1 NOD1 PLCG1 ECSIT CDK1 DDIT3 LCK PFN1 CLTC MAPK9 RIT1 down
## HALLMARK_MYOGENESIS 0.0019960 0.0068166 0.3315782 1.647741 0 190 FHL1 MEF2A FGF2 SGCG SORBS1 CD36 DMD REEP1 CASQ2 ACTN2 RB1 MYH2 LDB3 ACTC1 CDH13 PKIA MYH1 SGCD CFD SSPN DES MYLK PRNP NOS1 MYBPC3 SORBS3 PPP1R3C MYH11 MYOZ1 MYH8 MYOM1 CNN3 GABARAPL2 FKBP1B TAGLN GPX3 LAMA2 SGCA MYL3 PTGIS WWTR1 CSRP3 IGFBP7 SCHIP1 IGF1 DTNA MEF2C CAMK2B FXYD1 MYL1 SPARC HSPB8 MYH4 EIF4A2 GJA5 up
## HALLMARK_KRAS_SIGNALING_UP 0.0019960 0.0068166 0.3310422 1.645078 0 190 CAB39L MTMR10 USH1C EVI5 IL33 ANXA10 PRKG2 TMEM100 ID2 PECAM1 USP12 KLF4 SPARCL1 SPON1 CA2 CDADC1 PEG3 PTPRR BTBD3 ABCB1 GPRC5B RBP4 WNT7A GYPC EMP1 PTBP2 EPB41L3 RELN GNG11 NR0B2 ADAM17 CFH STRN TPH1 TRIB2 CBR4 TSPAN1 ETV1 VWA5A IGF2 INHBA ENG CMKLR1 PRRX1 ACE ARG1 CBL FGF9 IL1B ETS1 TFPI PDCD1LG2 GPNMB HOXD11 ALDH1A2 CTSS ITGBL1 PPBP GALNT3 CCND2 C3AR1 PPP1R15A MMP11 SNAP25 RETN CROT SATB1 HBEGF GFPT2 HSD11B1 TLR8 SPRY2 MAP3K1 LCP1 LY96 CCSER2 F13A1 HDAC9 TMEM158 SERPINA3 LAPTM5 RABGAP1L up
## HALLMARK_UV_RESPONSE_UP 0.0019417 0.0068166 -0.3378592 -1.625328 0 147 STK25 PDAP1 TUBA4A STIP1 POLR2H ONECUT1 MARK2 SQSTM1 EPCAM SPR YKT6 CHRNA5 FEN1 MAPK8IP2 E2F5 SIGMAR1 CLCN2 ALDOA WIZ PSMC3 CDC34 AQP3 HNRNPU ACAA1 FKBP4 MRPL23 PPIF EPHX1 CYB5R1 PPAT AGO2 FURIN STARD3 BAK1 BSG RPN1 CCNE1 RFC4 LYN ASNS RHOB ICAM1 TGFBRAP1 MAOA PARP2 NKX2-5 KLHDC3 BTG3 down
## HALLMARK_COAGULATION 0.0039761 0.0110889 0.3339103 1.568837 1 127 SERPINB2 PROS1 HNF4A PECAM1 GDA P2RY1 GNG12 A2M CFD OLR1 TIMP3 F10 PLG VWF CPQ ADAM9 BMP1 SERPING1 HMGCS2 C8B MMP1 PRSS23 CSRP1 CFH F11 LEFTY2 MAFF PDGFB SPARC PF4 MMP2 C9 CPB2 MASP2 GSN HTRA1 KLKB1 THBS1 PREP F2 THBD CTSK ANXA1 FBN1 RAPGEF3 F2RL2 ANG up
## HALLMARK_MITOTIC_SPINDLE 0.0039216 0.0110889 -0.3003997 -1.497194 1 195 PCNT CSNK1D CEP250 BIN1 CEP72 RHOT2 ATG4B TUBA4A KIF22 INCENP SAC3D1 MARK4 BIRC5 DYNLL2 MAP1S TPX2 TBCD ARHGAP27 LLGL1 ARHGDIA PLK1 ARL8A CYTH2 MAP3K11 KIF2C CTTN BUB1 TUBGCP6 KIF15 NEK2 ESPL1 AURKA ARHGEF11 PLEKHG2 LMNB1 TOP2A ANLN SHROOM1 CENPF SMC4 KIF4A CNTROB KPTN NDC80 TUBGCP2 CENPJ BCR NUMA1 ARFIP2 CDK5RAP2 RHOF CENPE KATNB1 ARF6 PRC1 TRIO KIF11 GEMIN4 DLGAP5 TAOK2 EPB41 KNTC1 CLASP1 CDK1 DYNC1H1 TTK TUBD1 NET1 NUSAP1 PIF1 RACGAP1 down
## HALLMARK_ESTROGEN_RESPONSE_LATE 0.0039920 0.0110889 -0.2959030 -1.466501 1 193 MDK MAPK13 PCP4 TSTA3 SCNN1A TFPI2 PKP3 TFAP2C LSR DCXR NAB2 ST14 RNASEH2A AREG UGDH DLG5 ETFB NMU BATF COX6C LLGL2 CDC20 IDH2 SFN NCOR2 KIF20A CCND1 FKBP4 TOP2A DHCR7 CDH1 PPIF CDC6 SLC7A5 CISH ANXA9 BLVRB ALDH3A2 SLC2A8 RPS6KA2 ACOX2 CXCL14 SIAH2 OPN3 PLXNB1 KCNK5 GALE SORD TJP3 KRT13 FRK DNAJC12 NXT1 ISG20 S100A9 CELSR2 SLC1A4 GPER1 UNC13B IMPA2 down
## HALLMARK_TGF_BETA_SIGNALING 0.0058939 0.0155103 0.4156129 1.673315 2 54 BMPR2 ID2 SPTBN1 BMPR1A UBE2D3 KLF10 SMAD6 TRIM33 WWTR1 TJP1 PPM1A APC LEFTY2 SMAD1 ENG MAP3K7 THBS1 TGFBR1 BCAR3 SMAD7 LTBP2 FKBP1A ID3 PPP1R15A CDKN1C SMAD3 JUNB SKIL SERPINE1 up
## HALLMARK_FATTY_ACID_METABOLISM 0.0077670 0.0194175 -0.2909658 -1.399739 3 147 CBR1 GCDH REEP6 D2HGDH ENO3 ODC1 PCBD1 ECHS1 CBR3 UGDH FASN BLVRA ACADVL ACOT8 ECI1 ALDOA APEX1 GRHPR BPHL ALDH3A1 NTHL1 SDHA ECH1 AQP7 CPOX ALAD ACAA1 EPHX1 CRAT NCAPH2 ERP29 GSTZ1 UROS ALDH3A2 PRDX6 ACSL5 CEL ME1 GAPDHS CCDC58 IL4I1 IDH1 SLC22A5 EHHADH ACO2 SDHC PSME1 down
## HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 0.0098232 0.0233885 -0.4289486 -1.645942 4 46 STK25 MGST1 ERCC2 GPX4 NDUFS2 PRDX2 NQO1 G6PD SRXN1 ATOX1 PRDX4 TXNRD2 PFKP SBNO2 PRDX6 SOD1 TXN GSR ABCC1 EGLN2 TXNRD1 down
## HALLMARK_P53_PATHWAY 0.0119760 0.0261392 -0.2808287 -1.391073 5 190 SDC1 PVT1 RAB40C TRAF4 HDAC3 DCXR TRIB3 ST14 LDHB CSRNP2 TP53 HRAS GLS2 FDXR EPS8L2 RHBDF2 BAX OSGIN1 RAD9A SFN WRAP73 TNFSF9 MDM2 VDR PMM1 STEAP3 VAMP8 EPHX1 IER5 RPL36 DEF6 ALOX15B SEC61A1 AEN MAPKAPK3 CYFIP2 POLH RNF19B ABHD4 IP6K2 BAK1 SLC3A2 MKNK2 RALGDS BAIAP2 PHLDA3 NOL8 PRMT2 SERTAD3 DDIT3 INHBB TRAFD1 PRKAB1 ACVR1B AK1 PLXNB2 TNNI1 CDKN2A GADD45A RXRA RPL18 PTPRE UPP1 LIF HEXIM1 CCND3 CDK5R1 GPX2 down
## HALLMARK_ESTROGEN_RESPONSE_EARLY 0.0120240 0.0261392 -0.2759695 -1.365874 5 191 ISG20L2 GREB1 SYT12 SCNN1A MYBBP1A CANT1 TFAP2C RRP12 NADSYN1 AREG FASN CLDN7 TBC1D30 UNC119 KRT18 MED24 AQP3 LAD1 SFN TGIF2 NCOR2 MUC1 ESRP2 MREG RHOD RAB17 CCND1 FKBP4 DHCR7 KRT8 PPIF AKAP1 SLC7A5 MLPH CISH SYBU ANXA9 BLVRB RPS6KA2 TSKU PMAIP1 SIAH2 RHOBTB3 KDM4B OPN3 DEPTOR KCNK5 CELSR1 TJP3 KRT13 FRK P2RY2 NXT1 CELSR2 down
## HALLMARK_INTERFERON_ALPHA_RESPONSE 0.0196078 0.0408497 -0.3304660 -1.461710 9 93 ADAR RNF31 IRF7 HELZ2 PSME2 LGALS3BP CMTR1 LY6E OGFR ISG15 STAT2 MVB12A IFI35 PARP14 MOV10 TRIM14 BATF2 NUB1 PARP9 ISG20 UBA7 OAS1 MX1 IRF9 SP110 PSME1 TRAFD1 CD74 USP18 CXCL10 down
## HALLMARK_INTERFERON_GAMMA_RESPONSE 0.0217822 0.0435644 -0.2670132 -1.327776 10 194 ADAR RNF31 IRF7 HELZ2 RBCK1 RNF213 PSME2 LGALS3BP METTL7B ST3GAL5 CMTR1 MX2 MVP LY6E OGFR ISG15 STAT2 VAMP5 IFI35 VAMP8 OAS3 PARP14 PLA2G4A PFKP AUTS2 TRIM14 IL2RB STAT1 IL18BP NUP93 BATF2 ZBP1 CD38 ISG20 CXCL9 RIPK1 NOD1 SECTM1 IRF4 NLRC5 ICAM1 PSMB2 MX1 PSMB10 IRF9 SP110 PSME1 ITGB7 TRAFD1 down
## HALLMARK_ANDROGEN_RESPONSE 0.0244898 0.0470958 0.3098869 1.389142 11 96 PIAS1 HERC3 SLC38A2 INSIG1 HMGCS1 PTPN21 SLC26A2 CDK6 APPBP2 LIFR ADAMTS1 SGK1 IQGAP2 PDLIM5 MAK IDI1 GNAI3 HMGCR BMPR1B INPP4B KLK2 NKX3-1 PGM3 CDC14B ACTN1 SPCS3 MAF up
fgsea_plot(fgsea_res$res_c1, pathways_title='C1 positional genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------- ---------- ---------- ----------- ---------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## chr17q25 0.0020243 0.0063113 -0.6426942 -3.221267 0 202 DUS1L ANAPC11 CBX4 CCDC137 NPLOC4 SLC38A10 TMC6 UBE2O TK1 P4HB PYCR1 NAT9 FOXK2 CHMP6 GPS1 RPTOR CBX8 LRRC45 OGFOD3 CCDC57 MRPL12 RFNG SLC25A10 EVPL CSNK1D SYNGR2 ALYREF HGS TBC1D16 GGA3 SIRT7 ENDOV PPP1R27 ASPSCR1 TSEN54 RNF213 CANT1 RAC3 RECQL5 OXLD1 MRPL38 LGALS3BP NARF B3GNTL1 DCXR CARD14 FN3KRP EXOC7 COG1 ZNF750 RPL38 NT5C FSCN2 ARL16 FASN SRP68 MRPS7 WDR45B TMEM104 GPRC5C NPTX1 BIRC5 TSPAN10 FN3K SGSH AFMID ENGASE SAP30BP TBCD TRIM65 FDXR FBF1 LLGL2 PCYT2 ARHGDIA RHBDF2 UNK FADS6 HID1 GALK1 MIR4730 RBFOX3 CD7 TNRC6C-AS1 NARF-IT1 EIF4A3 KCTD2 GAA CDK3 PGS1 LINC00482 USH1G NUP85 ARMC7 RAB40B RPL9P29 SNORD1B RPL31P7 SLC39A11 UBALD2 MYADML2 MIR4525 SNHG16 TEN1-CDK3 SLC26A11 BAHCC1 TRIM47 UTS2R MIR4316 MAFG TMC8 WBP2 ZACN BAIAP2 MIF4GD RNF157-AS1 SLC16A3 MIR1250 SECTM1 GALR2 AANAT down
## chr19p13 0.0019157 0.0063113 -0.5591237 -3.102739 0 544 NACC1 ANO8 MRPL4 NCLN GTPBP3 NR2F6 HOOK2 MAST1 TRMT1 TMEM59L LONP1 CRLF1 QTRT1 AP3D1 RFXANK SMARCA4 KRI1 STAP2 NR2C2AP GCDH CAMSAP3 ATP13A1 RGL3 REEP6 FARSA TCF3 PPAN KISS1R THOP1 CC2D1A WDR18 SLC39A3 TYK2 JSRP1 CRTC1 STX10 LSM7 LSM4 YIPF2 GPX4 LMNB2 TMEM161A IL27RA RAVER1 ATG4D DENND1C TLE6 ABCA7 STXBP2 UHRF1 ZNF414 STK11 CRB3 RNASEH2A POLRMT DIRAS1 TUBB4A AP1M2 CSNK1G2-AS1 ARID3A SIRT6 ASF1B GADD45GIP1 RNF126 RPS18P13 RAB3D PRKCSH UPF1 CHAF1A C19orf57 MAP2K2 DPP9 CCDC124 P2RY11 DOHH SH2D3A TMPRSS9 C19orf25 TIMM44 NDUFA13 CALR CCL25 SUGP1 CACTIN DNMT1 KEAP1 CHERP PGLS APC2 VMAC BABAM1 DAZAP1 ARMC6 NDUFA11 HSH2D ELOF1 MPND GIPC1 HNRNPA1P10 AMH WIZ SLC25A23 HSD11B1L ILF3 MAP1S SCAMP4 BTBD2 PRDX2 LRRC8E PLEKHJ1 ADAT3 COPE SYCE2 PIAS4 EVI5L PCSK4 MEX3D FBXW9 EPHX3 RAD23A SPPL2B SPC24 CDC34 R3HDM4 ZNF653 SNORD105B GMIP APBA3 TMEM259 MED16 ZSWIM4 THEG HMG20B EPOR CCDC130 RN7SL619P AKAP8L GAMT SLC35E1 KHSRP HCN2 DDA1 CSNK1G2 CARM1 KCNN1 PCP2 POLR2E C19orf53 WDR83 DUS3L SF3A2 PTBP1 FEM1A LPAR2 XAB2 SAMD1 CCDC159 TIMM13 PET100 SGTA IL12RB1 NDUFB7 TNPO2 RAB11B MBD3 TNFSF9 EIF3G RN7SL477P MAP2K7 REXO1 RFX1 KLHL26 DCAF15 MVB12A KLF16 TMED1 PRR22 RN7SL192P ILVBL ZNF554 SIN3B PLK5 DDX39A CD320 GATAD2A RN7SL146P CELF5 MAU2 FCHO1 TPGS1 FSD1 ZGLP1 GTF2F1 JAK3 RAB3A RPL36 IZUMO4 DDX49 MIDN HMGB2P1 RNU6-1223P KXD1 DHPS BRD4 MLLT1 YJEFN3 ICAM3 SBNO2 PIN1 TSPAN16 MIER2 HNRNPM ZNF77 CDC37 OLFM2 PKN1 TLE2 USE1 GDF15 TECR ANKLE1 NANOS3 MPV17L2 KDM4B ABHD17A FUT3 RANBP3 MEF2B MOB3A CERS4 C3P1 BSG ANGPTL4 UBXN6 MKNK2 ZNF627 SSBP4 PGLYRP2 SLC25A42 TJP3 MRI1 ANGPTL6 INSL3 FGF22 CIRBP-AS1 NDUFA7 SAFB PLIN5 TGFBR3L EPS15L1 MAST3 TMEM205 MFSD12 SH3GL1 RASAL3 SUGP2 FKBP8 ZNF101 CLPP PDE4A PLIN4 SWSAP1 RNU6-9 RPS15 RLN3 NDUFS7 PGPEP1 CD70 LRG1 PLIN3 ECSIT FZR1 GPR108 ICAM1 ICAM5 down
## chr1p31 0.0019194 0.0063113 0.6301277 2.933309 0 120 GIPC2 PTGFR TCTEX1D1 RAVER2 ST6GALNAC3 ROR1 WDR78 MIR3671 NEGR1 LEPROT DNASE2B DNAJB4 NEXN TTLL7 ST13P20 GNG12 LEPR CFL1P3 RNU6-1102P USP33 SLC2A3P2 LRRC7 NFIA FPGT MIER1 DOCK7 ST6GALNAC5 MIR3117 RNA5SP23 ANGPTL3 MIR101-1 TM2D1 RNU6-1176P PIGK SGIP1 GDI2P2 AK5 ATG4C KANK4 MIR186 MIR4794 C1orf141 TTLL7-IT1 ZRANB2-AS2 RNU6-809P EFCAB7 RNA5SP22 LRRIQ3 RNU4-88P RNFT1P2 ZRANB2 LRRC40 CACHD1 FUBP1 HNRNPA3P14 ACADM JAK1 PRKACB NEXN-AS1 RNA5SP20 TYW3 ZRANB2-AS1 RN7SL370P SLC35D1 PDE4B SRSF11 LRRC53 DIRAS3 FPGT-TNNI3K PSAT1P3 TNNI3K USP1 RN7SL130P L1TD1 ARL5AP3 up
## chr9q34 0.0020964 0.0063113 -0.5715628 -2.872634 0 210 MIR4479 TRAF2 RABL6 PIP5KL1 SNAPC4 DPH7 ZMYND19 TRUB2 RNF208 WDR5 ASB6 PMPCA DBH-AS1 NDOR1 QSOX2 MAN1B1 SAPCD2 FBXW5 NOXA1 ZDHHC12 NELFB SEC16A SARDH WDR34 DOLPP1 GOLGA2 FPGS NTMT1 SNHG7 PTGES2 MAMDC4 PHPT1 SLC27A4 EHMT1 GRIN1 DPM2 PPP1R26 PRRC2B MRPS2 ANAPC2 EXOSC2 C8G ST6GALNAC4 SSNA1 ARRDC1 GTF3C5 NSMF SWI5 MRPL41 EDF1 DPP7 USP20 DBH C9orf50 NCLP1 TBC1D13 PPP1R26-AS1 CIZ1 LCN12 ABCA2 SH3GLB2 TMSB4XP4 KCNT1 NAIF1 C9orf163 DDX31 TOR2A POMT1 AGPAT2 C9orf16 GLE1 TOR4A TPRN CRAT PAEP LCN8 ENDOG BRD3 FCN2 TMEM203 ZER1 SLC34A3 INPP5E FUT7 TMEM141 ENTPD8 CEL VTI1BP4 UCK1 NUP188 COQ4 MIR4292 RALGDS ODF2 EXD3 CDK9 RNF224 HMGA1P4 TTF1 down
## chr16p13 0.0020619 0.0063113 -0.5491170 -2.858774 0 272 RHBDL1 RPUSD1 TELO2 MRPS34 CHTF18 NMRAL1 NUBP2 TBL3 SNRNP25 CAPN15 MRPL28 MSRB1 AXIN1 NUDT16L1 TFAP4 RHOT2 DNAJA3 SLX4 KCTD5 NME4 ZNF598 TRAP1 RAB40C TSR3 FBXL16 DECR2 WASH4P WDR90 E4F1 NPRL3 ZNF213 MLST8 PKMYT1 RMI2 CLCN7 SRRM2-AS1 ROGDI ANKS3 THOC6 SMIM22 EME2 POLR3K MSLNL GLYR1 UBE2I STUB1 SNORD60 ZNF205 ZNF500 PIGQ UNKL GFER ECI1 MGRN1 WDR24 C16orf91 CCNF TRAF7 UBALD1 GNPTG RNPS1 NME3 DNASE1 WFIKKN1 CASKIN1 JMJD8 TSC2 DNASE1L2 UBN1 HAGH NTHL1 ALG1 MPG NTN3 METRN PAM16 AMDHD2 LMF1 CLDN6 MIR5587 PRSS27 MIR3176 TPSP2 ABCC6 RPS2 WASIR2 SPSB3 PPL MSLN CCDC154 PMM2 NOMO1 SRRM2 NDUFB10 GNG13 MAPK8IP3 TNFRSF12A PGP SNHG9 SYNGR3 HAGHL NUBP1 TMEM186 NAGPA KREMEN2 RN7SL850P MIR3177 HCFC1R1 BRICD5 NDE1 ZNF174 METTL22 RHBDF1 TEKT5 DDX11L10 TXNDC11 PARN IL9RP3 MMP25 RAB11FIP3 RNF151 ZSCAN32 ABCC6P2 ZNF263 FAHD1 C16orf96 FLYWCH1 RSL1D1 LINC00514 RPS26P52 FLYWCH2 down
## chr1q22 0.0020576 0.0063113 -0.7031746 -2.847019 0 53 UBQLN4 SLC50A1 C1orf61 SMG5 RHBG DAP3 LAMTOR2 GON4L RAB25 CCT3 TSACC MTX1 MEX3A TMEM79 IQGAP3 TRIM46 SCARNA4 POU5F1P4 KRTCAP2 MSTO2P PMF1 ASH1L-AS1 MEF2D MUC1 THBS3 FDPS SSR2 MSTO1 YY1AP1 GBA RUSC1 TTC24 DPM3 PAQR6 BGLAP MTX1P1 RNU6-106P ASH1L MIR92B EFNA1 ASH1L-IT1 RIT1 down
## chr11q13 0.0020202 0.0063113 -0.5413670 -2.842989 0 290 SPTBN2 INPPL1 PC RCE1 DPP3 NDUFS8 TMEM134 PPP1R14B SYT12 CCS CDK2AP2 CORO1B FAM86C1 FLRT1 FADD MEN1 BRMS1 ANKRD13D RPS6KB2 PITPNM1 GUCY2EP MRPL21 SYVN1 NUDT8 NDUFV1 FKBP2 STIP1 SART1 RN7SL12P MARK2 ESRRA SNORD15B SSH3 SCYL1 KLC2 EHBP1L1 ZDHHC24 NADSYN1 FAM86C2P OTUB1 TM7SF2 TRPT1 CARNS1 C11orf80 GPR137 KDM2A FTLP6 SF3B2 PPP1CA KRTAP5-8 CAPN1 CLCF1 SAC3D1 MALAT1 KRTAP5-7 MACROD1 IGHMBP2 MIR3163 CDCA5 KRTAP5-9 ALG1L9P OVOL1 RPS6KA4 SLC25A45 DRAP1 POLD4 CDC42BPG BANF1 MRPL11 MYO7A CLPB TCIRG1 GSTP1 MAP3K11 ATG2A KRTAP5-10 FIBP RAD9A CTTN LTBP3 FAM89B SLC29A2 NAA40 PAAF1 RHOD LRFN4 MUS81 UCP2 CCND1 PACS1 PTPRCAP TBX10 SIPA1 GPR152 TRMT112 NUDT22 KLHL35 DGAT2 YIF1A CCDC88B CCDC87 DHCR7 ALG1L8P CNIH2 STARD10 RNU7-23P C11orf24 CFL1 EIF1AD DOC2GP ZNHIT2 IL18BP VPS51 AIP TSKU RELA RNF121 DPF2 TPCN2 NUMA1 RAB1B PPME1 P2RY6 PLCB3 HNRNPA1P40 BATF2 KRT8P26 ACY3 MRGPRD RBM14 AP5B1 UCP3 CTSW FRMD8 C11orf72 P2RY2 UNC93B1 TBC1D10C RNASEH2C KAT5 down
## chr7p22 0.0020619 0.0063113 -0.6368172 -2.805890 0 85 PSMG3 EIF3B INTS1 C7orf50 FBXL18 GRID2IP ZNF316 BRAT1 MIR589 AP5Z1 EIF2AK1 PSMG3-AS1 SDK1 MAD1L1 NUDT1 ZNF815P TNRC18 AIMP2 ANKRD61 TTYH3 FOXK1 CHST12 TMEM184A C7orf26 WIPI2 SNX8 PMS2CL FAM220A MAFK COX19 IQCE CARD11 GET4 ZNF890P MICALL2 ZDHHC4 DAGLB PMS2 USP42 TFAMP1 GNA12 MIR339 SLC29A4 OR10AH1P GPER1 RNF216P1 RN7SL851P GPR146 RNU6-218P ALG1L5P ACTB MIR4655 CCZ1 FAM86LP RN7SKP130 PRKAR1B RNF216 ADAP1 down
## chr1q21 0.0020408 0.0063113 -0.5625060 -2.791189 0 191 FLAD1 EFNA4 PYGO2 THEM5 PMVK TDRKH ZBTB7B ZNF687 C2CD4D PSMD4 PBXIP1 ADAR TARS2 UBAP2L UBE2Q1 DCST2 DENND4B HORMAD1 DCST1 HAX1 JTB SCNM1 CRTC2 CGN PI4KB IVL S100A14 ENSA RORC MRPL9 ADAM15 OAZ3 C1orf56 PGLYRP3 SPRR1B S100A2 SPRR2D VPS72 IL6R THEM4 ILF2 RFX5 SETDB1 GATAD2B OR13Z2P CREB3L4 PSMB4 LYSMD1 MLLT11 TUFT1 PGLYRP4 C1orf43 UBE2Q1-AS1 CERS2 S100A1 LINGO4 ANXA9 MRPS21 EFNA3 SLC39A1 LENEP PIP5K1A SPRR2F BCL9 RNU6-1042P CDC42SE1 SPRR2C CHTOP LOR NUP210L RPRD2 MIR5698 RPS27 SPRR2A MIR4257 CA14 S100A9 TPM3 S100A13 SHC1 S100A6 TDRD10 LINC00624 ADAMTSL4-AS1 GOLPH3L MIR4258 RNVU1-7 SNAPIN S100A16 BNIPL PFN1P6 PIAS3 NUDT17 down
## chr8q24 0.0020243 0.0063113 -0.5517136 -2.733523 0 185 RHPN1 ZNF696 EEF1D RECQL4 ZFP41 OPLAH GLI4 TOP1MT TONSL SHARPIN ZNF623 CYHR1 MROH6 KIFC2 ZC3H3 TIGD5 TSNARE1 MFSD3 PVT1 TRAPPC9 C8orf82 MIR1207 PPP1R16A CYC1 TSTA3 MROH1 LRRC14 RHPN1-AS1 GSDMD KCNQ3 COMMD5 PTP4A3 ZNF7 ZNF517 THEM6 TMEM75 TRMT12 SLC45A4 FAM83A EPPK1 C8orf17 VPS28 RPL8 MIR1205 RNU4-25P LY6E GPT MAF1 SLC52A2 ARHGAP39 RNU1-106P SLC39A4 C8orf33 ATAD2 NDUFB9 ADCK5 ZFAT ZNF16 FOXH1 GSDMC MIR151A SNTB1 ZNF251 C8orf31 WDYHV1 PUF60 AGO2 ZNF252P DEPTOR PTK2 MAL2 MAFA FBXL6 SLURP1 DSCC1 UBA52P5 FAM83A-AS1 BOP1 MTBP DUTP2 CPSF1 CDC42P3 EIF3H down
## chr16p11 0.0020790 0.0063113 -0.5770448 -2.667496 0 120 KCTD13 FBRS FBXL19 SRCAP PHKG2 ATXN2L RABEP2 SETD1A RNF40 TBC1D10B ZNF646 ZNF48 CD2BP2 FBXL19-AS1 C16orf58 TUFM KIF22 ZNF785 ATP2A1 SH2B1 PPP4C ZNF764 SLC5A2 ALDOA PRR14 MVP EIF3C MAZ ZNF771 SULT1A3 ZNF768 IGHV3OR16-13 QPRT INO80E HIRIP3 PRSS8 CDC37P1 ZNF629 SEZ6L2 ASPHD1 ARMC5 STX4 ZNF668 SLC7A5P1 ZNF688 KAT8 NFATC2IP FUS CORO1A MIR4519 YPEL3 BCKDK PAGR1 CDIPT TAOK2 BCL7C ZNF689 DCTPP1 VKORC1 CD19 STX1B CLUHP3 TMEM219 PRSS53 HSD3B7 GDPD3 PYDC1 LAT down
## chr22q11 0.0021097 0.0063113 -0.5148660 -2.591944 0 214 YDJC TRMT2A SDF2L1 RANBP1 IGLV3-21 DGCR8 IGLV5-45 ZDHHC8 RGL4 PPIL2 ZNF74 DGCR2 MED15 CHCHD10 DGCR5 SMARCB1 DGCR6L TOP3B IGLV5-37 IGLV8-61 RN7SL280P IGLV1-51 YPEL1 IGLV1-36 KRT18P5 IGLV1-47 BCRP8 GGT1 IGLC7 SLC25A18 GNB1L IGLJ3 IGLV1-50 TXNRD2 LRP5L IGLV9-49 KLHL22 IGLV4-69 ARVCF IGLV3-16 IGLC3 PI4KAP1 IGLV3-22 THAP7 IGLV7-43 CABIN1 TANGO2 IGLV2-14 COMT RN7SL812P IGLV2-23 IGLV2-11 IGLV6-57 IGLV1-44 DDTL DGCR11 IGLV1-62 IGLVIVOR22-1 PEX26 IGLV2-8 BCR LZTR1 IGLV2-5 IGLC6 ASLP1 RN7SL263P MIR185 TMEM191A SLC2A11 IGLJ1 HIRA IGLL5 DGCR9 IGLVI-70 DERL3 IGLV5-52 FBXW4P1 GSTT2 RTN4R BCRP4 RIMBP3 IGLV10-54 LINC00528 LINC00896 ZNF280B IGLV4-60 IGLV3-25 PI4KA ABHD17AP5 ZNF70 GSTT2B IGLV3-12 SERPIND1 AIFM3 IGLV3-4 IGLV3-19 IGLV2-18 USP18 MRPL40 CDC45 CA15P1 VPREB3 CRKL IGLV3-1 GGT3P HIC2 IGLV5-48 BCRP6 GGT5 TBX1 ZDHHC8P1 RN7SL268P MIF CECR7 IGLV3-6 IGLV7-46 IGLV4-3 CLCP1 SPECC1L-ADORA2A IGLV1-41 IGLV11-55 CECR2 GGT2 PRAME POM121L1P PRODH CES5AP1 PI4KAP2 VWFP1 UBE2L3 DNAJA1P6 BCL2L13 CRYBB2 RHEBP3 DDT GGTLC3 TMEM191C down
## chr20q13 0.0020877 0.0063113 -0.4956724 -2.568612 0 265 PABPC1L SAMD10 ZNF512B MTG2 GID8 GMEB2 DDX27 MIR941-2 BCAS4 ZGPAT MYBL2 WFDC10B PRPF6 YTHDF1 SLC2A4RG HELZ2 SLC35C2 MIR647 DNTTIP1 DNAJC5 UBE2C MRGBP PPDPF TFAP2C LSM14B WFDC3 RBBP8NL MYT1 NELFCD WFDC13 RPS4XP3 ABHD16B ZNF335 LIME1 CABLES2 NCOA5 L3MBTL1 ARFGAP1 MIR941-1 HNRNPA1P3 SNX21 ZSWIM1 MIR3617 UCKL1 TAF4 RNU1-134P ACOT8 FITM2 WFDC2 GNAS ADRM1 TOMM34 DIDO1 OGFR TPD52L2 MIR941-3 ARFRP1 EEF1A2 PIGT SPINT4 ZSWIM3 ERP29P1 CYP24A1 TNNC2 ZFP64 C20orf197 OSBPL2 SPINT5P AURKA PTK6 RAE1 ELMO2 OPRL1 TTPAL CTSA ZNF217 NPEPL1 TCFL5 SS18L1 RTEL1 PFDN4 GDAP1L1 PSMA7 PPP1R3D SPINT3 MIR298 COL9A3 RPL12P4 SPATA2 OGFR-AS1 PCIF1 RPS21 ZBP1 SDC4 WFDC8 RBM38 MIR646 ZFAS1 TCEA2 GNAS-AS1 PHACTR3 HAR1A SPATA25 RPS2P7 KCNS1 ADNP PLTP FAM217B RTEL1-TNFRSF6B ATP9A PCMTD2 GTSF1L RPL5P2 TMEM189 SLC9A8 SNORD12B MOCS3 SRSF6 RGS19 CSTF1 STK4-AS1 FAM209B SLC17A9 SGK2 PSMD10P1 WFDC12 GCNT7 ZMYND8 CDH4 RNU6ATAC38P STX16 HAR1B STX16-NPEPL1 MIR3194 RNF114 CEBPB HMGB1P1 MTRNR2L3 MIR4326 PI3 down
## chr7q36 0.0020877 0.0063113 -0.5615385 -2.543844 0 101 SLC4A2 ABCB8 ZNF212 CHPF2 TMUB1 ABCF2 FASTK REPIN1 ZBED6CL ZNF282 ZNF786 PDIA4 ASIC3 CDK5 ATP6V0E2 ZNF746 NOM1 RNY1 XRCC2 PAXIP1 MNX1-AS1 EN2 CRYGN ZNF467 LRRC61 MIR3907 ZNF777 KRBA1 RN7SL521P ZNF862 ZNF783 ZNF398 YBX1P4 NCAPG2 ZNF425 WDR86 ZNF775 PRKAG2-AS1 GALNT11 NOS3 LINC00689 ACTR3B MNX1 MNX1-AS2 ATG9B KMT2C AGAP3 PAXIP1-AS1 EZH2 CCT8L1P NUB1 down
## chr9q21 0.0019342 0.0063113 0.5806813 2.524741 0 86 FRMD3 MAMDC2 ALDH1A1 GNAQ TRPM6 GDA PGM5 TLE4 FAM122A AGTPBP1 DAPK1-IT1 C9orf135 PIP5K1B ANKRD20A3 PRUNE2 KLF9 PCSK5 OSTF1 ANKRD20A1 NTRK2 TMEM252 SNX18P4 RN7SL422P C9orf85 RNU4-29P RNU6-1228P C9orf153 FAM189A2 GAS1 TJP2 ZNF658 ABHD17B PTAR1 RPL24P8 ISCA1 MAMDC2-AS1 CBWD5 TRPM3 RFK C9orf170 CDC20P1 NMRK1 SLC28A3 CEP78 ZFAND5 ANXA1 VPS13A up
## chr3p14 0.0019305 0.0063113 0.5821186 2.523112 0 83 FAM3D PRDX3P4 PRICKLE2 DNASE1L3 PXK ADAMTS9-AS2 DNAH12 FAM107A APPL1 FRMD4B EOGT RBM43P1 DENND6A SNTN PRICKLE2-AS3 ASB14 ADAMTS9-AS1 ABHD6 PRICKLE2-AS2 RNU6-1181P PTPRG-AS1 PTPRG RNF7P1 ADAMTS9 CADPS RPL17P17 ARHGEF3 LMOD3 RNU2-10P PPIAP16 MAGI1-IT1 CACNA2D3-AS1 MAGI1 RNU6-108P TMF1 ILF2P1 MAGI1-AS1 PDHB LRTM1 PSMD6 RPL10AP6 PSMD6-AS2 ESRG IL17RD C3orf49 SLMAP KBTBD8 ARL6IP5 MIR3136 RNU6-787P WNT5A PDE12 UBA3 CCDC66 FLNB-AS1 up
## chr12q21 0.0019305 0.0063113 0.6024164 2.498316 0 66 TRHDE PTPRQ CHCHD3P2 DCN TSPAN19 LIN7A TRHDE-AS1 NAV3 KITLG MGAT4C OSBPL8 METTL25 LRRIQ1 RNU6-977P NTS PPP1R12A ZDHHC17 CAPS2 BBS10 RNA5SP363 LUM TMTC2 ATP2B1 ACSS3 GLIPR1L2 BTG1 CSRP2 PPFIA2 TSPAN8 RASSF9 TMTC3 CEP290 POC1B EPYC MIR618 GLIPR1 NAP1L1 PAWR CENPCP1 PHLDA1 YWHAQP7 MIR1252 up
## chr6q21 0.0019231 0.0063113 0.5934463 2.496433 0 71 REV3L SESN1 TRAF3IP2-AS1 ZNF259P1 REV3L-IT1 RNU6-960P FCF1P5 SOBP ARMC2 TRAF3IP2 LINC00222 CD164 FIG4 BRD7P4 FOXO3 PPIL6 AK9 CDC40 SEC63 SUMO2P8 METTL24 CEP57L1 LAMA4 SLC22A16 SNX3 BVES FCF1P10 DDO SLC16A10 OSTM1 ARMC2-AS1 up
## chr3q13 0.0019194 0.0063113 0.5339883 2.490469 0 121 NR1I2 TUSC7 LSAMP-AS1 LINC00901 CASR LINC00903 LSAMP RNU6-1200P ARHGAP31 RNU1-43P UPK1B RNU6-1127P ARHGAP31-AS1 PHLDB2 RN7SL815P MIR4447 PTMAP8 GRAMD1C RNU5E-8P PHBP8 MIR568 FCF1P3 MAATS1 RN7SL582P RPS26P21 ZBTB20-AS3 MTND4P16 LINC00882 LINC00636 CCDC54 SLC35A5 B4GALT4 FBXO40 YBX1P3 BBX BOC FSTL1 LRRC58 MTND1P16 DZIP3 OR7E100P CD200 CCDC80 ZBTB20-AS1 RNU4-62P ADPRH B4GALT4-AS1 TMPRSS7 TAGLN3 BZW1P2 up
## chr1p13 0.0019569 0.0063113 0.5294143 2.484238 0 135 EPS8L3 GSTM5 NTNG1 RAP1A CASQ2 STXBP3 CEPT1 VAV3 WNT2B RSBN1 TSPAN2 DRAM2 PIFO SLC25A24 CTTNBP2NL DENND2C WDR47 CD58 CHIAP2 GSTM3 TMEM167B HIPK1 SLC22A15 KCND3-IT1 C1orf162 KCND3 LRIG2 KCNA10 KCND3-AS1 RNU6-151P SORT1 SLC16A1 TRIM33 RNU7-70P ST7L KCNA2 TSHB MIR197 CD101 RNU6V CSDE1 CHI3L2 FAM102B SYPL2 GNAI3 KCNC4 GPR61 C1orf194 PHTF1 UBE2FP3 SLC6A17 AKR7A2P1 NRAS AMIGO1 CLCC1 GNAT2 SIKE1 SLC25A24P1 RNU6-817P AKNAD1 up
## chr20q11 0.0020704 0.0063113 -0.5067564 -2.456651 0 159 SNORA71D NECAB3 SNORA71C SNHG17 ACTL10 SNORA71B CEP250 C20orf144 CDK5RAP1 SNORA71A SNTA1 TTI1 GSS EIF6 ACTR5 TM9SF4 E2F1 ARHGAP40 ZNF341 ERGIC3 HM13-IT1 RALY ROMO1 AHCY GGT7 NFS1 DYNLRB1 LBP CHMP4B SNHG11 VSTM2L SPAG4 SNORA60 TPX2 MMP24 DNMT3B RN7SKP173 TGIF2 SCAND1 PLAGL2 EFCAB8 RPN2 MIR499A CBFA2T2 PDRG1 DLGAP4 PIGU NCOA6 CPNE1 EDEM2 ITCH-AS1 AAR2 MAP1LC3A TRPC4AP RNU6-759P HM13 RPRD1B down
## chr1p22 0.0019157 0.0063113 0.5594384 2.414377 0 81 TGFBR3 PKN2 EVI5 WDR63 SPATA1 RN7SL653P CLCA2 SH3GLB1 GBP7 CTBS ZNF326 DR1 RNU4-59P LPAR3 LRRC8C HS2ST1 MIR4423 ARHGAP29 RPF1 MCOLN3 CCDC18 TMED5 RNU6-125P MTND4P11 RBMXL1 GTF2B C1orf146 RN7SKP272 LMO4 HMGB3P9 CCNJP2 SSX2IP GBP6 BCAR3 GLMN ZNF644 ODF2L GBP4 CHCHD2P5 C1orf52 COL24A1 BTBD8 PHKA1P1 up
## chr15q21 0.0019417 0.0063113 0.5333489 2.395960 0 102 SEMA6D GCOM1 DTWD1 TRPM7 CNOT6LP1 EID1 TMOD3 ZNF280D FGF7 TCF12 NEDD4 POLR2M COPS2 TMOD2 ADAM10 FAM227B MYZAP AQP9 HDC BLOC1S6 RNA5SP395 SLC30A4 UNC13C DUOX2 AP4E1 USP8 MNS1 RSL24D1 MYO5A DMXL2 GATM SHC4 SPG11 CCPG1 RNU6-844P USP50 RNA5SP394 MAPK6 SECISBP2L GLDN RN7SL494P ATP8B4 RN7SKP95 ARPP19 RFX7 PIGB SPPL2A SLC28A2 GALK2 ALDH1A2 HNRNPA3P11 FBN1 CGNL1 PYGO1 up
## chr13q21 0.0019268 0.0063113 0.7262163 2.349026 0 23 DACH1 RPL35AP31 PCDH9-AS4 PCDH9-AS2 TDRD3 RPL21P109 PCDH9-AS3 PCDH17 PCDH9 DIS3 MZT1 PIBF1 up
## chr6q23 0.0019342 0.0063113 0.5723879 2.345874 0 61 VNN3 EPB41L2 TCF21 VNN2 STX7 AKAP7 IFNGR1 SMLR1 SGK1 MYB TBPL1 LINC00326 IL20RA RNA5SP219 MAP3K5 LINC01010 VNN1 MYB-AS1 BCLAF1 RN7SL408P LINC00271 PDE7B CCNG1P1 MED23 LINC01013 MOXD1 TMEM200A SLC2A12 ENPP1 ARG1 up
## chr3p24 0.0019342 0.0063113 0.5746368 2.293937 0 54 TGFBR2 NEK10 RBMS3 ZCWPW2 RBMS3-AS3 EFHB TBC1D5 UBE2E2 RBMS3-AS2 RARB AZI2 ZNF385D-AS2 RNU6-342P ZNF385D ZNF385D-AS1 KAT2B SALL4P5 NR1D2 RAB5A RBMS3-AS1 PLCL2 THRB CMC1 RPL31P20 RPS12P5 RPL15 PP2D1 UBE2E1 THRB-IT1 TOP2B FAM96AP1 MESTP4 up
## chr6p21 0.0020202 0.0063113 -0.4363798 -2.292661 0 296 BRPF3 MAPK13 ABCC10 AARS2 UQCC2 TJAP1 CUL9 FOXP4 GTPBP2 CUL7 CCDC167 TTBK1 TBCC YIPF3 MUC21 HMGA1 HSP90AB1 XPO5 ITPR3 DNPH1 PGC TMEM63B PEX6 CMTR1 SLC35B2 CLPS CNPY3 MRPL2 RRP36 CLPSL1 SRPK1 ARMC12 MRPL14 RPS10 UHRF1BP1 SPDEF ZNF76 PTK7 VEGFA TBC1D22B DLK2 POLR1C BYSL LHFPL5 NFKBIE PPP2R5D FRS3 IP6K3 MAD2L1BP ETV7 RPL7L1 MIR4641 MED20 NFYA SNRPC TAF8 DEF6 MRPS18A MEA1 SAYSD1 POLH GUCA1B PPIL1 MSH5 USP49 BAK1 KCNK5 PRICKLE4 SCUBE3 PACSIN1 FANCE BTBD9 CLPSL2 UNC5CL RPL24P4 CPNE5 MTCH1 C6orf132 RNU6-761P KLC4 GGNBP1 NCR2 SFTA2 RPS2P28 RPL3P2 LEMD2 RN7SL403P KLHDC3 RPL10A BRD2 ZBTB9 SLC26A8 TNF PPARD TEAD3 GLO1 HSD17B8 C6orf223 PPP1R10 RNF8 GNMT CCND3 down
## chr7p13 0.0020747 0.0063113 -0.6129929 -2.288790 0 35 TBRG4 ZMIZ2 SNORA5C DDX56 CCM2 YKT6 SNORA5A BLVRA POLD2 TMED4 SNHG15 DBNL POLM PPIA TUBG1P NUDCD3 URGCP RASA4CP MYO1G POLR2J4 SPDYE1 down
## chr19q13 0.0020202 0.0063113 -0.3985728 -2.263861 0 769 SYNE4 DHX34 FBXO46 SUPT5H ZBTB45 EXOSC5 CADM4 PRR12 SIPA1L3 ERCC2 C19orf48 MYPOP IRF3 EMC10 PIH1D1 SCAF1 BCL2L12 KCNC3 CNTD2 TIMM50 CAPN12 CATSPERG PNKP LMTK3 TMEM86B POLD1 WDR62 ZNF526 BCAT2 LSR SAMD4B EML2 THAP8 SYMPK MAP3K10 CLASRP OVOL3 ZNF628 SHKBP1 PPP1R37 PAFAH1B3 SLC7A10 QPCTL KLC3 HAUS5 ETFB SRRM5 FAM98C ISOC2 PPP6R1 TMEM238 U2AF2 LRFN3 SPINT2 FAM71E1 ZBTB32 MED25 TRAPPC6A PTOV1 GRAMD1A NAT14 MEGF8 VSIG10L PRR19 TOMM40 CCDC9 GSK3A AKT1S1 DLL3 UBE2M MARK4 ZNF444 CLPTM1 IGFL1P2 CCDC61 JOSD2 NUP62 TMEM147 SNRPA RINL IRGQ NFKBIB TNNT1 PSMC4 CA11 ZNF579 MRPS12 PRKD2 TRIM28 GRWD1 SPHK2 LINC00665 PDCD2L UBE2S CIC GYS1 CBLC RBM42 ATP4A TMEM190 ZNF865 LIG1 ZC3H4 IRF2BP1 ARHGAP33 HNRNPUL1 CNFN FIZ1 RN7SL566P KMT2B ASPDH BAX AKT2 FBL CYTH2 ALDH16A1 SYT3 DYRK1B PLD3 MYBPC2 SBK2 ZNF324B PPFIA3 NOSIP YIF1B PAF1 XRCC1 C19orf47 ZNF613 ZNF574 B3GNT8 SLC27A5 ZNF787 CHMP2A CEACAM1 GGN EPN1 SNRNP70 RN7SL789P ECH1 STRN4 ZNF581 ZNF541 CCDC106 PRRG2 LETM1P2 TBCB SDHAF1 TEAD2 ZNF580 FLT3LG HPN-AS1 ALKBH6 HPN CTU1 ZNF296 PLEKHG2 PAK4 TBC1D17 C19orf81 RUVBL2 PRMT1 PPP1R12C SNORD88A RN7SL693P TPM3P9 ZSCAN22 CCDC97 NAPSA GPI ZNF784 ZNF274 RPS16P9 RPS16 TMEM160 HSPBP1 GEMIN7 PTOV1-AS1 FAM83E COX6B1 BLVRB BCKDHA RAB4B MIR4323 POLR2I MIR320E KPTN APLP1 NPAS1 SBSN ZNF649 ZSCAN1 LHB BRSK1 MAP4K1 TMEM91 POU2F2 MAMSTR DEDD2 RPL31P60 LIN37 LRFN1 C19orf73 ZNF446 WDR88 SYNGR4 PPP1R13L LIN7B USF2 PSMD8 BCAM PPP2R1A ZNF428 NFKBID SARS2 PHLDB3 MED29 BBC3 ZNF544 SAE1 ZNF524 TPM3P6 ZNF324 NKPD1 SIX5 IGLON5 FKRP ZNF419 AP2A1 KLK14 ZNF577 HNRNPL BLOC1S3 GAPDHS RN7SL364P KDELR1 SMG9 ZNF671 VN2R19P PRPF31 SLC1A5 ZNF837 OPA3 RN7SL34P IL4I1 RPL28 RNU6-1337P MBOAT7 ZNF146 SPACA4 LIPE CD3EAP ETV2 ZNF584 ZSCAN18 ZNF497 IGFLR1 NAPA EIF3K NUMBL MZF1 ATF5 NUDT19 KLK13 BCL3 NTF4 SERTAD3 FBXO27 IFNL3P1 RELB ZNF71 SCGB2B3P GPATCH1 U2AF1L4 KLK12 C19orf33 EGLN2 down
## chr18q21 0.0019342 0.0063113 0.5110374 2.263750 0 94 SERPINB2 CCBE1 SERPINB11 TCF4 MAP1LC3P CCDC68 SMAD4 SERPINB7 RNU6-742P RNU6-708P MAPK4 SERPINB3 DYM ZBTB7C WDR7 LOXHD1 KDSR TXNL1 RNU6-142P PIAS2 ACAA2 C18orf54 SERPINB10 VPS4B SERPINB13 RNF152 SMAD2 ONECUT2 ATP8B1 MIR4744 DCC ZCCHC2 POLI KATNAL2 GRP RNF165 CTIF up
fgsea_plot(fgsea_res$res_c2, pathways_title='C2 curated genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------------------------------------------ ---------- ---------- ----------- ---------- ------------- ----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0019920 0.0137182 -0.6674565 -3.491715 0 308 ZNF692 TRAF2 NPM3 ZBTB7B KCTD13 EIF3B ABCC10 INTS1 FBXO46 SMG5 RHBG SNAPC4 SH3BP5L FBXL19 DPH7 FBXL18 USP21 PPM1G ZMYND19 QTRT1 UQCC2 CAPN15 ANKRD13D SRCAP GIGYF1 UBAP2L SMARCA4 PHKG2 ATXN2L TNK2 CUL9 ZMIZ2 ABCF3 ERCC2 MYPOP SRRT FBRSL1 LARP1 SETD1A TCF3 SCAF1 LSM14B RCC1 ZNF598 CUL7 KMT2D ATAD3A SLC39A3 DENND4B AGRN MRPS25 GRIPAP1 TMEM86B MARK2 ZNF316 ZNF646 SLC12A9 PUS1 MOGS ABCA7 SYMPK AP5Z1 TRABD CC2D1B CLASRP GAS5 PHPT1 STK11 ZDHHC24 LRCH4 SNHG3 ATAD3B XPO5 RTKN U2AF2 MAP2K2 GPC2 RANGAP1 HSF4 PDXP CALR CACTIN NEURL4 ZNF202 MIIP CMTR1 DRG2 GFER DAZAP1 ZNF444 ARMC6 TECPR1 NUP62 AP5S1 C7orf26 DDX11 TRRAP HIP1R POLM ILF3 PABPN1 HDAC10 RNPS1 ENGASE SPHK2 EVI5L CIC SETDB1 SPPL2B LLGL1 R3HDM4 FBXO44 SZT2 ACIN1 TBC1D22B APBA3 TMEM259 PQBP1 MEF2D WASH3P PPRC1 TMEM63A KHSRP ARPC5L CSNK1G2 RASSF7 COPS7B PTBP1 LPAR2 TNPO2 MBD3 EPN1 SNRNP70 REXO1 TMEM201 KLF16 ZNF580 ARHGEF11 CDK3 HNRNPU GGA1 PICK1 GATAD2A MSTO1 URB2 FANCA PPP1R12C SRRM2 FXR2 L3MBTL2 HPCA CNTROB GRAMD4 LIMD2 MAPK8IP3 TCHP PIP5K1A ZC3H7B MTOR SBNO2 TRMU DAGLB IL18BP CDC42SE1 KAT8 PPP6R2 RAD54L2 FURIN POLR2F SUPT7L BRD1 TAF1C RANBP3 KCNK5 RBM14 ZNF524 RNF207 CSNK1E down
## LI_AMPLIFIED_IN_LUNG_CANCER 0.0019569 0.0137182 -0.6725150 -3.279182 0 167 EEF1D MDK CRABP2 P4HB PDCD6 CDK2AP2 HDGF HSPA5 SYNGR2 ERBB2 TSTA3 CCT3 SCNN1A ABCC3 UBE2C PHLDA2 SPINT1 NME4 FGB APRT TRAF4 KRT7 LGALS3BP HSPB1 CCT5 HAX1 JTB ODC1 CBX3 TALDO1 SLC22A18 LDHB RPL38 TUFM UGDH UBE2I RPL37 SPINT2 UCHL1 HSPD1 CALR DAP SOX4 PABPC1 ENO1 RPL8 SNRPE ALDOA NME1 ATP1B1 EIF3C AKR1C1 TRIM28 DSP DPP7 RPS10 NQO1 VEGFA EEF1A2 IDH2 HSP90B1 SFN PSMB4 PTPRF MUC1 LAPTM4B SDHA PRDX4 RPS2 RPL37A HPN MSLN RPS20 ERBB3 YIF1A CDH1 TRIM2 PKM PFKP GPI SLC7A5 RPS16 TOP1 AKR1A1 JUP STAT1 CD46 RPL27 RPL30 RPS21 PSMD8 DDOST RPL31 RPL27A RPS27 KDELR1 RPL35 RPL28 ZNF146 MARCKSL1 SPP1 RPL13 CANX CLDN9 RPL7 GALNS PGD TXNRD1 ENC1 CKAP4 PLP2 MALL RPS7 XBP1 SNRPD2 UQCRH down
## CAIRO_HEPATOBLASTOMA_CLASSES_UP 0.0018587 0.0137182 -0.5782584 -3.208268 0 560 ZNF696 EEF1D NPM3 SNRNP200 NCLN P4HB EIF3B STK25 PARP1 ABCF2 PDCD11 GPS1 NR2F6 DTYMK TBRG4 PFAS CIAO1 MRPL12 DDX27 GTF3C2 UTP14A PRPF6 RFXANK TIMELESS CYC1 CAD RANBP1 SMARCA4 CCT3 NUP210 POLR2D FARSA NCL UBE2C MYBBP1A RCC1 TRAP1 MAN1B1 CDT1 APRT ATIC DNMT3A IMP4 MYL6B PDIA4 FAM136A PNKP CCT7 RRS1 POLD1 DDX56 MLST8 PTP4A3 NHP2 LSM4 EIF2B4 SSRP1 PUS1 AARSD1 CCT5 ODC1 THAP4 TUBG1 AP1G2 EPCAM DDX41 ERGIC3 CBX3 RNASEH2A AAMP MAD1L1 MCM7 NAT10 HMGA1 ARID3A HSP90AB1 HJURP CDK4 AHCY RUVBL1 AATF RNF126 MRPS7 CHAF1A KIF22 DGKD PDIA6 HSPD1 AURKB MCM2 CCT6A EXOSC2 DNMT1 CDCA8 DAZAP1 ENO1 CCT2 BIRC5 SMARCB1 E2F5 CCNF RPL8 CPSF6 TRRAP ALDH18A1 NME1 PAXIP1 ILF3 GRK6 APEX1 NLE1 CRELD1 KIF18B MCM10 TRIM28 SRPK1 MCM4 NT5DC2 MAZ NOP56 POLR3E ILF2 TOMM34 TPX2 SAP130 UBE2S TPD52L2 NONO LIG1 CDC20 PLK1 MIS18A MMS19 PQBP1 POLR1C THOC5 CCNB1 CIZ1 GGCT FBL MKI67 KIF2C SMARCC1 DDX42 BYSL PRMT5 CHD7 GNL3 BZW2 SLC39A4 IMPDH2 BUB1 PSMB5 GART IPO4 POP7 TXNL4A CHCHD2 C1orf109 HDLBP KIF20A LAPTM4B RPN2 MAVS GINS4 MRTO4 PRDX4 CDC25A EIF4A3 RRM2 KIF15 NEK2 NOLC1 UPK3A C8orf33 OSBPL2 KPNB1 AURKA C1QBP RPL37A DDX39A GLDC LRRC59 NCAPG2 PHB RUVBL2 PRMT1 FANCA TOP2A CPNE1 CENPF SMC4 KIF4A AGBL5 GTF2F1 KIF14 PRKDC RPL36 CDC6 SNTB1 TSR1 RPS16 NUP85 CREB3L2 MRPS33 MRPL15 SUPT16H WDYHV1 HMMR PSPH PUF60 RPL11 PPAT PUS7 TGS1 TRMU RPL19 PRDX6 NDC80 SPAG5 MRS2 ASPM NCAPD2 CENPA SF3B3 NUP93 ACTR3B EIF5B NCBP2 RPS21 CDC25C GTPBP4 CIAPIN1 RPS6 DDOST EZH2 SAE1 BSG HMGB2 HEATR1 CCNA2 PTK2 KIF18A RPP40 ODF2 PRC1 SEC61G SF3A1 CCNE1 GINS1 SFI1 RFC4 BOP1 KDELR1 RFWD3 KIF11 CCT4 SPDL1 CCDC47 CDKN3 WDR12 RPL28 MCM3 LIG3 CPSF1 EIF3H RSL1D1 MAD2L1 CANX MTDH RPL14 DLGAP5 HUWE1 STOML2 KNTC1 PLIN3 COPS5 PLTP DNAJC4 CDK1 BUB1B EIF4E2 MRPS27 PSMF1 UTP6 TTK TAF12 ACLY HTRA2 IGSF1 PI4KA HSF1 NUSAP1 XRCC6 OLA1 MCM6 SNRPD1 UQCRH CHEK2 RPS3 RPL10A DGUOK GCSH LYRM4 CKAP5 UTP18 EMG1 CENPQ WDR3 SNRPB ENOPH1 NUP205 PABPC4 down
## SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 0.0019920 0.0137182 -0.6738433 -3.204889 0 138 MRPL12 MYBL2 TIMELESS UBE2C STIP1 E2F1 SHMT2 PKMYT1 CCT5 RNASEH2A NUDT1 HJURP TACC3 AURKB MCM2 FEN1 CDCA8 BIRC5 NME1 ORMDL2 KIF18B MCM10 MCM4 TPX2 UBE2S FOXM1 PTTG1 CDC20 PLK1 MIS18A CCNB1 CEP55 SLC52A2 MKI67 KIF2C BYSL TROAP BUB1 QPRT TUBA1C KIF20A CDC25A RRM2 KIF15 NEK2 ESPL1 AURKA DDX39A ZWINT SNRPC NCAPG2 EXO1 LMNB1 TOP2A CENPF KIF4A KIF14 POLQ SLC7A5 MRPL15 MELK HMMR NCAPH PSMA7 NDC80 SPAG5 ASPM CENPA NUP93 MRPS17 DSN1 GTPBP4 CENPE EZH2 APOBEC3B TXN CCNA2 XPOT PRC1 DSCC1 GINS1 HMCES RFC4 SNRPF KIF11 CDKN3 MCM3 GTSE1 MAD2L1 DLGAP5 STMN1 CDK1 BUB1B CCNE2 TXNRD1 TIMM10 TTK NUSAP1 RACGAP1 MCM6 down
## ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 0.0020661 0.0137182 -0.6657973 -3.150010 0 130 DPP3 TK1 MAPK13 DTYMK MYBL2 UBE2C E2F1 LSM4 PAFAH1B3 TMSB10 HMGA1 HJURP ASF1B TACC3 AURKB MCM2 FEN1 SLC25A15 SAC3D1 CDCA8 BIRC5 CCNF MRPS15 KIF18B MCM10 MCM4 CHAF1B TPX2 UBE2S FOXM1 PTTG1 CDC20 PLK1 DNMT3B CCNB1 CEP55 MKI67 KIF2C LRP8 BUB1 CELSR3 KIF20A GINS4 RRM2 KIF15 NEK2 ESPL1 ATAD2 AURKA ZWINT LMNB1 TOP2A CENPM CENPF SMC4 KIF4A KIF14 POLQ CDC6 MELK ACACA HMMR NCAPH NDC80 SPAG5 ASPM DHFR CENPA CENPE EZH2 SHCBP1 HMGB2 APOBEC3B CCNA2 PRC1 GINS1 DNA2 KIF11 SPDL1 GTSE1 MAD2L1 DLGAP5 HELLS CDK1 BUB1B CCNE2 TTK PAQR4 BRCA1 NUSAP1 RACGAP1 GMNN KIF20B CDKN2A STIL down
## WELCSH_BRCA1_TARGETS_DN 0.0020492 0.0137182 -0.6570725 -3.104861 0 127 EIF3B ALG3 PDCD11 SEC24C PWP2 GTF3C2 MGST1 AP3D1 CYC1 CAD UBAP2L RRP1B SMARCA4 PHKG2 CHD4 FARSA PMPCA RCC1 TRAP1 BMS1 ATIC POLD1 SSRP1 MOGS LMNB2 SRM EDC4 POLRMT NMT1 CDK4 FASN CDC25B AIMP2 CHAF1A SF3B2 HRAS MCM2 SOX4 DDX11 APEX1 MRPS12 NME3 SRPK1 BYSL HSP90B1 RASSF7 RPIA GALK1 HDLBP SNRNP70 CCND1 NOLC1 RAE1 FKBP4 AGPAT2 SCAP SLC7A5 RABEPK PPAT HK1 CDC37 MLEC PKN1 TAF1C POLG CLTA NUP188 CCNE1 SAFB BOP1 DANCR SLC1A5 CTPS1 TCOF1 SLC19A1 NUP214 KAT2A CKAP4 HSF1 SF3A3 GCSH BRD2 EMG1 RXRA PABPC4 down
## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0020492 0.0137182 -0.6743293 -3.094210 0 105 RHBDL1 RPUSD1 TELO2 MRPS34 CHTF18 NUBP2 TBL3 SNRNP25 CAPN15 MRPL28 MSRB1 AXIN1 RHOT2 KCTD5 NME4 ZNF598 RAB40C TSR3 FBXL16 DECR2 WDR90 NPRL3 ZNF213 PKMYT1 CLCN7 THOC6 EME2 POLR3K MSLNL UBE2I STUB1 ZNF205 PIGQ UNKL GFER WDR24 C16orf91 TRAF7 GNPTG NME3 WFIKKN1 JMJD8 TSC2 HAGH NTHL1 MPG METRN LMF1 CLDN6 PRSS27 RPS2 SPSB3 MSLN SRRM2 NDUFB10 GNG13 MAPK8IP3 TNFRSF12A SYNGR3 HAGHL KREMEN2 HCFC1R1 RHBDF1 MMP25 RAB11FIP3 RNF151 FAHD1 FLYWCH1 FLYWCH2 CLDN9 down
## MANALO_HYPOXIA_DN 0.0020284 0.0137182 -0.5914851 -3.065884 0 270 WDR4 BCS1L HMBS NCLN TELO2 PARP1 ABCF2 RRP1 LETM1 PFAS CIAO1 SLC25A10 FAM86C1 PWP2 UTP14A CAD RANBP1 RRP1B RPL39L SRRT URB1 NVL ATIC FAM136A RRS1 PKMYT1 PUS1 LMNB2 EBNA1BP2 ODC1 TUBG1 SRM TSFM NAT10 HMGA1 USP39 HJURP FASN ASF1B RRP9 SCLY POLR3K RUVBL1 AIMP2 CHAF1A SLC5A6 DDX23 TOR3A MCM2 FEN1 SLC25A15 EXOSC2 NOL12 ARMC6 METTL2B UMPS DDX11 CCNF POLD2 FANCG NME1 ILF3 NLE1 MRPS12 MCM10 GRWD1 MCM4 MAZ NOP56 TPX2 RBM28 UBE2S PCYT2 CLPB BYSL PRMT5 LRP8 GART AMDHD2 IPO4 POP7 PA2G4 GGT1 POLR2L PSME3 MRTO4 RSAD1 RRM2 NOLC1 C1QBP HNRNPU ZWINT URB2 PHB EXO1 DHCR7 PPIF POMT2 PAK1IP1 AKAP1 CDC6 TSR1 PRMT7 NUP85 MELK GEMIN2 PPAT DGCR11 DHFR FUS DDX19A PSMD11 NCAPD3 WDR74 GTPBP4 MCM5 SHCBP1 HEATR1 CCNA2 NUP188 TTLL4 RPP40 PRC1 CCNE1 GINS1 DNA2 BOP1 PAIP1 SPDL1 SLC1A5 C1orf112 WDR12 MCM3 MFN2 MAD2L1 CD3EAP TOP3A CTPS1 down
## WONG_EMBRYONIC_STEM_CELL_CORE 0.0020202 0.0137182 -0.5780709 -3.028750 0 318 CRABP2 DPP3 MRPL4 MAPK13 PARP1 DTYMK DAP3 MRPL12 PPM1G MYBL2 FARSA NCL NME4 RCC1 STIP1 PDIA4 FAM136A EIF6 POLD1 NHP2 LSM4 PUS1 CCT5 EBNA1BP2 NIPSNAP1 CBX3 ECHS1 NDUFS2 MCM7 NOP2 UGDH CDK4 NUP107 POLR3K RUVBL1 TP53 CHAF1A KIF22 AURKB TIMM44 MRPS2 NLN MCM2 DNMT1 IPO9 PABPC1 CDCA8 PPP4C ENO1 NDUFA11 BIRC5 CDCA5 CCNF SNRPA APEX1 TRIP6 ACAD8 RNPS1 MCM4 NT5DC2 BANF1 EIF3A NONO MRPL11 CDC34 HNRNPAB CDC20 PLK1 HNRNPA1 NTHL1 BAX PSMB6 FBL GNL3 TGIF2 THOC3 BUB1 TIMM13 PSMB5 GART NDUFB7 POP7 PA2G4 KIF20A PSME3 MRTO4 RRM2 CCND1 NEK2 FDPS AURKA TEAD2 GLDC ORC1 PHB RUVBL2 EXO1 LMNB1 PRMT1 TOP2A NDUFAB1 SMC4 KIF4A NDUFB10 CDC6 RPS16 MRPL15 RCC2 ERP29 E2F3 GEMIN2 NCAPH PSMA7 NDC80 SPAG5 POLR2F NCAPD2 HSPA9 ZIC3 MRPS28 MRPS17 RAB34 NCBP2 RAD23B MCM5 HMGB2 CCNA2 RPP40 CKAP2 LSM10 RPL27A HNRNPL RPS27 TMEFF1 KIF11 CLPP CDKN3 MCM3 SERPINH1 GTSE1 MAD2L1 RPL13 DARS2 MRPL37 DLGAP5 HELLS COQ3 STOML2 EIF3K TCOF1 EIF3I CDK1 EEF2 BUB1B TIMM8B SDHC BRIX1 CTNNA1 TTK PLK4 EMC8 NUSAP1 RACGAP1 UQCR11 COX5B SET GNPDA1 SNRPD1 UQCRH CHEK2 RPS3 RPL10A PSMD14 down
## WHITEFORD_PEDIATRIC_CANCER_MARKERS 0.0020747 0.0137182 -0.6589485 -3.023960 0 108 RECQL4 TK1 SNRNP200 DTYMK RRP1 MYBL2 UBE2C UBE2T E2F1 LMNB2 ODC1 UHRF1 PAFAH1B3 RNASEH2A MCM7 NUDT1 CDK4 ASF1B PSAT1 DNMT1 PON3 MND1 SOX4 CDCA8 ENO1 BIRC5 CDCA5 NME1 ILF3 MCM4 ILF2 TPX2 PTTG1 CCNB1 MKI67 BUB1 MLLT11 CDC25A RRM2 NEK2 ESPL1 ATAD2 AURKA ZWINT TOP2A CENPF SMC4 KIF14 POLQ RCC2 NUF2 MELK NCAPH GAPDH DHFR CENPA MCM5 CENPE CCNA2 CKAP2 ZNF367 PRC1 CDCA2 RFC4 TMEFF1 KIF11 MFN2 MAD2L1 DLGAP5 STMN1 CDK1 TTK PLK4 down
## SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 0.0020243 0.0137182 0.5679581 3.015555 0 331 LDB2 PLSCR4 TACC1 PROS1 RECK SGCB ROR1 LMO2 EML1 COLEC12 ECM2 RGCC ZEB2 PLN OLFML1 PECAM1 TCF4 TMEM47 CD93 AKT3 RCBTB2 TGFBR2 DAB2 MME DCN FOXN3 SOBP ERG GRK5 TM6SF1 TLE4 JAM3 SPARCL1 PTEN HPGDS SPON1 ZEB1 KCTD12 QKI CPA3 FERMT2 FLI1 TRPC1 SGCD MSR1 OLR1 SSPN HEG1 TIMP3 PRNP SDC2 DNM3 PARVA ST3GAL6 ATP10D BICC1 CLEC7A NUAK1 PALLD MEIS2 SLC2A3 PDGFRA EMP1 CPQ MYL9 GIMAP6 SGK1 LOX ELK3 ACSL4 PKD2 LMCD1 SERPING1 COL14A1 ENTPD1 NBL1 MS4A4A HEY1 PTPRM LUM ALOX5 GPR65 P2RY14 WWTR1 LAMA4 HMOX1 TMEM204 DSE IGFBP7 CLEC2B CALD1 MMP1 GAS1 ASPN ZFPM2 CFH EFEMP2 FAS MNDA MEF2C ENPEP EVI2A KCNJ2 MXRA7 FSTL1 EDNRA IL1R1 NID1 RASSF2 CPVL CASP1 SPARC SRGN MMP2 PDLIM2 TUBB6 ETV1 LAMB1 SNAI2 SERPINF1 NDN FGL2 TYROBP THSD7A INHBA CDH11 PRRX1 HTRA1 DPYD TGFB1I1 DACT1 SKAP2 TFEC MRC2 AXL COPZ2 SLC7A7 ANGPTL2 F2R PDGFRB COL15A1 GPNMB IRAK3 GIMAP4 MAF CRISPLD2 SMAD7 MFAP5 RCAN2 EVI2B FBLN2 CTSK CTSS ANXA1 FBN1 ITGBL1 CCR1 LPXN NID2 MAP4K4 ARHGEF40 LDLRAD4 COL16A1 CCND2 RARRES2 ACKR3 GLIPR1 OLFML3 C3AR1 MMP11 LRRC17 TGM2 TRIM22 XYLT1 CELF2 EMP3 COL4A2 COL4A1 HSD17B6 PTPRC GFPT2 COL6A1 NOX4 CD53 COL6A2 up
## SANSOM_APC_TARGETS_REQUIRE_MYC 0.0020040 0.0137182 -0.6008670 -2.997896 0 209 SMPD4 WDR4 SMYD5 TK1 TELO2 PPP1R14B GTPBP3 DTYMK POLR1A ZMYND19 QTRT1 METTL1 TIMELESS CAD MYBBP1A ANKRD39 PPAN THOP1 NELFA MRPL38 D2HGDH SAPCD2 CCT7 WDR34 ZNF213 NHP2 WDR62 SHMT2 LMNB2 KNOP1 NTMT1 SRM SRD5A3 DPH2 RNASEH2A MCM7 LHPP CDK4 RRP9 TP53 PTOV1 NFS1 GAS8 SLC35B2 SOX4 DRG2 ZNF444 SIGMAR1 LDB1 GIPC1 NME1 NBEAL2 GRWD1 NOP56 METTL2A USP20 SYTL1 RAD23A TRMT61A CCDC86 FHOD1 GAR1 POLE RANGRF FBL SMARCC1 ZSWIM3 TGIF2 DUS3L LRP8 MBD3 SLC29A2 MUS81 SHMT1 NOLC1 TXNRD2 ARX PMM1 POMT1 ZBTB48 DDX49 AAR2 RCC2 TNFRSF12A RAD54L SIVA1 HAGHL AAAS TMEM141 GEMIN5 RASSF4 ATG9B RPL31 CINP NFKB2 HES6 SNRPF HIRA RNASEH2C SETD4 CCT4 MCM3 SLC1A4 EXOSC1 GTSE1 NOL8 ALKBH2 ATRIP PDXK SFSWAP BUB1B KAT2A MVK EMC8 MAPK7 PCBP4 ADAT1 RNF157 down
## LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 0.0020367 0.0137182 -0.6035594 -2.986684 0 202 PYGO2 INPPL1 PC SLC4A2 CLPTM1L PMVK TDRKH DPP3 B4GALT3 MBD6 TMEM134 ABCF2 NDUFS6 FASTK TAF6 PDCD6 CCS HDGF CORO1B ADAR PRCC USP21 FADD PPP1R16A METTL1 EIF4G1 TSTA3 GCDH DENND4B POLR2H CCDC127 ALKBH4 PNN RMI2 CCT5 HAX1 JTB POLR2J CDK5 TSFM NDUFS2 YKT6 MCM7 NUDT1 NAT10 CDK4 PI4KB ZNF74 PMF1 KDM2A IGSF8 MED15 SLC12A7 DUSP12 PPP1CA MRPL9 CCT6A NKX2-1 DAP MAGEF1 CLCN2 ILF2 LY6E POLD4 SETDB1 RAD23A MRPL11 MRPL36 VEGFA DVL3 MAF1 PSMB4 LPCAT1 TUFT1 SDHA ZNF3 SSR2 ARHGEF11 AKT1 DHCR7 EGFR MRPL23 FIGNL1 CERS2 PARD3 MBIP COPS6 SLC39A1 PUF60 PIP5K1A SIVA1 GEMIN2 NUBP1 FAM131A SRD5A1 AGO2 PPP1R3D AIP DEDD NUMA1 TFDP1 MRPS17 P2RY6 MET FAM177A1 down
## LU_EZH2_TARGETS_UP 0.0020661 0.0137182 -0.5804929 -2.977755 0 257 TSPAN17 TLCD1 SHARPIN RPUSD1 PMVK PPP1R14B FOXK2 MFSD3 PUSL1 PSMD4 PGAP3 PODXL2 CBR1 LONP1 BCAS4 AP1S1 C8orf82 TYSND1 IRF7 RPS6KB2 PIH1D1 COMTD1 MTX1 OXLD1 MYL6B LMTK3 LSM7 ZNHIT1 RMND5B MIEN1 TRIB3 SIGIRR THOC6 NUDT1 ETFB CLDN7 RUVBL1 ISOC2 STUB1 KRTCAP2 FAM71E1 TOR3A ENSA F11R PDXP FGA WASH2P JOSD2 S100A2 NENF SNHG11 TRIM16L PEX16 TCF20 HSD11B1L TRIP6 NME3 PFKL PLEKHJ1 LAMTOR4 OGFR ELFN2 MEX3D BOK PSMC3 DLK2 CYB561D2 ISG15 ZDHHC16 RPAIN WDR83 SCAND1 MPG THOC3 ZCCHC3 AMDHD2 ZP3 LPCAT1 ATOX1 TUFT1 GANAB PRDX4 NOLC1 TRAPPC12 IFI35 KLHL35 ZMAT5 ZNF629 CSK UNC45A CPM RPL36 AHSA1 NCAPH2 ENDOG C1orf50 GALT NUDCD3 MAPKAPK3 RPS19BP1 HAGHL C1orf210 HCFC1R1 TMEM141 VOPP1 TESK1 DPM3 WDR45 WDR74 SNCG RHOF HES4 TRIM47 MGMT MKNK2 MAFA ODF2 SDC4 PAGR1 PCK2 CDK9 S100A13 APOBEC3F ALKBH2 RPL13AP6 S100A6 ACO2 DDIT3 ECHDC3 PSMB10 SDHC CCDC107 PSMB7 AKR1C2 RGS19 PITX1 SURF2 RPLP0P6 KLHDC9 CBY1 ZNF133 HBQ1 KLHDC3 OCEL1 SERF2 down
## SABATES_COLORECTAL_ADENOMA_DN 0.0019841 0.0137182 0.5781630 2.976573 0 274 BTNL8 SEMA6D LYVE1 B3GALT5 OGN JAM2 BCHE GHR ABCG2 CD36 ADH1B ABI3BP SLC51B RUNDC3B COLEC12 MAMDC2 ASPA ABCA8 PDZD3 AOC3 TMEM100 FABP4 CDH19 MFAP4 TRPM6 FAM13C PRIMA1 MEIS1 SCN7A EFEMP1 NR5A2 FAM107A MEOX2 RBM24 PLP1 SYNPO2 LMOD1 GPM6B CLEC3B KCTD12 MT1M FBLN1 CA2 ATP1A2 WNT2B PDE6A CPNE8 RAB3B RERG TMOD2 PTPRR CTSG HOXD10 CHRDL1 UNC5C VIP MYLK RSPO2 SLC26A2 DPT CNN1 MYH11 GUCA2A BRINP3 SLC22A4 LIFR CA4 TMCC3 OSR1 C7 SFRP1 HSD17B2 ITIH5 MS4A8 CXCL12 TUSC3 COL14A1 ANGPTL1 ZNF536 GPX3 EDIL3 LRRK2 MEP1B EPB41L3 NAP1L3 SCARA5 CHP2 PCK1 BEND5 ZNF483 SV2B IGF1 PHLPP2 ZNF667-AS1 ADCY2 ASPN RSPO3 CFH RFX6 PCDH9 CNTN4 SETBP1 USP2 CYTL1 BEST4 TPH1 CDKN2B FXYD1 TNS1 BMP5 WASF3 CHGA FLRT2 THRB GLDN CPB1 CCL23 PLAC9 NRXN1 NLGN4X NDN NAALADL1 SLC4A4 EPHA7 HAPLN1 KCNIP4 TMEM200A CCDC80 EDN3 TRGC2 ENPP6 EPHA3 up
## HOLLERN_EMT_BREAST_TUMOR_DN 0.0020000 0.0137182 -0.6316228 -2.944253 0 114 SPTBN2 BSPRY RAB25 EVPL TMPRSS13 STAP2 SPINT1 PKP3 TFAP2C ELMO3 TMEM79 EPHA1 LSR EPCAM CRB3 ST14 AP1M2 KLC3 CLDN7 EPPK1 SPINT2 C1orf56 TMEM184A RNF43 HIP1R OVOL1 DSP CBLC LLGL2 EPS8L2 GRB7 PTPRF GRHL2 GRHL1 CEACAM1 ILDR1 TMEM54 ESRP2 PRSS8 TNK1 ERBB3 CDH1 PPIF ESRP1 STARD10 EFNA3 MAP7 JUP C1orf210 ARHGEF16 DEDD2 PLEKHG6 IL17RE MAL2 CCDC120 TJP3 CDH3 CELSR2 down
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 0.0019881 0.0137182 0.6010322 2.939624 0 184 CAV1 PLSCR4 PROS1 SLIT2 RUNX1T1 CCDC50 BNIP2 REEP1 FBXL3 OLFML1 MYH10 TCF4 PMP22 DAB2 DCN EFEMP1 RBMS1 EXTL2 PSIP1 MAGI2-AS3 PTPN21 PTPN12 WNT2B MAP3K8 FRAS1 FERMT2 AP1S2 DOCK11 POLR2M KPNA5 FBXL7 RERG BNC2 GABPA RBFOX2 DDR2 TIMP3 EFHC1 PRNP SOCS5 ZYG11B UFSP2 SDC2 UBE2E2 CSGALNACT2 FER CRYBG3 C1orf198 RAB11FIP2 WDFY3 SOX6 HOXD8 MCOLN3 BLOC1S6 TGFB2 PKD2 SLC30A4 RNF146 TTC28 TAOK1 CFL2 LAMA4 DSE ATP2B1 ZNF483 CALD1 RGL1 KAT2B GAS1 ACSS3 FLNC ZFPM2 MNDA WASF3 GCA FAM13B SPRY1 RCHY1 CDON FAM153A FLRT2 CPVL ZKSCAN8 TMEM237 CBR4 BEX4 SIRPA OSTM1 NDN SBSPON CLIP4 CCDC80 HBB SPAG9 LXN NKX3-1 HTRA1 TCEAL1 PREPL SOD2 DPYD SPOCK2 GPNMB PROCR MAF TIAM1 WT1 CTSK TSPYL1 FBXO21 TMX4 TMEM45A ZBTB20 PTGS1 WNT5A CELF2 SRGAP2 ATP11C FZD7 CAP2 BTF3L4 GPRASP1 DOK5 NR2F1 KIF1B GPRASP2 up
## LI_DCP2_BOUND_MRNA 0.0020080 0.0137182 -0.6805359 -2.937781 0 78 DUS1L EEF1D NDUFS8 APEH MRPL12 CYC1 FAM50A MTX1 APRT TACO1 NARF DCXR DEAF1 TRIB3 SCO2 ETFB CHAF1A MAP2K2 CUEDC2 NDUFA13 PSMC5 ENO1 NQO2 MRPS12 NT5DC2 NOP56 EDF1 SAP30BP PSMC3 HSP90B1 NDUFB7 CHMP2A POLR2L EIF3G MRTO4 TSPAN31 TPR RUVBL2 FAHD2A PI4KAP1 MRPL23 FLII SRRM2 down
## SWEET_LUNG_CANCER_KRAS_DN 0.0020833 0.0137182 0.5465663 2.936802 0 391 CAV1 SNCA LYVE1 FHL1 TEK OGN ANGPT1 RECK SESN1 CYP2F1 SORBS1 ADH1B EDNRB LMO2 CDO1 ADARB1 CALCRL TBX3 ALDH1A1 ADCY8 EMCN ANKRD1 RHOJ CYP2B6 ACKR4 TCF4 CD93 PMP22 FOXF1 ACVR2A CLIC4 MEIS1 DCN SCN7A EPS15 INMT SPTBN1 TCF21 PTPRB GRK5 MEOX2 GPC3 SASH1 CDH5 LEPR GPM6B KLF4 SPARCL1 FGF7 ACTC1 CLEC3B ACVRL1 PSIP1 ZEB1 KCTD12 FMO3 SOX17 CA2 QKI ATP1A2 TEKT1 PKIA NDRG2 RAMP2 FERMT2 PEG3 ADRB2 MYH1 POLR2M HOXA5 CFD MACF1 SSPN AHNAK PTPRD OMD RASIP1 IL6ST TIMP3 CACNB2 HEPH DPT KITLG GNB4 SEMA3C TWSG1 CCRL2 CDK14 SMARCA2 SIAH1 TIE1 TUBA1A MPDZ TNFRSF19 MYH11 VWF KLF9 EPAS1 PAPSS2 BCL6B SMAD6 LIFR KANK3 NUMB ALDOB PDGFRA VAMP3 MYL9 ACTA2 PDLIM1 LOX PKD2 LTBP4 SERPING1 KALRN BPIFB1 CLDN5 TAGLN GPX3 LAMA2 MS4A4A MYB NFIB ENPP2 ARHGEF3 MYO1B CA3 HEY1 GNG11 TBX2 MYL3 ART3 LATS2 EPHA5 PTGIS WWTR1 FOXF2 PCK1 TJP1 EMP2 PPP1CB SPEF1 ANTXR2 GSTA3 CFH NR2F2 NPR3 FAS MNDA MEF2C TPH1 TFRC FXYD1 STMN2 UPK3B VCL ICAM2 NID1 SCGB1A1 SPARC CIDEC PLAC9 SRGN ETS2 ANKRD10 JUN SLC10A2 PRX ZMYND11 LAMB1 INPP5A SLCO3A1 NDN FGL2 RAB28 CDH11 ENG HBB MGP DENND4C BDNF PTCH1 GSN KRT4 PGM2 ACE FGF9 IL1B ETS1 ANGPTL2 GNG2 RAB12 TFPI SPOCK2 PDGFRB GIMAP4 SPCS3 TIAM1 THBD NPNT PROM1 CES1 MFAP5 XIST CNTN1 up
## NIKOLSKY_BREAST_CANCER_1Q21_AMPLICON 0.0019685 0.0137182 -0.8125862 -2.926683 0 33 FLAD1 EFNA4 PYGO2 THEM5 PMVK SLC50A1 TDRKH ZBTB7B PBXIP1 MTX1 DCST2 DCST1 TRIM46 KRTCAP2 RORC MRPL9 ADAM15 OAZ3 THEM4 MUC1 THBS3 FDPS GBA LINGO4 RUSC1 EFNA3 LENEP DPM3 down
## CUI_TCF21_TARGETS_2_DN 0.0021739 0.0137182 0.5117470 2.919822 0 780 DACH1 TGFBR3 LDB2 PLSCR4 CRIM1 TACC1 TEK LRCH1 C1QTNF7 CLEC1A PROS1 JAM2 ST6GALNAC3 MBNL2 SORBS1 CD36 EDNRB MYCT1 CAV2 SOX7 LMO2 SNRK EML1 COLEC12 CALCRL TBX3 EMCN ZEB2 GRM7 KLF3 ARHGAP31 SSBP2 FABP4 RAP1A DOCK4 AMOTL1 DIAPH2 VGLL3 FAM13C TGFBR2 DNAJB4 MME USP12 FRYL SCN7A SH3GLB1 STXBP3 ARHGAP28 CALM1 SEMA5A TMOD3 SERINC1 PREX2 TCF21 ERG PTPRB TTLL7 HIPK3 ARL13B GRK5 UACA RBMS1 GINM1 PRKAA1 WWC2 GALC TLE4 CYYR1 CDH5 CXCL3 DYNLT3 PLXDC2 KLF4 PRKG1 LRRC28 DGKH DENND6A FGD5 RAPGEF4 ITGA8 TCP11L2 USP33 SOX17 QKI CTBS PTPN12 BMPR1A FERMT2 CPNE8 RORA EFNB1 STARD8 FLI1 TRPC1 MAGI2 POLR2M FRY LGALSL TLR4 ZBTB8A MACF1 TRAK2 RERG APBB2 ZDHHC14 AHNAK CHPT1 LZTFL1 ITSN1 GIMAP8 ARHGEF26 B3GNT2 KIAA0355 FAM76A IL6ST TSPAN2 TBC1D1 ZFYVE16 TIMP3 ACAP2 KITLG PTPRG SDC2 ZBTB7C MOSPD2 SLAIN2 LYZ ABCA5 USP46 CTTNBP2 ARHGAP24 CCRL2 ARHGEF15 PLD1 MTMR6 ARHGAP29 DPYSL2 BTBD3 PTGER4 OSBPL8 RNF11 PARVA CLEC14A DNAJB14 FGD4 ZNF175 EPAS1 FBXO3 ABCB1 CSGALNACT2 CCDC82 SGIP1 ST3GAL6 PDE2A UBR3 LIFR DST PALLD LMBRD1 KANK3 TMCC3 ULK2 KANK4 RNF13 RNF103 ABLIM3 SLCO2A1 SLC2A3 VIM BTNL9 CTDSPL PPIP5K2 ADAM9 GIMAP6 FOXN2 SGK1 SNAP23 SLC12A6 HEATR5B ANXA4 PLCL1 IQGAP2 ACSL4 MBD5 AGO4 SYNJ2BP MMRN2 PLCE1 LRRFIP1 TMED5 SNAPC3 CDC14A CSGALNACT1 FAM49A AP4E1 ZBTB44 DMXL1 SEMA3G ROCK1 MYO1B MTMR2 RIN2 DKK2 C18orf54 PELI2 SOS2 TAOK1 CEP85L ART3 LATS2 WWTR1 CYP20A1 SLC35A5 INO80D SACM1L RIOK3 FRMD6 TMEM64 TMEM204 VSTM4 TPM1 ING3 SERINC3 SCHIP1 SAMD8 LIMS1 DCDC2 MBNL3 PCDH17 KDM4C TMTC1 LIPA HHEX NFIL3 MCC ARHGAP17 CD59 TXNIP ELF1 TTC14 BACE1 UBE2Q2 FUT11 PRR15 EBF1 KDM6A DTNA CCPG1 MTSS1 NPR3 C6orf120 STRN FOXC2 TBC1D12 VPS54 MNDA MEF2C PLEKHG1 RICTOR ARL8B RCAN1 SYNPO CSNK1G3 RAPGEF2 CLIC5 BBX MTM1 RALB HLX VCL ICAM2 PIK3CA SECISBP2L ATP8B1 TRIB2 NID1 TRIM23 PDGFB MYADM IKZF5 GTF2A1 RC3H2 NEBL JAK1 MAP3K2 C8orf58 LNPEP HS3ST6 ARID4A IGIP RPS6KA5 SRGN PTAR1 PDLIM2 AGTR1 YIPF4 MED23 ARAP2 CRK PUM2 TSPAN8 FAM135A PRX SIRPA NOSTRIN SH2B3 PARD3B CDC73 ATXN7L1 AGFG1 TMEM30A HEY2 STAG2 RASSF9 HSDL2 PLSCR1 GPRIN3 THSD7A PTPRO SLC36A4 DEGS1 SLC2A12 CYBB VSIG10 RASL11A COL12A1 IL13RA1 NTN4 TMBIM1 GSN ARMC8 DBT HTRA1 RFK MPP5 PGM2 PDE4B B3GALT2 THBS1 PRKCH CBL TEX2 MSRB3 PCMTD1 up
## LIM_MAMMARY_STEM_CELL_UP 0.0021739 0.0137182 0.5346428 2.915178 0 446 CAV1 SNCA FHL1 VIT TGFBR3 TACC1 PROS1 SVEP1 JAM2 SLIT2 LIMA1 CNRIP1 SNTB2 RECK PRICKLE2 SORBS1 CD36 SRPX ABI3BP SGCB EDNRB OSBPL6 ITGA6 ADARB1 MAMDC2 ANKRD1 RHOJ CACNB4 SSBP2 FEZ1 AMOTL1 TCF4 TMEM47 VGLL3 NTF3 AKT3 ACVR2A SLIT3 MME SEMA5A SOBP CTNNAL1 DZIP1L GPC3 EOGT JAM3 LMOD1 LIMS2 THSD1 DLL1 CDH13 QKI TINAGL1 FERMT2 CPNE8 EFNB1 SCN4B STARD8 EFCAB1 MAOB TRPC1 PEG3 FOXP1 HEG1 ACTG2 RASIP1 MYLK IL6ST TIMP3 PRNP PAMR1 CNN1 MRGPRF PKNOX2 LRRC8C ARHGAP24 GNB4 SEMA3C TIE1 MPDZ BACH1 PPP1R3C ZNF423 MYH11 LRP4 EPAS1 RARB SGIP1 MYOCD LBH LIFR DST ITM2A OSR1 KANK4 GYPC LUZP1 SLC2A3 VIM ADAMTS1 CDC42EP2 RASL12 FABP5 AQP9 MYL9 ACTA2 STAC BMP1 PRICKLE1 ELK3 PCDH18 LTBP4 SERPING1 EBF3 NTRK2 COL14A1 RUSC2 TSHZ3 TAGLN DKK3 ENPP2 AGPAT4 SLC27A6 PPP1R14A RELN GNG11 TBX2 PDPN TMEM255B TMEM64 TMEM204 SCHIP1 MRVI1 JAG1 CALD1 ID4 FLNC DCHS1 ITGA1 MTSS1 ANTXR1 FAS MEF2C BVES NSG1 IL6 PCDHGC3 NRG1 FXYD1 CCDC3 CLMP TNS1 MXRA7 FAM216A FLRT2 TRIM29 MATN2 GPR176 SRGN MMP2 ZC3H12B SYDE1 TWIST2 SDK2 KRT14 MCAM CSRP2 RND3 FMOD PRX EEPD1 TUBB6 LAMB1 SNAI2 SERPINF1 SSH1 SLCO3A1 GRASP NDN SBSPON FGL2 KRT16 ARHGEF28 ISM1 FST CYGB RNF165 COL12A1 PRRX1 OXTR MGARP GSN HTRA1 GJA1 TENM3 PODN THBS1 TGFB1I1 SCARF2 EGR2 MSRB3 TPST1 STXBP4 IL17RD GNAI1 VSNL1 AXL IL1B ETS1 ANGPTL2 TSPY26P GJC1 ACER2 LCA5 PXDC1 ITGB1 FBXO30 LGR6 MEDAG COL7A1 IGFBP4 PTPRT SLC12A4 MSX1 RFX2 TNS4 KCNMB1 IL17B COL16A1 RBPMS up
## VECCHI_GASTRIC_CANCER_EARLY_UP 0.0018975 0.0137182 -0.5329644 -2.888299 0 403 EFNA4 ZFP41 PABPC1L DPP3 TK1 EIF3B PDCD6 AIFM2 TMED9 MYBL2 TRUB2 ALYREF CYC1 RANBP1 PFDN2 SMARCA4 MSRB1 CCT3 ITPA CEP72 UBE2C FAM50A TFAP2C TUBA4A BMS1 NELFCD GSS WDR90 KRT7 RRS1 COMMD5 ATG16L1 UBE2T HSPB1 SCYL1 CDK12 EBNA1BP2 PCBD1 UHRF1 SHKBP1 GAS5 RNF123 MCM7 HMGA1 RASGEF1A XPO5 TNRC18 CLDN7 EFTUD2 AATF CDC25B EPPK1 MCM2 FEN1 SAC3D1 KRT18 ENO1 BIRC5 NMU CDCA5 RPL8 OVOL1 NME1 WRNIP1 KIF18B MCM10 C12orf66 MCM4 NOP56 TPX2 MARVELD3 FOXM1 RBM42 BOK CDC34 RBM19 PTTG1 CDC20 ATP11A CCNB1 DHX8 SFXN4 ISG15 CEP55 SLC52A2 MKI67 BYSL THOC3 SLC39A4 LRP8 BUB1 SEMA4B TIMM13 POP7 APEX2 TMEM45B ILDR1 KIF20A LAPTM4B GINS4 MRTO4 POP1 RRM2 KIF15 NEK2 TBCB C8orf33 ZNF511 ATAD2 AURKA PMS2P5 ZWINT MRPS16 NCAPG2 RUVBL2 PRMT1 TOP2A MACC1 ANLN FIGNL1 CENPM PRELID1 CENPF SMC4 KIF4A KIF14 CDC6 PFKP F12 SPIDR NUF2 MELK HMMR PTMA JUP PUS7 PFDN4 AGO2 RP9 PSMA7 FANCD2 PRR11 NDC80 ASPM DHFR CENPA GDF15 NUP93 ARHGAP8 DCAF13 MRPS28 MRPS17 ABHD12 SKA3 NCBP2 RPS21 GTPBP4 MCM5 EZH2 TRIM47 RPN1 CCNA2 CKAP2 ZNF367 PRC1 DSCC1 CCNE1 GINS1 CDH3 CDCA2 HSPA8 NUP62CL SPDL1 CDKN3 GTSE1 ADORA2B MAD2L1 SPP1 NUP155 DLGAP5 BRIP1 PRPF4 S100A6 RUNX1 CHI3L1 CDK1 BUB1B CSPG5 TTK CENPH BRCA1 KIF26B TIMM17A NUSAP1 MUC3A IFI6 RACGAP1 down
## MARTENS_TRETINOIN_RESPONSE_DN 0.0018657 0.0137182 -0.5068624 -2.880412 0 722 FLAD1 PSMG3 RECQL4 GPATCH4 TLCD1 YDJC ZNF512B NPM3 HMBS COASY MRPL4 TELO2 MRPS34 NECAB3 TIGD5 MFSD3 PUSL1 TBRG4 APEH HDGF MRPL12 CORO1B FBXL18 C8orf82 HSPA5 FADD TXNDC17 MGST1 VPS9D1 CSNK1D ANKRD13D SYNGR2 METTL1 ZBTB45 SLC2A4RG TYSND1 NUDT16L1 TFAP4 ATXN2L RPS6KB2 LRRC14 WDR6 C19orf48 SOX12 FARSA COMTD1 MYBBP1A MTX1 OXLD1 ZNF598 FKBP2 DDX51 CDT1 APRT IMP4 MYL6B FAM136A RRS1 DDX56 E2F1 ZNF646 PNN HSPB1 PKMYT1 CABLES2 PUS1 CCT5 AK2 NME1-NME2 TBCC RHBDD3 DCXR ATG4D SCNM1 SRM PTGES2 ZNF628 CBX3 TRIB3 TMEM208 SCO2 LDHB ABHD1 TM7SF2 CARNS1 NT5C ROMO1 HMGA1 HSP90AB1 TUFM EME2 TRIM41 ERAL1 MRPS7 AIMP2 RPL37 ZNF785 CNPY2 ZNF513 PTOV1 CHRNG HSPD1 CDK16 MANEAL CALR CCT6A KEAP1 SLC35B2 ACADVL PGLS SOX4 PABPC1 MAGEF1 BABAM1 DDN NDUFA11 BIRC5 UMPS SSNA1 SNHG11 POLD2 SIGMAR1 MRPL2 SNRPE HPS6 PABPN1 HDAC10 GLS2 SNHG12 NLE1 NME3 PAICS TRIM28 GRWD1 DRAP1 MYL5 TMEM129 UTP3 NT5DC2 MAZ MXD3 NOP56 RPS10 SYCE2 SPHK2 WFIKKN1 TRIM65 PHF23 FBXW9 RAD23A NONO MRPL11 ARFRP1 DNASE1L2 PLK1 HNRNPA1 IRF2BP1 CYB561D2 POLR1C THTPA MALSU1 RPL13AP20 BAX CREB3L4 GGCT SMARCC1 KAZALD1 CHMP4A GNL3 TROAP IMPDH2 ZCCHC3 NTN3 TIMM13 CYP27B1 METRN ZNF79 CHMP2A FAM89B POP7 MBD3 CHCHD2 SLC29A2 TUBA1C PA2G4 C10orf95 POLR2L EIF3G SETD6 PPIA IRX3 TMUB2 PSME3 PRRG2 ZNF276 RRM2 TSPAN31 NOLC1 ABHD14A PRR22 C20orf197 PTPRCAP DNAAF2 C8orf33 GPR152 TMEM179B AURKA RPL7L1 RPL37A ARVCF HNRNPU REC8 ZNF629 MRPS16 ZBTB48 C1orf43 PRMT1 EIF5A SPRYD4 CENPM CERS2 CACYBP THAP7 NDUFB10 RPL36 DDX49 ELL3 TSR1 RPS16 DHPS ENDOG ERP29 COPS6 PGP PTMA RPL11 MGAT2 HAGHL TMEM186 ZNHIT2 C6orf62 HNRNPM HCFC1R1 BRICD5 RPL27 RPL19 MC1R TAF7 RPL30 SNRNP35 RPS24 NAP1L4 TMEM102 MAML1 MRPL51 PCIF1 MSH5 MYO1G IL17RE RNF167 RPS6 HPDL CCNA2 ZNF324 GPS2 RPL31 ITPKA AOC2 ZSCAN32 VWA5B2 HNRNPL BLOC1S3 HSPA8 ZBTB3 RFC4 ZFAS1 NXT1 RPS27 RFWD3 CA14 RPL35 CCT4 SPATA25 MIF4GD SLC1A5 FRAT2 MCM3 COX4I1 NANOS1 RSL1D1 PLD6 SLIRP MAD2L1 GEMIN4 HOXD13 MARCKSL1 HNRNPA0 DARS2 ZNF281 CD3EAP SMIM4 LRRC41 MORN1 RPL14 METTL18 STOML2 GP1BA RPL7 MICAL1 PROCA1 ATF5 NUDT19 ARL6IP4 STMN1 COX17 RAB26 CDK1 C6orf132 ACD RRP7A COX7C TIMM8B DDIT3 UQCRQ RPL21P28 TIMM10 SNAPIN HNRNPF FGFBP3 PTP4A1 MOCS3 PAQR4 SRSF6 CIRBP RPL26 KLHDC9 MAPK7 XBP1 HNRNPA2B1 MEPCE RNH1 PPCS MCM6 FTH1 PRSS53 EEF1A1P9 RPS3 CXorf65 IQCC GFI1 RPL10A PNPLA2 ZNF669 TNFRSF13C RPL3 PRDX5 SLFN13 DBP HOXC11 METTL23 down
## NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON 0.0020576 0.0137182 -0.6044516 -2.857338 0 133 RHPN1 ZNF696 EEF1D RECQL4 ZFP41 OPLAH GLI4 TOP1MT TONSL SHARPIN ZNF623 CYHR1 KIFC2 ZC3H3 TIGD5 TSNARE1 MFSD3 TRAPPC9 C8orf82 PPP1R16A CYC1 TSTA3 MROH1 LRRC14 GSDMD KCNQ3 COMMD5 PTP4A3 ZNF7 ZNF517 THEM6 TRMT12 SLC45A4 FAM83A EPPK1 VPS28 RPL8 LY6E GPT MAF1 SLC52A2 ARHGAP39 SLC39A4 C8orf33 ATAD2 NDUFB9 ADCK5 ZNF16 FOXH1 SNTB1 SYBU ZNF251 C8orf31 WDYHV1 PUF60 AGO2 DEPTOR PTK2 MAL2 MAFA FBXL6 SLURP1 DSCC1 KCNV1 BOP1 MTBP CPSF1 EIF3H down
## KANG_DOXORUBICIN_RESISTANCE_UP 0.0020284 0.0137182 -0.7165013 -2.828639 0 51 TK1 DTYMK HJURP ASF1B CDCA8 BIRC5 MCM4 TPX2 FOXM1 CDC20 NQO1 PLK1 MKI67 BUB1 RRM2 ATAD2 AURKA ZWINT NCAPG2 LMNB1 TOP2A CENPM KIF4A POLQ CDC6 HMMR ASPM CENPA HMGB2 PRC1 DSCC1 GINS1 RFC4 CDKN3 MAD2L1 CDK1 BUB1B ABCC1 PLK4 NUSAP1 down
## CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 0.0018762 0.0137182 -0.5201245 -2.825324 0 406 RHPN1 FLAD1 EFNA4 CRABP2 UBQLN4 CYHR1 ZBTB7B ISG20L2 TMEM134 KIFC2 SYT7 SYNE4 NR2F6 HOOK2 BSPRY PGAP3 SMPDL3B PIP4K2C RAB25 PPP1R16A SYNGR2 ERBB2 TMPRSS13 TNK2 RABEP2 CAMSAP3 SPINT1 ABCA12 PKP3 PPDPF ELMO3 RAB40C DSCAM-AS1 TRAF4 LMTK3 TMEM79 PWWP2B SSH3 CYB561 TSTD1 CACNB3 RMND5B EPHA1 LSR JTB ZBTB42 ROGDI SYMPK NOL3 SLC16A14 GOLT1A EPCAM CGN TRIB3 SIGIRR SUOX ST14 AP1M2 TM7SF2 CLDN7 C11orf80 TBC1D30 ZNF74 RAB3D S100A14 EPPK1 SPINT2 IRX5 ENSA F11R TRAPPC6A PROM2 TMED3 SH2D3A KIAA1522 TMEM184A ARRDC1 HIP1R OVOL1 PATZ1 EPN3 NME3 PRKD2 MRPL41 SYTL1 MARVELD3 CBLC SPDEF JMJD8 LLGL2 ZNF467 SPATA2L IDH2 RAB11FIP4 CNNM4 HID1 CREB3L4 GGCT GRB7 LAD1 GRHL2 GRHL1 CHMP2A ULK1 SLC29A2 MUC1 TMEM45B DHRS13 TUFT1 SETD6 ESRP2 MREG RAB17 IQCE FAAH PRSS8 FAM110A TNKS1BP1 ERBB3 DLG3 FKBP4 C1orf43 CDH1 MACC1 ESRP1 MCCC2 P4HTM ZNF165 MPP7 CCDC97 ELL3 TLE3 MLPH RUSC1 TMEM41A GRAMD4 STARD10 ANXA9 ERP29 BLVRB RBM47 MAP7 JUP CSAD ARHGEF5 PPP1R3D CDC42SE1 ZXDC DCAF11 RHBDF1 BCR ARHGAP8 ARFIP2 PLXNA3 PLXNB1 FOXA1 PLCH1 MGMT MKNK2 MAL2 CCDC6 PRR15L PAGR1 TJP3 PCK2 MUCL1 CDH3 SFI1 TMEM191A CHMP4C TMEM183A FRAT2 TTC9 PGAP2 INPP5J ARFGAP2 MEGF9 ALDH3B2 RHOB CA12 ICA1 C6orf132 ANKRD22 ADCY6 SUCO INHBB SCAMP2 MYH14 OVOL2 VRK3 GALNT6 PAQR4 CAPN8 CIRBP SLC37A1 MARVELD2 CXorf40A EPHB3 PPCS ACVR1B SERF2 TMEM125 MYO6 CRNDE SORL1 DBP USP18 SLC52A3 GPR160 TMEM241 TP53TG1 PPM1H PEX11B CEACAM6 RASEF SCYL3 down
## RHODES_CANCER_META_SIGNATURE 0.0020202 0.0137182 -0.6947387 -2.820870 0 59 TSTA3 SMARCA4 PSME2 TRAF4 CCT5 CBX3 PAFAH1B3 AHCY HSPD1 SOX4 E2F5 SNRPE NME1 PSMC4 MRPS12 PAICS ILF2 TPX2 UBE2S NONO PLK1 DVL3 HSP90B1 PRDX4 EIF4A3 TOP2A PTMA NCBP2 MRPL3 RFC4 SNRPF CCT4 CDKN3 MCM3 CANX CDK1 COPB2 SDHC ACLY HNRNPA2B1 down
## SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 0.0018248 0.0137182 -0.5126959 -2.812396 0 444 DUS1L RECQL4 TMC6 HMBS ZNF212 SNRNP200 NDUFS8 PARP1 NDUFS6 TAF6 SUPT5H RRP1 PSMD4 CDK2AP2 B4GALT7 DVL1 SMARCA4 SOX12 FARSA UBE2C NME4 PPAN FKBP2 ENO3 SART1 APRT MYL6B PSME2 GSS DECR2 HSPB1 LSM4 SLC12A9 GOLGA2 NARF GPX4 BCAT2 B3GAT3 IL27RA DCXR DEAF1 SPG7 CDK5 CD2BP2 STXBP2 AUP1 RALY RGS14 POLRMT MAD1L1 NUDT1 ARID3A SCLY AHCY TACC3 TP53 RPL37 PMF1 KIF22 MAP2K2 COPG1 ENSA PABPC3 TOMM40 PEX6 SGPL1 PGLS DROSHA ACOT8 GFER DAZAP1 BRD8 XRCC2 NENF CCNF CNPY3 LDB1 GIPC1 GRK6 PRDX2 IMPDH1 COX6C PIAS4 BANF1 FDXR NONO PTTG1 CDC20 ACY1 DNASE1L2 HNRNPA1 APBA3 PQBP1 CNPPD1 HAGH MEF2D TCIRG1 POLE BAX KHSRP MLF2 STAT2 CSNK1G2 SFN TGIF2 SCAND1 SF3A2 CTTN XRCC1 TROAP SGTA PSMB5 NDUFB7 WRAP73 ZP3 MBD3 PSMD13 APEX2 GTF3C1 NDUFS5 KIF20A PSMB3 RREB1 UCP2 FDPS AURKA C1QBP RPL37A ARF1 HNRNPU CSK DPAGT1 TRA2A FANCA TOP2A DHCR7 GBA HTT MRPL23 B4GALT2 CACYBP CENPF RPL36 IL21R NDUFA1 CDK11B COX6B1 AKR1A1 PTPN7 PTMA POLR2I CHMP1A ICAM3 MEA1 PIN1 RPL19 AP1B1 NDC80 SPAG5 FKBP3 PKN1 TESK1 DPM3 DPF2 HSPA9 TARBP1 MPST SMARCD2 TECR TTF2 RAB1B MSH5 CRCP TEX264 POLG EZH2 ZNF544 GALE CSNK1E RPN1 RPL27A PCK2 RPLP2 HNRNPL NDUFA7 SAFB IVD KAT5 PAIP1 ARF5 PGAP2 COX4I1 TBCA MBOAT7 MARCKSL1 CD70 UQCRC1 MZF1 TCOF1 SERTAD3 GNL2 RRP7A UQCRQ VPS4A ACTL6A KCNK1 PTP4A1 CD19 NET1 RPS7 HNRNPA2B1 PFN1 PARK7 PEX14 PSMC3IP COX5B CD74 SNRPD1 HHLA3 NAGLU RGS20 YARS2 SERF2 NUTF2 down
## DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 0.0019724 0.0137182 -0.5371988 -2.811895 0 305 RECQL4 TONSL NOS1AP CEP85 TK1 GREB1 CHTF18 PCP4 CIT SNRNP25 MYBL2 TIMELESS EXOSC5 TFAP4 NR2C2AP UBE2C GLB1L2 CDT1 WDR34 SFXN2 POLD1 UBE2T E2F1 WDR62 LSM4 PKMYT1 IQGAP3 UHRF1 RNASEH2A MCM7 AREG TMEM120B ASF1B NUP107 TACC3 CHAF1A CHRNA5 TRAIP AURKB MANEAL MCM2 FEN1 EXOSC2 DNMT1 INCENP BIRC5 XRCC2 CDCA5 POLD2 FANCG NME1 MCM10 MCM4 CHAF1B E2F2 TPX2 FOXM1 SPC24 LIG1 PTTG1 PLK1 MIS18A POLE DHTKD1 CEP55 MKI67 KIF2C TROAP BUB1 CENPL RRM2 ESPL1 ATAD2 AURKA CD320 ZWINT FKBP4 NCAPG2 EXO1 LMNB1 CLSPN FANCA TOP2A PPIF ANLN FIGNL1 CENPM KIF4A POLQ CDC6 SLC7A5 NCAPH2 HAUS4 NUP85 CNIH2 MELK RAD54L XYLB NCAPH FANCD2 PRR11 SPAG5 ASPM NCAPD2 CENPJ CENPO NCAPD3 TFDP1 L2HGDH SIAH2 TTF2 SKA3 DSN1 MYO19 DEPTOR MCM5 FAM111B KCNK5 SHCBP1 CCNA2 KRT13 ZNF367 PRC1 DSCC1 GINS1 DNA2 CDCA2 RFC4 EPS15L1 KIF11 CELSR2 SPDL1 MCM3 GTSE1 IMPA2 DARS2 MCM8 DLGAP5 HELLS KNTC1 BRIP1 SLC22A5 CA12 STMN1 CDK1 BUB1B CCNE2 CDCA7L TTK PLK4 C1QTNF6 PAQR4 TICRR BRCA1 XBP1 NUSAP1 RACGAP1 PSMC3IP MCM6 MAP6D1 KNSTRN GMNN TST CDC45 TMEM241 STIL ARHGAP11A JPH1 CENPI RMI1 WDHD1 CENPN down
fgsea_plot(fgsea_res$res_c3, pathways_title='C3 regulatory target genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## EPC1_TARGET_GENES 0.0020619 0.0047852 -0.5394669 -2.844877 0 332 RNF44 SLC4A2 TRMT2A MRPL4 ALG3 INTS1 FBXO41 CCDC57 CRELD2 REPIN1 ZGPAT ZBTB45 ECE2 CAD RANBP1 WDR5 PDAP1 NCL ATG4B LARP1 SETD1A LSM14B DDX51 NOC4L NELFCD DECR2 ESRRA ZNHIT1 DHX37 PUS1 NME1-NME2 POLR2J THAP4 SCNM1 CLUH SNHG7 TSFM MST1P2 LDHB MCM7 HMGA1 CCDC169 AIMP2 DNPH1 U2AF2 RABGGTA MCM3AP-AS1 TMEM63B AURKB HRAS CROCCP2 MTG1 MALAT1 SSU72 PABPC1 VMAC AP4M1 GFER NDUFA11 CCT2 NME1 GRK6 RNPS1 ADRM1 C12orf66 MRPL14 MAZ NOP56 POFUT2 UBE2S BANF1 GUSB CCDC86 ARHGDIA ARFRP1 G6PC3 VEGFA CNOT11 HNRNPUL1 HAGH SFXN4 ISG15 DDX42 BYSL DUS3L PTBP1 LYSMD1 MMP15 TIMM13 ZP3 TXNL4A CAMTA2 ZNF839 PLOD3 ZNF581 CCDC106 CD63 KLF16 KPNB1 ANP32B ZNF580 LRRC59 MED20 GSE1 URB2 PRMT1 SCAP GBA DIAPH1 EIF5A SPRYD4 PKM IZUMO4 TRPC4AP F12 MRPL15 NUF2 ZNF775 TBL1X PTMA PPAT EIF1AD SLBP RNF145 PMS2 SNRNP35 NCBP2 RAD23B MOB3A EZH2 HES4 GALE SLC3A2 XPOT RALGDS HEXIM2 NFKB2 ANP32A GOT2 MRPL3 GNAS-AS1 FAHD1 B3GALNT2 COA6 CCT4 CCDC47 COX4I1 MRPS35 PLD6 SCAMP5 ASNS METAP1D ADNP PDXK DUS2 ALG12 SURF4 BUD31 HNRNPF MVK EMC8 RPL26 ZNF587B down
## FXR1_TARGET_GENES 0.0019268 0.0047852 -0.4844012 -2.811787 0 1002 EFNA4 ZNF696 ASB16 PYGO2 RECQL4 JMJD4 SNAP47 INPPL1 WDR4 NPLOC4 SHARPIN ZNF692 SLC50A1 HMBS ZNF623 CYHR1 C1orf61 SYT7 ZC3H3 USF1 SLC25A22 ATXN7L3 NECAB3 CHMP6 AARS2 RPTOR OGFOD3 HOOK2 MFSD3 PUSL1 FBRS TRAPPC9 B4GALT7 MRPL12 CORO1B GMEB2 SEC24C DPH7 SNRNP25 XYLT2 ZGPAT CAPN15 ANKRD13D ZBTB45 WDR55 SRCAP CYC1 MRPL28 PFDN2 TYSND1 IRF7 ATXN2L CUL9 FTSJ3 LRRC14 SIPA1L3 ERCC2 RHOT2 TSEN54 SRRT PDAP1 UBE2C DNAJA3 FAM50A RTN4RL2 KCTD5 CHD8 MTX1 RNF40 KRTCAP3 LSM14B RCC1 NELFA MRPL21 KCNC3 MRPL38 KMT2D ELMO3 FKBP2 TSR3 FBXW5 SART1 DNMT3A CAPN12 PNKP NOP9 POLD1 DDX56 ZNF213 TSTD1 TACO1 MFSD9 PKMYT1 UBTF HAX1 LSR EML2 ZBTB42 DEAF1 ABCA7 SYMPK NOL3 TRABD SRM NAB2 CRTC2 RNU5A-1 PPP1R37 MNT PHPT1 TALDO1 SIGIRR TSFM NADSYN1 RNASEH2A PPIL2 ARFGAP1 ABHD1 CSRNP2 PRDM15 MAD1L1 PIGO NOP2 EHMT1 NMT1 HJURP ATAD3B SLC35B1 CLDN7 POLR3K SRRM5 DPM2 NOM1 PPP6R1 MSLNL STUB1 MSTO2P PMF1 F11R PLEKHA8 ANKZF1 ZNF513 PTOV1 ATP2A1 PSMC5 PRR7 CALR SLC25A15 ANAPC2 PIGQ UNC119 GSK3A CMTR1 SLC35B2 SAC3D1 MFSD10 ACADVL NOL12 TAF4 DRG2 KIAA1522 C8G PPP4C SNORA14B IGHMBP2 ENTPD6 METTL2B TMEM147 C16orf91 CCNF SSNA1 ZNF764 SNRPE RRP36 PTDSS2 AMH ALDOA SPAG4 DBNL IRGQ CDYL HSD11B1L TSPAN10 MVP APEX1 TRIP6 GNPTG DDX55 ZNF579 GTF3C5 CRELD1 TOP3B GRWD1 ATG9A MAZ MXD3 USP19 IMPDH1 SYCE2 ZMAT2 RBM28 CIC SYTL1 TRIM65 FBXW9 FOXM1 RBM42 TRMT61A MRPL11 PCYT2 ARHGDIA HNRNPAB ZNF653 ARFRP1 PLK1 CTNS MIS18A SLC35E3 ZC3H4 ACIN1 MRPS26 HAGH ABCB9 RABIF TCIRG1 PHF12 MAF1 DDRGK1 IL17RC CASP6 CREB3L4 CYTH2 MAP3K11 PIGM KAZALD1 ZSWIM8 OSGIN1 ARID1A PPFIA3 SUMF2 WDR83 AIFM1 HMGB3P22 ALG1 FEM1A PSMB4 POLR2A LTBP3 SEC13 GRHL1 TIMM13 METRN B3GNT8 CHMP2A ZNF768 TNPO2 AMDHD2 BCRP8 GGN MUC1 EPN1 C1orf109 PA2G4 DHRS13 RER1 MORC2-AS1 ZNF839 EIF3G AVIL LRIG3 FAM193B STRN4 PACS2 THBS3 INO80E PRR7-AS1 ZFAND2B C9orf163 FRS3 TMEM201 SMG8 RREB1 CCND1 FAAH SHPK NOLC1 ARX NDUFV3 FRMD5 C8orf33 SIPA1 ZNF3 TRMT112 TMEM179B PEX10 C1QBP RAE1 PMM1 EXOSC6 SNRPC UNC45A DNAJC11 DHCR7 CTSA GBA AGK POMT2 CHCHD1 B4GALT2 TOR4A SMURF1 CASP2 DHRS1 HDDC3 MPV17 BSCL2 EPHX1 TPRN SEZ6L2 RPL36 SUSD4 CDC6 ELL3 ASPHD1 GPI MLPH AAR2 COMT DHPS PTOV1-AS1 NUP85 CNIH2 RPUSD4 MPI NUF2 DMAP1 SS18L1 CXorf56 IKBKE LENEP MIRLET7I POMZP3 CORO2A PCED1A GSTZ1 FAM131A SLBP NAGPA KPTN IARS2 PSMA7 LARS2 ZNF77 MAMSTR CENPA WDR81 VPS16 LZTR1 SMARCD2 ACOX2 NUMA1 PAM LIN37 CWC25 GLCCI1 PADI1 PPP1R13L PLXNB1 RHOF RPL36AL GTPBP4 PAQR6 RPS6 BGLAP MRPL44 DTD1 PHLDB3 MED29 UCK1 TRIM47 ZNF544 SAE1 POM121C PLCH1 TBC1D10A CCNA2 GPS2 CYP2D6 NUP210L SIX5 FKRP RALGDS TJP3 MRI1 PCK2 HNRNPL HMCES MRPL3 CLK3 ZFAS1 UNC93B1 SH3GL1 FAHD1 TMEM182 HIRA POLR2J4 HYI PAIP1 SLC1A5 SNX19 ACOX3 AP2A2 CPSF1 STX6 PIP4K2B GTSE1 MIR4512 GEMIN4 MRPL10 RPL13 OGFOD2 CANX MORN1 HUWE1 AMN SH3D21 DPCD TAOK2 ZSCAN16 PSTPIP1 down
## SUPT20H_TARGET_GENES 0.0018692 0.0047852 -0.4748090 -2.787481 0 1169 FLAD1 EEF1D RECQL4 JMJD4 SNAP47 SMPD4 WDR4 SHARPIN CLPTM1L RCE1 MIR4479 TRAF2 ABCB8 TRMT2A NPM3 COASY MRPL4 ISG20L2 ZNF687 GTPBP3 ZC3H3 MRPL24 ABCF2 MZT2B TIGD5 RPTOR PDCD6 C7orf50 FAM207A NUBP2 B4GALT7 TRMT1 HDGF MTND5P11 TBL3 FBXL19 ADAR PRCC LONP1 HSPA5 VPS9D1 TRUB2 TARS2 PRPF6 ZBTB45 RFXANK CEP250 CDK5RAP1 MRPL28 EXOSC5 RANBP1 RPS6KB2 LRRC14 GCDH ABCF3 MYPOP EMC10 BECN1 GTPBP2 DNAJA3 KCTD5 NDOR1 TCF3 RECQL5 PTPN23 NSUN2 MRPL21 TMEM101 NVL KMT2D RAB40C TSR3 SLC39A3 DDX51 STIP1 NOC4L RRNAD1 BMS1 GOLGA3 TBC1D10B DDX56 LMAN2 MLST8 NOP14 LGALS3BP MRPL55 LSM7 ZNF646 TACO1 ZNHIT1 ACAD9 EIF2B4 AARSD1 YIPF2 HAX1 AK2 NME1-NME2 RHBDD3 CDK12 SCNM1 SPG7 TRIM46 AP5Z1 E2F4 DDX41 CRTC2 FBXL19-AS1 CTU2 CXXC1 TMEM208 LRCH4 TSFM MST1P2 MPHOSPH10 NAT10 EHMT1 ARID3A NMT1 AURKAIP1 ATAD3B SLC35B1 NUP107 WDR53 RUVBL1 EFTUD2 SRRM5 ISOC2 ERAL1 PPP6R1 RAB3D UBE2I RPL37 KRTCAP2 MRPL20 DDX23 DPP9 TMEM9 FAM71E1 ENSA TRAPPC6A SLC4A1AP PREB CNPY2 LRSAM1 EEFSEC HSPD1 CCDC142 MRPS23 CROCCP2 MRPL9 TOMM40 ANAPC2 CACTIN ZC3HC1 NOL12 FOXRED1 OAZ3 SSU72 DRG2 ACOT8 CDCA8 IGHMBP2 ARMC6 XRCC2 CHMP4B WDR24 C16orf91 SSNA1 MRPL2 DHDDS RNU5E-1 IRGQ NME1 NFKBIB SCFD2 PSMC4 ILF3 PABPN1 GNPTG TUT1 DDX55 GTF3C5 MED24 TOP3B UTP3 CCDC12 USP19 POLR3E PTCD1 ILF2 COPE ZMAT2 SPHK2 EVI5L RBM28 SAP30BP CIC BANF1 PIGG FBXW9 RAD23A RBM42 GPAM SPPL2B SPC24 CCDC86 PSMC3 RBM19 GBF1 HNRNPA1 C12orf76 MIS18A CLPB TMEM259 PIGT MED9 HNRNPUL1 CYB561D2 HAGH ABCB9 UNK INTS5 GAR1 CCDC130 LRRC27 STK32C PHF12 MAF1 POLE AKAP8L SLC35E1 PPRC1 KHSRP CYTH2 MAP3K11 PMS2CL DDX42 FAM220A BYSL HSP90B1 CHMP4A TMEM222 PRMT5 RAD9A ZSWIM3 DYRK1B COPS7B NOSIP WDR83 HMGB3P22 ALG1 SP2 FEM1A ANKRD11 LYSMD1 POLR2A XAB2 SEC13 CCDC159 RPIA PET100 SLC27A5 ZNF79 IPO4 RAB11B MT-ND1 C1orf109 LAS1L ZKSCAN4 CENPL MAFK MAP2K7 PLOD3 ANKRD16 ADPRHL1 PSME3 ZNF581 NAIF1 MRTO4 RFX1 RPUSD2 CCDC106 DCAF15 SMG8 INO80B PRRG2 ZNF276 FAM222B RNU5B-1 TSPAN31 KIF15 MAD2L1BP TMEM63C FDPS NDUFV3 KCTD2 FRMD5 C8orf33 RPL12 DHX38 PDRG1 ZNF580 RPL7L1 SPSB3 NPRL2 CHRNB1 MED20 DCAKD SNRPC DNAJB12 GATAD2A UNC45A DNAJC11 PRMT1 TRMT44 PWWP2A SLC35A4 TPCN1 PAK1IP1 NDUFAB1 THAP7 SMC4 AGBL5 ZNF165 DCTN5 ACSF3 FAM117A RPL36 DDX49 CCDC97 AHSA1 GPI AAR2 NCAPH2 TMEM160 PRMT7 TMEM41A NUF2 DMAP1 BCKDHA STX4 MCRS1 GTF3A PUF60 RTEL1 LMF2 VCP DNAJB11 NF2 JUP BMF SIVA1 TMEM203 EIF1AD MED18 MTOR ZNF668 NAGPA AAAS BAP1 SAYSD1 DAGLB DNAJC21 FANCD2 VPS51 TTC31 RBBP5 ZNF77 YEATS4 TMEM141 NFATC2IP NDC80 TSKU C1orf74 MRS2 RELA TTC1 C12orf43 RNF121 DPF2 DCAF11 CENPA SUPT7L DDX19A WDR74 CWC25 MRPS17 MPV17L2 SLC7A6OS USP42 SKA3 NCBP2 SYNGR4 PPP1R13L CHTOP SNAI3-AS1 RNF167 GTPBP4 CIAPIN1 POLG RPS6 PPP2R1A MRPL44 DNAJC2 PROSER1 POM121C NBR2 KATNB1 CCNA2 UBXN6 COQ4 RPL31 ITGAE SMG7-AS1 AP2A1 HEXIM2 SLC25A42 PAGR1 RPLP2 NDUFS3 HNRNPL BLOC1S3 VTI1A UQCC1 ZNF408 GPATCH3 NDUFA7 RPRD2 SAFB MRPL3 ZBTB3 MTHFSD SLC2A11 PXMP2 MT-TP VPS25 ZFAS1 ZNF263 ZBTB17 TMEM205 MTBP CCDC58 FAHD1 SUGP2 HIRA CCT4 PRPF31 NGDN CCDC47 TMEM183A COQ9 PDE4A ACOX3 VIPAS39 ENPP3 CPSF1 APBB3 HNRNPA0 EMC1 AHCYL2 DARS2 ADPRHL2 OGFOD2 ACP2 TPI1P2 NUP155 NOL8 CANX CD3EAP NDUFS7 SMG7 FARS2 STOML2 FBXO24 TRUB1 FBXO45 COPS5 NUDT18 GPR108 DUS2 SPAG7 CWF19L1 CKLF-CMTM1 QRICH1 ACO2 SFSWAP COPB2 NUP214 BUB1B RTEL1-TNFRSF6B U2AF1L4 PSMF1 RN7SL1 TSSC4 KLC4 BRIX1 POMGNT1 PSMB7 DCTPP1 NR1H2 MVK CTNNA1 TYW5 TUBD1 NUDT5 MOCS3 TICRR BANP NFIC BRCA1 down
## KLF14_TARGET_GENES 0.0020202 0.0047852 -0.5453055 -2.753949 0 215 JMJD4 SNAP47 ANO8 MRPL4 KCTD13 NAT9 SYT7 GTPBP3 CDK5RAP3 CCDC57 FAM207A VPS9D1 RFXANK UBE2Q1 EARS2 KCTD5 TCF3 UBFD1 KMT2D SLC39A3 NOXA1 CATSPERG HAX1 TLE6 SNHG7 EDC4 GAS5 MNT AURKAIP1 SIRT6 CDK4 MAP2K2 PTOV1 HSPD1 ZNF205 MEGF8 UCKL1 ADAM15 TMEM104 DRG2 MARK4 MRPS15 NLE1 EN2 TOP3B PTCD1 RBM28 BANF1 ATP4A TBC1D13 HMG20B TAGLN2 POLE ARID1A KCNN1 NOSIP YIF1B SEC13 ZNF839 ZNF581 SMG8 INO80B PRRG2 ZNF276 FAAH BRPF1 AGK FCHO1 CNDP2 PKM GEMIN7 PTOV1-AS1 FAM83E DMAP1 PUF60 RTEL1 EIF1AD ZER1 FAM131A VPS51 C1orf74 SMARCD2 PCIF1 PISD RASA4CP MRPL44 SMG7-AS1 EXD3 TJP3 CCNE1 NDUFS3 ZNF408 PXMP2 MFSD12 LINC00431 ENPP3 CPSF1 ACP2 TPI1P2 NDUFS7 SMG7 SNORA13 LMX1B RTEL1-TNFRSF6B EGLN2 KCNIP2 NR1H2 PLCH2 RPS7 PI4KA down
## CEBPZ_TARGET_GENES 0.0019011 0.0047852 -0.4541592 -2.678866 0 1304 RHPN1 FLAD1 ZFP41 CCDC137 NPLOC4 SHARPIN MIR4479 NOL6 TRAF2 ABCB8 CEP85 TDRKH DPP3 CYHR1 MRPL4 BRPF3 ASB16-AS1 NDUFS8 ISG20L2 TMEM134 P4HB ZNF687 GTPBP3 FOXK2 PDCD11 RPTOR LRRC45 OGFOD3 ARHGEF19 CDK5RAP3 C7orf50 FAM207A SNAPC4 CDK2AP2 FBRS MAST1 NUBP2 B4GALT7 PYCR2 TRMT1 HDGF TBL3 DPH7 CIT SNRNP25 HSPA5 AP3D1 TARS2 SDF2L1 CDK5RAP1 HGS MRPL28 MROH1 DGCR8 WDR6 ERCC2 MORC2 EARS2 PDAP1 UBE2C ATG4B PNKD PSMD3 KCTD5 COMTD1 NDOR1 ANKRD39 CHD8 OS9 RHPN1-AS1 TCF3 MAP3K9 RECQL5 UBFD1 OXLD1 MRPL21 RAB40C TSR3 SLC39A3 MAEA STIP1 FBXW5 BMS1 ZDHHC12 TYK2 PDIA4 GOLGA3 PNKP CCT7 BAZ2A TBC1D10B DDX56 ZNF213 LMAN2 MOSPD3 ATG16L1 MLST8 E2F1 DOLPP1 TACO1 CPSF4 RMI2 YIPF2 NARF AK2 SAMD4B NME1-NME2 EML2 ZNF672 IKZF4 ROGDI THAP4 ABCA7 SPG7 TARBP2 MIR4449 DDX41 CRTC2 SHKBP1 RNFT2 PHPT1 STK11 SLC27A4 LRCH4 DPH2 MST1P2 POLRMT QPCTL ARFGAP1 AAMP RPL38 MPHOSPH10 ARL16 ASF1B NUP107 POLR3K WDR53 RUVBL1 RNF187 FAM98C ISOC2 NOM1 GPR137 AIMP2 RAB3D ZSWIM1 CHAF1A RPL37 KIF22 SNORD60 TMEM9 ENSA TRAPPC6A SLC4A1AP PDIA6 TRAIP ANKZF1 HSPD1 PDXP HRAS MRPS23 TIMM44 CROCCP2 TOMM40 LRRC47 ANAPC2 MIIP ZSCAN31 AKT1S1 ZC3HC1 INCENP VPS28 DROSHA ACOT8 NUDC CDCA8 VMAC C8G BABAM1 IGHMBP2 MGRN1 ENO1 ARMC6 NDUFA11 TECPR1 CCDC51 UMPS CCDC61 WDR24 CCNF TRAF7 CNPY3 SSNA1 POLD2 MRPS15 SNRPA RRBP1 PEX16 NME1 WIZ ORMDL2 POLM VPS72 TSPAN10 GRK6 PABPN1 SNHG12 GNPTG DDX55 GTF3C5 MRPS12 SND1 ADRM1 ZDHHC9 TOP3B ATG9A DRAP1 MYL5 CCDC12 PTCD1 MTMR4 NOB1 COPE ZMAT2 LAMTOR4 EVI5L RBM28 SAP30BP EMC9 CIC GYS1 BANF1 RBM42 GATAD2B JMJD8 SPC24 LLGL1 HNRNPAB PCGF1 GOT1 DNAJC14 GBF1 HNRNPA1 SEMA4F C12orf76 CTNS MIS18A SZT2 HNRNPUL1 MED16 MDM1 HAGH RPUSD3 ZSWIM4 INTS5 EPOR CCDC130 LRRC27 CIZ1 G6PD MAF1 AKAP8L KHSRP CREB3L4 SLC52A2 GGCT CYTH2 MAP3K11 PIGM FAM220A DDA1 RASSF7 ZSWIM3 ARID1A TYW1 ZNF324B COPS7B C19orf53 PAF1 ALG1 PTBP1 SP2 ANKRD11 TROAP POLR2A XAB2 SEC13 CCDC159 RPIA ZNF574 PET100 SGTA IPO4 RAB11B CHCHD2 ZNF691 C1orf109 PPIA GANAB PAAF1 PSMB3 ANKRD23 ANKRD16 TMUB2 COX19 ZNF581 NAIF1 RFX1 ELAC2 DCAF15 PNPO CDC25A SMG8 FAM222B TSPAN31 SHPK MBD1 CS TBCB RGMB-AS1 KCTD2 SDHAF1 FRMD5 C8orf33 OSBPL2 KPNB1 TMEM179B AURKA DHX38 DDX39A SPSB3 ALKBH6 POMT1 ELMO2 ARVCF RPS20 SNRPC GATAD2A YIF1A URB2 MRPS16 C19orf81 HINFP RUVBL2 DNAJC11 PRMT1 TOP2A DHCR7 CCNL2 TRMT44 CTSA PWWP2A RNF4 SPATC1L GBA HTT PPP1R12C TBC1D14 TPCN1 CENPM CKAP2L ZNF165 TPRN DCTN5 RAB3A FAM117A DDX49 POLQ TANGO2 TSR1 TMEM160 COMT CDK11B NABP2 CREB3L2 TMEM41A RAB40B DCAF4 NUF2 RAB4B MLLT1 ZNF775 MAPK8IP3 SLC39A1 PGP RAD54L UBALD2 VCP STK40 TSR2 NF2 JUP POLR2I TMEM53 NPHP4 SIVA1 TMEM203 EIF1AD MTOR NAGPA TMTC4 TRMU PIN1 FANCD2 VPS51 SLC2A8 ZNF77 CHD6 NFATC2IP PRR11 PMS2 ZNF174 SFXN5 SLC35F2 DCAF11 CENPA WDR81 DEF8 WDR45 SUPT7L ITFG2 PSMD11 TRIM68 DPH1 LIN37 HINT2 CHCHD7 CWC25 MPV17L2 GLCCI1 TTF2 MSH5 KDM4B SNAI3-AS1 CDC25C GNA12 SAP30L-AS1 TAF1C MCM5 PPP2R1A FAM111B DDOST SARS2 MRPL44 MED29 HOMEZ RBM14 KATNB1 CCNA2 UBXN6 LMTK2 FBXL6 ITGAE ZNF419 AP2A1 SLC25A42 ZNF367 ZSCAN32 NDUFS3 HNRNPL BLOC1S3 ZNF354A VTI1A CDIPT GPATCH3 MED8 MRPL3 CDCA2 ZBTB3 APMAP NXT1 TMEM205 RFWD3 FAHD1 HIRA IVD RIOK1 DANCR PRPF31 NGDN SLC1A5 PDP2 ZNF101 ZNF837 ACOX3 CDKN3 PGAP2 WDR12 DERL3 MCM3 ENPP3 COA4 SWSAP1 NRL DHODH RNU6-9 FLYWCH2 RPS15 KIAA0895L MRPL37 CANX NDUFS7 MEGF9 SHC1 ZNF584 IRF4 DLGAP5 CTPS1 RTN4R STOML2 GOSR2 FBXO24 LINC01003 IDH1 MZF1 BRIP1 PLIN3 ECSIT FBXO45 GPR108 DUS2 HIBADH SPAG7 CLASP1 CWF19L1 HDAC11 AGFG2 ZSCAN20 GOLPH3L PGD MANBAL ACO2 SFSWAP NUP214 C14orf93 TIMM8B NUDT16 PSMF1 PSMB10 MCAT BUD31 ACTL6A PSMB7 NSMCE1 DCTPP1 NR1H2 MVK SRSF6 CIRBP ERICH1 TICRR RGMB ZNF100 CSTF1 BRCA1 ZNF587B ZNF250 ZNF695 RPS7 ABHD8 TRAFD1 DCBLD2 DCAF7 CLUHP3 SARNP MON1B CEP152 PEX14 SNRPD2 CWC15 PSMC3IP down
## GGAANCGGAANY_UNKNOWN 0.0020121 0.0047852 -0.5866932 -2.652605 0 103 SMUG1 SEC24C PDAP1 FARSA MRPL21 BMS1 ZNF48 EBNA1BP2 CLASRP E2F4 RPL38 U2AF2 ZNF513 MRPS23 PEX6 IGHMBP2 UGGT1 SNRPE DDX55 DLX4 GYS1 BANF1 SZT2 PSMB4 RNF25 SUPT6H CHMP2A EPN1 MBD1 PTPRCAP GGA1 RUVBL2 PGS1 COX6B1 MRPS21 SEC61A1 MRPS18A EIF1AD PCED1A SDF2 STK36 CCDC71 MAP4K1 VPS16 NCBP2 UBXN1 MRPL43 SEC61G MED8 RPL28 EIF3H ZNF384 MTA2 EIF3K BUD31 MOCS3 ZDHHC5 PRKAB1 SRP54 down
## KAT5_TARGET_GENES 0.0019802 0.0047852 -0.4649804 -2.648133 0 768 YDJC SLC4A2 ZNF692 TRMT2A MRPL4 ISG20L2 PYCR1 NAT9 GTPBP3 PARP1 GID8 VPS9D1-AS1 HOOK2 SUPT5H MFSD3 PFAS HDGF MTND5P11 TBL3 PRCC PPM1G ZGPAT VPS9D1 METTL1 SRCAP CAD RANBP1 UBAP2L ATXN2L LRRC14 WDR6 SIPA1L3 ASPSCR1 EARS2 POLR2D BECN1 COMTD1 LARP1 PPDPF MTX1 PPAN UBFD1 SCAF1 ZNF598 NSUN2 NELFA FBXW5 SART1 RRNAD1 APRT BMS1 NELFCD PELP1 DDX56 UBE2T ACAD9 EIF2B4 NCOA5 PUS1 HAX1 NME1-NME2 JTB FPGS ODC1 DCXR CDK5 MST1 ING5 SIL1 CLUH RRP12 SNHG7 RGL4 ZNF239 CBX3 PHPT1 TMEM208 MST1P2 C1orf53 LDHB PRDM15 RNF123 HMGA1 HSP90AB1 FASN GADD45GIP1 GNL3L TACC3 GPR137 TP53 AIMP2 DNPH1 DGCR2 UBE2I RABGGTA MRPL20 ZNF785 DPP9 KDM2A RANGAP1 MED15 MCM3AP-AS1 CHCHD10 AURKB CROCCP2 MCM2 TOMM40 ORMDL3 C1orf122 ZNF202 TMEM104 SLC35B2 MALAT1 MAPK8IP2 PABPC1 MARK4 C8G SNORA14B ZNF444 CCT2 BIRC5 UMPS C16orf91 POLD2 MRPS15 TMED4 PES1 SNRPE NME1 VPS72 PSMC4 HSD11B1L SNHG12 DDX55 NLE1 MRPS12 RNPS1 C12orf66 TMEM129 MXD3 ILF2 RBM28 DIDO1 USP20 UBE2S BANF1 RAD23A MRPL11 ARHGDIA STAG3L5P ARFRP1 PLK1 G6PC3 VEGFA SLC35E3 TRIM52 MEF2D CCNB1 PHF12 TAGLN2 PPRC1 ARPC5L SMARCC1 DDX42 BYSL PRMT5 PPFIA3 POLR2E NOSIP DUS3L HMGB3P22 PTBP1 POLR2A SEC13 ZNF574 TXNL4A PA2G4 DHRS13 HDLBP PLAGL2 ZNF839 EIF3G PPIA MAP2K7 PSME3 THBS3 PRRG2 KLF16 KIF15 NOLC1 DDX31 NDUFV3 C8orf33 KPNB1 ATAD2 ANP32B ZNF3 RPL37A RAE1 MED20 RPS20 PLEKHG2 PIGU DPAGT1 C1orf43 TRA2A PRMT1 DIAPH1 SPRYD4 AGBL5 RPL36 SNF8 PFKP TSR1 GEMIN7 F12 TOP1 DCAF4 NUF2 DMAP1 ACACA AEN C22orf46 TBL1X SRPRB CFL1 MIRLET7I TNIP2 STAT1 PPAT EIF1AD VPS26B PUS7 SLBP MT-ND3 SRD5A1 C6orf62 RCCD1 BAP1 HCFC1R1 ATP6V1E2 RPL27 FANCD2 RNF145 RPL19 CDC42SE1 PMS2 SLC35F2 RPS24 HSPA9 DCAF11 USE1 CORO1A WDR81 LZTR1 DDX19A SOD1 NCAPD3 DPH1 WDR74 NOP58 C2CD2L USP42 MIR4519 CHTOP RAD23B GTPBP4 POLG RPS6 RBM12B SARS2 SFT2D2 WNT10A EZH2 DTD1 SHCBP1 SLC3A2 TXN UBXN6 FAM86KP XPOT CHFR HEXIM2 ARF6 RPLP2 CCNE1 PPIH MRPL3 GIT1 NXT1 SNRPF RIOK1 PRPF31 CCDC47 AP2A2 GNB2 SNHG6 RSL1D1 MRPS35 NRL PLD6 MIR4512 UFC1 RPL13 CHD2 RPS15 CANX NDUFS7 LRRC41 ASNS TMEM185B PRMT2 KNTC1 ADNP SERTAD3 SLC19A1 COX17 SPAG7 CDK1 SENP2 COPB2 TIMM8B RN7SL1 TIMM10 DIP2A HNRNPF TAF12 ERICH1 LTV1 CNN2 BRCA1 ZNF587B HNRNPA2B1 USP4 RBM33 GABPB1-AS1 CLTC SF1 UQCRH POFUT1 AMPD2 MT-CO3 SDHAF2 RPL10A MAST4-AS1 TM9SF1 FNTB BRD2 CENPT BBS1 DBP NACA TRMT61B SNRPB RAD51D CPSF7 RPSA AGBL5-AS1 CTDP1 RPS29 MRPL53 MAP3K14 EID2 RMI1 SNX17 YTHDF3-AS1 MGME1 GLO1 DHX9 SNHG1 PPP1R10 down
## THAP1_TARGET_GENES 0.0019084 0.0047852 -0.4383655 -2.625186 0 1667 RHPN1 DUS1L TSPAN17 PYGO2 PABPC1L ANAPC11 JMJD4 SNAP47 CCDC137 C1orf35 SMPD4 TOP1MT SAMD10 NPLOC4 SHARPIN CLPTM1L MIR4479 TRAF2 TRMT2A RPUSD1 COASY MZT2A MTG2 MRPL4 ZNF212 B4GALT3 NCLN ISG20L2 IWS1 P4HB ABCC10 GTPBP3 USF1 MRPS34 NDUFS6 MZT2B AARS2 GID8 RPTOR SMG5 CHTF18 HOOK2 NMRAL1 C7orf50 TBRG4 CCDC57 CRELD2 FBRS NUBP2 B4GALT7 PYCR2 SH3BP5L DDX27 TBL3 FAM86C1 DPH7 POLR1A USP21 LONP1 GON4L GTF3C2 FADD ZGPAT VPS9D1 QTRT1 TRUB2 PRPF6 YTHDF1 ZBTB45 ALYREF EIF4G1 RFXANK CEP250 CAD CDK5RAP1 RANBP1 RRP1B SMARCA4 UBE2Q1 RPL39L IGLV3-21 DNTTIP1 ENDOV SIPA1L3 REEP6 PITPNM1 RHOT2 RBCK1 BECN1 ABCC3 DNAJA3 KCTD5 PKP3 NDOR1 CANT1 URB1 OS9 RHPN1-AS1 MTX1 RECQL5 PTPN23 WFDC3 OXLD1 NSUN2 MRPL21 TMEM101 CUL7 MAN1B1 NDUFV1 ATAD3A WDR18 RAB40C TSR3 DDX51 NOC4L RRNAD1 NOXA1 IMP4 NELFB CATSPERG LMTK3 WDR90 ZNF778 CCT7 WDR34 TMEM79 TMEM175 E4F1 TM9SF4 STX10 POLD1 NPRL3 ZNF213 LMAN2 ATG16L1 MRPL55 SQSTM1 KDM5B ZNHIT1 B3GALT6 CPSF4 ZNF341 GPX4 B3GAT3 SAMD4B CLCN7 FPGS TLE6 FN3KRP TUBG1 MST1 AP5Z1 COG1 CD2BP2 TARBP2 E2F4 DDX41 STXBP2 SNHG7 CTU2 AUP1 TOMM40L THEM6 KRTAP5-AS1 SLC27A4 NDUFS2 FAM86C2P MST1P2 SRD5A3-AS1 POLRMT YKT6 TRPT1 RNF123 MCM7 TRMT12 NAT10 LHPP ROMO1 AURKAIP1 SIRT6 ZNF514 TUFM FAM86DP HARS2 ASF1B RRP9 EME2 TRIM41 SCLY WDR53 RUVBL1 EFTUD2 SRP68 ZNF746 TACC3 GPR137 PPP6R1 TP53 DNPH1 SLC5A6 MRPL20 DDX23 ZNF785 MAP2K2 CCDC124 TMEM9 ENSA MED15 PREB PTOV1 LRSAM1 PSAT1 NFS1 EEFSEC CCDC142 PDXP CUEDC2 MRPS23 CROCCP2 MRPS2 SH2B1 TOMM40 LRRC47 EXOSC2 CACTIN DNMT1 CCDC9 NEURL4 ZSCAN31 AKT1S1 SLC35B2 CHERP POLR1B UBE2M PGLS NCDN SSU72 DROSHA MARK4 NUDC UBAP1 AP4M1 ECI1 IGHMBP2 CHCHD5 TECPR1 UMPS CHMP4B C16orf91 PDF CNPY3 LASP1 MRPS15 SDF4 ZNF764 DHDDS RRP36 PTDSS2 PEX16 HOXC13 NFKBIB PSMC4 HSD11B1L TSPAN10 ILF3 PRR14 PABPN1 SNHG12 GNPTG DDX55 ZNF579 MCM10 TOP3B TMEM129 EDF1 POLR3E PTCD1 DPP7 MTMR4 ILF2 ZMAT2 DLX4 SPHK2 LAMTOR4 PIAS4 EVI5L SAP30BP DIDO1 CIC PCSK4 TPD52L2 PIGG GUSB RAD23A JMJD8 CCDC86 PSMC3 MRPL36 ACY1 DNAJC14 ARFRP1 CTNS G6PC3 MIS18A GRHPR SRA1 IRF2BP1 TBC1D22B SLC35E2B TMEM259 HNRNPUL1 CNPPD1 MED16 RAB11FIP4 ATP11A FIZ1 CCNB1 CCDC130 PHF12 MAF1 GUK1 SNX8 BAX CAPN14 ISG15 AKT2 KIF2C SMARCC1 ZSWIM8 TMEM222 PRMT5 CSNK1G2 RAD9A GCC1 RIC8A TYW1 KRBA1 AIFM1 ALG1 MPG PTBP1 SP2 ADCK1 XAB2 LTBP3 SEC13 CELSR3 PET100 SGTA PSMB5 SLC27A5 ZNF787 SLC38A7 ZNF79 AMDHD2 LMF1 TXNL4A MBD3 CHCHD2 RN7SL521P EPN1 PA2G4 DHRS13 PLAGL2 ZNF839 TUBGCP6 CENPL PPIA PLOD3 SNRNP70 ZC3H18 FAM193B COX19 ECH1 PSME3 PDCL3 ZNF581 THBS3 NAIF1 LINC00881 RFX1 PRSS27 FAM86EP ZNF276 KIF15 TMED1 SHPK NOLC1 MBD1 CS SDHAF1 HPS1 GAA ZNF3 RPL12 RPS2 AURKA MORN4 DHX38 PEX10 NUDT22 RAE1 DDX39A NDUFB9 SPSB3 CTU1 EXOSC6 ZNF398 RPS20 SNRPC ADK GGA1 YIF1A PSMA6 ORC1 URB2 CSK TBC1D17 TTPAL HINFP DPAGT1 DUSP8 CCNL2 GDPGP1 TRMT44 CTSA HSF2BP TAF8 RPL32P3 SLC35A4 GBA PPP1R12C DIAPH1 TBC1D14 C9orf16 EIF5A ZC3H11B SPRYD4 TPGS1 AGBL5 ACSF3 FAM117A RPL36 TOM1 ZNF425 NCAPH2 RUSC1 TMEM160 HSPBP1 CDK11B GEMIN7 PTOV1-AS1 ZNF251 CNIH2 DVL2 RPUSD4 COX6B1 COPS6 NUF2 TAPT1-AS1 MAPK8IP3 PGP GTF3A SNHG9 LMF2 NUDCD3 MIRLET7I STK40 DNAJB11 TMEM53 RPS19BP1 NPHP4 STAT1 SIVA1 TMEM203 DCTN1 PCED1A MED18 CD46 TGS1 NAGPA KPTN MEA1 RBFA SRD5A1 ARHGEF16 CSAD RCCD1 BAP1 TRMU PIN1 RPL27 ZNF688 PROB1 PARS2 FANCD2 VPS51 HK1 AIP TTC31 CDC42SE1 AP1B1 ELP6 ZXDC ZNF252P PRDX6 C1orf74 MLEC DEDD UVSSA PTPN18 KCTD21-AS1 SNRNP35 SSR4P1 NOA1 DPF2 USE1 CENPO WDR81 VPS16 DEF8 GDF15 DDX19A DEDD2 NOS3 ACTR3B VGF CHMP7 PARP3 WDR74 LIN37 ARFIP2 SLC37A3 C2CD2L FRS2 USP42 ABHD12 SKA3 NCBP2 SYNGR4 CDK5RAP2 DSN1 WAC-AS1 SNAI3-AS1 IPPK DGKZ GNA12 DEPTOR STARD3 UBXN1 PSMD8 CIAPIN1 POLG RANBP3 PPP2R1A MRPL44 BAK1 GORAB ZNF524 SMKR1 SEC23B KATNB1 GPS2 CTNNB1 COQ4 XPOT ITGAE MPDU1 RPP40 AP2A1 CHFR RPL27A EXD3 NFKB2 RFT1 PRC1 RPLP2 NDUFS3 ANP32A HNRNPL C11orf72 UQCC1 NME6 SNX11 TP53I3 HSPA8 MTHFSD EPS15L1 APMAP GAK ZBTB17 EP400 ISG20 HIRA RNASEH2C FAM83G KAT5 PPOX CCT4 PSKH1 RNF157-AS1 COQ9 CIB1 ACOX3 TBC1D2 UBTD1 PGAP2 PCBD2 ENPP3 CPSF1 EIF3H MBOAT7 SLC8B1 DNPEP MFN2 ZNF384 MIR4512 DHODH APBB3 RNU6-9 UFC1 DARS2 CKMT2-AS1 ADPRHL2 NUP155 NOL8 ZNF281 CANX SMIM4 SHC1 ZNF584 TOP3A RPL26L1 RTN4R MTHFR ASNS TAOK2 COPS7A ZNF497 ZCCHC9 NAPA GALNS MZF1 FBXO45 COPS5 ADNP ZNF740 THAP3 MTCH1 CKLF-CMTM1 AGFG2 ZSCAN20 ALG8 MANBAL ZNF445 ACO2 NUP214 BAD MIR4258 WRAP53 ALG12 ZC3H8 TTLL11 FAM13A MCAT MIR210 BRIX1 CCDC115 METTL17 ZNF689 VRK3 TYW5 SZRD1 TUBD1 NUDT5 DMWD VKORC1 GGNBP1 ACLY ARHGAP22 BANP HSDL1 CSTF1 HTRA2 BCL2L2-PABPN1 ZDHHC5 PPP1R8 MADCAM1 RPS7 NAPA-AS1 TRAFD1 BOK-AS1 down
## MIR3606_3P 0.0019342 0.0047852 0.4915648 2.603461 0 332 SNCA CYBRD1 RANBP3L SLC6A4 RAB8B HACE1 CCDC39 RUNDC3B CTDSPL2 LSAMP RFX3 PPARG CACNB4 RXFP1 CDH19 LEPROT GAB1 SH3GLB1 SEMA5A SLC7A14 CHST9 APPL1 PTPRB FSD1L RBMS3 TPRG1 PAQR5 ENKUR FEM1B LCORL PTEN PRKG1 ICA1L ELF2 TCF12 LRRC7 TXNDC16 ABHD13 ZNF22 PPP2CB ZBTB8A ZC2HC1A STXBP5 CPEB3 ADAM10 ZNF326 DR1 IL6ST ZFYVE16 PGAP1 SLC26A2 UBE2D3 JPH4 ANGPTL3 PDE8A ARHGAP29 ASAP2 FAM118B CDK17 HDX ABI1 SGIP1 MAP3K4 BICC1 EEA1 C7 RNF103 SCAI PHIP CNN3 CCDC141 ZDHHC2 KALRN CREB1 NAB1 CSGALNACT1 RNF146 SLC39A12 TTC28 FAM133A C18orf54 RELN RNF138 SYPL1 TRIM33 EPHA5 TMEM38B GYPA WBP4 NCBP1 CREG2 SAMD8 MBNL3 RUFY2 NDUFA5 C5orf24 C14orf28 ELF1 SPG11 ANTXR2 KDM6A FAS STRN TBC1D12 CHIC1 RICTOR TMF1 SLC25A46 MTM1 WASF3 TMEM170B PIK3CA MXI1 GNAI3 ZFP28 PRKACB RPS6KA5 SPRYD7 XRN1 EIF4A2 NT5DC1 PPP3CA CDC73 RASSF8 LRRC4C AGFG1 MRC1 FST TMTC3 ZNF148 DTWD2 FMR1 SMARCAD1 TBX18 CARF TNPO1 MOB1B ARG1 ARL6IP6 SERPINB8 FAM171B SAR1A PABPC4L KLHDC1 ITCH GTF2H5 TOP2B UFL1 ZFAND5 FEM1C KIF13A CNOT6L up
## MCM2_TARGET_GENES 0.0020121 0.0047852 -0.6089424 -2.592456 0 76 NCLN ABCF2 TRAPPC9 CIAO1 HDGF FBXL19 PRCC PNKD RAB43 CRTC2 FBXL19-AS1 AAMP TRIM41 DDX23 ORMDL3 UCKL1 GSK3A C1orf159 CHMP4B TSC22D4 PHF23 CLPB CYB561D2 UNK PHF12 FEM1A TUBA1C KLHL22 NPRL2 PHB DFFA ARHGEF5 VPS51 TMEM91 PSMD11 PANK4 TCEA2 AHDC1 SLC16A3 FAM13A TSSC4 BANP C19orf44 DBP TMEM11 TMEM115 down
## MIR513A_3P_MIR513C_3P 0.0019881 0.0047852 0.4756480 2.568075 0 411 SNCA CYBRD1 RANBP3L SLC6A4 RAB8B HACE1 CCDC39 CCDC50 RUNDC3B CTDSPL2 LSAMP RFX3 PPARG CACNB4 RXFP1 CDH19 LEPROT VGLL3 GAB1 ACVR2A SH3GLB1 FBXO8 SEMA5A SLC7A14 CHST9 PREX2 APPL1 PTPRB FSD1L RBMS3 TPRG1 PAQR5 ENKUR FEM1B LCORL PTEN PRKG1 ICA1L ELF2 NCOA1 TCF12 LRRC7 TXNDC16 BAG4 ABHD13 ZNF22 PPP2CB ADAMTSL3 XPA ZBTB8A LAMTOR3 ZC2HC1A STXBP5 SCAF11 CPEB3 ADAM10 ZNF326 DR1 IL6ST ZFYVE16 PGAP1 SLC26A2 UBE2D3 JPH4 ANGPTL3 PDE8A SNX14 ARHGAP29 ASAP2 FAM118B CDK17 HDX ABI1 SGIP1 MAP3K4 BICC1 LACC1 EEA1 C7 KANK4 RNF103 SCAI PHIP RNF111 CNN3 RYBP NUDT21 CCDC141 ZDHHC2 KALRN CREB1 NAB1 CSGALNACT1 RNF146 SLC39A12 TTC28 FAM133A C18orf54 RELN RNF138 SYPL1 TRIM33 EPHA5 TMEM38B PDE11A GYPA WBP4 NCBP1 CREG2 SAMD8 MBNL3 RUFY2 PITPNB TMTC1 EFCAB14 NDUFA5 C5orf24 C14orf28 ELF1 SPG11 ANTXR2 SNX3 KDM6A FAS STRN TBC1D12 CHIC1 RICTOR TMF1 SLC25A46 LIN7C MTM1 MAPK6 WASF3 TMEM170B PIK3CA MXI1 GNAI3 ZFP28 PRKACB RPS6KA5 SPRYD7 XRN1 RASGRP4 FAM135A EIF4A2 NT5DC1 PPP3CA CDC73 RASSF8 LRRC4C AGFG1 MRC1 FST TMTC3 ZNF148 DTWD2 FMR1 SMARCAD1 TBX18 CARF TNPO1 MOB1B ARG1 PLEKHG7 ARL6IP6 SERPINB8 FAM171B SAR1A SETD9 PABPC4L KLHDC1 ITCH up
## RBM34_TARGET_GENES 0.0019920 0.0047852 -0.4463929 -2.560657 0 846 PYGO2 ANAPC11 CDH15 GLI4 TONSL TRMT2A SLC38A10 RPUSD1 SMYD5 CYHR1 ZNF212 FGFRL1 CHPF2 MBD6 P4HB KIFC2 NAT9 FOXK2 NECAB3 FASTK CHTF18 LRRC45 OGFOD3 PDCD6 NMRAL1 CCDC57 PCNT FAM207A PIP5KL1 SNAPC4 CDK2AP2 CRELD2 TRAPPC9 GMEB2 SLC25A10 CHID1 DPH7 LONP1 VPS9D1 AP3D1 ALYREF RANBP1 IRF7 KRI1 SLC35C2 DGCR8 MGAT4B DNAJC5 SOX12 ZNF786 NME4 KISS1R NELFA MRPL38 RAB40C ENO3 APRT ATIC CAPN12 PDIA4 FBXL16 DECR2 ZNF778 TMEM175 ALKBH4 E4F1 E2F1 SQSTM1 LSM7 WDR62 RMND5B B3GALT6 SLC12A9 PKMYT1 MIEN1 YIPF2 SAMD4B CLCN7 IL27RA FPGS SRRM2-AS1 ZNF517 DCXR ATG4D THAP8 MAP3K10 TUBG1 SPG7 MIR4449 STXBP2 CAMK2G EDC4 TMEM177 TALDO1 STK11 TUBB4A ARFGAP1 NUDT1 LZTS2 AURKAIP1 GORASP2 USP39 ETFB SREBF1 TACC3 WDR45B PHRF1 MRPL20 DPP9 SF3B2 EEFSEC MRPS2 VSIG10L MTG1 DNMT1 ADAM15 CAPN1 UNKL TMEM104 RUNDC1 KIAA1522 GFER PPP4C ARPC1B ACTR1B TECPR1 SMARCB1 NMU DHX30 TMEM147 POLD2 SDF4 RRBP1 WIZ HSD11B1L PAXIP1 WRNIP1 DDX55 NBEAL2 RNPS1 ADRM1 MCM10 TRIM28 FN3K TMEM129 MCM4 C15orf39 CCDC12 EDF1 CCDC112 IMPDH1 SYCE2 SPHK2 LRRC37A6P BAHD1 MON1A USP20 TBCD SPPL2B JMJD8 EPS8L2 SPATA2L ZNF653 SEMA4F CNOT11 TMEM259 QSOX1 RHBDF2 HNRNPUL1 ATP11A TCIRG1 ASL HMG20B KMT2B LRRC27 STK32C CIZ1 G6PD YPEL1 CEP55 ARPC5L TCF25 CNNM3 KAZALD1 MAD2L2 RIC8A PPFIA3 WDR83 CTTN ANKRD11 LRWD1 NFKBIE GALK1 LMF1 RN7SL521P NAA40 RER1 ATOX1 ANKRD16 SHMT1 PRSS27 ZNF276 TP73-AS1 ZFP64 ABHD14A PACS1 TOR2A NDUFV3 GAA KPNB1 LRRC59 ELMO2 ARVCF HNRNPU ZNF398 ALAD AGPAT3 GATAD2A OPRL1 FANCA DHCR7 CCNL2 CTSA SCAP HTT POMT2 SRRM2 PGS1 CERS2 CABIN1 HDDC3 BSCL2 LINC00482 PRKDC PKM MOCOS RPL36 IZUMO4 ZNF425 TANGO2 ACTL6B RAB40B MKRN1 ZNF775 PUF60 CFL1 MIB2 XYLB TRIM14 TNIP2 NF2 MAPKAPK3 ZER1 GSTZ1 FAM131A ASB1 FHDC1 SLC7A5P1 RCCD1 SBNO2 TRMU PIN1 NDE1 SLC2A8 ZNF77 HTATIP2 NLRX1 ZNF174 VOPP1 PTPN18 SLC35F2 OAT TPCN2 PSMD11 AMACR MRPS28 C19orf73 TXNDC11 KDM4B ABHD14A-ACY1 SNAI3-AS1 PANK4 MEF2B MOB3A UCK1 KCNK5 BCKDK MKNK2 NUB1 PSD ITGAE RALGDS C2orf68 ZNF367 CLN6 RPLP2 ZSCAN32 ANGPTL6 MAFG FRMD8 FANCE APMAP UNC93B1 GAK REEP4 HIRA RNASEH2C DANCR RPL35 SPIRE2 SLC1A5 ZNF837 AHDC1 PGAP2 RIPK1 COX4I1 NOD1 PROKR1 CPSF1 PLCG1 FLYWCH2 IMPA2 ASH1L PDIA3 MTDH TTLL12 MORN1 down
## MIR607 0.0020661 0.0047852 0.4427035 2.555446 0 906 FAT3 GIPC2 PEAK1 MTMR10 GPM6A PLSCR4 PDS5B TACC1 LRCH1 ATXN3 MITF SLIT2 RECK RAB8B PGR KCNT2 TTC33 REEP1 BMPR2 CD302 CYP2U1 MAMDC2 GNAQ RFX3 ZEB2 CACNB4 STX12 SSBP2 CASQ2 NEGR1 ERCC6L2 CD93 VGLL3 FAM13C FOXF1 ACVR2A C9orf72 NFAT5 RNF144B SCML1 PDCD6IP NEK7 SEMA5A GDA SERINC1 NEK1 FBLN5 PREX2 PAX6 APPL1 PTPRB VAMP4 ARL13B FSD1L EXTL2 RBMS3 SH3BGRL EOGT CNTLN PRKAA1 CNKSR2 SYNPO2 FEM1B HMGCS1 DNAH10 LCORL ABCA9 PLXDC2 CDH6 PCDH15 FGF7 AGAP11 PRKG1 LIN7A DGKH PSIP1 KCTD12 SV2C USP33 QKI CTBS TLL1 PDE8B PTPN12 MAP7D3 TCF12 AK7 IL5RA RORA RFTN2 RSBN1 NFIA ABHD13 TRPC1 SERPINB3 POLR2M ZBTB8A UBASH3B ZDHHC14 PRDM5 FAM124A STXBP5 GABPA NRG3 UNC5C PPM1L DOK6 ABHD5 TBC1D1 REPS2 ZFYVE16 PGAP1 STARD4 ACAP2 GNE AKAP11 CDK6 NPY1R KLF6 USP46 SLC25A24 TWSG1 PURG GUCY1A2 CORO1C DNM3 BTBD3 DENND4A BACH1 SLFN11 PLEKHA1 CRYZL1 ITM2B NAA16 CDK17 KLF10 FIGN SHISA9 KL GABRA2 ATP10D LBH BICC1 PPIL6 ARFGAP3 RAG1 ATG4C PBX1 ITM2A BIVM SCAI RAB11FIP2 LACTB AZI2 SCARA3 HOXD8 ADAMTSL1 PHIP AQP9 C15orf41 FOXN2 BLOC1S6 IQGAP2 NUDT21 PKD2 CCDC141 TTC39B KANSL1L KALRN CREB1 PDLIM5 MTMR9 CDC14A PIAS2 TEX10 ZNF471 TSHZ3 ENPP2 PTBP2 BACE2 ZBTB44 EDIL3 MTMR2 FAM133A DKK2 C18orf54 SYPL1 ZMAT3 CHM RNF180 SLC16A1 LATS2 CPEB1 KIAA0408 WDR17 CYP4V2 USP53 FAM120B SLC30A7 INO80D TMTC2 UBE2B SAMD8 ZDHHC15 ATP2B1 JAG1 MYO5A MBNL3 RUFY2 PCNP PRSS23 NDUFA5 IGF1 RNF149 TTC14 PNISR NR1D2 SPOPL RBM18 USH2A ALG10B MTSS1 KLHL9 GPR26 TRAK1 CNTN4 STRN TBC1D12 IDI1 DCX UBTD2 CHIC1 MFAP3 RICTOR TMF1 SMAD2 NMBR SLC25A46 PPP6R3 BMP2K ARL5B ONECUT2 SYPL2 TMEM170B PIK3CA SLC44A1 FAM13B CEACAM8 EDNRA MGAT4A RCHY1 TNRC6B LRRC58 C1orf146 KIAA1841 IKZF5 CASP1 SP1 GTF2A1 MAP3K2 RBBP9 ZKSCAN8 PRKACB IGIP ADAM22 SDK2 ZNF770 DIP2B HTR1F GPR88 LRP2BP TMED7 VPS26A ETV1 OSTM1 PDHB ZCCHC2 TM9SF3 GPATCH11 PPP2R2A FGL2 C8orf34 AGFG1 HAPLN1 DLD PLSCR1 FOXO1 THSD7A DEPDC7 HSPB3 SPAG9 CFTR GMNC FMR1 PAFAH1B2 ENPP1 DBT KLF12 TRPC6 ZBTB1 SPAG16 MAP3K7 PREPL GJA1 CBFB MOB1B AGPS ST8SIA2 ESRRG ZFP91 MSRB3 PCMTD1 STXBP4 STEAP2 ERP44 SKAP2 KLHL2 TFEC ZNF112 CD83 COMMD2 PCSK1 LZIC INTS6 SWAP70 GNG2 RAB12 CSMD2 SRGAP1 GPNMB ARL5A MXD1 IRAK3 CCNYL1 ZNF546 SPCS3 ARIH1 ITGB1 TMEM59 PDZD2 MMP16 ZFR FEM1C KIAA0825 SMAD5 RCAN2 FBXO30 CNTN1 CTSS HNRNPR API5 HK2 MEDAG CERS3 PSG3 COBLL1 NLK CDKL1 TMX1 FYTTD1 USP1 MIB1 ACTR2 ARL6IP5 FLT1 MSX1 SLC35A3 MCFD2 ZNF518A IMPA1 HOXD3 AP1G1 PPP4R2 RASA2 up
## ZNF436_TARGET_GENES 0.0020202 0.0047852 -0.4682036 -2.536675 0 429 PC RHBDL1 TRAF2 SLC38A10 TMC6 C4orf48 GTPBP3 LRRC45 ARHGEF19 SUPT5H TRAPPC9 TRMT1 MTND5P11 FBXL19 TMEM59L LONP1 CIT BCAS4 SYNGR2 RFXANK LZTS3 REEP6 PIH1D1 MTX1 TCF3 KISS1R NELFA APRT ATIC NELFB CATSPERG PKMYT1 ATG4D ABCA7 MAP3K10 FBXO2 RNU5A-1 PACSIN3 SHKBP1 ATP6V0E2 RGS14 KLC3 SIRT6 ZNF514 SREBF1 ZNF746 GPR137 PRKCSH SPINT2 TNFRSF18 SH2D3A EEFSEC TMPRSS9 TIMM44 VSIG10L CACTIN UNC119 PGLS TFCP2L1 ACOT8 TRPV1 GFER ZSCAN25 DDX11 LASP1 KLHL17 POLM HSD11B1L PRR14 EPN3 CNGB1 MAP1S NBEAL2 PRKD2 SCAMP4 BTBD2 PFKL CCDC12 DPP7 ADAT3 ETV4 ZMAT2 CIC PCSK4 SYTL1 RBM42 SPDEF SMARCC2 MYO7A TSC2 SEMA4F TMEM259 CIZ1 DVL3 GAMT AKT2 HID1 GRB7 MAP3K11 LAD1 ZSWIM3 PLD3 TMEM132A NOSIP YIF1B SF3A2 LRP8 NEK6 CD7 ECH1 RAI1 THBS3 ADCY7 PRSS27 MVB12A IQCE TSPAN31 PRR22 AURKA PTK6 PPP2R2C HNRNPU GGA1 PAK4 CSK PRMT1 FCHO1 NDUFB10 PIM3 NUDT14 KXD1 STARD10 CUX1 RHOBTB2 SYNGR3 SPATA20 HAGHL MT-ND4 ARHGEF16 PLEKHA7 TRIM62 POLR2F CCDC71 RHBDF1 RHOF KISS1 SARS2 CERS4 UBXN6 NKPD1 CTSW CMTM8 MRI1 TMC8 CDIPT PACSIN1 MTHFSD TGFBR3L MAST3 AMBP FAM83G PROSER2 S100A9 FKBP8 ACOX3 PLIN4 down
## MIR3646 0.0020202 0.0047852 0.4404485 2.528137 0 797 FAT3 LYVE1 GPM6A ANO6 PDS5B FMO2 SVEP1 KCNA1 ANGPT1 SNTB2 SORBS1 SEMA3D MYCT1 CCDC50 BMPR2 BCO2 EDAR CTDSPL2 CALCRL LSAMP SH3D19 RFX3 C12orf75 CACNB4 ACKR4 TCF4 VGLL3 AKT3 ACVR2A NFAT5 DNAJB4 RNF144B SCN7A PDCD6IP ZNF280D SPTBN1 PAX6 APPL1 HIPK3 KIAA1324L FBXL5 PAFAH1B1 FSD1L RBMS3 WWC2 ACTN2 POLK FGF14 AJAP1 KCTD9 PLXDC2 GPM6B ABCB5 PRKG1 LIN7A DGKH KCTD12 HMBOX1 CCDC170 QKI CTBS VAV3 USP47 PIK3R1 CDK15 PABPC5 RORA ABHD13 RAB3B OGFRL1 PPP2CB SGCD SH3TC2 ZMYM4 OLR1 UBASH3B SMCO3 LPCAT2 ZNF227 BNC2 LZTFL1 CPEB3 MAPRE2 GABPA CAT STX7 UBE2D3 FFAR4 TTPA SPEF2 AKAP11 CDK6 PDE8A GUCY1A2 MYSM1 NFYB APPBP2 GADL1 OSBPL8 PLEKHA1 VWA3B TCEAL7 NDFIP2 CLEC12A CDK17 TET2 CGGBP1 CCDC82 FIGN CLDN16 ZNF365 SGIP1 CCDC89 KL GRID2 FER LIFR RAG1 GPR85 MEIS2 SEC63 XPO4 EEA1 ITM2A RSPH3 SCAI DZIP1 WDFY3 HIPK1 SOX6 PHIP PAN3 FOXN2 SNAP23 LOX PLCL1 PKD2 KCTD3 SLC30A4 CXCL12 EBF3 UBL3 CNEP1R1 KALRN CREB1 TMED5 MKLN1 PDLIM5 PIAS2 NAB1 NKTR BBS10 SENP7 TMEM236 POTEJ EDIL3 MYT1L USP8 SOX21 VPS29 C18orf54 SNX1 ZMAT3 CHM RNF180 CFL2 SLC16A1 TRIM33 ALOX5 DNAJC27 EPHA5 CPEB1 TMEM38B KIAA0408 FBXO42 UTRN C6orf118 SLC30A7 INO80D LATS1 BCAP29 SOGA3 SAMD8 ZDHHC15 BRWD1 MBNL3 INO80C PCDH17 USP34 GPR34 PCNP ID4 PNISR POT1 RNF152 EBF1 SPOPL CFH RALA NPR3 TRAK1 RSU1 SCN11A STMND1 BVES RICTOR CCDC88A LRRC40 ZNF292 GRPEL2 CSNK1G3 PPP6R3 LIN7C TMEM170A CLIC5 MTM1 MAPK6 CCDC148 CCL16 NWD1 ONECUT2 GNG4 GDAP2 ASB5 GDF6 PIK3CA SLC44A1 TRIB2 RMND5A MGAT4A RCHY1 GRID1 SPIN1 EBF2 IKZF5 TBC1D32 FREM1 MAP3K2 ZKSCAN8 PRKACB SERPINA10 ZC3H12B CUL4B HNRNPLL TRA2B SOCS6 XRN1 MAPK8 REST LRP2BP NRXN1 VWA8 KAT6A SGTB DZIP3 ZMYND11 TMED7 PLCXD3 MYCBP2 MAP2K4 RFX7 FGL2 COPS8 CD200 FOXO1 ZNF148 RAB28 CDH11 KMT2E ARFIP1 DTWD2 PDK3 SMARCAD1 KLF12 TNPO1 ZNF704 SLC1A2 CRY1 PEX3 WAC CBFB ZBTB6 DPYD PLEKHG7 CBL PCMTD1 RAD51B BACH2 TFEC TBCEL ATAD1 BAZ2B INTS6 AAK1 ATP2B2 ITCH LDHAL6B RLIM TFPI AKAP6 GPNMB MXD1 IRAK3 PXDNL RASGRF2 KPNA4 TMEM135 TMEM59 GLMN CD86 CNOT6L UNC5D EXOSC3 HNRNPR LTBP2 MYNN ZFX CEP290 POC1B NPL PPTC7 TCEANC2 HGF ZNF519 TP53TG3D TMX4 RASA2 ZBTB20 ORC4 VTA1 PRELID2 SPATA13 FAM204A DPM1 FSTL5 VPS37A FGF12 AMDHD1 GPR158 GSK3B UBA6 PRKCE FILIP1L CEP97 GPC6 GUCY2C PUS10 CCDC144A GATAD1 KCMF1 ERAP1 SMARCA5 ZNF800 ARHGAP42 LARP4 ATG5 FAM168A up
## SETD7_TARGET_GENES 0.0019763 0.0047852 -0.4402929 -2.512173 0 786 FLAD1 EEF1D PYGO2 RECQL4 PABPC1L GPATCH4 TLCD1 NPM3 MTG2 CHPF2 ISG20L2 ZNF687 MRPS34 ATXN7L3 TIGD5 ARHGEF19 RABL6 APEH PCNT MRPL12 NIT1 C8orf82 HSPA5 CSNK1D CAPN15 ANKRD13D UFSP1 SRCAP MRPL28 PFDN2 PLEKHN1 RPS6KB2 GGA3 FTSJ3 RABEP2 LRRC14 SIRT7 SPATA32 C19orf48 NCL CHD8 KRTCAP3 RCC1 ZNF598 KCNC3 KMT2D WDR18 RRNAD1 ONECUT1 DECR2 TRAF4 PNKP JSRP1 STX10 SBF1 COMMD5 ZNF213 NOP14 SQSTM1 KDM5B PKMYT1 YIPF2 GPX4 EPHA1 LSR SNORD104 FPGS SRRM2-AS1 ZDHHC8 MST1 ING5 SIL1 MIR4449 BCL9L RNU5A-1 EDC4 GAS5 ERGIC3 CBX3 PHPT1 TALDO1 SUOX CSRNP2 TM7SF2 THOC6 MCM7 NAT10 NT5C NOP2 HMGA1 AURKAIP1 TUFM FASN EME2 AHCY RNU4-2 STUB1 MRPL20 PMF1 KIF22 P2RY11 PTOV1 PSMC5 PRR7 SH2B1 DDX54 MTG1 MAP3K14-AS1 DYNLRB1 RNU4-1 SLC35B2 CHERP MFSD10 ACADVL MALAT1 PGLS SSU72 VPS28 AP4M1 ARPC1B DYNLL2 CDCA5 PDF ALDOA RNU5E-1 PATZ1 SNHG12 DNASE1 PRKD2 TRIM28 GRWD1 MAZ NOP56 FAM20A RPS10 DIDO1 RAB24 UBE2S TRIM65 FBXW9 EPHX3 JMJD8 ZNF653 HNRNPA1 ZC3H4 ACIN1 SRA1 SLC35E2B HNRNPUL1 THOC5 CCDC130 POLE RANGRF TMEM63A CYTH2 MAP3K11 CHMP4A DYRK1B SUMF2 LPAR2 POLR2A IMPDH2 BUB1 SAMD1 GART CHMP2A AMDHD2 EPN1 ARSD AVIL SETD6 FAM193B COX19 ZNF581 THBS3 LINC00881 PRR7-AS1 CCDC106 ARPC1A EIF4A3 RRM2 CCND1 MBD1 PACS1 KPNB1 ANP32B TMEM179B RPS2 MYH6 TEAD2 ZNF580 POMT1 KLHL35 EXOSC6 PHYKPL HNRNPU ZNF398 AGPAT3 PLEKHG2 C12orf45 CSK PRMT1 SLC26A6 EIF5A SRRM2 PRELID1 CACYBP MPV17 GPC4 RUFY1 NEK8 PKM CDC6 PFKP MIDN ELL3 RUSC1 PTOV1-AS1 TNFRSF25 FAM83E DVL2 H1FX-AS1 RCC2 ZNF775 TNFRSF12A SNHG9 CFL1 MIB2 PTMA TRIM37 MIRLET7I VCP POMZP3 ZNF668 NSD1 INPP5E BRICD5 ZNF821 SCGB3A2 KAT8 GAPDH C12orf65 LHB SFXN5 DHFR CENPJ NINL MRPS28 PCIF1 RAB1B PCGF3 SNHG8 USF2 GATA4 ATL2 TP53I11 RHOF POLG RPS6 RPL22L1 DALRD3 DDOST DTD1 GRSF1 CLTA GALE SAE1 POM121C BSG CSNK1E SLC3A2 USP22 ZFHX2 SIX5 HEXIM2 RPL27A ZNF577 SLC25A42 HES6 ZNF367 RPLP2 down
## NPAT_TARGET_GENES 0.0020367 0.0047852 -0.4987302 -2.502878 0 204 JMJD4 SNAP47 TRMT2A SMG5 RRP1 FBRS LONP1 FADD CEP250 RANBP1 SMARCA4 ENDOV ASPSCR1 EMC10 DNAJA3 NVL MAN1B1 TMEM79 NPRL3 MLST8 LSM7 BLOC1S4 CDK12 ATP6V0E2 MST1P2 EHMT1 SIRT6 SRRM5 PPP6R1 FAM71E1 PREB CROCCP2 VMAC SNORA14B ENTPD6 ARMC6 NDUFA11 IRGQ CCDC12 PHF23 SPPL2B HNRNPA1 MIS18A LRRC27 STK32C PHF12 FAM220A HMGB3P22 THOC3 SAMD1 TIMM13 GNB1L FAM222B SIN3B PDRG1 CD320 HINFP PGS1 FXR2 THAP7 FAM24B RPL36 GPI MCRS1 GTF3A VPS26B SAYSD1 BNIP3 DAGLB LARS2 RPL27 VPS51 YEATS4 TMEM141 RNF19B DPF2 NUP93 DEDD2 CHMP7 NCAPD3 RANBP3 TOLLIP FUT8 PAGR1 SEC61G HNRNPL RPRD2 SLC2A11 ZBTB17 SUGP2 PRPF31 down
## ZC3H11A_TARGET_GENES 0.0019493 0.0047852 -0.4330414 -2.480444 0 811 DUS1L PSMG3 JMJD4 SNAP47 USB1 NPLOC4 SHARPIN NOL6 SNRNP200 MBD6 GTPBP3 ZC3H3 MRPL24 MRPS34 PARP1 INTS1 CDK5RAP3 SUPT5H PDCD6 CCDC57 FAM207A PFAS PVT1 CIAO1 B4GALT7 TBL3 VPS9D1 TRUB2 TARS2 ZBTB45 RFXANK GGA3 DGCR8 EMC10 TSEN54 BECN1 SRRT KCTD5 COL25A1 COMTD1 ZNF786 MRPL21 TMEM101 NUDT8 RAB40C SLC39A3 DDX51 FBXW5 NOC4L SART1 BMS1 NOXA1 TYK2 NELFB GOLGA3 TRADD JSRP1 ALKBH4 MLST8 CACNB3 MRPL55 TACO1 EIF2B4 CPSF4 ZNF341 YIPF2 B3GAT3 UBTF NME1-NME2 DENND1C EXOC7 FBXO2 EDC4 PPP1R37 PSMG3-AS1 MST1P2 PPIL2 LPIN3 THOC6 MPHOSPH10 HMGA1 AURKAIP1 TUFM FASN ASF1B EME2 NUP107 TNRC18 ZNF746 GNL3L RNF187 DPM2 DTX2 FAM98C ZNF74 GPR137 PPP6R1 DGCR2 PRKCSH WDR45B RPL37 MRPL20 KIF22 FAM71E1 HEMK1 MED15 EEFSEC GAS8 AURKB ZNF205 CUEDC2 CROCCP2 SH2B1 EXOSC2 KEAP1 ZC3HC1 NOL12 SSU72 VPS28 DRG2 MARK4 C8G IGHMBP2 JOSD2 XRCC2 WDR24 TMEM147 ZSCAN9 ALDOA NME1 KLHL17 NFKBIB TSPAN10 ILF3 CA11 TUT1 DDX55 NLE1 NBEAL2 GTF3C5 ADRM1 TOP3B DRAP1 MIR1205 UTP3 CCDC12 MAZ THEM4 PTCD1 ETV4 E2F2 SYCE2 TIGD1 RBM28 BANF1 PIGG ZNF76 HNRNPA1 C12orf76 TBC1D13 ZC3H4 TMEM259 INTS5 KMT2B DHX8 MAF1 ISG15 DHTKD1 TMEM63A CYTH2 OSGIN1 TMEM222 COPS7B NOSIP SCAND1 FEM1A LRWD1 SEC13 GART IGLV1-47 SLC27A5 CHMP2A ZNF768 IPO4 RAB11B ILDR1 DHRS13 PPIA PSME3 ZNF581 RFX1 CCDC106 C9orf163 FRS3 SMG8 CD63 INO80B PRRG2 ZNF276 KIF15 TXNRD2 SDHAF1 ZNF554 C8orf33 KPNB1 TRMT112 ZNF580 PMM1 ARF1 RPS20 CCDC88B TRMT44 GBA DIAPH1 AGK SHROOM1 CASP2 BSCL2 NDUFB10 ZNF165 SLC25A16 ACSF3 RPL36 NAPSA AAR2 COMT TRPC4AP GEMIN7 KIAA0100 TMEM41A NUF2 DMAP1 ACACA MAPK8IP3 STX4 RTEL1 KDM3B ZDHHC4 SPATA20 CHMP1A EIF1AD ZER1 CPNE7 C6orf62 TRMU NPAS1 DAGLB HCFC1R1 VPS51 RBBP5 BSDC1 KAT8 OLFM2 MLEC TTC1 SSR4P1 TPH2 GDF15 GEMIN5 PSMD11 CWC25 SLC37A3 ABHD12 CHTOP KMT2C TAF1C GGCX PANK4 MCM5 LTK SLC37A4 DNAJC2 HES4 SAE1 MKNK2 CTNNB1 COQ4 MAFA SMG7-AS1 SSBP4 CHFR SDC4 EXD3 NDUFS3 ZNF408 SAFB AGMAT VPS25 CLK3 GAK EP400 LYN CCDC58 HIRA COA6 PDE4A ACOX3 ENPP3 CPSF1 GEMIN4 CHD2 ACP2 TPI1P2 NOL8 NDUFS7 SMG7 RTN4R STOML2 KNTC1 RUNX1 ADNP ARL6IP4 DUS2 CLASP1 NKAP SPATA33 NUP214 RTEL1-TNFRSF6B EIF4E2 DDIT3 down
## MIR579_3P 0.0019881 0.0047852 0.4522059 2.472843 0 470 FAT3 GIPC2 SULT1B1 GCOM1 MMRN1 PHACTR2 ANGPT1 PLAC8 KCTD16 SNTB2 PKN2 PRICKLE2 SORBS1 TMEM220 CAV2 NCKAP5 OSBPL6 CTDSPL2 MAMDC2 LSAMP GNAQ SH3GL3 CACNB4 NTNG1 RAP1A IL22RA1 VGLL3 ACVR2A FRYL NEK7 ARHGAP28 CALM1 SOBP SERINC1 CTNNAL1 DPP8 WWC2 ACTN2 DGKE GPM6B LRRC19 ROBO2 DGKH QKI PHLDB2 CAPN7 FNIP1 PIK3R1 BMPR1A SEC24B DLG2 AP1S2 RAB3B OGFRL1 POLR2M SH3TC2 ZMYM4 CPT1A SSPN APBB2 MYRIP HOXD10 STXBP5 MAP4K5 HSD17B12 GABPA PPM1L ZNF326 IL6ST LONRF1 MAATS1 STAG1 CDK6 CDK14 GUCY1A2 DNAI2 CTTNBP2NL DENND4A OSBPL8 ELP4 DNAJB14 NTM KLF9 NDFIP2 MED4 SGIP1 SMIM8 XPO4 MEGF11 CLEC12B C1orf141 PHIP F5 IQGAP2 RHOQ PCDH18 NTRK2 CEP57L1 UBL3 PIAS2 NKTR SENP6 NFIB B4GALT6 LRRK2 OMG UVRAG LAMP3 SYPL1 CHM TAOK1 WWTR1 GYPA AQP4 FAM76B KIAA1549L LIMS1 METTL14 MBNL3 RUFY2 GPR34 ZNF347 C2CD5 FAM98B ANTXR2 IGSF5 USH2A KLHL9 NR2F2 TBC1D4 SLC6A2 APC TMF1 HNMT CSDE1 CLIC5 CCSAP STMN2 ATP2C1 PIK3CA LTBP1 RMND5A PJA2 NPY5R IKZF5 GLDN ADAM22 CUL4B ZC3H6 ANKRD10 ZNF655 PPFIA2 SLC10A2 NCK1 SETX KCNN3 AK3 ZBTB34 B3GNT5 CDC73 SLC4A4 AGFG1 HEY2 STAG2 THSD7A TMEM200A TMTC3 ZFP14 DENND4C ATE1 DBT KLF12 EPHA3 ZNF704 MAP3K7 CCNC GJA1 MOB1B SWT1 AGPS BACH2 ERP44 RAB23 ATAD1 LRRTM3 PNPLA8 NLGN1 SRGAP1 ARL5A QSER1 RASGRF2 UFL1 TMEM135 ANO5 TTC17 LSM11 NCEH1 FAM83B TEAD1 ITGBL1 PPP1CC COBLL1 ZFX FBXO21 SLCO1A2 POC1B up
## MIR548N 0.0019608 0.0047852 0.4425410 2.468842 0 568 REV3L LYVE1 GPM6A FMO2 PKN2 HACE1 ABI3BP MICU3 BMPR2 TAL1 EMCN ZEB2 ABCA8 PPARG CACNB4 NEGR1 SLC38A2 UNC45B ZNF106 VGLL3 C2orf73 FOXF1 ACVR2A C9orf72 NFAT5 DNAJB4 USP12 SCML1 PDCD6IP NEK7 SOBP CHST9 APPL1 DPP8 ARL13B SH3BGRL PRKAA1 INSIG1 GNG12 GPM6B ROBO2 DGKH DENND6A HMBOX1 QKI CPNE8 OTUD1 CHIC2 TRPC1 TMOD2 CREBRF LAMTOR3 VWC2 KCNK2 STXBP5 MAP4K5 GABPA RBFOX2 ZNF326 STOML3 PGAP1 UBE2D3 SAV1 KITLG CDK6 PTPRG SLAIN2 HS2ST1 SEMA3C PURG AKAP7 ARHGAP29 EXOC6B ASAP2 OMA1 APPBP2 OSBPL8 ADAMTS9 CLMN FGD4 CLASP2 SKIDA1 KLF9 DAAM1 SGIP1 UBR3 VPS13C BICC1 EEA1 BIVM PCDH10 SCAI HERC1 MEGF11 SLC9A2 EMP1 LACTB VIM MAP4K3 SOX6 RAP2A PPIP5K2 RYBP IPMK BMI1 APLF PDLIM5 DNAL1 ANGPTL1 CACNA2D3 CCP110 BBS10 LANCL1 B4GALT6 RAB33B TAOK1 MAPK1 CFL2 ZNF99 TRIM33 FRMD4A EPHA5 SLC30A7 RHOT1 C4orf33 PROK2 SNX16 CCNG1 LATS1 SERINC3 UBE2B ZDHHC15 FAM76B BRWD1 DCDC2 RUFY2 TMTC1 C4orf19 C5orf24 C14orf28 GATM PNISR TSPYL6 CDKL5 ALG10B SNX2 PPM1A MEF2C KAT6B CHIC1 CCDC88A SS18 SPHKAP NUP54 LIN7C DIS3 RMND5A MGAT4A TNRC6B LRRC58 HAUS2 FUBP1 SP1 MAP3K2 UFM1 PRKACB TRIM58 ADAM22 BTG1 ZC3H6 ANKRD10 TRA2B SOCS6 XRN1 FAM135A AK3 NRXN1 SCP2 ZBTB34 SGTB ARPP19 INPP5A PHTF1 MZT1 TM9SF3 CXCL5 SMAD1 SLC4A4 AGFG1 ERLIN2 STAG2 USP44 THSD7A TMTC3 IVNS1ABP COL12A1 SLC35D1 DMTF1 SOX8 C11orf87 EXOC5 FOXG1 B3GALT2 SMARCE1 MOB1B ZBTB6 KATNAL1 FLRT3 ARL6IP6 EGR2 ZFP91 INTS6 LPP CTNNA3 TIAM2 GPR137B CLCC1 FAM200B GJC1 MAF ARIH1 TEX36 GATA2 ZFR CNOT6L UNC5D CNTN1 HNRNPR SEC22A up
## MIR10527_5P 0.0019493 0.0047852 0.4413498 2.461153 0 558 MTMR10 GCOM1 ATXN3 PHACTR2 PRICKLE2 SLC6A4 RAB8B APH1B PGR KCNT2 STON1 OSBPL6 ACER3 CALCRL RFX3 SH3GL3 CACNB4 FIBIN DOCK4 VGLL3 PMP22 KCNAB1 NFAT5 DNAJB4 PXK SOBP APPL1 HIPK3 PGM5 MEOX2 FSD1L PLP1 TPRG1 CNKSR2 ATG2B MS4A7 ADRA1A KCTD9 PLXDC2 ROBO2 USP33 QKI CTBS VAV3 PKIA KCNA5 DLG2 RSBN1 OGFRL1 DOCK11 POLR2M MRAP2 FOXP1 MIER1 PCGF5 STXBP5 MAP4K5 BNC2 CHRDL1 ADAM10 PPM1L ZNF326 SSTR1 TBC1D1 CD109 STOML3 LONRF1 MAATS1 KITLG TTPA DGKG AKAP11 KLF6 CTTNBP2 SLC25A24 CDK14 CA5B DNM3 CTTNBP2NL PARVA CEP57 CDK17 ABI1 TET2 DDHD1 KDSR SGIP1 MYOCD FGFR2 VPS13C LBH ZNF662 SCAI SLC9A9 RAB11FIP2 WDFY3 HIPK1 PPM1D SLC10A7 RABGAP1 PAN3 BLOC1S6 RYBP CCDC18 ACSL4 BMI1 PCDH18 CMTM6 SYNJ2BP TUSC3 LRIG2 MKLN1 PIAS2 YBX3 TSHZ3 CCP110 CMPK1 ROCK2 AFF1 MFAP3L B4GALT6 JAKMIP2 SSH2 SPTSSB PTPRM CACNA1C SYPL1 ZMAT3 CHM MAPK1 LATS2 INO80D FRMD6 SNX16 RAB14 SCHIP1 MATN3 EXOG USP34 IGF1 DMXL2 BACE1 NIPSNAP3B SNX3 DTNA FAM171A1 CNTN4 MNDA MEF2C FGFR1 CCDC88A MN1 NRG1 BBS2 UBE3A CSNK1G3 CSDE1 LIN7C BBX ONECUT2 GDAP2 ASB5 SECISBP2L FSTL1 RMND5A PJA2 SPIN1 TNRC6B HAUS2 ACADM ZNF143 EBF2 SP1 GTF2A1 NEBL MAP3K2 ATF2 PKD2L2 PUM2 ASTN1 EPM2AIP1 USP24 SCP2 PLCXD3 CHMP2B B3GNT5 ETV1 ARPP19 SLCO3A1 LRTM1 SBSPON CDC73 MID1 AGPAT5 CLIP4 TMEM30A C11orf45 CDH11 KMT2E PRRX1 SHOC2 TXLNG TNPO1 ZNF704 PREPL DYRK1A EXOC5 SLC35B4 THBS1 KATNBL1 ESRRG ZFP91 MSRB3 ST8SIA3 BACH2 up
## MIR664B_3P 0.0019920 0.0047852 0.4486306 2.453305 0 465 FAT3 GIPC2 SULT1B1 GCOM1 MMRN1 PHACTR2 ANGPT1 PLAC8 SNTB2 PKN2 PRICKLE2 SORBS1 TMEM220 CAV2 NCKAP5 OSBPL6 CTDSPL2 MAMDC2 LSAMP GNAQ SH3GL3 CACNB4 NTNG1 RAP1A IL22RA1 VGLL3 ACVR2A FRYL ARHGAP28 CALM1 SOBP SERINC1 CTNNAL1 DPP8 WWC2 ACTN2 DGKE GPM6B LRRC19 ROBO2 DGKH QKI PHLDB2 CAPN7 FNIP1 PIK3R1 BMPR1A SEC24B DLG2 AP1S2 RAB3B OGFRL1 POLR2M SH3TC2 ZMYM4 CPT1A SSPN APBB2 MYRIP HOXD10 STXBP5 MAP4K5 HSD17B12 GABPA PPM1L ZNF326 IL6ST LONRF1 MAATS1 STAG1 CDK6 GUCY1A2 DNAI2 CTTNBP2NL DENND4A OSBPL8 ELP4 DNAJB14 NTM KLF9 NDFIP2 MED4 SGIP1 SMIM8 MEGF11 CLEC12B C1orf141 PHIP F5 IQGAP2 RHOQ PCDH18 NTRK2 CEP57L1 UBL3 PIAS2 NKTR SENP6 NFIB B4GALT6 LRRK2 OMG UVRAG LAMP3 SYPL1 CHM TAOK1 WWTR1 GYPA AQP4 CREG2 FAM76B KIAA1549L LIMS1 METTL14 MBNL3 RUFY2 GPR34 ZNF347 C2CD5 FAM98B ANTXR2 IGSF5 USH2A KLHL9 NR2F2 TBC1D4 SLC6A2 APC TMF1 HNMT CSDE1 CLIC5 CCSAP STMN2 ATP2C1 PIK3CA LTBP1 RMND5A PJA2 NPY5R IKZF5 GLDN ADAM22 CUL4B ZC3H6 ANKRD10 ZNF655 PPFIA2 SLC10A2 NCK1 SETX KCNN3 AK3 ZBTB34 B3GNT5 CDC73 SLC4A4 AGFG1 HEY2 STAG2 THSD7A TMEM200A TMTC3 ZFP14 DENND4C ATE1 DBT KLF12 EPHA3 ZNF704 MAP3K7 CCNC GJA1 MOB1B SWT1 BACH2 ERP44 RAB23 ATAD1 LRRTM3 PNPLA8 SRGAP1 ARL5A QSER1 RASGRF2 UFL1 TMEM135 ANO5 TTC17 LSM11 NCEH1 FAM83B TEAD1 ITGBL1 PPP1CC COBLL1 ZFX FBXO21 SLCO1A2 POC1B up
## KLF13_TARGET_GENES 0.0018904 0.0047852 -0.4075800 -2.447370 0 1766 ZNF696 PSMG3 EEF1D SLC25A39 ANAPC11 OPLAH JMJD4 TLCD1 CBX4 SNAP47 CCDC137 C1orf35 TOP1MT INPPL1 SAMD10 NPLOC4 SLC4A2 TRMT2A SMYD5 SNRNP200 MBD6 TMEM134 TELO2 TMEM150A NAT9 PPP1R14B ABCC10 SYT7 MRPS34 PARP1 ABCF2 DHX34 TIGD5 LRRC45 TAF6 CDK5RAP3 MFSD3 PUSL1 IGSF9 RRP1 LETM1 PCNT PIP5KL1 MAST1 GUSBP1 FBXL19 CHID1 BRD9 NIT1 C8orf82 CRLF1 PPP1R35 VPS9D1 CSNK1D AP3D1 CAPN15 PRPF6 ALYREF RFXANK TIMELESS SRCAP RANBP1 PFDN2 RRP1B SMARCA4 AXIN1 TFAP4 ATXN2L ACAP3 UBE2Q1 RABEP2 LRRC14 DGCR8 SIPA1L3 ASPSCR1 MORC2 DNAJC5 EARS2 TSEN54 NCL KCTD5 URB1 OS9 TCF3 UBFD1 SCAF1 LSM14B PTPN23 ZNF598 CUL7 TIMM50 NDUFV1 ATAD3A TSR3 SLC39A3 ENO3 FBXW5 SART1 AGRN APRT NOXA1 ATIC TYK2 NELFCD MYL6B PELP1 CAPN10 NELFB GOLGA3 CATSPERG TRAF4 PNKP EIF6 NOP9 JSRP1 WDR34 BAZ2A CCDC127 MARK2 CRTC1 POLD1 BRAT1 CACNB3 MRPL55 LSM7 ZNF335 ZNF646 HSPB1 MFSD9 SLC12A9 GOLGA2 SCYL1 ARHGAP40 KLC2 GPX4 IQGAP3 BCAT2 B3GAT3 HAX1 SAMD4B NME1-NME2 EML2 ZBTB42 DUSP23 ERGIC1 EBNA1BP2 ODC1 SCNM1 NIPSNAP1 MST1 CLASRP POC1A SNHG7 PTGES2 ZNF628 ZNF239 CTU2 ANKS3 EDC4 GAS5 ERGIC3 CBX3 PPP1R37 MNT PAFAH1B3 ZNF414 PSMG3-AS1 RNF123 MPHOSPH10 MCM7 TRMT12 ROMO1 HMGA1 NMT1 AURKAIP1 USP39 SIRT6 TUFM UGDH CDK4 FASN ATAD3B WDR53 RUVBL1 GRIN1 KCTD21 FAM98C PPP6R1 AIMP2 S100A14 UBE2I STUB1 PHRF1 MAP2K2 DPP9 HEMK1 SLC12A7 SH2D3A SMIM1 PTOV1 EEFSEC HSPD1 ING2 MEGF8 CALR SH2B1 DDX54 MTG1 ZNF500 KEAP1 NEURL4 UCKL1 ADAM15 PRKCZ UNKL GSK3A TMEM104 ZSCAN31 MND1 CMTR1 AKT1S1 CHERP C1orf159 NCDN APC2 VPS28 RUNDC1 VMAC C8G AP4M1 KRT18 DAZAP1 GPRC5C NDUFA11 METTL2B CLPTM1 S100A2 NUP62 CHMP4B USP35 RUNDC3A CDCA5 CCNF LASP1 SNHG11 FANCG RPL8 ALDH18A1 DGCR6L DHDDS PTDSS2 NME1 PATZ1 NFKBIB UBALD1 SNORD46 TSPAN10 ILF3 GRK6 TSC22D4 GNPTG DDX55 NLE1 SWI5 ZDHHC9 SCAMP4 TOP3B ZSCAN2 DRAP1 C15orf39 SIRT3 ANKRD9 MXD3 ZYG11A METTL2A POLR3E PLEKHJ1 ADAT3 SYCE2 POLD4 PIAS4 EVI5L RBM28 MON1A EMC9 RAB24 USP20 CIC TBCD BANF1 SGSM2 RAD23A ATP4A SPPL2B ZNF76 LIG1 EPS8L2 STAG3L5P ACY1 C12orf76 CTNS TBC1D13 BPHL MECR CLPB SLC35E2B ARHGAP33 HNRNPUL1 PPP1R26-AS1 MED16 HAGH MEF2D ASL HMG20B MUC4 CCNB1 LRRC27 STK32C CIZ1 G6PD SFXN4 FBXL8 PHF12 YPEL1 POLE ISG15 CASP6 SLC52A2 ARPC5L MAP3K11 TAF6L PIGM CNNM3 MAD2L2 BYSL HSP90B1 TMEM222 CSNK1G2 RAD9A GCC1 ARID1A TMEM198 DYRK1B PPFIA3 COPS7B NOSIP SF3A2 PTBP1 LYSMD1 LHFPL5 SUPT6H SAMD1 SEC13 SMARCAL1 SEMA4B METRN ZNF787 WRAP73 IPO4 TXNL4A PSMD13 YWHAG TUBA1C DHRS13 FOXO6 CLDN6 ZNF839 TUBGCP6 ANKRD16 SDHA ZC3H18 ECH1 PDCL3 ZNF581 LRFN4 GNB1L LINC00881 CCDC106 C9orf163 FRS3 TMEM201 CDC25A INO80B PRRG2 ZNF276 EIF4A3 RNU5B-1 KLF16 KIF15 NEK2 SHPK NOLC1 DDX31 TBCB ILVBL FRMD5 ATAD2 ZNF3 SIN3B TRMT112 PEX10 GLDC BRPF1 ADCK5 VAMP8 MED20 OGDHL DCAKD HNRNPU ALAD ADK GGA1 ZNF629 DLG3 MSTO1 CHCHD6 URB2 MRPS16 PAK4 CSK TBC1D17 FKBP4 DNAJC11 LMNB1 VAC14 PRMT1 DHCR7 CTSA SCAP HSF2BP TAF8 KRT8 R3HDM2 GBA HTT DIAPH1 TBC1D14 AGK ANLN PAK1IP1 SPRYD4 TOR4A DHRS1 PRELID1 GET4 CENPF CKAP2L NEK8 ACSF3 RPL36 HPCA IZUMO4 MIDN CCDC97 DFFA ZNF784 TSR1 CISH TMEM52 HSPBP1 TMEM41A VPS18 OBSL1 E2F3 TXLNA COPS6 NUF2 DMAP1 EFNA3 ZNF775 MAPK8IP3 STX4 WDYHV1 C11orf24 MCRS1 PUF60 TBL1X RAD54L SLC39A11 KDM3B TRIM37 XYLB TNIP2 BMF MAPKAPK3 POLR2I CHMP1A STAT1 PPAT EIF1AD ZER1 NUBP1 CD46 FAM131A ASB1 ZNF668 TGS1 KPTN PFDN4 SDF2 BCL9 AGO2 MIER2 GALNT11 LARS2 PPP1R3D RNA5SP283 RNF145 CDC42SE1 RBBP5 BSDC1 ELP6 ABHD4 PMS2 ZNF174 CCDC71 SLC35F2 TESK1 RNF121 HSPA9 ST3GAL3 POU2F2 TPH2 CENPA RHBDF1 NAP1L4 WDR45 DEDD2 SOD1 DCAF13 VGF TMEM102 DPH1 PISD SKA3 RHOBTB3 C9orf64 PPP1R13L KMT2C SEC11C GGCX LTK VWA1 MOB3A DCUN1D5 SFT2D2 EZH2 DNAJC2 DTD1 HES4 PROSER1 BCKDK HEATR1 TXN MKNK2 CTNNB1 CHPF SIX5 FBXL6 KIAA2013 SMG7-AS1 RALGDS TNFRSF21 ITPKA LSM10 HEXIM2 EXD3 HELB KDM6B TJP3 ZSCAN32 NDUFS3 HNRNPL ZNF354A C11orf72 ZNF408 NME6 PLIN5 CDCA2 TMEM191A PXMP2 VPS25 CLK3 PPM1J ZFAS1 GFPT1 BTBD9 BAIAP2 ASPH TCEA2 MFSD12 FAHD1 TMEM182 SUGP2 HIRA SETD4 B3GALNT2 RPL35 GPN2 WDR59 CCDC47 PDP2 TBC1D2 PCBD2 IL4I1 ENPP3 AUNIP LIG3 AACS PLD6 MBOAT7 ZNF384 RNU6-9 RPS15 MAN2A2 CD3EAP LRRC41 PGPEP1 ETV2 SMG7 XPO6 NDUFAF6 ASNS ZNF497 KNTC1 RHEB NUMBL SNORA13 PLIN3 FZR1 ATF5 FBXO45 COPS5 ADNP PDXK ARL6IP4 KLK13 STMN1 MTCH1 SERTAD3 SPAG7 RELB FAM217B CDK1 CA5BP1 SPATA33 BUB1B RTEL1-TNFRSF6B PDCD1 COX7C WRAP53 LINC00896 SURF4 PSMF1 PSMB10 BCL7C CYP2E1 TTLL11 UBE3C TXNRD1 CCDC107 KCNIP2 down
## MIR153_5P 0.0020619 0.0047852 0.4220824 2.447090 0 979 FAT3 PEAK1 DACH1 FHL1 PIAS1 DUSP19 TCTEX1D1 C1QTNF7 ATXN3 MITF IGSF10 MEF2A APPL2 GHR RAB8B APH1B RUNX1T1 ARRDC4 CAV2 PGR NCKAP5 CCDC50 LMO2 SNRK ACER3 CYP2U1 FBXL3 LSAMP RFX3 ZEB2 RXFP1 FIBIN NEGR1 SLC38A2 ERCC6L2 PDE1C VGLL3 FOXF1 AKT3 ACVR2A SLIT3 DYNC2LI1 FRYL SH3GLB1 PDCD6IP NEK7 ARHGAP28 CALM1 SEMA5A SOBP SERINC1 PREX2 PTPRB VAMP4 ARL13B GRK5 RBMS1 PLEKHH2 RBMS3 PAQR5 CNTLN ZCWPW2 TLE4 SYNPO2 DGKE FEM1B RAB11A ADRA1A PLXDC2 KLF4 KCNJ3 SPON1 CNTNAP3 DGKH DENND6A HMBOX1 CCDC170 QKI ATP1A2 ARID2 SRGAP2C PABPC5 FBXO11 EFNB1 OTUD1 TRPC1 ZNF22 SGCD POLR2M CNTNAP3B SH3TC2 DICER1 COPS2 APBB2 MIER1 PCGF5 MYRIP LPCAT2 HOXD10 STXBP5 PTPRD OMD LZTFL1 CPEB3 GABPA DDHD2 PPM1L ZNF326 PGAP1 PLG CDK6 EIF4E3 PTPRG NPY1R SLC24A4 SLAIN2 USP46 ARHGAP24 SLC25A24 SEMA3C PDE8A LAYN GUCY1A2 SH3RF3 MYSM1 OMA1 CTTNBP2NL MPDZ NFYB TNKS BACH1 OSBPL8 RNF11 ELP4 TTC7B PLEKHA1 KLHL41 CADPS NDFIP2 RGS18 FIGN SGIP1 MYOCD CYP2C18 FGFR2 RELL1 BICC1 HMGCLL1 PCSK5 DRD5 PBX1 LPL EEA1 ATL3 ALDOB CLEC19A SCAI RAB11FIP2 SOX6 ADAM9 PHIP BNIP3L VPS36 CCDC180 RAB9B SLC22A15 KCTD3 RHOQ NALCN NTRK2 UBL3 CREB1 TMED5 AGMO CAPS2 ENTPD1 CSGALNACT1 ZNF536 NKTR FAM49A USP3 ZC3H12C OSBPL9 SENP6 EPC1 TMEM236 KCNB2 MFAP3L NUDT4 CDKN2AIP VPS29 LRRK2 C11orf16 OMG SYT11 RELN RNF138 RAB33B TAOK1 PDC SLC16A1 TRIM33 SPATA18 EPHA5 KIAA0408 PKDCC FBXO42 PDE11A INO80D ADAMTS3 C4orf33 C5AR1 DSE IGFBP7 VSTM4 VNN1 SOGA3 SELE SAMD8 KIAA1549L LIMS1 PRSS35 DCDC2 MBNL3 NHLRC3 PCDH17 KDM4C GPR34 TMTC1 CALD1 CDC37L1 RBMXL1 BCLAF1 ID4 C2CD5 CD59 PRG4 RSPO3 NR1D2 IFNAR1 SPOPL ZHX3 RFX6 USH2A PCDH9 RALA FAM171A1 FOXL1 THUMPD1 TBC1D4 C6orf120 CNTN4 SNX2 MEF2C CHIC1 TMF1 STON2 SHPRH CHSY1 ERBB4 CCSAP ONECUT2 ATP2C1 GCA TMEM170B ATP8B1 RMND5A RBMS2 MGAT4A TNRC6B TAOK3 CEBPG EBF2 MAP3K2 ZFP28 RASSF6 ARID4A PDCL IGIP RPS6KA5 SLC9A4 CUL4B MS4A14 AUH ZDHHC20 PPFIA2 NUTM1 PUM2 XRN1 DCK OSBPL1A SLC10A2 NCK1 CCDC102B EXOSC8 ALG13 USP51 TMEM168 KAT6A CHMP2B B3GNT5 TBCK PPP3CA NR3C2 ZCCHC2 TM9SF3 CDC73 RASSF8 LRRC4C FGL2 SLC4A4 C8orf34 AGFG1 TMEM30A STAG2 THSD7A TTC8 SLC36A4 LMO4 CYBB WDR41 DENND4C ARFIP1 HLF ATE1 LTN1 TNRC6A ARMC8 EPHA3 TXLNB MAP3K7 AP3S1 FOXG1 CBFB ARPC5 MOB1B ARG1 GPCPD1 AGPS MSRB3 PCMTD1 RAD51B GNAI1 KLHL2 TBCEL PIKFYVE LRRTM3 AAK1 PNPLA8 RLIM TGFBR1 C12orf40 NLGN1 LPCAT4 ZNF566 CTNNA3 DDX6 GTF2H5 IRAK3 KPNA4 CRISPLD2 IPO5 TMEM135 DIRAS3 FRMPD4 PDZD2 MMP16 ZFR ANO5 DPH6 WT1 SMAD5 LSM11 ANXA1 SEC22A NCEH1 KLK7 TEAD1 SRGAP2B ITGBL1 COBLL1 CDKL1 DDX60 NMD3 ATXN1 CUL5 TCEANC2 NAAA NDFIP1 PCMT1 GPATCH2L PYGO1 NID2 MAP4K4 RBPJ PPP4R2 KLHL32 ZNF10 ORC4 ABHD2 AKAP5 VTA1 NAT1 MPPED2 ZNF568 PRELID2 up
## MIR423_5P 0.0019802 0.0047852 -0.5186608 -2.441144 0 129 NACC1 RPUSD1 UBE2O TMEM150A ATXN7L3 ADAR LZTS3 ACAP3 FOXP4 SOX12 PDAP1 PNKD ASB6 SCAF1 FBXL16 DOLPP1 KDM5B BCORL1 SAMD4B ODC1 ATG4D PDXP LRRC47 DDX54 TSPAN11 ZNF500 DAP LASP1 RNPEPL1 KCNIP3 ELFN2 NAT8L COPS7B SCN4A FAM222B PACS1 DUSP8 CELF5 HDDC3 MAP1LC3A TMEM41A OBSL1 STK40 NRSN2 BAP1 CDC42SE1 PYGB MFSD12 CELSR2 SNX19 NNAT DLGAP3 ENC1 S100A16 ARHGEF4 C1QTNF6 DMWD NFIC CLDN23 RAC2 down
## MIR3184_5P 0.0019841 0.0047852 -0.5230917 -2.437709 0 124 NACC1 RPUSD1 UBE2O TMEM150A ATXN7L3 ADAR LZTS3 ACAP3 FOXP4 SOX12 PDAP1 PNKD ASB6 SCAF1 FBXL16 DOLPP1 KDM5B BCORL1 SAMD4B ODC1 ATG4D LRRC47 DDX54 TSPAN11 ZNF500 DAP LASP1 RNPEPL1 KCNIP3 ELFN2 NAT8L COPS7B SCN4A FAM222B PACS1 DUSP8 CELF5 HDDC3 MAP1LC3A TMEM41A OBSL1 STK40 NRSN2 BAP1 CDC42SE1 PYGB MFSD12 CELSR2 SNX19 NNAT DLGAP3 ENC1 S100A16 ARHGEF4 C1QTNF6 DMWD NFIC CLDN23 RAC2 down
## JDP2_TARGET_GENES 0.0019268 0.0047852 -0.4074364 -2.436671 0 1661 ZNF696 EEF1D TRIM11 ANAPC11 JMJD4 CBX4 SNAP47 SMPD4 PC WDR4 CLPTM1L RCE1 KRT80 TRMT2A TDRKH C1orf226 HMBS MTG2 CYHR1 TK1 SNRNP200 ASB16-AS1 MBD6 P4HB TELO2 PYCR1 KCTD13 DNAJB2 KIFC2 NAT9 ZC3H3 MRPL24 USF1 DHX34 MZT2B TIGD5 GID8 SMG5 CBX8 DTYMK OGFOD3 SUPT5H PDCD6 PUSL1 CCS RRP1 LETM1 RABL6 CDK2AP2 PFAS REPIN1 CIAO1 HDGF MRPL12 TBL3 FBXL19 CHID1 ZFYVE27 PRCC USP21 GON4L AP1S1 PPP1R35 CTBP1 TMED9 FADD AP3D1 PRPF6 YTHDF1 ALYREF RFXANK HGS EXOSC5 RANBP1 ACAP3 RPS6KB2 MROH1 LRRC14 NR2C2AP SLC35C2 GCDH DNTTIP1 ATP13A1 ABCF3 ASPSCR1 RHOT2 MYPOP DNAJC5 POLR2D PDAP1 RNF213 DNAJA3 PNKD SLX4 PSMD3 MRGBP LARP1 CHD8 CANT1 MAP3K9 RECQL5 THOP1 PTPN23 WFDC3 RCC1 MRPL38 TRAP1 ATAD3A WDR18 DDX51 FBXW5 NOC4L SART1 POLR2H NELFCD PELP1 SEC16A SARDH JSRP1 TMEM79 TMEM175 CCDC127 ALKBH4 CRTC1 SBF1 E2F1 MRPL55 ZNF335 ZNF526 ZNHIT1 ACAD9 ZNF7 BLOC1S4 NCOA5 YIPF2 UBTF CCT5 HAX1 B3GNTL1 TBCC CDK12 ZNF517 TLE6 SCNM1 TUBG1 SPG7 MST1 ING5 SIL1 CC2D1B SRM CLUH EIF2AK1 PSMD2 RRP12 FBXL19-AS1 BCL9L RNU5A-1 UBE2J2 CBX3 MNT PHPT1 SIGIRR ATP6V0E2 SLC22A18 POLRMT YKT6 SNHG3 AAMP RPL38 RNF123 MCM7 HAUS5 NAT10 EHMT1 NMT1 HSP90AB1 USP39 SIRT6 ZNF514 CDK4 ARL16 XPO5 SREBF1 NUP107 ACBD4 WDR53 SRRM5 RNF126 PPP6R1 U2AF2 MRPL20 KIF22 DDX23 DPP9 COPG1 CCDC124 KDM2A RANGAP1 MED15 SLC4A1AP MCM3AP-AS1 PREB PPP1CA TMED3 CBR3-AS1 TMEM63B PTOV1 HSPD1 PDXP MRPS23 TIMM44 ORMDL3 ANAPC2 MTG1 CACTIN C1orf122 UCKL1 GSK3A TMEM104 CMTR1 AKT1S1 CHERP C1orf159 MALAT1 FOXRED1 NCDN SSU72 ACOT8 PABPC1 MAGEF1 INPP4A C8G AP4M1 GFER SNORA14B ACTR1B ENTPD6 ENO1 FITM2 ARMC6 CCDC51 DYNLL2 XRCC2 CHMP4B RNF43 C16orf91 CDCA5 SSNA1 SNHG11 MRPS15 RPL8 DHDDS RNU5E-1 WIPI2 GNAS IRGQ PEX16 SCFD2 CDYL SNORD46 HSD11B1L ILF3 WRNIP1 TUT1 KHK ADRM1 CRELD1 DNASE1 PAICS TRIM28 DRAP1 MRPL14 NOP56 AFMID METTL2A POFUT2 POLR3E ILF2 NOB1 SYCE2 SPHK2 SAP130 PIAS4 SAP30BP DIDO1 RAB24 CIC TPD52L2 TBCD PHF23 MEX3D EIF3A RAD23A RBM42 GPAM ZNF865 CDC34 MRPL36 ZNF653 CBX1 NCSTN MIS18A MMS19 CNOT11 PIGT MED9 CYB561D2 HAGH RABIF MEF2D FSTL4 IRF2BPL YPEL1 CNNM4 ISG15 DHTKD1 SLC52A2 MLF2 PLEKHH3 PIGM DDX42 BAG3 FAM220A DDA1 TMEM222 PRMT5 RAD9A ZSWIM3 TYW1 PPFIA3 TGIF2 PAF1 HMGB3P22 SNORA37 XRCC1 ANKRD11 LYSMD1 LRWD1 IMPDH2 GRHL1 PAOX ZNF79 CHMP2A TRAPPC1 IPO4 POP7 ULK1 GTF3C1 PA2G4 RER1 LPIN2 MAP2K7 PLOD3 SNRNP70 SDHA TMUB2 REXO1 GNB1L ARPC1A ZFAND2B FRS3 TMEM201 MVB12A INO80B RNU5B-1 TSPAN31 KIF15 NOLC1 MBD1 NDUFV3 ZNF554 GAA TPR ZNF3 KLHL22 PDRG1 PEX10 RPL37A PMM1 ARF1 NPRL2 ALKBH6 DLGAP4 LRRC59 DCAKD HNRNPU ZWINT GATAD2A NFRKB CSK TBC1D17 HINFP NCAPG2 FANCA CCDC87 CCNL2 GDPGP1 TRMT44 SCAP RNASEH1 R3HDM2 GBA PPP1R12C PPIF EIF5A CPNE1 ANLN PAK1IP1 COPA ZNF217 PGS1 CASP2 PRELID1 CKAP2L EDEM2 CABIN1 AKAP1 IER5 RAB3A RPL36 CDC6 CCDC97 TOM1 DFFA GPI ZNF784 RPS16 TMEM160 KXD1 CDK11B CNTROB TMEM41A MRPS33 TOP1 ERP29 ARMC5 ARMC7 NUF2 BCKDHA LIMD2 ZNF775 MAPK8IP3 SEC61A1 C11orf24 GTF3A OSBP2 NUDCD3 ZDHHC4 UBALD2 RBM47 STK40 STAT1 GEMIN2 PPAT PUS7 ELMOD3 ZNHIT2 BCL9 MRPL17 HNRNPM DAGLB LARS2 ATP6V1E2 RPL27 VPS51 POLH RNF145 YEATS4 ZXDC C12orf65 C1orf74 HM13 NISCH TTC1 ZBED4 MAP4K1 TMEM91 TPCN2 WDR81 SUPT7L GDF15 FAM193A DDX19A DEDD2 DCAF13 NUMA1 ZFP69B C19orf73 GLCCI1 SKA3 PCGF3 DSN1 SNAI3-AS1 PLCB3 TEX264 PPCDC RAD23B FAM177A1 PSMD8 RANBP3 RPL22L1 DALRD3 PARN WNT10A MRPL44 DTD1 MED29 HES4 HOMEZ DLEU1 TRAPPC3 SAE1 CUEDC1 SEC23B BSG MGMT SLC3A2 TOLLIP TBC1D10A USP22 NUP188 MAFA XPOT NUB1 SIX5 FBXL6 KIF18A ITGAE RALGDS CINP RFT1 DSCC1 HNRNPL UQCC1 MATN1-AS1 SAFB HSPA8 MTHFSD BOP1 GAK SH3GL1 SMG9 FAHD1 SUGP2 PRPF31 WDR59 MIF4GD SPDL1 CCDC47 SLC1A5 CIB1 ACOX3 AP2A2 UBTD1 OPA3 PGAP2 MCM3 GNB2 STX6 TBCA GTSE1 MFN2 MAD2L1 MIR4512 AHCYL2 CHD2 LIPE ADPRHL2 CANX MCM8 TTLL12 MORN1 down
## CDC73_TARGET_GENES 0.0020704 0.0047852 -0.4401000 -2.431534 0 538 ASB16 PABPC1L SAMD10 MBD6 P4HB MROH6 CDK5RAP3 C7orf50 SLC14A2 B4GALT7 ANKRD13D PRPF6 CYC1 SLC2A4RG ATXN2L CUL9 MGAT4B PPP1R27 WDR6 PITPNM1 TSEN54 NADK NCL ASB6 RECQL5 TIMM50 NDUFV1 DECR2 TMEM86B SNORD15B HSPB1 HAX1 SAMD4B DUSP23 ATG4D TLE6 MCM3AP ING5 TRABD SNHG7 EDC4 GAS5 ATP6V0E2 MST1P2 MAD1L1 MPHOSPH10 EHMT1 FASN ACBD4 TRIM41 PPP6R1 TP53 U2AF2 RPL37 DPP9 KDM2A ATP2A1 CROCCP2 PRR7 TOMM40 SLC35B2 CICP14 PABPC1 C1orf56 ECI1 PPP4C SNORA14B NUP62 AP5S1 CDCA5 LASP1 MRPS15 SNRPE POLM PABPN1 HDAC10 TUT1 NBEAL2 GTF3C5 ADRM1 GRWD1 SRCIN1 MAZ POLR3E DPP7 ILF2 TRIM65 RAD23A ITGA3 FBXO6 SMARCC2 TSC2 ARFRP1 GPT DNASE1L2 LINC00680 CLPB MRPS26 RHBDF2 MED16 THTPA TCIRG1 IGLV1-51 EPOR RPPH1 SLC35E1 TMEM222 SUMF2 GNL3 SCAND1 IMPDH2 IPO4 RN7SL521P NEK6 EPN1 FIS1 ZNF839 TUBGCP6 PSMB3 STRN4 REXO1 MUS81 FRS3 COL9A2 TPR YBEY TMEM179B MYBPH FLT3LG EXOSC6 HNRNPU ZNF398 PLEKHG2 MSTO1 CSK C19orf81 DIAPH1 CERS2 NEK8 GNG13 IER5 ZNF425 TRPC4AP DHPS DVL2 NUF2 DMAP1 LIMD2 MAPK8IP3 TBL1X KDM3B PTMA MIRLET7I MAP7 HAGHL PFDN4 ARHGEF16 SBNO2 PIN1 AGO2 RBBP5 GAPDH NLRX1 EBPL ASCC2 FUS EML3 DDX11L10 SEZ6 ZFP69B NCBP2 MIR4519 SNHG8 RHOF TAF1C DALRD3 BAHCC1 DLEU1 BCKDK SLC3A2 SNORD72 SCARNA2 GPS2 ZFHX2 MAFA RPL31 RPL27A HES6 NDUFS3 CDK9 C11orf72 CIRBP-AS1 CLK3 ZFAS1 MTBP KDELR1 CCDC58 B3GALNT2 KAT5 MIF4GD PDE4A IL4I1 ENPP3 SLC16A3 NANOS1 SMURF2P1 MIR4512 RNU6-9 MAN2A2 NCKIPSD NDUFS7 SMIM4 LRRC41 TTLL12 SMG7 CTPS1 MZF1 SNORA13 ATF5 CREB3 ADNP DUS2 MPPE1 RMRP WRAP53 C15orf48 CYP2E1 COG2 TSSC4 ALOXE3 CIRBP ACLY MIAT RPS7 ADAT1 PARP2 HSF1 EPHB3 ACTB UQCR11 SNRPD1 GOLGA5 DDX11L5 CRNDE TRGV4 ABCA17P SATB2 NACA ANKRD46 MLX POP5 down
## MIR1250_3P 0.0019881 0.0047852 0.4444450 2.430966 0 464 FAT3 PTGFR VIT TCTEX1D1 PDS5B ATXN3 SNTB2 SLC6A4 RAB8B MYCT1 BMPR2 ZEB2 CACNB4 SLC38A2 SPATA6 VGLL3 AKT3 PDCD6IP CALM1 SEMA5A EFEMP1 PTPRB VAMP4 KIAA1324L CHURC1 PAFAH1B1 RBMS3 INSIG1 DGKE FEM1B ATG2B RAB11A ADRA1A GPM6B CHD9 TM4SF18 HMBOX1 PTPN21 QKI SLC18A2 CENPC PKIA RSBN1 OGFRL1 SGCD DICER1 LGALSL TMOD2 APBB2 LAMTOR3 MYRIP LPCAT2 STXBP5 CPEB3 GABPA DOK6 ZNF326 GRAMD1C PGAP1 PICALM FFAR4 PLG AKAP11 CDK6 SDC2 KCNA4 NPY1R GUCY1A2 ARHGAP29 CA5B OMA1 TNKS OSBPL8 TTC7B BTBD10 CCDC82 MYOZ1 CLDN16 DAAM1 SGIP1 LBH BICC1 SMAD6 LPL LACC1 ATL3 PCDH10 SCAI RAB11FIP2 SOX6 SCARA3 PHIP PAN3 IQGAP2 RHOQ NTRK2 LRRFIP1 CREB1 CDC14A YBX3 KIAA0040 NFASC MFAP3L NAP1L3 RNF138 RAB33B ZMAT3 DNAJC27 PKDCC RIOK3 KIAA1549L LIMS1 MBNL3 PCDH17 GPR34 TMTC1 CALD1 LIPA ARMC3 MEOX1 ZFAND6 IGF1 C5orf24 PNISR SPOPL TBC1D4 CNTN4 SNX2 CHIC1 TMF1 SS18 STON2 TFRC CACHD1 BMP2K ERBB4 FAM102B ONECUT2 RMND5A FUBP1 EBF2 MAP3K2 MOB1A CNOT4 ZC3H6 ZDHHC20 PUM2 SLC10A2 ATP6V1B2 ARL3 ISCA1 PLCXD3 CHMP2B B3GNT5 MYCBP2 SLC4A4 C8orf34 AGPAT5 SLC36A4 LMO4 ATE1 KLF12 TNPO1 ZKSCAN1 ZNF704 CCNC EXOC5 MOB1B GPCPD1 MMAA FAM171B PCMTD1 SMCHD1 IL17RD GNAI1 AAK1 GNG2 DIO1 RLIM TGFBR1 CTNNA3 SPCS3 DNAJA4 KPNA4 FBXO48 TMEM135 KLHL15 PDE1A ALDH1A2 FRMPD4 SMAD5 RCAN2 HNRNPR TEAD1 FKBP1A KRT6C COBLL1 up
## MIR200C_3P 0.0019920 0.0047852 0.4416113 2.414921 0 465 FAT3 RTKN2 SEMA6D CPED1 GPM6A DACH1 FHL1 ARHGAP6 TRHDE PDS5B IGSF10 SLIT2 RECK SESN1 EVI5 MBNL2 NAP1L5 ADH1B CASR REEP1 CTDSPL2 ALDH1A1 GNAQ ZEB2 NTF3 FOXF1 CLIC4 TMOD3 SERINC1 NR5A2 ERG HIPK3 CHN2 FSD1L POLK LEPR KLF4 PRKG1 LIN7A DGKH PSIP1 ZEB1 HMBOX1 PTPN21 QKI PTPN12 PKIA FERMT2 SLC14A1 RDX AP1S2 HECTD2 FLI1 NFIA MAP4K5 BNC2 CHRDL1 RBFOX2 B3GNT2 KIAA0355 ZNF326 FAM227B MYZAP PICALM ZYG11B SDC2 SLC24A4 YPEL2 KLF6 HS2ST1 AKAP7 CORO1C MPDZ ADIPOR2 TIMP2 FAM118B OSBPL11 ZCCHC24 CLASP2 CDK17 CCDC82 FIGN SGIP1 BICC1 NOVA2 KANK2 ULK2 SCAI DZIP1 RAB11FIP2 TRAPPC8 ASAP1 MAP4K3 HIPK1 FOXN2 DIXDC1 LOX PLCL1 ELK3 NTRK2 CNEP1R1 NAB1 RUSC2 DENND5A MYB ROCK2 NUDT4 JAKMIP2 CRTAP ZMAT3 CFL2 CEP85L TRIM33 OTUD4 SLC30A7 ADAMTS3 PROK2 SCAMP1 FRMD6 SNX16 VAT1L SGCE SLC25A36 EXOG MBNL3 RGL1 ZFAND6 SLC39A14 GAS2L3 ZFPM2 ITGA1 DTNA FAM8A1 STRN TBC1D12 NRG1 CSNK1G3 CHSY1 WASF3 PIK3CA SECISBP2L FSTL1 TRIM23 ZKSCAN8 PRKACB SUSD5 PTAR1 ARL2BP SYDE1 ZC3H6 RND3 JUN PUM2 TLN2 KYNU OSTM1 SBSPON RASSF8 COPS8 AGFG1 JAZF1 SPAG9 CSMD3 PTPRZ1 TBX18 SLC1A2 C11orf87 FOXG1 SLC35B4 CBL ESRRG PCMTD1 PPM1F VLDLR PIKFYVE ETS1 SRGAP1 ARL5A RANBP10 CCNYL1 GJC1 ARIH1 SYNJ1 MFAP5 DPH6 FBXO30 CNTN1 CNKSR3 ZFX ATXN1 MIB1 MCFD2 TMX4 MAP4K4 PPP4R2 RASA2 up
fgsea_plot(fgsea_res$res_c4, pathways_title='C4 cancer', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------ ---------- --------- ----------- ---------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## MORF_CSNK2B 0.0019763 0.006136 -0.6183210 -3.159937 0 258 SLC4A2 SNRNP200 NDUFS8 EIF3B PDCD6 DAP3 HDGF TBL3 SEC24C CTBP1 PPM1G TMED9 AP3D1 EIF4G1 CYC1 UBAP2L CCT3 CHD4 PDAP1 LARP1 NDUFV1 MAEA ATIC CCT7 NHP2 LSM4 EIF2B4 GPX4 LMNB2 CCT5 HAX1 JTB CBX3 NDUFS2 RALY MCM7 TUFM RNPEP CDK4 MAP2K2 SF3B2 DCTN2 PPP1CA PTOV1 HSPD1 MRPL9 FEN1 CHERP DAP CCT2 TMEM147 SNRPE SNRPA ILF3 EIF3C TRIM28 IMPDH1 COX6C COPE BANF1 RAD23A NONO ARHGDIA HNRNPAB HNRNPUL1 GGCT FBL FIBP COMMD4 SF3A2 PSMB4 SEC13 RER1 NDUFS5 GANAB SDHA CS ESPL1 ANP32B C1QBP RUVBL2 PRMT1 DHCR7 NDUFAB1 MPV17 DDX49 GPI KXD1 ERP29 COX6B1 PUF60 POLR2I PRRC2C HSPA9 FUS SMARCD2 PSMD9 SOD1 TECR RAD23B PSMD8 PPP2R1A DDOST RBM14 CLTA TRAPPC3 SLC3A2 SF3A1 NDUFS3 KDELR1 PRPF31 SLC1A5 CLPP COX4I1 GNB2 UQCRFS1 CANX MTDH HUWE1 SMG7 UQCRC1 EIF3K RHEB COPS5 URM1 BZW1 EIF3I CTDNEP1 ALG8 EIF4E2 PSMB2 PSMB7 ACLY HNRNPA2B1 PARK7 XRCC6 SNRPD2 COX5B SET UQCRH down
## MODULE_54 0.0019685 0.006136 -0.6007418 -3.057640 0 241 RECQL4 MAPK13 DTYMK MYBL2 TIMELESS RANBP1 WDR5 UBE2C RCC1 TUBA4A POLD1 UBE2T E2F1 NEIL3 PKMYT1 LMNB2 CCT5 ODC1 MCM7 NUDT1 HMGA1 HJURP CDK4 ASF1B AHCY TACC3 CDC25B AIMP2 CHAF1A AURKB MCM2 FEN1 CCT6A ZC3HC1 BIRC5 CDCA5 DDX11 CCNF SNRPE NME1 WIZ SRPK1 MCM4 NT5DC2 CHAF1B TPX2 UBE2S FOXM1 PTTG1 CDC20 NQO1 PLK1 CCNB1 CEP55 MKI67 KIF2C BYSL TROAP LRP8 BUB1 APEX2 LAPTM4B GGT1 PRDX4 RRM2 NEK2 ATAD2 AURKA ZWINT SNRPC OAS3 ORC1 LMNB1 TOP2A CDH1 ANLN CENPF SMC4 KIF14 POLQ CDC6 PFKP SLC7A5 KIAA0100 NUF2 MELK TNFRSF12A SCG5 HMMR PSPH RAD54L NCAPH PRR11 NDC80 SPAG5 PMAIP1 PLAT ASPM DHFR NCAPD2 CENPA CDC25C MCM5 CENPE SHCBP1 DLEU1 HMGB2 APOBEC3B CCNA2 CKAP2 GINS1 MUCL1 RFC4 RHNO1 SNRPF KIF11 GPN2 CDKN3 MCM3 SLC16A3 MAD2L1 IMPA2 ETV2 DLGAP5 HUWE1 CTPS1 KNTC1 ATF5 BEST3 FAM217B CDK1 BUB1B CCNE2 PIR TTK PLK4 PLP2 down
## MORF_FBL 0.0019531 0.006136 -0.6504998 -3.046449 0 129 EIF3B HDGF TBL3 PPM1G CYC1 CCT3 PDAP1 NCL NDUFV1 CCT7 LSM7 LSM4 JTB CBX3 RALY MCM7 NUDT1 HSP90AB1 TUFM AHCY UBE2I HSPD1 AURKB MRPL9 MCM2 CCT2 TMEM147 SNRPE SNRPA NME1 ILF3 EIF3C RNPS1 TRIM28 ILF2 BANF1 RAD23A NONO HNRNPAB HNRNPA1 HNRNPUL1 FBL FIBP SF3A2 IMPDH2 EIF3G CS ANP32B C1QBP RUVBL2 PRMT1 DDX49 GPI KXD1 PUF60 POLR2I FUS SOD1 PSMD8 PPP2R1A DDOST NDUFS3 UQCRFS1 RSL1D1 RPL14 EIF3K EIF3I PSMB2 PSMB7 HNRNPA2B1 PARK7 XRCC6 SNRPD2 SET UQCRH RPL10A down
## MORF_PHB 0.0019120 0.006136 -0.6492842 -2.996956 0 113 B4GALT3 CSNK1D CAD MRPL28 TSTA3 TFAP4 PSD4 SRRT SPRN PSMD3 MTX1 WDR18 BMS1 NELFB EIF6 WDR62 CPSF4 PKMYT1 PSMD2 OTUB1 AATF ERAL1 PRKCSH RABGGTA SH2B1 ADAM15 DRG2 NUP62 DDX11 FANCG GRK6 PABPN1 IGSF9B ILF2 TOMM34 BAHD1 FDXR PCGF1 BPHL CNPPD1 HMG20B PSMB6 POLR2A CHD3 CS ILVBL TPR NFRKB PHB COPS6 BRD3 MCRS1 MEA1 MLEC TUBGCP2 NAP1L4 EML3 MPST CDC25C PCGF2 PARN NUP188 HNRNPL RPRD2 CCT4 CIB1 MFN2 XPO6 PLIN3 TCOF1 GNL2 SFSWAP down
## MORF_BUB3 0.0019342 0.006136 -0.5823501 -2.969230 0 243 SNRNP200 DAP3 SEC24C PPM1G TMED9 CYC1 CAD UBAP2L CCT3 NCL THOP1 NDUFV1 CCT7 LSM7 LSM4 SSRP1 LMNB2 CCT5 HAX1 AK2 SRM EDC4 CBX3 NDUFS2 MCM7 NUDT1 TUFM RNPEP AATF CHAF1A MAP2K2 RANGAP1 SF3B2 PDIA6 AURKB MRPL9 MCM2 FEN1 DNMT1 CHERP NUDC BRD8 CCT2 SNRPE SNRPA ILF3 PAICS TRIM28 IMPDH1 ILF2 UBE2S RAD23A NONO HNRNPAB HNRNPUL1 KHSRP FBL FIBP SF3A2 IMPDH2 BUB1 TXNL4A NDUFS5 GANAB SDHA CS ESPL1 ANP32B HNRNPU ZWINT CSK RUVBL2 DNAJC11 PRKDC DDX49 AHSA1 KXD1 ERP29 POLR2I SLBP HNRNPM HSPA9 FUS SOD1 TFDP1 NCBP2 PSMD8 MCM5 PPP2R1A DDOST TRAPPC3 NUP188 XPOT NDUFS3 ANP32A SAFB GOT2 RFC4 PRPF31 SLC1A5 CLPP MCM3 RSL1D1 MTDH UQCRC1 EIF3K RHEB COPS5 STMN1 EIF3I CTDNEP1 PSMB2 MRPS27 ACTL6A PSMB7 ACLY HNRNPA2B1 PARK7 XRCC6 SET MCM6 UQCRH down
## MORF_ANP32B 0.0019802 0.006136 -0.6014110 -2.942362 0 183 EEF1D SNRNP200 HDGF CTBP1 PPM1G CYC1 CHD4 PDAP1 NCL NDUFV1 SART1 CCT7 LSM7 JTB CBX3 RALY MCM7 NUDT1 HSP90AB1 TUFM UBE2I SF3B2 PPP1CA HSPD1 AURKB MRPL9 PABPC1 CCT2 SNRPE SNRPA GNAS ILF3 EIF3C RNPS1 TRIM28 COPE BANF1 RAD23A NONO HNRNPAB HNRNPA1 HNRNPUL1 FBL COMMD4 SF3A2 PTBP1 PSMB4 EIF3G GANAB SDHA ANP32B SSR2 DDX49 NDUFA1 KXD1 ERP29 COX6B1 COPS6 PUF60 TAF7 RPL30 RPS24 FUS SMARCD2 SOD1 RPL36AL PSMD8 RPS6 PPP2R1A DDOST TATDN2 HMGB2 RPLP2 SF3A1 NDUFS3 COX4I1 GNB2 UQCRFS1 EIF3H RSL1D1 CANX MTDH RPL14 RPL7 EIF3K COPS5 URM1 EEF2 COX7C PSMB7 PARK7 XRCC6 SNRPD2 COX5B SET UQCRH down
## MORF_MAP2K2 0.0019380 0.006136 -0.6348342 -2.937086 0 117 SLC4A2 SNRNP200 TBL3 PPM1G TMED9 AP3D1 CYC1 NDUFV1 CCT7 LSM4 GPX4 CCT5 HAX1 JTB TUFM RNPEP MAP2K2 RANGAP1 SF3B2 DCTN2 MRPL9 TMEM147 SNRPE SNRPA TRIM28 IMPDH1 COPE UBE2S BANF1 RAD23A NONO HNRNPAB HNRNPUL1 FIBP NDUFS5 GANAB SDHA CS RUVBL2 DDX49 GPI KXD1 ERP29 PUF60 POLR2I SOD1 DGKZ PSMD8 PPP2R1A DDOST TRAPPC3 RPN1 SLC3A2 NUP188 NDUFS3 PRPF31 GNB2 CANX MTDH EIF3K RHEB COPS5 EIF3I CTDNEP1 PSMB2 PSMB7 PARK7 COX5B SET down
## GNF2_CCNA2 0.0019841 0.006136 -0.7084381 -2.922673 0 65 UBE2C MCM7 HJURP ASF1B AURKB MCM2 FEN1 CDCA8 BIRC5 KIF18B MCM4 TPX2 FOXM1 CDC20 PLK1 MKI67 KIF20A RRM2 ESPL1 AURKA ZWINT TOP2A CENPF SMC4 KIF4A KIF14 MELK HMMR NDC80 ASPM NCAPD2 CENPA CENPE EZH2 SHCBP1 HMGB2 CCNA2 PRC1 RFC4 KIF11 MCM3 DLGAP5 CDK1 BUB1B TTK NUSAP1 RACGAP1 MCM6 GMNN down
## MORF_RAN 0.0020000 0.006136 -0.5754452 -2.920409 0 239 EEF1D SNRNP200 PDCD6 DAP3 HDGF CTBP1 PPM1G CYC1 CCT3 PDAP1 NCL NDUFV1 POLR2H MYL6B CCT7 HAX1 JTB NIPSNAP1 CBX3 RALY HSP90AB1 TUFM UBE2I DCTN2 PPP1CA HSPD1 MRPL9 PABPC1 CCT2 TMEM147 SNRPE SNRPA GNAS NME1 EIF3C MRPS12 RNPS1 TRIM28 RPS10 COX6C ILF2 COPE BANF1 RAD23A NONO HNRNPAB HNRNPUL1 PSMB6 FBL FIBP COMMD4 PTBP1 PSMB4 NDUFS5 RPN2 PPIA GANAB PSMB3 SDHA CS FDPS ANP32B SSR2 C1QBP RUVBL2 PRMT1 MRPL23 NDUFAB1 DDX49 GPI NDUFA1 KXD1 ERP29 COX6B1 COPS6 PUF60 RPL11 POLR2I RPL30 RPS24 FUS SMARCD2 SOD1 RPL36AL PSMD8 RPS6 PPP2R1A CLTA RPLP2 NDUFS3 HSPA8 COX4I1 UQCRFS1 EIF3H RPL13 CANX MTDH RPL14 HUWE1 STOML2 RPL7 EIF3K RHEB COPS5 EEF2 CTDNEP1 COX7C PSMB2 PSMB7 ACLY HNRNPA2B1 PARK7 XRCC6 SNRPD2 COX5B SET UQCRH down
## GNF2_CENPF 0.0019685 0.006136 -0.7223847 -2.899659 0 58 DTYMK MYBL2 UBE2C MCM7 HJURP MCM2 FEN1 CDCA8 BIRC5 CCNF KIF18B MCM10 TPX2 UBE2S FOXM1 PTTG1 CDC20 MKI67 RRM2 KIF15 AURKA ZWINT TOP2A CENPF SMC4 KIF4A HMMR NDC80 ASPM CENPE SHCBP1 HMGB2 CCNA2 CKAP2 PRC1 RFC4 KIF11 MCM3 DLGAP5 CDK1 TTK PLK4 NUSAP1 down
## GNF2_PCNA 0.0019841 0.006136 -0.7020765 -2.896428 0 65 MYBL2 MCM7 MCM2 FEN1 CDCA8 BIRC5 PAXIP1 KIF18B MCM4 TPX2 FOXM1 HNRNPAB CDC20 MKI67 PA2G4 RRM2 KIF15 ESPL1 AURKA ZWINT TOP2A CENPF SMC4 MELK HMMR RAD54L SLBP NDC80 ASPM MCM5 CENPE SHCBP1 HMGB2 CCNA2 PRC1 GINS1 RFC4 KIF11 MCM3 DLGAP5 CDK1 BUB1B TTK PLK4 NUSAP1 RACGAP1 MCM6 GMNN down
## GNF2_CDC20 0.0019881 0.006136 -0.7275710 -2.885765 0 53 UBE2C AURKB MCM2 CDCA8 BIRC5 KIF18B MCM4 TPX2 UBE2S FOXM1 PTTG1 CDC20 PLK1 MKI67 KIF2C BUB1 KIF20A RRM2 ESPL1 AURKA ZWINT TOP2A CENPF SMC4 KIF4A MELK HMMR NCAPH NDC80 SPAG5 ASPM CENPE SHCBP1 CCNA2 PRC1 KIF11 DLGAP5 CDK1 BUB1B TTK PLK4 NUSAP1 RACGAP1 down
## MORF_DAP3 0.0019881 0.006136 -0.5904428 -2.885733 0 179 SNRNP200 ALG3 DAP3 TBL3 CTBP1 CYC1 CCT3 PDAP1 NCL EIF2B5 NDUFV1 POLR2H NELFB EIF6 CCT7 EIF2B4 HAX1 JTB NIPSNAP1 PSMD2 CBX3 RALY HSP90AB1 TUFM AATF UBE2I HSPD1 MRPL9 BRD8 CCT2 TMEM147 SNRPE SNRPA IMPDH1 ILF2 BANF1 NONO SMARCC2 HNRNPAB HNRNPUL1 PSMB6 FIBP PSMB4 RPN2 GANAB PSMB3 SDHA CS TBCB FDPS SSR2 RUVBL2 MRPL23 DDX49 KXD1 COX6B1 COPS6 BRD3 PUF60 POLR2I PIN1 NAP1L4 NCBP2 PSMD8 PPP2R1A DDOST TRAPPC3 NUP188 RPP40 NDUFS3 HSPA8 COX4I1 DNPEP ZNF146 CANX ARFGAP2 HUWE1 STOML2 EIF3K RHEB COPS5 EIF3I CTDNEP1 COX7C PSMB2 PSMB7 ACLY HNRNPA2B1 PARK7 COX5B SET UQCRH DGUOK SDR39U1 POP5 SNRPB DDB1 AFG3L2 down
## MORF_SOD1 0.0019531 0.006136 -0.5645612 -2.885701 0 247 SLC4A2 SNRNP200 NDUFS8 EIF3B PDCD6 TBL3 PPM1G CYC1 UBAP2L CCT3 LARP1 NDUFV1 ATIC CCT7 NHP2 LSM4 EIF2B4 CCT5 HAX1 CBX3 NDUFS2 TUFM CDK4 AIMP2 MAP2K2 ENSA SF3B2 DCTN2 PPP1CA HSPD1 MRPL9 FEN1 CHERP DAP NUDC CCT2 TMEM147 SNRPE SNRPA NME1 ILF3 EIF3C TRIM28 COX6C ILF2 BANF1 RAD23A NONO HNRNPAB CCNB1 PSMB6 GGCT FBL FIBP PSMB4 SEC13 NDUFS5 ATOX1 GANAB SDHA PRDX4 CS FDPS ANP32B C1QBP HNRNPU RUVBL2 PRMT1 NDUFAB1 MPV17 DDX49 AHSA1 KXD1 PUF60 POLR2I C6orf62 HSPA9 FUS SMARCD2 PSMD9 SOD1 TECR MAML1 RAD23B PSMD8 PPP2R1A TRAPPC3 SLC3A2 XPOT SEC61G NDUFS3 MRPL3 HSPA8 PRPF31 COX4I1 TBCA CANX MTDH HUWE1 SMG7 STOML2 RHEB COPS5 BZW1 EIF3I CTDNEP1 ALG8 EIF4E2 PSMB2 HSPA4 PSMB7 ACLY HNRNPA2B1 PARK7 SET UQCRH down
## GNF2_CDC2 0.0019608 0.006136 -0.7128479 -2.882080 0 59 MYBL2 UBE2C HJURP MCM2 FEN1 CDCA8 BIRC5 CCNF KIF18B TPX2 UBE2S FOXM1 PTTG1 CDC20 MKI67 KIF20A RRM2 KIF15 AURKA ZWINT TOP2A CENPF SMC4 KIF4A MELK HMMR NDC80 ASPM CENPE EZH2 SHCBP1 HMGB2 CCNA2 CKAP2 PRC1 RFC4 KIF11 DLGAP5 CDK1 TTK PLK4 NUSAP1 down
## MORF_PPP1CA 0.0020325 0.006136 -0.6020975 -2.877017 0 153 EEF1D PDCD6 HDGF CTBP1 PPM1G CYC1 UBAP2L PDAP1 NDUFV1 ATIC CCT7 JTB CBX3 RALY TUFM HARS2 ENSA SF3B2 DCTN2 PPP1CA HSPD1 MRPL9 DAP ARPC1B CCT2 TMEM147 SNRPE EIF3C TRIM28 COX6C COPE BANF1 NONO PSMC3 ARHGDIA HNRNPAB HNRNPUL1 GGCT FIBP PSMB4 RER1 GANAB ANP32B SSR2 PRMT1 C9orf16 DDX49 NDUFA1 ERP29 COX6B1 PUF60 VCP POLR2I AP1B1 SMARCD2 PSMD9 SOD1 TECR RAD23B RPL36AL PSMD8 PPP2R1A CLTA NDUFS3 CDIPT ARF5 COX4I1 TBCA DNPEP CANX MTDH SMG7 STOML2 EIF3K COPS5 URM1 EIF4E2 PSMB2 BUD31 PARK7 SNRPD2 COX5B SET down
## MORF_DDB1 0.0019646 0.006136 -0.5705538 -2.875986 0 226 SLC4A2 SNRNP200 B4GALT3 ALG3 FOXK2 DAP3 CSNK1D CAD MRPL28 TSTA3 TFAP4 ATXN2L ERCC2 BECN1 SRRT PDAP1 SPRN PSMD3 MTX1 EIF2B5 WDR18 TTI1 BMS1 PDIA4 NELFB GOLGA3 EIF6 WDR62 CPSF4 PKMYT1 SSRP1 PSMD2 OTUB1 AATF DNPH1 PRKCSH RABGGTA SH2B1 MCM2 PEX6 ADAM15 BRD8 NUP62 DDX11 FANCG TRRAP ATG9A DRAP1 ILF2 TOMM34 BAHD1 FDXR NONO SMARCC2 HNRNPAB PCGF1 BPHL MMS19 PSMB6 CSNK1G2 POLR2A NCOR2 SGTA SDHA PRDX4 TMED1 CHD3 CS ILVBL TPR DDX39A YIF1A NFRKB PHB RUVBL2 PRKDC KXD1 TXLNA COPS6 BRD3 PUF60 KDM3B MEA1 PIN1 MLEC DDX46 TUBGCP2 NAP1L4 EML3 MPST NCBP2 CDC25C PCGF2 RANBP3 PARN NUP188 HNRNPL RPRD2 HSPA8 CCT4 PRPF31 CIB1 MFN2 CANX HUWE1 XPO6 PRPF4 PLIN3 TCOF1 GNL2 CTDNEP1 SFSWAP UBE3C ACTL6A KAT2A HNRNPA2B1 PARP2 SLC25A11 CLTC down
## GNF2_CCNB2 0.0019608 0.006136 -0.7233790 -2.875798 0 54 UBE2C MCM2 FEN1 CDCA8 BIRC5 KIF18B MCM4 TPX2 UBE2S FOXM1 PTTG1 CDC20 KIF2C BUB1 KIF20A RRM2 ESPL1 AURKA ZWINT TOP2A CENPF SMC4 KIF4A MELK HMMR NCAPH NDC80 SPAG5 ASPM CENPE SHCBP1 HMGB2 CCNA2 CKAP2 PRC1 RFC4 KIF11 DLGAP5 CDK1 BUB1B TTK PLK4 NUSAP1 RACGAP1 down
## MORF_GPX4 0.0019646 0.006136 -0.7301618 -2.868156 0 50 EEF1D FASTK TMED9 CYC1 PDAP1 NDUFV1 GPX4 JTB RALY MAP2K2 DAP TMEM147 COPE BANF1 PSMB4 RER1 GANAB SSR2 C9orf16 KXD1 COX6B1 TECR PSMD8 PPP2R1A DDOST CLTA TRAPPC3 WBP2 KDELR1 ARF5 GNB2 CANX RHEB COPS5 PSMB2 down
## MORF_RAD23A 0.0019881 0.006136 -0.5508380 -2.867035 0 304 NPM3 SNRNP200 NDUFS8 EIF3B CIAO1 HDGF TBL3 SEC24C CTBP1 PPM1G TMED9 AP3D1 CYC1 CAD UBAP2L CHD4 FARSA NCL LARP1 THOP1 NDUFV1 CCT7 LSM4 LMNB2 CCT5 HAX1 AK2 JTB DEAF1 EDC4 CBX3 NDUFS2 NUDT1 TUFM RNPEP AATF RNF126 MAP2K2 SF3B2 PDIA6 MRPL9 MCM2 DNMT1 CHERP NUDC MGRN1 CCT2 SNRPE SNRPA ILF3 PABPN1 MRPS12 RNPS1 TRIM28 IMPDH1 ILF2 COPE RAD23A NONO HNRNPAB HNRNPUL1 KHSRP FBL SMARCC1 FIBP SF3A2 POLR2A RPIA CHMP2A TXNL4A NDUFS5 GANAB SDHA CS ESPL1 ANP32B DHX38 DDX39A HNRNPU ZWINT CSK RUVBL2 DNAJC11 DHCR7 DIAPH1 PPIF PRKDC DDX49 AHSA1 KXD1 ERP29 PUF60 POLR2I SLBP PRRC2C HNRNPM PKN1 TTC1 HSPA9 FUS SMARCD2 DDX19A SOD1 TFDP1 DGKZ PPP2R1A DDOST CLTA TRAPPC3 RPN1 SLC3A2 NUP188 XPOT SF3A1 NDUFS3 ANP32A NDUFA7 SAFB GOT2 RFC4 PRPF31 SLC1A5 CLPP MCM3 GNB2 UQCRFS1 EIF3H RSL1D1 CANX MTDH UQCRC1 EIF3K RHEB COPS5 BZW1 EIF3I CTDNEP1 PSMB2 PSMB7 ACLY HNRNPA2B1 PARK7 XRCC6 SET MCM6 UQCRH down
## MORF_AATF 0.0019342 0.006136 -0.5787556 -2.862922 0 191 SNRNP200 ALG3 DAP3 CYC1 CAD TFAP4 SRRT NCL PSMD3 MTX1 EIF2B5 THOP1 WDR18 BMS1 NELFB EIF6 LSM7 PKMYT1 SSRP1 PSMD2 RALY TUFM RUVBL1 AATF AIMP2 PRKCSH UBE2I MRPL9 MCM2 NUDC BRD8 CCT2 NUP62 TRRAP SNRPA PABPN1 RNPS1 ILF2 RAD23A NONO SMARCC2 HNRNPAB MMS19 CNPPD1 PSMB6 FIBP POLR2A SGTA PSMB3 SDHA CS DHX38 DDX39A HNRNPU CSK PHB RUVBL2 DNAJC11 PRKDC DDX49 AHSA1 KXD1 TXLNA COPS6 PUF60 KDM3B POLR2I MTOR PIN1 MLEC FUS NAP1L4 MCM5 TRAPPC3 RPN1 NUP188 SAFB HSPA8 CCT4 PRPF31 COQ9 MFN2 CANX ARFGAP2 HUWE1 XPO6 EIF3K COPS5 TCOF1 GNL2 EIF3I CTDNEP1 SFSWAP ACTL6A PSMB7 KAT2A ACLY HNRNPA2B1 TIMM17A down
## MORF_EIF3S2 0.0020000 0.006136 -0.5708779 -2.855966 0 220 SLC4A2 NPM3 SNRNP200 ALG3 CIAO1 DAP3 TBL3 PPM1G CYC1 CAD NCL THOP1 NDUFV1 WDR18 CCT7 LSM7 LSM4 PKMYT1 SSRP1 AK2 DEAF1 SRM PSMD2 CBX3 NDUFS2 LDHB NUDT1 TUFM RNPEP AATF UBE2I CHAF1A MAP2K2 PDIA6 MRPL9 MCM2 DNMT1 NUDC BRD8 CCT2 SNRPE SNRPA ILF3 PABPN1 RNPS1 IMPDH1 ILF2 RAD23A NONO HNRNPAB FBL HSP90B1 FIBP SF3A2 POLR2A IMPDH2 RPIA TXNL4A NDUFS5 GANAB CS CSK RUVBL2 PRKDC DDX49 GPI KXD1 TXLNA RAD54L POLR2I PIN1 MLEC FUS NAP1L4 SOD1 PPP2R1A DDOST RPN1 SLC3A2 NUP188 NDUFA7 SAFB RFC4 CCT4 PRPF31 CLPP COQ9 GNB2 UQCRFS1 EIF3H RSL1D1 RPL14 HUWE1 EIF3K RHEB TCOF1 EIF3I CTDNEP1 PSMB2 MRPS27 PSMB7 ACLY HNRNPA2B1 TIMM17A PARK7 XRCC6 SET UQCRH DGUOK ARIH2 PABPC4 AFG3L2 PTGES3 PRPS2 EIF3D EIF2S2 FAM168B DEXI OXA1L POM121 IDH3B down
## MORF_UBE2I 0.0020161 0.006136 -0.5705273 -2.847191 0 219 EEF1D SNRNP200 DAP3 HDGF CTBP1 CYC1 HGS CHD4 PDAP1 NCL LYPLA2 SART1 EIF6 CCT7 LSM7 JTB CBX3 RALY OTUB1 NUDT1 HSP90AB1 TUFM AATF UBE2I HSPD1 MRPL9 PABPC1 BRD8 CCT2 SNRPE GNAS ILF3 RNPS1 TRIM28 ILF2 BANF1 NONO HNRNPAB HNRNPA1 UBN1 HNRNPUL1 CNPPD1 FBL PTBP1 POLR2A PPIA GANAB PSMB3 SNRNP70 CS TBCB ANP32B SSR2 DHX38 CSK MRPL23 DDX49 KXD1 TOP1 COX6B1 COPS6 PUF60 CFL1 PTMA RPL11 POLR2I HNRNPM RPL27 RPL19 RPL30 RPS24 FUS NAP1L4 PSMD8 RPS6 PPP2R1A USP22 NUP188 RPL31 RPLP2 NDUFS3 NGDN COX4I1 GNB2 UQCRFS1 EIF3H ZNF384 RPL13 CANX ARFGAP2 RPL14 HUWE1 RPL7 EIF3K EIF3I EEF2 CTDNEP1 COX7C PSMB7 RPS7 HNRNPA2B1 PARK7 XRCC6 COX5B SET UQCRH RPL10A SDR39U1 BRD2 NACA SNRPB RPL18 EIF3D FAM168B RPL24 OXA1L RPS5 IDH3B YWHAZ down
## MORF_AP2M1 0.0019724 0.006136 -0.5707562 -2.833811 0 203 EEF1D SLC4A2 P4HB DAP3 HDGF CTBP1 TMED9 AP3D1 CYC1 PDAP1 LYPLA2 TSR3 POLR2H CCT7 GPX4 JTB CBX3 RALY OTUB1 HSP90AB1 UBE2I MAP2K2 ENSA SF3B2 DCTN2 PPP1CA CALR MRPL9 CAPN1 TMEM147 SSNA1 LASP1 SNRPE GNAS EIF3C MRPS12 IMPDH1 COPE BANF1 ARHGDIA HNRNPAB HNRNPUL1 PSMB6 MAP3K11 TCF25 COMMD4 PSMB4 RER1 ATOX1 RPN2 POLR2L PPIA GANAB PLOD3 SDHA TBCB ANP32B SSR2 PRMT1 MRPL23 C9orf16 PKM DDX49 GPI NDUFA1 KXD1 COX6B1 COPS6 STX4 PUF60 CFL1 VCP POLR2I AP1B1 SMARCD2 SOD1 RPL36AL PSMD8 PPP2R1A COG4 DDOST CLTA TRAPPC3 WBP2 HSPA8 KDELR1 ARF5 COX4I1 GNB2 UQCRFS1 DNPEP CANX ARFGAP2 HUWE1 STOML2 RHEB COPS5 URM1 CTDNEP1 PGD COX7C EIF4E2 BUD31 PSMB7 down
## GNF2_MCM4 0.0019455 0.006136 -0.7154031 -2.831529 0 52 UBE2C POLD1 MCM7 ASF1B AURKB MCM2 FEN1 CDCA8 KIF18B PAICS MCM4 FOXM1 CDC20 BUB1 PA2G4 RRM2 ESPL1 AURKA ZWINT LMNB1 TOP2A CENPM SMC4 KIF14 MELK HMMR NDC80 ASPM MCM5 CCNA2 GINS1 RFC4 KIF11 MCM3 MAD2L1 HELLS BUB1B TTK RACGAP1 MCM6 GMNN down
## GNF2_HMMR 0.0019802 0.006136 -0.7259300 -2.786283 0 46 UBE2C AURKB MCM2 FEN1 CDCA8 BIRC5 KIF18B MCM4 FOXM1 CDC20 PLK1 MKI67 BUB1 KIF20A RRM2 ESPL1 AURKA ZWINT TOP2A CENPF SMC4 MELK HMMR NDC80 ASPM CENPE SHCBP1 CCNA2 PRC1 KIF11 DLGAP5 CDK1 BUB1B TTK PLK4 NUSAP1 down
## GNF2_RRM1 0.0019646 0.006136 -0.6358018 -2.764711 0 86 DTYMK UBE2C SSRP1 PCCB MCM7 AURKB MCM2 FEN1 CCT6A CDCA8 BIRC5 KIF18B PAICS MCM4 FOXM1 HNRNPAB CDC20 MKI67 PA2G4 RRM2 AURKA ZWINT TOP2A CENPM CENPF SMC4 KIF14 MELK HMMR SLBP NDC80 ASPM DHFR MCM5 CENPE SHCBP1 HMGB2 CCNA2 PRC1 GINS1 RFC4 KIF11 MCM3 DLGAP5 CDK1 BUB1B TTK PLK4 NUSAP1 RACGAP1 MCM6 SNRPD1 PSMD14 GMNN CHCHD3 down
## GNF2_BUB1B 0.0019646 0.006136 -0.7025268 -2.749165 0 49 UBE2C POLD1 HJURP ASF1B AURKB MCM2 CDCA8 PAICS MCM4 CDC20 PLK1 CEP55 BUB1 PA2G4 KIF20A RRM2 ESPL1 AURKA ZWINT LMNB1 TOP2A CENPM SMC4 KIF14 MELK HMMR NDC80 SPAG5 ASPM NCAPD2 CCNA2 GINS1 KIF11 MCM3 HELLS BUB1B TTK RACGAP1 GMNN NUP205 down
## GNF2_ESPL1 0.0019881 0.006136 -0.7686721 -2.748144 0 35 UBE2C ASF1B AURKB CDCA8 BIRC5 PAICS MCM4 TPX2 FOXM1 CDC20 PLK1 MKI67 KIF2C BUB1 KIF20A RRM2 ESPL1 TOP2A CENPM MELK HMMR SPAG5 ASPM NCAPD2 CENPA CENPE CCNA2 KIF11 MAD2L1 BUB1B down
## MORF_NME2 0.0019763 0.006136 -0.5783043 -2.737828 0 141 EEF1D HDGF CYC1 PDAP1 LYPLA2 TSR3 POLR2H CCT7 JTB RALY OTUB1 RPL38 HSP90AB1 UBE2I HSPD1 CALR PABPC1 ENO1 TMEM147 SSNA1 RPL8 SNRPE ALDOA GNAS NME1 RPS10 BANF1 EEF1A2 PSMB4 PPIA GANAB TBCB RPL12 SSR2 RPS20 MRPL23 C9orf16 RPS16 NDUFA1 COX6B1 COPS6 PUF60 CFL1 RPL11 RPL27 RPL19 RPL30 RPS24 RPL36AL PSMD8 RPS6 RPL31 RPL27A RPLP2 RPS27 RPL35 ARF5 COX4I1 DNPEP RPL13 CANX HUWE1 STOML2 RPL7 URM1 SPAG7 EEF2 COX7C RPS7 XBP1 PFN1 ACTB COX5B RPS3 NACA SNRPB RPS29 RPL18 down
fgsea_plot(fgsea_res$res_c5, pathways_title='C5 GO genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## GO_MITOCHONDRIAL_TRANSLATION 0.0020040 0.0209928 -0.6321793 -2.930251 0 127 MTG2 MRPL4 MRPL24 MRPS34 AARS2 MRPL33 DAP3 MRPL12 TRUB2 UQCC2 TARS2 CDK5RAP1 MRPL28 EARS2 MRPL21 MRPL38 MRPS25 MRPL55 SHMT2 TSFM AURKAIP1 TUFM GADD45GIP1 ERAL1 MRPS7 MRPL20 MRPS23 MRPS2 MRPL9 MTG1 MRPS5 MRPS15 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 MRPL11 MRPL36 MRPS26 RPUSD3 MALSU1 COA3 C1QBP MRPS16 MRPL23 CHCHD1 MRPS33 MRPL15 RPUSD4 MRPS21 MRPL52 MRPS18A IARS2 MRPL17 LARS2 NOA1 MRPS28 MRPL51 MRPS17 MPV17L2 MRPL43 SARS2 MRPL44 UQCC1 NDUFA7 MRPL3 MRPS35 MRPL10 DARS2 MRPL37 down
## GO_IMMUNOGLOBULIN_COMPLEX 0.0020243 0.0209928 -0.6252519 -2.882207 0 124 IGLV3-21 IGHV4-4 LIME1 IGLV5-45 IGKV6D-21 IGHV4-31 IGKV5-2 IGLV5-37 IGLV8-61 IGHV1-45 IGHV4-61 IGLV1-51 IGLV1-36 IGKV4-1 IGLV1-47 IGKV1-5 IGLC7 IGKV1-39 IGLV9-49 IGLV4-69 IGLV3-16 IGLC3 IGHV4-34 IGLV3-22 IGHV4-28 IGHV7-81 IGHV3-30 IGLV7-43 IGHV3-15 IGKV3-20 IGHD IGLV2-14 IGHV2-5 IGLV2-23 IGKV2-28 IGLV2-11 IGLV6-57 IGLV1-44 IGHV3-49 IGKV3D-11 IGLV2-8 IGKV1-17 IGKV1-9 IGHV3-48 IGLC6 IGKV1-6 IGHV3-33 IGKV1-12 IGHV1-24 IGHV4-39 IGKV6-21 IGLJ1 IGLL5 IGHV3-7 IGHV3-74 IGLV5-52 IGKV1-13 IGKV1D-39 IGKV1-16 IGHV3-23 IGLV10-54 IGLV4-60 IGKV2D-29 IGKV2D-26 IGLV3-25 IGHV3-21 IGLV3-12 IGHV3-11 IGKV1D-8 IGLV3-19 IGHV3-13 IGKV2-24 IGLV2-18 TRBC1 IGKV3D-7 IGHV3-64 IGKV3-15 IGLV3-1 CD79B IGHV1-18 IGHV3-73 IGHV2-70 IGKV3D-15 TRBC2 IGHV3-20 IGHV1-3 IGKV1D-13 IGKV1D-33 IGLV7-46 IGLV4-3 down
## GO_PRERIBOSOME 0.0018939 0.0209928 -0.6753925 -2.860590 0 71 NOL6 PDCD11 NOC2L RRP1 FAM207A TBL3 PWP2 UTP14A RRP1B KRI1 FTSJ3 PPAN NOC4L BMS1 IMP4 EIF6 RRS1 NOP14 EBNA1BP2 MPHOSPH10 RRP9 ZNF622 PES1 RRP36 UTP3 NOP56 NOB1 FBXW9 FBL BYSL LAS1L MRTO4 TSR1 DCAF13 WDR74 NOP58 FBLL1 HEATR1 BOP1 RIOK1 NGDN WDR12 RSL1D1 RRP7A UTP6 LTV1 RPS7 UTP18 EMG1 WDR3 down
## GO_MITOCHONDRIAL_PROTEIN_COMPLEX 0.0019920 0.0209928 -0.5678326 -2.856773 0 217 BCS1L MRPL4 NDUFS8 MRPL24 MRPS34 NDUFS6 MRPL33 DAP3 MRPL12 CYC1 MRPL28 PMPCA MTX1 MRPL21 MRPL38 TIMM50 NDUFV1 MRPL55 SPG7 TOMM40L NDUFS2 POLRMT ROMO1 MRPS7 MRPL20 CHCHD10 ANKZF1 NDUFA13 MRPS2 MRPL9 TOMM40 FOXRED1 MRPS5 NDUFA11 MRPS15 MRPL27 MRPL2 MT-ND2 MRPS12 MRPL41 MRPL14 MRPL11 MT-ATP8 MRPL36 MRPS26 MALSU1 BAX COA3 TIMM13 PAM16 NDUFB7 MT-ND1 NDUFS5 SDHA NDUFV3 NDUFB9 CHCHD6 MRPS16 DNAJC11 MRPL23 PPIF AGK NDUFAB1 NDUFB2 MCCC2 NDUFB10 MT-ATP6 NDUFA1 MRPS33 MRPL15 MRPS21 MT-ND4L BCKDHA MRPL52 MRPS18A MT-CYB MT-ND3 MT-ND4 MRPL17 MT-ND5 C12orf65 MRPS28 MRPL51 MRPS17 MPV17L2 POLG MRPL43 MRPL44 BCKDK NDUFS3 DNA2 NDUFA7 MRPL3 COX4I1 UQCRFS1 MRPS35 MRPL10 MRPL37 NDUFS7 UQCRC1 TIMM8B MRPS27 C15orf48 UQCRQ SDHC TIMM10 down
## GO_NCRNA_PROCESSING 0.0020576 0.0209928 -0.5386997 -2.838195 0 325 DUS1L USB1 WDR4 NOL6 RPUSD1 NPM3 ISG20L2 GTPBP3 PDCD11 INTS1 AARS2 PUSL1 RRP1 FAM207A TRMT1 DDX27 TBL3 ADAR PWP2 QTRT1 UTP14A METTL1 WDR55 CDK5RAP1 EXOSC5 RRP1B KRI1 CSTF2 FTSJ3 DGCR8 ERCC2 TSEN54 SRRT PIH1D1 URB1 NSUN2 NVL WDR18 TSR3 DDX51 NOC4L SART1 RRNAD1 BMS1 IMP4 PELP1 RRS1 DDX56 NOP14 NHP2 DHX37 CPSF4 PUS1 EBNA1BP2 TARBP2 CTU2 TRPT1 MPHOSPH10 TRMT12 NAT10 NOP2 RRP9 POLR3K TRMT2B DDX54 EXOSC2 DROSHA METTL2B PES1 RRP36 TUT1 UTP3 NOP56 METTL2A PTCD1 ADAT3 NOB1 TRMT61A INTS5 GAR1 FBL BYSL CHD7 TYW1 DUS3L POP7 LAS1L PA2G4 ANKRD16 MRTO4 RPUSD2 ELAC2 POP1 EIF4A3 NOLC1 YBEY TRMT112 RPS2 RPL7L1 CTU1 EXOSC6 TRMT44 DDX49 TSR1 RPS16 RPUSD4 RPL11 TSR2 PUS7 RBFA TRMU AGO2 RPL27 ELP6 RPS24 TARBP1 DCAF13 WDR74 NOP58 C9orf64 FBLL1 RPS21 GTPBP4 RPS6 PARN MRPL44 GRSF1 HEATR1 RPP40 BOP1 RPS27 ISG20 RIOK1 RPL35 INTS8 NGDN WDR12 CPSF1 ELP5 RSL1D1 EXOSC1 GEMIN4 RPS15 NOL8 RPL14 FARS2 RPL7 TRUB1 URM1 DUS2 RRP7A NUDT16 RNF113A INTS7 RPP38 UTP6 TYW5 MOCS3 TRMT10A RPL26 RPS7 ADAT1 HNRNPA2B1 down
## GO_MITOCHONDRIAL_GENE_EXPRESSION 0.0019569 0.0209928 -0.5934634 -2.822191 0 149 MTG2 MRPL4 MRPL24 MRPS34 AARS2 TBRG4 MRPL33 DAP3 MRPL12 TRUB2 UQCC2 TARS2 CDK5RAP1 MRPL28 EARS2 MRPL21 MRPL38 MRPS25 MRPL55 SHMT2 PUS1 TSFM POLRMT AURKAIP1 TUFM GADD45GIP1 ERAL1 MRPS7 MRPL20 CHCHD10 MRPS23 MRPS2 MRPL9 MTG1 MRPS5 MRPS15 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 MRPL11 MRPL36 MRPS26 RPUSD3 MALSU1 COA3 ELAC2 C1QBP MRPS16 MRPL23 CHCHD1 MRPS33 MRPL15 RPUSD4 MRPS21 MRPL52 MRPS18A IARS2 MRPL17 LARS2 NOA1 MRPS28 MRPL51 MRPS17 MPV17L2 MRPL43 SARS2 MRPL44 UQCC1 NDUFA7 MRPL3 MRPS35 MRPL10 DARS2 MRPL37 down
## GO_RIBOSOME_BIOGENESIS 0.0021097 0.0209928 -0.5434954 -2.785750 0 259 NOL6 RPUSD1 NPM3 MTG2 ISG20L2 PDCD11 NOC2L RRP1 FAM207A DDX27 TBL3 PWP2 UTP14A WDR55 EXOSC5 RRP1B KRI1 FTSJ3 ERCC2 PIH1D1 MYBBP1A URB1 PPAN NVL WDR18 TSR3 DDX51 NOC4L SART1 RRNAD1 BMS1 IMP4 PELP1 EIF6 RRS1 DDX56 NOP14 NHP2 DHX37 EBNA1BP2 RPL38 MPHOSPH10 NAT10 NOP2 RRP9 AATF GNL3L ERAL1 NOM1 ZNF622 MRPS7 MRPL20 MRPS2 DDX54 EXOSC2 DROSHA DHX30 PES1 RRP36 NLE1 UTP3 NOP56 RPS10 NOB1 MRPL11 MRPL36 GAR1 MALSU1 FBL BYSL CHD7 POP7 LAS1L PA2G4 MRTO4 RPUSD2 EIF4A3 NOLC1 DDX31 YBEY RPL12 TRMT112 RPS2 RPL7L1 C1QBP EXOSC6 URB2 PAK1IP1 DDX49 TSR1 RPS16 GTF3A RPL11 TSR2 RBFA RPL27 RPS24 DCAF13 WDR74 NOP58 MPV17L2 VCX FBLL1 RPS21 GTPBP4 RPS6 HEATR1 RPP40 BOP1 RPS27 ISG20 RIOK1 RPL35 NGDN WDR12 RSL1D1 EXOSC1 GEMIN4 MRPL10 RPS15 NOL8 RPL14 RPL26L1 RPL7 GNL2 RRP7A NUDT16 BRIX1 RPP38 UTP6 LTV1 RPLP0P6 RPL26 RPS7 DDX28 RPL10A RPL3 TRMT61B METTL16 POP5 UTP18 EMG1 RPP25 WDR3 RPSA down
## GO_TRANSLATIONAL_TERMINATION 0.0019531 0.0209928 -0.6193628 -2.781257 0 100 JMJD4 MRPL4 MRPL24 MRPS34 APEH MRPL33 DAP3 MRPL12 MRPL28 MRPL21 MRPL38 MRPS25 MRPL55 AURKAIP1 GADD45GIP1 ERAL1 MRPS7 UPF1 MRPL20 MRPS23 MRPS2 MRPL9 MRPS5 MRPS15 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 MRPL11 MRPL36 MRPS26 TRMT112 MRPS16 MRPL23 EIF5A CHCHD1 GLE1 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A MRPL17 C12orf65 MRPS28 MRPL51 MRPS17 MRPL43 MRPL44 MRPL3 MRPS35 MRPL10 MRPL37 down
## GO_ORGANELLAR_RIBOSOME 0.0019455 0.0209928 -0.6414416 -2.774872 0 83 MTG2 MRPL4 MRPL24 MRPS34 MRPL33 DAP3 MRPL12 MRPL28 MRPL21 MRPL38 MRPL55 MRPS7 MRPL20 MRPS2 MRPL9 MTG1 MRPS5 MRPS15 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 MRPL11 MRPL36 MRPS26 MALSU1 MRPS16 MRPL23 CHCHD1 NDUFAB1 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A MRPL17 C12orf65 MRPS28 MRPL51 MRPS17 MPV17L2 MRPL43 MRPL44 NDUFA7 MRPL3 MRPS35 MRPL10 MRPL37 down
## GO_NCRNA_METABOLIC_PROCESS 0.0020492 0.0209928 -0.5128139 -2.753741 0 396 DUS1L USB1 WDR4 NOL6 RPUSD1 NPM3 TDRKH ISG20L2 GTPBP3 PDCD11 INTS1 AARS2 PUSL1 RRP1 FAM207A TRMT1 DDX27 TBL3 ADAR PWP2 QTRT1 UTP14A TARS2 METTL1 WDR55 CDK5RAP1 EXOSC5 RRP1B KRI1 CSTF2 FTSJ3 DGCR8 ERCC2 EARS2 TSEN54 SRRT FARSA PIH1D1 URB1 NSUN2 NVL WDR18 TSR3 DDX51 NOC4L SART1 RRNAD1 BMS1 IMP4 PELP1 RRS1 DDX56 NOP14 NHP2 DHX37 CPSF4 PUS1 AARSD1 EBNA1BP2 TARBP2 CTU2 TRPT1 MPHOSPH10 TRMT12 NAT10 NOP2 XPO5 HARS2 RRP9 POLR3K AIMP2 TRMT2B HRAS DDX54 EXOSC2 DROSHA METTL2B PES1 RRP36 MARS2 TUT1 SND1 DIS3L2 UTP3 NOP56 METTL2A PTCD1 ADAT3 NOB1 TRMT61A INTS5 GAR1 KHSRP FBL BYSL CHD7 TYW1 DUS3L POP7 LAS1L PA2G4 ANKRD16 MRTO4 RPUSD2 ELAC2 POP1 EIF4A3 NOLC1 YBEY TRMT112 RPS2 RPL7L1 CTU1 EXOSC6 TRMT44 DDX49 TSR1 RPS16 RPUSD4 RPL11 TSR2 PUS7 RBFA IARS2 TRMU AGO2 LARS2 RPL27 PARS2 ELP6 RELA RPS24 TARBP1 DEDD2 DCAF13 WDR74 NOP58 C9orf64 FBLL1 RPS21 GTPBP4 RPS6 DALRD3 PARN SARS2 MRPL44 DTD1 GRSF1 HEATR1 RPP40 BOP1 RPS27 ISG20 RIOK1 RPL35 INTS8 NGDN WDR12 CPSF1 ELP5 RSL1D1 EXOSC1 PLD6 GEMIN4 DARS2 RPS15 NOL8 RPL14 FARS2 RPL7 TRUB1 URM1 DUS2 RRP7A NUDT16 RNF113A INTS7 RPP38 UTP6 TYW5 MOCS3 TRMT10A RPL26 RPS7 ADAT1 HNRNPA2B1 down
## GO_MITOCHONDRIAL_TRANSLATIONAL_TERMINATION 0.0019011 0.0209928 -0.6250044 -2.732186 0 86 MRPL4 MRPL24 MRPS34 MRPL33 DAP3 MRPL12 MRPL28 MRPL21 MRPL38 MRPS25 MRPL55 AURKAIP1 GADD45GIP1 ERAL1 MRPS7 MRPL20 MRPS23 MRPS2 MRPL9 MRPS5 MRPS15 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 MRPL11 MRPL36 MRPS26 MRPS16 MRPL23 CHCHD1 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A MRPL17 MRPS28 MRPL51 MRPS17 MRPL43 MRPL44 MRPL3 MRPS35 MRPL10 MRPL37 down
## GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 0.0020202 0.0209928 -0.5076003 -2.722027 0 382 NOL6 RPUSD1 NPM3 MTG2 SNRNP200 ISG20L2 EIF3B PDCD11 NOC2L RRP1 FAM207A DDX27 TBL3 ADAR PWP2 UTP14A PRPF6 WDR55 EXOSC5 RRP1B KRI1 FTSJ3 ERCC2 POLR2D PIH1D1 MYBBP1A URB1 PPAN NVL WDR18 TSR3 DDX51 NOC4L SART1 RRNAD1 BMS1 IMP4 PELP1 EIF6 PRPF19 RRS1 DDX56 NOP14 NHP2 DHX37 LSM4 EBNA1BP2 NOL3 CD2BP2 TARBP2 RPL38 MPHOSPH10 NAT10 NOP2 HSP90AB1 USP39 RRP9 RUVBL1 AATF GNL3L ERAL1 NOM1 ZNF622 MRPS7 MRPL20 DDX23 MRPS2 DDX54 EXOSC2 DROSHA DHX30 PES1 CPSF6 SNRPE RRP36 EIF3C NLE1 SRPK1 UTP3 NOP56 RPS10 NOB1 EIF3A MRPL11 MRPL36 GAR1 MALSU1 FBL BYSL PRMT5 CHD7 SF3A2 XAB2 POP7 TXNL4A LAS1L PA2G4 EIF3G MRTO4 RPUSD2 EIF4A3 NOLC1 DDX31 YBEY RPL12 TRMT112 RPS2 RPL7L1 C1QBP EXOSC6 SNRPC EIF3CL URB2 RUVBL2 CELF5 PAK1IP1 DDX49 TSR1 AAR2 RPS16 GEMIN7 PRMT7 GTF3A RPL11 TSR2 GEMIN2 TGS1 RBFA AGO2 RPL27 RPS24 GEMIN5 DCAF13 CELF4 WDR74 NOP58 MPV17L2 VCX FBLL1 RPS21 GTPBP4 RPS6 HEATR1 RPP40 SF3A1 BOP1 RPS27 ISG20 SNRPF RIOK1 RPL35 PRPF31 NGDN WDR12 EIF3H RSL1D1 EXOSC1 GEMIN4 MRPL10 RPS15 NOL8 RPL14 RPL26L1 RPL7 EIF3K GNL2 EIF3I SFSWAP RRP7A NUDT16 BRIX1 RPP38 UTP6 SRSF6 LTV1 RPLP0P6 RPL26 RPS7 USP4 SNRPD2 SF1 DDX28 SF3A3 SNRPD1 RPL10A RPL3 TRMT61B METTL16 POP5 UTP18 EMG1 RPP25 WDR3 SNRPB CPSF7 RPSA NSUN5 PTGES3 CELF3 DHX9 NOL9 SDAD1 COIL TFB2M EIF3D EIF2S2 RPL24 SRPK2 NUFIP1 down
## GO_RRNA_METABOLIC_PROCESS 0.0020450 0.0209928 -0.5487465 -2.714743 0 195 NOL6 RPUSD1 NPM3 ISG20L2 PDCD11 RRP1 FAM207A DDX27 TBL3 PWP2 UTP14A WDR55 EXOSC5 RRP1B KRI1 FTSJ3 ERCC2 PIH1D1 URB1 NVL WDR18 TSR3 DDX51 NOC4L SART1 RRNAD1 BMS1 IMP4 PELP1 RRS1 DDX56 NOP14 NHP2 DHX37 EBNA1BP2 MPHOSPH10 NAT10 NOP2 RRP9 DDX54 EXOSC2 DROSHA PES1 RRP36 UTP3 NOP56 NOB1 GAR1 FBL BYSL CHD7 POP7 LAS1L PA2G4 MRTO4 RPUSD2 EIF4A3 NOLC1 YBEY TRMT112 RPS2 RPL7L1 EXOSC6 DDX49 TSR1 RPS16 RPL11 TSR2 RBFA RPL27 RPS24 DEDD2 DCAF13 WDR74 NOP58 FBLL1 RPS21 GTPBP4 RPS6 HEATR1 RPP40 BOP1 RPS27 ISG20 RIOK1 RPL35 NGDN WDR12 RSL1D1 EXOSC1 GEMIN4 RPS15 NOL8 RPL14 RPL7 RRP7A NUDT16 RPP38 UTP6 RPL26 RPS7 RPL10A SLFN13 TRMT61B METTL16 POP5 UTP18 EMG1 RPP25 WDR3 down
## GO_RIBONUCLEOPROTEIN_COMPLEX 0.0019157 0.0209928 -0.4833638 -2.705294 0 630 PABPC1L NOL6 MRPL4 SNRNP200 EIF3B MRPL24 MRPS34 PDCD11 SMG5 NOC2L RRP1 FAM207A MRPL33 DAP3 MRPL12 TBL3 ADAR PWP2 SNRNP25 PKP1 TERC UTP14A PRPF6 ALYREF EIF4G1 MRPL28 RRP1B KRI1 RPL39L FTSJ3 NCL PIH1D1 LARP1 PKP3 PPAN MRPL21 NVL MRPL38 NOC4L SART1 BMS1 IMP4 EIF6 PRPF19 RRS1 NOP14 NHP2 MRPL55 LSM7 PNN LSM4 EBNA1BP2 CD2BP2 TARBP2 JAKMIP1 DDX41 RALY SNORA74A RPL38 MPHOSPH10 NAT10 USP39 XPO5 RRP9 RUVBL1 EFTUD2 SRP68 GNL3L ZNF622 MRPS7 UPF1 U2AF2 RPL37 MRPL20 DDX23 SF3B2 EEFSEC HTATSF1 PABPC3 MRPS2 CALR MRPL9 SUGP1 CACTIN PABPC1 MRPS5 IGHMBP2 DAZAP1 NUP62 MRPS15 PES1 RPL8 CPSF6 MRPL27 MRPL2 SNRPE SNRPA RRP36 ILF3 PABPN1 EIF3C MRPS12 SND1 MRPL41 MRPL14 DIS3L2 UTP3 CCDC12 NOP56 RPS10 ILF2 NOB1 ZMAT2 RBM28 FBXW9 EIF3A RBM42 MRPL11 HNRNPAB MRPL36 HNRNPA1 SRA1 MRPS26 UNK GAR1 DHX8 MALSU1 AKAP8L FBL BYSL WDR83 SF3A2 XAB2 POP7 TXNL4A GTF3C1 LAS1L EIF3G SNRNP70 MRTO4 POP1 TERT EIF4A3 NOLC1 RPL12 RPS2 DHX38 RPL7L1 RPL37A ZMAT5 HNRNPU RPS20 SNRPC EIF3CL PSMA6 MRPS16 RUVBL2 TRA2A TOP2A CELF5 MRPL23 SRRM2 NDUFAB1 FXR2 RPL36 TSR1 AAR2 RPS16 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A MCRS1 RPL11 GEMIN2 TGS1 SLBP MRPL17 AGO2 HNRNPM RPL27 RPL19 GAPDH C12orf65 RPL30 SNRNP35 RPS24 PPIL1 FUS SF3B3 DCAF13 CELF4 MRPS28 WDR74 MRPL51 CWC25 NOP58 MRPS17 MPV17L2 TTF2 FBLL1 RPS21 RPL36AL RPS6 MRPL43 MRPL44 RBM14 HEATR1 RPL31 RPP40 LSM10 RPL27A RPLP2 SF3A1 HNRNPL PPIH RBM38 MRPL3 HSPA8 BOP1 RPS27 SNRPF RIOK1 RPL35 RPL41 PRPF31 NGDN WDR12 DERL3 RPL28 EIF3H RSL1D1 MRPS35 NR0B1 SLIRP GEMIN4 MRPL10 HNRNPA0 RPL13 RPS15 NOL8 MRPL37 RPL14 RPL26L1 SMG7 TEP1 RPL7 RPLP1 APOBEC3F EIF3K RHEB PRPF4 EIF3I CWF19L1 EEF2 GPATCH1 RRP7A RMRP U2AF1L4 WRAP53 MRPS27 BUD31 RNF113A RPP38 HNRNPF UTP6 MSI2 CIRBP LTV1 RPLP0P6 RPL26 HNRNPA1L2 BRCA1 PPP1R8 RPS7 HNRNPA2B1 HSF1 ACTB SNRPD2 SF1 CWC15 SRP54 SF3A3 SNRPD1 RPS3 RPL10A RPL3 TFIP11 PRPF40B MRPL40 POP5 UTP18 EMG1 RPP25 WDR3 SNRPB RPSA PABPC4 RPS29 RPL18 MRPL49 MRPL53 down
## GO_TRANSLATIONAL_ELONGATION 0.0020000 0.0209928 -0.5737694 -2.652808 0 125 EEF1D MRPL4 MRPL24 MRPS34 MRPL33 DAP3 MRPL12 DPH7 MRPL28 GTPBP2 ZNF598 MRPL21 MRPL38 MRPS25 MRPL55 TSFM DPH2 AURKAIP1 TUFM GADD45GIP1 ERAL1 MRPS7 MRPL20 EEFSEC MRPS23 MRPS2 MRPL9 MRPS5 MRPS15 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 MRPL11 MRPL36 EEF1A2 MRPS26 EIF4A3 MRPS16 MRPL23 EIF5A CHCHD1 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A MRPL17 RPL30 DPH1 MRPS28 MRPL51 MRPS17 MRPL43 MRPL44 RPLP2 MRPL3 MRPS35 MRPL10 MRPL37 RPLP1 EEF2 MRPS27 down
## GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 0.0019920 0.0209928 -0.5550241 -2.644667 0 152 MRPL4 MRPL24 MRPS34 MRPL33 DAP3 MRPL12 MRPL28 RPL39L MRPL21 MRPS25 MRPL55 RPL38 MRPS7 RPL37 MRPL20 MRPS23 MRPS2 MRPL9 MRPS5 MRPS15 RPL8 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 RPS10 MRPL11 MRPL36 RPL12 RPS2 RPL7L1 RPL37A RPS20 MRPS16 MRPL23 RPL36 RPS16 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A RPL11 MRPL17 RPL27 RPL19 RPL30 RPS24 MRPL51 MRPS17 RPS21 RPL36AL RPS6 RPL22L1 MRPL43 RPL31 RPL27A RPLP2 NDUFA7 MRPL3 RPS27 RPL35 RPL41 RPL28 MRPS35 MRPL10 RPL13 RPS15 MRPL37 RPL14 RPL26L1 RPL7 RPLP1 RPLP0P6 RPL26 RPS7 RPS3 RPL10A RPL3 RPSA RPS29 RPL18 MRPL49 down
## GO_RIBOSOME 0.0020243 0.0209928 -0.5260890 -2.628707 0 211 MTG2 MRPL4 MRPL24 MRPS34 MRPL33 DAP3 MRPL12 MRPL28 RPL39L LARP1 MRPL21 MRPL38 MRPS25 MRPL55 RPL38 AURKAIP1 GADD45GIP1 SRP68 MRPS7 RPL37 MRPL20 MRPS23 MRPS2 MRPL9 MTG1 MRPS5 MRPS15 RPL8 MRPL27 MRPL2 RRBP1 APEX1 MRPS12 MRPL41 MRPL14 RPS10 MRPL11 MRPL36 MRPS26 MALSU1 RPL12 RPS2 RPL7L1 RPL37A RPS20 MRPS16 MRPL23 CHCHD1 NDUFAB1 FXR2 RPL36 RPS16 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A RPL11 MRPL17 DNAJC21 RPL27 RPL19 C12orf65 RPL30 RPS24 MRPS28 MRPL51 MRPS17 MPV17L2 RPS21 RPL36AL RPS6 RPL22L1 MRPL43 MRPL44 RPL31 RPL27A RPLP2 NDUFA7 MRPL3 RPS27 RPL35 RPL41 RPL28 EIF3H MRPS35 NR0B1 MRPL10 RPL13 RPS15 MRPL37 CANX RPL14 RPL26L1 RPL7 RPLP1 EEF2 MRPS27 METTL17 RPLP0P6 RPL26 RPS7 RPS6KL1 SF1 RPS3 RPL10A RPL3 MRPL40 RPSA RPS29 RPL18 MRPL49 MRPL53 DHX9 APOD MRPL34 RPL24 NUFIP1 MRPL13 RPS5 down
## GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 0.0019048 0.0209928 -0.6328447 -2.596535 0 62 NOC2L FTSJ3 URB1 PPAN NVL EIF6 RRS1 NHP2 EBNA1BP2 RPL38 NOP2 ZNF622 MRPL20 DHX30 PES1 NLE1 MRPL11 MALSU1 LAS1L MRTO4 RPL12 RPL7L1 PAK1IP1 GTF3A RPL11 WDR74 GTPBP4 BOP1 RPL35 WDR12 RSL1D1 RPL14 RPL26L1 RPL7 BRIX1 RPLP0P6 RPL26 DDX28 RPL10A RPL3 NOL9 SDAD1 RPL24 down
## GO_LARGE_RIBOSOMAL_SUBUNIT 0.0019763 0.0209928 -0.5667432 -2.575580 0 108 MRPL4 MRPL24 MRPL33 MRPL12 MRPL28 RPL39L MRPL21 MRPL38 MRPL55 RPL38 RPL37 MRPL20 MRPL9 RPL8 MRPL27 MRPL2 MRPL41 MRPL14 MRPL11 MRPL36 MALSU1 RPL12 RPL7L1 RPL37A MRPL23 NDUFAB1 FXR2 RPL36 MRPL15 MRPL52 MRPS18A RPL11 MRPL17 RPL27 RPL19 C12orf65 RPL30 MRPL51 MPV17L2 RPL36AL MRPL43 MRPL44 RPL31 RPL27A RPLP2 MRPL3 RPL35 RPL41 RPL28 MRPL10 RPL13 MRPL37 RPL14 RPL26L1 RPL7 RPLP1 RPLP0P6 RPL26 RPL10A RPL3 MRPL40 RPL18 MRPL49 MRPL53 MRPL34 RPL24 MRPL13 down
## GO_RIBOSOMAL_SUBUNIT 0.0020619 0.0209928 -0.5321764 -2.573207 0 172 MRPL4 MRPL24 MRPS34 MRPL33 DAP3 MRPL12 MRPL28 RPL39L MRPL21 MRPL38 MRPL55 RPL38 MRPS7 RPL37 MRPL20 MRPS2 MRPL9 MRPS5 MRPS15 RPL8 MRPL27 MRPL2 MRPS12 MRPL41 MRPL14 RPS10 MRPL11 MRPL36 MRPS26 MALSU1 RPL12 RPS2 RPL7L1 RPL37A RPS20 MRPS16 MRPL23 NDUFAB1 FXR2 RPL36 RPS16 MRPS33 MRPL15 MRPS21 MRPL52 MRPS18A RPL11 MRPL17 RPL27 RPL19 C12orf65 RPL30 RPS24 MRPS28 MRPL51 MRPS17 MPV17L2 RPS21 RPL36AL RPS6 MRPL43 MRPL44 RPL31 RPL27A RPLP2 MRPL3 RPS27 RPL35 RPL41 RPL28 MRPS35 MRPL10 RPL13 RPS15 MRPL37 RPL14 RPL26L1 RPL7 RPLP1 MRPS27 RPLP0P6 RPL26 RPS7 RPS3 RPL10A RPL3 MRPL40 RPSA RPS29 RPL18 MRPL49 MRPL53 down
## GO_OXIDATIVE_PHOSPHORYLATION 0.0020080 0.0209928 -0.5538951 -2.524600 0 111 NDUFS8 NDUFS6 UQCC2 CYC1 NDUFV1 SHMT2 NDUFS2 CHCHD10 NDUFA13 NDUFA11 MT-CO2 MT-ND2 SLC25A23 COX6C MT-ATP8 CCNB1 NDUFB7 MT-ND1 NDUFS5 SDHA MT-ND6 NDUFV3 NDUFB9 PPIF NDUFAB1 NDUFB2 NDUFB10 MT-ATP6 NDUFA1 COX6B1 MT-ND4L MT-CYB VCP MT-ND3 MT-ND4 MT-ND5 NDUFS3 NDUFA7 COA6 COQ9 COX4I1 UQCRFS1 NDUFS7 STOML2 UQCRC1 CDK1 COX7C UQCRQ SDHC MIR210 PARK7 UQCR11 COX5B UQCRH MT-CO3 SDHAF2 down
## GO_RESPIRATORY_CHAIN_COMPLEX 0.0019011 0.0209928 -0.5885888 -2.510433 0 75 BCS1L NDUFS8 NDUFS6 CYC1 NDUFV1 NDUFS2 NDUFA13 FOXRED1 NDUFA11 MT-CO2 MT-ND2 COA3 NDUFB7 MT-ND1 NDUFS5 SDHA NDUFV3 NDUFB9 NDUFAB1 NDUFB2 NDUFB10 NDUFA1 COX6B1 MT-ND4L MT-CYB MT-ND3 MT-ND4 MT-ND5 NDUFS3 NDUFA7 COX4I1 UQCRFS1 NDUFS7 UQCRC1 C15orf48 UQCRQ SDHC down
## GO_RNA_PROCESSING 0.0018939 0.0209928 -0.4391867 -2.509839 0 817 DUS1L PABPC1L USB1 WDR4 NOL6 TRMT2A RPUSD1 NPM3 SNRNP200 ISG20L2 IWS1 GTPBP3 ZC3H3 PDCD11 FASTK INTS1 AARS2 SUPT5H PUSL1 RRP1 TBRG4 FAM207A TRMT1 DDX27 TBL3 ADAR PWP2 PRCC SNRNP25 QTRT1 TRUB2 UTP14A PRPF6 METTL1 ALYREF WDR55 CDK5RAP1 EXOSC5 RRP1B KRI1 CSTF2 FTSJ3 DGCR8 ERCC2 POLR2D TSEN54 SRRT NCL PIH1D1 URB1 RNF40 SCAF1 NSUN2 NVL WDR18 TSR3 DDX51 NOC4L SART1 POLR2H RRNAD1 BMS1 IMP4 PELP1 PRPF19 ERCC3 RRS1 DDX56 NOP14 NHP2 LSM7 PNN DHX37 LSM4 CPSF4 PUS1 POLR2J CDK12 EBNA1BP2 SCNM1 SYMPK NOL3 CD2BP2 CLASRP TARBP2 DDX41 CTU2 RALY TRPT1 THOC6 MPHOSPH10 TRMT12 NAT10 NOP2 AURKAIP1 USP39 RRP9 POLR3K EFTUD2 TP53 U2AF2 PHRF1 DDX23 MAP2K2 SF3B2 HTATSF1 TRMT2B DDX54 EXOSC2 SUGP1 CACTIN CMTR1 CHERP SSU72 DROSHA PABPC1 DAZAP1 METTL2B PES1 CPSF6 SNRPE SNRPA RRP36 PABPN1 DCPS TUT1 RNPS1 SRPK1 UTP3 BRDT NOP56 METTL2A PTCD1 ADAT3 NOB1 ZMAT2 RBM28 RBM42 TRMT61A NONO RBM19 HNRNPA1 ACIN1 PQBP1 HNRNPUL1 RPUSD3 THOC5 INTS5 GAR1 CCNB1 DHX8 AKAP8L KHSRP FBL DDX42 BYSL PRMT5 CHD7 TYW1 POLR2E WDR83 DUS3L PAF1 SF3A2 PTBP1 THOC3 POLR2A NCOR2 XAB2 SUPT6H POP7 TXNL4A LAS1L PA2G4 RBFOX3 POLR2L SNRNP70 ESRP2 ANKRD16 MRTO4 RPUSD2 ELAC2 POP1 TERT EIF4A3 NOLC1 PPP1R9B YBEY TRMT112 RPS2 DHX38 RPL7L1 C1QBP DDX39A CTU1 EXOSC6 ZMAT5 HNRNPU SNRPC TRA2A TRMT44 EGFR CELF5 ESRP1 SRRM2 FXR2 GTF2F1 DDX49 TSR1 AAR2 RPS16 CDK11B GEMIN7 PRMT7 RPUSD4 PUF60 RPL11 TSR2 POLR2I GEMIN2 ZC3H7B UPF3B PUS7 TGS1 SLBP RBFA TRMU AGO2 RP9 HNRNPM RPL27 WDR33 ELP6 PRDX6 DDX46 POLR2F RPRD1B SNRNP35 RPS24 PPIL1 FUS TARBP1 GEMIN5 SF3B3 DEDD2 DCAF13 CELF4 WDR74 CWC25 NOP58 TTF2 NCBP2 C9orf64 FBLL1 CHTOP RPS21 GTPBP4 RPS6 PPP2R1A PARN USP49 MRPL44 GRSF1 HEATR1 RPP40 LSM10 SF3A1 CDK9 HNRNPL PPIH RBM38 RPRD2 SAFB HSPA8 CLK3 BOP1 RPS27 ERN1 ISG20 SNRPF SUGP2 RIOK1 RPL35 PRPF31 INTS8 NGDN RIPK1 WDR12 CPSF1 ELP5 RSL1D1 EXOSC1 GEMIN4 HNRNPA0 RPS15 NOL8 RPL14 FARS2 RPL7 TRUB1 PRPF4 URM1 ARL6IP4 DUS2 CWF19L1 SFSWAP GPATCH1 RRP7A RMRP RBM6 U2AF1L4 NUDT16 BUD31 RNF113A INTS7 RPP38 HNRNPF UTP6 TYW5 MOCS3 SRSF6 CIRBP TRMT10A CSTF1 RPL26 HNRNPA1L2 PPP1R8 RPS7 ADAT1 HNRNPA2B1 USP4 ZC3H11A down
## GO_MITOCHONDRIAL_LARGE_RIBOSOMAL_SUBUNIT 0.0018519 0.0209928 -0.6286421 -2.506342 0 53 MRPL4 MRPL24 MRPL33 MRPL12 MRPL28 MRPL21 MRPL38 MRPL55 MRPL20 MRPL9 MRPL27 MRPL2 MRPL41 MRPL14 MRPL11 MRPL36 MALSU1 MRPL23 NDUFAB1 MRPL15 MRPL52 MRPS18A MRPL17 C12orf65 MRPL51 MPV17L2 MRPL43 MRPL44 MRPL3 MRPL10 MRPL37 down
## GO_90S_PRERIBOSOME 0.0018622 0.0209928 -0.7298131 -2.498775 0 29 NOL6 NOC2L FAM207A TBL3 PWP2 KRI1 NOC4L BMS1 IMP4 NOP14 MPHOSPH10 PES1 RRP36 FBXW9 HEATR1 BOP1 WDR12 RSL1D1 RRP7A UTP6 UTP18 WDR3 down
## GO_ORGANELLE_INNER_MEMBRANE 0.0019455 0.0209928 -0.4555908 -2.483289 0 461 SLC25A39 BCS1L ABCB8 MTG2 MRPL4 NDUFS8 MRPL24 SLC25A22 MRPS34 NDUFS6 LETM1 MRPL33 DAP3 MRPL12 SLC25A10 PSEN2 UQCC2 CYC1 MRPL28 CPS1 PMPCA NME4 MRPL21 MRPL38 TIMM50 TRAP1 NDUFV1 ATAD3A MRPS25 MRPL55 ACAD9 SHMT2 LMNB2 FPGS SPG7 CBX3 TMEM177 NDUFS2 SCO2 TM7SF2 ROMO1 AURKAIP1 TMEM120B ATAD3B ERAL1 MRPS7 MRPL20 CHCHD10 HSPD1 MRPS23 TIMM44 NDUFA13 MRPS2 MRPL9 TOMM40 SLC25A15 MTG1 MFSD10 ACADVL FOXRED1 BDH1 MRPS5 NDUFA11 MT-CO2 MRPS15 SIGMAR1 MRPL27 ALDH18A1 MRPL2 SPAG4 MT-ND2 SLC25A23 MRPS12 MRPL41 SLC25A45 MRPL14 THEM4 COX6C SPHK2 FDXR MRPL11 BOK MT-ATP8 MRPL36 MRPS26 SFXN4 COA3 AIFM1 TIMM13 PET100 PAM16 NDUFB7 MT-ND1 NDUFS5 SDHA SLC25A18 TMEM201 UCP2 MT-ND6 NDUFV3 NDUFB9 CPOX CHCHD6 MRPS16 PHB DNAJC11 LMNB1 MRPL23 PPIF AGK CHCHD1 PLA2G4A PGS1 NDUFAB1 MPV17 NDUFB2 NDUFB10 MT-ATP6 CRAT SLC25A16 NDUFA1 ENDOG MRPS33 MRPL15 COX6B1 MRPS21 MT-ND4L MRPL52 MRPS18A MT-CYB MT-ND3 MT-ND4 MRPL17 MT-ND5 GCAT MRS2 NOA1 MRPS28 MRPL51 MRPS17 MPV17L2 L2HGDH PISD MRPL43 MRPL44 UCP3 COQ4 SLC25A42 UCP1 NDUFS3 UQCC1 NDUFA7 GOT2 MRPL3 P2RX3 LYN ERN1 MCUR1 PPOX SFXN1 COQ9 COX4I1 UQCRFS1 MRPS35 SLC8B1 DHODH MRPL10 MRPL37 NDUFS7 COQ3 STOML2 NDUFAF6 UQCRC1 ECSIT MTCH1 COX7C TIMM8B MRPS27 C15orf48 UQCRQ CYP2E1 SDHC TIMM10 SLC25A35 SIRT4 TIMM17A IFI6 SLC25A11 LDHD UQCR11 COX5B SRC NDUFAF2 UQCRH DPY19L1 LEMD2 RPS3 MT-CO3 AIFM3 BCL2L1 NUTF2 down
## GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX 0.0019493 0.0209928 -0.5508061 -2.474187 0 101 BCS1L NDUFS8 NDUFS6 CYC1 TIMM50 NDUFV1 SPG7 NDUFS2 ROMO1 CHCHD10 NDUFA13 FOXRED1 NDUFA11 MT-ND2 MT-ATP8 COA3 PAM16 NDUFB7 MT-ND1 NDUFS5 SDHA NDUFV3 NDUFB9 CHCHD6 DNAJC11 PPIF AGK NDUFAB1 NDUFB2 NDUFB10 MT-ATP6 NDUFA1 MT-ND4L MT-CYB MT-ND3 MT-ND4 MT-ND5 NDUFS3 NDUFA7 COX4I1 UQCRFS1 NDUFS7 UQCRC1 C15orf48 UQCRQ SDHC TIMM10 down
## GO_CATALYTIC_ACTIVITY_ACTING_ON_RNA 0.0020492 0.0209928 -0.4675687 -2.471279 0 333 DUS1L USB1 WDR4 TRMT2A SNRNP200 ISG20L2 DHX34 AARS2 TRMT1 DDX27 POLR1A QTRT1 TARS2 METTL1 EXOSC5 FTSJ3 HELZ2 DGCR8 ENDOV EARS2 POLR2D TSEN54 FARSA NSUN2 DDX51 POLR2H RRNAD1 DDX56 DHX37 PUS1 AARSD1 POLR2J RPAP1 DDX41 POLR3A RNASEH2A POLRMT TRPT1 TRMT12 NOP2 HARS2 POLR3K UPF1 DDX23 TRMT2B FEN1 LRRC47 DDX54 EXOSC2 CMTR1 POLR1B DROSHA IGHMBP2 METTL2B POLR3H DHX30 MARS2 DDX12P DCPS APEX1 TUT1 DDX55 SND1 DIS3L2 METTL2A POLR3E NOB1 TRMT61A POLR1C DHX8 FBL DDX42 TYW1 POLR2E DUS3L POLR2A POP7 POLR2L ELAC2 POP1 TERT EIF4A3 DDX31 YBEY TRMT112 DHX38 DDX39A MED20 EXO1 TRMT44 RNASEH1 DDX49 MOV10 ENDOG POLR2J3 POLR2I TGS1 IARS2 AGO2 LARS2 PARS2 DHX57 DDX46 POLR2F TARBP1 DDX19A PCIF1 FBLL1 CRCP DALRD3 PARN SARS2 MRPL44 DTD1 down
## GO_VIRAL_GENE_EXPRESSION 0.0020534 0.0209928 -0.5043046 -2.470529 0 185 TRIM11 EIF3B USF1 SUPT5H RRP1B SMARCA4 TFAP4 NUP210 POLR2D NELFA POLR2H NELFCD NELFB POLR2J TARBP2 RPL38 NUP107 RPL37 SMARCB1 NUP62 RPL8 RPS10 EIF3A PSMC3 TRIM8 POLR2E PTBP1 POLR2A SEC13 POLR2L EIF3G TPR RPL12 RPS2 RPL37A RAE1 HPN RPS20 GTF2F1 RPL36 RPS16 NUP85 RPL11 TRIM14 POLR2I AAAS RPL27 RPL19 TRIM62 RPL30 FURIN POLR2F RPS24 NUP93 USF2 RPS21 RPS6 POM121C NUP188 RPL31 RPL27A RPLP2 CDK9 RPS27 RPL35 RPL41 RPL28 RPL13 RPS15 NUP155 RPL14 RPL7 RPLP1 NUP214 RPL26 RPS7 MON1B RPS3 RPL10A RPL3 RPSA NUP205 CTDP1 RPS29 RPL18 DHX9 EIF3D RPL24 POU2F3 RPS5 POM121 down
## GO_SMALL_SUBUNIT_PROCESSOME 0.0019455 0.0209928 -0.7048819 -2.465539 0 33 NOL6 PDCD11 TBL3 PWP2 UTP14A NOC4L IMP4 NOP14 MPHOSPH10 RRP9 UTP3 NOP56 FBL DCAF13 NOP58 FBLL1 HEATR1 NGDN UTP6 RPS7 UTP18 EMG1 WDR3 down
fgsea_plot(fgsea_res$res_c6, pathways_title='C6 oncogenic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------------------- ---------- ---------- ----------- ---------- ------------- ----- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## MYC_UP.V1_UP 0.0019685 0.0092975 -0.5455209 -2.623560 0 157 TOP1MT WDR4 NOL6 SMYD5 ALG3 SLC25A22 RPTOR REPIN1 TRMT1 HS6ST2 FAM86C1 VPS9D1 QTRT1 UTP14A METTL1 ECE2 EXOSC5 NR2C2AP C19orf48 QSOX2 NOC4L NOP14 PUS1 B3GNTL1 RRP12 MNT TSFM MPHOSPH10 RRP9 ISOC2 DGKD CCDC124 CHCHD10 PRR7 SLC25A15 SAC3D1 DLL3 PES1 SCFD2 GLS2 NLE1 C12orf66 DPP7 MON1A LRRC61 PPRC1 WDR83 IPO4 LAS1L MRTO4 TMEM201 KLF16 NEFH CD320 DGAT2 AGPAT3 SPATC1L PMM2 PLA2G4A AHSA1 RPUSD4 DCAF4 PUS7 USE1 GEMIN5 MMP25 SORD KLRG2 RPP40 ABCC6P2 SLC29A4 PLD6 CD3EAP TDRD10 ICAM5 SLC19A1 TSSC4 CDCA7L DCTPP1 TGFBRAP1 TECTB CGREF1 AMPD2 down
## PRC2_EED_UP.V1_DN 0.0020284 0.0092975 -0.5196398 -2.538479 0 179 RECQL4 SLC26A1 LRRC20 PC ABCB8 TRMT2A DNAJB2 TBL3 TMEM59L PWP2 MYBL2 QTRT1 CAD PHKG2 TNK2 SLC35C2 ERCC2 GSDMD POLD1 SYMPK TRIM46 AP1G2 STXBP2 PACSIN3 FASN ASF1B TACC3 RANGAP1 ANKZF1 MCM2 EXOSC2 INCENP CDCA8 WIZ TUT1 MCM10 TOP3B BTBD2 CHAF1B DBF4B USP20 CDK18 ACY1 TSC2 PLK1 CLPB IDH2 DLK2 ABCB9 TCIRG1 GALK1 AMDHD2 DDX31 PACS1 SIPA1 ATP13A2 ORC1 CLSPN VAC14 GLE1 KIF4A MICALL2 PRMT7 RAD54L JUP APLP1 RAD54L2 TUBGCP2 CORO1A ZNF446 FRS2 PLXNB1 TAF1C MCM5 BBC3 BCKDK NUP188 FBXL6 ODF2 PAGR1 RIPK1 C1orf112 LIPE HELLS KCNS1 MICAL1 BUB1B ALG12 INHBB down
## CAMP_UP.V1_UP 0.0020367 0.0092975 -0.4900429 -2.396999 0 181 SMYD5 P4HB PYCR2 DAP3 LONP1 HSPA5 TMED9 GMPPA CEP250 RHOT2 EARS2 RBCK1 TFPI2 NDUFV1 MAEA HAX1 SIL1 GAS5 TOMM40L NDUFS2 RUVBL1 AATF DPM2 CHAF1A RABGGTA DDX23 NUAK2 CCDC124 TMEM9 CMTR1 CLPTM1 POLR3H WDR24 ALDOA NQO2 NME1 SRPK1 ILF2 COPE TYMP TRMT61A WASH3P HSP90B1 SEC13 IPO4 PA2G4 HDLBP CS TRIM38 ARF1 HNRNPU DPAGT1 PRMT1 FAHD2A SLC35A4 CNDP2 BSCL2 TRIM2 MIDN HSPBP1 MRPL15 SEC61A1 MRPS18A NRSN2 AAAS PMAIP1 HSPA9 down
## EIF4E_UP 0.0020080 0.0092975 -0.5105110 -2.225247 0 88 NPM3 SNRNP25 METTL1 PFDN2 UBFD1 CACNB3 FN3KRP TALDO1 TUFM ISOC2 DNPH1 NKX2-8 CAMK2N2 VPS28 C16orf91 VPS72 MON1A SNX8 SRXN1 ANKRD16 RSAD1 EIF4A3 C8orf33 MYH6 PHYKPL PMM2 CHCHD1 FAM117A AHSA1 SNTB1 UROS MRPL17 DEDD down
## STK33_SKM_UP 0.0020576 0.0092975 0.4308794 2.190295 0 246 TCTEX1D1 CYBRD1 APPL2 PID1 EVI5 CD36 RGCC STX12 FABP4 RCBTB2 DNAJB4 DYNC2LI1 LPAR6 TTLL7 NLRC4 OR52K3P OLR1 TMOD2 CREBRF VSIG4 PPP1R17 STAM2 KITLG KLF6 OSBPL11 FGD4 CD58 DAAM1 PALLD SERAC1 ACTA2 SGK1 SLC12A6 KMO FGR SYNJ2BP WDR19 MFAP3L SLC38A6 PTPRM GNG11 NCF2 CFL2 GPR65 P2RY14 HMOX1 C5AR1 MNS1 SNX16 BCL2A1 SAMD8 BBS12 GPR34 CDC37L1 PLK2 NAMPT SETBP1 MFAP3 CD101 ARL5B KCNJ2 TRIM23 KIAA1841 RNF141 SUCNR1 TLR1 RND3 CRK CALHM2 ETV1 BTBD7 SH2B3 FGL2 TYROBP PTPRO TMTC3 CYBB ZBTB6 TMEM107 ZNF763 TGFB1I1 TFEC IL1B TFPI MXD1 GPR137B THBD IL1A CD86 CTSK ANXA1 ADAM28 SULF2 RTN1 SIPA1L2 LPXN ST20 MIR22HG ZCCHC14 MPPED2 ADM GLIPR1 GPR183 FOS TNFRSF11B CDKN1C IL15 ARID5B ARHGAP42 EMP3 DUSP1 HBEGF GK3P CD53 JUNB CPEB2 CEP19 PHLDA1 SKIL TMEM71 LY96 NBEAL1 TWF1 DPY19L4 up
## RPS14_DN.V1_DN 0.0019881 0.0092975 -0.4478327 -2.182602 0 172 GPATCH4 LRRC20 PC TK1 PYCR1 TBRG4 MRPL12 SPTB MYBL2 CAD GCDH ERCC2 ELMO3 RRS1 POLD1 TUBG1 EPCAM SRM SRD5A3 THEM6 CBS ISOC2 ZNF74 PSAT1 MRPS2 INCENP MACROD1 DDN NMU PES1 NLE1 MCM10 DBH CDC20 PLK1 MKI67 KIF2C BAG3 BYSL IPO4 SLC29A2 KIF20A SHMT1 MRTO4 RPUSD2 KIF15 NEFH ESPL1 ATAD2 CD320 STEAP3 ALAD AGAP1 ORC1 EXO1 CDC6 NCAPH ZNHIT2 LARS2 DGCR11 MYO19 MCM5 CENPE AOC2 KRT13 PRC1 LLPH GEMIN4 NUP155 DLGAP5 ASNS EPB41 KIF5A COLEC11 AGFG2 down
## RPS14_DN.V1_UP 0.0019724 0.0092975 0.4420395 2.165932 0 182 CRIM1 SESN1 PID1 SEMA3D COLEC12 ANKRD1 SH3GL3 CACNB4 ACKR4 RCBTB2 DCN TM6SF1 KCTD12 BST1 FRY SLC31A2 CTSG PTPRG PTGER4 VWF ST3GAL6 RASAL2 CLEC7A GNAZ EMP1 ACTA2 F5 KMO ENPP2 ARHGEF3 HEY1 RIN2 ZMAT3 NCF2 P2RY14 IGFBP7 VNN1 BCL2A1 CLEC2B JAG1 RGL1 PLK2 DMXL2 MNDA EVI2A ANXA3 ATP8B1 CEACAM8 LY86 CASP1 CCL2 ATP8B4 CCNA1 SIRPA KYNU TYROBP PTPRO GJA1 TFEC IL1B ELANE GPNMB GPR137B MAF PROM1 EVI2B CTSS CSTA AZU1 LPXN HCK ITGAM GPR183 C3AR1 CR1 TRIM22 CROT SMAD3 SNTG1 ANXA6 CD69 LY96 PILRA LY75 ADA ADAMTS6 CALB1 FLVCR2 F13A1 up
## KRAS.KIDNEY_UP.V1_UP 0.0020121 0.0092975 0.4693503 2.162233 0 130 CAB39L GPM6A PLSCR4 SORBS1 NRN1 ALDH1A1 ASPA TMEM100 PECAM1 SOBP PLP1 SPARCL1 A2M RAPGEF4 CA2 FAM153B ATP1A2 KCNA5 METTL7A PEG3 CPEB3 DNM3 ST3GAL6 GPRC5B AK5 CDR1 SFRP1 TMOD1 EMP1 PLCL1 RNLS ZNF536 HEY1 EPB41L3 PELI2 RELN AQP4 SV2B GATM PCDH9 MEF2C NSG1 CHGA GABRB1 TRIB2 TCEAL2 NEBL NRXN1 ETV1 NME5 NDN up
## STK33_UP 0.0020325 0.0092975 0.4193382 2.151706 0 263 CYBRD1 APPL2 PID1 CD36 ZEB2 STX12 FABP4 DOCK4 C20orf194 DYNC2LI1 LPAR6 TTLL7 CXCL3 OTUD1 NLRC4 OLR1 CREBRF VSIG4 IL6ST PPP1R17 STAM2 KITLG SOS1 KLF6 GNPDA2 DAAM1 NUAK1 EMP1 MAP4K3 HBP1 AQP9 SGK1 SLC12A6 KMO MTMR9 WDR19 SLC38A6 RIN2 GNG11 NCF2 CFL2 GPR65 P2RY14 USP53 HMOX1 C5AR1 SNX16 BCL2A1 SAMD8 CLEC2B BBS12 GPR34 MMP1 CDC37L1 RNF149 NAMPT MTSS1 SETBP1 MFAP3 CD101 HNMT ARL5B KCNJ2 MAFF TRIM23 KIAA1841 RNF141 TLR1 AUH RND3 SOCS6 CRK JUN KYNU ZMYND11 BTBD7 OSTM1 FGL2 TYROBP VWA5A GPRIN3 PTPRO GJA1 ANKRD12 ZBTB6 EGR2 TFEC IL1B RAB12 TFPI GPR137B THBD SYNJ1 IL1A ANXA1 ADAM28 NCEH1 SULF2 RTN1 SIPA1L2 PPBP KBTBD8 ATXN1 GLCE ST20 GAN MYOZ2 MIR22HG ZCCHC14 ABHD2 ADM GLIPR1 FOS PPP1R15A PPP3R1 WNT5A LRRC25 ARID5B DUSP1 HBEGF CSRNP1 JUNB CPEB2 PHLDA1 up
## STK33_NOMO_UP 0.0020284 0.0092975 0.4077799 2.096861 0 267 CAB39L APPL2 PID1 RAB8B ZEB2 STX12 FABP4 DOCK4 DAB2 C20orf194 TM6SF1 CXCL3 A2M MAP3K8 OTUD1 HECTD2 OLR1 CREBRF IL6ST STAM2 KITLG SOS1 KLF6 GNPDA2 CTTNBP2NL EPAS1 CLEC7A NUAK1 LACC1 ULK2 PTX3 EMP1 MAP4K3 HBP1 AQP9 SGK1 SLC12A6 KMO KCTD3 MTMR9 DCSTAMP PTBP2 WDR19 JAKMIP2 RIN2 GNG11 CFL2 P2RY14 USP53 HMOX1 C5AR1 CLEC2B BBS12 MMP1 CDC37L1 RNF149 NAMPT NR1D2 MTSS1 SETBP1 HNMT CREBL2 ARL5B CD300C KCNJ2 IL1R1 MAFF TRIM23 TLR1 AUH RND3 TPSAB1 CRK JUN KYNU ZMYND11 BTBD7 OSTM1 IL1R2 VWA5A GPRIN3 PTPRO GJA1 ANKRD12 SIGLEC9 EGR2 TFEC KCNJ15 TBCEL IL1B NRAS CXCL6 RAB12 GPNMB GPR137B THBD SYNJ1 IL1A SLC24A3 ADAM28 NCEH1 SIPA1L2 PPBP KBTBD8 UEVLD GAN MYOZ2 MIR22HG ZCCHC14 ABHD2 GLIPR1 C3AR1 FOS PPP1R15A PPP3R1 EFNB2 WNT5A LRRC25 ARID5B up
## CSR_LATE_UP.V1_UP 0.0019960 0.0092975 -0.4361586 -2.090936 0 156 EIF3B DTYMK NOC2L MYBL2 C19orf48 FARSA UBE2C ASB6 TUBA4A IMP4 POLD1 LMNB2 YIPF3 TUBG1 CDK5 SRM PSMD2 UHRF1 POLR3K KIF22 PREB FEN1 NKX2-1 NUDC CDCA8 KRT18 BIRC5 UMPS PAICS DRAP1 MAZ ILF2 TOMM34 GYS1 FOXM1 PSMC3 PRMT5 PA2G4 PDCL3 RRM2 ZWINT CLSPN FANCA EIF5A ANLN CASP2 CDC6 AHSA1 NUF2 DNAJB11 YEATS4 MET CIAPIN1 KISS1 EZH2 SHCBP1 CKAP2 ZNF367 NMB down
## PIGF_UP.V1_UP 0.0019569 0.0092975 0.4155657 2.037146 0 181 REV3L TGFBR3 MMRN1 RUNX1T1 ROR1 STON1 ABCA8 RPGR FABP4 RAP1A IL1RL1 RCBTB2 STXBP3 NEK7 NEK1 CPA3 IREB2 SCAF11 IL6ST PGAP1 STAM2 SOCS5 TDRD3 HS2ST1 BACH1 OSBPL8 CDC27 RARB CRYBG3 RNF13 DZIP1 ADAM9 CREB1 TMED5 MKLN1 KIAA0040 SLC38A6 NAP1L3 MICU2 CLEC2B STK38L BCLAF1 CFH F11 CCPG1 MTM1 MAPK6 LTBP1 ACADM PRKACB ANGPT2 SPRYD7 TSPAN8 MAP2K4 THSD7A RFK DMTF1 SUCLA2 BAZ2B IRAK1BP1 LPCAT4 NUCB2 UFL1 XIST NAT1 CALB2 TOPORS AGL SACS LRRC17 GMFB GJA4 LARP4 ATP13A3 ITSN2 NRCAM DCP2 PEX1 up
## ATF2_UP.V1_DN 0.0020080 0.0092975 0.4009981 1.948952 0 171 PTGFR REV3L PLSCR4 SVEP1 CYBRD1 PID1 SGCG IL33 ROR1 STON1 CD302 ANXA10 ABCA8 PLN MFAP4 ACVR2A SLIT3 EFEMP1 TCF21 FGF7 KCTD12 CDH13 FRY HS2ST1 SMAD6 GPRC5B PTX3 ITIH5 CXCL12 AADAC PER3 CSGALNACT1 SLC39A8 HMG20A CCP110 NFIB ARHGEF3 AFF1 EDIL3 PELI2 PTGIS PDPN ID4 GAS1 CFH MN1 ST6GALNAC2 KCNJ2 EDNRA IL1R1 SP1 CCL2 SFRP4 FMOD ATP8B4 IQCG up
## RB_DN.V1_UP 0.0019920 0.0092975 -0.4190431 -1.942955 0 123 MAPK13 TIMELESS NME4 MAN1B1 TTI1 UBE2T DCXR TUBG1 MCM7 AHCY STUB1 TNFRSF18 PDXP DNMT1 SLC35B2 POLD4 CTC1 GRB7 TNFSF9 MDM2 TMEM54 GNB1L RRM2 PMM1 DDIT4L EPHX1 ZSCAN22 RAD54L TGM1 SIVA1 SLBP AAAS SLC2A8 PMS2 VPS16 CCDC88C DSN1 UCK1 BBC3 SLC25A42 CLN6 CCNE1 DNA2 NXT1 ACOX3 NUMBL IL36RN STMN1 CCNE2 OVOL2 NUDT5 PRKAB1 MCM6 PLXNB2 down
## PDGF_ERK_DN.V1_DN 0.0019881 0.0092975 -0.3994185 -1.885499 0 141 IDUA DHX34 SNAPC4 CDK2AP2 FBXL18 PRCC FADD PITPNM1 MOGS TBCC MNT SUOX SCO2 DTX2 PPP6R1 PRSS16 KDM2A TRAIP ZNF500 ZNF202 SAC3D1 APC2 CCNF ZSCAN9 GIPC1 CIC PPRC1 FAM89B MBD3 NEFH MAD2L1BP BRPF1 HINFP DUSP8 NCAPH2 FAM50B EFNA3 ARHGEF16 BCL9 TBKBP1 C2CD2L PISD SLC3A2 ZNF324 ARF6 KRT13 MAFG FRAT2 PDE4A down
## RB_P107_DN.V1_UP 0.0019802 0.0092975 -0.4035780 -1.884794 0 128 ANAPC11 SAMD10 RPL39L WDR90 POLD1 LGALS3BP E2F1 TUBG1 MCM7 ASF1B CDC25B MCM2 FEN1 INCENP IPO9 CCNF CHAF1B SYCE2 LIG1 POLE TMEM45B NAA40 GINS4 PRDX4 RRM2 LYPD1 FANCA KIF4A TCFL5 BEX2 BLVRB PTMA SIVA1 SLBP NCAPH DHFR NCAPD2 SNCG MCM5 PRC1 CCNE1 DCLRE1A DNA2 HMCES NXT1 SPIRE2 GTSE1 MAD2L1 STMN1 CCNE2 LCK TSSC4 PAQR4 CENPH MCM6 GMNN CDC45 ORC6 EFS down
## CSR_LATE_UP.V1_DN 0.0020121 0.0092975 0.4046051 1.863960 0 130 PDE5A SVEP1 ABCA6 MAMDC2 ACKR4 DYNC2LI1 MME SCML1 INSIG1 HMGCS1 EXOC6 CLEC3B ACVRL1 GFRA1 STARD4 LONRF1 PAMR1 LPAR3 MRGPRF BACH1 TCEAL7 DENND2A SGIP1 GYPC CDC42EP2 MSMO1 RNLS GLT8D2 DKK2 ROBO3 HHEX TMEM119 GAS1 ADAM17 CFH C1orf115 IDI1 GAS6 ERMP1 RASSF2 HMGCR CCL2 OLFML2A TBC1D2B NTN4 GSN SOD2 IL1B ANGPTL2 LDLR up
## HOXA9_DN.V1_UP 0.0020243 0.0092975 0.3761475 1.823076 0 170 SESN1 STX12 PECAM1 TPK1 RCBTB2 JAK2 LPAR6 FBXL5 UHRF1BP1L GALC DYNLT3 KLF4 BST1 AGTPBP1 FRY DICER1 ZFYVE16 SLC26A2 PTGER4 RNF11 SAMHD1 SLC22A4 ST3GAL6 ADAM9 ACTA2 PIK3R3 MS4A4A SGK3 ARHGEF3 ZMAT3 NCF2 IFT74 SCHIP1 PLK2 FAS MNDA TMEM251 SNX10 CSNK1G3 CLK4 UGGT2 SLC46A3 CCNA1 SLC35D2 OSTM1 ZCCHC2 FGL2 TYROBP ERLIN2 IL13RA1 CRY1 ACYP2 NGRN SERPINB8 TFEC CXCR2 GPR137B THBD CRISPLD2 CYLD CD86 ATXN1 NDFIP1 MAP4K4 GLIPR1 GPR183 FOS up
## E2F3_UP.V1_DN 0.0020202 0.0092975 -0.3870174 -1.815396 0 137 CDH15 PC KRT80 NAT9 TBRG4 SNAPC4 PVT1 FBXL19 POLR1A SPTB AXIN1 URB1 PPAN RAB43 MARK2 MRPL55 ZNF646 CBX3 SNHG3 NT5C EHMT1 GALNTL6 SPRR1B LRRC8E ADM2 CBLC TMPRSS6 WASH3P BYSL POP1 STXBP5L ZNF3 RNF215 EIF3CL STK40 PMAIP1 PLAT EREG ADAM8 UTS2R ZFAS1 NRL FBXO27 INTS7 SH2D2A SH3TC1 KIR2DL4 ANKRD46 SOX1 NR6A1 ZBTB49 PPARD NKX6-3 RUSC1-AS1 LIF IRGC S100P CIITA down
## PRC2_EZH2_UP.V1_UP 0.0019608 0.0092975 0.3719119 1.814717 0 176 MTMR10 SERPINB2 KCNA1 IL33 DMD PRKG2 RGCC TMEM100 IL1RL1 CORO2B MCTP1 SCML1 PTPRB TTLL7 PAQR5 CCDC68 GPM6B KLF4 COL4A6 KCTD12 CDH13 PKIA FXYD6 SLC14A1 CDADC1 PAMR1 NPC1L1 FOLR3 ABLIM3 SLC2A3 RASL12 SLC5A7 TUB KLF11 PTBP2 DKK2 NR0B2 ART3 CLEC2B TBC1D19 ASPN PRSS3 KCNA2 PCDH9 SETBP1 up
## PTEN_DN.V1_DN 0.0020284 0.0092975 0.3752231 1.797230 0 158 GPM6A SERPINB2 B3GALT5 NRN1 ABCA6 CDO1 TBX3 IL1RL1 ADCYAP1R1 SH3BGRL KCNIP1 HMGCS1 CCDC68 PTEN LIN7A SV2C SLC14A1 SERPINB3 ITIH3 DGKB FOLR3 TPPP3 VIM FGR DUOX2 GNG11 PDC LUM P2RY14 SGCE CPLX2 MATN3 TNR SV2B PRSS3 CCL16 GABRB1 SLC5A4 FCN3 SERPINA10 KRT14 NR3C2 C1QTNF1 MLANA FST HAAO CDH11 ANKRD34C INPP4B CDH22 CLDN14 ST8SIA3 up
## ATM_DN.V1_DN 0.0020161 0.0092975 0.3846744 1.781473 0 132 TEK BMPR2 MS4A2 CXCL3 KCNE1 SULT1E1 CLEC3B ACVRL1 RAPGEF4 RDX DNAH9 STX2 F10 ANGPT4 LPAR3 SCGB2A1 GDNF FER AZI2 WNT2 NTRK2 RHAG TAGLN GPR65 ZNF208 CFH CRYBA1 CYP1A2 PAX1 CES1P1 GTF2A1 PLA2G3 KCNC4 SLC10A2 RASSF9 HAAO IL1RAPL1 CYBB EDN3 SRD5A2 HCRTR1 TFEC CYP2J2 FCN1 AGXT SPTLC2 DSG3 PPARGC1A up
## RAPA_EARLY_UP.V1_DN 0.0019417 0.0092975 -0.3635992 -1.771448 0 167 CBX4 PCSK2 SNAPC4 CIT BRMS1 SNTA1 SEC16A MARK2 ESRRA LGALS3BP YIPF2 BCAT2 STK11 SCO2 GRIN1 HLCS TAF4 ACTR1B DDN SPRR1B OVOL1 NHLH1 ACY1 GPT GBF1 APBA3 ATG2A SF3A2 XRCC1 TROAP IL12RB1 PSMD13 EPHB4 COL9A2 OSBPL2 ZNF3 FLT3LG SNTB1 NCAPH NAGPA PSMA7 LHB NUMA1 DPH1 PISD SYNGR4 KDM4B CHKB MET RNF167 KISS1 BBC3 ABTB2 BCKDK PSD down
## E2F1_UP.V1_UP 0.0019841 0.0092975 -0.3616632 -1.763600 0 173 TK1 PARP1 TAF6 CAD RRP1B CSTF2 ERCC2 PITPNM1 THOP1 EIF6 UBE2T USP39 AURKB FEN1 MCM10 GRWD1 MCM4 CHAF1B NOP56 BOK UBN1 VEGFA PHF12 SLC35E1 MAP3K11 ARHGAP39 MPG BUB1 LPIN2 PSME3 INO80E NOLC1 PACS1 MED20 UPK2 LMNB1 TOP2A HSPBP1 CNIH2 E2F3 SLBP NCAPH AGO2 DNAJC21 DDX46 TRAF3 BOLA3 ARHGAP8 USF2 EZH2 DNAJC2 GRSF1 PRC1 CLN6 UQCC1 DNA2 GPN2 GPR19 FRAT2 DLGAP5 ADCY6 DLX1 DCTPP1 PLK4 ARHGEF1 SLC7A1 CYBA SHBG PAIP2B down
## LTE2_UP.V1_UP 0.0019685 0.0092975 0.3589410 1.754819 0 180 PLAGL1 PROS1 PHACTR2 APPL2 ABCG2 REEP1 CD302 PLCB4 DIAPH2 DAB2 AOX1 SASH1 UHRF1BP1L HMGCS1 CCDC170 FGFR4 FERMT2 KATNA1 ACTG2 SDCBP SLC26A2 PDE8A DPYSL2 PTGER4 PPP1R3C CLMN EPAS1 GTDC1 MEIS2 NUMB SCARA3 BNIP3L KMO RHOQ CSGALNACT1 GPX3 HMGCS2 BACE2 NUDT4 RIN2 MAP3K5 MYO5A C4orf19 PCDH9 C1orf115 RCAN1 RRAGD SECISBP2L IL1R1 PJA2 MGAT4A MBP RPS6KA5 BTG1 EFCAB11 LMO4 DEGS1 KIF13B PIGH up
## CAHOY_ASTROGLIAL 0.0020450 0.0092975 0.4044363 1.752374 0 93 CASP12 OGN SPATA6 C11orf88 INSL6 FBLN5 P2RY1 COL4A6 OMD CD109 GLIPR2 CNN1 ACTA2 LOX ANXA4 SERPING1 CAPS2 TAGLN OMG HMOX1 CCNG1 PCDH17 PRSS23 FAS KIRREL3 CASP1 SUCNR1 FMOD C1QTNF1 TBC1D2B TMEM37 MRPS6 VLDLR GPNMB CCDC96 SLC24A3 ANXA1 LTBP2 ITGBL1 TSPO up
## RAF_UP.V1_DN 0.0019569 0.0092975 0.3531291 1.731075 0 181 CAV1 SGCG GHR PGR PLCB4 EPB41L2 ID2 B3GALNT1 PMP22 JAK2 CTNNAL1 SH3BGRL GALC TMPRSS3 SLC1A1 CCDC170 VAV3 TCF12 APBB2 GFRA1 MYLK KITLG SDC2 NPY1R BTBD3 MPDZ PPP1R3C PALLD SNAP23 FTO TGFB2 SLC39A8 MYB PTBP2 MYO1B SLC16A1 TCN1 PLK2 KDM6A LIN7C WASF3 SPIN1 FAM216A MXI1 HSPB8 RND3 KYNU ARL3 OSTM1 JMJD1C INPP4B MGP PDK3 up
## PRC2_EED_UP.V1_UP 0.0020202 0.0092975 0.3604837 1.730796 0 159 REV3L SEMA6D SERPINB2 PLSCR4 EVI5 DMD ANXA10 C1orf21 IL1RL1 NXPH3 CORO2B MCTP1 USP12 SPON1 SERPINB7 CDADC1 MYH1 PDZRN4 USP46 ARHGAP24 BTBD3 MPDZ BACH1 RASL12 CACNA2D3 MS4A4A ENPP2 PTBP2 DKK2 CDHR2 NR0B2 RNF38 ELF1 ADAM17 GSTA3 ZHX3 MTSS1 BMP2K CCL16 PRSS12 CBR4 KCNQ2 CUBN SLC35D2 OSTM1 NR3C2 NMT2 PTGDS LXN PKD2L1 RGR KCNJ15 BAZ2B CYP1A1 up
## RB_P130_DN.V1_UP 0.0019960 0.0092975 -0.3787019 -1.730409 0 114 TRAF2 TK1 CRLF1 QTRT1 SDF2L1 RGL3 UBE2C SNTA1 OXLD1 TRAF4 LSM4 CRB3 RASD1 EFTUD2 KIF22 NKX2-8 AURKB CUEDC2 ATP2A1 EXOSC2 GFER BIRC5 ELOF1 POLD2 FAM220A MBD3 KIF20A AURKA CHCHD6 ORC1 RUVBL2 RABEPK POLR2I PARS2 CHCHD7 ZNF428 DUSP13 SLC22A3 ZBTB17 GRTP1 ICA1 CDK1 NSMCE1 DCTPP1 CYBA RACGAP1 USP13 SGSM3 SNRPB RIPK3 RAD51D down
## CYCLIN_D1_KE_.V1_DN 0.0020080 0.0092975 0.3512737 1.706171 0 173 CAV1 ANGPT1 CYP2F1 ADH1B BNIP2 EML1 ADARB1 ALDH1A1 PRKG2 GAB1 GRIA1 DNAJB4 PGM5 ACTN2 MYH2 CXCL3 A2M ATF7 ACTC1 PIK3R1 CPA3 CYP2C9 NEDD4 MAPK4 CRISP2 NOS1 PTH1R TUBA1A KLF9 DNAH3 GNAZ GYPC PENK CXCL12 KIAA0040 WTAP RLBP1 PTCRA GYPA PCK1 LIMS1 ADD3 IFNAR1 LRMP UBE3A DAO IL1R1 MXI1 TGM3 ATF2 up
fgsea_plot(fgsea_res$res_c7, pathways_title='C7 immunologic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## -------------------------------------------------------------------------------- ---------- ---------- ----------- ---------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0020877 0.0069576 -0.7114826 -3.516557 0 187 EEF1D ZNF512B SLC25A22 FOXK2 STK25 NOC2L CCS FBXO41 CDK2AP2 MRPL12 TBL3 PRCC TMED9 VPS9D1 QTRT1 BRMS1 SDF2L1 SLC2A4RG PFDN2 TSTA3 GCDH ATP13A1 ABCF3 IRF3 PDAP1 WDR18 TSR3 SART1 PDIA4 NELFB PRPF19 E4F1 RRS1 SSRP1 EXOC7 AP5Z1 SIGIRR NADSYN1 RALY AAMP THOC6 AURKAIP1 SREBF1 GADD45GIP1 TACC3 TP53 U2AF2 RPL37 SPINT2 COPG1 HRAS MRPS2 ANAPC2 SAC3D1 MFSD10 TAF4 UBE2M PGLS DAZAP1 CLPTM1 ST6GALNAC4 POLD2 NFKBIB ADRM1 TRIM28 DRAP1 EDF1 UBE2S BANF1 RBM42 NONO UBN1 APBA3 TMEM259 HMG20B COPS7B POLR2E PAF1 SF3A2 PTBP1 SH3GLB2 SLC39A4 IMPDH2 XAB2 CD7 SNRNP70 DCAF15 UCP2 PTPRCAP OSBPL2 SIPA1 GATAD2A C9orf16 THAP7 RPL36 SNF8 SLC7A5 ERP29 LIMD2 PUF60 CFL1 PTMA RPL11 DNAJC17 PIN1 HNRNPM VPS51 AIP PPP6R2 CDC37 HSPA9 FUS CORO1A SMARCD2 TECR WDR74 RAB1B DGKZ ABHD17A MZB1 TAF1C STARD3 GPS2 RALGDS RPLP2 CDK9 SAFB RPS27 ZBTB17 SNRPF PRPF31 ARF5 MARCKSL1 PDIA3 LRRC41 down
## GSE45837_WT_VS_GFI1_KO_PDC_DN 0.0021097 0.0069576 -0.6429835 -3.167713 0 180 BCS1L NPM3 MZT2A MRPS34 NDUFS6 MZT2B FASTK PSMD4 DAP3 LAMTOR2 SNRNP25 RFXANK PITPNM1 RBCK1 DECR2 TRADD CCT7 LMAN2 LSM7 HSPB1 SHMT2 EBNA1BP2 NIPSNAP1 CD2BP2 CLASRP AUP1 AAMP NUDT1 ETFB AHCY DNPH1 HEMK1 TOR3A ENSA PSMC5 DYNLRB1 UCKL1 ECI1 ARPC1B CLPTM1 C7orf26 NENF NME1 TCF20 HDHD3 DRAP1 EDF1 PLEKHJ1 EPS8L2 GRHPR CYB561D2 NTHL1 PSMB6 RANGRF MPG PSMD13 GANAB ZNF32 MRPS16 PRMT1 MRPL23 DDX49 PFKP ERP29 COX6B1 MPI COPS6 AEN POLR2I PIN1 CDC42SE1 VOPP1 POLR2F SNRNP35 DPM3 FUS PSMD9 SOD1 NUMA1 GNA12 PSMD8 MCM5 DALRD3 ZNF428 COG4 SAE1 MPDU1 RALGDS NDUFA7 ISG20 SNRPF PRPF31 ARF5 TBCA PDIA3 NDUFS7 SLC35C1 STOML2 EIF3K ECSIT ARL6IP4 EIF3I EEF2 CTDNEP1 DFFB UQCRQ SDHC HNRNPF BANP RPS7 XRCC6 SNRPD2 UQCR11 SET UQCRH YARS2 OCEL1 UBE2Z MRPL40 down
## GSE24634_TREG_VS_TCONV_POST_DAY3_IL4_CONVERSION_UP 0.0021186 0.0069576 -0.5990967 -2.952460 0 182 DUS1L ISG20L2 MRPL24 DTYMK FBXO41 PWP2 LONP1 MYBL2 PFDN2 NUP210 NCL PMPCA NVL TSR3 NOC4L CDT1 ATIC IMP4 FAM136A CCT7 NPRL3 LSM4 ODC1 TARBP2 SRM ATP6V0E2 TSFM RNASEH2A HAUS5 NMT1 POLR3K RUVBL1 TACC3 CNPY2 HSPD1 EXOSC2 UBE2M CDCA8 ENO1 CCT2 POLD2 PABPN1 MRPS12 PRKD2 MCM10 ILF2 RBM28 LIG1 HNRNPAB PLK1 NTHL1 POLE MKI67 BYSL FIBP PRMT5 BZW2 PTBP1 SGTA WRAP73 POP7 RPUSD2 NOLC1 CS C1QBP DDX39A NCAPG2 EXO1 MRPL23 CENPF SLC7A5 NCAPH2 SUPT16H NUDCD3 MRPL17 AGO2 HNRNPM GAPDH PMAIP1 MAP4K1 CENPA NUP93 NCAPD3 CRCP CIAPIN1 FUT8 KIF18A DCLRE1A GINS1 SPDL1 CLPP CTPS1 TRAC KNTC1 COX17 EIF3I CTDNEP1 down
## GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0021186 0.0069576 -0.5989938 -2.948856 0 181 CBX4 IDUA ZNF512B NDUFS8 PPP1R14B FOXK2 STK25 GID8 FBXO41 MRPL12 CORO1B PRCC TMED9 CAPN15 PFDN2 RBCK1 BECN1 PDAP1 WDR18 TSR3 SART1 APRT PDIA4 SSRP1 DEAF1 AP5Z1 NADSYN1 RALY THOC6 AURKAIP1 AHCY RNF126 TP53 U2AF2 RPL37 MAP2K2 COPG1 HRAS FBXL15 LRRC47 SAC3D1 MFSD10 DAZAP1 ST6GALNAC4 MRPS15 MVP PABPN1 NSMF RNPS1 ADRM1 DRAP1 EDF1 UBE2S NONO HNRNPUL1 HMG20B SLC52A2 COPS7B POLR2E SF3A2 PTBP1 SH3GLB2 XAB2 UCP2 PTPRCAP ILVBL ZNF580 HNRNPU GATAD2A C9orf16 FCHO1 EDEM2 GTF2F1 SNF8 DDX49 ERP29 LIMD2 CFL1 HNRNPM VPS51 RNF19B CDC37 PKN1 HSPA9 WDR45 SMARCD2 DGKZ STARD3 RPN1 GPS2 SEC61G RPLP2 SAFB SNRPF MCUR1 PRPF31 down
## GSE16385_MONOCYTE_VS_12H_IL4_TREATED_MACROPHAGE_DN 0.0021142 0.0069576 -0.5807637 -2.864238 0 183 TRIM11 RHBDL1 NPM3 NCLN FASTK SNAPC4 RNF31 AP3D1 MLLT6 ATXN2L RPS6KB2 UBE2Q1 CHD4 DENND4B NELFB CACNB3 CLCN7 IL27RA ERGIC1 ABCA7 TRABD TBC1D9B AUP1 PPP1R37 POLRMT TUFM RNPEP GLYR1 SLC5A6 PHRF1 LRSAM1 SH2B1 UCKL1 MIIP MND1 AKT1S1 JOSD2 LASP1 RPS6KA4 TSC22D4 UTP3 FAM20A PTCD1 TOMM34 MEX3D PCYT2 ZNF653 FHOD1 TMEM259 PQBP1 ABCB9 HMG20B CIZ1 MAP3K11 KAZALD1 ZNF777 ARID1A XRCC1 MDM2 SNRNP70 FAM193B STRN4 THBS3 RFX1 ZFAND2B POMT1 CHRNB1 NFRKB GSE1 ZBTB48 LMNB1 CTSA PPP1R12C FCHO1 LRP10 CCDC97 ERP29 MAPK8IP3 STX4 GALT LMF2 RNF19B TESK1 CORO1A MOB3A TATDN2 GPS2 NUP188 LMAN2L PACSIN1 GNB2 UBA7 MRPS35 ZNF384 LIPE down
## GSE37532_TREG_VS_TCONV_CD4_TCELL_FROM_LN_UP 0.0021142 0.0069576 -0.5778487 -2.849862 0 183 EEF1D GPATCH4 YDJC TOP1MT ALG3 C7orf50 SNHG17 BSPRY HDGF METTL1 WDR55 ECE2 RRP1B CCT3 FTSJ3 C19orf48 ATAD3A APRT ATIC SFXN2 DDX56 NOP14 SHMT2 EBNA1BP2 SRM CLUH ZNF239 MPHOSPH10 NOP2 USP39 SRP68 AIMP2 HSPD1 MRPS2 CCT6A EXOSC2 SLC35B2 POLR1B ECI1 TMEM147 ALDH18A1 GRWD1 NOP56 IMPDH1 POLR3E TRMT61A ACY1 GAR1 HSP90B1 PRMT5 SF3A2 GART MUC1 GNG3 PSME3 MRTO4 CDC25A ABHD14A C1QBP DBN1 C12orf45 EXO1 DNAJC11 PRMT1 CDC6 TSR1 SLC7A5 ENDOG AEN FAH TSR2 POLR2I PRDX6 SLC35F2 WDR74 NOP58 PARN DNAJC2 DTD1 COQ4 CCDC58 DANCR ELP5 RSL1D1 MRPL37 MCM8 IRF4 CD70 CTPS1 ECSIT ICAM1 SLC19A1 MRPS27 TXNRD1 TIMM10 down
## GSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_DN 0.0021186 0.0069576 -0.5749488 -2.830482 0 181 TLCD1 NOL6 NPM3 MRPL4 NCLN MAPK13 MRPS34 ABCF2 PDCD11 PUSL1 RRP1 POLR1A METTL1 ALYREF C19orf48 POLR2D FARSA MYBBP1A PPAN THOP1 TIMM50 TRAP1 DDX51 STIP1 NOC4L NPRL3 DDX56 NOP14 UBE2T ACAD9 GPT2 SHMT2 NTMT1 CLUH PCBD1 UHRF1 DPH2 NOP2 RRP9 CHAF1A TIMM44 TOMM40 NUDC POLD2 TNFRSF4 TRIP6 MCM4 TOMM34 CCDC86 GOT1 CDC20 ACY1 CCNB1 SFXN4 SNX8 ALG1 LRP8 TIMM13 CYP27B1 CAMTA2 PA2G4 PLAGL2 LAG3 VDR NEFH ESPL1 AURKA CD320 ZWINT SNRPC URB2 AGK DDX49 PFKP GRAMD4 down
## GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_OLD_DN 0.0021231 0.0069576 -0.5686459 -2.805172 0 186 DPP3 TK1 MRPL12 PPM1G CYC1 RANBP1 CCT3 CSTF2 TRAP1 STIP1 POLR2H MYL6B EIF2B4 LMNB2 EBNA1BP2 TUBG1 CD2BP2 PSMD2 TALDO1 RNASEH2A MCM7 NUDT1 HJURP CDK4 GADD45GIP1 POLR3K AIMP2 AURKB MCM2 FEN1 KEAP1 NUDC BDH1 FANCG NME1 MCM10 PAICS SRPK1 MCM4 TPX2 EMC9 TYMP MRPL11 CCNB1 PSMB6 CEP55 KIF2C IMPDH2 PSMB5 GART TUBA1C KIF20A ATOX1 SHMT1 CDC25A RRM2 KIF15 VDR ESPL1 AURKA ZWINT NCAPG2 PHB TOP2A CENPM CENPF MPV17 KIF4A CDC6 MRPL15 MELK HMMR FAH NCAPH GAPDH SPAG5 ASPM DHFR CENPA SFT2D2 PCK2 GOT2 RFC4 MCUR1 KIF11 SPDL1 NIT2 IRF4 DLGAP5 CTPS1 IDH1 STMN1 down
## GSE9601_UNTREATED_VS_PI3K_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_UP 0.0021186 0.0069576 -0.5779290 -2.802891 0 162 NDUFS8 B4GALT7 CIT CTBP1 SIRT7 RBCK1 IRF3 SRRT OS9 SSRP1 EXOC7 DDX41 SHKBP1 PAFAH1B3 CXXC1 RGS14 TMCO4 RPL38 MAD1L1 MAP2K2 DPP9 MED15 SF3B2 PRRC2B DDX54 DNMT1 MIIP BDH1 CDCA8 SPRR1B BIRC5 CHMP4B SDF4 GIPC1 PSMC4 CCDC12 TPX2 ARHGAP27 ARHGDIA KIF2C DDA1 CSNK1G2 NOSIP PSMB4 ANKRD11 NFKBIE MBD3 NDUFS5 POLR2L PPP1R9B SIPA1 RPL37A LMNB1 MAU2 FLII THAP7 GTF2F1 CCDC97 RCC2 RAB4B PUF60 ZC3H7B MEA1 CDC42SE1 TUBGCP2 CORO1A NCAPD3 RAB1B DSN1 BSG UCP3 MYO18A CKAP2 FRMD8 HNRNPL MED8 FMNL1 RFWD3 RNASEH2C FKBP8 RPL41 RPL28 MCM3 ARL6IP4 RELB PSMB10 TSSC4 IRF9 TICRR ARHGEF1 BRCA1 TRAF1 CYBA SF3A3 SERF2 SORL1 CENPW RPS29 RPL18 TNIP1 down
## GSE16451_IMMATURE_VS_MATURE_NEURON_CELL_LINE_WEST_EQUINE_ENC_VIRUS_DN 0.0021142 0.0069576 -0.5663162 -2.792986 0 183 SLC25A39 TLCD1 CCDC137 BCS1L COASY TBRG4 PFAS PWP2 QTRT1 TRUB2 C19orf48 POLR2D DNAJA3 MTX1 THOP1 XPR1 NSUN2 TRAP1 SLC39A3 FAM136A RRS1 DDX56 TACO1 ACAD9 GPT2 SSRP1 LMNB2 CCT5 CDK5 SRM PCBD1 ZNF239 PCCB SPINT2 ZBTB32 PDIA6 TNFRSF18 TOMM40 DDX54 POLR3H ALDH18A1 ORMDL2 TNFRSF4 ATP1B1 SND1 IMPDH1 CCDC86 RBM19 CLPB POLR1C CCNB1 SFXN4 PIGM LRP8 IPO4 CAMTA2 LAS1L PLAGL2 ATOX1 LAG3 HIRIP3 ARPC1A ESPL1 RAE1 CISD3 ORC1 URB2 CENPM FSD1 HSPBP1 KIAA0100 CREB3L2 TXLNA PTPN7 MRPS18A MAPKAPK3 DHFR SEC11C FUT8 CLN6 MED8 FANCE VPS25 GFPT1 SLC1A5 WDR12 LIG3 SERPINH1 MFN2 down
## GSE18893_TCONV_VS_TREG_24H_TNF_STIM_UP 0.0021645 0.0069576 -0.5708634 -2.784987 0 173 HMBS MRPL4 CHTF18 PUSL1 NMRAL1 MRPL12 CHID1 CBR1 CIT MYBL2 CYC1 CAD RANBP1 C19orf48 BCL2L12 TRAP1 SAPCD2 CDT1 GSS WDR34 POLD1 E2F1 LSM4 CABLES2 AK2 DDX41 UHRF1 ERGIC3 RNASEH2A MCM7 NUDT1 FASN ETFB MCM2 GFER CDCA5 CCNF MRPL41 PRDX2 MCM4 CHAF1B COX6C ILF2 SPC24 PTTG1 SFXN4 TROAP PSMD13 CHCHD2 MLLT11 RNF26 CDC25A KIF15 NDUFB9 FAHD2A FIGNL1 MPV17 PRKDC CDC6 MRPS21 MRPS18A RCCD1 CENPJ BOLA3 PDZD11 PPCDC DCUN1D5 SLC37A4 GINS1 GOT2 RFC4 VPS25 COQ9 C1orf131 NIT2 DARS2 NUP155 TTLL12 HELLS COQ3 KNTC1 BRIP1 EIF3I CCNE2 ACTL6A TICRR BRCA1 RACGAP1 PSMC3IP down
## GSE40274_CTRL_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP 0.0021142 0.0069576 -0.5756313 -2.782654 0 155 WDR4 PYCR1 PUSL1 LETM1 SNAPC4 PVT1 NUBP2 RANBP1 C19orf48 PDAP1 MYBBP1A THOP1 KCNC3 STIP1 POLD1 MRPL55 LSM4 SSRP1 KNOP1 E2F4 RRP12 FASN SLC35B1 RRP9 AHCY DNPH1 SLC5A6 HSPD1 PDXP MCM2 NUDC CDCA5 CCNF BATF NME1 TNFRSF4 PAICS NOP56 DPP7 NOB1 CDC20 CACNA1E RAB11FIP4 PPRC1 MKI67 BYSL PAF1 DMBX1 TNFSF9 POLR2L MAFK RAB17 ELAC2 NEFH DDX31 ESPL1 C1QBP OAS3 URB2 NCAPG2 EXO1 VAC14 CCDC87 EME1 CENPM PFKP AHSA1 TLE3 ACACA PGP RTEL1 RAD54L XYLB RPS19BP1 NCAPH ANO7 HSPA9 ANKLE1 MYO19 HPDL CHPF MRI1 CDCA2 down
## GSE24574_BCL6_LOW_TFH_VS_TCONV_CD4_TCELL_DN 0.0021142 0.0069576 -0.5636242 -2.779709 0 183 PMVK PYCR1 PARP1 PFAS TMED9 FADD MYBL2 MRPL28 THOP1 FKBP2 SHMT2 BCAT2 HAX1 EBNA1BP2 NIPSNAP1 TUBG1 SRM PCBD1 ECHS1 ST14 TM7SF2 CDK4 TP53 CHAF1A TRAIP AURKB MCM2 TOMM40 CCT6A UBE2M BDH1 ECI1 ENO1 UMPS SNRPA MRPS12 MCM4 GOT1 PLK1 IDH2 GSTP1 GGCT AIFM1 IMPDH2 PSMD13 HIRIP3 NEFH ESPL1 AURKA CPOX ZWINT SNRPC YIF1A ORC1 TOP2A CENPF PKM DFFA COMT TXLNA MELK HMMR FAH RAD54L VCP DUSP4 HTATIP2 GAPDH DHFR NCAPD2 CORO1A PLXNA3 TTF2 EZH2 GALE TXN SORD XPOT GINS1 RFC4 SLC1A5 MCM3 GOSR2 EIF3I BUB1B TNFRSF9 CTNNA1 TTK PLK4 down
## GSE21927_SPLEEN_C57BL6_VS_EL4_TUMOR_BALBC_MONOCYTES_DN 0.0021186 0.0069576 -0.5635445 -2.774338 0 181 DPP3 EIF3B ALG3 PDCD11 NOC2L CRELD2 CIT PPM1G UTP14A TUBA3D POLR2D PDAP1 PMPCA POLR2H MYL6B PDIA4 PSME2 PRPF19 DDX56 NHP2 LSM4 NEIL3 ODC1 TUBG1 CLUH DPH2 MCM7 NAT10 HMGA1 ETFB GADD45GIP1 AATF BLVRA PSAT1 MRPS2 NUDC POLD2 SNRPE ALDOA DCPS MRPS12 MCM4 UBE2S EIF3A CLPB THOC5 BYSL POLR2E RNF25 C1orf109 PSME3 POP1 KIF15 DNAAF2 ATAD2 MED20 URB2 FKBP4 PMM2 SMC4 DDX49 SLC7A5 NABP2 MRPL52 MRPS18A MAPKAPK3 POLR2I PPAT SLBP IARS2 PSMA7 PMAIP1 HSPA9 DEF8 GTPBP4 PSMD8 DNAJC2 GRSF1 CLTA NUP188 KIF18A HSPA8 NXT1 SNRPF TTLL12 STOML2 GNL2 ALG8 TIMM8B UQCRQ BUD31 PARP2 XRCC6 SLC25A11 UQCRH TMEM11 MRPL40 ORC6 UTP18 EMG1 RPSA down
## GSE10239_KLRG1INT_VS_KLRG1HIGH_EFF_CD8_TCELL_UP 0.0021645 0.0069576 -0.5645193 -2.765687 0 177 PSMG3 SNAP47 SMG5 HOOK2 TRMT1 TYSND1 NR2C2AP C19orf48 POLR2D EIF2B5 DDX51 ATIC NOP9 SSH3 NHP2 SHMT2 AARSD1 LDHB MRPS7 DNPH1 CUEDC2 DRG2 CHCHD5 JOSD2 DHX30 BATF ALDOA NME1 HDAC10 TRIM28 PFKL ILF2 ETV4 DBH TPD52L2 ATP4A MRPL11 NAT8L ADCK1 TIMM13 TXNL4A NEK6 DHRS13 ELAC2 EIF4A3 COL9A2 ARX FDPS RAE1 DDX39A GLDC ALKBH6 ADCK5 ACAA1 TXNDC2 VAC14 CHCHD1 ESRP1 SPRYD4 ACSF3 RPL36 SLC7A5 HSPBP1 RABEPK PGP RPS19BP1 SIVA1 MED18 RBFA RCCD1 MRPL17 PIN1 SUSD3 FURIN SLC35F2 SIAH2 ZNF428 MRPL44 DTD1 DLX3 down
## GSE21670_UNTREATED_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN 0.0021231 0.0069576 -0.5603968 -2.765190 0 185 TSPAN17 GPATCH4 NOL6 EIF3B PFAS TRMT1 POLR1A EIF4G1 CAD EXOSC5 RANBP1 CCT3 TFPI2 LARP1 TRAP1 ATIC MRPS25 SFXN2 RRS1 NOP14 TACO1 NARF SRM RRP12 NOP2 HSP90AB1 CDK4 SREBF1 AHCY RUVBL1 TP53 HSPD1 POLR1B ENO1 CCT2 POLD2 ALDH18A1 SCFD2 ZDHHC9 PAICS C12orf66 HNRNPAB POLR1C SFXN4 PPRC1 ZDHHC16 BYSL GNL3 IMPDH2 LRP8 RPIA CEACAM1 EPHB4 MRTO4 NOLC1 C1QBP URB2 PHB LMNB1 CTSA TAF8 PAK1IP1 JAK3 IL21R SLC7A5 CISH DHPS APBA2 WDYHV1 GTF3A SRPRB PCED1B PUS7 SBNO2 PPIL1 SOD1 WDR74 MET GTPBP4 DTNBP1 HEATR1 SORD CMTM8 down
## GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_UP 0.0021142 0.0069576 -0.5547231 -2.735810 0 183 DPP3 TK1 BSPRY MYBL2 RPL39L CSTF2 UBE2C UBFD1 RCC1 CDT1 SHMT2 RNASEH2A PPIL2 MCM7 HJURP CDC25B KIF22 AURKB MCM2 FEN1 CDCA8 ACTR1B DAZAP1 CCDC51 BIRC5 FANCG MRPS12 MCM4 TPX2 EMC9 UBE2S MRPL11 LIG1 HNRNPAB PTTG1 CDC20 IDH2 ASL CCNB1 CEP55 KIF2C FIBP BUB1 NTN3 GALK1 RRM2 KIF15 ATAD2 AURKA MED20 ZWINT NCAPG2 EXO1 LMNB1 AGK CENPM CENPF KIF4A SNF8 DDX49 MELK IL2RB DUSP4 SLBP SPAG5 DHFR SLC35F2 CENPA CORO1A TFDP1 CCR8 PPCDC GGCX COG4 CENPE EZH2 ZNF544 ABTB2 DLEU1 ITPR2 CD38 CCNA2 FUT8 PRC1 DCLRE1A GINS1 NDUFA7 RFC4 PXMP2 KIF11 GPR19 CDKN3 C1orf112 TOX4 BRINP2 IRF4 TOP3A DLGAP5 TRAC KNTC1 down
## GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_DN 0.0020877 0.0069576 -0.5517010 -2.726824 0 187 HMBS TK1 DTYMK PFAS ZNF282 UBE2C STIP1 MYL6B LMNB2 TUBG1 TALDO1 THOC6 MCM7 HJURP AIMP2 CHAF1A MRPL20 AURKB MCM2 FEN1 SAC3D1 CDCA8 CCDC51 BIRC5 UMPS FANCG BATF NME1 KIF18B MCM10 PAICS SRPK1 MCM4 TPX2 TYMP LIG1 CDC20 NQO1 ACY1 CCNB1 CEP55 MKI67 KIF2C BYSL FIBP TIMM13 TUBA1C KIF20A SHMT1 PRDX4 RRM2 VDR ESPL1 NCAPG2 FANCA TOP2A CENPM KIF4A TXLNA PTPN7 HMMR FAH RAD54L PUS7 NCAPH SPAG5 ASPM DHFR CENPA RAB38 CDC25C PPCDC MCM5 CENPE KCNK5 GALE TXN SORD PCK2 CCNE1 UQCC1 RFC4 PXMP2 CTLA4 MCUR1 KIF11 CDKN3 LIG3 CCL22 IRF4 CTPS1 IL12RB2 STMN1 CCNE2 DCTPP1 CTNNA1 BRCA1 NUSAP1 RACGAP1 IL2RA CKAP5 C3orf14 CDC45 RAD51D GBAP1 down
## GSE6269_FLU_VS_E_COLI_INF_PBMC_UP 0.0020790 0.0069576 -0.5635954 -2.722440 0 153 SLC4A2 KCTD13 ADAR AP3D1 CAPN15 EIF4G1 IRF7 ATP13A1 IRF3 GTPBP2 LARP1 RNF40 AGRN TYK2 MARK2 LGALS3BP GOLGA2 MOGS TRABD CXXC1 C16orf58 PI4KB GLYR1 PDIA6 CALR CMTR1 CHST12 MX2 NUP62 POLM NBEAL2 ARHGDIA SZT2 ACIN1 GMIP KMT2B ISG15 ZSWIM8 SUPT6H RPN2 STRN4 PSME3 ARPC1A DCAF15 IFI35 TRIM38 DLGAP4 OAS3 GSE1 LMNB1 NCOA6 MAU2 PKM COMT LIMD2 TRIM14 DCTN1 NFATC2IP MLEC POU2F2 PROSER1 ZBP1 GAK HECTD3 KDELR1 RFWD3 UBA7 MTDH SHC1 SMG7 COPS7A DNAJC4 TIAF1 OAS1 MX1 SZRD1 IFI6 ACTB CD74 NRBP1 OGDH NUCB1 BRD2 USP18 down
## GSE43863_NAIVE_VS_LY6C_LOW_CXCR5NEG_CD4_EFF_TCELL_D6_LCMV_DN 0.0021645 0.0069576 -0.5552073 -2.708607 0 173 WDR4 NOL6 PMVK MZT2A TMEM134 NAT9 PPP1R14B FOXK2 CCS AIFM2 FAM86C1 SEC24C METTL1 CEP250 MLLT6 CCT3 SLC35C2 PHLDA2 EIF2B5 NSUN2 RAB40C APRT DECR2 TRAF4 EIF6 SHMT2 HAX1 SPG7 SLC16A14 SIL1 CLUH PHPT1 NADSYN1 ZFYVE19 THOC6 GADD45GIP1 RAB3D DNPH1 PLEKHA8 FBXL15 PEX6 MTG1 FAXC MACROD1 SND1 MCM4 MEX3D OSTCP1 MYO7A GMIP CLPB MPG POLR2A SEC13 PSMB5 PAM16 PA2G4 POLR2L MUS81 TXNRD2 ZNF296 BET1L SNRPC MSTO1 C12orf45 CCNL2 HTT NDUFB10 ZNF274 ENDOG BCKDHA MLLT1 ZNHIT2 SDF2 PNMA2 GCAT NLRX1 DPM3 down
## GSE22886_UNSTIM_VS_IL2_STIM_NKCELL_DN 0.0020877 0.0069576 -0.5451374 -2.694383 0 187 NOL6 P4HB ABCF2 CDK2AP2 CRELD2 RANBP1 TUBA3D STIP1 CDT1 POLR2H CCT7 RRS1 SHMT2 LMNB2 EBNA1BP2 TUBG1 MCM7 CDK4 FASN NUP107 SCLY TP53 HSPD1 MCM2 FEN1 CCT6A EXOSC2 UBE2M ENO1 CCT2 SMARCB1 POLD2 ALDH18A1 NME1 MCM10 PAICS TRIM28 GRWD1 MCM4 UBE2S RAD23A ARHGDIA HNRNPAB CDC20 PPRC1 GGCT BYSL IMPDH2 PSMB5 IPO4 TUBA1C PA2G4 POP1 CDC25A ESPL1 FLT3LG DDX39A EXO1 DHCR7 PAK1IP1 PKM CDC6 CISH ACACA PTPN7 HMMR DPP4 MRPL17 CDC37 MLEC HSPA9 NUP93 TFDP1 DDOST RBM14 SHCBP1 NUP188 XPOT PRC1 CLN6 DCLRE1A MRPL3 RFC4 SMG9 MCUR1 SLC1A5 WDR12 AUNIP CTPS1 STOML2 ASNS PRPF4 down
## GSE24634_TEFF_VS_TCONV_DAY7_IN_CULTURE_UP 0.0020790 0.0069576 -0.5425867 -2.690768 0 192 TK1 DTYMK SNHG17 PWP2 PPM1G TIMELESS UBE2C CDT1 PNKP NEIL3 LMNB2 MCM7 NUDT1 HJURP RNF187 TACC3 KIF22 MCM2 FEN1 CHST12 CDCA8 FANCG TNFRSF4 DCPS SRPK1 MCM4 TPX2 MRPL11 PTTG1 CDC20 PLK1 IDH2 HNRNPUL1 CCNB1 CEP55 KIF2C FIBP STK39 KIF20A LAG3 SHMT1 RRM2 KIF15 VDR ESPL1 AURKA SIRPG CAPN2 PMS2P5 ZWINT MRPS16 CENPM CENPF KIF4A MCCC2 POLQ CREB3L2 DEF6 MELK HMMR RAD54L SYNGR3 IL2RB DUSP4 NCAPH TTC31 NDC80 ASPM CENPA TFDP1 CCR8 CDC25C CENPE ABTB2 HMGB2 CD38 CCNA2 FUT8 CXCR3 PRC1 CCNE1 DCLRE1A RFC4 PXMP2 CTLA4 KIF11 VIPAS39 MAD2L1 DLGAP5 CTPS1 HELLS KNTC1 STMN1 CDK1 CSF2 PLK4 TSPAN5 NUSAP1 RACGAP1 OLA1 MCM6 SNRPD1 STAU2 GMNN CKAP5 CDC45 CCR3 STIL down
## GSE19888_ADENOSINE_A3R_ACT_VS_A3R_ACT_WITH_A3R_INH_PRETREATMENT_IN_MAST_CELL_UP 0.0021645 0.0069576 -0.5512657 -2.689378 0 173 TSPAN17 DTYMK PUSL1 AIFM2 MRPL12 SNRNP25 CAD RANBP1 CSTF2 REEP6 COMTD1 MTX1 SAPCD2 NOC4L GSS WDR90 WDR34 E2F1 ZNHIT1 LSM4 RMI2 BCAT2 AK2 POC1A TMEM177 ROMO1 CHRNA5 INCENP C16orf91 CCNF SNRPA RRP36 PAXIP1 BTBD6 E2F2 SPC24 FBXO44 PLK1 AQP3 RASSF7 PSMD13 CHCHD2 MLLT11 KIF20A LAPTM4B RNF26 EIF4A3 FDPS C1RL FLT3LG VAMP8 MRPS16 ARHGEF39 DPAGT1 DHPS PSPH RHOBTB2 SYNGR3 GSTZ1 CENPO CHCHD7 DSN1 CDC25C PPCDC C3orf18 FAM111B CENPE MRPL44 TRIM47 LSM10 CLN6 VPS25 TCEA2 RNASEH2C C1orf131 NIT2 DHODH IMPA2 DARS2 MRPL37 COQ3 STOML2 ASNS KNTC1 down
## GSE21360_SECONDARY_VS_TERTIARY_MEMORY_CD8_TCELL_UP 0.0021231 0.0069576 -0.5443892 -2.686203 0 185 RECQL4 TK1 LETM1 TBRG4 HDGF MRPL12 GMPPA TSTA3 STAP2 DNAJA3 MYBBP1A MTX1 BMS1 PSME2 EIF6 PRPF19 POLD1 NOP14 LSM7 LSM4 PKMYT1 PUS1 JTB TRIB3 TUFM GADD45GIP1 SF3B2 TOMM40 UMPS ALDOA ORAI2 UTP3 MRPL11 GOT1 MIS18A PPRC1 RANGRF MKI67 COA3 GNL3 PTBP1 PAM16 POP7 PSMD13 PLAGL2 GINS4 PSME3 CS DNAAF2 RAE1 CPOX MRPL23 PMM2 KIF14 GPI MRPS18A GEMIN2 KPTN HNRNPM PMAIP1 DDX46 TTF2 SEC23B NUP188 NDUFS3 PPIH GOT2 REEP4 CLPP UQCRFS1 ELP5 DNPEP NIT2 DHODH CD3EAP NCKIPSD NDUFS7 ASNS COX17 ACO2 TIMM8B UTP6 DCTPP1 HTRA2 TRAF1 PARK7 ACTB SNRPD2 UQCRH down
## GSE369_IFNG_KO_VS_WT_LIVER_DN 0.0021097 0.0069576 -0.5450252 -2.685113 0 180 DUS1L HMBS PCP4 TBL3 C8orf82 HSPA5 UTP14A EIF4G1 WDR55 MLLT6 NR2C2AP EARS2 PDAP1 FARSA KCTD5 PMPCA NME4 WDR18 FKBP2 EIF6 NPRL3 DDX56 MRPL55 FPGS ODC1 CLUH NOP2 HSP90AB1 RUVBL1 AATF TMEM238 AIMP2 MRPL20 PDXP TIMM44 PSMC5 TOMM40 C1orf122 FOXRED1 DRG2 DYNLL2 MRPS15 RRP36 SNHG12 TUT1 SND1 PDCD2L MRPL11 PCYT2 G6PC3 MECR G6PD YIF1B ALG1 RPIA TIMM13 HDLBP RPUSD2 PNPO CDC25A CS C1QBP DNAJC11 MRPL23 PPIF CHCHD1 CACYBP AKAP1 TMEM160 ENDOG DNAJB11 CORO2A PFDN4 TRMU down
## GSE360_L_DONOVANI_VS_T_GONDII_MAC_DN 0.0020833 0.0069576 -0.5431430 -2.684556 0 188 PC TELO2 ALG3 MRPL12 NIT1 FADD MEN1 HGS IRF7 TFAP4 NME4 TCF3 RCC1 TRAP1 POLR2H CCT7 NHP2 ODC1 TARBP2 OVOL3 RALY ST3GAL5 TUFM FASN AATF AIMP2 SPINT2 HRAS TIMM44 MCM2 FEN1 CHERP SAC3D1 MGRN1 BIRC5 TMEM147 POLD2 SNRPA ILF3 ADRM1 PRDX2 TOMM34 TYMP NONO GBF1 HAGH BYSL RAD9A LPAR2 SGTA SHMT1 PTPRCAP FDPS GAA CPOX ZWINT DNAJC11 SCAP CDH1 MRPL23 C9orf16 CPNE1 FLII SMURF1 MCCC2 PFKP RUSC1 FAM3A MAPKAPK3 POLR2I SIVA1 GSTZ1 PMAIP1 NAP1L4 EZH2 SLC37A4 NDUFS3 NMB SAFB RFC4 GAK SNRPF CCT4 SCN9A UQCRC1 PEX5 ACD MX1 PPFIA4 FAM13A ARHGAP22 GNB5 KCNQ1 HSF1 SNRPD2 SF1 down
## GSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_24H_CD4_TCELL_DN 0.0021142 0.0069576 -0.5440149 -2.682999 0 183 FLAD1 EFNA4 TK1 PPP1R14B DTYMK MRPL12 SNRNP25 FADD TXNDC17 SDF2L1 FTSJ3 DNAJA3 MTX1 TIMM50 LSM4 CDK5 ZNF239 PHPT1 RNASEH2A ETFB DNPH1 CCDC124 FEN1 SLC25A15 CCT6A ECI1 ARMC6 BIRC5 DESI1 SCFD2 DCPS NLE1 SND1 PAICS SRPK1 CHAF1B TPX2 ACY1 GAR1 GSTP1 COA3 AIFM1 PAF1 ZNF787 ATOX1 HIRIP3 PRDX4 MED20 RUVBL2 LMNB1 MRPL23 CENPM PRELID1 HDDC3 TPRN MRPS33 MRPL52 MRPS18A NUBP1 MEA1 POLR2F ASPM PPIL1 CENPJ SF3B3 PAM MRPS28 PSMD8 MCM5 EZH2 SLC37A4 RBM14 SMKR1 CCNA2 ZNF367 GOT2 VPS25 THYN1 CLPP IMPA2 OGFOD2 CTPS1 STOML2 ASNS BRIP1 CREB3 SLC19A1 WRAP53 PSMB2 PSMB10 ACTL6A SH2D2A SLC7A1 down
## GSE36527_CD69_NEG_VS_POS_TREG_CD62L_LOS_KLRG1_NEG_DN 0.0021142 0.0069576 -0.5431618 -2.678791 0 183 DUS1L ANAPC11 WDR4 ZNF212 RRP1 FAM207A B4GALT7 PYCR2 CORO1B PPM1G PSEN2 PRPF6 TSTA3 NUDT16L1 PITPNM1 RHOT2 PKP3 NME4 RAB40C NELFB STAT6 TRAF4 TBC1D10B ALKBH4 E4F1 ERCC3 MLST8 TBCC MNT STK11 SIGIRR ZFYVE19 RNPEP WDR45B COPG1 GRAMD1A SH2B1 CCL25 CHST12 CLCF1 ACADVL UBAP1 NUP62 ZNF764 SNRPA WIPI2 PABPN1 TUT1 CCDC12 PHF23 LLGL2 CDC34 CNPPD1 MAF1 GUK1 CYTH2 TMEM222 COMMD4 FAM89B RPP25L ZFAND2B DCAF15 KCTD2 SPSB3 ZBTB48 CTDSP2 ACVR2B TMEM160 CDK11B PGP CDC42SE1 NISCH SMARCD2 CHKB UCK1 MKNK2 CTSW CXCR3 MRI1 down
## GSE15930_NAIVE_VS_48H_IN_VITRO_STIM_CD8_TCELL_DN 0.0020877 0.0069576 -0.5409087 -2.673482 0 187 DPP3 EIF3B DTYMK MRPL12 LONP1 UQCC2 ITPA PDAP1 FARSA EIF2B5 UBFD1 MRPS25 EIF6 POLD1 UBE2T ZNHIT1 CPSF4 TMEM208 MCM7 CDK4 FASN AHCY KIF22 PDIA6 PSAT1 HSPD1 UBE2M ELOF1 DYNLL2 NUP62 CCNF SSNA1 POLD2 MRPL27 ALDOA MRPS12 RNPS1 MCM10 PRDX2 PFKL UBE2S BANF1 PHF23 MRPL11 CDC34 G6PD COA3 SEC13 TIMM13 GART NDUFB7 PDCL3 PRDX4 RRM2 SSR2 LRRC59 RUVBL2 PRELID1 PKM CDC6 NCAPH2 MRPS33 NUBP1 NCAPH PSMA7 HTATIP2 ASPM HSPA9 NUP93 TFDP1 MRPL51 EZH2 SEC23B BSG HMGB2 PRC1 KIF11 PRPF31 GPN2 SFXN1 CLPP MAD2L1 MARCKSL1 STOML2 COPS7A STMN1 COX17 PGD TIMM8B HSPA4 PSMB7 TTK down
## GSE41867_DAY6_VS_DAY8_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN 0.0021231 0.0069576 -0.5397741 -2.663431 0 185 DUS1L SLC25A39 JMJD4 RCE1 MTG2 GPS1 NOC2L HSPA5 TIMELESS EXOSC5 LYPLA2 EIF6 ZNF213 LSM7 BLOC1S4 NCOA5 CCT5 RPAP1 SNHG7 TMEM177 CDK4 FASN SLC35B1 CLDN7 AHCY AIMP2 DNPH1 UBE2I EEFSEC MCM2 DYNLRB1 NUDC ALDH18A1 NME1 ORMDL2 NLE1 CRELD1 PAICS SRPK1 UTP3 NOB1 SYCE2 RAD23A MRPS26 HAGH PPRC1 POLR2E C19orf53 BZW2 POP7 PSMD13 YWHAG TNFSF9 POP1 TRMT112 DDX39A NDUFB9 PAK1IP1 SPRYD4 DDX49 COPS6 C1orf50 MRPL52 AEN DNAJB11 GSTZ1 AAAS TRMU MRPL17 HNRNPM LARS2 SOD1 WDR74 DNAJC2 MED29 TBC1D10A NUP188 CAND1 HSPA8 PCBD2 MCM3 CD3EAP NDUFS7 COPS7A SPAG7 COPB2 TIMM8B down
fgsea_plot(fgsea_res$res_msg, pathways_title='All signatures', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0019763 0.0107056 -0.7114826 -3.518626 0 187 EEF1D ZNF512B SLC25A22 FOXK2 STK25 NOC2L CCS FBXO41 CDK2AP2 MRPL12 TBL3 PRCC TMED9 VPS9D1 QTRT1 BRMS1 SDF2L1 SLC2A4RG PFDN2 TSTA3 GCDH ATP13A1 ABCF3 IRF3 PDAP1 WDR18 TSR3 SART1 PDIA4 NELFB PRPF19 E4F1 RRS1 SSRP1 EXOC7 AP5Z1 SIGIRR NADSYN1 RALY AAMP THOC6 AURKAIP1 SREBF1 GADD45GIP1 TACC3 TP53 U2AF2 RPL37 SPINT2 COPG1 HRAS MRPS2 ANAPC2 SAC3D1 MFSD10 TAF4 UBE2M PGLS DAZAP1 CLPTM1 ST6GALNAC4 POLD2 NFKBIB ADRM1 TRIM28 DRAP1 EDF1 UBE2S BANF1 RBM42 NONO UBN1 APBA3 TMEM259 HMG20B COPS7B POLR2E PAF1 SF3A2 PTBP1 SH3GLB2 SLC39A4 IMPDH2 XAB2 CD7 SNRNP70 DCAF15 UCP2 PTPRCAP OSBPL2 SIPA1 GATAD2A C9orf16 THAP7 RPL36 SNF8 SLC7A5 ERP29 LIMD2 PUF60 CFL1 PTMA RPL11 DNAJC17 PIN1 HNRNPM VPS51 AIP PPP6R2 CDC37 HSPA9 FUS CORO1A SMARCD2 TECR WDR74 RAB1B DGKZ ABHD17A MZB1 TAF1C STARD3 GPS2 RALGDS RPLP2 CDK9 SAFB RPS27 ZBTB17 SNRPF PRPF31 ARF5 MARCKSL1 PDIA3 LRRC41 down
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0019881 0.0107056 -0.6674565 -3.511633 0 308 ZNF692 TRAF2 NPM3 ZBTB7B KCTD13 EIF3B ABCC10 INTS1 FBXO46 SMG5 RHBG SNAPC4 SH3BP5L FBXL19 DPH7 FBXL18 USP21 PPM1G ZMYND19 QTRT1 UQCC2 CAPN15 ANKRD13D SRCAP GIGYF1 UBAP2L SMARCA4 PHKG2 ATXN2L TNK2 CUL9 ZMIZ2 ABCF3 ERCC2 MYPOP SRRT FBRSL1 LARP1 SETD1A TCF3 SCAF1 LSM14B RCC1 ZNF598 CUL7 KMT2D ATAD3A SLC39A3 DENND4B AGRN MRPS25 GRIPAP1 TMEM86B MARK2 ZNF316 ZNF646 SLC12A9 PUS1 MOGS ABCA7 SYMPK AP5Z1 TRABD CC2D1B CLASRP GAS5 PHPT1 STK11 ZDHHC24 LRCH4 SNHG3 ATAD3B XPO5 RTKN U2AF2 MAP2K2 GPC2 RANGAP1 HSF4 PDXP CALR CACTIN NEURL4 ZNF202 MIIP CMTR1 DRG2 GFER DAZAP1 ZNF444 ARMC6 TECPR1 NUP62 AP5S1 C7orf26 DDX11 TRRAP HIP1R POLM ILF3 PABPN1 HDAC10 RNPS1 ENGASE SPHK2 EVI5L CIC SETDB1 SPPL2B LLGL1 R3HDM4 FBXO44 SZT2 ACIN1 TBC1D22B APBA3 TMEM259 PQBP1 MEF2D WASH3P PPRC1 TMEM63A KHSRP ARPC5L CSNK1G2 RASSF7 COPS7B PTBP1 LPAR2 TNPO2 MBD3 EPN1 SNRNP70 REXO1 TMEM201 KLF16 ZNF580 ARHGEF11 CDK3 HNRNPU GGA1 PICK1 GATAD2A MSTO1 URB2 FANCA PPP1R12C SRRM2 FXR2 L3MBTL2 HPCA CNTROB GRAMD4 LIMD2 MAPK8IP3 TCHP PIP5K1A ZC3H7B MTOR SBNO2 TRMU DAGLB IL18BP CDC42SE1 KAT8 PPP6R2 RAD54L2 FURIN POLR2F SUPT7L BRD1 TAF1C RANBP3 KCNK5 RBM14 ZNF524 RNF207 CSNK1E down
## LI_AMPLIFIED_IN_LUNG_CANCER 0.0019841 0.0107056 -0.6725150 -3.264170 0 167 EEF1D MDK CRABP2 P4HB PDCD6 CDK2AP2 HDGF HSPA5 SYNGR2 ERBB2 TSTA3 CCT3 SCNN1A ABCC3 UBE2C PHLDA2 SPINT1 NME4 FGB APRT TRAF4 KRT7 LGALS3BP HSPB1 CCT5 HAX1 JTB ODC1 CBX3 TALDO1 SLC22A18 LDHB RPL38 TUFM UGDH UBE2I RPL37 SPINT2 UCHL1 HSPD1 CALR DAP SOX4 PABPC1 ENO1 RPL8 SNRPE ALDOA NME1 ATP1B1 EIF3C AKR1C1 TRIM28 DSP DPP7 RPS10 NQO1 VEGFA EEF1A2 IDH2 HSP90B1 SFN PSMB4 PTPRF MUC1 LAPTM4B SDHA PRDX4 RPS2 RPL37A HPN MSLN RPS20 ERBB3 YIF1A CDH1 TRIM2 PKM PFKP GPI SLC7A5 RPS16 TOP1 AKR1A1 JUP STAT1 CD46 RPL27 RPL30 RPS21 PSMD8 DDOST RPL31 RPL27A RPS27 KDELR1 RPL35 RPL28 ZNF146 MARCKSL1 SPP1 RPL13 CANX CLDN9 RPL7 GALNS PGD TXNRD1 ENC1 CKAP4 PLP2 MALL RPS7 XBP1 SNRPD2 UQCRH down
## chr17q25 0.0020000 0.0107056 -0.6426942 -3.219196 0 202 DUS1L ANAPC11 CBX4 CCDC137 NPLOC4 SLC38A10 TMC6 UBE2O TK1 P4HB PYCR1 NAT9 FOXK2 CHMP6 GPS1 RPTOR CBX8 LRRC45 OGFOD3 CCDC57 MRPL12 RFNG SLC25A10 EVPL CSNK1D SYNGR2 ALYREF HGS TBC1D16 GGA3 SIRT7 ENDOV PPP1R27 ASPSCR1 TSEN54 RNF213 CANT1 RAC3 RECQL5 OXLD1 MRPL38 LGALS3BP NARF B3GNTL1 DCXR CARD14 FN3KRP EXOC7 COG1 ZNF750 RPL38 NT5C FSCN2 ARL16 FASN SRP68 MRPS7 WDR45B TMEM104 GPRC5C NPTX1 BIRC5 TSPAN10 FN3K SGSH AFMID ENGASE SAP30BP TBCD TRIM65 FDXR FBF1 LLGL2 PCYT2 ARHGDIA RHBDF2 UNK FADS6 HID1 GALK1 MIR4730 RBFOX3 CD7 TNRC6C-AS1 NARF-IT1 EIF4A3 KCTD2 GAA CDK3 PGS1 LINC00482 USH1G NUP85 ARMC7 RAB40B RPL9P29 SNORD1B RPL31P7 SLC39A11 UBALD2 MYADML2 MIR4525 SNHG16 TEN1-CDK3 SLC26A11 BAHCC1 TRIM47 UTS2R MIR4316 MAFG TMC8 WBP2 ZACN BAIAP2 MIF4GD RNF157-AS1 SLC16A3 MIR1250 SECTM1 GALR2 AANAT down
## CAIRO_HEPATOBLASTOMA_CLASSES_UP 0.0019920 0.0107056 -0.5782584 -3.207940 0 560 ZNF696 EEF1D NPM3 SNRNP200 NCLN P4HB EIF3B STK25 PARP1 ABCF2 PDCD11 GPS1 NR2F6 DTYMK TBRG4 PFAS CIAO1 MRPL12 DDX27 GTF3C2 UTP14A PRPF6 RFXANK TIMELESS CYC1 CAD RANBP1 SMARCA4 CCT3 NUP210 POLR2D FARSA NCL UBE2C MYBBP1A RCC1 TRAP1 MAN1B1 CDT1 APRT ATIC DNMT3A IMP4 MYL6B PDIA4 FAM136A PNKP CCT7 RRS1 POLD1 DDX56 MLST8 PTP4A3 NHP2 LSM4 EIF2B4 SSRP1 PUS1 AARSD1 CCT5 ODC1 THAP4 TUBG1 AP1G2 EPCAM DDX41 ERGIC3 CBX3 RNASEH2A AAMP MAD1L1 MCM7 NAT10 HMGA1 ARID3A HSP90AB1 HJURP CDK4 AHCY RUVBL1 AATF RNF126 MRPS7 CHAF1A KIF22 DGKD PDIA6 HSPD1 AURKB MCM2 CCT6A EXOSC2 DNMT1 CDCA8 DAZAP1 ENO1 CCT2 BIRC5 SMARCB1 E2F5 CCNF RPL8 CPSF6 TRRAP ALDH18A1 NME1 PAXIP1 ILF3 GRK6 APEX1 NLE1 CRELD1 KIF18B MCM10 TRIM28 SRPK1 MCM4 NT5DC2 MAZ NOP56 POLR3E ILF2 TOMM34 TPX2 SAP130 UBE2S TPD52L2 NONO LIG1 CDC20 PLK1 MIS18A MMS19 PQBP1 POLR1C THOC5 CCNB1 CIZ1 GGCT FBL MKI67 KIF2C SMARCC1 DDX42 BYSL PRMT5 CHD7 GNL3 BZW2 SLC39A4 IMPDH2 BUB1 PSMB5 GART IPO4 POP7 TXNL4A CHCHD2 C1orf109 HDLBP KIF20A LAPTM4B RPN2 MAVS GINS4 MRTO4 PRDX4 CDC25A EIF4A3 RRM2 KIF15 NEK2 NOLC1 UPK3A C8orf33 OSBPL2 KPNB1 AURKA C1QBP RPL37A DDX39A GLDC LRRC59 NCAPG2 PHB RUVBL2 PRMT1 FANCA TOP2A CPNE1 CENPF SMC4 KIF4A AGBL5 GTF2F1 KIF14 PRKDC RPL36 CDC6 SNTB1 TSR1 RPS16 NUP85 CREB3L2 MRPS33 MRPL15 SUPT16H WDYHV1 HMMR PSPH PUF60 RPL11 PPAT PUS7 TGS1 TRMU RPL19 PRDX6 NDC80 SPAG5 MRS2 ASPM NCAPD2 CENPA SF3B3 NUP93 ACTR3B EIF5B NCBP2 RPS21 CDC25C GTPBP4 CIAPIN1 RPS6 DDOST EZH2 SAE1 BSG HMGB2 HEATR1 CCNA2 PTK2 KIF18A RPP40 ODF2 PRC1 SEC61G SF3A1 CCNE1 GINS1 SFI1 RFC4 BOP1 KDELR1 RFWD3 KIF11 CCT4 SPDL1 CCDC47 CDKN3 WDR12 RPL28 MCM3 LIG3 CPSF1 EIF3H RSL1D1 MAD2L1 CANX MTDH RPL14 DLGAP5 HUWE1 STOML2 KNTC1 PLIN3 COPS5 PLTP DNAJC4 CDK1 BUB1B EIF4E2 MRPS27 PSMF1 UTP6 TTK TAF12 ACLY HTRA2 IGSF1 PI4KA HSF1 NUSAP1 XRCC6 OLA1 MCM6 SNRPD1 UQCRH CHEK2 RPS3 RPL10A DGUOK GCSH LYRM4 CKAP5 UTP18 EMG1 CENPQ WDR3 SNRPB ENOPH1 NUP205 PABPC4 down
## MORF_CSNK2B 0.0019685 0.0107056 -0.6183210 -3.202966 0 258 SLC4A2 SNRNP200 NDUFS8 EIF3B PDCD6 DAP3 HDGF TBL3 SEC24C CTBP1 PPM1G TMED9 AP3D1 EIF4G1 CYC1 UBAP2L CCT3 CHD4 PDAP1 LARP1 NDUFV1 MAEA ATIC CCT7 NHP2 LSM4 EIF2B4 GPX4 LMNB2 CCT5 HAX1 JTB CBX3 NDUFS2 RALY MCM7 TUFM RNPEP CDK4 MAP2K2 SF3B2 DCTN2 PPP1CA PTOV1 HSPD1 MRPL9 FEN1 CHERP DAP CCT2 TMEM147 SNRPE SNRPA ILF3 EIF3C TRIM28 IMPDH1 COX6C COPE BANF1 RAD23A NONO ARHGDIA HNRNPAB HNRNPUL1 GGCT FBL FIBP COMMD4 SF3A2 PSMB4 SEC13 RER1 NDUFS5 GANAB SDHA CS ESPL1 ANP32B C1QBP RUVBL2 PRMT1 DHCR7 NDUFAB1 MPV17 DDX49 GPI KXD1 ERP29 COX6B1 PUF60 POLR2I PRRC2C HSPA9 FUS SMARCD2 PSMD9 SOD1 TECR RAD23B PSMD8 PPP2R1A DDOST RBM14 CLTA TRAPPC3 SLC3A2 SF3A1 NDUFS3 KDELR1 PRPF31 SLC1A5 CLPP COX4I1 GNB2 UQCRFS1 CANX MTDH HUWE1 SMG7 UQCRC1 EIF3K RHEB COPS5 URM1 BZW1 EIF3I CTDNEP1 ALG8 EIF4E2 PSMB2 PSMB7 ACLY HNRNPA2B1 PARK7 XRCC6 SNRPD2 COX5B SET UQCRH down
## SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 0.0019763 0.0107056 -0.6738433 -3.168899 0 138 MRPL12 MYBL2 TIMELESS UBE2C STIP1 E2F1 SHMT2 PKMYT1 CCT5 RNASEH2A NUDT1 HJURP TACC3 AURKB MCM2 FEN1 CDCA8 BIRC5 NME1 ORMDL2 KIF18B MCM10 MCM4 TPX2 UBE2S FOXM1 PTTG1 CDC20 PLK1 MIS18A CCNB1 CEP55 SLC52A2 MKI67 KIF2C BYSL TROAP BUB1 QPRT TUBA1C KIF20A CDC25A RRM2 KIF15 NEK2 ESPL1 AURKA DDX39A ZWINT SNRPC NCAPG2 EXO1 LMNB1 TOP2A CENPF KIF4A KIF14 POLQ SLC7A5 MRPL15 MELK HMMR NCAPH PSMA7 NDC80 SPAG5 ASPM CENPA NUP93 MRPS17 DSN1 GTPBP4 CENPE EZH2 APOBEC3B TXN CCNA2 XPOT PRC1 DSCC1 GINS1 HMCES RFC4 SNRPF KIF11 CDKN3 MCM3 GTSE1 MAD2L1 DLGAP5 STMN1 CDK1 BUB1B CCNE2 TXNRD1 TIMM10 TTK NUSAP1 RACGAP1 MCM6 down
## GSE45837_WT_VS_GFI1_KO_PDC_DN 0.0019493 0.0107056 -0.6429835 -3.161092 0 180 BCS1L NPM3 MZT2A MRPS34 NDUFS6 MZT2B FASTK PSMD4 DAP3 LAMTOR2 SNRNP25 RFXANK PITPNM1 RBCK1 DECR2 TRADD CCT7 LMAN2 LSM7 HSPB1 SHMT2 EBNA1BP2 NIPSNAP1 CD2BP2 CLASRP AUP1 AAMP NUDT1 ETFB AHCY DNPH1 HEMK1 TOR3A ENSA PSMC5 DYNLRB1 UCKL1 ECI1 ARPC1B CLPTM1 C7orf26 NENF NME1 TCF20 HDHD3 DRAP1 EDF1 PLEKHJ1 EPS8L2 GRHPR CYB561D2 NTHL1 PSMB6 RANGRF MPG PSMD13 GANAB ZNF32 MRPS16 PRMT1 MRPL23 DDX49 PFKP ERP29 COX6B1 MPI COPS6 AEN POLR2I PIN1 CDC42SE1 VOPP1 POLR2F SNRNP35 DPM3 FUS PSMD9 SOD1 NUMA1 GNA12 PSMD8 MCM5 DALRD3 ZNF428 COG4 SAE1 MPDU1 RALGDS NDUFA7 ISG20 SNRPF PRPF31 ARF5 TBCA PDIA3 NDUFS7 SLC35C1 STOML2 EIF3K ECSIT ARL6IP4 EIF3I EEF2 CTDNEP1 DFFB UQCRQ SDHC HNRNPF BANP RPS7 XRCC6 SNRPD2 UQCR11 SET UQCRH YARS2 OCEL1 UBE2Z MRPL40 down
## ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 0.0019268 0.0107056 -0.6657973 -3.107423 0 130 DPP3 TK1 MAPK13 DTYMK MYBL2 UBE2C E2F1 LSM4 PAFAH1B3 TMSB10 HMGA1 HJURP ASF1B TACC3 AURKB MCM2 FEN1 SLC25A15 SAC3D1 CDCA8 BIRC5 CCNF MRPS15 KIF18B MCM10 MCM4 CHAF1B TPX2 UBE2S FOXM1 PTTG1 CDC20 PLK1 DNMT3B CCNB1 CEP55 MKI67 KIF2C LRP8 BUB1 CELSR3 KIF20A GINS4 RRM2 KIF15 NEK2 ESPL1 ATAD2 AURKA ZWINT LMNB1 TOP2A CENPM CENPF SMC4 KIF4A KIF14 POLQ CDC6 MELK ACACA HMMR NCAPH NDC80 SPAG5 ASPM DHFR CENPA CENPE EZH2 SHCBP1 HMGB2 APOBEC3B CCNA2 PRC1 GINS1 DNA2 KIF11 SPDL1 GTSE1 MAD2L1 DLGAP5 HELLS CDK1 BUB1B CCNE2 TTK PAQR4 BRCA1 NUSAP1 RACGAP1 GMNN KIF20B CDKN2A STIL down
## MODULE_54 0.0019608 0.0107056 -0.6007418 -3.095724 0 241 RECQL4 MAPK13 DTYMK MYBL2 TIMELESS RANBP1 WDR5 UBE2C RCC1 TUBA4A POLD1 UBE2T E2F1 NEIL3 PKMYT1 LMNB2 CCT5 ODC1 MCM7 NUDT1 HMGA1 HJURP CDK4 ASF1B AHCY TACC3 CDC25B AIMP2 CHAF1A AURKB MCM2 FEN1 CCT6A ZC3HC1 BIRC5 CDCA5 DDX11 CCNF SNRPE NME1 WIZ SRPK1 MCM4 NT5DC2 CHAF1B TPX2 UBE2S FOXM1 PTTG1 CDC20 NQO1 PLK1 CCNB1 CEP55 MKI67 KIF2C BYSL TROAP LRP8 BUB1 APEX2 LAPTM4B GGT1 PRDX4 RRM2 NEK2 ATAD2 AURKA ZWINT SNRPC OAS3 ORC1 LMNB1 TOP2A CDH1 ANLN CENPF SMC4 KIF14 POLQ CDC6 PFKP SLC7A5 KIAA0100 NUF2 MELK TNFRSF12A SCG5 HMMR PSPH RAD54L NCAPH PRR11 NDC80 SPAG5 PMAIP1 PLAT ASPM DHFR NCAPD2 CENPA CDC25C MCM5 CENPE SHCBP1 DLEU1 HMGB2 APOBEC3B CCNA2 CKAP2 GINS1 MUCL1 RFC4 RHNO1 SNRPF KIF11 GPN2 CDKN3 MCM3 SLC16A3 MAD2L1 IMPA2 ETV2 DLGAP5 HUWE1 CTPS1 KNTC1 ATF5 BEST3 FAM217B CDK1 BUB1B CCNE2 PIR TTK PLK4 PLP2 down
## chr19p13 0.0019881 0.0107056 -0.5591237 -3.092520 0 544 NACC1 ANO8 MRPL4 NCLN GTPBP3 NR2F6 HOOK2 MAST1 TRMT1 TMEM59L LONP1 CRLF1 QTRT1 AP3D1 RFXANK SMARCA4 KRI1 STAP2 NR2C2AP GCDH CAMSAP3 ATP13A1 RGL3 REEP6 FARSA TCF3 PPAN KISS1R THOP1 CC2D1A WDR18 SLC39A3 TYK2 JSRP1 CRTC1 STX10 LSM7 LSM4 YIPF2 GPX4 LMNB2 TMEM161A IL27RA RAVER1 ATG4D DENND1C TLE6 ABCA7 STXBP2 UHRF1 ZNF414 STK11 CRB3 RNASEH2A POLRMT DIRAS1 TUBB4A AP1M2 CSNK1G2-AS1 ARID3A SIRT6 ASF1B GADD45GIP1 RNF126 RPS18P13 RAB3D PRKCSH UPF1 CHAF1A C19orf57 MAP2K2 DPP9 CCDC124 P2RY11 DOHH SH2D3A TMPRSS9 C19orf25 TIMM44 NDUFA13 CALR CCL25 SUGP1 CACTIN DNMT1 KEAP1 CHERP PGLS APC2 VMAC BABAM1 DAZAP1 ARMC6 NDUFA11 HSH2D ELOF1 MPND GIPC1 HNRNPA1P10 AMH WIZ SLC25A23 HSD11B1L ILF3 MAP1S SCAMP4 BTBD2 PRDX2 LRRC8E PLEKHJ1 ADAT3 COPE SYCE2 PIAS4 EVI5L PCSK4 MEX3D FBXW9 EPHX3 RAD23A SPPL2B SPC24 CDC34 R3HDM4 ZNF653 SNORD105B GMIP APBA3 TMEM259 MED16 ZSWIM4 THEG HMG20B EPOR CCDC130 RN7SL619P AKAP8L GAMT SLC35E1 KHSRP HCN2 DDA1 CSNK1G2 CARM1 KCNN1 PCP2 POLR2E C19orf53 WDR83 DUS3L SF3A2 PTBP1 FEM1A LPAR2 XAB2 SAMD1 CCDC159 TIMM13 PET100 SGTA IL12RB1 NDUFB7 TNPO2 RAB11B MBD3 TNFSF9 EIF3G RN7SL477P MAP2K7 REXO1 RFX1 KLHL26 DCAF15 MVB12A KLF16 TMED1 PRR22 RN7SL192P ILVBL ZNF554 SIN3B PLK5 DDX39A CD320 GATAD2A RN7SL146P CELF5 MAU2 FCHO1 TPGS1 FSD1 ZGLP1 GTF2F1 JAK3 RAB3A RPL36 IZUMO4 DDX49 MIDN HMGB2P1 RNU6-1223P KXD1 DHPS BRD4 MLLT1 YJEFN3 ICAM3 SBNO2 PIN1 TSPAN16 MIER2 HNRNPM ZNF77 CDC37 OLFM2 PKN1 TLE2 USE1 GDF15 TECR ANKLE1 NANOS3 MPV17L2 KDM4B ABHD17A FUT3 RANBP3 MEF2B MOB3A CERS4 C3P1 BSG ANGPTL4 UBXN6 MKNK2 ZNF627 SSBP4 PGLYRP2 SLC25A42 TJP3 MRI1 ANGPTL6 INSL3 FGF22 CIRBP-AS1 NDUFA7 SAFB PLIN5 TGFBR3L EPS15L1 MAST3 TMEM205 MFSD12 SH3GL1 RASAL3 SUGP2 FKBP8 ZNF101 CLPP PDE4A PLIN4 SWSAP1 RNU6-9 RPS15 RLN3 NDUFS7 PGPEP1 CD70 LRG1 PLIN3 ECSIT FZR1 GPR108 ICAM1 ICAM5 down
## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0018832 0.0107056 -0.6743293 -3.076440 0 105 RHBDL1 RPUSD1 TELO2 MRPS34 CHTF18 NUBP2 TBL3 SNRNP25 CAPN15 MRPL28 MSRB1 AXIN1 RHOT2 KCTD5 NME4 ZNF598 RAB40C TSR3 FBXL16 DECR2 WDR90 NPRL3 ZNF213 PKMYT1 CLCN7 THOC6 EME2 POLR3K MSLNL UBE2I STUB1 ZNF205 PIGQ UNKL GFER WDR24 C16orf91 TRAF7 GNPTG NME3 WFIKKN1 JMJD8 TSC2 HAGH NTHL1 MPG METRN LMF1 CLDN6 PRSS27 RPS2 SPSB3 MSLN SRRM2 NDUFB10 GNG13 MAPK8IP3 TNFRSF12A SYNGR3 HAGHL KREMEN2 HCFC1R1 RHBDF1 MMP25 RAB11FIP3 RNF151 FAHD1 FLYWCH1 FLYWCH2 CLDN9 down
## MANALO_HYPOXIA_DN 0.0019724 0.0107056 -0.5914851 -3.074826 0 270 WDR4 BCS1L HMBS NCLN TELO2 PARP1 ABCF2 RRP1 LETM1 PFAS CIAO1 SLC25A10 FAM86C1 PWP2 UTP14A CAD RANBP1 RRP1B RPL39L SRRT URB1 NVL ATIC FAM136A RRS1 PKMYT1 PUS1 LMNB2 EBNA1BP2 ODC1 TUBG1 SRM TSFM NAT10 HMGA1 USP39 HJURP FASN ASF1B RRP9 SCLY POLR3K RUVBL1 AIMP2 CHAF1A SLC5A6 DDX23 TOR3A MCM2 FEN1 SLC25A15 EXOSC2 NOL12 ARMC6 METTL2B UMPS DDX11 CCNF POLD2 FANCG NME1 ILF3 NLE1 MRPS12 MCM10 GRWD1 MCM4 MAZ NOP56 TPX2 RBM28 UBE2S PCYT2 CLPB BYSL PRMT5 LRP8 GART AMDHD2 IPO4 POP7 PA2G4 GGT1 POLR2L PSME3 MRTO4 RSAD1 RRM2 NOLC1 C1QBP HNRNPU ZWINT URB2 PHB EXO1 DHCR7 PPIF POMT2 PAK1IP1 AKAP1 CDC6 TSR1 PRMT7 NUP85 MELK GEMIN2 PPAT DGCR11 DHFR FUS DDX19A PSMD11 NCAPD3 WDR74 GTPBP4 MCM5 SHCBP1 HEATR1 CCNA2 NUP188 TTLL4 RPP40 PRC1 CCNE1 GINS1 DNA2 BOP1 PAIP1 SPDL1 SLC1A5 C1orf112 WDR12 MCM3 MFN2 MAD2L1 CD3EAP TOP3A CTPS1 down
## WELCSH_BRCA1_TARGETS_DN 0.0019380 0.0107056 -0.6570725 -3.057768 0 127 EIF3B ALG3 PDCD11 SEC24C PWP2 GTF3C2 MGST1 AP3D1 CYC1 CAD UBAP2L RRP1B SMARCA4 PHKG2 CHD4 FARSA PMPCA RCC1 TRAP1 BMS1 ATIC POLD1 SSRP1 MOGS LMNB2 SRM EDC4 POLRMT NMT1 CDK4 FASN CDC25B AIMP2 CHAF1A SF3B2 HRAS MCM2 SOX4 DDX11 APEX1 MRPS12 NME3 SRPK1 BYSL HSP90B1 RASSF7 RPIA GALK1 HDLBP SNRNP70 CCND1 NOLC1 RAE1 FKBP4 AGPAT2 SCAP SLC7A5 RABEPK PPAT HK1 CDC37 MLEC PKN1 TAF1C POLG CLTA NUP188 CCNE1 SAFB BOP1 DANCR SLC1A5 CTPS1 TCOF1 SLC19A1 NUP214 KAT2A CKAP4 HSF1 SF3A3 GCSH BRD2 EMG1 RXRA PABPC4 down
## WONG_EMBRYONIC_STEM_CELL_CORE 0.0019763 0.0107056 -0.5780709 -3.045385 0 318 CRABP2 DPP3 MRPL4 MAPK13 PARP1 DTYMK DAP3 MRPL12 PPM1G MYBL2 FARSA NCL NME4 RCC1 STIP1 PDIA4 FAM136A EIF6 POLD1 NHP2 LSM4 PUS1 CCT5 EBNA1BP2 NIPSNAP1 CBX3 ECHS1 NDUFS2 MCM7 NOP2 UGDH CDK4 NUP107 POLR3K RUVBL1 TP53 CHAF1A KIF22 AURKB TIMM44 MRPS2 NLN MCM2 DNMT1 IPO9 PABPC1 CDCA8 PPP4C ENO1 NDUFA11 BIRC5 CDCA5 CCNF SNRPA APEX1 TRIP6 ACAD8 RNPS1 MCM4 NT5DC2 BANF1 EIF3A NONO MRPL11 CDC34 HNRNPAB CDC20 PLK1 HNRNPA1 NTHL1 BAX PSMB6 FBL GNL3 TGIF2 THOC3 BUB1 TIMM13 PSMB5 GART NDUFB7 POP7 PA2G4 KIF20A PSME3 MRTO4 RRM2 CCND1 NEK2 FDPS AURKA TEAD2 GLDC ORC1 PHB RUVBL2 EXO1 LMNB1 PRMT1 TOP2A NDUFAB1 SMC4 KIF4A NDUFB10 CDC6 RPS16 MRPL15 RCC2 ERP29 E2F3 GEMIN2 NCAPH PSMA7 NDC80 SPAG5 POLR2F NCAPD2 HSPA9 ZIC3 MRPS28 MRPS17 RAB34 NCBP2 RAD23B MCM5 HMGB2 CCNA2 RPP40 CKAP2 LSM10 RPL27A HNRNPL RPS27 TMEFF1 KIF11 CLPP CDKN3 MCM3 SERPINH1 GTSE1 MAD2L1 RPL13 DARS2 MRPL37 DLGAP5 HELLS COQ3 STOML2 EIF3K TCOF1 EIF3I CDK1 EEF2 BUB1B TIMM8B SDHC BRIX1 CTNNA1 TTK PLK4 EMC8 NUSAP1 RACGAP1 UQCR11 COX5B SET GNPDA1 SNRPD1 UQCRH CHEK2 RPS3 RPL10A PSMD14 down
## WHITEFORD_PEDIATRIC_CANCER_MARKERS 0.0018657 0.0107056 -0.6589485 -3.033271 0 108 RECQL4 TK1 SNRNP200 DTYMK RRP1 MYBL2 UBE2C UBE2T E2F1 LMNB2 ODC1 UHRF1 PAFAH1B3 RNASEH2A MCM7 NUDT1 CDK4 ASF1B PSAT1 DNMT1 PON3 MND1 SOX4 CDCA8 ENO1 BIRC5 CDCA5 NME1 ILF3 MCM4 ILF2 TPX2 PTTG1 CCNB1 MKI67 BUB1 MLLT11 CDC25A RRM2 NEK2 ESPL1 ATAD2 AURKA ZWINT TOP2A CENPF SMC4 KIF14 POLQ RCC2 NUF2 MELK NCAPH GAPDH DHFR CENPA MCM5 CENPE CCNA2 CKAP2 ZNF367 PRC1 CDCA2 RFC4 TMEFF1 KIF11 MFN2 MAD2L1 DLGAP5 STMN1 CDK1 TTK PLK4 down
## MORF_FBL 0.0019493 0.0107056 -0.6504998 -3.030358 0 129 EIF3B HDGF TBL3 PPM1G CYC1 CCT3 PDAP1 NCL NDUFV1 CCT7 LSM7 LSM4 JTB CBX3 RALY MCM7 NUDT1 HSP90AB1 TUFM AHCY UBE2I HSPD1 AURKB MRPL9 MCM2 CCT2 TMEM147 SNRPE SNRPA NME1 ILF3 EIF3C RNPS1 TRIM28 ILF2 BANF1 RAD23A NONO HNRNPAB HNRNPA1 HNRNPUL1 FBL FIBP SF3A2 IMPDH2 EIF3G CS ANP32B C1QBP RUVBL2 PRMT1 DDX49 GPI KXD1 PUF60 POLR2I FUS SOD1 PSMD8 PPP2R1A DDOST NDUFS3 UQCRFS1 RSL1D1 RPL14 EIF3K EIF3I PSMB2 PSMB7 HNRNPA2B1 PARK7 XRCC6 SNRPD2 SET UQCRH RPL10A down
## LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 0.0020000 0.0107056 -0.6035594 -3.023173 0 202 PYGO2 INPPL1 PC SLC4A2 CLPTM1L PMVK TDRKH DPP3 B4GALT3 MBD6 TMEM134 ABCF2 NDUFS6 FASTK TAF6 PDCD6 CCS HDGF CORO1B ADAR PRCC USP21 FADD PPP1R16A METTL1 EIF4G1 TSTA3 GCDH DENND4B POLR2H CCDC127 ALKBH4 PNN RMI2 CCT5 HAX1 JTB POLR2J CDK5 TSFM NDUFS2 YKT6 MCM7 NUDT1 NAT10 CDK4 PI4KB ZNF74 PMF1 KDM2A IGSF8 MED15 SLC12A7 DUSP12 PPP1CA MRPL9 CCT6A NKX2-1 DAP MAGEF1 CLCN2 ILF2 LY6E POLD4 SETDB1 RAD23A MRPL11 MRPL36 VEGFA DVL3 MAF1 PSMB4 LPCAT1 TUFT1 SDHA ZNF3 SSR2 ARHGEF11 AKT1 DHCR7 EGFR MRPL23 FIGNL1 CERS2 PARD3 MBIP COPS6 SLC39A1 PUF60 PIP5K1A SIVA1 GEMIN2 NUBP1 FAM131A SRD5A1 AGO2 PPP1R3D AIP DEDD NUMA1 TFDP1 MRPS17 P2RY6 MET FAM177A1 down
## SANSOM_APC_TARGETS_REQUIRE_MYC 0.0020080 0.0107056 -0.6008670 -3.022972 0 209 SMPD4 WDR4 SMYD5 TK1 TELO2 PPP1R14B GTPBP3 DTYMK POLR1A ZMYND19 QTRT1 METTL1 TIMELESS CAD MYBBP1A ANKRD39 PPAN THOP1 NELFA MRPL38 D2HGDH SAPCD2 CCT7 WDR34 ZNF213 NHP2 WDR62 SHMT2 LMNB2 KNOP1 NTMT1 SRM SRD5A3 DPH2 RNASEH2A MCM7 LHPP CDK4 RRP9 TP53 PTOV1 NFS1 GAS8 SLC35B2 SOX4 DRG2 ZNF444 SIGMAR1 LDB1 GIPC1 NME1 NBEAL2 GRWD1 NOP56 METTL2A USP20 SYTL1 RAD23A TRMT61A CCDC86 FHOD1 GAR1 POLE RANGRF FBL SMARCC1 ZSWIM3 TGIF2 DUS3L LRP8 MBD3 SLC29A2 MUS81 SHMT1 NOLC1 TXNRD2 ARX PMM1 POMT1 ZBTB48 DDX49 AAR2 RCC2 TNFRSF12A RAD54L SIVA1 HAGHL AAAS TMEM141 GEMIN5 RASSF4 ATG9B RPL31 CINP NFKB2 HES6 SNRPF HIRA RNASEH2C SETD4 CCT4 MCM3 SLC1A4 EXOSC1 GTSE1 NOL8 ALKBH2 ATRIP PDXK SFSWAP BUB1B KAT2A MVK EMC8 MAPK7 PCBP4 ADAT1 RNF157 down
## SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 0.0020161 0.0107056 0.5679581 3.008089 0 331 LDB2 PLSCR4 TACC1 PROS1 RECK SGCB ROR1 LMO2 EML1 COLEC12 ECM2 RGCC ZEB2 PLN OLFML1 PECAM1 TCF4 TMEM47 CD93 AKT3 RCBTB2 TGFBR2 DAB2 MME DCN FOXN3 SOBP ERG GRK5 TM6SF1 TLE4 JAM3 SPARCL1 PTEN HPGDS SPON1 ZEB1 KCTD12 QKI CPA3 FERMT2 FLI1 TRPC1 SGCD MSR1 OLR1 SSPN HEG1 TIMP3 PRNP SDC2 DNM3 PARVA ST3GAL6 ATP10D BICC1 CLEC7A NUAK1 PALLD MEIS2 SLC2A3 PDGFRA EMP1 CPQ MYL9 GIMAP6 SGK1 LOX ELK3 ACSL4 PKD2 LMCD1 SERPING1 COL14A1 ENTPD1 NBL1 MS4A4A HEY1 PTPRM LUM ALOX5 GPR65 P2RY14 WWTR1 LAMA4 HMOX1 TMEM204 DSE IGFBP7 CLEC2B CALD1 MMP1 GAS1 ASPN ZFPM2 CFH EFEMP2 FAS MNDA MEF2C ENPEP EVI2A KCNJ2 MXRA7 FSTL1 EDNRA IL1R1 NID1 RASSF2 CPVL CASP1 SPARC SRGN MMP2 PDLIM2 TUBB6 ETV1 LAMB1 SNAI2 SERPINF1 NDN FGL2 TYROBP THSD7A INHBA CDH11 PRRX1 HTRA1 DPYD TGFB1I1 DACT1 SKAP2 TFEC MRC2 AXL COPZ2 SLC7A7 ANGPTL2 F2R PDGFRB COL15A1 GPNMB IRAK3 GIMAP4 MAF CRISPLD2 SMAD7 MFAP5 RCAN2 EVI2B FBLN2 CTSK CTSS ANXA1 FBN1 ITGBL1 CCR1 LPXN NID2 MAP4K4 ARHGEF40 LDLRAD4 COL16A1 CCND2 RARRES2 ACKR3 GLIPR1 OLFML3 C3AR1 MMP11 LRRC17 TGM2 TRIM22 XYLT1 CELF2 EMP3 COL4A2 COL4A1 HSD17B6 PTPRC GFPT2 COL6A1 NOX4 CD53 COL6A2 up
## SABATES_COLORECTAL_ADENOMA_DN 0.0020619 0.0107056 0.5781630 3.004923 0 274 BTNL8 SEMA6D LYVE1 B3GALT5 OGN JAM2 BCHE GHR ABCG2 CD36 ADH1B ABI3BP SLC51B RUNDC3B COLEC12 MAMDC2 ASPA ABCA8 PDZD3 AOC3 TMEM100 FABP4 CDH19 MFAP4 TRPM6 FAM13C PRIMA1 MEIS1 SCN7A EFEMP1 NR5A2 FAM107A MEOX2 RBM24 PLP1 SYNPO2 LMOD1 GPM6B CLEC3B KCTD12 MT1M FBLN1 CA2 ATP1A2 WNT2B PDE6A CPNE8 RAB3B RERG TMOD2 PTPRR CTSG HOXD10 CHRDL1 UNC5C VIP MYLK RSPO2 SLC26A2 DPT CNN1 MYH11 GUCA2A BRINP3 SLC22A4 LIFR CA4 TMCC3 OSR1 C7 SFRP1 HSD17B2 ITIH5 MS4A8 CXCL12 TUSC3 COL14A1 ANGPTL1 ZNF536 GPX3 EDIL3 LRRK2 MEP1B EPB41L3 NAP1L3 SCARA5 CHP2 PCK1 BEND5 ZNF483 SV2B IGF1 PHLPP2 ZNF667-AS1 ADCY2 ASPN RSPO3 CFH RFX6 PCDH9 CNTN4 SETBP1 USP2 CYTL1 BEST4 TPH1 CDKN2B FXYD1 TNS1 BMP5 WASF3 CHGA FLRT2 THRB GLDN CPB1 CCL23 PLAC9 NRXN1 NLGN4X NDN NAALADL1 SLC4A4 EPHA7 HAPLN1 KCNIP4 TMEM200A CCDC80 EDN3 TRGC2 ENPP6 EPHA3 up
## LU_EZH2_TARGETS_UP 0.0019724 0.0107056 -0.5804929 -3.003387 0 257 TSPAN17 TLCD1 SHARPIN RPUSD1 PMVK PPP1R14B FOXK2 MFSD3 PUSL1 PSMD4 PGAP3 PODXL2 CBR1 LONP1 BCAS4 AP1S1 C8orf82 TYSND1 IRF7 RPS6KB2 PIH1D1 COMTD1 MTX1 OXLD1 MYL6B LMTK3 LSM7 ZNHIT1 RMND5B MIEN1 TRIB3 SIGIRR THOC6 NUDT1 ETFB CLDN7 RUVBL1 ISOC2 STUB1 KRTCAP2 FAM71E1 TOR3A ENSA F11R PDXP FGA WASH2P JOSD2 S100A2 NENF SNHG11 TRIM16L PEX16 TCF20 HSD11B1L TRIP6 NME3 PFKL PLEKHJ1 LAMTOR4 OGFR ELFN2 MEX3D BOK PSMC3 DLK2 CYB561D2 ISG15 ZDHHC16 RPAIN WDR83 SCAND1 MPG THOC3 ZCCHC3 AMDHD2 ZP3 LPCAT1 ATOX1 TUFT1 GANAB PRDX4 NOLC1 TRAPPC12 IFI35 KLHL35 ZMAT5 ZNF629 CSK UNC45A CPM RPL36 AHSA1 NCAPH2 ENDOG C1orf50 GALT NUDCD3 MAPKAPK3 RPS19BP1 HAGHL C1orf210 HCFC1R1 TMEM141 VOPP1 TESK1 DPM3 WDR45 WDR74 SNCG RHOF HES4 TRIM47 MGMT MKNK2 MAFA ODF2 SDC4 PAGR1 PCK2 CDK9 S100A13 APOBEC3F ALKBH2 RPL13AP6 S100A6 ACO2 DDIT3 ECHDC3 PSMB10 SDHC CCDC107 PSMB7 AKR1C2 RGS19 PITX1 SURF2 RPLP0P6 KLHDC9 CBY1 ZNF133 HBQ1 KLHDC3 OCEL1 SERF2 down
## MORF_BUB3 0.0019646 0.0107056 -0.5823501 -3.000894 0 243 SNRNP200 DAP3 SEC24C PPM1G TMED9 CYC1 CAD UBAP2L CCT3 NCL THOP1 NDUFV1 CCT7 LSM7 LSM4 SSRP1 LMNB2 CCT5 HAX1 AK2 SRM EDC4 CBX3 NDUFS2 MCM7 NUDT1 TUFM RNPEP AATF CHAF1A MAP2K2 RANGAP1 SF3B2 PDIA6 AURKB MRPL9 MCM2 FEN1 DNMT1 CHERP NUDC BRD8 CCT2 SNRPE SNRPA ILF3 PAICS TRIM28 IMPDH1 ILF2 UBE2S RAD23A NONO HNRNPAB HNRNPUL1 KHSRP FBL FIBP SF3A2 IMPDH2 BUB1 TXNL4A NDUFS5 GANAB SDHA CS ESPL1 ANP32B HNRNPU ZWINT CSK RUVBL2 DNAJC11 PRKDC DDX49 AHSA1 KXD1 ERP29 POLR2I SLBP HNRNPM HSPA9 FUS SOD1 TFDP1 NCBP2 PSMD8 MCM5 PPP2R1A DDOST TRAPPC3 NUP188 XPOT NDUFS3 ANP32A SAFB GOT2 RFC4 PRPF31 SLC1A5 CLPP MCM3 RSL1D1 MTDH UQCRC1 EIF3K RHEB COPS5 STMN1 EIF3I CTDNEP1 PSMB2 MRPS27 ACTL6A PSMB7 ACLY HNRNPA2B1 PARK7 XRCC6 SET MCM6 UQCRH down
## MORF_PHB 0.0019531 0.0107056 -0.6492842 -2.976916 0 113 B4GALT3 CSNK1D CAD MRPL28 TSTA3 TFAP4 PSD4 SRRT SPRN PSMD3 MTX1 WDR18 BMS1 NELFB EIF6 WDR62 CPSF4 PKMYT1 PSMD2 OTUB1 AATF ERAL1 PRKCSH RABGGTA SH2B1 ADAM15 DRG2 NUP62 DDX11 FANCG GRK6 PABPN1 IGSF9B ILF2 TOMM34 BAHD1 FDXR PCGF1 BPHL CNPPD1 HMG20B PSMB6 POLR2A CHD3 CS ILVBL TPR NFRKB PHB COPS6 BRD3 MCRS1 MEA1 MLEC TUBGCP2 NAP1L4 EML3 MPST CDC25C PCGF2 PARN NUP188 HNRNPL RPRD2 CCT4 CIB1 MFN2 XPO6 PLIN3 TCOF1 GNL2 SFSWAP down
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 0.0020040 0.0107056 0.6010322 2.975877 0 184 CAV1 PLSCR4 PROS1 SLIT2 RUNX1T1 CCDC50 BNIP2 REEP1 FBXL3 OLFML1 MYH10 TCF4 PMP22 DAB2 DCN EFEMP1 RBMS1 EXTL2 PSIP1 MAGI2-AS3 PTPN21 PTPN12 WNT2B MAP3K8 FRAS1 FERMT2 AP1S2 DOCK11 POLR2M KPNA5 FBXL7 RERG BNC2 GABPA RBFOX2 DDR2 TIMP3 EFHC1 PRNP SOCS5 ZYG11B UFSP2 SDC2 UBE2E2 CSGALNACT2 FER CRYBG3 C1orf198 RAB11FIP2 WDFY3 SOX6 HOXD8 MCOLN3 BLOC1S6 TGFB2 PKD2 SLC30A4 RNF146 TTC28 TAOK1 CFL2 LAMA4 DSE ATP2B1 ZNF483 CALD1 RGL1 KAT2B GAS1 ACSS3 FLNC ZFPM2 MNDA WASF3 GCA FAM13B SPRY1 RCHY1 CDON FAM153A FLRT2 CPVL ZKSCAN8 TMEM237 CBR4 BEX4 SIRPA OSTM1 NDN SBSPON CLIP4 CCDC80 HBB SPAG9 LXN NKX3-1 HTRA1 TCEAL1 PREPL SOD2 DPYD SPOCK2 GPNMB PROCR MAF TIAM1 WT1 CTSK TSPYL1 FBXO21 TMX4 TMEM45A ZBTB20 PTGS1 WNT5A CELF2 SRGAP2 ATP11C FZD7 CAP2 BTF3L4 GPRASP1 DOK5 NR2F1 KIF1B GPRASP2 up
## MORF_ANP32B 0.0019763 0.0107056 -0.6014110 -2.963532 0 183 EEF1D SNRNP200 HDGF CTBP1 PPM1G CYC1 CHD4 PDAP1 NCL NDUFV1 SART1 CCT7 LSM7 JTB CBX3 RALY MCM7 NUDT1 HSP90AB1 TUFM UBE2I SF3B2 PPP1CA HSPD1 AURKB MRPL9 PABPC1 CCT2 SNRPE SNRPA GNAS ILF3 EIF3C RNPS1 TRIM28 COPE BANF1 RAD23A NONO HNRNPAB HNRNPA1 HNRNPUL1 FBL COMMD4 SF3A2 PTBP1 PSMB4 EIF3G GANAB SDHA ANP32B SSR2 DDX49 NDUFA1 KXD1 ERP29 COX6B1 COPS6 PUF60 TAF7 RPL30 RPS24 FUS SMARCD2 SOD1 RPL36AL PSMD8 RPS6 PPP2R1A DDOST TATDN2 HMGB2 RPLP2 SF3A1 NDUFS3 COX4I1 GNB2 UQCRFS1 EIF3H RSL1D1 CANX MTDH RPL14 RPL7 EIF3K COPS5 URM1 EEF2 COX7C PSMB7 PARK7 XRCC6 SNRPD2 COX5B SET UQCRH down
## GNF2_CENPF 0.0019342 0.0107056 -0.7223847 -2.963439 0 58 DTYMK MYBL2 UBE2C MCM7 HJURP MCM2 FEN1 CDCA8 BIRC5 CCNF KIF18B MCM10 TPX2 UBE2S FOXM1 PTTG1 CDC20 MKI67 RRM2 KIF15 AURKA ZWINT TOP2A CENPF SMC4 KIF4A HMMR NDC80 ASPM CENPE SHCBP1 HMGB2 CCNA2 CKAP2 PRC1 RFC4 KIF11 MCM3 DLGAP5 CDK1 TTK PLK4 NUSAP1 down
## GNF2_CCNA2 0.0019380 0.0107056 -0.7084381 -2.956710 0 65 UBE2C MCM7 HJURP ASF1B AURKB MCM2 FEN1 CDCA8 BIRC5 KIF18B MCM4 TPX2 FOXM1 CDC20 PLK1 MKI67 KIF20A RRM2 ESPL1 AURKA ZWINT TOP2A CENPF SMC4 KIF4A KIF14 MELK HMMR NDC80 ASPM NCAPD2 CENPA CENPE EZH2 SHCBP1 HMGB2 CCNA2 PRC1 RFC4 KIF11 MCM3 DLGAP5 CDK1 BUB1B TTK NUSAP1 RACGAP1 MCM6 GMNN down
## MORF_RAN 0.0019646 0.0107056 -0.5754452 -2.956678 0 239 EEF1D SNRNP200 PDCD6 DAP3 HDGF CTBP1 PPM1G CYC1 CCT3 PDAP1 NCL NDUFV1 POLR2H MYL6B CCT7 HAX1 JTB NIPSNAP1 CBX3 RALY HSP90AB1 TUFM UBE2I DCTN2 PPP1CA HSPD1 MRPL9 PABPC1 CCT2 TMEM147 SNRPE SNRPA GNAS NME1 EIF3C MRPS12 RNPS1 TRIM28 RPS10 COX6C ILF2 COPE BANF1 RAD23A NONO HNRNPAB HNRNPUL1 PSMB6 FBL FIBP COMMD4 PTBP1 PSMB4 NDUFS5 RPN2 PPIA GANAB PSMB3 SDHA CS FDPS ANP32B SSR2 C1QBP RUVBL2 PRMT1 MRPL23 NDUFAB1 DDX49 GPI NDUFA1 KXD1 ERP29 COX6B1 COPS6 PUF60 RPL11 POLR2I RPL30 RPS24 FUS SMARCD2 SOD1 RPL36AL PSMD8 RPS6 PPP2R1A CLTA RPLP2 NDUFS3 HSPA8 COX4I1 UQCRFS1 EIF3H RPL13 CANX MTDH RPL14 HUWE1 STOML2 RPL7 EIF3K RHEB COPS5 EEF2 CTDNEP1 COX7C PSMB2 PSMB7 ACLY HNRNPA2B1 PARK7 XRCC6 SNRPD2 COX5B SET UQCRH down
## GSE24634_TREG_VS_TCONV_POST_DAY3_IL4_CONVERSION_UP 0.0019608 0.0107056 -0.5990967 -2.950450 0 182 DUS1L ISG20L2 MRPL24 DTYMK FBXO41 PWP2 LONP1 MYBL2 PFDN2 NUP210 NCL PMPCA NVL TSR3 NOC4L CDT1 ATIC IMP4 FAM136A CCT7 NPRL3 LSM4 ODC1 TARBP2 SRM ATP6V0E2 TSFM RNASEH2A HAUS5 NMT1 POLR3K RUVBL1 TACC3 CNPY2 HSPD1 EXOSC2 UBE2M CDCA8 ENO1 CCT2 POLD2 PABPN1 MRPS12 PRKD2 MCM10 ILF2 RBM28 LIG1 HNRNPAB PLK1 NTHL1 POLE MKI67 BYSL FIBP PRMT5 BZW2 PTBP1 SGTA WRAP73 POP7 RPUSD2 NOLC1 CS C1QBP DDX39A NCAPG2 EXO1 MRPL23 CENPF SLC7A5 NCAPH2 SUPT16H NUDCD3 MRPL17 AGO2 HNRNPM GAPDH PMAIP1 MAP4K1 CENPA NUP93 NCAPD3 CRCP CIAPIN1 FUT8 KIF18A DCLRE1A GINS1 SPDL1 CLPP CTPS1 TRAC KNTC1 COX17 EIF3I CTDNEP1 down
Clusters: 3 vs 1
fgsea_res <- fgsea_res_3v1
cond_nm <- 'Clusters: 3 vs 1'
fgsea_plot(fgsea_res$res_hm, pathways_title='Hallmark', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------------------------------------- ---------- ---------- ----------- ---------- ------------- ----- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## HALLMARK_MYC_TARGETS_V2 0.0015528 0.0045670 0.7104280 2.739480 0 57 TBRG4 MYBBP1A AIMP2 FARSA NOC4L SRM RRP9 SLC29A2 NOP2 PES1 EXOSC5 PPAN LAS1L IPO4 GRWD1 MRTO4 NOP56 CBX3 CDK4 IMP4 PUS1 RRP12 NOLC1 PPRC1 MCM4 DCTPP1 MPHOSPH10 PA2G4 PLK1 NIP7 HSPD1 PHB GNL3 TFB2M WDR74 BYSL TCOF1 SORD MAP3K6 up
## HALLMARK_MYC_TARGETS_V1 0.0014225 0.0045670 0.5787174 2.690424 0 189 EIF3B AIMP2 CSTF2 POLD2 TUFM HDGF SRM RNPS1 RRP9 PPM1G CYC1 CCT3 SRPK1 RANBP1 PSMD3 NHP2 LSM7 NOP56 CBX3 CCT5 PSMC4 CDK4 TXNL4A RUVBL2 SNRPA NOLC1 MRPL9 NDUFAB1 PPIA SF3B3 PRDX4 PSMA6 CCT7 TRIM28 MCM4 RPS2 MCM7 APEX1 CAD RSL1D1 PA2G4 GSPT1 MCM2 TFDP1 CCT2 ILF2 MRPL23 CTPS1 C1QBP PSMA7 HSPD1 PSMC6 HSP90AB1 RAD23B HNRNPA1 HNRNPU PSMB2 XPOT PHB NME1 RPS3 GNL3 PSMB3 FBL IMPDH2 RPS5 RPLP0 EIF3D SNRPD2 SSBP1 PABPC1 CLNS1A RPL22 FAM120A RPL18 GOT2 CDC20 SMARCC1 PABPC4 SRSF1 RPL14 KPNB1 HNRNPA2B1 SNRPD3 UBE2L3 GLO1 SF3A1 RPS10 XRCC6 SNRPD1 TARDBP PCNA PSMD8 CCT4 TYMS MCM5 RPS6 COX5A SNRPG VDAC1 NOP16 DUT DDX18 CANX RFC4 EEF1B2 PSMD1 RPL34 EIF2S2 CDC45 NCBP2 ACP1 up
## HALLMARK_GLYCOLYSIS 0.0014347 0.0045670 0.5777853 2.675639 0 188 HS6ST2 POLR3K NOL3 B3GALT6 RBCK1 CHPF2 B4GALT7 PC EGFR GUSB AGRN GALE IDUA TSTA3 ENO1 SLC25A10 GMPPA SDC1 LCT LHX9 MPI HAX1 ANKZF1 ALG1 PAXIP1 GPC4 BPNT1 HSPA5 PSMC4 MET EFNA3 CHST12 SRD5A3 PKM B3GAT3 XYLT2 PMM2 ALDOA QSOX1 GYS1 PGLS PPIA B3GAT1 ANGPTL4 HDLBP TPBG ADORA2B PYGB ELF3 B4GALT2 FKBP4 CHPF GFPT1 CTH VEGFA NDUFV3 TALDO1 CLN6 GALK1 COG2 SPAG4 CASP6 PPFIA4 PAM MED24 KIF20A CLDN9 GOT2 AURKA AKR1A1 PFKP DPYSL4 LHPP PHKA2 B3GNT3 GAL3ST1 ABCB6 SLC37A4 P4HA2 B4GALT1 TFF3 HMMR AGL ME1 COPB2 GOT1 SLC35A3 GMPPB SLC25A13 MIOX FAM162A PLOD1 CITED2 HOMER1 CHST2 FUT8 SDHC NT5E CYB5A ISG20 SOD1 NASP SLC16A3 ALDOB TXN SDC3 PRPS1 GPR87 IDH1 CENPA DDIT4 BIK up
## HALLMARK_DNA_REPAIR 0.0014815 0.0045670 0.5877804 2.626913 0 141 TAF6 NME3 POLR2J ITPA MPG APRT NME4 DGCR8 CANT1 NELFCD ADRM1 NT5C FEN1 POLR2H POLL ALYREF GUK1 GPX4 EDF1 UMPS SUPT5H POLR1C SNAPC4 TP53 GTF2F1 SSRP1 NELFB POLD1 ERCC2 CMPK2 POLR2E AAAS SNAPC5 TARBP2 UPF3B ZWINT TAF12 POLR2F CCNO NME1 TAF1C VPS37B POLR2A IMPDH2 SEC61A1 POLD4 GTF3C5 GMPR2 SAC3D1 DGUOK SF3A3 ERCC3 LIG1 POLR2D COX17 POLE4 RPA3 TAF10 GTF2A2 POLH POLD3 POLR2I ADCY6 NFX1 ERCC1 DDB1 POLA2 VPS28 PCNA POLR1D TYMS ELL RAE1 up
## HALLMARK_E2F_TARGETS 0.0014265 0.0045670 0.5595137 2.602594 0 191 TBRG4 WDR90 POLD2 AK2 PMS2 UBE2T HMGA1 TK1 TUBG1 TIMELESS RANBP1 KIF22 PNN POP7 NOP56 CDK4 TP53 SSRP1 NUP205 POLD1 DNMT1 NOLC1 PPP1R8 CIT CHEK2 ATAD2 MYBL2 ILF3 PRDX4 POLE MCM4 ASF1B MCM7 TACC3 DCTPP1 PRKDC PA2G4 NUP107 GSPT1 MCM2 CDCA8 CTPS1 PLK1 PAICS UBE2S SLBP RAD50 RNASEH2A SHMT1 NME1 BIRC5 SNRPB RRM2 CDKN2A KIF4A LIG1 CDC25B MKI67 MXD3 TIPIN POLE4 DDX39A CDC20 PAN2 PHF5A RPA3 CENPM HUS1 AURKA KIF2C MCM3 PTTG1 KIF18B DSCC1 POLD3 SRSF1 AURKB SPC24 XRCC6 ESPL1 GINS4 BUB1B EZH2 NCAPD2 BRCA1 MELK POLA2 PCNA LMNB1 HMMR CTCF CDC25A MCM5 LYAR NAA38 CENPE RPA1 CHEK1 SMC4 NASP DUT DLGAP5 CKS2 PRPS1 CCNE1 GINS1 up
## HALLMARK_OXIDATIVE_PHOSPHORYLATION 0.0014368 0.0045670 0.5482188 2.527058 0 175 AIFM1 ECI1 NDUFS6 NDUFS8 MRPS15 RHOT2 NDUFV1 CYC1 ATP1B1 PDP1 MFN2 TIMM50 ACADVL ECHS1 NDUFB2 NDUFB7 GPX4 PMPCA ETFB MRPL11 NDUFS2 NDUFAB1 SDHA TIMM13 IDH3B HSPA9 BAX NDUFA1 NDUFS3 POLR2F MRPS12 OGDH PDHA1 MTRR COX6B1 UQCRQ NDUFS7 CS IDH2 SLC25A5 COX4I1 TIMM8B TCIRG1 ACO2 ETFA OAT TOMM22 ACADSB MRPL34 ECH1 ACAA1 COX17 GRPEL1 COX6C TIMM9 MRPS11 GOT2 TIMM10 SDHB NDUFC1 COX7C RETSAT UQCRH GPI SLC25A11 OXA1L NDUFB1 COX5B UQCR10 MTX2 UQCR11 TIMM17A FH MRPL15 UQCRC1 LRPPRC FXN NDUFA4 SUCLG1 SLC25A4 IMMT UQCRC2 NDUFA2 AFG3L2 COX8A COX10 COX5A SDHC CYB5A VDAC1 NQO2 BCKDHA ATP6V0E1 LDHB DLST IDH1 up
## HALLMARK_UNFOLDED_PROTEIN_RESPONSE 0.0014881 0.0045670 0.5464398 2.346018 0 103 EDC4 RRP9 NOP14 EXOSC5 LSM4 EIF4G1 NHP2 GEMIN4 NOP56 HSPA5 ARFGAP1 PSAT1 ASNS KHSRP NOLC1 SLC7A5 ALDH18A1 PARN EXOSC10 HSPA9 CXXC1 PREB EXOSC2 BANF1 IFIT1 TUBB2A PAIP1 VEGFA ZBTB17 IMP3 NFYA XPOT YIF1A SRPRB ERN1 DCTN1 FUS PDIA6 SHC1 CALR BAG3 EXOSC1 EEF2 EIF4EBP1 RPS14 CHAC1 ATP6V0D1 SLC1A4 CEBPB CNOT2 FKBP14 ATF4 SERP1 XBP1 SDAD1 DDIT4 SLC30A5 PDIA5 HSP90B1 up
## HALLMARK_G2M_CHECKPOINT 0.0014535 0.0045670 0.5046336 2.329949 0 187 E2F4 EGF CCND1 HMGA1 PRMT5 NUMA1 KIF22 UBE2C NCL CHAF1A TNPO2 CDK4 E2F1 CCNF CHMP1A NOLC1 HOXC10 DTYMK LIG3 SLC7A5 MYBL2 ILF3 UPF1 POLE TLE3 TACC3 EFNA5 GSPT1 MCM2 MNAT1 TFDP1 PLK1 RAD23B INCENP UBE2S HNRNPU TOP1 E2F2 BIRC5 CBX1 BCL3 HIRA KIF4A CDC25B MKI67 TRAIP SLC12A2 PML ODF2 STIL DDX39A CDC20 TPX2 RAD54L HUS1 AURKA KIF2C SMARCC1 SMAD3 MCM3 PTTG1 SRSF1 AURKB KPNB1 NEK2 BUB1 TROAP CDC6 ESPL1 EXO1 SLC7A1 SNRPD1 EZH2 CENPF POLA2 HSPA8 LMNB1 HMMR CTCF RBM14 CDC25A MCM5 ARID4A CENPE ORC5 CHEK1 SMC4 NASP KIF23 POLQ E2F3 CKS2 NDC80 CENPA ORC6 TOP2A CDC45 PRC1 DBF4 NUSAP1 KIF15 up
## HALLMARK_MTORC1_SIGNALING 0.0014184 0.0045670 0.4817965 2.242469 0 190 TRIB3 TM7SF2 ABCF2 DHCR7 FKBP2 CCT6A RRP9 TUBG1 STIP1 ENO1 SQSTM1 PDAP1 FDXR PSPH SDF2L1 YKT6 TUBA4A HMBS HSPA5 PSAT1 PSMC4 CCNF NMT1 NUP205 TOMM40 ASNS ALDOA SHMT2 SLC7A5 PPIA PFKL PSMB5 MCM4 SC5D ACACA DDIT3 MCM2 HSPA9 PLK1 NFKBIB CTH HSPD1 PSMC6 PSME3 ARPC5L PSMD13 RRM2 SLC1A5 CYP51A1 CYB5B PSMC2 CALR SERPINH1 SRD5A1 GAPDH DDX39A AURKA GPI SORD ACLY BUB1 HSPA4 PPA1 SLC37A4 SLC9A3R1 UCHL5 SLC1A4 DHFR RPN1 IMMT DHCR24 PHGDH ATP2A2 ME1 GOT1 CDC25A CACYBP ELOVL6 GSR PSMA3 RPA1 MAP2K3 CANX SERP1 TCEA1 LGMN XBP1 GMPS MLLT11 IDH1 up
## HALLMARK_ESTROGEN_RESPONSE_EARLY 0.0014265 0.0045670 0.4448204 2.069095 0 191 MYBBP1A TFF1 SYT12 ISG20L2 DHCR7 LAD1 CCND1 CANT1 AKAP1 NADSYN1 P2RY2 TBC1D30 ESRP2 WWC1 CLDN7 MLPH TFAP2C RHOD SFN CALCR NAV2 RRP12 MUC1 SLC7A5 NCOR2 SLC37A1 TPBG AQP3 SCNN1A NXT1 RAB17 KRT18 GREB1 ANXA9 ELF3 FKBP4 AREG FRK KCNK15 TJP3 OVOL2 KCNK5 DHRS3 RPS6KA2 KRT8 MREG ADCY1 PTGES TSKU TUBB2B BLVRB PMAIP1 CELSR1 MYOF TTC39A ASB13 MED24 SLC22A5 RHOBTB3 ADCY9 CISH ENDOD1 CELSR2 KDM4B FASN ABAT KRT19 B4GALT1 UNC119 SLC9A3R1 FDFT1 FHL2 SLC1A4 TFF3 KLK10 DEPTOR RASGRP1 LRIG1 TIPARP PPIF up
## HALLMARK_INTERFERON_ALPHA_RESPONSE 0.0015221 0.0045670 0.4735384 1.996922 0 93 ISG15 HELZ2 LGALS3BP LY6E ADAR USP18 PSME2 RNF31 MX1 MVB12A PARP14 IRF7 IFI35 CMTR1 CMPK2 OGFR RSAD2 HERC6 BST2 PARP9 TRAFD1 STAT2 OAS1 MOV10 PNPT1 TRIM5 BATF2 TRIM14 IFI44L PSME1 TRIM21 NUB1 IFIT3 IFIH1 IFI27 PARP12 UBE2L6 IL4R GMPR IFI44 CASP8 PSMA3 NCOA7 ISG20 OASL IFITM1 UBA7 IFIT2 SP110 IFITM3 CSF1 up
## HALLMARK_UV_RESPONSE_UP 0.0014663 0.0045670 0.4390661 1.976792 0 147 MAPK8IP2 SPR EPCAM ONECUT1 CDC34 MARK2 STIP1 SQSTM1 PDAP1 CLCN2 FEN1 POLR2H YKT6 TUBA4A STK25 SIGMAR1 ASNS BSG WIZ ALDOA PSMC3 E2F5 AQP3 FKBP4 MRPL23 BAK1 HNRNPU NPTXR TCHH COL2A1 CYB5R1 CYB5B GLS PARP2 CLTB KCNH2 ACAA1 GRPEL1 PPAT AGO2 RAB27A TST BTG3 ICAM1 TGFBRAP1 LHX2 CHRNA5 CHKA CDC5L RPN1 CTSV SLC25A4 IGFBP2 FURIN RASGRP1 PPIF UROD STARD3 TYRO3 DGAT1 RFC4 CCNE1 up
## HALLMARK_ESTROGEN_RESPONSE_LATE 0.0014327 0.0045670 0.4057739 1.884574 0 193 MAPK13 PKP3 TFF1 MDK ST14 DHCR7 GALE LSR CCND1 TSTA3 TFPI2 DLG5 TFAP2C DCXR SFN ETFB CALCR SLC7A5 NCOR2 CDH1 SLC2A8 TPBG SCNN1A LLGL2 NXT1 ANXA9 METTL3 FKBP4 PRLR NAB2 AREG GPER1 FRK TJP3 PCP4 OVOL2 KCNK5 RPS6KA2 BATF PTGES RNASEH2A UGDH IDH2 BLVRB MYOF SLC22A5 COX6C KIF20A ASS1 ASCL1 STIL AGR2 CDC20 TST CISH BTG3 CELSR2 SCUBE2 SORD NMU CDC6 IMPA2 PLXNB1 KRT19 SLC9A3R1 FDFT1 SLC1A4 IGSF1 TFF3 KLK10 DNAJC1 UNC13B PPIF ALDH3A2 DNAJC12 SIAH2 XRCC3 ISG20 up
## HALLMARK_MITOTIC_SPINDLE 0.0014286 0.0045670 0.3786124 1.760660 0 195 CEP72 CTTN ARHGEF11 RHOT2 NUMA1 KIF22 TUBA4A ARHGAP27 EPB41 GEMIN4 CEP250 TUBGCP6 MAP1S BCR NET1 KPTN CSNK1D BIN1 ARL8A PCNT ARFIP2 MARK4 CDC42EP1 PLK1 TAOK2 INCENP CYTH2 DYNLL2 SHROOM1 MAP3K11 ARF6 BIRC5 ATG4B CNTROB STAU1 KIF4A SAC3D1 OPHN1 MID1IP1 CDC42BPA LLGL1 TPX2 FGD6 AURKA TRIO KIF2C KATNB1 TUBGCP2 CKAP5 ANLN NEK2 BUB1 EZR CLIP1 ESPL1 ARHGDIA KIF1B TBCD LRPPRC CENPF ABR PIF1 DYNC1H1 LMNB1 RHOF SHROOM2 CENPE TUBGCP5 ARHGEF2 ACTN4 SMC4 KIF23 PLEKHG2 DLGAP5 WASL NDC80 KIF3B CD2AP BCAR1 RANBP9 KIF3C MYH9 TOP2A PRC1 NUSAP1 KIF15 KNTC1 up
## HALLMARK_ADIPOGENESIS 0.0014430 0.0045670 0.3695237 1.707006 0 183 ESRRA REEP6 ABCB8 AIFM1 AK2 DHCR7 CYC1 CHCHD10 SLC25A10 ECHS1 NDUFB7 GPX4 RREB1 ETFB NMT1 ALDOA NDUFAB1 BAZ2A PFKL ANGPTL4 ELMOD3 YWHAG PREB NDUFS3 DHRS7 PIM3 ARAF LIPE SLC5A6 CRAT AGPAT3 FAH UQCRQ TALDO1 CS COQ9 PEX14 SLC27A1 SLC1A5 CD151 ACO2 GADD45A ORM1 BCL6 RAB34 ECH1 GRPEL1 SDHB APLP2 TST RETSAT HADH ACLY ATL2 UQCR10 MGLL RMDN3 UQCR11 UCP2 DDT UCK1 VEGFB UBC ADCY6 MRPL15 UQCRC1 ACADS SUCLG1 PTCD3 IMMT PFKFB3 MCCC1 COX8A ME1 BCL2L13 up
## HALLMARK_P53_PATHWAY 0.0014184 0.0045670 0.3622519 1.686062 0 190 RAB40C PVT1 TRIB3 ST14 WRAP73 HRAS SDC1 FDXR DCXR TRAF4 PHLDA3 EPS8L2 TP53 SFN HDAC3 LIF VAMP8 RPL36 FGF13 DDIT3 PLXNB2 STEAP3 BAK1 MKNK2 ABHD4 MAPKAPK3 BAX CSRNP2 AEN TRAFD1 TM7SF3 TCHH IER5 GLS2 VDR UPP1 GADD45A SEC61A1 CDKN2A EPHA2 RPL18 SLC3A2 TNFSF9 RETSAT EI24 RPS12 RNF19B ZFP36L1 POLH RAD9A BAIAP2 HINT1 PRKAB1 ABAT MDM2 TNNI1 PMM1 CCNK RHBDF2 SAT1 PCNA RALGDS OSGIN1 HEXIM1 FAM162A SERPINB5 up
## HALLMARK_INTERFERON_GAMMA_RESPONSE 0.0014327 0.0045670 0.3403283 1.580290 0 194 ISG15 RBCK1 HELZ2 LGALS3BP LY6E ADAR USP18 MVP PSME2 PLA2G4A MX2 AUTS2 RNF31 OAS3 MX1 PARP14 IRF7 IFI35 RNF213 CMTR1 CMPK2 ST3GAL5 OGFR SECTM1 METTL7B RSAD2 HERC6 VAMP8 BST2 IFIT1 PSMB2 TRAFD1 PSMB10 STAT2 NUP93 PNPT1 UPP1 IFNAR2 BATF2 TOR1B PML XAF1 NOD1 TRIM14 ICAM1 PFKP IFI44L PSME1 ISOC1 TRIM21 OAS2 IFIT3 ZNFX1 ZBP1 BPGM IFIH1 PELI1 IFI27 PARP12 UBE2L6 LYSMD2 IL4R IFI44 CASP8 CD38 PTGS2 NLRC5 PSMA3 up
## HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 0.0033445 0.0070146 -0.3560320 -1.820630 0 189 ABI3BP DAB2 GLIPR1 SLIT3 SGCG SLIT2 NTM TGFBR3 ID2 PCOLCE2 VIM SGCB ECM2 IL15 PTX3 SFRP1 DCN FBLN5 FGF2 CXCL12 PMP22 SGCD TIMP3 LAMA2 DST CDH6 BDNF LUM VEGFC LOX MYLK POSTN TNFRSF11B MYL9 FBN2 FBLN1 EDIL3 SNAI2 CD59 MGP FERMT2 ITGA5 BMP1 SERPINE2 FAS IL6 NNMT THBS1 TGM2 EMP3 MATN2 FOXC2 ACTA2 CALD1 FSTL1 OXTR ITGB1 DKK1 TPM1 CXCL6 PDGFRB PRSS2 PRRX1 VCAM1 FAP SERPINE1 WIPF1 JUN TAGLN MFAP5 LRP1 CAP2 TPM4 down
## HALLMARK_PEROXISOME 0.0029762 0.0070146 0.4171468 1.790927 1 103 ABCB9 MVP CTBP1 HRAS CRABP2 ACOT8 FDPS SLC35B2 FIS1 PRDX5 PEX6 CTPS1 GSTK1 DHRS3 HSD3B7 CRAT CLN6 IDH2 PEX14 CEL PABPC1 PEX13 ERCC3 ECH1 ACAA1 ACSL5 RETSAT GNPAT SMARCC1 MLYCD ISOC1 ERCC1 HMGCL SLC25A4 DHCR24 CRABP1 SLC25A17 LONP2 NUDT19 PEX5 up
## HALLMARK_INFLAMMATORY_RESPONSE 0.0032895 0.0070146 -0.3459434 -1.780578 0 193 CALCRL SELE CYBB LPAR1 OLR1 VIP CCRL2 TACR1 MSR1 CMKLR1 SLC31A2 IL18R1 IL15 TLR1 PTGER4 CD69 GPR183 ATP2B1 RNF144B CD48 NMUR1 C3AR1 CSF3R MARCO IL1B C5AR1 ABI1 FPR1 GPC3 P2RX7 IL7R CSF3 BEST1 EDN1 RGS1 LCP2 PDE4B APLNR PTAFR LAMP3 KLF6 IL18RAP AQP9 IL1A ITGA5 PIK3R5 IL6 LTA NLRP3 SELL PROK2 ABCA1 CCR7 ACVR2A EMP3 SLC1A2 PTGIR down
## HALLMARK_CHOLESTEROL_HOMEOSTASIS 0.0031201 0.0070146 0.4478333 1.770076 1 69 PMVK TRIB3 TM7SF2 GUSB DHCR7 PCYT2 FDPS TNFRSF12A CTNNB1 FBXO6 SC5D ACSS2 CBS ABCA2 MVD MAL2 ERRFI1 CYP51A1 ECH1 HSD17B7 ALDOC GLDC FASN S100A11 MVK CHKA FDFT1 up
## HALLMARK_KRAS_SIGNALING_UP 0.0033670 0.0070146 -0.3450113 -1.767940 0 190 IL33 PECAM1 TLR8 LCP1 ID2 SPARCL1 PRKG2 CMKLR1 HSD11B1 ETS1 EPB41L3 GYPC ACE CLEC4A IRF8 FLT4 KLF4 TSPAN7 C3AR1 ABCB1 SPON1 RELN PDCD1LG2 RBP4 IL1B ENG CDADC1 GNG11 F13A1 ARG1 LAPTM5 NR1H4 USP12 RBM4 IL7R MTMR10 LY96 EMP1 RETN PEG3 CD37 FCER1G EVI5 PTBP2 CBL CTSS CAB39L CXCR4 CCND2 ADAM17 DOCK2 down
## HALLMARK_ALLOGRAFT_REJECTION 0.0031847 0.0070146 -0.3432413 -1.765921 0 187 GPR65 KLRD1 SRGN IFNGR1 FGR LY86 PF4 ETS1 PTPRC IL15 TLR1 IRF8 CCL4 IL16 JAK2 IGSF6 IL1B CFP CD40LG CD86 ABI1 CRTAM PRKCB CD8A LCP2 CCR1 CD96 IL2 CD28 CCR2 SOCS5 CCL19 TRAT1 IL18RAP CTSS CD8B UBE2N CCND2 CD3G F2R GZMA ELANE MBL2 FAS IL6 NLRP3 TLR6 CD4 ACVR2A NCK1 ITGAL CCR5 C2 CD80 FCGR2B CCL2 PRF1 STAT4 MAP3K7 LY75 NOS2 ITK HLA-DMA TGFB2 GZMB HCLS1 IL18 B2M CD1D CXCL13 CD3E APBB1 GBP2 RIPK2 IL10 SIT1 IFNG F2 FASLG IL2RG CD2 down
## HALLMARK_COMPLEMENT 0.0032895 0.0070146 -0.2955083 -1.520988 0 193 CD36 GNB4 C9 LIPA OLR1 CR1 CDH13 ZEB1 GNG2 ACTN2 DGKH GZMK PLEK PRCP DOCK4 SH2B3 JAK2 LTF ANXA5 CD40LG PLG CASP3 FCN1 PIK3CA CASP5 IRF2 CASP1 DOCK10 LCP2 SPOCK2 FCER1G S100A12 SERPINB2 CALM1 C1QA DGKG KYNU CTSS GNAI2 PDGFB CLU CPQ CD59 SERPING1 GZMA ITGAM PLA2G7 CR2 PIK3R5 IL6 SCG3 down
## HALLMARK_FATTY_ACID_METABOLISM 0.0058651 0.0117302 0.3406494 1.533694 3 147 REEP6 ECI1 BLVRA GCDH NTHL1 ACOT8 D2HGDH ACADVL ECHS1 NCAPH2 PCBD1 AQP7 ALDOA BPHL SDHA APEX1 IDH3B ENO3 CPOX ALAD CBR3 CRAT PDHA1 UGDH GRHPR ACO2 CEL ECH1 ACAA1 SLC22A5 CBR1 ACSL5 RETSAT HSD17B7 HADH ERP29 PSME1 MGLL MLYCD FASN CCDC58 PRDX6 FH HMGCL ACADS SUCLG1 UROS DHCR24 UBE2L6 ME1 G0S2 CPT2 ALDH3A2 SDHC GSTZ1 PPARA UROD ADSL DLST IDH1 up
## HALLMARK_PI3K_AKT_MTOR_SIGNALING 0.0074405 0.0143086 0.3797367 1.630315 4 103 TRIB3 EGFR HRAS RPTOR SQSTM1 TSC2 TRAF2 FGF6 CDK4 E2F1 SFN ARF1 AKT1 GNA14 ACACA DDIT3 NFKBIB MKNK2 PPP1CA PAK4 STAT2 RPS6KA1 PIN1 AKT1S1 PITX2 ECSIT CALR NOD1 GNGT1 PLCG1 TNFRSF1A RAC1 ARHGDIA THEM4 CFL1 up
## HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 0.0125000 0.0231481 0.4332997 1.589328 7 46 GPX4 STK25 PRDX2 NDUFS2 ERCC2 PRDX4 HMOX2 NQO1 MGST1 SBNO2 SCAF4 ABCC1 TXNRD2 PFKP PRDX6 GSR ATOX1 SOD1 TXN SRXN1 up
## HALLMARK_HEME_METABOLISM 0.0129870 0.0231911 0.3012183 1.388769 8 179 PIGQ EIF2AK1 PC SPTB HDGF BLVRA HAGH MOCOS CROCCP2 MKRN1 MFHAS1 HMBS EPB41 FBXO34 RAD23A PRDX2 LRP10 ASNS BSG PGLS OSBP2 AQP3 TSPAN5 CPOX ALAD TOP1 RNF123 E2F2 BLVRB DMTN KHNYN DCAF11 NARF ADIPOR1 LPIN2 FN3K ENDOD1 GDE1 CTNS SLC30A10 RNF19A FTCD CDR2 ABCB6 PPP2R5B P4HA2 UCP2 NFE2L1 IGSF3 ATP6V0A1 BPGM SLC6A9 UROS RAP1GAP ATG4A HTATIP2 CAST SELENBP1 PDZK1IP1 MAP2K3 PSMD9 UROD RHCE TCEA1 PPOX GMPS up
fgsea_plot(fgsea_res$res_c1, pathways_title='C1 positional genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------- ---------- ---------- ----------- ---------- ------------- ----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## chr16p13 0.0013587 0.0113397 0.6434804 3.116362 0 272 SNRNP25 MLST8 DNAJA3 MRPS34 TBL3 GLYR1 TELO2 RPUSD1 RHBDL1 C16orf91 WDR24 POLR3K UBN1 NMRAL1 AXIN1 PIGQ JMJD8 TRAF7 UBE2I METRN THOC6 PGP NME3 WDR90 SMIM22 ZNF598 RAB40C NUBP2 ECI1 CAPN15 WFIKKN1 KCTD5 ZNF500 TSR3 E4F1 CHTF18 NUDT16L1 TFAP4 RHOT2 MPG GFER EME2 SLX4 NME4 ANKS3 RNPS1 ZNF205 DNASE1 ZNF213 NTHL1 CLDN6 PRSS22 NTN3 ROGDI NPRL3 TRAP1 CLCN7 DECR2 SRRM2 HAGH SNORD60 PKMYT1 ZNF174 NOMO1 MGRN1 MRPL28 TSC2 PRSS27 ZSCAN32 STUB1 GNPTG RHBDF1 RMI2 ALG1 NDUFB10 PAQR4 KREMEN2 PPL TNFRSF12A LMF1 FBXL16 UBALD1 TPSP2 MSRB1 WASH4P RAB11FIP3 CCNF CCDC154 TBC1D24 DNASE1L2 FLYWCH2 FAHD1 CLEC16A BRICD5 ZNF263 PMM2 HAGHL HMOX2 TMEM186 SNHG9 CARHSP1 RPS2 PDXDC1 AMDHD2 TXNDC11 RSL1D1 PARN METTL22 GSPT1 DDX11L10 HCFC1R1 MAPK8IP3 PDPK1 PRSS33 UNKL MIR5587 WASIR2 MIR3176 ABCC6 NUBP1 PRSS41 TIGD7 ABCC6P2 ABCC1 NAGPA CREBBP IL9RP3 GNG13 CLDN9 ADCY9 ZC3H7A IFT140 RRN3 TEKT5 BAIAP3 CASKIN1 SPSB3 COX6CP1 SYNGR3 ABCA17P PAM16 IMPDH1P11 NOMO3 BFAR ABAT MIR3177 up
## chr19p13 0.0012407 0.0113397 0.5730473 2.967658 0 544 HOOK2 STAP2 GTPBP3 NACC1 FARSA ANO8 SMARCA4 MRPL4 GIPC1 REEP6 AP3D1 CAMSAP3 NR2F6 SH2D3A QTRT1 TRMT1 NR2C2AP LONP1 TMEM161A CC2D1A NCLN SCAMP4 RFXANK WDR18 GCDH POLRMT CDC34 BTBD2 MAST1 GDF15 STX10 TIMM44 EVI5L STK11 TMEM59L PPAN AP1M2 LSM4 YIPF2 FEM1A PCSK4 DOHH THOP1 CRB3 SLC39A3 GADD45GIP1 LRG1 CCDC124 ATG4D MPND C19orf57 P2RY11 RGL3 NDUFB7 KRI1 GPX4 LSM7 SF3A2 AMH CELF5 TCF3 SLC35E1 ILVBL SLC25A23 LMNB2 DHPS RAD23A CHAF1A MVB12A PRKCSH DUS3L TNPO2 CCDC159 PRDX2 HMG20B RNF126 PTBP1 ATP13A1 MED16 CCDC130 DPP9 RAB11B MAP1S LRRC8E ELOF1 PLEKHJ1 R3HDM4 GTF2F1 CDC37 REXO1 TLE6 STXBP2 XAB2 KXD1 DNMT1 MLLT1 KLF16 CHERP KHSRP BSG ARMC6 WIZ MEX3D CACTIN MIDN MAP2K2 TMEM259 DDA1 HSH2D EIF3G DAZAP1 PGLS SNORD105B SGTA ILF3 FZR1 POLR2E UPF1 JSRP1 ODF3L2 RAVER1 SIRT6 ANGPTL4 FUT3 PIAS4 ADAT3 ABCA7 MAP2K7 CD320 TECR C19orf53 ASF1B CRLF1 TIMM13 UCA1 SPPL2B RPL36 ZNF414 SAMD1 ADAMTSL5 TYK2 C19orf25 BABAM1 KEAP1 ZSWIM4 PRR22 BST2 MIR3189 GPR108 CARM1 FBXW9 TICAM1 TJP3 MKNK2 GAMT HSD11B1L TPGS1 CSNK1G2 MPV17L2 PCP2 SBNO2 FBXL12 TUBB4A WDR83 RN7SL192P MIER2 GATAD2A CRTC1 DDX49 UHRF1 EPS15L1 KLHL26 TMED1 AKAP8L IL27RA RNASEH2A PGPEP1 C19orf44 NDUFA13 NDUFS7 NDUFA11 PET100 UBXN6 PIN1 TGFBR3L HNRNPA1P10 DCAF15 RFX1 SLC27A1 ONECUT3 INSL3 SIN3B PDE4A EPHX3 VMAC BRD4 USE1 ICAM5 COPE RPS15 RAB11B-AS1 TLE2 TMEM205 APBA3 CIRBP-AS1 MRPL34 ARID3A ALKBH7 PLK5 ECSIT CALR MFSD12 C19orf71 SUGP2 RAB3A RPL18A ANKRD24 RPS28 NFIC LPAR2 TNFSF9 DDX39A PALM3 ZNF77 RAB3D EEF2 FKBP8 MBD3 ICAM1 RN7SL619P ZNF554 HAUS8 CLPP PLIN3 CERS4 ZNF653 SH3GL1 C19orf67 RNU6-9 KDM4B ELAVL1 MAU2 EFNA2 MED26 SSBP4 ZFR2 DOT1L SPC24 B3GNT3 RPS18P13 UQCR11 GNA15 HNRNPM APC2 SUGP1 AKAP8 THEG OCEL1 KISS1R ZBTB7A RN7SL146P ZNF317 MADCAM1 SWSAP1 PKN1 EEF1DP1 MRPL54 PLIN5 SNAPC2 ABHD17A OLFM2 FCHO1 IZUMO4 DIRAS1 SAFB CSNK1G2-AS1 RFX2 ZNF121 RANBP3 ARHGEF18 MISP DAPK3 GNA11 up
## chr11q13 0.0013550 0.0113397 0.5995921 2.925879 0 290 RCE1 INPPL1 DPP3 FADD FAM86C1 MACROD1 SNORD15B ESRRA TRPT1 TMEM134 NUDT22 OTUB1 SPTBN2 CTTN PPP1R14B NDUFS8 NUDT8 PC KLHL35 SYT12 TM7SF2 DHCR7 FLRT1 FKBP2 NDUFV1 SLC29A2 COA4 CCND1 MARK2 SYVN1 MEN1 CCS NAA40 SSH3 STIP1 CAPN1 CDK2AP2 STARD10 CLPB NADSYN1 CORO1B NUMA1 PLCB3 DGAT2 P2RY2 GPR137 BRMS1 PITPNM1 SART1 CCDC87 RPS6KA4 RNF121 SCYL1 C2CD3 OVOL1 RPS6KB2 BAD PPME1 RHOD ZNHIT2 DNAJC4 FIBP KLC2 MRPL11 SF3B2 MRPL21 MRPL49 TRMT112 PGM2L1 DOC2GP CDC42BPG LAMTOR1 FAM86C2P CST6 PRDX5 CATSPER1 IGHMBP2 PPFIA1 EIF1AD LTBP3 KDM2A ALG1L9P SLC25A45 PAAF1 VPS51 HNRNPA1P40 RELA CLCF1 OR7E126P LRP5 DRAP1 SHANK2 ATG2A BANF1 RCOR2 MALAT1 PPP1CA CARNS1 MRPL48 LRFN4 MUS81 MAP3K11 YIF1A ALDH3B2 RPS3 ZDHHC24 TSKU FAM89B CDCA5 ANKRD13D TCIRG1 OR7E128P POLD4 GDPD5 SAC3D1 C11orf24 ACY3 FRMD8 DPF2 BATF2 MIR3163 PELI3 SERPINH1 EHBP1L1 FAU LIPT2 AP001372.2 CNIH2 XRRA1 GSTP1 MYO7A TIGD3 RAD9A POLD3 P2RY6 AP5B1 SF1 C11orf80 RIN1 RAB1B PPP2R5B RNF169 UCP2 NEAT1 UCP3 CHKA PACS1 VEGFB CFL1 KRTAP5-8 AIP CCDC88B POLA2 up
## chr12q21 0.0027397 0.0113397 -0.6702340 -2.900396 0 66 TRHDE-AS1 TRHDE PTPRQ GLIPR1 LIN7A CSRP2 ZDHHC17 OSBPL8 ATP2B1 CHCHD3P2 NTS TMTC3 DCN PPP1R12A NAV3 METTL25 BBS10 LUM GLIPR1L1 LRRIQ1 NAP1L1 RASSF9 TSPAN19 RNA5SP363 GLIPR1L2 PPFIA2 MIR618 BTG1 KRR1 CAPS2 ACSS3 SLC6A15 RNU6-977P MIR1252 KERA MGAT4C RNA5SP364 YWHAQP7 down
## chr1q22 0.0015723 0.0113397 0.7645142 2.898678 0 53 RAB25 SMG5 RHBG C1orf61 DAP3 UBQLN4 SLC50A1 MTX1 GON4L SCARNA4 CCT3 LAMTOR2 FDPS KRTCAP2 ASH1L-AS1 GBAP1 RUSC1 MUC1 MSTO2P MEX3A IQGAP3 TMEM79 DPM3 EFNA1 YY1AP1 GBA TSACC THBS3 POU5F1P4 PAQR6 RUSC1-AS1 SSR2 MEF2D MIR92B TRIM46 MSTO1 ASH1L LMNA PMF1 up
## chr7p22 0.0015337 0.0113397 0.6825086 2.830936 0 85 PSMG3 EIF3B C7orf50 AIMP2 FBXL18 INTS1 ZDHHC4 BRAT1 IQCE TNRC18 EIF2AK1 PMS2 MIR589 GET4 MAD1L1 FAM220A MAFK TMEM184A ZNF12 PMS2CL C7orf26 FOXK1 ZNF316 GRID2IP WIPI2 RNF216P1 AP5Z1 USP42 ZNF890P SNX8 CHST12 SUN1 DAGLB COX19 ADAP1 NUDT1 MICALL2 TTYH3 GPER1 PSMG3-AS1 ANKRD61 RNF216 CARD11 C1GALT1 KDELR2 RBAK GNA12 PRKAR1B SLC29A4 ALG1L5P RAC1 MIR339 SDK1 RNU6-218P CCZ1 CYTH3 up
## chr1p36 0.0013038 0.0113397 0.5518472 2.768953 0 395 SSU72 MST1P2 ARHGEF19 DVL1 NADK NOC2L SMIM1 RER1 PUSL1 ISG15 ATAD3A PLEKHN1 MST1L AURKAIP1 ATAD3B B3GALT6 DHDDS PAX7 CEP85 PEX10 MRPL20 FBXO2 FBXO44 TMCO4 ZBTB48 ATAD3C LRRC47 LYPLA2 CNKSR1 RNF207 NUDC AGRN TMEM222 WRAP73 UBE2J2 GALE C1orf174 SRM ARHGEF16 ENO1 ACAP3 C1orf159 MIR34A DNAJC11 MTOR MFN2 MIIP CCNL2 NPHP4 CROCCP2 RERE SDF4 TP73-AS1 VWA1 CEP104 MRTO4 SPEN ATP13A2 TCEA3 MTATP6P1 CALML6 GPN2 MTND2P28 TMEM201 CDK11B MIB2 KIAA2013 SFN SCNN1D CLCNKA HES4 GRHL3 TAS1R3 DNAJC16 FBXO6 KLHL17 RCC2 SLC35E2B TNFRSF25 ARID1A PANK4 SNORA59A EIF4G3 KLHDC7A TNFRSF18 PARK7 OTUD3 MAD2L2 PLA2G2C TMEM52 ARHGEF10L EXOSC10 MTND1P23 PHF13 SYTL1 RPL11 DFFA LINC00339 RNU5E-1 UBR4 DDOST TMEM88B RNF223 NBPF3 DHRS3 EMC1 CROCCP5 ZDHHC18 LINC00337 ZBTB17 MORN1 PRKCZ AKR7A3 LDLRAP1 SRRM1 E2F2 AUNIP MTHFR RPS6KA1 PEX14 ERRFI1 CICP27 UBE4B ESPNP WDTC1 SZRD1 CDK11A THAP3 CASP9 AKR7A2 MIR4689 AGMAT MUL1 UBIAD1 FBXO42 CCDC27 RN7SL574P CROCCP4 SLC45A1 CTNNBIP1 PGAM1P11 EPHA2 RPL22 CLCNKB AGTRAP IFFO2 ANKRD65 SDHB ALPL GPR157 VPS13D GPATCH3 DFFB MIR429 TMEM51-AS1 H6PD ICMT NOL9 MIR200B MEGF6 CICP3 NIPAL3 EPHB2 CASZ1 NCMAP IFNLR1 DRAXIN MAP3K6 PRDM16 EXTL1 KIF1B ALDH4A1 CROCCP3 PDIK1L OSTCP2 MMP23A SLC25A33 TARDBP RN7SKP269 HMGCL ESPN MTFR1L FAM131C PAFAH2 ACOT7 LINC00115 MIR200A RAP1GAP DDI2 CLSTN1 PLCH2 PRDM2 RNU6ATAC18P ZBTB40 CLCN6 WASH7P PIGV PLOD1 SLC9A1 TMEM51 NPPA PLA2G2F NR0B2 HES5 PADI1 TNFRSF14 AKR7L ASAP3 RHCE EPHA8 NMNAT1 ECE1 TMEM240 up
## chr7q22 0.0014684 0.0113397 0.6081429 2.761056 0 153 TAF6 PPP1R35 ACHE UFSP1 POLR2J BAIAP2L1 AP1S1 ZNHIT1 CUX1 SLC12A9 TRIP6 TFR2 TRIM56 PDAP1 ALKBH4 LRCH4 SMURF1 GIGYF1 SRRT ZNF3 AP4M1 MOSPD3 SPDYE6 SPDYE2 ARPC1A LRWD1 POP7 ZSCAN25 TSC22D4 CPSF4 MIR4653 PUS7 PLOD3 LAMTOR4 FIS1 SPDYE3 GNB2 TRRAP COPS6 MCM7 ARPC1B KPNA7 MIR25 MUC3A PILRB DNAJC2 POLR2J3 PMS2P1 ZKSCAN5 EPHB4 AGFG2 GPC2 TRIM4 FBXO24 MBLAC1 ORAI2 STAG3L5P VGF SLC26A4 ZSCAN21 MEPCE PSMC2 PTCD1 NAT16 BUD31 NAPEPLD ACTL6B AZGP1 SLC26A5 RN7SL549P KMT2E-AS1 ZNF394 FAM200A RWDD4P1 ARMC10 SPDYE2B GJC3 RN7SL750P up
## chr16p11 0.0015361 0.0113397 0.6162808 2.690525 0 120 ASPHD1 RNF40 KCTD13 PHKG2 FBXL19 CD2BP2 ZNF629 RABEP2 SRCAP MVP EIF3C ZNF764 SH2B1 ZNF646 TUFM C16orf58 TBC1D10B FBRS ATXN2L ZNF48 QPRT SETD1A ZNF768 SEZ6L2 KAT8 KIF22 PAGR1 NFATC2IP TBX6 PRSS8 ZNF785 PRR14 PPP4C ALDOA FBXL19-AS1 ZNF771 DCTPP1 HIRIP3 BCKDK MAZ CDC37P1 TMEM219 SLC7A5P1 TAOK2 ZNF688 YPEL3 HSD3B7 SEPHS2 SULT1A2 CTF1 HERC2P4 FUS INO80E STX4 ZNF668 VKORC1 ZNF689 ARMC5 CLUHP3 CDIPT GDPD3 ATP2A1 BCL7C up
## chr17q25 0.0014205 0.0113397 0.5645602 2.650250 0 202 CBX4 DUS1L OGFOD3 CCDC137 LGALS3BP SLC38A10 LRRC45 NPLOC4 NAT9 EVPL P4HB CBX8 PYCR1 CHMP6 UBE2O OXLD1 CANT1 TSEN54 RPTOR ANAPC11 TK1 SLC25A10 MRPL12 FOXK2 NT5C ARL16 FDXR FN3KRP GPS1 RAC3 RECQL5 ALYREF PCYT2 HGS GGA3 TMC6 DCXR RFNG B3GNTL1 PPP1R27 RNF213 HID1 ASPSCR1 CCDC57 SECTM1 FADS6 SYNGR2 SIRT7 CSNK1D FSCN2 FBF1 MRPS7 RPL38 ENDOV LLGL2 ARMC7 TMEM104 RPL9P29 EXOC7 COG1 ENGASE SRP68 TBC1D16 SLC39A11 LINC00482 SAP30BP TRIM65 BIRC5 GALK1 MRPL38 NUP85 WDR45B KCTD2 GPRC5C CDR2L NARF RAB40B TRIM47 TSPAN10 SLC16A5 FN3K MYADML2 SNHG16 BAHCC1 UBALD2 MIF4GD BAIAP2 FASN ZNF750 SGSH ARHGDIA TNRC6C-AS1 RHBDF2 SLC9A3R1 CDK3 TBCD WBP2 up
## chr7q36 0.0015267 0.0113397 0.6064419 2.588460 0 101 SLC4A2 FASTK TMUB1 ZNF282 REPIN1 ABCB8 CHPF2 ZNF786 ZNF212 MNX1-AS1 CDK5 ABCF2 PDIA4 ZNF398 MNX1 ATP6V0E2 NOM1 ACTR3B ZNF777 SHH ZBED6CL LRRC61 PAXIP1 UBE3C MNX1-AS2 ZNF746 PAXIP1-AS1 SSPO ZNF783 EN2 ZNF467 AGAP3 GALNT11 RNY1 ZNF425 KRBA1 LINC01003 XRCC2 ESYT2 KMT2C ASIC3 ZNF862 WDR60 CRYGN NCAPG2 KCNH2 ATG9B ZNF775 WDR86 MIR3907 RBM33 ACTR3C RHEB NUB1 RN7SL521P SMARCD3 EZH2 up
## MT 0.0016667 0.0113397 0.7545495 2.556744 0 31 MT-CO2 MT-CYB MT-TN MT-ND4L MT-TH MT-ND3 MT-ND2 MT-TC MT-TP MT-ATP6 MT-CO3 MT-ND4 MT-RNR2 MT-ATP8 MT-ND5 MT-RNR1 MT-ND1 MT-ND6 MT-TV MT-TS2 MT-TM MT-CO1 MT-TF MT-TL2 up
## chr7p13 0.0016556 0.0113397 0.7329422 2.540967 0 35 TBRG4 NUDCD3 DDX56 TMED4 NPC1L1 SNORA5C POLM POLD2 URGCP SNORA5A BLVRA DBNL ZMIZ2 YKT6 SNHG15 RASA4CP PPIA CCM2 OGDH COA1 UBE2D4 SPDYE1 TUBG1P LINC00957 POLR2J4 up
## chr3p14 0.0028818 0.0113397 -0.5607650 -2.538232 0 83 DNASE1L3 KBTBD8 RBM43P1 EOGT FAM107A PXK ASB14 DENND6A DNAH12 SNTN RNU6-1181P RNF7P1 LMOD3 APPL1 NDUFB4P1 IL17RD ABHD6 C3orf49 ARL6IP5 PRICKLE2-AS2 PTPRG-AS1 ADAMTS9-AS1 PRDX3P4 RNU6-787P ADAMTS9 PRICKLE2-AS3 PRICKLE2 RPL17P17 ILF2P1 ADAMTS9-AS2 PDHB MAGI1-IT1 PSMD6 RNU2-10P MAGI1-AS1 down
## chr9q34 0.0014144 0.0113397 0.5341653 2.520811 0 210 NOXA1 RNF208 PPP1R26 MRPS2 ZMYND19 SAPCD2 NSMF PAEP TPRN RABL6 DOLPP1 ARRDC1 TRUB2 QSOX2 PTGES2 WDR34 ZDHHC12 EDF1 ASB6 GOLGA2 LCN12 TRAF2 PMPCA SNAPC4 FPGS MAN1B1 NDOR1 PHPT1 MIR4479 AGPAT2 C9orf163 SEC16A NELFB WDR5 MRPL41 DDX31 PIP5KL1 NTMT1 SNHG7 DPH7 SSNA1 C9orf16 FCN2 SH3GLB2 DPP7 TOR2A MAMDC4 ABCA2 SLC27A4 TMEM203 DPM2 FBXW5 ANAPC2 TOR4A EXOSC2 SLC34A3 CIZ1 C8G PPP1R26-AS1 RNF224 PTGES CRAT GLE1 LCN2 ENTPD8 COQ4 TUBBP5 ENDOG NAIF1 STXBP1 CEL TMEM141 NCLP1 GTF3C5 TMSB4XP4 PRRC2B BRD3 EHMT1 SWI5 ZER1 ABO SURF2 PRDM12 TOR1B ST6GALNAC4 ASS1 ODF2 GRIN1 SURF4 NUP188 up
## chr13q33 0.0025126 0.0113397 -0.6526245 -2.471400 0 35 RPL39P29 FGF14-AS1 MYO16 FGF14-AS2 LIPT1P1 FGF14-IT1 LINC00551 MIR4705 SLC10A2 RNY1P2 FGF14 LINC00399 TNFSF13B ABHD13 BIVM RNA5SP39 down
## chr3p24 0.0027473 0.0113397 -0.5962009 -2.465038 0 54 ZNF385D ZNF385D-AS1 NEK10 RBMS3-AS3 ZNF385D-AS2 RNU6-342P UBE2E2 EFHB NKIRAS1 RBMS3-AS2 FAM96AP1 KAT2B PP2D1 RBMS3 RPL31P20 ZCWPW2 UBE2E1 PLCL2-AS1 RBMS3-AS1 PLCL2 TBC1D5 AZI2 EOMES CMC1 RARB RAB5A TGFBR2 MIR3135A HMGB1P5 down
## chr16q22 0.0014881 0.0113397 0.5454740 2.435466 0 132 HSF4 NOL3 ELMO3 EDC4 TRADD FBXL8 E2F4 PDF SLC9A5 NOB1 PARD6A ACD COG4 PRMT7 ESRP2 FTLP14 TMEM208 EXOSC6 FHOD1 MARVELD3 NUTF2 VPS4A PSKH1 SF3B3 DDX19A CDH1 CES3 CDH3 NQO1 CA7 DDX19B NIP7 CENPT KIAA0895L WWP2 SLC7A6 SLC7A6OS PSMB10 VAC14 DHX38 PDP2 ENKD1 DUS2 HAS3 CYB5B DYNC1LI2 CES2 TANGO6 RN7SL279P DHODH CMTM4 DDX28 ZDHHC1 C16orf70 THAP11 TERF2 COG8 up
## chr1q21 0.0014184 0.0113397 0.5196914 2.426111 0 191 ZBTB7B FLAD1 EFNA4 PYGO2 CGN UBAP2L TARS2 DCST2 ADAR PMVK ZNF687 PSMD4 ADAM15 UBE2Q1 JTB VPS72 HAX1 SCNM1 ENSA TDRKH SPRR1B DCST1 PI4KB DENND4B EFNA3 SETDB1 ACP6 IVL RORC CRTC2 MRPL9 CERS2 PBXIP1 C2CD4D SPRR2D PIP5K1A ANXA9 PSMB4 RNVU1-7 ILF2 C1orf43 HORMAD1 RFX5 OAZ3 RPRD2 TUFT1 TCHH LYSMD1 UBE2Q1-AS1 GATAD2B SLC39A1 CREB3L4 C1orf56 THEM5 RPS27 IL6R SHC1 S100A14 S100A13 MRPS21 TPM3 S100A1 POGZ SPRR3 PFN1P6 LINC00624 SNX27 CA14 CDC42SE1 S100A11 NUP210L TDRD10 SNAPIN MIR4258 NBPF20 MIR5698 THEM4 S100A5 MIR4257 GOLPH3L CHTOP up
## chr8q24 0.0014327 0.0113397 0.5147688 2.391626 0 185 RHPN1 ZNF623 TOP1MT MROH6 EEF1D SHARPIN OPLAH ZFP41 TONSL RHPN1-AS1 LY6E ZNF696 PVT1 RECQL4 PPP1R16A MFSD3 LRRC14 MROH1 THEM6 TIGD5 TSTA3 ZC3H3 CYC1 TSNARE1 TRAPPC9 GSDMD CYHR1 TRMT12 GPT KIFC2 KCNQ3 SLC45A4 ATAD2 C8orf82 GLI4 PTP4A3 SNTB1 TMEM75 MIR1207 RPL8 GSDMC WDYHV1 MAL2 FAM83A SAMD12 NDUFB9 MIR1205 ZNF517 FOXH1 ZNF7 COMMD5 MAF1 SLC39A4 RNU11-4P AGO2 PCAT1 TMEM65 C8orf31 ZNF16 COL22A1 SLC52A2 ARHGAP39 PTK2 DSCC1 C8orf33 ADCK5 BOP1 PUF60 CDC42P3 MAFA FER1L6-AS1 RNU1-106P VPS28 EIF3H ZNF252P RNU4-25P ZHX2 TRIB1 MIR151A DEPTOR CPSF1 up
## chr13q13 0.0024691 0.0113397 -0.5866501 -2.361807 0 46 ATP8A2P2 STARD13-AS PDS5B STARD13-IT1 N4BP2L1 STARD13 KL RXFP2 STOML3 DCLK1 RFXAP TRPC4 SERTM1 RNY1P4 N4BP2L2 POSTN CSNK1A1L NHLRC3 FRY down
## chr20q13 0.0013569 0.0113397 0.4794035 2.317621 0 265 SAMD10 PRPF6 DNTTIP1 MTG2 HELZ2 TNNC2 ZNF512B WFDC3 RBBP8NL YTHDF1 DIDO1 PABPC1L ABHD16B MRGBP CABLES2 SLC2A4RG GID8 MIR941-2 TAF4 NELFCD OSBPL2 ADRM1 ZGPAT SNX21 ACOT8 DNAJC5 UBE2C LSM14B PPDPF WFDC10B UCKL1 ZSWIM3 TFAP2C DDX27 RPS4XP3 ARFGAP1 EEF1A2 SLC35C2 TCFL5 ZSWIM1 GNAS WFDC2 ARFRP1 OGFR MYBL2 ZFP64 BCAS4 GMEB2 RPS21 PTK6 SS18L1 PIGT MIR647 NCOA5 MIR941-1 SDC4 TPD52L2 KCNK15 PSMA7 LIME1 TTPAL ATP9A HNRNPA1P3 MIR941-3 WFDC13 NTSR1 TOMM34 RTEL1 ZMYND8 SPATA2 ZNF217 CDH4 STAU1 MATN4 CTSA COL9A3 FITM2 PPP1R3D ZNF335 TMEM189 L3MBTL1 NPEPL1 PMEPA1 AURKA PI3 RNU6ATAC38P RPL12P4 MIR3617 ZFAS1 MYT1 RNU1-134P ARFGEF2 PCIF1 PFDN4 MIR646 B4GALT5 ZNFX1 ZBP1 SPINT5P LINC01056 SALL4 CSTF1 GNAS-AS1 SPINT4 TP53RK STX16 RAE1 DBNDD2 ERP29P1 TSHZ2 CEBPB LAMA5 ELMO2 RGS19 RNF114 RPL5P2 OGFR-AS1 MIR4326 up
## chr3q13 0.0027933 0.0113397 -0.4771868 -2.292400 0 121 TUSC7 RPS26P21 LINC00901 RNU6-1127P ARHGAP31-AS1 LSAMP-AS1 LINC00903 RNU6-1200P RN7SL582P RNU4-62P YBX1P3 CD200 FCF1P3 RNU5E-8P LSAMP FBXO40 MAATS1 MIR568 MIR4447 RN7SL172P PTMAP8 ZBTB20-AS3 MTND4P16 ZBTB20-AS4 B4GALT4-AS1 LINC00882 CD86 RNU1-43P CD96 ARHGAP31 ZBTB20-AS2 CD200R1 PHLDB2 TRAT1 MTND5P16 BTLA MTND1P16 EAF2 OR7E100P LINC00636 ZBED2 CCDC54 CCDC80 ADPRH FSTL1 ZBTB20-AS1 CD80 down
## chr1p31 0.0028490 0.0113397 -0.4795614 -2.291434 0 120 PTGFR TCTEX1D1 TTLL7 DNASE2B TTLL7-IT1 LRRC53 AK5 ST6GALNAC3 DNAJB4 NEXN RNA5SP23 PRKACB GDI2P2 GIPC2 LRRC7 ATG4C ZRANB2-AS1 L1TD1 CFL1P3 NEGR1 RNFT1P2 RNU4-88P ST13P20 RNU6-1102P ANGPTL3 ROR1 NEXN-AS1 USP33 SGIP1 PSAT1P3 PDE4B MIR3671 SLC2A3P2 WDR78 ZRANB2-AS2 MED28P8 LEPROT MIR3117 MIR101-1 DOCK7 MIER1 PIGK ACADM PTGER3 TNNI3K RNU6-809P TM2D1 RNA5SP22 JAK1 HNRNPA3P14 RNU7-80P NFIA MIR186 IL23R TYW3 RNA5SP20 FPGT-TNNI3K C1orf141 FUBP1 RN7SL370P FPGT LRRIQ3 down
## chr1p35 0.0015361 0.0113397 0.5351562 2.273036 0 99 SNORA73B AK2 IFI6 MECR RCC1 KIAA1522 SNHG12 SNHG3 TMEM54 TXLNA XKR8 EPB41 SESN2 OPRD1 BSDC1 PPP1R8 EIF3I PTPRU PHACTR4 HPCA SMPDL3B SRSF4 AHDC1 TAF12 MED18 TRNAU1AP SNORD99 TRIM62 SCARNA1 TMEM234 YTHDF2 ZNF362 SNRNP40 ZSCAN20 MARCKSL1 SNORA44 MATN1-AS1 SERINC2 RNF19B PRDX3P2 IQCC KPNA6 PEF1 HDAC1 PUM1 FNDC5 ZBTB8OS PHC2 ZCCHC17 SDC3 KHDRBS1 TMEM39B SPOCD1 up
## chr1q42 0.0015267 0.0113397 0.5182187 2.259171 0 119 MRPL55 C1orf35 PYCR2 TRIM11 JMJD4 PARP1 PSEN2 SNORA14B MAP10 SNAP47 TMEM63A RNF187 TRIM17 GUK1 NVL B3GALNT2 ARF1 TARBP1 TBCE LINC00184 SLC35F3 TRIM67 COA6 ACBD3 URB2 BTNL10 EXOC8 GALNT2 COG2 IRF2BP2 FTH1P2 KCNK1 C1orf131 DNAH14 TAF5L CDC42BPA CNIH4 MIR4427 ARID4B TTC13 GNPAT TOMM20 RNU6-968P GGPS1 OBSCN SPRTN NUP133 FBXO28 ARV1 ABCB10 SNAP47-AS1 FAM96AP2 GNG4 RNU6-1008P SIPA1L2 PGBD5 C1orf198 MIR5008 CICP5 NTPCR RAB4A LIN9 RNY4P16 RAC1P7 ENAH RPS7P3 up
## chr6q21 0.0028490 0.0113397 -0.5105537 -2.243468 0 71 SESN1 TRAF3IP2-AS1 ARMC2-AS1 ZNF259P1 CEP57L1 LINC00222 FIG4 REV3L-IT1 REV3L BVES SNX3 ARMC2 SUMO2P8 CDC40 DDO RNU6-960P METTL24 BRD7P4 RPS24P12 AK9 BVES-AS1 RNU6-527P OSTM1 FOXO3 PPIL6 FCF1P10 LAMA4 RPL23AP50 QRSL1 RNU6-653P SEC63 SLC22A16 POPDC3 FCF1P5 FYN RNU6-437P CD164 SCML4 down
## chr16q24 0.0015267 0.0113397 0.5311750 2.236173 0 92 VPS9D1-AS1 DBNDD1 CDH15 APRT SLC22A31 VPS9D1 GAS8 CTU2 SPATA2L CDT1 GSE1 SPG7 CHMP1A ZNF778 SLC7A5 CENPBD1 SPATA33 ACSF3 URAHP ZC3H18 MVD CDK10 RPL13 SPIRE2 KLHDC4 MTHFSD TUBB8P7 CPNE7 FAM157C DEF8 EMC8 ZNF276 TAF1C COX4I1 FANCA ANKRD11 GALNS TCF25 AFG3L1P ATP2C2 KLHL36 TRAPPC2L CYBA ZFPM1 AC010536.1 MBTPS1 JPH3 PIEZO1 HSDL1 USP10 ZDHHC7 MC1R IL17C ZCCHC14 up
## chr22q13 0.0014245 0.0113397 0.4720251 2.229131 0 215 MAPK8IP2 CRELD2 GCAT PDXP PICK1 PACSIN2 C22orf46 TCF20 ARSA RANGAP1 L3MBTL2 TTC38 ELFN2 WNT7B ADM2 TRABD TTLL12 NCAPH2 TUBGCP6 SBF1 RPS19BP1 CPT1B CBY1 UPK3A TRMU SCO2 ZC3H7B ZBED4 CHKB LMF2 MCAT PPP6R2 PANX2 CHADL APOBEC3B DESI1 PLXNB2 CDC42EP1 GGA1 CACNA1I TYMP RN7SKP80 POLR2F SLC25A5P1 PIM3 NPTXR JOSD1 CSNK1E NOL12 FAM227A POLR3H ANKRD54 CDPF1 CCDC134 ARHGAP8 XPNPEP3 RRP7A SGSM3 LINC00634 GRAMD4 GTPBP1 ACO2 HDAC10 CELSR1 ODF3B TOMM22 BRD1 KLHDC7B TOB2 SLC16A8 RPL3 PHF5A CENPM DNAL4 ALG12 DENND6B PRR5-ARHGAP8 SNORD83A XRCC6 PMM1 SULT4A1 CARD10 TBC1D22A FAM83F SLC25A17 POLDIP3 EP300 MICALL1 TAB1 MIOX RNU12 CBX6 PRR5 PPARA ATF4 MIEF1 SREBF2 ATXN10 TMEM184B ADSL up
## chr6q23 0.0027473 0.0113397 -0.5221916 -2.213729 0 61 TCF21 EYA4 EPB41L2 SMLR1 IFNGR1 STX7 VNN2 LINC01010 VNN3 SAMD3 MYB-AS1 FTH1P26 SGK1 TBPL1 ARG1 COX5BP2 LINC00326 ALDH8A1 MYB MOXD1 VNN1 CCNG1P1 AKAP7 PDE7B TMEM200A BCLAF1 down
fgsea_plot(fgsea_res$res_c2, pathways_title='C2 curated genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0013736 0.0104291 0.7000836 3.448441 0 308 ZBTB7B ZNF692 HSF4 EIF3B KCTD13 UBAP2L SMG5 ATAD3A PHKG2 FBXL19 ATAD3B SMARCA4 RHBG ZNF598 FBXL18 POLM INTS1 QTRT1 SRCAP FBXO44 CAPN15 RCC1 CC2D1B ZMYND19 ZNF646 ARHGEF11 RNF207 RTKN LARP1 AGRN GFER USP21 SLC12A9 RNPS1 SH3BP5L MARK2 ATXN2L PPM1G SNHG3 EVI5L STK11 SRRM2 MOGS SETD1A SLC52A3 MTOR C7orf26 PDXP MIIP ZNF316 PICK1 LRCH4 MYPOP ABCF3 KAT8 SLC39A3 ZMIZ2 GIGYF1 SRRT SCAF1 TMEM63A LSM14B RANGAP1 L3MBTL2 UQCC2 ZNF444 HIP1R TRABD TRAF2 TCF3 RASSF7 SNAPC4 DENND4B FBXO46 AP5Z1 TMEM86B TNPO2 TMEM201 PTBP1 PHPT1 KMT2D XPO5 GRIPAP1 SETDB1 NPM3 TRMU PUS1 R3HDM4 CMTR1 REXO1 SUN1 ABCC10 EPN1 DAGLB KLF16 KHSRP ERCC2 ARMC6 ZC3H7B CACTIN MAP2K2 TMEM259 GAS5 NEURL4 DAZAP1 ILF3 TRRAP DPH7 FBRSL1 ABCA7 PIP5K1A PPP6R2 PPRC1 TBC1D22B ACIN1 U2AF2 SPPL2B SZT2 FXR2 HPCA CDC42EP1 GGA1 COPS7B ENGASE SMG7 CUL7 TICAM1 MAPK8IP3 POLR2F CSNK1G2 KCNK5 APBA1 GPC2 HNRNPU SBNO2 ZNF202 CIC NSUN4 GATAD2A CSNK1E SYMPK CPSF7 ARPC5L TNK2 HHLA3 ANKRD54 LTB4R URB2 AP5S1 CUL9 CLASRP SNRNP70 DDX11 PPP1R12C ZDHHC24 TAF1C SGSM3 ANKRD13D GRAMD4 CNTROB TEAD3 HDAC10 HIRA MEF2D TECPR1 TNPO3 PABPN1 NUP62 DRG2 WASH3P PPARD MSTO1 APBA3 FANCA LMNA CALR SUGP2 RPL18 BRD1 DHX33 FNBP4 LPAR2 LLGL1 PHF5A AMPD2 MRPS25 MCTP2 TTC13 MBD3 MDN1 ZNF524 GBA2 THOC2 TCHP HAUS8 RBM33 TCOF1 ZNF580 ZNF133 SLC4A11 DOT1L LEMD2 CDC42SE1 SF1 NSUN5P1 HDAC7 up
## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0015314 0.0104291 0.7597568 3.316904 0 105 SNRNP25 MRPS34 TBL3 TELO2 RPUSD1 RHBDL1 C16orf91 WDR24 POLR3K AXIN1 PIGQ JMJD8 TRAF7 UBE2I METRN THOC6 NME3 WDR90 ZNF598 RAB40C NUBP2 CAPN15 WFIKKN1 KCTD5 TSR3 CHTF18 RHOT2 MPG GFER EME2 NME4 ZNF205 ZNF213 NTHL1 CLDN6 PRSS22 NPRL3 CLCN7 DECR2 SRRM2 HAGH PKMYT1 MRPL28 TSC2 PRSS27 STUB1 GNPTG RHBDF1 NDUFB10 PAQR4 KREMEN2 TNFRSF12A LMF1 FBXL16 MSRB1 RAB11FIP3 FLYWCH2 FAHD1 HAGHL RPS2 HCFC1R1 MAPK8IP3 PRSS33 UNKL up
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 0.0013966 0.0104291 0.6809103 3.303265 0 256 CLPTM1L RAB25 BSPRY AURKAIP1 SMARCA4 GIPC1 BAIAP2L1 GSS RABEP2 MVP CC2D1A PWWP2B ST14 EPCAM ABCC3 MROH1 GALE EIF2B5 OXLD1 CCND1 CANT1 CIB1 TSTA3 JTB RABL6 ATP1B1 SRPK1 ZGPAT LMAN2 STARD10 ARRDC1 NADSYN1 DOHH MRPL14 EIF4G1 CRB3 PSD4 PACSIN2 TMEM129 TMEM63A ESRP2 PPDPF DNAJB2 SART1 TMEM30B KRTCAP3 RRBP1 TUBA4A F11R ARHGAP27 HIP1R MLPH EDF1 LSM7 GOLGA2 TTLL12 TMC6 POP7 MRPS18A TRAF4 EPS8L2 RNF126 RASEF MED16 SFN BZW2 ETFB PLEKHJ1 CHMP1A SGPP2 TOMM40 NET1 MT-ATP6 MRPL41 MUC1 QSOX1 CHMP4C TMEM259 MYO6 PPIA SIRT7 BPHL C8orf82 SCAMP2 TMC5 HDLBP MRPL52 MLLT6 LLGL2 C1orf116 NQO1 RALY ELF3 ICA1 FOXQ1 TEX264 TTC22 GFPT1 MFSD9 DHTKD1 FRK TJP3 MKNK2 OVOL2 EPHB4 ARSD ANKRD9 ERBB3 GSTK1 TNIP2 ESRP1 PSMB10 CNPPD1 ARPC5L ELL3 ACY1 TOP1 MYO10 GRTP1 MPST UQCRQ EIF5B TALDO1 PET100 RRP7A RPS6KA1 SGSM3 VPS37B ZMYND8 MARVELD2 C1GALT1 TACSTD2 NDUFAF2 AACS TOX3 SLC22A23 NOSIP ACAA1 KDELR2 NOP58 CCDC107 GPR160 ABHD17C RNF128 AGR2 GSTP1 UBALD2 MGLL AGR3 UQCR11 IMPA2 HM13 DOK4 UNC5CL TMEM125 FDFT1 CTBP2 PLS1 HDAC1 EHF IFI27 GNA11 FUT2 C19orf33 DDAH1 SLC35A3 up
## CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 0.0012870 0.0104291 0.6407627 3.263877 0 406 RHPN1 ZBTB7B FLAD1 HOOK2 EFNA4 CGN RAB25 RMND5B NOL3 BSPRY ELMO3 JMJD8 DLG3 PKP3 TMEM134 NME3 UBQLN4 RAB40C SPINT1 CAMSAP3 TFF1 NR2F6 RABEP2 SH2D3A GGCT USP18 IQCE PPP1R16A TRIB3 PWWP2B ST14 KIAA1522 TMPRSS13 EPCAM TM7SF2 ABCA12 ISG20L2 TSTD1 ZBTB42 PIP4K2C PROM2 LSR LAD1 SLC29A2 GOLT1A EPHA1 CRABP2 JTB TMED3 ROGDI SSH3 PGAP3 TMEM184A CNNM4 AP1M2 CYB561 SYNE4 ERBB2 LMTK3 SLC52A3 STARD10 ARRDC1 EPN3 TNKS1BP1 RHBDF1 ENSA TBC1D30 PAGR1 ESRP2 FAAH PPDPF CACNB3 PAQR4 TMEM30B SPATA2L F11R CLDN7 ARHGEF5 HIP1R MLPH CYHR1 SUOX ZNF74 PRSS8 OVOL1 GRHL1 TRAF4 CBLC RASEF AAGAB MARVELD3 KIFC2 HID1 MACC1 BCR MPP7 RAB11FIP4 TMEM45B SUN1 FAM110A RUSC1 MRPL41 MUC1 SIGIRR MAP7 CHMP4C MCCC2 TMPRSS2 MYO6 RBM47 SYNGR2 CDH1 SLC37A1 PATZ1 FOXA1 SCAMP2 TLE3 ZNF467 CDH3 PLXNA3 SPINT2 LLGL2 PDXDC1 RAB17 ARFIP2 CHMP2A ANXA9 TTC9 ELF3 ICA1 FKBP4 PRLR GSPT1 SMPDL3B TMEM79 ZXDC TJP3 SYTL1 MKNK2 SYT7 OVOL2 P4HTM GRB7 PCK2 C1orf43 SHANK2 C6orf132 CAPN8 ERBB3 GRHL2 DHRS13 ESRP1 TUFT1 SYMPK MAL2 MREG TNK2 ELL3 COG7 EPHB3 ALDH3B2 OCLN SEPHS2 KIAA0319L TRAPPC6A ARHGAP8 MGMT EXPH5 IDH2 SUCO PLCH1 CSAD BLVRB GRAMD4 MYO5C EPS8L1 TMEM41A MARVELD2 CREB3L4 TADA2B TRPM4 PGAP2 KIAA0556 TP53TG1 TMEM191A FAM214A HOOK1 INPP5J DCAF11 TTC39A S100A14 PRRG4 PRR15L TMEM183A CADPS2 ARFGAP2 TOX3 MSX2 PPP1R3D JUP SLC25A29 MYO5B PPCS SCYL3 PPM1H GPR160 CCDC6 SH3YL1 AGR2 AZGP1 DBP GPR157 ATP2C2 RAB3D ULK1 SFI1 IRF6 SERINC2 MYH14 ERP29 GPD1L PRKD2 MPZL3 CASZ1 GALNT6 IRX5 CXorf40A CDC42SE1 SORL1 ABAT C11orf80 MRFAP1L1 PLXNB1 KRT19 VRK3 ZNF165 SERF2 ALDH4A1 PLEKHA6 CCDC97 up
## LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 0.0014347 0.0104291 0.6847204 3.241532 0 202 SLC4A2 CLPTM1L PYGO2 INPPL1 FASTK DPP3 TAF6 FADD PDCD6 TMEM134 LY6E ADAR PMVK POLR2J CCDC127 METTL1 PPP1R16A NDUFS6 PC ARHGEF11 EGFR CDK5 ABCF2 DHCR7 HDGF USP21 GCDH CCT6A TSTA3 CCS JTB PRCC CLCN2 ALKBH4 B4GALT3 SLC12A7 EIF4G1 HAX1 CORO1B NUMA1 POLR2H PNN RMI2 ZNF3 TDRKH YKT6 ZNF74 NAT10 MBD6 PI4KB RAD23A DENND4B TSFM CCT5 MET CDK4 SETDB1 MAGEF1 IGSF8 FIGNL1 MRPL11 NDUFS2 DAP PARD3 MRPL9 AKT1 CERS2 NKX2-1 DUSP12 SEC61G GNB2 MRPL36 COPS6 LAMTOR1 NUDT1 SDHA PIP5K1A MCM7 PPFIA1 KDM2A PSMB4 DDIT3 TFDP1 ILF2 MRPL23 LPCAT1 PPP1CA DVL3 TUFT1 VEGFA MTRR BAZ1A CCDC85C NUBP1 SSR2 SLC39A1 GEMIN2 LANCL2 POLD4 TMEM191A ZSCAN21 RPS27 SHC1 S100A13 KCNH2 SRP54 PPP1R3D MAF1 MBIP AGO2 CCDC107 TPM3 SRD5A1 PMF1 FAM131A FAM177A1 POGZ MED15 TRIM44 CRKL MIPOL1 JPH1 RTN4R FASTKD3 MRPS17 SIVA1 P2RY6 S100A11 USP13 SNAPIN PUF60 PI4KA up
## CAIRO_HEPATOBLASTOMA_CLASSES_UP 0.0012151 0.0104291 0.6093901 3.173862 0 560 TBRG4 MLST8 EIF3B UTP14A PRPF6 MYBBP1A DDX56 FARSA EEF1D SMARCA4 GTF3C2 ZNF696 NR2F6 GGCT ATIC PARP1 RCC1 NCLN RFXANK EPCAM P4HB AP1G2 ABCF2 PDIA4 CIAO1 CCT6A APRT DDX41 MAD1L1 PFAS HMGA1 RRS1 DGKD TUBG1 TRAP1 TIMELESS CYC1 MAVS ENO1 PRMT5 CCT3 OSBPL2 SRPK1 MRPL12 LSM4 THAP4 SNRNP200 ACTR3B RANBP1 AHCY PSPH GPS1 IPO4 KIF22 UBE2C MRTO4 CDT1 NHP2 MRPS33 DDX27 FAM136A PAXIP1 NCL DDX42 STK25 NAT10 CHCHD2 POP7 RUVBL1 C1orf109 POLR1C NOP56 CBX3 NLE1 CHAF1A DNAJC4 MYL6B CCT5 MAN1B1 CDK4 RNF126 UPK3A CCNF IMP4 POLR3E BZW2 NPM3 AAMP TRMU PUS7 PUS1 GTF2F1 AATF SSRP1 TXNL4A RUVBL2 PRMT1 NUP205 POLD1 DNMT1 NOLC1 BSG DTYMK LIG3 ALDH18A1 CHEK2 DAZAP1 EIF2B4 SF3B3 ILF3 SEC61G PRDX4 TRRAP PDCD11 CCT7 E2F5 NONO TSR1 CPSF6 PSMB5 MRPS7 TRIM28 PTP4A3 HDLBP ERGIC3 MCM4 CCDC47 MCM7 APEX1 RPS21 CAD RPL36 PNKP RSL1D1 PRKDC NUP210 MCM2 MIS18A SNTB1 GTPBP4 SUPT16H MNAT1 CCT2 ILF2 CDCA8 TPD52L2 MAZ PLK1 NIP7 RPL11 C1QBP HSPD1 EXOSC2 TAF12 LRRC59 HSP90AB1 RPL8 DDOST CIZ1 GART UBE2S STOML2 AARSD1 LAPTM4B WDYHV1 CPNE1 HEATR1 RNASEH2A GRK6 MRS2 NUP93 EIF5B PHB NME1 TOMM34 BIRC5 SNRPB RPS3 GNL3 RPL37A RRM2 ARMC9 FBL SMARCB1 PDIA6 TCERG1 NUP85 IMPDH2 LANCL2 GMPR2 RPL24 MCM10 RPLP0 RPL10A KIF4A GCSH DGUOK CLNS1A FANCA NCAPG2 RPL19 RPS16 ARID3A LIG1 MMS19 RPN2 POLR2D PSMF1 RPL28 MKI67 RPL22 RFWD3 SLC39A4 RPL18 KIF20A PPAT RPL18A UBAP2 TIMM9 CIAPIN1 SAE1 ODF2 SAP130 FOCAD DDX39A CDC20 TPX2 KDELR1 HJURP UQCRH GLDC AURKA KIF2C SFI1 MDN1 SMARCC1 BYSL CCNB1 DNMT3A MCM3 OXA1L CKAP5 KIF18B PTK2 PABPC4 PLIN3 ENOPH1 NT5DC2 C8orf33 UTP18 SRSF1 HUWE1 KIF18A RPL14 RPS14 AURKB TOMM20 KPNB1 ACLY NEK2 MRPS27 KLHL7 BUB1 CDC6 WDR3 SUPT3H BOP1 BFAR CRELD1 UTP6 SF3A1 C20orf27 AGBL5 PPA1 PUF60 KRT19 XRCC6 PI4KA PRDX6 SPDL1 GINS4 CREB3L2 CENPN SNRPD1 BUB1B EZH2 MRPL15 NCAPD2 TGS1 CTSV LRPPRC FXN CENPF SRSF9 EIF3H IGSF1 MPZL1 ESF1 HMMR USP10 CCT4 CDC25A CCNB1IP1 SLC35F5 RPS6 OLA1 WDR12 CDCA4 THOC5 PQBP1 CSNK2A1 CPSF1 SNX5 RPL23 HOMER1 NAE1 YEATS2 EIF4E2 RPS8 CHEK1 SMC4 RBM12 NOP16 KIF23 DDX18 CANX TCEA1 MAPKAPK5 DLGAP5 POLR3D SEC23IP AP2B1 UTP20 TASP1 CKS2 HIC2 RFC4 ADSL CCNE1 FKBP10 COIL DLST NDC80 GINS1 KIF14 MTDH EEF1B2 CENPI CENPA HSF1 EMG1 TPGS2 TAF1D EIF2S2 TOP2A NCBP2 RPL4 CDC25C PRC1 DBF4 ACP1 PYGL NUSAP1 KIF15 ASPM KNTC1 CERS6 up
## REACTOME_METABOLISM_OF_RNA 0.0012107 0.0104291 0.6040275 3.162234 0 626 SNRNP25 TYW1 TBL3 UTP14A PRPF6 SMG5 GTPBP3 EDC4 CD2BP2 CSTF2 THOC6 ADAR POLR2J WDR4 QTRT1 METTL1 TRMT1 PSMD4 RPPH1 NOL6 BMS1 TSR3 PSME2 DDX23 USP39 WDR18 ISG20L2 NOC4L RNPS1 RRP9 RPL39L EBNA1BP2 TSEN54 PRCC NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 PRMT5 SRRM2 RRP1 LSM4 SNRNP200 DHX37 EIF4G1 LAS1L POLR2L TNKS1BP1 CTU2 POLR2H PELP1 SRRT SART1 PSMD3 ALYREF TRMT61A NHP2 GEMIN4 NSUN2 TRMT12 LSM7 TRMT44 NCL DDX42 SF3A2 NAT10 SUPT5H POP7 EXOSC6 NOP56 PSMC4 DCPS PTBP1 IMP4 CPSF4 TRMU PUS7 PRPF19 PUS1 GTF2F1 UTP3 TXNL4A NUP205 XAB2 SNRPA CHERP KHSRP ERCC2 SF3B2 AKT1 CNOT11 TRMT112 CTU1 ADAT1 SNRPE PSMC3 SF3B3 HSPB1 CSNK1D PSMA6 PDCD11 POLR2E UPF1 MT-RNR2 FTSJ3 TSR1 PSMB5 PSMA5 PSMD2 ADAT3 RPL38 THOC3 RPS2 AAAS RPS21 U2AF2 EFTUD2 MT-RNR1 NXT1 MPHOSPH10 RPP25 RPL36 LSM5 ELAC2 PARN METTL3 APOBEC3B NUP210 PSMB4 RPL37 NUP107 PRKCA GAR1 GSPT1 EXOSC10 MNAT1 TPR UPF3B SMG7 SRSF4 NIP7 RPL11 CWC25 POP1 PSMA7 PSMC6 EXOSC2 RPL8 PSME3 HNRNPA1 POLR2F EDC3 RPL13 RPLP1 HNRNPU SLBP PSMB2 PSMC5 NSUN4 WDR33 RPL12 RPL36AL CSNK1E SYMPK CPSF7 PSMB10 PAIP1 DDX49 NOL12 RPL35 IMP3 HEATR1 HNRNPUL1 PSMB6 GLE1 RBM28 XPOT NUP93 SNRNP70 DDX46 SRRM1 DHX38 IGF2BP3 LSM10 SNRPB RPS3 SNRPC RRP7A GNL3 DUS2 PSMD13 PSMB3 RPL37A PSMD11 POLR2A FBL FUS NUP85 GEMIN2 PABPN1 RPS5 NUP62 RPS15 RPL24 RPS27 RPLP0 SNRPD2 RPL27 TRMT6 RPL10A PABPC1 RPLP2 RPL27A SF3A3 CLNS1A PSMC2 RPL19 RPS16 ERCC3 SNRNP40 RNPC3 RRP36 POLR2D PSMF1 RPL28 RPL39 RPL41 RPL22 RPS20 NOP58 SNRNP35 RPL18 RPL31 RPL18A RPL30 ZMAT5 BUD31 RPSA TRIT1 GEMIN5 PRPF8 RPS28 FAU SMG8 RPS29 DDX39A RPL3 PAN2 PPIH PHF5A ANP32A EXOSC1 RPS11 NUP188 RPS12 NOL9 SNRPF BYSL THOC2 DHX9 RTCB ZFP36L1 SEC13 TFIP11 RPP38 UTP18 SRSF1 HNRNPF PSME1 RPL14 RPS14 ELAVL1 RPL13A HNRNPA2B1 ERI1 WDR3 SF3B5 SNRPD3 BOP1 SF1 UTP6 PRPF4 POLR2I HNRNPM SF3A1 SUGP1 PPIE PUF60 PPIL1 RPS10 DCAF13 RPL26L1 RPL29 NUP214 RPL32 GEMIN6 U2AF1L4 SNRPD1 UBC PPP2R1A RPS24 URM1 LCMT2 TGS1 CDC5L RPL26 POM121C SRSF9 TRMT5 HSPA8 NUP133 SMG1 PSMD8 RPS7 CHTOP PUS3 CSTF1 RPL35A ZC3H11A RPL9 A1CF TP53RK POLDIP3 RPS6 RAE1 WDR12 THOC5 RPL23A NUP88 ZBTB8OS RBMX RPS4X PDCD7 LTV1 PQBP1 HNRNPA0 TRMT61B IGF2BP1 CPSF1 UBA52 SMG9 WDR43 RPL23 CNOT2 PSMA3 SNRPG MAGOH NUP155 POLR2C RPS15A PSMD9 RPS27A RPS26 GEMIN7 RPS8 TSEN15 NOP10 PSMC1 up
## REACTOME_TRANSLATION 0.0013850 0.0104291 0.6362028 3.101789 0 262 MRPS34 MRPL55 EIF3B MRPL24 AIMP2 AURKAIP1 FARSA EEF1D MRPL4 TARS2 DAP3 APEH MRPL20 MRPS26 EIF3C MRPL33 MRPS2 MRPS15 TUFM EARS2 EIF2B5 AARS2 RPL39L MRPL12 MRPL14 MRPL28 EIF4G1 ERAL1 GADD45GIP1 HARS2 CHCHD1 MRPS33 MRPS18A TSFM EEF1A2 MRPS6 MRPL11 MRPL27 EIF3I MRPL41 MRPL9 MRPL21 MRPL49 EIF3G TRMT112 EIF2B4 SEC61G MRPL36 MT-RNR2 MRPS7 MRPS5 MRPL52 RPL38 RPS2 MRPL17 RPS21 MT-RNR1 NARS2 RPL36 RPL37 GSPT1 MARS2 MRPL23 SRP68 RPL11 MRPL37 MRPL51 RPL8 DDOST RPL13 RPLP1 MRPS23 MRPL48 FARSB MRPS12 RPL12 RPL36AL IARS2 RPL35 EIF5B SRPRB MRPS35 RPS3 MRPL2 SSR2 MRPL38 RPL37A MRPS16 MRPL3 RPS5 SEC61A1 RPS15 RPL24 RPS27 RPLP0 EIF3D RPL27 RPL10A PABPC1 RPLP2 RPL27A MRPL34 RPL19 RPS16 SRP54 RPN2 MRPS21 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA MRPS11 AIMP1 RPS28 PARS2 FAU RPS29 RPL3 MRPS25 MRPL10 EIF3A RPS11 EEF2 RPS12 OXA1L EIF4EBP1 MRPS17 RPL14 RPS14 RPL13A MRPS27 PPA1 RPS10 RPL26L1 RPL29 RPL32 RPS24 MRPL15 MRPL54 YARS2 RPN1 RPL26 EIF3H LARS2 PTCD3 RPS7 RPL35A RPL9 MRPL43 EIF2B3 RPS6 FARS2 RPL23A RPS4X MRPS28 UBA52 SEC11C RPL23 MRPL44 RPS15A RPS27A RPS26 RPS8 up
## MANALO_HYPOXIA_DN 0.0013793 0.0104291 0.6281606 3.078336 0 270 TELO2 UTP14A POLR3K AIMP2 FAM86C1 LETM1 WDR4 POLD2 ATIC PARP1 NCLN TTLL4 DDX23 USP39 ABCF2 DHCR7 CIAO1 SRM RRP9 RPL39L EBNA1BP2 PFAS HMGA1 RRS1 TUBG1 PWP2 PRMT5 RRP1 SLC25A10 AKAP1 PKMYT1 CLPB FEN1 MFN2 RANBP1 POLR2L IPO4 PRMT7 SRRT GRWD1 URB1 HMBS MRTO4 GGT1 PCYT2 FAM136A LRP8 NAT10 UMPS POP7 RUVBL1 LMNB2 RSAD1 NOP56 TSFM NLE1 NVL CHAF1A CCNF PUS1 NUP205 NOLC1 ARMC6 DDX19A ILF3 TSR1 RRP1B MCM4 ASF1B CAD NARS2 AMDHD2 BCS1L SNAPC5 PA2G4 TOR3A MCM2 GTPBP4 METTL2B MAZ PAK1IP1 CTPS1 POMT2 C1QBP ZWINT EXOSC2 GART PSME3 UBE2S HNRNPU MRPS12 PAIP1 NOL12 SLC5A6 HEATR1 URB2 RBM28 DDX11 PHB NME1 SLC25A15 PSMD11 RRM2 FANCG SLC1A5 FUS NUP85 GEMIN2 MCM10 PARP2 GCSH PPARD SCLY UBIAD1 FBXO42 PPAT WDR74 TIPIN DGCR11 STIL TPX2 HJURP NUP188 BYSL MCM3 GPD1L FASN TUBGCP4 CDC6 BOP1 C20orf27 ELK1 FERMT1 SPDL1 GEMIN6 EXO1 CD3EAP UCHL5 CENPN RRP15 SNRPD1 BRCA1 DHFR FXN MELK POLA2 DHCR24 NCAPD3 HEATR3 CPN2 EIF2B3 MCM5 WDR12 SAR1B ELOVL6 GMNN PPIF NEK4 NIF3L1 MAP2K3 NOP16 NASP KIF23 DDX18 CISD1 SEC23IP UTP20 POLE2 PRPS1 TUBB4B CCNE1 MRPL46 GINS1 CCNE2 up
## REACTOME_RRNA_PROCESSING 0.0014993 0.0104291 0.6629825 3.075180 0 184 TBL3 UTP14A NOL6 BMS1 TSR3 WDR18 ISG20L2 NOC4L RRP9 RPL39L EBNA1BP2 NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 RRP1 DHX37 LAS1L PELP1 NHP2 NCL NAT10 EXOSC6 NOP56 IMP4 UTP3 TRMT112 CSNK1D PDCD11 MT-RNR2 FTSJ3 TSR1 RPL38 RPS2 RPS21 MT-RNR1 MPHOSPH10 RPP25 RPL36 ELAC2 RPL37 GAR1 EXOSC10 NIP7 RPL11 EXOSC2 RPL8 RPL13 RPLP1 NSUN4 RPL12 RPL36AL CSNK1E DDX49 NOL12 RPL35 IMP3 HEATR1 RBM28 RPS3 RRP7A GNL3 RPL37A FBL RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 RRP36 RPL28 RPL39 RPL41 RPL22 RPS20 NOP58 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 FAU RPS29 RPL3 EXOSC1 RPS11 RPS12 NOL9 BYSL RPP38 UTP18 RPL14 RPS14 RPL13A ERI1 WDR3 BOP1 UTP6 RPS10 DCAF13 RPL26L1 RPL29 RPL32 RPS24 RPL26 RPS7 RPL35A RPL9 RPS6 WDR12 RPL23A RPS4X LTV1 UBA52 WDR43 RPL23 RPS15A RPS27A RPS26 RPS8 NOP10 up
## LI_AMPLIFIED_IN_LUNG_CANCER 0.0015198 0.0104291 0.6644600 3.044929 0 167 EEF1D PDCD6 UBE2I LGALS3BP SPINT1 TFF1 SLC22A18 EIF3C MDK ABCC3 P4HB TUFM HDGF PHLDA2 APRT NME4 TSTA3 CRABP2 JTB ENO1 CCT3 ATP1B1 ERBB2 CDK2AP2 HAX1 UBE2C HSPA5 CBX3 EEF1A2 TRAF4 CCT5 SFN TRIM2 PKM DAP ALDOA MUC1 SLC7A5 SNRPE SYNGR2 HSPB1 PRDX4 SOX4 CD46 CDH1 TRIM28 SDHA RPL38 RPS2 SPINT2 SCNN1A RPS21 NQO1 PTPRF DPP7 PSMB4 RPL37 HSPD1 RPL8 DDOST ERBB3 RPL13 LAPTM4B VEGFA TOP1 RPL35 YIF1A LCN2 TALDO1 NME1 UGDH IDH2 RPL37A ENC1 RPS5 RPS27 SNRPD2 RPL27 RPL10A PABPC1 RPL27A RPS16 KRT7 GALNS RPL28 CALR JUP RPS20 CKAP4 RPL31 RPL30 CLDN9 ASCL1 MARCKSL1 KDELR1 UQCRH AKR1A1 GPI PFKP up
## SANSOM_APC_TARGETS_REQUIRE_MYC 0.0014306 0.0104291 0.6382462 3.033135 0 209 TELO2 MYBBP1A GTPBP3 GIPC1 WDR4 QTRT1 METTL1 ZBTB48 PPP1R14B DPH2 ZMYND19 SMYD5 SAPCD2 CCDC86 SRM RRP9 SLC29A2 ZNF213 SMPD4 TK1 TIMELESS PPAN NELFA THOP1 GAS8 KNOP1 D2HGDH WDR34 GRWD1 MUTYH ZNF444 ZSWIM3 TRMT61A NHP2 LRP8 TNFRSF12A ARX LMNB2 SIGMAR1 NOP56 RAD23A FHOD1 DUS3L CDK4 TP53 WDR62 SRD5A3 NOLC1 POLR1A DTYMK RCC2 SHMT2 SLC35B2 ADAT1 HAGHL NTMT1 PTOV1 SOX4 CCT7 POLE MCM7 AAAS CAD GAR1 LDB1 SYTL1 METTL2A RANGRF TUBB2A FARSB MUS81 DDX49 RNASEH2A SHMT1 EMC8 NME1 PRSS41 AAR2 MRPL38 FBL RAI14 HIRA LANCL2 TMEM141 DRG2 ANKRD39 STOML1 ATG9B CREBBP RPL31 IFFO2 ALKBH2 GEMIN5 CDC42BPA TXNRD2 NFS1 RAD54L EXOSC1 MBD3 MDN1 SNRPF SMARCC1 MCM3 DENND6B PABPC4 TFIP11 SIVA1 NSUN5 EPHB2 LHPP MVK NBEAL2 PMM1 USP20 VEZT BUB1B ERCC1 SLC1A4 CITED1 SFSWAP PDXK HES6 RNASEH2C CCT4 PHGDH TRIB1 DDAH1 TP53RK up
## WELCSH_BRCA1_TARGETS_DN 0.0015291 0.0104291 0.6778156 3.027402 0 127 EIF3B UBAP2L AIMP2 PHKG2 EDC4 FARSA SMARCA4 GTF3C2 NME3 AP3D1 ATIC BMS1 RCC1 ALG3 POLRMT SRM HRAS CCND1 TRAP1 CYC1 PWP2 SRPK1 MOGS SEC24C LMNB2 PMPCA RASSF7 CHAF1A CDK4 AGPAT2 SSRP1 CDC37 NMT1 POLD1 CLTA NOLC1 SF3B2 SLC7A5 CHD4 PDCD11 SOX4 HDLBP RRP1B APEX1 CAD FKBP4 MCM2 CTPS1 MGST1 MLEC ANXA11 MRPS12 HK1 RPIA SNRNP70 DDX11 GALK1 TAF1C SLC1A5 SSBP1 GCSH SF3A3 CDC25B CKAP4 PPAT SCAP NUP188 BYSL PABPC4 TCOF1 EZR FASN BOP1 POLG DDT NUP214 PKN1 DANCR FDFT1 PIEZO1 SAFB NPIPB3 RABEPK DHCR24 RAE1 UBL4A KRT6B up
## VECCHI_GASTRIC_CANCER_EARLY_UP 0.0012837 0.0104291 0.5903113 3.005065 0 403 EFNA4 EIF3B DPP3 ISG15 CEP72 PDCD6 SMARCA4 ZFP41 WDR90 PMS2P5 GSS IFI6 ITPA PABPC1L TNRC18 BMS1 PFDN2 CDC34 GDF15 UBE2T FAM50A EBNA1BP2 HMGA1 SEMA4B RRS1 AIFM2 TK1 CYC1 ENO1 NELFCD CCT3 ATG16L1 RP9 PDP1 FEN1 TRUB2 RANBP1 UBE2C TUBA4A MRTO4 ALYREF CLDN7 SCYL1 APEX2 TFAP2C LRP8 OVOL1 POP7 NOP56 PCBD1 MSRB1 MARVELD3 TMED9 XPO5 MACC1 PUS7 AATF RUVBL2 FIGNL1 PRMT1 TMEM45B ZNF511 CCT6P3 C12orf66 WRNIP1 ATP11A GAS5 ATAD2 MYBL2 HSPB1 TMC5 THOC3 RASGEF1A MCM4 CDH3 MCM7 LIF TIMM13 RPS21 CDK12 SPIDR EFTUD2 ILDR1 KRT18 ADORA2B IDH3B MCM2 GTPBP4 MUC3A POP1 ZWINT PSMA7 F12 RPL8 STK31 LAPTM4B UHRF1 RNF123 CDCA7 ZNF117 LCN2 NUP93 ARHGAP8 RBM42 NME1 BIRC5 SNRPB FOXM1 CDCA5 C12orf10 RRM2 MRPS16 UPP1 TACSTD2 SHKBP1 MCM10 PGRMC1 TRMT6 MYOF KIF4A SAC3D1 CDR2L NCAPG2 GPRC5A COMMD5 CDC25B TRIM47 MSX2 KRT7 DHX8 MKI67 JUP SLC39A4 KIF20A AGO2 ITGA2 ASS1 BOK TFAP2A CDC20 TPX2 RPA3 CENPM SFXN4 PMEPA1 HUS1 PRELID1 AURKA TBCB RBM19 PI3 SLC52A2 BYSL CCNB1 JPH1 PTTG1 KIF18B PFKP HOXC6 ZNF592 DSCC1 ANLN POLD3 C8orf33 MRPS17 NSUN5 EPHB2 NMU ZDHHC11 PTMA EFNA2 SLC4A11 NEK2 BUB1 GPSM2 PFDN4 CDC6 S100A11 PRPF4 TIMM17A DCAF13 HOXA10 FERMT1 BRIP1 NEAT1 EML4 SPDL1 ZNF367 GINS4 STRIP2 CENPN SNRPD1 BUB1B EZH2 RUNX1 BRCA1 ATP10B DHFR RPN1 CTSV PIEZO1 ABHD12 CENPF MELK HSPA8 NUP62CL HMMR KLK10 LACTB2 MCM5 LYAR MMP7 WDR72 MRPS28 LAMA5 SNX5 CEP55 PDZK1IP1 FOSL1 NUP155 CSPG5 CHEK1 DEPDC1B SMC4 NOP16 NASP IER5L DLGAP5 AJUBA IFITM1 CKS2 SATB2-AS1 CCNE1 NDC80 GINS1 KIF14 FAM133B CENPA ZIC2 NPIPA1 CFTR IFITM3 FBXO31 CDCA2 TOP2A LAMC2 NCBP2 PRC1 NUSAP1 KIF15 ASPM S100A6 PRR11 KCNN4 GTSE1 CENPH MRPL13 NTPCR KIF26B MUC13 WDR77 FANCD2 ECT2 TRIP13 CDK1 up
## LIM_MAMMARY_STEM_CELL_DN 0.0013055 0.0104291 0.5931868 3.000486 0 387 COASY CGN RAB25 SMIM1 RER1 HLCS TSPAN17 STAP2 MAPK13 ELMO3 PACSIN3 FADD OPLAH DLG3 GIPC1 REEP6 LGALS3BP ANO9 BAIAP2L1 SPINT1 CAMSAP3 PIGO SIL1 MVP SLC22A18 EVPL ST14 KIAA1522 TMPRSS13 EPCAM TM7SF2 AP1G2 DHCR7 GALE LSR HDHD3 OXLD1 CIB1 ARHGEF16 ATP6V0E2 TMED3 SSH3 PGAP3 DECR2 AP1M2 ATP1B1 TMEM54 HAGH ERBB2 STARD10 ARRDC1 ACOT8 MPI CRB3 FAAH TDRKH STAT6 PPL ZDHHC12 CLDN7 SUSD4 EPB41 MLPH OS9 ARPC1A TMEM62 GRHL1 RASSF7 RREB1 BDH1 CEACAM1 CBLC IFI35 MARVELD3 SNX8 HID1 PAFAH1B3 RAB11FIP4 STXBP2 FBXO6 FAM110A WFDC2 RORC MRPL9 MUC1 SIGIRR TIRAP MCCC2 TMPRSS2 ADAT1 RBM47 CDH1 SLC37A1 FOXA1 NUDT1 TPCN1 CHCHD5 ILDR1 KRT18 PTPRF FGF13 NUP210 ELF3 ICA1 PRLR ZSWIM4 ALG8 SDSL RAB3IP FRK MBOAT1 TOM1L1 TJP3 GRB7 ATG2A ERBB3 SLC39A11 GSTK1 PNPO ALAD TUFT1 PYROXD2 KRT8 HMGXB4 CORO2A BATF ELL3 SLC5A6 ACY1 GRTP1 DTX3L PRKCZ GLE1 RNASEH2A NDUFV3 SHMT1 ALDH3B2 C1orf210 KIAA0319L GOLM1 TRAPPC6A BCL3 ZDHHC24 SFXN1 SGSM3 RFX1 MYO5C TMEM41A TCIRG1 CREB3L4 CXCL17 HDAC10 C1orf56 PGAP2 MRPS21 RPL22 ZSCAN20 MYO5B SNRNP35 IVD ZFAND2B TRIM68 SCYL3 PPM1H TFCP2L1 ABHD17C SLC16A5 PXMP2 TFAP2A TST PAK1 NGEF PPP1R1B BARX2 ZNF524 LRBA RAD51D MIF4GD DHRS4 MYH14 PSME1 CASZ1 RMDN3 SORL1 ZNF750 ALDH5A1 HDAC11 KRT19 VRK3 KIF1B LIPH SLC9A3R1 PKN1 TMEM125 NCOA2 GOLPH3L BTC UROS THNSL2 SPDEF CTPS2 DHCR24 PLEKHG3 C1orf50 SLC35A3 BCL2L13 HTATIP2 DBNDD2 WNK4 PDZK1IP1 ALKBH6 CPT2 TANGO2 SLC5A1 DHX32 HPN MAPK9 DNAJC12 UNC93B1 PAOX SLC25A35 ISG20 RNF135 TLR3 TRAM1 up
## LU_EZH2_TARGETS_UP 0.0013986 0.0104291 0.6139698 2.980867 0 257 NUDCD3 RPUSD1 RMND5B PUSL1 TSPAN17 ISG15 SHARPIN TLCD1 THOC6 NME3 PMVK PEX16 ZNF629 AP1S1 MTX1 PSMD4 LONP1 PPP1R14B ZNHIT1 TRIB3 TYSND1 KLHL35 MFSD3 COMTD1 MPG TRIP6 OXLD1 SNHG11 PGAP3 PARD6A FAM71E1 LMTK3 FOXK2 PDXP TCF20 STUB1 ENSA PAGR1 F11R CLDN7 PODXL2 ELFN2 LSM7 NCAPH2 RPS6KB2 RUVBL1 ZCCHC3 RPS19BP1 WASH2P MYL6B IRF7 ISOC2 CBY1 IFI35 PIH1D1 ZP3 ETFB KRTCAP2 HES4 PLEKHJ1 LAMTOR4 NOLC1 MEX3D SIGIRR OGFR HAGHL PSMC3 ADAP1 MIEN1 PRDX4 BCAS4 C8orf82 NUDT1 PFKL UNC45A THOC3 AMDHD2 RPL36 JOSD2 DDIT3 NENF TOR3A SDC4 DPM3 BST2 LPCAT1 HCFC1R1 MKNK2 MAPKAPK3 HSD11B1L SCAND1 TRAPPC12 PCK2 ZDHHC16 IFIT1 CYB561D2 WDR83 TUFT1 PSMB10 C1orf210 MGMT RPLP0P6 ECHDC3 RPAIN ENDOG ACO2 TMEM141 TOMM22 S100A13 SURF2 LMNA TRIM47 CBR1 WDR74 CCDC107 ZMAT5 ALKBH2 BOK ODF2 TESK1 PHF5A PPP1R1B AHSA1 RAD51D PRMT6 ZNF133 TMEM216 COX14 CPM UQCR10 GANAB OCEL1 CSK B4GALT1 SERF2 HABP4 IFIT3 GUCD1 MAFA HDAC1 IFI27 GNA11 PHGDH UBE2L6 C1orf50 RHOF KLHDC9 G0S2 NAA38 RGS19 C2CD2 SDHC POLR2C ATOX1 up
## WONG_EMBRYONIC_STEM_CELL_CORE 0.0013661 0.0104291 0.6015126 2.973300 0 318 DPP3 POLR3K MAPK13 FARSA MRPL4 DAP3 ACAD8 PARP1 RCC1 MRPS2 PDIA4 CDC34 TRIP6 NME4 RNPS1 NTHL1 CCND1 PPM1G TIMM44 EBNA1BP2 CRABP2 NOP2 STIP1 EIF6 ENO1 MRPL12 LSM4 KIF22 ECHS1 NDUFB10 MRTO4 NDUFB7 FDPS NHP2 FAM136A NCL POP7 RUVBL1 CBX3 CHAF1A CCT5 CDK4 TP53 CCNF PUS1 HNRNPAB RUVBL2 PRMT1 IPO9 POLD1 PPP4C MRPL11 SNRPA NDUFS2 DNMT1 EIF3I DTYMK RCC2 NDUFAB1 CHEK2 MYBL2 NONO NIPSNAP1 PSMB5 PSMA5 GNA14 THOC3 MCM4 MCM7 APEX1 TIMM13 LSM5 PA2G4 NUP107 MCM2 CDCA8 HSPA9 PLK1 NIP7 MRPL37 PSMA7 BAX RAD23B GART PSME3 HNRNPA1 POLR2F BANF1 RPL13 STOML2 PDHA1 PSMB6 CDCA7 EMC8 SEPHS2 PHB UGDH BIRC5 NDUFA11 LSM10 RPS3 GNL3 SLC25A5 CDCA5 RRM2 FBL TIMM8B GEMIN2 NLN RPS5 RPS27 RPL10A KIF4A PABPC1 ETFA RPL27A RPS16 RAB34 SNRNP40 MID1IP1 RPL22 KIF20A SERPINH1 RPSA CDC20 PHF5A RPA3 EIF3A UQCRH ORC1 ALDOC GLDC EEF2 AURKA RPS12 DHX9 MCM3 EIF4EBP1 CLPP TCOF1 HADH NT5DC2 UTP18 MRPS17 ERP29 AURKB NEK2 COX5B BRIX1 BUB1 CDC6 WDHD1 UQCR11 GLO1 TMEFF1 KPNA6 FH UBE2V2 CTNNA1 GEMIN6 EXO1 BTF3 SNRPD1 BUB1B MRPL15 NCAPD2 HDAC1 PCNA LMNB1 MCM5 ELOVL6 GMNN MRPS28 SNX5 TEAD2 SDHC RPS8 NOP10 CHEK1 SMC4 NASP HNRNPL KIF23 DDX18 CISD1 DLGAP5 DARS2 E2F3 CKS2 POLE2 PRPS1 ADSL NCAPH TGIF2 NDC80 up
## MARTENS_TRETINOIN_RESPONSE_DN 0.0011820 0.0104291 0.5613304 2.963108 0 722 TBRG4 PSMG3 FLAD1 MRPS34 GPATCH4 TELO2 COASY PUSL1 MYBBP1A AIMP2 FADD DDX56 FARSA ZBTB45 YDJC TLCD1 METRN MRPL4 PGP NME3 ZNF512B ZNF598 FBXL18 ZNF629 POLD2 APEH TXNDC17 MTX1 METTL1 GGCT AK2 ZBTB48 MANEAL RECQL4 WFIKKN1 TRIB3 TYSND1 ZNF646 CABLES2 MFSD3 COMTD1 TM7SF2 NUDT16L1 SLC2A4RG TFAP4 TUFM LRRC14 HDGF TRIM41 NECAB3 FKBP2 EME2 CCT6A SNHG12 APRT SRM TIGD5 C19orf48 RPL13AP20 SLC29A2 OXLD1 NTN3 ATXN2L HMGA1 RRS1 SNHG11 MALSU1 MRPL12 PKMYT1 NT5C DDX51 CYP27B1 ERAL1 CORO1B VPS9D1 ACD TMEM129 POLR2L ZSCAN32 PTGES2 SCNM1 SOX12 PNN ACADVL DNAAF2 NDUFB10 PAQR4 GRWD1 ATG4D HMBS MUTYH CDT1 TMEM208 GEMIN4 FAM136A UMPS CHCHD2 RPS6KB2 POP7 CDK16 DCXR SIGMAR1 DHPS POLR1C ZCCHC3 ZNF785 NOP56 RAD23A ZNHIT2 HSPA5 CBX3 NLE1 MYL6B CCT5 ROMO1 E2F1 IMP4 NPM3 PRRG2 MAGEF1 PUS1 THTPA UTP3 SCO2 PRMT1 DNASE1L2 MRPL11 NOLC1 BRICD5 ARFRP1 CERS2 SLC35B2 EIF3G ITPKA PGLS SNRPE HAGHL PPIA SYNGR2 HSPB1 CSNK1D PTOV1 SOX4 C8orf82 COPS6 SSNA1 NONO ABHD14A TMEM186 TSR1 MRPS7 TRIM28 TBCC TIMM13 PRDX5 WDR73 NXT1 CHRNG THAP7 RPL36 LSM5 RSL1D1 CHMP2A IDH3B ZNF628 PHF23 PA2G4 RPL37 DDIT3 BABAM1 KEAP1 PRR22 MYL5 RHBDD3 MAZ PLK1 WDR6 FBXW9 ZNF513 HCFC1R1 NIP7 RPL11 MRPL51 NEIL1 BAX HSPD1 RPL21P28 PAICS HSP90AB1 MGST1 DRAP1 TRNAU1AP PSME3 C1orf43 DDN HNRNPA1 C6orf132 KAZALD1 CARNS1 IRF2BP1 HNRNPU STOML2 CYB561D2 TUBA1C SPRYD4 FAM201A REC8 DDX49 TAF7 ELL3 FGFBP3 RPL35 MORN1 TRIM65 CDCA7 TSPAN31 LRRC41 ZNF276 EIF5A UQCRQ TMUB2 BIRC5 NME1-NME2 NDUFA11 RPS3 HOXC11 MRPL2 RRP7A GNL3 PROCA1 FAM89B MLX COX4I1 GLS2 ANKRD13D RPL37A RRM2 IRF2BP2 MRPS16 SLC1A5 TIMM8B ENDOG RNF167 CREB3L4 MKRN3 HDAC10 IMPDH2 PABPN1 RPS5 RPL24 RPS27 RPLP0 HPS6 RPL27 RPL10A RNH1 SSBP1 MEPCE PABPC1 ODF3B TMEM179B TMEM102 CLNS1A MRPL34 HOXA11 RPL19 RPS16 ELOVL1 RNPC3 MAML1 CALR MXD3 METTL18 MID1IP1 MAN2C1 RFWD3 COX17 TMEM258 BLOC1S3 SNRNP35 PPCS RPL18 PTP4A1 MFAP1 RPL31 RPL18A MGAT2 RPL30 RPSA SLFN13 TIMM10 MARCKSL1 RPL3 DBP KCNJ14 SNORA44 COX7C CENPM CNPY2 FAM120AOS AURKA MBD3 RPS12 SMARCC1 MCM3 CA14 MIF4GD ZFAS1 PRMT6 NT5DC2 C8orf33 SRSF1 ERP29 HNRNPF HINT1 TMEM216 RPL14 RPS14 PTMA IL17RE RPL13A HNRNPA2B1 PCIF1 MMACHC TROAP IQCC MPLKIP HNRNPM SLIRP CLIP1 SNAPIN RPS10 RPL29 NDUFAF3 PPIB SPHK2 RPL32 ZNF324 ARVCF CD3EAP EXO5 UCHL5 TARDBP RPS24 C6orf62 RPL26 C1QL4 HSPA8 PCNA EEF1A1P9 FTH1 CCT4 PRSS53 CHMP4A RPL9 TYMS ZNF79 TP53RK PNPLA2 KLHDC9 GMPPB CACYBP RPS6 UBL4A RPL23A RNF126P1 RBMX RPS4X NAA38 LETMD1 HNRNPA0 NUDT19 MC1R COCH CEBPB HIGD2A SNX5 CIRBP RPL23 CITED2 ANPEP FOSL1 up
## SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 0.0012594 0.0104291 0.5766931 2.949902 0 444 DVL1 DUS1L TAF6 CD2BP2 FARSA SMARCA4 GIPC1 GSS B4GALT7 ZNF212 PSMD4 CTTN PARP1 RECQL4 NDUFS6 NDUFS8 PSME2 CDK5 DHCR7 WRAP73 GFER SLC12A9 FKBP2 POLRMT GALE APRT NME4 MAD1L1 DECR2 PPAN RRP1 AUP1 HAGH LSM4 CDK2AP2 SNRNP200 FDXR ACOT8 AHCY DEAF1 KIF22 SOX12 ENSA UBE2C SART1 HMBS MUTYH NDUFB7 GPX4 FDPS APEX2 GOLGA2 SF3A2 GTF3C1 SUPT5H TMC6 DCXR RREB1 GNL2 MYL6B PRDX2 TP53 CDK11B SFN ZP3 CCNF SPG7 CRCP BCAT2 CHMP1A IMPDH1 ARF1 DNASE1L2 STXBP2 TOMM40 NUTF2 NET1 KHSRP TARBP1 B3GAT3 VPS4A MAP2K2 TRA2A DAZAP1 PGLS SGTA HSPB1 EIF4G3 NONO NUDT1 COPG1 PSMB5 NDUFS5 PIAS4 POLE TECR PARK7 TACC3 DROSHA PEX6 RPL36 RALY MLF2 RPL37 NENF B4GALT2 TEX264 BRD8 DPM3 MRPL23 LDB1 HSPA9 ENO3 C1QBP BAX WWP2 NDUFA1 SCAND1 HERC2 PCK2 GBA HNRNPA1 HTT BANF1 CSNK1G2 XRCC2 HNRNPU TUBB2A XRCC1 CSNK1E CNPPD1 PAIP1 ACY1 STAT2 HHLA3 PABPC3 IL27RA GRK6 COX6B1 MPST UQCRQ RRP7A PSMD13 PSMB3 COX4I1 RPL37A PIN1 PEX14 CYP51A1 TCIRG1 CYB5B MEF2D PGAP2 KCNK1 SGPL1 TXN2 RPLP2 SCLY RPL27A APBA3 RGS14 FANCA RPL19 NARF ARID3A SNRNP40 DPF2 STOML1 IFNAR2 RPL39 ZNF544 IVD COX6C KIF20A PTP4A1 MZF1 TSPAN3 PMF1 ARHGAP1 FKBP3 RPS28 TESK1 FAU MARCKSL1 CDC20 SMARCD2 ARID4B AURKA AKR1A1 MBD3 ARF5 ICMT PTTG1 EIF4EBP1 TCOF1 ENOPH1 AP1B1 MEA1 DPAGT1 NDUFB1 PTMA HNRNPA2B1 COX5B EZR TROAP PHKA2 STT3A MORF4L2 TBCA S100A11 POLR2I RAB1B CLIP1 POLG CNPY3 CSK UCP2 B4GALT1 NFE2L1 SERF2 PPIB DDT PKN1 SNRPD1 TTF2 EZH2 ERCC1 UQCRC1 YARS2 RPN1 HDAC1 CENPF POLA2 SAFB KAT5 NPIPB3 CFDP1 RPS7 ACOT7 NDUFA2 DHCR24 up
## AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 0.0013774 0.0104291 0.6001446 2.947680 0 276 ZNF623 ASL TAF6 PRPF6 CEP72 EEF1D SHARPIN PDCD6 OPLAH INTS1 YTHDF1 PVT1 NDUFS6 ZNHIT1 NUDC GID8 LMTK2 SLC12A9 THEM6 TAF4 MAD1L1 TSTA3 ZC3H3 CYC1 MAFK BECN1 OSBPL2 ZGPAT EPN3 SMURF1 IRF3 AP4M1 BRD9 GRWD1 GSDMD UCKL1 ZNF444 CYHR1 ARPC1A SLC35B1 EML2 FBXO34 RSAD1 SPATA20 TCFL5 CRCP EXOC3 PLOD3 NMT1 PON3 RUVBL2 PRMT1 CLTA ASNS EPN1 XYLT2 ARFRP1 GYS1 FIS1 GNB2 TRRAP SDHA ARPC1B RPS21 U2AF2 SS18L1 MICALL2 GPER1 TPD52L2 LPCAT1 NFKBIB PSMA7 BAX PMS2P1 LRRC59 ZNF787 ZKSCAN5 PSME3 PNPO PAK4 AARSD1 MRPS12 WDYHV1 COA3 TMEM248 G6PC3 NAPA SNRNP70 PHB CREB3 TMUB2 NME1 CBX1 PAF1 ZDHHC24 MLX PON2 TMEM8B SLC1A5 ORAI2 NUP62 SLC26A4 SNAPC1 SNRPD2 PPP1R13L RPL27 CDKN2A ACSF2 ARHGAP35 LIG1 NR1H2 PPP1R3D NOSIP STRN4 SLC39A4 RPL18 PLEKHA4 DBP KDELR1 SLC52A2 LHB PTK2 KTN1 SYT5 ZNF580 UTP18 PRKD2 RPL13A KPNB1 ACLY WDR3 WDHD1 NUCB1 CNPY3 NSF OPA3 DDT CD3EAP TTF2 PCTP ATP6V0A1 VPS28 KCTD7 SNF8 PSMD8 ZNF146 PLEKHG3 MBOAT7 RGP1 SLC25A13 CASD1 CPSF1 LAMA5 RCN3 SAMD4A PPP2R5D MAPK1IP1L up
## LI_DCP2_BOUND_MRNA 0.0015924 0.0104291 0.7137646 2.931121 0 78 DUS1L EEF1D APEH MTX1 NDUFS8 TRIB3 APRT FAM50A CYC1 ENO1 SRRM2 MRPL12 POLR2L DEAF1 MRTO4 SPEN NDUFB7 EDF1 DCXR NOP56 CHAF1A ETFB SCO2 RUVBL2 FAHD2A MAP2K2 EIF3G PSMC3 HMOX2 TACO1 CHMP2A TPR MRPL23 MRPS12 PSMC5 SAP30BP TSPAN31 BAZ1A NDUFA13 NDUFS7 UBXN6 C12orf10 FLII RPS5 CUEDC2 PITRM1 NARF PI4KAP1 WDR74 RPSA MRPS11 TST UFC1 NT5DC2 TRAPPC2L PPIB UQCRC1 PDXK PHGDH up
## REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION 0.0015432 0.0104291 0.6912137 2.910155 0 86 EEF1D RPL39L EEF1A2 RPL38 RPS2 RPS21 RPL36 RPL37 RPL11 RPL8 RPL13 RPLP1 RPL12 RPL36AL RPL35 RPS3 RPL37A RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 FAU RPS29 RPL3 RPS11 EEF2 RPS12 RPL14 RPS14 RPL13A RPS10 RPL26L1 RPL29 RPL32 RPS24 RPL26 RPS7 RPL35A RPL9 RPS6 RPL23A RPS4X UBA52 RPL23 RPS15A RPS27A RPS26 RPS8 EEF1B2 RPL34 RPL22L1 RPL4 RPS23 RPL7 up
## HOLLERN_EMT_BREAST_TUMOR_DN 0.0015432 0.0104291 0.6609119 2.907134 0 114 RAB25 BSPRY STAP2 ELMO3 PKP3 SPINT1 SPTBN2 EVPL ST14 TMPRSS13 EPCAM LSR EPHA1 ARHGEF16 TMEM184A AP1M2 KLC3 TMEM54 STARD10 CRB3 ESRP2 TMEM30B WWC1 CLDN7 HIP1R TFAP2C PRSS8 OVOL1 GRHL1 CEACAM1 CBLC EPS8L2 EFNA3 TNK1 MAP7 TMPRSS2 CDH1 CDH3 SPINT2 LLGL2 ILDR1 PTPRF RNF43 TMEM79 TJP3 GRB7 ERBB3 GRHL2 ESRP1 MAL2 CCDC120 OCLN C1orf210 EPS8L1 MARVELD2 C1orf56 KCNK1 JUP MYO5B CKMT1A IRF6 SHROOM3 LRBA PLEKHG6 MYH14 CELSR2 IL17RE up
## REACTOME_INFLUENZA_INFECTION 0.0015083 0.0104291 0.6400575 2.895435 0 145 ISG15 POLR2J RPL39L POLR2L POLR2H CPSF4 GTF2F1 NUP205 CLTA POLR2E RPL38 RPS2 AAAS RPS21 KPNA7 RPL36 NUP210 RPL37 NUP107 TPR RPL11 RPL8 POLR2F RPL13 RPLP1 RPL12 RPL36AL RPL35 NUP93 RPS3 RPL37A POLR2A NUP85 PABPN1 RPS5 NUP62 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 POLR2D RPL28 RPL39 RPL41 CALR RPL22 RPS20 RPL18 GRSF1 RPL31 RPL18A RPL30 RPSA RPS28 FAU RPS29 RPL3 RPS11 NUP188 RPS12 SEC13 RPL14 RPS14 RPL13A KPNB1 POLR2I RPS10 RPL26L1 RPL29 NUP214 RPL32 RPS24 RPL26 POM121C NUP133 RPS7 RPL35A RPL9 RPS6 RAE1 RPL23A NUP88 RPS4X UBA52 RPL23 NUP155 POLR2C RPS15A RPS27A RPS26 RPS8 up
## REACTOME_NONSENSE_MEDIATED_DECAY_NMD 0.0015221 0.0104291 0.6552341 2.877232 0 108 SMG5 RNPS1 RPL39L EIF4G1 UPF1 RPL38 RPS2 RPS21 RPL36 RPL37 GSPT1 UPF3B SMG7 RPL11 RPL8 RPL13 RPLP1 RPL12 RPL36AL RPL35 RPS3 RPL37A RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A PABPC1 RPLP2 RPL27A RPL19 RPS16 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 FAU SMG8 RPS29 RPL3 RPS11 RPS12 RPL14 RPS14 RPL13A RPS10 RPL26L1 RPL29 RPL32 PPP2R1A RPS24 RPL26 SMG1 RPS7 RPL35A RPL9 RPS6 RPL23A RPS4X UBA52 SMG9 RPL23 MAGOH RPS15A RPS27A RPS26 RPS8 RPL34 RPL22L1 NCBP2 RPL4 RPS23 RPL7 EIF4A3 up
## REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY 0.0015625 0.0104291 0.6689549 2.869707 0 94 TRIB3 RPL39L ASNS RPL38 RPS2 RPS21 RPL36 RPL37 DDIT3 RPL11 RPL8 RPL13 RPLP1 RPL12 RPL36AL RPL35 RPS3 RPL37A RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 FAU RPS29 RPL3 RPS11 RPS12 RPL14 RPS14 RPL13A RPS10 RPL26L1 RPL29 EIF2AK4 RPL32 RPS24 RPL26 RPS7 RPL35A RPL9 RPS6 RPL23A RPS4X CEBPB UBA52 RPL23 RPS15A RPS27A RPS26 RPS8 ATF4 RPL34 RPL22L1 EIF2S2 RPL4 RPS23 RPL7 up
## ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 0.0015337 0.0104291 0.6412763 2.869694 0 130 DPP3 MAPK13 MRPS15 HMGA1 TK1 LSM4 FEN1 UBE2C PAQR4 LRP8 E2F1 CCNF PAFAH1B3 DTYMK CHAF1B ATAD2 MYBL2 MCM4 ASF1B TACC3 ACACA APOBEC3B MCM2 CDCA8 PLK1 ZWINT UBE2S TMSB10 BIRC5 FOXM1 SLC25A15 RRM2 MCM10 CDKN2A KIF4A SAC3D1 MKI67 KIF20A STIL CDC20 TPX2 HJURP RPA3 CENPM AURKA KIF2C CCNB1 PTTG1 KIF18B EIF4EBP1 AURKB NEK2 BUB1 DNMT3B CDC6 ESPL1 SPDL1 GINS4 BUB1B EZH2 BRCA1 DHFR CENPF MELK POLA2 PCNA LMNB1 HMMR NETO2 TYMS GMNN CEP55 CENPE CELSR3 CHEK1 SMC4 KIF23 DLGAP5 POLQ CKS2 NCAPH NDC80 GINS1 KIF14 CCNE2 CENPA TPGS2 SHCBP1 TOP2A PRC1 DBF4 NUSAP1 DNA2 KIF15 ASPM DSG2 GTSE1 ECT2 TRIP13 CDK1 SPAG5 CCNA2 up
## NIKOLSKY_BREAST_CANCER_1Q21_AMPLICON 0.0017036 0.0104291 0.8312773 2.864790 0 33 ZBTB7B FLAD1 EFNA4 PYGO2 DCST2 SLC50A1 PMVK MTX1 ADAM15 TDRKH FDPS DCST1 EFNA3 KRTCAP2 RUSC1 RORC MRPL9 MUC1 PBXIP1 DPM3 EFNA1 GBA OAZ3 THBS3 RUSC1-AS1 THEM5 TRIM46 SHC1 up
## REACTOME_EUKARYOTIC_TRANSLATION_INITIATION 0.0015267 0.0104291 0.6494993 2.862836 0 112 EIF3B EIF3C EIF2B5 RPL39L EIF4G1 EIF3I EIF3G EIF2B4 RPL38 RPS2 RPS21 RPL36 RPL37 RPL11 RPL8 RPL13 RPLP1 RPL12 RPL36AL RPL35 EIF5B RPS3 RPL37A RPS5 RPS15 RPL24 RPS27 RPLP0 EIF3D RPL27 RPL10A PABPC1 RPLP2 RPL27A RPL19 RPS16 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 FAU RPS29 RPL3 EIF3A RPS11 RPS12 EIF4EBP1 RPL14 RPS14 RPL13A RPS10 RPL26L1 RPL29 RPL32 RPS24 RPL26 EIF3H RPS7 RPL35A RPL9 EIF2B3 RPS6 RPL23A RPS4X UBA52 RPL23 RPS15A RPS27A RPS26 RPS8 EIF3K RPL34 RPL22L1 EIF2S2 EIF2B2 RPL4 RPS23 RPL7 EIF2B1 up
## REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0015221 0.0104291 0.6550690 2.854468 0 104 RPL39L SEC61G RPL38 RPS2 RPS21 RPL36 RPL37 SRP68 RPL11 RPL8 DDOST RPL13 RPLP1 RPL12 RPL36AL RPL35 SRPRB RPS3 SSR2 RPL37A RPS5 SEC61A1 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 SRP54 RPN2 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 FAU RPS29 RPL3 RPS11 RPS12 RPL14 RPS14 RPL13A RPS10 RPL26L1 RPL29 RPL32 RPS24 RPN1 RPL26 RPS7 RPL35A RPL9 RPS6 RPL23A RPS4X UBA52 SEC11C RPL23 RPS15A RPS27A RPS26 RPS8 TRAM1 RPL34 RPL22L1 RPL4 RPS23 RPL7 up
fgsea_plot(fgsea_res$res_c3, pathways_title='C3 regulatory target genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## FXR1_TARGET_GENES 0.0011299 0.0084544 0.5617872 3.020038 0 1002 SNRNP25 ZNF692 DNAJA3 ABCB9 HOOK2 EFNA4 ASPHD1 NOP9 PYGO2 INPPL1 C16orf91 RNF40 ZNF623 RER1 PUSL1 POLR3K NOL3 OGFOD3 ELMO3 SLC25A22 DDX56 PIGQ ATAD3B PRR7 SHARPIN ZBTB45 WDR55 METRN C1orf61 SLC50A1 KCNC3 WDR4 ZNF696 KIF16B PEX10 PIGO AIFM1 B4GALT7 MTX1 SRCAP CAPN15 JMJD4 MRPS26 NPLOC4 MVP RECQL4 SIPA1L3 RCC1 KCTD5 ZNF764 TSR3 USF1 TYSND1 KIAA1522 PFDN2 MFSD3 RHOT2 LRRC14 TSTD1 ZBTB42 DHCR7 NECAB3 CHD8 FKBP2 TRIP6 CHMP6 LSR SRM FAM50A TAF4 ZNF213 CCND1 FBRS AARS2 MAD1L1 ATXN2L ZC3H3 TSEN54 CAPN12 SNORA14B FRMD5 RPTOR DBNL NOP2 CYC1 TPRN PDAP1 ZNF462 HAGH ZGPAT MRPL12 SNAP47 TRAPPC9 DNAJC11 NELFA ZNF768 DDRGK1 FEM1A SEZ6L2 SEC24C SUMF2 PKMYT1 NADSYN1 ASB16 NOM1 ENTPD6 MRPL28 MPI MNT HAX1 CORO1B NUMA1 PPFIA3 DEAF1 SMURF1 STUB1 GNPTG AGK SRRT MFSD10 UBE2C ZNF3 ACADVL ANKZF1 LSM14B FAAH PGBD2 ALG1 PAQR4 UBTF SART1 CXorf56 KRTCAP3 GRWD1 F11R PPP1R37 ATXN7L3 HMBS CLDN7 SUSD4 CHCHD1 PCYT2 TRMT61A MLPH CYHR1 DAGLA TBX6 GEMIN4 TRABD SLC35B1 SESN2 EML2 AMH ARX BPNT1 EXOSC6 C1orf109 GRHL1 DHPS RREB1 TSFM ARFGAP1 PLEKHA8 AVIL UBE3C IRF7 TNPO2 TMEM201 DDX55 PHPT1 KMT2D CCNF C9orf163 HNRNPAB NMT1 CMTR1 IMPDH1 POLD1 PPP4C MRPL11 HMGXB3 FAHD1 EPN1 ERCC2 NOLC1 VPS4A XYLT2 CRTC2 ALDOA MUC1 ARFRP1 SIGIRR MRPL21 SLC35B2 ARID1A CD55 EIF3G TRMT112 RPUSD4 PPIL2 ADAT1 SNRPE KPTN B3GNT8 RABIF PPP6R1 PTOV1 DPH7 MSTO2P SSNA1 FTSJ3 LAMTOR1 UNC45A ABCA7 PHF12 PACS2 APEX1 GMEB2 ACIN1 LIF TIMM13 CLK3 PRDX5 ZMAT2 ZNF839 WDR73 TACO1 IGHMBP2 RNU5A-1 AMDHD2 LRIG3 SS18L1 RPL36 PNKP LSM5 NKAP LTBP3 CHMP2A DHRS1 SNAPC5 ZC3H4 HMGB3P22 PA2G4 PSMB4 SRRM5 DDIT3 PRKCA SNX19 B4GALT2 LINC00630 NAB2 MIS18A GTPBP4 METTL2B MFSD9 DPM2 FBXW5 IL17RC MAZ PLK1 PCED1A ANAPC2 FBXW9 TJP3 SYTL1 ZNF513 POMT2 CWC25 NEIL1 C1QBP PSMA7 TOR4A SYT7 TAF12 HSD11B1L PCK2 ATG9A TRNAU1AP GBA TAOK2 MPV17 KAZALD1 PTDSS2 SLX4IP RPL13 C8G CSRNP2 SLBP CYTH2 CIC DHRS13 TMEM147 WDR83 PSMC5 CASP2 SPRED2 RPL36AL SYMPK PAIP1 CORO2A NOL12 IARS2 ELL3 COG7 MAP3K11 THBS3 MORN1 PRDM15 VPS16 TRIM65 ANKRD54 AC007389.1 NOP14-AS1 USP19 HYI RBM28 ZNF579 RNASEH2A PAQR6 NDUFV3 CUL9 TOP3B TALDO1 POMZP3 RBM42 KLHDC2 FOXM1 SNRPC RRP7A SLC25A15 PLCH1 SGSM3 MLX AAR2 MRPL38 ANKRD13D C12orf10 POLR2A MRPL3 SLC1A5 MARVELD2 TCIRG1 RAI14 CREB3L4 CD151 NUP85 HDDC3 C1GALT1 HIRA CDK11A DMKN BCRP8 LZTR1 PTOV1-AS1 THAP3 RTN4RL2 LANCL2 CDYL RPS5 SPAG4 GTF3C5 CASP6 PPP1R13L DRG2 PAM INO80E EHMT1 TMEM182 TXN2 SAC3D1 TMEM179B SF3A3 CTSA TRIM47 TSPAN10 RRP36 NAGPA PIGM MAMSTR KANSL3 CALR MXD3 STRN4 MAF1 ZNF544 DTD1 ZFAND2B ZNF609 SCYL3 GSK3A MED29 PRKAR1B MRPS11 MORC2-AS1 PMF1 SAE1 STX6 ADCY9 RAB27A FAM131A NFIC SMG8 CNIH4 RPS29 NDUFC1 GTF2H2C DBP SMARCD2 HJURP MRPL10 TAF10 ZNF77 ALDOC CNIH2 DNAH2 XRRA1 ATP2A1 FKRP FAM193B CTNS GPI GTF2A2 DNMT3A PHLDB3 LRRC73 ZFAS1 SEC13 FAM200A DENND6B GLCCI1 ZNF653 SH3GL1 C8orf33 HUWE1 DPCD AP2A2 NSFL1C CASZ1 TOMM20 SLC4A11 MED26 MRPS27 ARFGEF2 FAM118B TULP4 IKBKE CDC6 TIGD6 POLR2J4 WDHD1 MIRLET7I XXYLT1 CRELD1 NUP210L RIN1 COMT CDR2 CYBA ZSWIM8 PLXNB1 AKAP8 VRK3 PMM1 ELK1 ARHGDIA IRGQ UNC119 UCK1 CDKN2AIPNL RRP15 CXorf38 UBC INTS4 SUSD2 PLS1 MLLT3 MTFR1L CITED1 POM121C NDUFA4 LARS2 SIX5 RPS7 SLC35E3 WDR81 CCAR2 PARP12 COX8A ACCS RALGDS RHOF PIP4K2B SLC35A3 TBC1D10A RBM23 OSGIN1 POLDIP3 UHMK1 SGMS1 GMPPB RPS6 RAE1 RTBDN SIPA1 UBL4A DBNDD2 up
## SUPT20H_TARGET_GENES 0.0011136 0.0084544 0.5473829 2.963475 0 1169 SSU72 FLAD1 RRNAD1 MLST8 DNAJA3 ABCB9 CLPTM1L TBL3 RCE1 MST1P2 COASY MRPL55 MRPL24 C16orf91 WDR24 PRPF6 GTPBP3 C7orf50 DDX56 AURKAIP1 FBXL19 ATAD3B EEF1D SHARPIN PDCD6 ZBTB45 UBE2I MRPL4 TARS2 DHDDS LGALS3BP ABCB8 FAM207A ADAR WDR4 RAB40C NUBP2 E2F4 MRPL20 B4GALT7 TRMT1 ZNF687 JMJD4 AK2 FOXRED1 RECQL4 LONP1 BMS1 KCTD5 TSR3 ZNHIT1 ZNF646 RFXANK DDX23 ABCF2 LRRC14 ISG20L2 TMEM222 HDGF CCDC86 GCDH GTPBP2 NOC4L TIGD5 TBC1D10B DDX41 FAM220A ZC3H3 EVI5L PRCC FRMD5 RPTOR TRMT2A SMPD4 STIP1 NOP14 EXOSC5 MAFK PRMT5 BECN1 RPUSD2 FAM71E1 HAGH ZNF12 LMAN2 YIPF2 SNAP47 GOLGA3 PMS2CL DNAJC11 FEM1A C12orf76 MZT2B MTOR CLPB MRPL28 ACOT8 DDX51 TRUB2 HAX1 ERAL1 CROCCP2 LRCH4 MYPOP VPS9D1 ABCF3 RANBP1 LAS1L PIGG SLC39A3 GNPTG CTU2 IPO4 SCNM1 SLC27A5 PRMT7 ENSA PAGR1 EMC10 ALG1 RECQL5 HPS4 NFATC2IP MRTO4 RNF121 ZSWIM3 MTND5P11 FDPS TMEM208 CEP250 NSUN2 LSM7 SLC35B1 TRMT44 DDX42 NCAPH2 NAT10 TRAF2 RPS6KB2 TCF3 SLC35E1 TMEM101 RUVBL1 C1orf109 RAD23A HSPA5 TSFM NVL PSMC4 AP5Z1 NDOR1 ISOC2 CCDC159 INTS5 DDX55 USP42 TMEM63C KMT2D CCDC130 MIR4479 POLR3E NPM3 SPG7 PRRG2 DPP9 RAB11B KRTCAP2 TMEM9 ADPRHL2 PTPN23 UTP3 PLOD3 NMT1 PRMT1 XAB2 CDK5RAP1 TOMM40 HMGXB3 FAHD1 DAGLB KHSRP ARMC6 ZNF263 MT-TP CRTC2 MRPL9 CACTIN FBXL19-AS1 NDUFAB1 MRPL21 TTC31 TMEM259 NGDN MRPL49 LMF2 PSMC3 EIF2B4 DDX19A ILF3 PPP6R1 SSNA1 ZNF408 FAM222B TPCN1 POLE UNC45A PHF12 INO80B MAP2K7 DNAJC21 PPRC1 SLC4A1AP ACAD9 CCDC47 RBBP5 AAAS DCTPP1 ZMAT2 CDK12 EFTUD2 TACO1 WDR53 IGHMBP2 MT-RNR1 MPHOSPH10 MT-ND1 EIF1AD SPPL2B THAP7 RPL36 LSM5 USP54 IDH3B CHCHD3 HMGB3P22 RPL37 SRRM5 NUP107 PIGT GAR1 COPS7B MIS18A GTPBP4 MNAT1 VPS51 TMEM203 ILF2 ANKRD16 CDCA8 RN7SL1 RHBDD3 SMG7 PHF14 PAK1IP1 GPR108 ANAPC2 FBXW9 NFKBIB GTPBP10 DCTN5 CXXC1 RELA ACSF3 CWC25 DNAJC2 PREB MED9 HSPD1 CHMP4B RNU5E-1 NBR2 NDUFS3 MED18 PSME3 MVD MCRS1 HNRNPA1 ADPRHL1 BANF1 CCDC106 CCDC142 OAZ3 ZNF26 XRCC2 MAD2L1BP MPV17L2 ZNF830 MRPS23 MTHFSD MRPL48 LSG1 CYTH2 STOML2 CIC CYB561D2 RPRD2 WDR83 AARSD1 EMC1 SLC7A6OS RPL12 GATAD2A POMGNT1 DDX49 NOL12 ZC3HC1 RPIA SAP30BP ZBTB17 MAP3K11 C1orf74 PWWP2A HNRNPUL1 USP19 TSPAN31 AKAP8L EXOC8 RBM28 NDUFV3 TOP3B MRS2 ZNF276 TRAPPC6A RBM42 LRRC27 DHX38 NME1 NDUFS7 EEFSEC NME1-NME2 FAF1 PET100 MRPL2 SNRPC TSKU DUS2 UBXN6 LYSMD1 COQ4 COQ9 AAR2 RTEL1 FBXO24 CHCHD4 POLR2A DCAF15 TUT1 RFX1 MRPL3 NPRL2 RNU6-418P TMEM41A APTX RNF167 SPAG7 ACO2 LRSAM1 TCERG1 VPS25 HIRA TRIP4 NAIF1 SAYSD1 PDE4A CDK11A KCTD2 TNPO3 PABPN1 TMEM141 GTF3C5 COPE RPL24 NF2 PPP1R13L TRIM46 DRG2 RAB11B-AS1 SSBP1 EHMT1 TXN2 STX4 ZNF668 DCAF11 TOMM22 RPLP2 MUL1 TTC1 PEX13 TMEM205 SF3A3 PSMC2 PDRG1 ARID3A TMEM183A ALKBH7 SCFD2 ATP13A4 NR1H2 PTCD1 DPF2 ANKRD11 AHCYL2 TMEM209 PSMF1 NAGPA PHLPP1 MED24 NOSIP RBAK MAN2C1 JUP MAF1 PALB2 CREBBP SUGP2 BLOC1S3 ZNF581 WNK1 RPL18 RPL31 WDR74 SP2 TIMM9 RNU5B-1 CIAPIN1 DHX33 ARHGAP1 RBM15 SLC35A4 PXMP2 RPS28 NFIC GBF1 SH3YL1 FAU SMG8 RPS29 TMEM160 UQCC1 PHF5A GPATCH3 SMG7-AS1 ZNF77 CNPY2 RAB3D YEATS4 RPS11 AHSA1 DNAJB12 KATNB1 RBM19 NOL9 BYSL GPI SLC25A11 SPSB3 TSSC4 CHRNB1 ZFAS1 SEC13 CCDC12 RAD9A ZNF580 C8orf33 APBB3 SRSF1 MRPS17 BOD1 SIVA1 C17orf75 TWISTNB STK32C BRIX1 MT-TF MMACHC SPC24 TIGD6 STT3A SF3B5 DNAJB11 C11orf49 TIMM17A MVK POLG AGBL5 PUF60 PEF1 DCAKD CCDC58 ZNF131 ZNF165 NUDT5 NFE2L1 IRGQ CCNK CTNNA1 KLHL20 CCDC97 SPHK2 NUP214 B4GALT5 CD3EAP AP2A1 RALGAPA1 U2AF1L4 RRP15 SLC2A11 CXorf38 SMARCD3 BUB1B PPP2R1A NFX1 SYNGR4 SPRTN BRCA1 CDC5L ZNFX1 LRPPRC VCP POM121C BPGM SNX12 POLA2 BAP1 SFSWAP PRPF18 SAFB ANKFY1 RPS7 CHTOP CENPL RFX2 NDUFA2 NUDT18 CCT4 CCAR2 CHMP4A COPB2 TMEM115 RPL9 FBXO45 STRIP1 C12orf43 ZNF79 RBM23 POLDIP3 STX16 RPS6 FARS2 SAR1B RPL23A UBLCP1 MED20 RNU6-2 SLC33A1 PDCD7 CKLF-CMTM1 COPZ1 FAM162A NAA38 HNRNPA0 TRMT61B CPSF1 GLOD4 TMEM143 THAP7-AS1 ENPP3 WDR43 RPL23 MRPL44 HOXC5 NR1H3 CELF3 TSN NIF3L1 ACOX3 ZMPSTE24 MAGOH SUPT7L NUP155 PROSER1 EIF2D ARHGEF2 RPS26 LRRC29 STX18 TPI1P2 NUBPL XRCC3 WDR70 MKS1 IK MOCS3 FAM117A PXMP4 SMC4 TRIP10 NOP16 BCKDHA BANP HNRNPL FAM185A NMNAT1 SREBF2 RTEL1-TNFRSF6B CANX up
## EPC1_TARGET_GENES 0.0012937 0.0084544 0.5886085 2.923796 0 332 SLC4A2 SSU72 CLUH MST1P2 ISG15 AIMP2 ZBTB45 REPIN1 MRPL4 ESRRA INTS1 POLR2J ALG3 ZNHIT1 PMS2 CRELD2 LARP1 GUSB GFER CCDC86 NOC4L GALE RNPS1 HRAS RNF44 ECE2 HMGA1 TRMT2A NELFCD DECR2 PDAP1 ADRM1 HAGH ZGPAT SETD1A THAP4 TMEM63B MRPL14 DHX37 DDX51 CROCCP2 RANBP1 SCNM1 LSM14B AP4M1 RABGGTA NCL DDX42 NOP56 TSFM DUS3L GSE1 FBXO41 B3GALNT2 PTBP1 ZP3 HES4 PUS1 PLOD3 TXNL4A FLVCR1 PRMT1 FAHD1 ASNS PKM KLF16 CCDC57 WDR5 C12orf66 ARFRP1 CNOT11 PGM2L1 SNHG7 DIAPH1 CCDC47 MCM7 TIMM13 U2AF2 ZNF839 CAD EIF1AD POFUT2 DNPH1 CAMTA2 CCT2 COA6 MAZ LRRC59 F12 RAD23B GBA BANF1 CCDC106 MALAT1 UBE2S SLBP ZKSCAN2 TMEM248 SPRYD4 VEGFA MGME1 MMP15 HNRNPUL1 URB2 XPOT GRK6 YTHDF2 EMC8 G6PC3 EIF5A MRPS35 NME1 NME1-NME2 NDUFA11 DUS2 LYSMD1 COX4I1 TRPC4AP ATG4B MRPL3 MKRN3 VMAC RPL10A PABPC1 STAG3L3 ZNF581 SNRNP35 PPAT SLC3A2 BUD31 RPSA TAF5L TOB2 GOT2 C16orf70 ANP32A SFXN4 SCAP SURF4 RNF145 ZNF775 ALG12 MDN1 BYSL RTCB PINX1 CD63 ZNF580 HNRNPF AURKB PTMA KPNB1 CCDC169 LRRC56 SF1 MTG1 MVK ARHGDIA METAP1D FZD5 EZH2 MRPL15 RPL26 PIEZO1 SCAMP5 SNX12 IZUMO4 PDXK ESF1 SLC25A51 CCT4 RPL35A GNAS-AS1 RALGDS CCNB1IP1 SPRED1 RPL23A MED20 SNX5 UBA52 WDR43 ANP32B ANPEP up
## THAP1_TARGET_GENES 0.0010730 0.0084544 0.5264218 2.893357 0 1667 TBRG4 RHPN1 NUDCD3 SSU72 RRNAD1 DNAJA3 MRPS34 CLPTM1L TYW1 TBL3 HOOK2 PYGO2 MST1P2 COASY MRPL55 SAMD10 DUS1L RPUSD1 C16orf91 TOP1MT C1orf35 NMRAL1 NOXA1 PRPF6 TSPAN17 DNTTIP1 PYCR2 SMG5 GTPBP3 ISG15 C7orf50 ATAD3A FADD AURKAIP1 FAM86C1 JMJD8 B3GALT6 RBCK1 CD2BP2 SHARPIN CCDC137 SMARCA4 ZBTB45 MTG2 MRPL4 PKP3 TRPT1 GDPGP1 DHDDS PGP REEP6 GTF3C2 RHPN1-AS1 WDR90 NUDT22 PEX16 RAB40C NUBP2 WFDC3 E2F4 PDF PEX10 MRPL20 AIFM1 B4GALT7 QTRT1 MTX1 ECI1 YTHDF1 ZNF212 DIDO1 JMJD4 NPLOC4 NDUFS6 PABPC1L SIPA1L3 LONP1 LRRC47 KCTD5 ZNF764 MRPS2 SH2B1 TSR3 USF1 ZNHIT1 NCLN E4F1 CHTF18 RFXANK IWS1 DDX23 ABCC3 MRPS15 P4HB CRELD2 RHOT2 WDR18 NUDC GID8 MPG GUSB TUFM ISG20L2 TMEM222 TM9SF4 USP21 GON4L CCDC86 TRIM41 ZNF398 EME2 POLRMT NDUFV1 NOC4L SNHG12 THEM6 C1orf174 GDF15 RRP9 UBE2Q1 STX10 SH3BP5L ZNF213 OXLD1 DDX41 FBRS AARS2 RPL39L CANT1 CIB1 EVI5L ARHGEF16 RPTOR TRMT2A SMPD4 NPRL3 ANAPC11 TUBG1 CLCN7 PRMT5 SQSTM1 AUP1 BECN1 ATG16L1 KDM5B KRTAP5-AS1 ZGPAT LMTK3 LMAN2 SNAP47 MZT2B SNX18 PCSK4 PDXP B4GALT3 ACTR3B MFN2 TMEM175 ZNF341 DDX51 CCNL2 EIF4G1 TRUB2 NPHP4 CROCCP2 VPS9D1 RANBP1 TMEM129 PRSS27 PIGG GNPTG FN3KRP CTU2 SLC27A5 GPR137 ENSA HARS2 PITPNM1 ZNF3 SDF4 AP4M1 CCDC124 ALG1 RECQL5 STK40 YKT6 HPS4 WDR34 MST1 URB1 ALYREF GUK1 NCDN GPX4 GCC1 EDF1 CEP250 OS9 NSUN2 DDX27 TRMT12 TRMT44 NCAPH2 NAT10 TRAF2 LMF1 UMPS CHCHD2 EXOSC6 TMEM101 DUSP8 RUVBL1 BAD PARP3 ZNF785 RAD23A TUBGCP6 RPS19BP1 FPGS PSAT1 PSMC4 AP5Z1 MAN1B1 NDOR1 ROMO1 PRR14 MZT2A PTBP1 DDX55 TP53 USP42 MED16 UBE2M CDK11B CCDC130 MIR4479 SNX8 IMP4 POLR3E CPSF4 TMEM9 ADPRHL2 TRMU CTNNB1 PTPN23 LINC00853 FAM86EP PLOD3 LAMTOR4 RAB11FIP4 ZNF778 TXNL4A NELFB ADK HOXC13 GBAP1 TLE6 STXBP2 POLD1 XAB2 CDK5RAP1 TOMM40 HMGXB3 ABCC10 NDUFS2 ASNS DNMT1 EPN1 ZNF746 CHERP NOLC1 RUSC1 PPP1R8 CCDC57 B3GAT3 PSKH1 POLR1A CACTIN SLC35E2B COX19 ARFRP1 TMEM53 MRPL21 ATP11A MAP2K2 SLC35B2 TTC31 TMEM259 LMF2 NEURL4 CTU1 RPUSD4 PGLS PSMC3 PPIA KPTN PLAGL2 SGTA DDX19A ILF3 PPP6R1 HMOX2 MCAT PSMA6 PTOV1 SNHG7 DPH7 CD46 MRPL36 CCT7 SAMD4B COPS6 DIAPH1 SIRT6 PSMB5 PSMA5 SNHG9 C9orf16 PIAS4 PHF12 SRD5A3-AS1 FAM86C2P RRP1B CHCHD5 RPS2 TBC1D22B ZNF514 ASF1B MCM7 ENDOV OTUD3 ZNF384 TACC3 PRDX5 ZMAT2 PTPRU ZNF839 DROSHA EFTUD2 CAD WDR53 IGHMBP2 AMDHD2 MPDU1 RPL36 ARFIP2 LTBP3 SNAPC5 UBAP1 COG1 DPP7 ADAMTSL5 METTL3 PA2G4 MARK4 FAM13A GGA1 DLX4 TARBP2 DNPH1 FIZ1 MIS18A WAC-AS1 ALG8 SMKR1 TMEM79 SLC27A4 VPS51 TMEM203 ILF2 ZXDC TPD52L2 TAX1BP1 PCED1A ZDHHC5 NFKBIB CUL7 SRP68 BAK1 ACSF3 ZNF425 PREB SRA1 KRBA1 CCDC9 BAX CHMP4B MAPK8IP3 TTPAL TOMM40L EXOSC2 WWP2 HSD11B1L TMEM219 NDUFS3 ZNF787 LINC00881 MED18 AGFG2 ZC3H18 PSME3 GBA TAOK2 MSANTD4 MVD DNPEP RCOR2 MLEC TPGS1 PTDSS2 CCDC142 SLX4IP CSNK1G2 HSPBP1 IRF2BP1 MRPS23 MTHFSD ZNF688 CIC ADCK1 DHRS13 ZKSCAN2 TAPT1-AS1 RAD50 TTLL11 RPL12 TRAFD1 CNPPD1 SPRYD4 RCCD1 HK1 MGME1 SLC5A6 ACY1 SAP30BP LINC00337 OGDH ZBTB17 THBS3 EPS15L1 C1orf74 VPS16 TMED1 POLR1B IMP3 HNRNPUL1 RNF123 WDR60 URB2 SEC23B XPOT ZNF579 TOP3B RBFA YIF1A DEF8 COX6B1 G6PC3 ZNF276 NAPA EIF5A SNRNP70 KIAA0319L DHX38 RIC8A GRHPR EEFSEC FAF1 CS PET100 MTHFR NDUFB9 PPP1R12C DCTN1 SNRPC SLC37A3 CSAD PDCL3 TOM1 COQ4 COQ9 PIN1 RFX1 CYP51A1 TBC1D14 ZNF584 ACO2 MKRN3 LRSAM1 SZRD1 HIRA NAIF1 CDK11A LRRCC1 PTOV1-AS1 TECPR1 THAP3 PABPN1 LANCL2 VGF RPS5 PGAP2 GORAB USE1 MCM10 EIF3D AKIRIN1 SDHAF1 ZSCAN31 RPL27 SHC1 AKT1S1 PPARD ZNF497 VKORC1 CUEDC2 RPLP2 SCLY UVSSA RPL27A DGUOK PTPN18 MFSD5 ZNF689 ATP13A4 PTCD1 PROB1 DPF2 CTSA TSPAN10 PTRHD1 SSR4P1 RRP36 DNAJC14 GALNS NAGPA STOML1 PHLPP1 ECH1 RPL39 GGNBP1 MAN2C1 MAF1 FASTKD5 ZSCAN20 RPS20 PPP2R5E UBOX5 ZNF581 SNRNP35 RPL18 MFAP1 DHODH RPL18A WDR74 UBAP2 SCYL3 SP2 DNAH14 MZF1 KCTD21-AS1 AGTRAP GNA12 SRD5A1 FAM86DP TAF5L CIAPIN1 ZBTB11-AS1 AKT2 AIMP1 SLC38A7 SLC35A4 TM9SF1 ANKRD24 PARS2 EP400 SH3YL1 DDX39A TMEM160 DSN1 UQCC1 FAM83G DBP NFS1 PHF5A IGLV3-21 VPS13D C16orf70 RPA3 ANP32A IFT140 RSF1 DNAL4 ORC1 AHCYL1 MED15 HUS1 CNIH2 RPS11 AURKA KIF2C APMAP KATNB1 OSBP GAK MBD1 MBD3 ALG12 RPS12 FAM193B ICMT MDN1 ZNF524 CTNS SMARCC1 CRKL GBA2 CCNB1 DVL2 MON1B UFC1 OXA1L CYP4A22-AS1 HPS1 SPSB3 SEC13 SYT5 RTN4R MIR210HG ABCA17P AP1B1 RAD9A MEA1 TFIP11 RNU6-9 APBB3 NIPAL3 BOD1 DPAGT1 SIVA1 C2CD2L C17orf75 RPS14 MTMR4 NOA1 ACLY MED26 LHPP BRIX1 ARFGEF2 FAM118B TULP4 MTX2 IQCC ZNF747 WDR3 TIGD6 ZC3H11B PRKAB1 SF3B5 SUPT3H DNAJB11 SNRPD3 CDC42SE1 MIRLET7I UBXN1 FRS2 BOK-AS1 LGALS8 ERI2 TRAPPC2L TAZ ZSWIM8 UBTD1 POLG AGBL5 KPNA6 FIBCD1 LRRC37A3 PEF1 CNPY3 VRK3 CSK NUDT5 MSRB2 RPL26L1 ZBTB7A PRDX6 NFE2L1 EML4 MADCAM1 SPHK2 NUP214 RPL32 MIR4258 BTF3 AP2A1 RN7SL521P ATP6V0D1 METTL17 UBC GUCD1 PPP2R1A LASP1 MTCH1 USP40 HSF2BP HMGCL YARS2 MORN4 SYNGR4 SNAPC2 TGS1 AIP MIR320A ABHD12 CATSPERG COPS7A BAP1 ETV3 EIF3H TRMT5 HSPA8 PTCD3 HSDL1 KAT5 UBAC2-AS1 TMEM198B CFDP1 PSMD8 RPS7 ANKRD13A ZNF252P FTH1 CENPL RNASEH2C CSTF1 LINC00115 CCT4 CTCF RANBP3 WDR81 CCAR2 POLR1D ATG4A FBXO45 ARHGAP12 WRAP53 MBOAT7 ZNF79 CLSTN1 POLDIP3 SGMS1 GMPPB STX16 ATR LYAR TADA3 RAE1 LINC00649 SAR1B ZBTB40 CLCN6 LNX2 ZBTB8OS RNU6-2 DEPTOR SLC33A1 CKLF-CMTM1 TRMT61B PIGV CPSF1 COCH TMEM143 DGKZ SNX5 UBA52 ENPP3 SLC9A1 WDR43 CITED2 GTF3C6 MAPK1IP1L TMEM144 C5orf63 MRPL44 IPPK EXD3 RPA1 CELF3 CELSR3 TBC1D17 up
## CEBPZ_TARGET_GENES 0.0011099 0.0084544 0.5284596 2.877859 0 1304 RHPN1 SNRNP25 FLAD1 MLST8 TYW1 TBL3 MST1P2 ARHGEF19 DPP3 WDR24 POLR3K PYCR2 OGFOD3 GTPBP3 C7orf50 AIMP2 DDX56 JMJD8 SHARPIN CCDC137 TRAF7 MRPL4 TARS2 PGP TMEM134 ZFP41 RHPN1-AS1 ABCB8 FAM207A POLM AP3D1 CEP85 PEX16 RAB40C NUBP2 POLD2 B4GALT7 MORC2 TRMT1 ZNF687 GGCT LRRC45 AK2 NPLOC4 NOL6 BMS1 LRRC47 KCTD5 NDUFS8 TSR3 BRPF3 DPH2 ZNF672 PMS2 COMTD1 MRPS15 P4HB NUDC LMTK2 ISG20L2 DHCR7 HDGF PCGF1 MROH1 PDIA4 CHD8 POLRMT SNHG12 ZDHHC9 EARS2 MAST1 DGCR8 MAP3K9 HRAS TBC1D10B COA4 ZNF213 OXLD1 DDX41 FBRS FAM220A TIMM44 EVI5L FRMD5 RPTOR ROGDI STK11 NOB1 STIP1 ENO1 TPRN DOLPP1 PDAP1 OSBPL2 ATG16L1 ADRM1 HAGH VPS72 LMAN2 EMC9 YIPF2 SNORD60 FOXK2 GOLGA3 DNAJC11 C12orf76 CDK2AP2 MTOR SNX18 THAP4 ZNF174 ARL16 PDXP NOM1 MGRN1 MIIP MRPL28 ACOT8 CCNL2 NPHP4 PACSIN2 CROCCP2 LRCH4 ZSCAN32 SLC39A3 GNPTG IPO4 SDF2L1 KIF22 GPR137 ENSA RMI2 UBE2C ANKZF1 TDRKH ALG1 RECQL5 STK40 RNF187 PNKD PSMD3 MOSPD3 NFATC2IP RRBP1 ZDHHC12 CDK5RAP3 ZSWIM3 CYHR1 OS9 TRMT44 HGS EML2 TRAF2 UMPS CHCHD2 TCF3 RUVBL1 C1orf109 RASSF7 SNAPC4 HSPA5 ARFGAP1 CHAF1A NDOR1 ISOC2 MAEA CCDC159 INTS5 PTBP1 DDX55 MED16 PHPT1 CDK11B E2F1 CCDC130 CCNF MIR4479 CPSF4 SPG7 ZSWIM1 RAB11B AAMP TMEM9 TRMU HNRNPAB LAMTOR4 RUVBL2 PRMT1 SND1 FAM98C XAB2 CDK5RAP1 FLYWCH2 TOMM40 SNRPA FAHD1 HINT2 ZNF324B MLLT1 KHSRP ERCC2 ARMC6 SPATC1L WIZ CRTC2 COX19 TMEM53 MRPL21 CIT GYS1 BAZ2A NGDN DPH1 DDA1 ARID1A PPIA SGTA MCAT PDCD11 DPH7 CCT7 SAMD4B UBFD1 SSNA1 FAM222B IKZF4 TSR1 PSMA5 TPCN1 SLC2A8 ABCA7 NABP2 RPL38 SLC4A1AP C19orf53 ASF1B ZBTB18 DCTPP1 ZMAT2 MED8 RNF4 DROSHA TACO1 WDR53 IGHMBP2 SEMA4F NXT1 MPHOSPH10 EIF1AD PNKP LSM5 ELAC2 SZT2 AMBRA1 IDH3B CHCHD3 TYK2 RPL37 NUP107 BABAM1 TARBP2 COPS7B MIS18A PAAF1 MIR4449 ZSWIM4 RGMB-AS1 SLC27A4 MYL5 VPS51 DDX19B TMEM203 FBXW5 ANKRD16 CDCA8 CTPS1 WDR6 GPR108 ANAPC2 DCTN5 MRPL37 CWC25 CCDC61 KIAA0895L HSPD1 QPCTL MAPK8IP3 NDUFS3 DDOST AGFG2 DRAP1 CIZ1 ATG9A LINC01003 CCDC51 GBA NSMCE1 MSANTD4 MVD HNRNPA1 HTT ZNF691 BANF1 INCENP TP53BP1 C8G ZNF354A MPV17L2 PNPO ZNF830 MRPS23 CYTH2 STOML2 CIC MRPS12 GATAD2A TRAFD1 PSMB10 ASB16-AS1 HMGXB4 DDX49 ZC3HC1 RPIA SAP30BP MAP3K11 ANKRD54 PWWP2A HNRNPUL1 WDR60 URB2 TSPAN31 AKAP8L RBM28 TOP3B YIF1A DEF8 GRK6 ZNF574 TRAPPC6A RBM42 LRRC27 TMUB2 DHX38 PDP2 NME1 NDUFS7 NME1-NME2 NDUFA11 PAF1 CS PET100 PPP1R12C TAF1C SNRPC HIBADH DUS2 PSMB3 ORMDL2 UBXN6 FBXO24 PSMD11 PIN1 PEX14 C12orf10 POLR2A DCAF15 ATG4B RFX1 MRPS16 MRPL3 SLC1A5 TIMM8B GTPBP1 TMEM41A TBC1D14 SPAG7 ZNF584 GATAD2B SLC39A1 CREB3L4 PDIA6 ACO2 TCERG1 CYB5B HIRA TRIP4 NAIF1 VMAC KCTD2 TECPR1 PABPN1 PGAP2 TP53TG1 BCL2L1 SHKBP1 GTF3C5 RGMB COPE RPS15 GOLGB1 RPLP0 NF2 SNRPD2 SDHAF1 ZSCAN31 RAB11B-AS1 SSBP1 TSR2 SHC1 DCAF11 ANKRD39 AKT1S1 TMEM179B TMEM205 SF3A3 NARF SNRNP40 RAB40B ALKBH7 MCU NR1H2 PTCD1 ECSIT ANKRD11 CTSA TSPAN10 DNAJC14 PSMF1 NAGPA PIGM TSPAN15 MAN2C1 JUP MAF1 RPL22 PALB2 ZSCAN20 RFWD3 TRAIP RPS20 PPP2R5E BLOC1S3 ZNF581 RAB3A LCMT1 IVD GRPEL1 TRIM68 DHODH RPL18A SP2 MZF1 RSBN1L GNA12 HOMEZ BUD31 MED29 MRPS11 TAF5L TNFRSF10B RBM15 ZNF837 PRPF8 CLUHP3 FNBP4 TRIM45 GBF1 FAN1 SMG8 APLP2 LLGL1 DDX39A TMEM160 DBP PHF5A CDIPT VPS13D FGD6 RAD54L CENPM C19orf81 GPATCH3 DNAL4 ERICH1 ZNF77 SLC35F2 RAB3D FAM120AOS AURKA APMAP TBCB KATNB1 OSBP ZNF775 MBD1 CTNS SLC52A2 BAIAP3 UBALD2 LARP4B MON1B MCM3 SPSB3 ZNF726 ZNF774 SEC13 RNFT2 SYT5 RTN4R PLIN3 GLCCI1 CCDC12 RNU6-9 C8orf33 DCBLD2 NIPAL3 SIVA1 KDM4B COX14 MTMR4 INPP5B RPL13A KPNB1 TROAP SPC24 STT3A POLR2I GLO1 GANAB COMT CDR2 MVK ITFG2 PEF1 CNPY3 AKAP8 ZNF138 HDAC11 MDM1 ZNF165 NFE2L1 FH BRIP1 KIF1B NEAT1 CCNK NUP214 SWSAP1 MED19 ZNF367 ARVCF AP2A1 VEZT CREB3L2 TBC1D22A RRP15 CA13 TTF2 DANCR INTS4 MAGI3 PPP2R1A FDFT1 MTF1 NCOA2 C14orf93 BRCA1 RAB4B MTMR12 C12orf49 CKAP2L VCP FXN BPGM SNX12 VPS28 SFSWAP FAM111B NRL ABR KCTD7 GOLPH3L MPZL1 CEP164 TMEM198B ESF1 RPS7 MTR RFX2 NDUFA2 CSTF1 DAPK3 WDR81 CCAR2 POLR1D COX8A RPL9 GOT1 RBM14 FBXO45 CDC25A EIF2B3 MCM5 STX16 ZNF100 ATR WDR12 LNX2 TMEM191C RBMX COPZ1 TRMT61B GLOD4 RPUSD3 ELMO2 ENPP3 EDEM3 CIRBP MRPL44 ALKBH6 TANGO2 SFXN5 ZNF200 ACOX3 RBM14-RBM4 ZMPSTE24 SUPT7L RPS15A CYB5A NAA60 EIF2D DCAF4 GORASP1 GNG4 STX18 RSPRY1 CETN3 PANK2 XRCC3 IK SARS2 FAM117A ZCCHC17 PXMP4 TRIP10 FBXL6 ASAP3 RHCE CEP152 HNRNPL NMNAT1 IER5L CANX HLTF TCEA1 MAPKAPK5 ATG14 DLGAP5 MANBAL SPRYD3 POMT1 POLQ SLC25A42 IFI27L1 ABHD8 ADSL HINFP TUBB4B CHD6 SAP30L-AS1 MRPL46 SNHG10 PURB NEURL2 IDH1 ZNF547 up
## KAT5_TARGET_GENES 0.0011534 0.0084544 0.5421652 2.872177 0 768 SLC4A2 ZNF692 RRNAD1 TBL3 HOOK2 CLUH MST1P2 C16orf91 UBAP2L GTPBP3 AIMP2 DDX56 TMED4 YDJC UBE2I MRPL4 ZNF598 MAPK8IP2 VPS9D1-AS1 POLD2 MRPL20 MTX1 METTL1 SRCAP C1orf122 DIDO1 SIL1 NAT9 PARP1 SIPA1L3 BMS1 MFSD3 PMS2 COMTD1 MRPS15 CDK5 LARP1 GID8 LRRC14 ISG20L2 HDGF PYCR1 SNHG12 APRT EARS2 RNPS1 UBE2T ATXN2L PPM1G PFAS HMGA1 SNORA14B JTB PRCC TRMT2A PES1 NELFCD PPAN CHCHD10 PRMT5 C1orf53 BECN1 VPS72 ZGPAT NELFA DGCR2 HAX1 CROCCP2 VPS9D1 RANBP1 TMEM129 C22orf46 ZNF239 PPFIA3 GADD45GIP1 PELP1 GPR137 SCAF1 ZNF3 PPDPF GNL3L RANGAP1 RABGGTA MST1 SART1 ZNF444 MTND5P11 TMEM208 NSUN2 DDX42 FBXO34 UMPS SUPT5H DCXR ZNF785 RAD23A CBX3 NLE1 FPGS DUS3L PSMC4 PTBP1 DDX55 TP53 USP42 PHPT1 PRRG2 DPP9 PUS7 PUS1 TXNL4A PRMT1 MT-ND3 RRP12 MRPL11 TOMM40 ASPSCR1 ASNS KLF16 NOLC1 C12orf66 ARFRP1 DDX31 MT-CO3 SLC35B2 DPH1 TRA2A ATAD2 EIF3G SNRPE EIF2B4 PPIA PLAGL2 DDX19A GNB2 SNHG7 POLR2E THRAP3 UBFD1 TSR1 DIAPH1 PHF12 ING5 HDLBP MAP2K7 PPRC1 ACAD9 CCDC47 TACC3 ACACA ZNF839 RGL4 CAD NXT1 TMEM104 EIF1AD RPL36 USP54 RSL1D1 CHD2 SNAPC5 IDH3B HMGB3P22 KDM2A PA2G4 MARK4 CREBZF DNPH1 MCM2 GTPBP4 NCOA5 CCT2 ILF2 FBXW5 RN7SL1 HSPA9 PHF14 PLK1 WDR6 TRIM52 HCFC1R1 CENPT ORMDL3 L3HYPDH TAF12 HSD11B1L TAGLN2 F12 HSP90AB1 RAD23B TRNAU1AP PSME3 C1orf43 BANF1 MALAT1 RPL13 C8G UBE2S TNIP2 ZNF202 SLBP DHRS13 ZKSCAN2 AEN MRPS12 CPSF7 SPRYD4 RCCD1 ARPC5L VEGFA MGME1 TOP1 THBS3 PRDM15 RNF123 WDR60 RBM28 XPOT LRRC41 NDUFV3 G6PC3 ARF6 RTF1 ZNF574 RBM12B SRPRB MRPS35 NME1 NDUFS7 BIRC5 NME1-NME2 SNRPB UBXN6 EEF2K RPL37A PIGU POLR2A PNPT1 MRPL3 TIMM8B SPAG7 MEF2D STAG3L5P LZTR1 USE1 RPS15 RPL27 RPL10A SFT2D2 PABPC1 DCAF11 RPLP2 MRPL34 UBIAD1 RPL19 GIT1 POLR2D MXD3 NOSIP RPL22 COX17 DTD1 RPS20 NOP58 PPAT RPL18A WDR74 UBAP2 POLE4 SLC3A2 SRD5A1 RPSA NAPEPLD TIMM10 TM9SF1 FNBP4 RPS29 DBP PPIH LIPT2 AMPD2 VPS26B UQCRH ERICH1 MED15 SLC35F2 AP001372.2 RNF145 MDN1 SNRPF SMARCC1 BYSL CCNB1 DHX9 UFC1 RAD51D PFKP SEC13 RBM33 POLD3 C8orf33 DPAGT1 HNRNPF C2CD2L AP2A2 C17orf75 RPS14 GOSR1 AURKB KPNB1 HNRNPA2B1 FASN CDC42SE1 MORF4L2 MIRLET7I SF1 MAPKBP1 PGBD4 LGALS8 GLO1 ATP6V1E2 MRFAP1L1 TXNDC12 TAZ POLG AGBL5 ZNF131 NFE2L1 CTDP1 ARHGDIA NEAT1 RPL32 USP20 SENP2 RALGAPA1 UCHL5 UBC EZH2 RPS24 C6orf62 ERCC1 CFL1 BRCA1 RNF7 SDHAF2 UBE4A POLA2 BAP1 NRL RINT1 SNF8 CHTOP SLC35E3 NDUFA2 ZNF121 MRFAP1 WDR81 EID2 NCAPD3 COPB2 WNT10A RPS6 RAE1 SAR1B RPL23A COX10 MED20 LTV1 TRMT61B ARID4A GTF3C4 GLOD4 HIGD2A ULBP1 CASP8 SNX5 WDR43 ANP32B TSN NACA EIF2D JKAMP GEMIN7 DCAF4 PITPNA LRRC29 IK SARS2 SOD1 TBL1X NOP16 TRAM1 KIF23 DDX18 CANX PLEKHG2 C17orf100 HINT3 TXN LDHB AP2B1 MAP3K14 up
## ZC3H11A_TARGET_GENES 0.0011614 0.0084544 0.5285599 2.804578 0 811 PSMG3 SSU72 MLST8 MRPS34 TBL3 MST1P2 MRPL55 DUS1L MRPL24 WDR24 NOXA1 GTPBP3 ISG15 AURKAIP1 EDC4 LPIN3 SHARPIN PDCD6 ZBTB45 TARS2 THOC6 TRADD FAM207A INTS1 RAB40C CA11 ZNF786 MRPL20 B4GALT7 FBXO2 ZDHHC4 JMJD4 PVT1 NPLOC4 PARP1 TNRC18 NOL6 BMS1 KCTD5 SH2B1 NUDT8 RFXANK COMTD1 TUFM TMEM222 CIAO1 EME2 NOC4L GDF15 DGCR8 ZNF205 ZC3H3 PFAS TSEN54 HMGA1 BECN1 ADRM1 FAM71E1 YIPF2 SNAP47 GOLGA3 ZNF768 FEM1A C12orf76 DGCR2 ALKBH4 SNX18 SNRNP200 ZNF341 DDX51 TRUB2 CROCCP2 VPS9D1 KAT8 PIGG GAS8 SLC39A3 RERE IPO4 SLC27A5 KIF22 GPR137 AGK SRRT TMEM63A EMC10 CACNB3 GNL3L NDUFB10 UBTF RNF187 SART1 PPP1R37 DTX2 CDK5RAP3 USB1 TBX6 GEMIN4 LRWD1 TRMT44 ZNF74 GGA3 FBXO34 MBD6 SUPT5H ETV4 TMEM101 NLE1 SPATA20 PRKCSH INTS5 DDX55 CPSF4 PRRG2 RAB11B TRMU CTNNB1 TIGD1 HES4 C9orf163 LINC00853 CHMP1A UTP3 NELFB ARF1 FAM98C HMGXB3 DAGLB BSDC1 KLHL17 ZNF746 CCDC57 B3GAT3 CLDN23 ALDOA MRPL21 TMEM259 MRPL49 PANK4 TRMT112 PPIL2 EIF2B4 PPIA ILF3 PPP6R1 MCAT JSRP1 ZNF408 KDM3B DIAPH1 INO80B ASF1B ZNF76 RBBP5 ACACA CLK3 PRDX5 SPATA33 PTPRU TACO1 IGHMBP2 PHACTR4 ILDR1 MPHOSPH10 EIF1AD RPL36 LSM5 EXOC7 NKAP AMBRA1 CHMP2A CHD2 JOSD2 TYK2 ZC3H4 MARK4 RPL37 NUP107 DDIT3 KEAP1 COPS7B VPS51 SDC4 PSMG3-AS1 DPM2 FBXW5 COA6 DHTKD1 SMG7 MAZ MIR3189 NFKBIB HCFC1R1 MKNK2 ACSF3 CWC25 DNAJC2 MAPK8IP3 EXOSC2 NDUFS3 SCAND1 DRAP1 GART PSME3 GBA HNRNPA1 LTK BANF1 CCDC106 MLEC C8G XRCC2 PRAME KMT2C CYTH2 STOML2 DHRS13 TMEM147 NSUN4 CASP2 SHROOM1 NOL12 ZC3HC1 CPNE7 HSD3B7 RNF216 RBM28 TOP3B YTHDF2 ZNF276 NME1 NDUFS7 E2F2 EEFSEC XPNPEP3 NME1-NME2 TAF1C SLC37A3 DUS2 COQ4 AAR2 KIAA0100 RTEL1 VPS37B PSMD11 TRPC4AP DMTN ZMYND8 TUT1 RFX1 TMEM41A MKRN3 VPS25 MIR1205 HIRA TRIP4 PDE4A CDK11A WDR45B TNPO3 HEMK1 GTF3C5 SDHAF1 DRG2 AGMAT SSBP1 TXN2 STX4 GDPD5 PPARD CUEDC2 ZER1 TTC1 SF3A3 PSMC2 CLTB ATP13A4 NR1H2 PTCD1 TSPAN10 SSR4P1 DHX8 PSMF1 NOSIP MAN2C1 MAF1 RPS20 ZNF581 NAPSA TOR1B CSNK1A1 TIMM9 SLC25A16 DHX33 SAE1 ARHGAP1 GEMIN5 EP400 FAU SMG8 TXNRD2 PAK1 VPS13D NPAS1 SMG7-AS1 MED15 EI24 HUS1 GAK ZSCAN9 CRKL CYP4A22-AS1 ZNF554 SEC13 RTN4R CCDC12 CD63 ABCA17P ZNF580 C8orf33 C17orf75 AURKB KPNB1 SSBP4 FASN ERI1 UBE2H TMEM127 PHKA2 TIGD6 MPLKIP GGCX EVA1C C11orf49 COMT MVK AKAP9 LRRC37A3 CCDC58 SLC37A4 NBEAL2 ZNF165 NUDT5 PI4KA PMM1 NEAT1 KLHL20 MADCAM1 NUP214 CROCCP3 CDKN2AIPNL THEM4 RRP15 SNRPD1 C6orf62 TBC1D13 RUNX1 MAFA CCDC88B SPATS2L OLFM2 ABHD12 VPS28 PRPF18 SAFB FBXO28 RPS7 CHTOP CCAR2 PARP12 SLC35A3 TFE3 OSGIN1 MCM5 STX16 SAR1B SLC33A1 CASD1 TRMT61B CPSF1 ENPP3 HOMER1 FRS3 YEATS2 EXD3 CTNNA2 NR1H3 HPCAL1 FBXW8 ATMIN SFTA2 ACOX3 EIF4E2 ZMPSTE24 R3HCC1 EIF2D DENND1C ARL6IP4 GEMIN7 STX18 OGT TPI1P2 C6orf141 up
## ELF2_TARGET_GENES 0.0011820 0.0084544 0.5286953 2.789262 0 722 TBRG4 NUDCD3 FLAD1 RPAP1 TYW1 TELO2 TERC COASY UBAP2L WDR24 PHKG2 DDX56 CD2BP2 ZBTB45 GTF3C2 SLC38A10 AP3D1 SMUG1 WDR4 PEX16 OTUB1 TXNDC17 METTL1 SIL1 LONP1 NOL6 MRPL33 SH2B1 NCLN GON4L STX10 ATXN2L EVI5L RNF181 ENO1 TPRN MALSU1 BECN1 AP1M2 GMPPA LMAN2 SLC52A3 C12orf76 ARL16 FDXR CRB3 PICK1 LRCH4 SLC27A5 WDR34 MOSPD3 NFATC2IP RNF121 SHB FDPS TMEM208 OS9 HGS DDX42 CHCHD2 GTF3C1 RUVBL1 SIGMAR1 NVL RPS19BP1 CCT5 AP5Z1 MAN1B1 PRR14 ZSCAN25 PTBP1 ATP13A1 CDK11B AAGAB SETDB1 SPG7 RAB11B ELOF1 AATF LAMTOR4 NUP205 SND1 PPP4C RRP12 CLTA TOMM40 MRPL27 NDUFS2 EIF3I POLR1A PMM2 CACTIN SF3B2 TTI1 BAZ2A FIS1 PPP6R1 FZR1 FTSJ3 TMEM186 COPG1 SCAMP2 DIAPH1 PSMA5 PRSS16 UNC45A INO80B ZNF622 RPL38 CCDC47 STK35 RBBP5 ZNF384 ZMAT2 U2AF2 RNF4 CAPN10 CDK12 GPATCH2 LSM5 ARFIP2 ELAC2 BNIP1 RHOQP1 PHF23 C19orf25 RPL37 PIGT GGA1 GTPBP4 SMARCC2 VPS51 DDX19B DPM3 PHF14 FBXW9 ZDHHC5 GTPBP10 RPL11 CCDC61 MRPL51 CHMP4B ZNF787 ZKSCAN5 PSME3 C1orf43 ADPRHL1 POLR2F MLEC INCENP ZNF26 HSPBP1 UBE2S PNPO MRPS23 KLHDC4 ZNF688 SLBP CYB561D2 WDR83 PSMC5 RCCD1 DDX49 RPIA ZBTB17 RN7SL2 KLHL26 KIFC3 ACBD3 STAMBP SLC35C1 GHDC SEC23B EXOC8 LRRC41 NDUFV3 C19orf44 TMEM234 CNDP2 EIF5A CLPTM1 TRAPPC6A RBM42 FAF1 NUBP1 RPS3 PPP1R12C AGAP2-AS1 DUS2 UBXN6 PDCL3 AAR2 FBXO24 IRF2BP2 ZNF217 NPRL2 CYP51A1 APTX SPAG7 ACO2 VPS25 TRIP4 CDK11A LINC00893 STAG3L5P TNPO3 KIAA0556 USE1 SHKBP1 COPE RPS15 RPS27 EIF3D RPL27 TRMT6 RNH1 RAB11B-AS1 SSBP1 RPLP2 SAC3D1 MUL1 RPL27A DGUOK RPL19 KIAA0753 COPA RPRD1B TMEM183A ATP13A4 RNPC3 RPN2 ANKRD11 AHCYL2 ARMC5 DNAJC14 TOX4 RPL22 ZNF107 FASTKD5 RFWD3 COX17 UBOX5 BLOC1S3 ZNF581 LCMT1 PPCS RPL18 MFAP1 WDR74 SCYL3 MZF1 GSK3A CSNK1A1 DDX28 NCSTN AIMP1 ZNF837 ODF2 RAB27A SLC35A4 TIMM10 PARS2 STIL RPS29 DDX39A TMEM160 UQCC1 PHF5A UQCRH APMAP KATNB1 OSBP MBD1 ZNF394 MON1B MCM3 ZNF774 HAUS8 TFIP11 ZNF580 APBB3 UTP18 COX14 RPS14 NOA1 CXorf40A MPLKIP KTI12 PRKAB1 SF3B5 CDC42SE1 UBXN1 RIN1 TXNDC12 SLC25A14 VRK3 NUDT5 RPL29 ZNF317 SPHK2 NUP214 RPL32 MED19 AC092118.1 AP2A1 THEM4 TBC1D22A EXOC4 C6orf62 FDFT1 EME1 NCAPD2 MRPL54 SPRTN AIP SPATS2L LRPPRC UBE4A COPS7A MCM8 EIF3H GOLPH3L PTCD3 SNF8 SMARCAL1 CEP164 MCTS1 TMEM198B RPS7 ANKRD13A SNIP1 UQCRC2 CENPL CHMP4A TCTA COX8A COPB2 ARHGAP12 SLC35A3 BCL2L13 ELL up
## DIDO1_TARGET_GENES 0.0010977 0.0084544 0.5106334 2.786542 0 1381 NUDCD3 PSMG3 SSU72 FLAD1 MRPS34 TBL3 HOOK2 GPATCH4 TELO2 COASY MRPL55 C16orf91 ZNF623 UBAP2L RER1 WDR24 C1orf35 NMRAL1 SMG5 GTPBP3 C7orf50 ATAD3A EDC4 ATAD3B FARSA SHARPIN OPLAH UBE2I CSTF2 TARS2 DHDDS UFSP1 ABCB8 FAM207A FBXL18 INTS1 ADAR POLR2J WDR4 PEX16 ZNF629 MRPL20 QTRT1 ZNF212 MORC2 JMJD4 BMS1 KCTD5 MRPL33 ALG3 NCLN SYT12 MRPS15 ABCF2 GUSB CCDC86 CHD8 EME2 NDUFV1 NOC4L EIF2B5 UBE2Q1 DGCR8 ZNF205 ECE2 GUSBP1 AARS2 ATXN2L FAM220A EBNA1BP2 MEN1 RPTOR SMPD4 DBNL NOP14 PES1 SNHG11 MALSU1 PGAP3 AUP1 BECN1 RPUSD2 HAGH VPS72 ERBB2 ZGPAT LMAN2 YIPF2 SNAP47 GOLGA3 TRAPPC9 COMMD4 NELFA FEM1A C12orf76 SEC24C MZT2B STARD10 MTOR FEN1 DOHH MGRN1 MFN2 DDX51 CCNL2 TRUB2 AHCY LAS1L PIGG SLC39A3 KNOP1 IPO4 SLC27A5 KLHL12 GPR137 BRMS1 TJAP1 PRMT7 HARS2 ZNF3 AP4M1 CCDC124 ALG1 RECQL5 YKT6 RNF187 HPS4 POLL WDR34 RABGGTA SART1 CXorf56 PNKD URB1 PSMD3 STAT6 PPP1R37 SNHG17 NDUFB7 CHCHD1 TMEM208 NHP2 ASB6 MRPS33 NSUN2 SLC35B1 TRMT44 NAT10 UMPS BPNT1 SLC35E1 TMEM101 RUVBL1 BAD ZNF785 TSFM NVL TUBGCP6 PRKCSH NDOR1 ROMO1 TNPO2 PRR14 ZSCAN25 CCDC159 INTS5 MZT2A DDX55 KMT2D CDK11B FAM50B TMED9 SETDB1 AAMP MACC1 WDR62 ADPRHL2 TRMU CTNNB1 TIGD1 THTPA PCCB GBAP1 GORASP2 NUP205 CDK5RAP1 MRPL27 HMGXB3 DNAJC16 FAHD1 ZNF263 MRPL9 CACTIN COX19 ARFRP1 THAP8 DDX31 TTC31 NGDN DPH1 ATAD2 EIF3G PANK4 RPUSD4 SNRPE PSMC3 ZNF526 HMOX2 MCAT CCT7 SSNA1 METTL7B ZNF408 ANGPTL4 NABP2 INO80B SLC4A1AP RRP1B ACAD9 ZNF514 MCM7 RBBP5 ENDOV CLK3 ZMAT2 MED8 CDK12 EFTUD2 TACO1 WDR53 BLZF1 MPHOSPH10 EIF1AD POLR3A RPL36 NKAP SZT2 AMBRA1 BNIP1 ELMOD3 SNAPC5 IDH3B MARK4 RPL37 SRRM5 NUP107 PIGT LINC00630 GGA1 COPS7B FIZ1 MIS18A TMEM79 METTL2B SUPT16H MNAT1 VPS51 DPM3 TMEM203 PSMG3-AS1 XYLB SMG7 ANAPC2 FBXW9 ZDHHC5 GTPBP10 DCTN5 CXXC1 DFFA MRPL37 CWC25 POLR2J3 ORMDL3 TOMM40L WWP2 HSD11B1L NDUFS3 LRRC59 SCAND1 MED18 ZC3H18 PSME3 GBA C1orf43 MCRS1 BANF1 MLEC EDC3 CCDC142 ZDHHC16 OAZ3 ZNF26 PRAME ZNF830 MRPS23 KLHDC4 VPS41 ZNF688 MRPL48 LSG1 STOML2 FBXL12 ZKSCAN2 WDR83 SLC7A6OS C19orf47 TMEM248 NOL12 ZC3HC1 RPIA SAP30BP ZBTB17 STK16 VAC14 RNF216 C1orf74 TMED1 AGA ACBD3 HEATR1 CDCA7 COA1 RBM28 NDUFV3 TOP3B EIF5A CLASRP CLPTM1 RBM42 MRPS35 NME1 NDUFS7 EEFSEC NME1-NME2 FAF1 NDUFA11 LSM10 SNRPB RPS3 PPP1R12C TAF1C SNRPC TSKU DUS2 PSMB3 UBXN6 COQ4 COQ9 BRPF1 AAR2 RTEL1 TRPC4AP PEX14 SPATA2 TUT1 MRPL3 TMEM41A APTX SIN3B ACO2 MKRN3 NUP85 VPS25 HIRA TRIP4 VMAC KCTD2 TNPO3 HEMK1 USE1 GTF3C5 ZSCAN21 CASP9 GOLGB1 RPLP0 DRG2 ZSCAN31 TRMT6 EHMT1 TSR2 TXN2 WDR25 INTS7 ZER1 TOMM22 TTC1 PEX13 TMEM205 APBA3 SF3A3 KCNH2 COMMD5 ZNF689 ATP13A4 RNPC3 ECSIT SRP54 CTSA ST7-AS1 RRP36 TOX4 PSMF1 NAGPA MED24 SPATA5L1 MAN2C1 MAF1 SNORD104 PALB2 ZNF335 RPS20 TMEM258 ZNF581 SNRNP35 RPL18 TOR1B COX6C BRD7 DHODH SCYL3 SP2 TIPIN SRD5A1 CIAPIN1 DHX33 PMF1 AIMP1 ARHGAP1 TIMM10 RPS28 PPCDC SDHB TFAP2A SMG8 UQCC1 SMARCD2 NFS1 PHF5A VPS26B RAD54L RPA3 POGZ C19orf81 GPATCH3 SMG7-AS1 RETSAT MED15 RAB3D EXOSC1 HUS1 SCAP AURKA DNAJB12 KATNB1 TTC13 ZNF394 ZSCAN9 RRN3 ZNF16 ZNF524 SNRPF SLC52A2 UFC1 CKAP5 PINX1 SEC13 FAM200A ABCA17P TFIP11 ZNF580 POLD3 C8orf33 ZNF133 ERI3 BOD1 DPCD DPAGT1 C2CD2L C17orf75 RPS14 MTMR4 MPZL3 MAU2 PARGP1 TWISTNB SP8 NEK2 ATL2 BRIX1 RMDN3 TMCO1 PFDN4 FAM118B MMACHC MTX2 ERI1 IQCC LEMD2 TIGD6 MPLKIP POLR2J4 DNAJB11 SNRPD3 BMS1P1 FRS2 C11orf49 SUGP1 SLIRP ZSWIM8 MAP2K1 PEF1 CCDC58 ZNF131 ZNF165 NUDT5 RPL29 NFE2L1 CTDP1 IRGQ KLHL20 ZNF317 CCDC97 SPHK2 MED19 GEMIN6 EXO1 CDKN2AIPNL THEM4 RRP15 METTL17 SNRPD1 UBC EXOC4 TARDBP GUCD1 NFX1 EME1 TBC1D13 TBCD USP40 HSF2BP MRPL54 CCZ1 RPL26 UBE4A BPGM MCM8 SFSWAP C1QL4 EIF3H TRMT5 PRPF18 SUCLG1 LARS2 NUP133 ANKFY1 KAT5 MCTS1 LINC00680 ESF1 PSMD8 FBXO28 RPS7 SNIP1 CSTF1 LINC00115 CCT4 CCAR2 CHMP4A ACCS NCAPD3 RPL9 FBXO45 CLPX ARV1 STRIP1 SLC35A3 WSB1 C12orf43 PGS1 LONP2 KLHDC9 CACYBP STX16 ATR NRDE2 FARS2 DNAJC1 SAR1B DNM1P35 ZBTB40 LUC7L ZBTB8OS DEPTOR ZDHHC7 PDCD7 FAM162A LTV1 CAMK2D HNRNPA0 TRMT61B GLOD4 CCZ1B ENPP3 SLC9A1 SEC11C ZFHX2 BBS5 CNOT2 MRPL44 IPPK NR1H3 ZNF200 TSN SFTA2 ACOX3 HARBI1 EIF4E2 MAGOH SUPT7L NUP155 POLR2C EIF2D ST7 RPS26 GEMIN7 GZF1 LRRC29 GNG4 STX18 TPI1P2 TSEN15 TFCP2 NOP10 up
## JDP2_TARGET_GENES 0.0010741 0.0084544 0.5065766 2.783369 0 1661 NUDCD3 SSU72 C1orf226 DNAJA3 CLPTM1L TYW1 TBL3 CLUH TELO2 RCE1 MRPL55 CBX4 MRPL24 C16orf91 KCTD13 RER1 PUSL1 PRPF6 DNTTIP1 OGFOD3 SMG5 ISG15 ATAD3A PPP1R35 CHID1 FADD FBXL19 EEF1D PDCD6 TRIM11 REPIN1 MTG2 LETM1 GDPGP1 DHDDS CABIN1 AP3D1 WDR4 PEX16 CCDC127 ZNF696 WFDC3 AP1S1 PEX10 MRPL20 YTHDF1 C1orf122 DIDO1 ZDHHC4 JMJD4 FOXRED1 NR2C2AP SIL1 NAT9 SLC22A18 RCC1 EIF2AK1 CTBP1 CC2D1B USF1 PC ZNHIT1 MRGBP RFXANK DDX23 USP39 MRPS15 P4HB RHOT2 WDR18 LARP1 GID8 LRRC14 TMEM222 HDGF CBX8 GFER USP21 GON4L MROH1 UBE2J2 CIAO1 CHD8 GCDH PYCR1 BLOC1S4 POLRMT NOC4L SLX4 CDC34 SRM GDF15 TIGD5 MAP3K9 DNASE1 KRT80 CANT1 CIB1 FAM220A TIMM44 ZC3H3 PFAS SNHG3 CCS SNORA14B PRCC ATP6V0E2 TMED3 TRMT2A SMPD4 ANAPC11 TK1 TUBG1 NOB1 EXOSC5 TRAP1 SNHG11 ENO1 NELFCD RABL6 PARD6A PRMT5 ACAP3 C1orf159 PDAP1 CNNM4 RRP1 ADRM1 HAGH ZNF12 MRPL12 BCL9L AKAP1 YIPF2 SNAP47 CDK2AP2 MZT2B ALKBH4 PDP1 SNX18 ARL16 PDXP TMEM63B SNRNP200 MRPL14 MFN2 ENTPD6 TMEM175 ACOT8 DDX51 THOP1 CCNL2 MNT HAX1 WIPI2 MYPOP ACD ABCF3 RANBP1 NUMA1 PLCB3 DNAJC5 PPFIA3 RERE POLR2H PELP1 IPO4 SCNM1 KIF22 ZNF3 PLEKHH3 AP4M1 CCDC124 TDRKH RECQL5 STK40 RANGAP1 YKT6 UBTF HPS4 DNAJB2 MST1 SART1 PNKD PSMD3 HAUS5 CCDC87 HMBS UCKL1 SPEN ALYREF NCDN ZSWIM3 DHX34 CYHR1 TRAPPC3 MRPS33 ARPC1A LRWD1 TRMT44 HGS DDX42 TTLL12 NAT10 FBXO34 MBD6 GTF3C1 SUPT5H RPS6KB2 POP7 GRHL1 NOP56 RAD23A ZNHIT2 CBX3 B3GNTL1 SBF1 MVB12A CCT5 ZFYVE27 SLC35C2 CDK4 RNF126 TMEM201 ATP13A1 PHPT1 CDK11B RNF213 E2F1 TMED9 POLR3E XPO5 KIFC2 SPG7 DPP9 MAGEF1 AAMP MRPS6 ADPRHL2 PUS7 HES4 PTPN23 SEC16A PLOD3 NMT1 CMTR1 ARF1 RAB24 FLVCR1 REXO1 TLE6 GNAS RRP12 SUN1 TOLLIP-AS1 ASPSCR1 NUTF2 FAHD1 KXD1 DAGLB CHERP NOLC1 BSG ARMC6 DTYMK WRNIP1 MEX3D CACTIN FBXL19-AS1 SIGIRR CNOT11 ZBED4 DDA1 MRPL49 RBM47 RNASEH1 DDX19A ZNF526 RABIF ILF3 PPP6R1 WDR59 GNB2 PTOV1 FZR1 MRPL36 JSRP1 SSNA1 EIF4G3 COPG1 NEIL2 SIRT6 PIAS4 TRIM28 PSMD2 SDHA ING5 INO80B MAP2K7 CBR3-AS1 OSBP2 TBCC ACBD4 RPL38 SLC4A1AP ACAD9 PARK7 CCDC47 ZNF514 MCM7 ZNF865 MRPL17 XPO6 DCTPP1 U2AF2 CDK12 WDR73 ARMC7 WDR53 NARS2 RNU5A-1 BLZF1 TMEM104 PPFIA1 RPL36 LSM5 ZNRF2 PARN MLF2 CUEDC1 CHMP2A CHD2 ELMOD3 SNAPC5 IDH3B POFUT2 ZNF784 PHF23 HMGB3P22 KDM2A PA2G4 SRRM5 NUP107 PIGT FAM13A DDIT3 TEX264 SREBF1 MIS18A RNF43 EXOSC10 NCOA5 TMEM79 VPS51 TPR ILF2 ZXDC FBXW5 TPD52L2 C19orf73 DHTKD1 PAK1IP1 PHF13 ANAPC2 IRF2BPL DFFA SNORD46 CENPT PREB MED9 ZWINT HSPD1 CHMP4B RNU5E-1 ORMDL3 MAPK8IP3 METTL2A HSD11B1L TMEM219 UBR4 LRRC59 PAICS HSP90AB1 RPL8 RAD23B DRAP1 TRNAU1AP CCDC51 GBA TAOK2 MVD MALAT1 C8G XRCC2 ESYT2 PPP1CA MRPS23 HNRNPU MTHFSD LSG1 XRCC1 TOLLIP CIC CYB561D2 RAD50 DYNLL2 CASP2 GATAD2A CRTC1 ASB16-AS1 LIPE TOP1 FGFBP3 SAP30BP LINC00337 CPNE1 MORN1 C1orf74 UXS1 RNF123 IER5 WDR60 R3HDM2 SEC23B TSPAN31 TRAPPC1 EXOC8 XPOT SNORA37 NDUFV3 CDPF1 EIF5A SNRNP70 KIAA0319L RBM42 MGMT TMUB2 CBX1 FAF1 PAF1 PRPF39 PPP1R12C RRP7A CDCA5 LYSMD1 TOM1 MRPL38 RPL37A CHCHD4 TUT1 UBE4B ZNF217 SLC1A5 NPRL2 ENC1 CNTROB WDTC1 TMEM41A IMPDH2 GEMIN2 MEF2D CDK11A STXBP1 CDYL PGAP2 KIAA0556 SEC61A1 BCL6 CASP9 AKR7A2 ZNF517 RPL27 TRMT6 PARP2 RPL10A EHMT1 PABPC1 TXN2 AKT1S1 INTS7 C11orf24 PITRM1 TTC1 PDRG1 FANCA NCAPG2 RPS16 ZNF7 SCAF4 COPA SCFD2 ATP13A4 MMS19 NR1H2 ANKRD11 AHCYL2 POLR2D ARMC5 PIGM STOML1 FITM2 KANSL3 RBAK YRDC TFB2M ZNF335 CREBBP DTD1 SUGP2 RAB3A NFRKB RPL18 ZFAND2B PPAT GSK3A RSBN1L CSNK1A1 SLC3A2 TIMM9 HOMEZ RNU5B-1 BUD31 BAG3 TIGD2 MED29 NCSTN TRIT1 LPIN2 SAE1 STX6 NAPEPLD PITPNA-AS1 ANKRD24 RPS28 PPCDC SDHB FAU SAP130 RPS29 TMEM160 DSN1 NDUFC1 UQCC1 AGR2 RPL3 DBP PIGX FAM177A1 OXSM COX7C ARID4B RPA3 IFT140 MATN1-AS1 SDR39U1 EIF3A RETSAT ERICH1 MED15 YEATS4 PRELID1 SCAP ULK1 SURF4 GAK RNF145 ZNF775 MBD1 NUP188 H6PD ICMT CRKL ACTR1B FAM193A SLC52A2 GPI UBALD2 LARP4B PCGF3 MCM3 BCL2L15 OXA1L ZNF554 ZFP36L1 MIF4GD TSSC4 DSCC1 GLCCI1 MLXIP ZNF653 POLH SH3GL1 RNF19A ANLN ABCA17P GNB1L RAD9A RPP38 SRSF1 ERP29 AP2A2 NSFL1C KIF18A TOMM20 RPL13A HNRNPA2B1 MED26 BRIX1 C12orf65 WDR89 RMDN3 ERI1 ZNF747 TMEM127 CDC6 STT3A PRKAB1 SF3B5 BOP1 XXYLT1 SF1 UQCR11 CRELD1 UTP6 TBCA S100A11 HDAC7 MAPKBP1 HNRNPM PGBD4 C20orf27 ERI2 HM13 ATP6V1E2 MTG1 NUCB1 UBTD1 PPA1 RAC1 MGA AKAP8 DCAKD PPP2R5B DCAF13 CSK PMM1 OPA3 NDUFAF3 UBE2V2 GGPS1 IRGQ NEAT1 MEAF6 CCDC97 MADCAM1 SPHK2 NUP214 SPDL1 DLGAP4 PDIK1L SENP2 SLC9A3R1 NUB1 U2AF1L4 SLC7A1 CXorf38 INTS4 BUB1B NFX1 ERCC1 UQCRC1 SPAG1 PTTG1IP DISP2 TBCD SNAPC2 SPRTN MAFA RNF7 MLLT3 SPATS2L CKAP2L UBE4A SNX12 POLA2 MCM8 LARS2 HSPA8 SAFB PCNA FSTL4 SIX5 UBAC2-AS1 DYNC1H1 IMMT PSMD8 USP10 RFX2 LARP1B RANBP3 ARHGEF18 WDR81 CCAR2 EID2 ATP2A2 COX8A RALGDS COPB2 RPL9 WNT10A FBXO45 DDI2 INPP4A STRIP1 BCL9 ELL ZNF79 PGS1 TBC1D10A SLC35F5 OLA1 DALRD3 CDCA4 CMIP ZBTB40 SLC33A1 ZDHHC7 MTA2 CKLF-CMTM1 TAB1 CAMK2D CASD1 UBN2 TRMT61B CBX6 UBA52 TIPARP SLC9A1 SMG9 CIRBP WDR43 RPL23 NAE1 DUSP10 FRS3 PPIF MRPL44 ALKBH6 PELI2 PSMA3 TBC1D17 FBXW8 TSN ATMIN ACOX3 UBL7 ZMPSTE24 MAGOH SUPT7L MAP2K3 GZF1 RPS8 DOLK ACTN4 STX18 PAOX TSEN15 SPECC1L-ADORA2A HOXB9 PPM1A AFMID NUBPL ZFPL1 up
## RBM34_TARGET_GENES 0.0011534 0.0084544 0.5221898 2.780349 0 846 PYGO2 RPUSD1 FASTK ASL RMND5B RER1 NMRAL1 OGFOD3 MGAT4B CHID1 AURKAIP1 EDC4 JMJD8 B3GALT6 PDCD6 CABIN1 FGFRL1 TONSL FAM207A SLC38A10 AP3D1 CHPF2 RAB40C POLD2 ZNF786 MRPL20 ZNF212 CTTN LRRC45 NAT9 ATIC LONP1 MRPS2 E4F1 KIAA1522 SMYD5 CHTF18 USP39 P4HB TMEM177 CRELD2 DHCR7 ADAM15 GFER CDH15 SLC12A9 PDIA4 NECAB3 ZNF398 APRT NME4 RUNDC1 RNPS1 DGCR8 CAPN12 NAA40 TRMT2A ANAPC11 STK11 TUBG1 CLCN7 CAPN1 DECR2 SQSTM1 SRRM2 ADRM1 SLC25A10 YIPF2 FOXK2 TRAPPC9 NELFA CDK2AP2 ALKBH4 PDP1 PKMYT1 ZNF174 TMEM175 CCNL2 MOCOS VPS9D1 RANBP1 MKRN1 TMEM129 PRSS27 DNAJC5 PPFIA3 ZSCAN32 SOX12 SDF4 AVL9 CAMK2G RRBP1 SPATA2L TP73-AS1 ATG4D ALYREF KRI1 CYHR1 EDF1 LSM7 LRWD1 PAXIP1 TTLL12 MBD6 LMF1 FBXL16 DCXR SNAPC4 ARFGAP1 FPGS UBE3C IRF7 BAHD1 SLC35C2 EPS8L2 HMG20B DDX55 E2F1 MIB2 KIFC2 ETFB SPG7 DPP9 WDR62 TRMU ZNF778 IMPDH1 GORASP2 STXBP2 PPP4C FLYWCH2 SUN1 DNMT1 PKM CCDC57 WIZ WRNIP1 SF3B2 THAP8 ATP11A PIP5KL1 CERS2 QSOX1 CNOT11 TIRAP TMEM259 CD55 PANK4 MYO6 MIEN1 PHRF1 ZFP64 HMOX2 DPH7 SAMD4B ABHD14A NUDT1 SLC2A8 TRIM28 GLI4 MCM4 PARK7 GMEB2 ARPC1B TACC3 LZTS2 PDXDC1 SEMA4F MIOS TMEM104 PCNT TXNDC11 SPPL2B RPL36 LSM5 ACSS2 MAD2L2 PRKDC BCKDK ADAMTSL5 SREBF1 TOR2A MIR4449 KIAA0895 ANKRD16 MAP3K10 C19orf73 XYLB MBOAT1 AHDC1 ENO3 MKNK2 POMT2 ZNF425 MAPKAPK3 HSD11B1L LRRC59 SLC7A5P1 CIZ1 C15orf39 MVD HTT NBPF3 KAZALD1 KCNK5 SPIRE2 SCMH1 ANXA11 ALAD HNRNPU UNKL TUBB2A TNIP2 SBNO2 TUBB4A TMEM147 SLC7A6 WDR83 LINC00482 GATAD2A AMACR RCCD1 ARPC5L RPL35 MORN1 HNRNPUL1 VSIG10L CDCA7 AGPAT3 IL27RA NDUFV3 SHMT1 EMC8 ZNF276 HOXC-AS1 TALDO1 LRRC27 CLN6 RIC8A EEFSEC GALK1 HIBADH PROCA1 SUCO SGSM3 DHX30 COX4I1 MRPL38 PSMD11 FHDC1 PIN1 SMARCB1 SLC1A5 MON1A WDTC1 TCIRG1 HDDC3 TADA2B HIRA WDR45B STXBP1 TECPR1 PGAP2 BCL2L1 MCM10 ZNF517 NF2 PPARD OAT ZER1 RPLP2 PITRM1 LRRC37A6P SLC8A2 PTPN18 FANCA MRPL34 NLRX1 ASH1L RAB40B SURF2 LMNA FRMD8 ANKRD11 CTSA GALNS YRDC MAN2C1 CNNM3 GIGYF2 TCF25 COX17 TOR1B BRD7 POLE4 NOD1 PPM1H TMEM189 ZNF837 ACTL6B FN3K FAM131A TRIM45 TFAP2A BRSK2 DBP LIPT2 TRIM14 C16orf70 PLCG1 ERICH1 ZNF77 SLC35F2 AP001372.2 SCAP APMAP GAK ZNF775 CRKL ACTR1B LARP4B ZNF774 DENND6B RBM33 ZNF653 HADH CCDC12 MYH14 FANCE RPP38 POLD3 KDM4B NSFL1C C2orf68 NDUFAF6 NMU STK32C KPNB1 GPSM2 TMCO1 EZR DAG1 SF1 IMPA2 NFKBIE TRAPPC2L MTG1 TAZ FIBCD1 PUF60 ACTR3C NBEAL2 KISS1R P4HA2 CHGB FH KIF1B HABP4 SPHK2 EIF2AK4 RHBDF2 ZNF367 USP20 ARVCF PACS1 UCK1 STRIP2 CDKN2AIPNL NUB1 RN7SL521P FZD5 DANCR CTBP2 MBTPS1 FHL2 ERF TBCD CFL1 SNAPC2 PIEZO1 NDE1 IZUMO4 ACADS PUM1 SRRM2-AS1 MPZL1 IMMT NETO2 ACOT7 RNASEH2C RFX2 PDIA3 CCAR2 BMP8B RALGDS ZNF18 SLC35A3 HTATIP2 PGS1 SPRED1 PSD SLC25A43 GMPPB STX16 SLC25A13 DBNDD2 ABCB10 RNU6-2 SPIRE1 REEP4 MRPS28 CPSF1 ELMO2 PLOD1 CEP55 CIB2 DRG1 TANGO2 COX5A C2CD2 RPA1 INCA1 ASB1 ATOX1 TUBGCP5 CECR7 GORASP1 ACTN4 UNC93B1 SPECC1L-ADORA2A C1orf216 PANK2 GSTZ1 CCDC112 PPARA up
## SCGGAAGY_ELK1_02 0.0011173 0.0084544 0.5137774 2.780056 0 1148 SSU72 RPAP1 SAMD10 NOC2L DPP3 KCTD13 RMND5B PRPF6 DNTTIP1 PPP1R35 CHID1 EDC4 B3GALT6 TMUB1 RBCK1 CD2BP2 TRAF7 PDCD6 TRIM11 WDR55 TRADD TRPT1 GTF3C2 FBXL8 NUDT22 SLC38A10 SMUG1 PEX16 OTUB1 WFDC3 E2F4 APEH PIGO C1orf122 TRMT1 ZNF687 FOXRED1 ITPA KCTD5 MRPL33 EIF2AK1 USF1 LYPLA2 DPH2 ZNF646 KLHL35 RFXANK NUDC TUFM TMEM222 CBX8 WRAP73 PCGF1 GON4L TRIM41 CIAO1 LSR ANKS3 RNPS1 STX10 NTHL1 MARK2 TSTA3 EBNA1BP2 ZNF48 RNF181 RRS1 EXOSC5 PPAN PDAP1 BECN1 ATG16L1 LSM4 LMAN2 CLCN2 GOLGA3 SEC24C DHX37 FDXR TSC2 CRB3 PICK1 MKRN1 PDZD11 COG4 LAS1L POLR2H IPO4 GALNT10 HARS2 AP4M1 GGT7 CDK13 DNAAF2 GNL3L STK40 YKT6 POLL WDR34 RABGGTA SART1 CXorf56 GRWD1 MOSPD3 VPS53 F11R C19orf57 CLDN7 RNF121 USB1 TMEM208 TFAP2C ING2 DAGLA ASB6 TBX6 NSUN2 TMEM62 DDX42 EML2 GPN2 GTF3C1 SUPT5H TMEM101 MRPS18A BAD POLR1C PPME1 RAD23A ZNHIT2 ARFGAP1 GNL2 RPS19BP1 YIPF3 MYL6B GSE1 PSMC4 ZFYVE27 SLC35C2 ROMO1 ZSCAN25 DDX55 TP53 ATP13A1 AAGAB LRP10 CCDC130 XPO5 GRIPAP1 SETDB1 AGPAT2 BZW2 RAB11B KRTCAP2 FIBP PRPF19 BCAT2 PTPN23 PUS1 ZSCAN29 AATF UTP3 CDC37 NMT1 RAB24 SND1 STXBP2 XAB2 PPP4C TOMM40 MRPL27 NUTF2 KXD1 DNMT1 EPN1 KLHL17 CHERP WFDC2 VPS18 B3GAT3 C12orf66 PMM2 ALDOA SIGIRR MRPL49 TRMT112 PPIL2 SNRPE SF3B3 MIEN1 ZFP64 PSMA6 CCT7 RAVER1 ZNF408 KDM3B TMEM186 SCAMP2 DIAPH1 SIRT6 PSMA5 INO80B MRPL52 TBCC SH3GLB2 CCDC47 MCM7 RBBP5 MLLT6 ENDOV ZNF384 ACIN1 EFNA5 PRDX5 U2AF2 MED8 SUPT6H WDR73 EFTUD2 ARMC7 TBCE BLZF1 PEX6 MPDU1 EIF1AD GPATCH2 LSM5 ARFIP2 SZT2 CHMP2A HIRIP3 JOSD2 ADAMTSL5 PHF23 RPL37 NUP107 PIGT DDIT3 PGAM5 GAR1 BABAM1 GGA1 DLX4 CREBZF COPS7B GSPT1 CHPF TYMP SUPT16H SIRT3 MFSD9 TAX1BP1 SRSF4 PCED1A FBXW9 ZDHHC5 NFKBIB CUL7 DCTN5 CXXC1 ZNF513 RPL11 CWC25 C1QBP MAPK8IP3 TTPAL UBR4 HSP90AB1 DDOST ZKSCAN5 C15orf39 GART PSME3 SHANK2 MCRS1 POLR2F ZNF70 BANF1 MLEC TPGS1 MAD2L1BP ALAD STOML2 CYB561D2 SPRED2 RPL36AL CSNK1E C19orf47 CPSF7 DDX49 NOL12 TNK2 NMNAT2 COG7 MAP3K11 VAC14 POLR3H VPS16 GLE1 TSPAN31 TRAPPC1 LRRC41 YTHDF2 COX6B1 C1orf210 EIF5A CLASRP ENTPD8 EEFSEC SNRPB RPS3 SLC25A5 PSMD13 CSAD DHX30 RPL37A C12orf10 MRPL3 NPRL2 CNTROB APTX ACO2 HDAC10 HIRA TNPO3 RPS5 SEC61A1 BCL2L1 USE1 TMEM191A SHKBP1 COPE GMPR2 TRIM46 SPICE1 RPL27 TRMT6 INO80E FOXH1 SSBP1 KIF4A PABPC1 SHC1 STX4 ZNF668 AKT1S1 ZER1 TOMM22 RPLP2 DGUOK PITX2 SF3A3 MFSD5 PSMC2 RPL19 ERCC3 COMMD5 SCFD2 NR1H2 CES2 SRP54 MRPS21 RRP36 DNAJC14 DHX8 KANSL3 NOSIP YRDC TFB2M FASTKD5 PALB2 ZSCAN20 WNT1 COX17 FAM120A SLC12A2 RPL31 WDR74 MGAT2 TPM3 SRD5A1 FAM219A BUD31 GAPDH TAF5L ARHGAP1 STX6 ODF2 TIMM10 TM9SF1 PARS2 SAP130 NFS1 TPX2 PHF5A THAP11 POGZ TAF10 MSANTD2 UQCRH MED15 FAM120AOS PRELID1 AURKA KATNB1 ZNF394 RBM19 GDE1 SLC52A2 GTF2A2 C9orf40 MON1B UFC1 RAD51D HPS1 PHLDB3 TIPRL SEC13 FAM200A PABPC4 SYT5 TCOF1 ZNF653 POLH AP1B1 MEA1 ZNF580 DPCD RPS14 MTMR4 MPZL3 TOMM20 COX5B MLYCD TMCO1 MTX2 ERI1 TMEM127 TUBGCP4 ZBTB41 TIGD6 HSPA4 KTI12 PRKAB1 UBXN1 FRS2 MAP3K6 SF3A1 ERI2 TXNDC12 SUGP1 SLIRP ZSWIM8 SLC25A14 PUF60 PPIL1 CNPY3 DCAKD VRK3 NUDT5 NDUFAF3 UBE2V2 RPL32 VEGFB TBC1D22A RRP15 CELF1 URM1 EME1 ERCC1 LASP1 DHX57 TBC1D13 EVX1 MTF1 TGS1 AIP RPL26 RAB4B SDHAF2 MTFR1L SDF2 UBE4A SNX12 COPS7A MCM8 SFSWAP SRSF9 EIF3H PRPF18 SNF8 KAT5 CEP164 SLC25A4 MCTS1 SNIP1 CSTF1 MYO19 ITM2C CTPS2 AGL TCTA ATP2A2 COX8A UGGT1 CLEC18C WRAP53 MRPL43 ZNF79 SLC25A17 PGS1 LLPH UHMK1 EP300 RPS6 ATR TADA3 SIPA1 DNAJC1 RNF41 PER2 UBLCP1 ZBTB8OS MTA2 LTV1 ARID4A CCZ1B CEP55 EDEM3 KRIT1 YEATS2 CPT2 IPPK TBC1D17 ASB1 NIF3L1 FUT8 NUP155 EVC2 NAA60 PROSER1 STIM1 PITPNA LRRC29 RNF20 RSPRY1 TPI1P2 ENOX2 CETN3 TFCP2 PSMC1 CCDC71 GMIP SON MOCS3 UBL5 SLC9A8 FBXL6 BCKDHA SLC35F6 NASP FBXO33 EML3 NMNAT1 HERPUD2 STARD3 ATXN10 EAPP POLR3D CAAP1 SEC23IP CCDC85B PRKAG1 FBXO38 up
## ZMYM2_TARGET_GENES 0.0014881 0.0084544 0.6261475 2.747492 0 115 EEF1D SHARPIN DAP3 PPP1R14B GET4 CHMP6 GDF15 TIGD5 MARK2 RN7SL3 PFAS ADRM1 AHCY GALNT10 RAC3 ZNHIT2 PRDX2 FAF2 PPP4C MLLT1 DAP WRNIP1 MIDN PPIA EIF4G3 CDH3 STK35 NR6A1 ZC3H4 FBXW5 TJP3 GAMT YY1AP1 ADPRHL1 RCOR2 C8G LINC00337 MPST LRRC27 HIBADH RFX1 PDE4A CDYL PPP1R13L NLRX1 CDC25B RPL28 MAF1 CREBBP SAE1 SMARCD2 TST ICMT SERINC2 PCGF3 TMCO3 HAUS8 RNF19A AP2A2 RPS14 DOT1L RAC1 NEMF RHEB PPIB CD3EAP CENPN AIP up
## NPAT_TARGET_GENES 0.0013643 0.0084544 0.5736789 2.724479 0 204 MLST8 DNAJA3 MST1P2 SMG5 FADD SMARCA4 JMJD4 LONP1 BLOC1S4 FBRS FAM220A SNORA14B ATP6V0E2 TRMT2A NPRL3 RRP1 FAM71E1 ZNF12 SNAP47 ENTPD6 CROCCP2 RANBP1 PAGR1 EMC10 CEP250 LSM7 NVL MAN1B1 TOLLIP-AS1 ASPSCR1 DAGLB ARMC6 SEC61G PPP6R1 FAM222B SIRT6 PHF12 CD320 THOC3 ENDOV TIMM13 CDK12 SPPL2B THAP7 RPL36 SAMD1 FXR2 PHF23 HMGB3P22 SRRM5 MIS18A TMEM79 VPS51 ZDHHC5 PREB MCRS1 HNRNPA1 TOLLIP RPRD2 ZBTB17 EXOC8 NUP93 LRRC27 NDUFA11 CHCHD4 SIN3B BNIP3 SAYSD1 VMAC TMEM141 RPL27 EHMT1 PDRG1 DPF2 SUGP2 CSNK1A1 ANKRD24 LIPT2 VPS26B AP001372.2 YEATS4 GPI RNF19B CCDC12 GNB1L RPP38 POLD3 HINT1 TOMM20 STK32C IQCC VRK3 IRGQ FAM24B SLC2A11 CXorf38 SPRTN COPS7A POLA2 LARS2 RFX2 RANBP3 NCAPD3 PGS1 ZBTB40 CKLF-CMTM1 THAP7-AS1 WDR43 up
## KLF14_TARGET_GENES 0.0013717 0.0084544 0.5711369 2.722819 0 215 KCTD13 NOXA1 GTPBP3 AURKAIP1 EDC4 ANO8 MRPL4 FAM207A JMJD4 NAT9 KCTD5 RFXANK MRPS15 ADAM15 EARS2 UBE2Q1 ZNF205 SNAP47 MNT HAX1 VPS9D1 SLC39A3 AGK FAAH UCKL1 CDK5RAP3 RASA4CP TCF3 NLE1 CDK4 HMG20B KMT2D PRRG2 TLE6 PKM CCDC57 MAP2K2 GAS5 ARID1A PTOV1 SNHG7 UBFD1 ZNF408 SIRT6 POLE EN2 INO80B ZNF839 PISD TMEM104 EIF1AD MARK4 VPS51 SMG7 TJP3 HSPD1 SYT7 TAGLN2 NDUFS3 TRNAU1AP BANF1 C1orf74 RBM28 TOP3B CNDP2 ZNF276 NDUFS7 BRPF1 RTEL1 PTOV1-AS1 TNPO3 DRG2 LMX1B ZER1 SLC8A2 NR1H2 PTCD1 STOML1 NOSIP MFSD12 ZNF581 ARHGAP1 ANKRD24 PXMP2 FAM131A SMG8 ATP4A SMARCD2 SMG7-AS1 LINC00957 SEC13 HAUS8 NSFL1C C17orf75 CASZ1 MEGF8 PCIF1 UBE2H FAM83E PUF60 PI4KA TBC1D13 LINC00431 CATSPERG FCHO1 PAFAH2 RPS7 PLCH2 STX16 CPSF1 ENPP3 MRPL44 YIF1B EXD3 NR1H3 CELF3 FBXW8 ZMPSTE24 EIF2D GEMIN7 STX18 TPI1P2 NOP16 NMNAT1 RTEL1-TNFRSF6B AJUBA SNORA13 CCNE1 KCNN1 HIVEP3 DMAP1 ACP2 up
## ZNF711_TARGET_GENES 0.0010941 0.0084544 0.4973578 2.719117 0 1465 TBRG4 NUDCD3 PSMG3 SSU72 MLST8 MST1P2 MRPL55 EIF3B DUS1L MRPL24 FASTK ACBD6 DPP3 UBAP2L WDR24 TAF6 HLCS NOXA1 PYCR2 OGFOD3 SMG5 GTPBP3 PPP1R35 AURKAIP1 EDC4 PIGQ EEF1D SHARPIN TRAF7 SMARCA4 ZBTB45 TMED4 UBE2I MRPL4 TARS2 LGALS3BP ABCB8 FAM207A OTUB1 AP1S1 E2F4 POLD2 ZNF786 B4GALT7 SRCAP C1orf122 TRMT1 ZDHHC4 JMJD4 MANEAL SIL1 NPLOC4 ATIC TNRC18 BMS1 RCC1 KCTD5 MRPL33 ALG3 CTBP1 MRPS2 SH2B1 TSR3 USF1 ARHGEF11 RFXANK MRPS15 SLC2A4RG CDK5 PPP1R9A TUFM HDGF URGCP PDIA4 UBE2J2 CHD8 ZNF398 CCT6A UBE2Q1 DGCR8 ZNF205 C16orf58 TAF4 ZNF213 ECE2 MARK2 TSTA3 ZC3H3 SNHG3 SNORA14B JTB PRCC RPTOR TRMT2A STIP1 PPAN SRRM2 C1orf53 VPS72 ZNF12 ZGPAT MRPL12 AKAP1 SNORD60 FOXK2 SNAP47 GOLGA3 C12orf76 MTOR NT5C ZNF174 MGRN1 TMEM198 EIF4G1 TRUB2 CROCCP2 VPS9D1 RANBP1 COG4 LAS1L ZSCAN32 PIGG GAS8 GNPTG PSPH POLR2H IPO4 SCNM1 SLC27A5 GPR137 AGK SRRT SCAF1 UBE2C ZNF3 CDK13 BRD9 RNF187 AVL9 PSMD3 NDUFB2 SCYL1 USB1 FDPS DUSP28 EDF1 GEMIN4 TMEM62 PAXIP1 NCL SF3A2 ZNF32 GPN2 PI4KB CHCHD2 TMEM101 RUVBL1 BAD ZNF785 PLEKHA8 UBE3C PHLDA3 ZSCAN25 CDK4 INTS5 DDX55 USP42 PIH1D1 SNX8 IMP4 SPG7 PRRG2 TMEM9 TRMU TIGD1 KLC2 C9orf163 PLEKHJ1 UTP3 NMT1 TXNL4A GNAS CDK5RAP1 CLTA SUN1 MT-ND2 MRPL27 HMGXB3 CCDC57 MT-TP CRTC2 SF3B2 ARFRP1 MRPL21 CERS2 MAP2K2 NGDN PANK4 EIF2B4 SF3B3 DDX19A PHRF1 ZFP64 SEC61G PTOV1 DPH7 UPF1 SLC37A1 ZNF408 TSR1 SLC2A8 PSMD2 ING5 INO80B HDLBP ANKMY1 SRD5A3-AS1 SLC4A1AP MCM4 PARK7 CCDC47 HDAC3 STK35 RBBP5 CLK3 RNF4 CDK12 WDR73 SPIDR TACO1 IGHMBP2 MT-RNR1 MPHOSPH10 ERV3-1 ZNF319 EIF1AD SS18L1 LSM5 USP54 NKAP ELMOD3 CHCHD3 BCKDK COG1 ZNF628 IQGAP3 ZC3H4 MARK4 RPL37 NUP107 SNX19 CREBZF TARBP2 COPS7B CHPF NCOA5 TMEM79 SUPT16H KIAA0895 MNAT1 CCT2 VPS51 DDX19B TMEM203 ILF2 ZXDC PSMG3-AS1 MAP3K10 COA6 RN7SL1 RHBDD3 SMG7 HSPA9 TMEM214 GTPBP10 TRIM52 ACSF3 SNORD46 CWC25 DNAJC2 TBC1D16 C1QBP PSMA7 HSPD1 PSMC6 TAF12 WWP2 DHRS7 RAD23B CIZ1 GART C1orf43 ATP9A DNPEP ATG2A BANF1 RHNO1 POU3F2 MRPL48 DVL3 LSG1 STOML2 LTBR ZKSCAN2 SLC7A6 WDR83 TAPT1-AS1 RPL12 ZNF496 COA3 TMEM248 CPSF7 METTL16 SLTM ZNF862 RCCD1 PAIP1 FAM3A NOL12 MGME1 ZC3HC1 TAF7 SLC5A6 STK16 CPNE1 RELL2 PRDM15 HNRNPUL1 CDCA7 TSPAN31 AGPAT3 EXOC8 RBM28 ZNF579 TOP3B YTHDF2 MRS2 ZNF276 SNRNP70 EIF5B MARC1 SRRM1 LRRC27 NME1 NDUFS7 EEFSEC NME1-NME2 CBX1 KLHDC2 NUBP1 SNRPB FOXM1 PROCA1 PDCL3 DHX30 TOM1 COQ4 COQ9 RBM41 RTEL1 ANKRD13D RPL37A DMTN ZMYND8 RRM2 TUT1 RFX1 MRPS16 MON1A CYP51A1 TMEM41A RNF167 MCM3AP ACO2 MKRN3 LRSAM1 TCERG1 ZNF362 KHNYN SZRD1 HIRA TRIP4 NAIF1 PDE4A WDR45B BRD4 PTOV1-AS1 THAP3 TNPO3 PABPN1 HEMK1 RPS5 TP53TG1 BCL2L1 GTF3C5 GOLGB1 RPS27 ZNF714 DRG2 MT-TM SSBP1 TXN2 ANKRD39 AKT1S1 ETFA ZER1 RPLP2 MUL1 SCLY RPL27A PEX13 SF3A3 PSMC2 ZNF689 FBXO42 ATP13A4 NR1H2 ANKRD11 TSPAN10 PTRHD1 TMEM209 MAML1 PSMF1 TULP3 NOSIP RBAK MAN2C1 MAF1 RPL22 ZNF544 IFT57 RFWD3 TCF25 COX17 DTD1 FAM120A ZNF581 SLC22A5 EPS8 PPCS MBIP GRSF1 GSK3A TIMM9 NCSTN CIAPIN1 DHX33 SAE1 ARHGAP1 RNF10 RILPL1 NAPEPLD TM9SF1 FN3K PPCDC SH3YL1 TESK1 SMG8 YBEY NDUFC1 RPL3 SMARCD2 KDELR1 LIPT2 PHF5A ARID4B SMG7-AS1 RETSAT RANBP17 MED15 AP001372.2 FAM120AOS HUS1 RPS11 SNHG16 GPLD1 DNAJB12 XRRA1 SURF4 H6PD BRF1 NOL9 DNMT3A DHX9 SLC25A11 PCGF3 SNX27 ZNF774 PPP4R1 TSSC4 ZFAS1 SEC13 DENND6B CAND1 PEG10 ZNF592 RBM33 RNF19A ANLN TGFBRAP1 RPP38 ZNF580 POLD3 C8orf33 ERI3 BOD1 NSFL1C GPD1L RPL14 C17orf75 VHL NSD1 GOSR1 NOA1 MAU2 TOMM20 MT-TF ARFGEF2 TMCO1 MTX2 NT5M LEMD2 TIGD6 HSPA4 MPLKIP PRPF4 FRS2 C11orf49 SEMA4C ERI2 ATP6V1E2 SUGP1 CBLN3 MVK POLG AKAP9 ITFG2 ZNF346 SNAPIN PUF60 DCAKD PPP2R5B ZNF165 DCLRE1A ZBTB7A RPL29 FH NDUFAF3 ARHGDIA GGPS1 KLHL20 CCDC97 MADCAM1 NUP214 EIF2AK4 HECTD1 RPL32 ARMC10 NRBP1 TMCC1 B4GALT5 UCHL5 RRP15 SNRPD1 CA13 LINC01023 CELF1 TARDBP MBTPS1 DIS3L ANKRD46 ZNF446 USP40 MORN4 SPRTN CDC5L CCDC88B ZNFX1 SDHAF2 CDIP1 VCP FXN SFSWAP ABR HSPA8 NUP133 RINT1 PTCD3 ANKFY1 SRRM2-AS1 SMARCAL1 PDXK ESF1 THNSL2 RPS7 ABCC11 SLC25A51 GOLGA1 MTR ZNF146 NUDT18 LARP1B CCAR2 TCTA COPB2 RPL9 RBM14 CLPX SLC35A3 CDC25A BCL9 CACYBP STX16 RPS6 OLA1 DALRD3 NRDE2 SAR1B RPL23A PHYKPL ZBTB8OS CCDC117 SLC33A1 DTNB COPZ1 LTV1 CASD1 TRMT61B PIGV CPSF1 KRT8P12 SNX5 WDR43 DRG1 NAE1 KNSTRN MRPL44 IPPK EXD3 NR1H3 PSMA3 TBC1D17 TSN SNRPG RBM14-RBM4 EIF4E2 SDHC ZMPSTE24 SUPT7L ZNF354B TUBGCP5 NAA60 EIF2D KCTD18 PARP16 GEMIN7 NCOA7 STX18 TPI1P2 TSEN15 ENOX2 OFD1 ORC5 PPM1A up
## SETD1A_TARGET_GENES 0.0011198 0.0084544 0.4999747 2.715400 0 1272 TBRG4 NUDCD3 SLC4A2 SSU72 FLAD1 MLST8 ABCB9 TYW1 TBL3 NOP9 RCE1 FASTK NOC2L STAP2 OGFOD3 C7orf50 ATAD3A AURKAIP1 FARSA SHARPIN UBE2I MRPL4 DAP3 ZNF598 FBXL18 OTUB1 E2F4 KIF16B TXNDC17 RABEP2 SRCAP DIDO1 TRMT1 AK2 FOXRED1 USP18 NDUFS6 SIPA1L3 LONP1 NOL6 KCTD5 SH2B1 ZNHIT1 ZNF646 E4F1 RFXANK IWS1 DDX23 MRPS15 CRELD2 CDK5 NUDC GID8 TUFM TMEM222 HDGF UBE2J2 CHD8 GCDH C19orf48 SH3BP5L DDX41 TIMM44 SNHG3 EVI5L TRIM56 PRCC RPTOR TRMT2A SMPD4 PES1 EXOSC5 C1orf159 PDAP1 BECN1 SETD1A GOLGA3 DNAJC11 NELFA DDRGK1 FEM1A MZT2B MTOR CLPB DOHH NOM1 MRPL28 ACOT8 TRUB2 HAX1 RANBP1 COG4 LAS1L POLR2L KAT8 GAS8 SLC39A3 RERE GPS1 SDF2L1 PTGES2 SCNM1 GPR137 PNN SCAF1 ANKZF1 CDK13 ALG1 RECQL5 STK40 RANGAP1 HPS4 POLL SART1 GRWD1 PSMD3 TP73-AS1 ZDHHC12 PPP1R37 HMBS UCKL1 MUTYH NCDN ZSWIM3 FDPS MRPS33 SLC35B1 TRMT44 PI4KB CHCHD2 SUPT5H EXOSC6 SLC35E1 LMNB2 RSAD1 BAD DHPS RFNG TSFM TUBGCP6 PLEKHA8 DUS3L CCT5 PSMC4 TNPO2 FAM50B KIAA2013 IMP4 GRIPAP1 SETDB1 DPP9 ADPRHL2 TTBK1 GTF2F1 UTP3 PLOD3 NMT1 REXO1 NAV2 NUP205 CDK5RAP1 SNRPA NDUFS2 ZNF324B BSDC1 NOLC1 PPP1R8 PSKH1 CACTIN NDUFAB1 MRPL21 BAZ2A GAS5 DPH1 DDA1 ARID1A MRPL49 PSMC3 RNASEH1 SF3B3 DDX19A MRPL36 CCT7 ZNF408 IKZF4 PSMB5 INO80B ANKMY1 RMRP SLC4A1AP RRP1B CHCHD5 HS1BP3 CENPBD1 RBBP5 ENDOV ZNF384 XPO6 ZNF839 RNF220 EFTUD2 TACO1 IGHMBP2 MT-RNR1 PISD AMDHD2 MPDU1 EIF1AD POLR3A RPL36 LSM5 ELAC2 AMBRA1 BNIP1 ZNF414 DHRS1 SNAPC5 IDH3B METTL3 PHF23 RPL37 NUP107 GAR1 GGA1 COPS7B FIZ1 ZSWIM4 NCOA5 METTL2B SUPT16H SIRT3 TPR COA6 RHBDD3 SMG7 MAZ HSPA9 PHF14 GPR108 NFKBIB GTPBP10 CXXC1 SNORD46 MRPL51 MED9 YY1AP1 POLR2J3 MAPKAPK3 BAX CHMP4B PSMC6 HSD11B1L UBR4 ZNF787 MED18 ATG9A GART PSME3 GBA MSANTD4 MPV17 MCRS1 BANF1 RFX5 SLX4IP MAD2L1BP MRPS23 ALAD MRPL48 LSG1 TRIM62 WDR83 AARSD1 SPRED2 C19orf47 CPSF7 ASB16-AS1 HMGXB4 RPIA SAP30BP MAP3K11 IMP3 ANKRD54 STAMBP HEATR1 GLE1 SEC23B TSPAN31 AKAP8L RBM28 MICU1 LRRC41 CUL9 YTHDF2 CLASRP NUP93 RTF1 KIAA0319L PHB RBM12B RBM42 TMUB2 MRPS35 NDUFS7 E2F2 EEFSEC XPNPEP3 CS NUBP1 SNRPB RPS3 PPP1R12C MRPL2 SNRPC HIBADH GNL3 DUS2 PSMD13 DHX30 COG2 CDCA5 LYSMD1 COQ4 BRPF1 AAR2 PSMD11 PEX14 PNPT1 TUT1 RFX1 MRPS16 TMEM41A RNF167 SPAG7 SETD1B CREB3L4 TCERG1 NUP85 CYB5B SZRD1 TRIP4 STAG3L5P LANCL2 VGF BCL6 SHKBP1 SPAG4 ICAM5 RPS15 RPL24 PPP1R13L DRG2 RPL27 TRMT6 PARP2 SSBP1 ZNF219 TSR2 ZNF668 CUEDC2 TOMM22 RPLP2 RPL27A SF3A3 KIAA0753 RPS16 SCAF4 ZNF689 SURF2 TMEM183A ATP13A4 NR1H2 CES2 ECSIT DNAJC14 TOX4 NAGPA MED24 RPL41 MAN2C1 MAF1 RPL22 COX17 DTD1 NOP58 EPS8 RPL18 DHODH UBAP2 SP2 CCDC107 TIPIN RPL30 AFG3L1P SLC3A2 TIMM9 BUD31 IL23A AKT2 ARHGAP1 GEMIN5 RAB27A TIMM10 FKBP3 RPS28 SDHB PARS2 GBF1 TFAP2A FAU CDC42BPA TXNRD2 TMEM160 DSN1 NDUFC1 RPL3 ATXN7L2 PAN2 SMARCD2 FAM177A1 TPX2 PAK1 CISH CENPM SMG7-AS1 UQCRH MED15 AURKA TBCB DNAJB12 ALG12 RPS12 MDN1 ZNF524 SNRPF TCHP SLC25A11 KIF18B RTCB ZFP36L1 TIPRL SEC13 CCDC12 MEA1 TERF2 C8orf33 BOD1 DPCD HNRNPF MED26 MRPS27 KLHL7 MT-TF WDR89 PFDN4 ERI1 LEMD2 POLR2J4 DNAJB11 SNRPD3 SF1 UBXN1 MAPKBP1 POLR2I PGBD4 ERI2 MRFAP1L1 NUCB1 SLIRP ZSWIM8 KPNA6 ITFG2 PUF60 PPIL1 RPS10 DCAKD CCDC58 DCAF13 ZNF131 NUDT5 DCLRE1A ESPL1 RPL29 CCDC97 SPHK2 DLGAP4 CD3EAP RALGAPA1 ATP6V0D1 SLC7A1 UBC TTF2 TARDBP GUCD1 URM1 NFX1 TNK2-AS1 ERCC1 NCAPD2 MTCH1 HSF2BP YARS2 ZNHIT6 SNAPC2 RPN1 RPL26 LRPPRC SDHAF2 MIR320A ABHD12 HDAC1 COPS7A IFIH1 MCM8 SFSWAP TRMT5 SUCLG1 LARS2 NUP133 SNF8 KAT5 LINC00680 TMEM198B CEP350 PAFAH2 ESF1 GGNBP2 LMNB1 RPS7 ANKRD13A UQCRC2 ZFAND1 CENPL ZNF146 PUS3 CSTF1 CCT4 MRFAP1 CCAR2 GOT1 CLPX RHOF PIP4K2B STRIP1 C12orf43 SLC25A17 CAST ATR TADA3 FARS2 SAR1B ZBTB40 TAF1A HEXIM1 LRIG1 FAM162A LETMD1 MRPS28 TRMT61B CSNK2A1 ARID4A KRT8P12 ENPP3 CPD WDR43 CNOT2 RDH10 MRPL44 IPPK PSMA3 FKBP14 TSN SNRPG DHX32 ACOX3 ANAPC7 HARBI1 R3HCC1 SUPT7L NUP155 RPS15A TLN2 PSMD9 RPS27A up
## BARX1_TARGET_GENES 0.0011287 0.0084544 0.5024155 2.708801 0 1074 SLC4A2 FLAD1 EFNA4 MST1P2 MRPL24 SMG5 SHARPIN ZBTB45 TMED4 WDR55 GIPC1 TMEM134 GTF3C2 SLC50A1 FBXL18 POLM CCDC127 NUBP2 ZNF786 PIGO AIFM1 PSMD4 AK2 ITPA RNPEP ZNF672 IWS1 PSME2 MRPS15 CDK5 ABCF2 HDGF CBX8 PCGF1 GON4L ZNF398 FKBP2 RNF31 CCT6A EIF2B5 RNPS1 SYVN1 FAM220A ZNF48 EVI5L RNF181 PRCC EIF6 MAVS DOLPP1 SRRM2 CCT3 AP1M2 FAM71E1 LSM4 SETD1A SLC52A3 TRAPPC9 STARD10 MTOR ARL16 DOHH B4GALT3 HAX1 CROCCP2 TIMM50 TNKS1BP1 PSPH POLR2H SLC27A5 SRRT ENSA SCAF1 UBE2C AP4M1 CCDC124 CDK13 TDRKH EMC10 L3MBTL2 MST1 PSMD3 MOSPD3 NFATC2IP HAUS5 ZDHHC12 PPP1R37 ZNF444 DHX34 TMEM208 OS9 HGS NCL PMS2P4 RUVBL1 C1orf109 ZNF785 TUBGCP6 MVB12A ZFYVE27 MAN1B1 ISOC2 B3GALNT2 EFNA3 LRP10 KCTD21 BZW2 PRRG2 RAB11B FIBP RNU4-2 ELOF1 CDCA7L PUS1 AATF UTP3 HNRNPAB CDC37 TXNL4A ACP6 ADK SND1 XAB2 SUN1 MRPL27 ABCC10 DNMT1 BSDC1 KHSRP VPS18 ALDOA CACTIN CISD3 TMEM53 NIT2 CIT DCAF12 DDA1 TRA2A MRPL49 DUSP12 CHD4 RPUSD4 PPIL2 PSMC3 PHRF1 RABIF ILF3 PPP6R1 THRAP3 SAMD4B SLC37A1 METTL7B IKZF4 COPG1 SCAMP2 DIAPH1 SIRT6 TPCN1 UNC45A SDHA ABCA7 CD320 PARK7 ZNF514 STK35 MCM7 AAAS DCTPP1 MED8 CDK12 PISD THAP7 GPATCH2 POLR3A RPL36 ARFIP2 SZT2 BNIP1 RHOQP1 NR6A1 HIRIP3 SNAPC5 SAMD1 IQGAP3 ADAMTSL5 TYK2 PHF23 ZC3H4 GAR1 GSPT1 ZSWIM4 TMEM79 METTL2B SUPT16H AREG MARS2 DPM3 ILF2 CDCA8 NFATC4 FAM47E-STBD1 RHBDD3 TAX1BP1 PLK1 GPR108 ZDHHC5 TJP3 HAUS4 POP1 ZWINT CCDC9 QPCTL TOMM40L TAF12 WWP2 HSD11B1L TAGLN2 NDUFS3 MED18 PCK2 GART HTT KAZALD1 INCENP EDC3 SLX4IP XRCC2 MPV17L2 IRF2BP1 CYTH2 TUBA1C TSACC FBXL12 PAK4 RPRD2 TUFT1 GATAD2A SPRED2 KRT8 SYMPK PSMB10 METTL16 ASB16-AS1 SPRYD4 ARPC5L USP35 ELL3 RPL35 KLHL26 TMED1 PWWP2A RNF123 IER5 GHDC R3HDM2 TSPAN31 COA1 EXOC8 STAG3L4 NFYA XPOT LRRC41 RBFA GRK6 UQCRQ ARF6 NUP93 CLPTM1 DDX46 TRAPPC6A CCDC134 TMUB2 GRHPR XPNPEP3 NDUFA11 RPAIN RPS3 PET100 AGAP2-AS1 DUS2 CDCA5 BRPF1 C12orf10 RRM2 POLR2A DCAF15 RFX1 ENC1 SPAG7 ZNF584 FUS UPP1 PDE4A VMAC TNPO3 PABPN1 BCL6 NUP62 EIF3D SNRPD2 PPP1R13L RPL27 RNH1 INO80E RAB11B-AS1 SSBP1 SHC1 TXN2 TOMM22 PITRM1 UVSSA TMEM102 PRR15L SRP54 RPN2 DNAJC14 DHX8 PIGM FITM2 KANSL3 CALR MXD3 TULP3 NOSIP RBAK JUP MAF1 FASTKD5 ZSCAN20 UBOX5 BLOC1S3 RAB3A SNRNP35 COX6C POC1A WDR74 SCYL3 SP2 MZF1 RPL30 ADIPOR1 PMF1 SAE1 ALKBH2 RBM15 GEMIN5 ANKRD24 TNFSF9 FAU RPS29 TMEM160 NDUFC1 CDC20 TPX2 CDIPT ARID4B VPS26B HJURP ANP32A TAF10 UQCRH MCTP2 YEATS4 DNAH2 AKR1A1 ZNF775 BRF1 UBALD2 CRYM-AS1 CKAP5 SPSB3 TIPRL TSSC4 UTP18 ERP29 KDM4B KIF18A CASZ1 NDUFB1 RPL13A ACLY NEK2 ATL2 FAM118B MMACHC UBE2H ZNF747 ZBTB41 MPLKIP MIRLET7I NXN CRELD1 S100A11 PRPF4 MAPKBP1 LGALS8 TXNDC12 MVK POLG KPNA6 ITFG2 ZNF860 ZNF131 DCLRE1A OPA3 NFE2L1 GGPS1 NEAT1 ALDH4A1 KLHL20 HECTD1 EXO1 BTF3 CD3EAP LGALS8-AS1 RN7SL521P ATP6V0D1 CENPN RRP15 LINC01023 TARDBP BUB1B MRPL15 CFLAR EME1 ERCC1 COL17A1 ZNF446 MRPL54 SYNGR4 SPRTN C9orf64 RAB4B MTMR12 LRPPRC MIR320A NDUFA4 CENPF EHF SFSWAP KCTD7 EEPD1 SUCLG1 LARS2 SRRM2-AS1 PIF1 MCTS1 TMEM198B CEP350 MCCC1 PSMD8 HDAC5 NDUFA2 AGL NCAPD3 MRPL43 MBOAT7 PGS1 LMAN2L RPS6 LINC00649 DNM1P35 ZBTB40 NUP88 GMNN OARD1 TAB1 UBN2 PEX5 RPUSD3 FBXO16 TMEM143 THAP7-AS1 TIPARP ALCAM SMG9 WDR43 RPL23 TMEM106C LRR1 CENPE NIF3L1 HARBI1 PROSER1 LRRC29 RPS8 ACTN4 TPI1P2 THBS4 TRIM37 RPL7L1P8 ZFPL1 ARAP1 IK SON UBL5 DEPDC1B TRIP10 NOP16 NASP BANP HNRNPL FBXO33 DUT NMNAT1 C17orf100 OASL SERP1 DLGAP5 POLR3D AP2B1 ZNF2 PRKAG1 CKS2 SLC25A42 PPOX C14orf119 KHDRBS1 NDC80 GINS1 DMAP1 FKBP11 KIF3B SLC39A6 up
## MCM2_TARGET_GENES 0.0014993 0.0084544 0.6577829 2.698753 0 76 FBXL19 NCLN DDX23 ABCF2 HDGF TRIM41 CIAO1 PRCC C1orf159 TRAPPC9 FEM1A CLPB PNKD RAB43 UCKL1 ARHGEF5 TSC22D4 AAMP CRTC2 FBXL19-AS1 PANK4 PHF12 PHF23 FAM13A GSPT1 VPS51 AHDC1 DFFA CHMP4B ORMDL3 CYB561D2 TUBA1C C19orf44 ACVR1 PHB PSMD11 NPRL2 STAU1 BRD7 GSK3A DBP TSSC4 BOD1 TMEM127 up
## YBX3_TARGET_GENES 0.0014577 0.0084544 0.5865488 2.695251 0 163 FLAD1 WDR24 SHARPIN ZBTB45 UBE2I TRMT1 ZNF687 TSR3 NOC4L EVI5L STIP1 HAGH YIPF2 COMMD4 DNAJC11 ACOT8 DDX51 ERAL1 LRCH4 GNPTG ALG1 RECQL5 ZSWIM3 NCAPH2 TRAF2 NDOR1 DDX55 CDK11B MIR4479 NPM3 FAHD1 MRPL9 NGDN LMF2 SSNA1 FAM222B SLC4A1AP RNU5A-1 IDH3B PIGT COPS7B TMEM203 ANKRD16 HSPA9 ANAPC2 NDUFS3 OAZ3 ZNF830 CIC WDR83 ZC3HC1 SAP30BP PDHA1 AKAP8L RBM42 DUS2 FBXO24 SPAG7 NAIF1 GTF3C5 PEX13 CTSA NAGPA MED24 MAF1 SP2 SMG8 UQCC1 DBP GPATCH3 up
## KLF13_TARGET_GENES 0.0010672 0.0084544 0.4892167 2.693132 0 1766 PSMG3 SLC4A2 MRPS34 NOP9 TELO2 MRPL55 INPPL1 CBX4 SAMD10 SMIM1 TOP1MT ASL PUSL1 TAF6 C1orf35 NOXA1 PRPF6 SLC25A39 NIT1 ISG15 ATAD3A PPP1R35 AIMP2 CHID1 AXIN1 AURKAIP1 EDC4 FBXL19 ATAD3B IGSF9 EEF1D CCDC137 SMARCA4 OPLAH DLG3 TLCD1 UBE2I METRN LETM1 DHDDS TMEM134 FBXL8 ZNF598 AP3D1 CCDC127 ZNF696 ZNF629 KIF16B PEX10 RABEP2 SH2D3A SRCAP MORC2 CAPN15 BRAT1 JMJD4 LRRC45 MECR NPLOC4 NAT9 ATIC PARP1 TMEM150A SIPA1L3 PPP1R14B KCTD5 ZNF500 SH2B1 TSR3 ZNF646 SMYD5 PFDN2 SCAMP4 MFSD3 RFXANK PMS2 USP39 TFAP4 ARHGAP40 ABCF2 TUFM LRRC14 AGRN TMEM222 ZBTB42 DHCR7 ADAM15 GET4 WRAP73 SLC12A9 NDUFV1 APRT ANKS3 ZDHHC9 RUNDC1 EARS2 MAST1 TIGD5 UBE2Q1 DGCR8 GUSBP1 MARK2 CLDN6 ATXN2L EBNA1BP2 TSEN54 EVI5L HMGA1 SEMA4B FRMD5 TRMT2A ANAPC11 EIF6 SNHG11 TIMELESS NELFCD ACAP3 C1orf159 FOXO6 RRP1 HAGH EMC9 DUSP23 SNAP47 GOLGA3 DNAJC11 C12orf76 CLPB ZNF174 SNRNP200 SLC12A7 TMEM198 MNT HAX1 VPS9D1 RANBP1 ZNF239 TIMM50 DNAJC5 PPFIA3 ZSCAN32 SLC39A3 STUB1 GNPTG RHBDF1 CTU2 PELP1 IPO4 PTGES2 SCNM1 TXLNA AGK SCAF1 ZNF3 LSM14B AP4M1 PGBD2 BRD9 CACNB3 HPS4 WDR34 MST1 SART1 URB1 PPP1R37 VWA1 UCKL1 MUTYH ALYREF NCDN CDK5RAP3 RNF121 GPX4 SCYL1 GCC1 DHX34 ING2 TBX6 OS9 TRMT12 LSM7 GOLGA2 NCL SF3A2 EML2 MBD6 GPN2 TCF3 BPNT1 ILVBL RUVBL1 UBALD1 RAD23A NEK8 CBX3 NLE1 TUBGCP6 UBE3C MYL6B TRAF4 ROMO1 CDK4 EPS8L2 DDX54 HMG20B B3GALNT2 TMEM201 PTBP1 DDX55 EFNA3 MED16 AAGAB DCUN1D5 TSC22D4 KIAA2013 KCTD21 CCNF POLR3E PRRG2 PAFAH1B3 DPP9 MRPS6 CTNNB1 HES4 BCAT2 PTPN23 KLC2 C9orf163 PLEKHJ1 CHMP1A NMT1 CMTR1 TXNL4A NELFB ADK RAB24 GBAP1 PRMT1 FAM98C POLD1 ASPSCR1 FAHD1 ABCC10 ASNS BSDC1 KLF16 CHERP NOLC1 VPS18 B3GAT3 SLC35E2B DDX31 LIG3 PIP5KL1 ALDH18A1 MIDN MAP2K2 TMEM159 BAZ2A GAS5 DPH1 ARID1A ATAD2 NEURL4 DAZAP1 TRMT112 ITPKA KPTN PHRF1 ILF3 PPP6R1 HSPB1 WDR59 CSNK1D PTOV1 SNHG7 BPHL FZR1 CD46 THRAP3 JSRP1 SAMD4B UBFD1 C8orf82 COPS6 ZNF408 KDM3B PATZ1 TSR1 DIAPH1 SIRT6 NIPSNAP1 PIAS4 POLE ADAT3 SDHA PHF12 INO80B CARHSP1 ERGIC3 RRP1B CCDC47 ZNF76 ERGIC1 MCM7 RBBP5 ZNF384 CRLF1 CLK3 DGCR6L PRDX5 XPO6 SPATA33 ZNF839 CAPN10 SUPT6H WDR53 VAMP8 PISD TMEM104 PCNT MPHOSPH10 KRT18 EIF1AD SPPL2B RPL36 PNKP ZNRF2 MAD2L2 ZNF414 DHRS1 SNAPC5 SAMD1 BCKDK ZNF784 ZNF628 HPCA IQGAP3 ADAMTSL5 TYK2 TMEM52 FKBP4 GGA1 KEAP1 COPS7B GSPT1 CHPF GFPT1 METTL2B YWHAG SIRT3 PSMG3-AS1 MFSD9 FBXW5 ANKRD16 XYLB SMG7 HSPA9 PAK1IP1 PHF13 GALNT11 NFKBIB CUL7 GTPBP10 TJP3 ENO3 SGSM2 MKNK2 ACSF3 DFFA SNORD46 CENPT DNAJC2 ABHD4 MAPKAPK3 HSPD1 TOR4A CHMP4B SYT7 MAPK8IP3 METTL2A TMEM219 NDUFS3 ZNF787 RPL8 LINC00881 ZC3H18 CDHR1 DRAP1 CIZ1 C15orf39 GBA MCRS1 HTT ANKRD9 LTK BANF1 CCDC106 TP53BP1 EDC3 PTDSS2 SLC39A11 CSNK1G2 C8G ZNF354A ESYT2 HSPBP1 PRAME ALAD HNRNPU UNKL TUBB2A PPP1R26-AS1 TNIP2 LSG1 KMT2C CIC TUBA1C DHRS13 ADNP2 FBXL12 ZKSCAN2 PAK4 LRFN4 MIER2 TTLL11 NSUN4 WDYHV1 KRT8 CRTC1 CPSF7 PSMB10 SPRYD4 ZFP62 ARPC5L USP35 BTBD9 ACY1 RPL35 CA5BP1 MAP3K11 VAC14 OBSL1 HEATR1 HNRNPUL1 RNF123 PRKCZ URB2 R3HDM2 RBM28 MICU1 LRRC41 TOP3B PGPEP1 GRK6 ZNF276 CLASRP CLPTM1 KIAA0319L LRRC27 PDP2 NME1 UGDH EEFSEC NME1-NME2 NDUFA11 AUNIP C1QL1 EXPH5 LSM10 NUBP1 PSMD13 TAF6L PDCL3 CDCA5 LYSMD1 EEF2K BRPF1 VPS37B CHCHD4 FANCG MRPS16 SLC27A1 MON1A CYP51A1 TMEM41A TBC1D14 SIN3B SPAG7 RUNDC3A ARHGAP33 VPS25 HIRA TRIP4 VMAC MEF2D STAG3L5P VGF HEMK1 POLD4 TMEM191A NUP62 RPS15 CASP6 PPP1R13L ZSCAN31 SFT2D2 RNH1 TMEM182 GPRC5C STX4 ZNF668 AKT1S1 PPARD TTC39A SWI5 ZNF497 ZER1 MSTO1 AACS C11orf24 SLC8A2 TMEM102 SF3A3 S100A14 CLNS1A PSMC2 CLTB KCNH2 ZNF689 ANKRD36C LIG1 ATP13A4 LMNA NR1H2 CES2 SRP54 CTSA TSPAN10 PSMF1 PIGM STOML1 KANSL3 ECH1 PPP1R3D CALR MXD3 NOSIP RPL22 ZNF335 CNNM3 MFSD12 DTD1 ASPH CGB7 SUGP2 ZNF581 TOR1B TNFRSF21 PPAT RHOBTB3 AGO2 POC1A CCDC107 TIPIN CLCNKB GSK3A MAN2A2 HSD17B6 RNU5B-1 TIGD2 PRKAR1B TAF5L C16orf46 ARHGAP1 NAPEPLD RND2 ANKRD24 PXMP2 FAM131A TESK1 ATP4A APLP2 CISH COX7C AMPD2 FGD6 RAD54L SMG7-AS1 SFXN4 UQCRH AHCYL1 SLC35F2 GLDC PMEPA1 HUS1 PRELID1 SCAP TBCB GRIN1 SURF4 RNF145 TTC13 ZNF775 H6PD RRN3 NOL9 CTNS BCL7C SLC52A2 BYSL CCNB1 SNX27 TIPRL ZFAS1 SEC13 CYP2E1 HAUS8 PLIN3 MLXIP ZNRF3 ANLN GNB1L RAD9A TERF2 RNU6-9 UTP18 BOD1 BAIAP2 HNRNPF NSFL1C C17orf75 NDUFAF6 MEGF8 STK32C ADCK5 HNRNPA2B1 NEK2 NR1D1 PFDN4 FASN MMACHC ERI1 JRKL UBE2H LEMD2 PHKA2 MPLKIP CDC42SE1 MORF4L2 GGCX UBE2L3 NXN POLR2I KLHL36 MAP3K6 TXNDC12 APC2 MTG1 MND1 KDM6B CHAC1 LRRC37A3 PUF60 MAP2K1 ISOC1 PEF1 AKAP8 DCAKD DCAF13 CHCHD6 VRK3 CSK CHGB PI4KA RHEB ELK1 CCDC97 MADCAM1 CHKA USP20 PDIK1L ZYG11A CD3EAP VEZT CREB3L1 UCHL5 ATP6V0D1 CENPN RRP15 CELF1 BUB1B EZH2 TMEM125 CTBP2 LASP1 TBC1D13 ANKRD46 MTCH1 TBCD HSF2BP HMGCL PLIN5 SUMO3 TGS1 SCAPER C9orf64 PIEZO1 LINC00896 ZNFX1 MTMR12 SDHAF2 CKAP2L MTFR1L SDF2 CATSPERG HDAC1 CENPF VPS28 ETV3 C1QL4 IZUMO4 TNNI3 ACADS OST4 LARS2 SIX5 SMARCAL1 SMPD2 PDXK SMG1 PAFAH2 PFKFB3 PPM1J LMNB1 RPS7 USP10 ACOT7 LINC00115 ARHGEF18 CCAR2 PARP12 ZC3H11A RALGDS FBXO45 CLPX CECR2 WRAP53 ARV1 CDC25A MBOAT7 BCL9 SPRED1 PLCH2 SLC35F5 STX16 LYAR TADA3 G0S2 DNAJC1 RPL23A ZBTB40 COX10 LUC7L MED20 HEXIM1 TRMT61B GTF3C4 GLOD4 ULBP1 UBA52 ENPP3 TIPARP NDUFA10 SLC9A1 CIRBP SEC11C WDR43 CIB2 RPL23 CITED2 NAE1 MAPK1IP1L FRS3 FOSL1 KNSTRN EXD3 PELI2 CELF3 TBC1D17 FBXW8 TSN ASB1 up
## HOXA1_TARGET_GENES 0.0011287 0.0084544 0.4993692 2.685034 0 1005 TBRG4 FLAD1 ZNF692 C1orf226 RRNAD1 MRPS34 TBL3 GPATCH4 NOP9 EIF3B MRPL24 C16orf91 PRPF6 PYCR2 SMG5 C7orf50 ATAD3A AIMP2 FADD TMUB1 IGSF9 SMARCA4 UBE2I MTG2 TARS2 TRPT1 DHDDS DAP3 NUDT22 FBXL18 AP3D1 SPINT1 CCDC127 NUBP2 PIGO METTL1 CTTN RPPH1 ITPA LONP1 PMS2 WDR18 LARP1 ABCF2 ISG20L2 TMEM222 HDGF TM9SF4 CCDC86 BLOC1S4 NDUFV1 RNPS1 FAM220A TIMM44 PFAS SEMA4B PRCC TRMT2A SMPD4 NPRL3 NOB1 ENO1 MALSU1 PPAN BECN1 ATG16L1 ADRM1 SLC52A3 C12orf76 CDK2AP2 MZT2B STARD10 THAP4 ZNF174 MFN2 TMEM175 FDXR TRUB2 PICK1 HAX1 MYPOP RANBP1 ZSCAN32 PIGG SLC27A5 TXLNA BRMS1 ENSA HARS2 SCAF1 UBE2C MAP3K13 ZNF3 CDK13 RECQL5 STK40 RANGAP1 CXorf56 HAUS5 ZDHHC12 ZNF444 NCDN GCC1 TMEM208 NSUN2 SF3A2 NAT10 GPN2 RPS6KB2 C1orf109 NOP56 RAD23A ZNHIT2 TUBGCP6 TRAF4 AP5Z1 MAN1B1 NDOR1 MET TNPO2 MSRB1 B3GALNT2 DDX55 CDK11B RAB11FIP3 PIH1D1 SFN CCDC130 SNX8 SETDB1 CPSF4 PLEKHJ1 PUS1 FAF2 NMT1 CMTR1 ACP6 PCCB RUVBL2 FIGNL1 GORASP2 XAB2 CDK5RAP1 DNAJC16 KHSRP ERCC2 VPS18 CACTIN COX19 ALDH18A1 GYS1 NGDN MRPL49 CD55 NEURL4 LINC00857 ADAT1 KPTN ADAP1 MRPL36 THRAP3 CCT7 SAMD4B RAVER1 FTSJ3 FAM222B TSR1 DIAPH1 SIRT6 TPCN1 SDHA PHF12 HDLBP CD320 SLC4A1AP RBBP5 ENDOV DCTPP1 PDXDC1 NXT1 VAMP8 THAP7 LSM5 ARFIP2 HIRIP3 DHRS1 SNAPC5 IDH3B CHCHD3 FXR2 UBAP1 METTL3 TYK2 TMEM52 SRRM5 FAM13A MIS18A TMEM79 SUPT16H KIAA0895 CCT2 VPS51 TMEM203 ILF2 EFNA1 CDCA8 RN7SL1 FBXW9 NFKBIB TMEM214 GTPBP10 SRP68 CXXC1 SGSM2 PARP9 ZNF425 SNORD46 CENPT CWC25 YY1AP1 SRA1 HSPD1 CHMP4B TAF12 NDUFS3 LRRC59 RAD23B MED18 PSME3 CLDN12 NBPF3 TP53BP1 RPL13 ZNF26 KCNK5 ZNF830 KLHDC4 ALAD MTHFSD XRCC1 CIC PSMC5 NSUN4 COA3 PAIP1 TOP1 SAP30BP MYO10 CPNE1 MAP3K11 RNF216 PDCD2L C1orf74 DTX3L WDR60 SEC23B KIAA0319L PHB RBM42 LRRC27 XPNPEP3 CBX1 FAF1 RPS3 PET100 MRPL2 RPS6KA1 DUS2 TOM1 COQ4 MRPL38 SPATA2 ATG4B ZNF217 APTX ZNF584 SLC39A1 CREB3L4 UPP1 TRIP4 CDK11A KCTD2 PABPN1 SEC61A1 CASP9 RPL24 PARP2 INO80E GPRC5C SHC1 ZNF497 TOMM22 SAC3D1 TTC1 ASAH2B ERCC3 COPA ATP13A4 PTCD1 ECSIT MRPS21 TRIM47 PTRHD1 ARMC5 DNAJC14 PSMF1 RPL28 CCDC150 MAN2C1 TCF25 COX17 ZNF581 EPS8 WDR74 SRD5A1 RPSA SLC25A16 NCSTN AIMP1 ALKBH2 RAB27A ANKRD24 RPS28 PARS2 GBF1 SH3YL1 FAU SMG8 RPS29 COX7C THAP11 AP001372.2 DNAH2 TBCB DNAJB12 GAK TTC13 SPSB3 PINX1 TM4SF1-AS1 DENND6B CCDC12 ANLN TFIP11 ZNF580 POLD3 ZNF133 MRPS17 HUWE1 BOD1 KDM4B TMEM216 STK32C ACLY MRPS27 KLHL7 WDR89 RMDN3 MMACHC SF3B5 SUPT3H DNAJB11 SNRPD3 MORF4L2 GGCX UQCR11 FRS2 POLR2I PGBD4 DHX29 ERI2 MTG1 RAB1B MVK POLG DCAKD PPP2R5B ESPL1 CTDP1 IRGQ NEAT1 ZNF317 NUP214 FAM24B ZNF324 MIR4258 USP20 THEM4 RRP15 FAM122C GUCD1 NFX1 UQCRC1 MORN4 SYNGR4 ZNHIT6 RPN1 UBE4A SFSWAP SRSF9 SAFB PDSS2 SNF8 SIX5 TMEM198B ESF1 CFDP1 KIF3A PSMD8 LMNB1 NIPA1 GOLGA1 UQCRC2 RFX2 NDUFA2 CCT4 RANBP3 CCAR2 PARP12 TRIB1 TMEM115 ARV1 ZNF79 PGS1 RPS6 FOPNL NEDD4L PDCD7 CKLF-CMTM1 LTV1 REEP4 UBN2 TRMT61B GLOD4 TMEM143 THAP7-AS1 ENPP3 TIPARP SMG9 SEC11C RPL23 HOMER1 NAE1 ALDH3A2 ZNF200 ZNF821 TSN ACOX3 ZMPSTE24 NACA MAGOH SUPT7L NUP155 RPS15A MAP2K3 GTF2E1 GZF1 LRRC29 RPS8 PPM1A PANK2 NUBPL MKS1 ARAP1 IK RBM12 UTP15 HNRNPL TRAM1 ATP6V0E1 SYAP1 DUT F2RL1 up
## GGAANCGGAANY_UNKNOWN 0.0014706 0.0084544 0.6244310 2.685008 0 103 FARSA SMUG1 E2F4 BMS1 EBNA1BP2 ZNF48 PDAP1 SEC24C RNF25 MRPS18A DDX55 RUVBL2 STK36 EPN1 MRPL21 GYS1 SNRPE SEC61G RPL38 ZNF384 U2AF2 MED8 SUPT6H IGHMBP2 PEX6 EIF1AD SZT2 CHMP2A PSMB4 GGA1 DLX4 PCED1A ZDHHC5 ZNF513 BANF1 MRPS23 VPS16 COX6B1 CLASRP SEC61A1 SRP54 MRPS21 RPL28 TFB2M BUD31 TAF10 MBD1 TMCO1 PRKAB1 XIAP UBXN1 MTF1 SDF2 EIF3H SNIP1 UGGT1 MRPL43 PGS1 MTA2 UBA52 CCDC71 MOCS3 UBL5 FBXO38 TRMT11 EIF3K GLRX5 NCBP2 ZNF597 up
## ASH1L_TARGET_GENES 0.0011136 0.0084544 0.4937687 2.679197 0 1202 RHPN1 SNRNP25 FLAD1 COASY MRPL24 POLR3K STAP2 PYCR2 GTPBP3 C7orf50 FBXL19 EEF1D SHARPIN CCDC137 TRIM11 UBE2I GIPC1 TARS2 CABIN1 PGP REEP6 DAP3 UBQLN4 RHPN1-AS1 ABCB8 PMVK SMUG1 NUBP2 CA11 ZNF687 PSMD4 GGCT LRRC45 AK2 NOL6 NDUFS8 TMEM161A PC LYPLA2 DPH2 DDX23 P4HB DHCR7 CBX8 SAPCD2 TM9SF4 PDIA4 ZDHHC9 TIGD5 RRP9 UBE2Q1 HRAS TBC1D10B OXLD1 ATXN2L EVI5L RNF181 ROGDI TK1 STK11 STIP1 NOP14 TPRN DOLPP1 CCT3 HAGH LSM4 LMAN2 EMC9 FOXK2 GOLGA3 DNAJC11 FEM1A CDK2AP2 MTOR CLPB FEN1 PCSK4 ARL16 PDXP DOHH MGRN1 ACOT8 CCNL2 NPHP4 PACSIN2 LRCH4 DGAT2 LAMTOR2 SLC39A3 RERE PNN ENSA ANKZF1 TDRKH STK40 PNKD MOSPD3 NFATC2IP RRBP1 F11R MPND NCDN RNF121 ZSWIM3 CYHR1 FDPS TMEM208 EDF1 PAXIP1 HGS EML2 MBD6 TRAF2 CHCHD2 CDK16 RUVBL1 C1orf109 RASSF7 PARP3 ZNF785 HSPA5 CBX3 CHAF1A PLEKHA8 PSAT1 BAHD1 ISOC2 TNPO2 PRR14 MAEA CBY1 CCDC159 DDX54 PTBP1 PHPT1 CDK11B AAGAB CCDC130 CCNF MIR4479 PASK GRIPAP1 SPG7 PRRG2 ZSWIM1 RAB11B AAMP WDR62 CDCA7L HNRNPAB LAMTOR4 GBAP1 PRMT1 TLE6 XAB2 TMEM45B SUN1 TOMM40 MRPL27 FAHD1 HINT2 KHSRP ERCC2 POLR1A CRTC2 THAP8 TMEM53 CIT CHEK2 NGDN DDA1 PAXIP1-AS1 SNRPE PPIA ZNF526 PHRF1 ILF3 GNB2 CCT7 FTSJ3 FAM222B SCAMP2 PSMA5 SLC2A8 ABCA7 NABP2 PHF12 ZNF622 ACBD4 RPL38 TBC1D22B STK35 ZNF384 ZBTB18 CLK3 MPRIP MED8 CDK12 PDXDC1 DROSHA BLZF1 PCNT ERV3-1 ELAC2 SZT2 NR6A1 ADAMTSL5 TYK2 DDIT3 BABAM1 COPS7B GSPT1 ZSWIM4 DDX19B ILF2 ANKRD16 CDCA8 TPD52L2 RHBDD3 CTPS1 WDR6 GPR108 ZDHHC5 NFKBIB MRPL37 CCDC61 YY1AP1 ZWINT KIAA0895L CHMP4B TOMM40L NDUFS3 DDOST ZKSCAN5 ATG9A MSANTD4 MVD HNRNPA1 ADPRHL1 ZNF691 MLEC INCENP TP53BP1 ZDHHC16 MPV17L2 PNPO ZNF688 CYTH2 CIC TSACC AEN WDR83 MRPS12 PSMC5 GATAD2A TRAFD1 TMEM248 DDX49 FAM227A ANKRD54 PWWP2A HNRNPUL1 CDCA7 TSPAN31 AKAP8L NFYA ZNF117 LRRC41 YIF1A DEF8 MTRR COX6B1 KIAA0319L ZNF574 PHB TRAPPC6A RBM42 DHX38 PDP2 EEFSEC PAF1 PET100 SUCO PSMB3 ORMDL2 FBXO24 ZMYND8 PIN1 DCAF15 RFX1 WDTC1 TIMM8B GTPBP1 RNF167 SPAG7 GATAD2B SLC39A1 FUS CREB3L4 PDIA6 ACO2 TCERG1 CYB5B HIRA NAIF1 NDUFAF2 CDK11A KCTD2 TNPO3 PABPN1 LANCL2 PGAP2 BCL2L1 BCL6 SHKBP1 COPE GOLGB1 NF2 PPP1R13L ZNF714 RAB11B-AS1 SHC1 STX4 WDR25 DCAF11 ANKRD39 MSTO1 TMEM205 RPL19 NARF SNRNP40 RAB40B ZNF689 ALKBH7 ANKRD11 AHCYL2 MED24 CALR TULP3 TSPAN15 NOSIP STAG3L3 JUP MAF1 ZNF107 CNNM3 ZSCAN20 MFSD12 RFWD3 TMEM258 PPP2R5E BLOC1S3 RAB3A LCMT1 TRIM68 RPL18A SCYL3 SP2 STK11IP RSBN1L RNF26 GNA12 HOMEZ MED29 IL23A PMF1 ZNF837 FCF1P8 CLUHP3 FNBP4 GBF1 SAP130 DDX39A TMEM160 PAN2 TPX2 PHF5A CDIPT COX7C ARID4B FGD6 HJURP RAD54L ANP32A CENPM C19orf81 UQCRH ZNF77 SLC35F2 RAB3D EXOSC1 RPS11 AURKA AHSA1 TBCB FKBP8 KATNB1 ZNF775 SNRPF BAIAP3 CCNB1 UBALD2 UFC1 SLC25A11 MCM3 CKAP5 KIF18B SPSB3 ZNF726 ZNF774 CHRNB1 RNFT2 HAUS8 GLCCI1 FASTKD3 ZNF133 UTP18 ERI3 NIPAL3 BOD1 KDM4B NSFL1C MTMR4 INPP5B NSUN5 NDUFB1 MAU2 PTMA KPNB1 HNRNPA2B1 BUB1 WDR89 PFDN4 MMACHC SPC24 STT3A POLR2I GLO1 ERI2 APC2 SUGP1 CDR2 MVK POLG AGBL5 CNPY3 AKAP8 ZNF138 CHCHD6 MDM1 BRIP1 KIF1B GGPS1 CCNK ALDH4A1 ZNF317 RPL32 MED19 ARVCF CD3EAP AP2A1 VEZT CENPN METTL17 UBC TTF2 EXOC4 INTS4 MAGI3 TARDBP EZH2 FDFT1 EME1 LINC00431 MTCH1 NCOA2 MORN4 BRCA1 CCZ1 RAB4B MTMR12 LRPPRC C12orf49 CKAP2L VCP BPGM SNX12 FCHO1 CENPF NRL KCTD7 HSPA8 GOLPH3L PTCD3 ANKFY1 UROS PIF1 MPZL1 CEP164 NUP62CL RPS7 HMMR MTR UQCRC2 RFX2 NDUFA2 CSTF1 DHCR24 DAPK3 WDR81 POLR1D TMEM115 GOT1 WRAP53 STRIP1 CCNB1IP1 LLPH KLHDC9 MCM5 ZNF100 TADA3 PRDM2 C1QTNF6 PER2 LNX2 COPZ1 OARD1 PQBP1 ARID4A CCZ1B ELMO2 EDEM3 DUSP10 ALKBH6 PPP1R7 TANGO2 CENPE FKBP14 TBC1D17 SFXN5 METTL23 FUT8 CYB5A TUBGCP5 NAA60 GTF2E1 PARP16 RPS27A RPS26 DCAF4 LRRC29 TPI1P2 C1orf216 AFMID PANK2 XRCC3 IK SARS2 FAM117A ZCCHC17 PXMP4 LEMD3 TRIP10 RHCE BANP HNRNPL FBXO33 CANX HLTF HMGN3 DLGAP5 RALGPS1 SPRYD3 E2F3 CKS2 SLC25A42 ABHD8 SNORA13 HINFP NAP1L4 TUBB4B CHD6 SAP30L-AS1 up
## BARHL1_TARGET_GENES 0.0011236 0.0084544 0.4951719 2.674313 0 1106 SLC4A2 ZNF692 NOP9 RCE1 COASY MRPL55 EIF3B NMRAL1 PRPF6 DNTTIP1 GTPBP3 C7orf50 PHKG2 FADD FBXL19 ATAD3B CD2BP2 TLCD1 MTG2 RHBG MRPL4 GDPGP1 GTF3C2 ABCB8 SLC50A1 FBXL18 ADAR WDR4 OTUB1 NUBP2 WFDC3 CA11 PIGO QTRT1 SRCAP ZNF212 ZNF687 ZBTB48 RPPH1 MECR LONP1 PPP1R14B RCC1 SH2B1 CDK5 ABCF2 LMTK2 TUFM DHCR7 HDGF ADAM15 GFER TM9SF4 USP21 CCDC86 TRIM41 ZNF398 BLOC1S4 NOC4L CCT6A SNHG12 RRP9 HRAS SH3BP5L ZNF213 RPL39L EBNA1BP2 ZC3H3 PFAS SNHG3 TRIM56 NAA40 TRMT2A PPAN PRMT5 BECN1 PMS2CL SDC1 STARD10 NT5C MGRN1 FDXR DDX51 CRB3 MYPOP RANBP1 PIGG PSPH POLR2H SLC27A5 KLHL12 BRMS1 SCAF1 ESRP2 CCDC124 CDK13 RECQL5 STK40 RANGAP1 HPS4 L3MBTL2 WWC1 PNKD URB1 MOSPD3 HAUS5 NDUFB2 SNHG17 GUK1 NCDN SNHG15 ASB6 SLC35B1 PAXIP1 NCAPH2 GGA3 GPN2 RPS6KB2 TMEM101 C1orf109 POLR1C PARP3 NEK8 TUBGCP6 GNL2 PRKCSH YIPF3 PLEKHA8 MET MZT2A DDX55 CDK11B MIB2 LRP10 KCTD21 CCDC130 SNX8 IMP4 SLC16A13 GRIPAP1 SPG7 PAFAH1B3 RAB11B AAMP MACC1 RNU4-2 CDCA7L THTPA PON3 ACP6 ADK PCCB NUP205 CDK5RAP1 TOMM40 MRPL27 NUTF2 REG4 DNMT1 PKM KHSRP NOLC1 RUSC1 CLEC16A CACTIN TTI1 FAHD2A MRPL49 LMF2 RPUSD4 ADAT1 SNRPE HAGHL EIF2B4 RBM47 NTMT1 RNASEH1 KPTN RABIF ILF3 HMOX2 FBF1 FZR1 POLR2E MRPL36 THRAP3 RAVER1 SSNA1 FTSJ3 MRPS7 GCNT3 TMC5 NABP2 ZNF514 ENDOV ZNF384 LLGL2 ZMAT2 WDR53 NARS2 TXNDC11 USP54 ELAC2 LTBP3 HIRIP3 DHRS1 TMEM52 SRRM5 PIGT KIAA0895 SIRT3 TPR TPD52L2 LDB1 TAX1BP1 HSPA9 WDR6 ANAPC2 TRIM52 NIP7 DFFA SNORD46 CWC25 DNAJC2 TBC1D16 MAPKAPK3 CHMP4B NBR2 ORMDL3 TTPAL L3HYPDH SCAND1 MGST1 EPHB4 CCDC51 PSME3 MLEC INCENP ZDHHC16 CSRNP2 ZNF26 RHNO1 ZNF688 XRCC1 CYTH2 CYB561D2 WDR83 LRFN4 MRPS12 PSMC5 RPL12 COA3 TMEM248 ASB16-AS1 ZFP62 RCCD1 ARPC5L USP35 CORO2A TOP1 RPIA SAP30BP RPL35 CRAT MAP3K11 RNF216 PSMB6 XPOT NDUFV3 SEPHS2 KIAA0319L DDX46 RBM42 TMUB2 FOXM1 MTHFR MRPL2 HIBADH GNL3 PSMD13 TAF6L ITGA3 COG2 CDCA5 BRPF1 PIGU POLR2A NPRL2 MON1A APTX LRSAM1 SNHG8 CDK11A STAG3L5P HEMK1 RPL24 RPLP0 CASP6 FAM214A PARP2 INO80E RAB11B-AS1 SSBP1 MEPCE SHC1 TXN2 DCAF11 AKT1S1 ETFA CUEDC2 MUL1 TTC1 CLNS1A PSMC2 ASAH2B RPRD1B ZNF689 RPN2 ARFGAP2 PSMF1 TULP3 RPS20 EPS8 RPL18 RPL31 WDR74 UBAP2 MZF1 GSK3A STK11IP ZMAT5 CSNK1A1 SLC3A2 NOD1 EHBP1L1 DHX33 PMF1 SAE1 AIMP1 GEMIN5 RNF10 TOB2 FNBP4 FAN1 FAU TMEM160 AGR2 PPIH CISH RPA3 TAF10 SDR39U1 EXOSC1 YEATS4 SNHG16 AHSA1 DNAJB12 IRF6 MBD1 NUP188 ZNF394 MDN1 CRKL CCNB1 DVL2 KIF18B CYP4A22-AS1 SPSB3 PINX1 ZNF774 MIF4GD ZFAS1 ANLN TFIP11 COG8 SRSF1 BOD1 ERP29 RPL14 TOMM20 PTMA KPNB1 COX5B KLHL7 UQCR10 C12orf65 PCIF1 FAM118B MMACHC SUPT3H WDHD1 LRRC56 CRELD1 UBXN1 PRPF4 PGBD4 HM13 GANAB MVK POLG VRK3 NEMF RPL29 RHEB SERF2 IRGQ CCNK EML4 KIAA1958 SPHK2 NUP214 EIF2AK4 HECTD1 ARMC10 MIR4258 USP20 TMCC1 BTF3 AP2A1 RN7SL521P RRP15 UBC LINC01023 BUB1B EME1 DHX57 COL17A1 MORN4 PLS1 BRCA1 DHFR RNF7 ZNFX1 MLLT3 VPS28 BAP1 SFSWAP SRSF9 ALOXE3 KCTD7 EEPD1 TRMT5 LARS2 CEP350 CFDP1 KIF3A RPS7 ZNF252P SLC35E3 GOLGA1 ZFAND1 CENPL RFX2 NDUFA2 ARHGAP32 EID2 GOT1 FBXO45 CLPX RHOF PSD TP53RK POLDIP3 GMPPB SLC35F5 THNSL1 COX10 CLCN6 SLC33A1 COPZ1 HEXIM1 NAA38 ARID4A GLOD4 RNU12 FBXO16 HIGD2A SLC9A1 SEC11C ZFHX2 SERPINB5 TMEM144 MRPL44 FKBP14 TBC1D17 ZNF200 RILP METTL23 NIF3L1 MAGOH NUP155 RPS15A ZSCAN2 PROSER1 EIF2D JKAMP GZF1 RPS8 DOLK STX18 CETN3 TRIM37 NUBPL ZFPL1 ARAP1 IK SARS2 up
## DBP_TARGET_GENES 0.0011173 0.0084544 0.4877069 2.648138 0 1251 SLC4A2 EIF3B ACBD6 RER1 NMRAL1 TSPAN17 SMG5 AURKAIP1 CD2BP2 FARSA WDR55 MRPL4 TARS2 THOC6 SLC38A10 FBXL18 INTS1 WDR4 CEP85 NUBP2 AP1S1 MRPL20 SRCAP GGCT SIL1 ATIC LONP1 TNRC18 ZNF764 SH2B1 USF1 ZNF672 TYSND1 P4HB RNF207 CDK5 ABCF2 GUSB HDGF PIP4K2C PCGF1 USP21 SLC12A9 ZNF398 CCT6A C1orf174 EIF2B5 RNPS1 SH3BP5L RNF44 MAD1L1 PPM1G FAM220A RNU4-1 PRCC NOP2 STIP1 TIMELESS BCL2L12 TMEM184A C1orf159 ATG16L1 ZNF12 RAB19 GMPPA LMAN2 SETD1A NELFA FEM1A STARD10 CLPB THAP4 DOHH MGRN1 SNRNP200 TMEM198 CCNL2 TRUB2 PICK1 HAX1 ERAL1 LRCH4 MYPOP AHCY NUMA1 TIMM50 PPFIA3 PSPH KIF22 GPR137 IRF3 SRRT SCAF1 PITPNM1 ZNF3 CCDC124 BRD9 RECQL5 STK40 WDR34 L3MBTL2 SART1 PNKD PSMD3 STAT6 UQCC2 NDUFB2 PPP1R37 LINC00265 ZNF444 GPX4 GCC1 SNHG15 MRPS33 NSUN2 LSM7 SLC35B1 SF3A2 STK25 NAT10 SUPT5H RPS6KB2 TMEM101 ILVBL C1orf109 DHPS CBX3 MVB12A PRKCSH PLEKHA8 FBXO46 MAN1B1 CDK4 INTS5 DDX55 UBE2M SFN SNX8 NPM3 SPG7 DPP9 RAB11B AAMP PRPF19 BCAT2 PLEKHJ1 ACP6 ADK NUP205 CLTA TOLLIP-AS1 SNRPA NDUFS2 ASNS PMM2 ALDOA CACTIN MUC1 DDX31 TTI1 BAZ2A CHEK2 TMEM259 FIS1 CTU1 PPIL2 EIF2B4 PLAGL2 MED25 ILF3 HMOX2 SAMD4B ZNF408 FTSJ3 FAM222B TMEM186 DIAPH1 PSMB5 NDUFS5 C9orf16 NABP2 TLE3 PHF12 INO80B ZNF622 TBCC PPRC1 C19orf53 CENPBD1 RBBP5 ENDOV AAAS ZMAT2 CDK12 DROSHA WDR53 MPDU1 RPP25 RPL36 LSM5 EXOC7 PYGB NR6A1 CHD2 JOSD2 CHCHD3 UBAP1 METTL3 ZC3H4 KDM2A PA2G4 RPL37 NUP107 COPS7B GSPT1 CHPF ZSWIM4 EXOSC10 TMEM79 METTL2B KIAA0895 MYL5 CAMTA2 TPD52L2 XYLB MAZ HSPA9 PAK1IP1 GPR108 ZDHHC5 GTPBP10 CXXC1 HCFC1R1 NIP7 DFFA ZNF425 MRPL51 RNU5E-1 TOMM40L HSD11B1L ZKSCAN5 EPHB4 TRNAU1AP GART MPV17 MVD MCRS1 HNRNPA1 CAPN8 TPGS1 EGR4 SLX4IP ESYT2 RHNO1 GSTK1 PRR14L IRF2BP1 VPS41 ZNF688 TOLLIP TMEM147 RPRD2 SLC7A6 AARSD1 RAD50 MRPS12 PSMC5 TUFT1 RPL12 KRT8 COA3 SYMPK TMEM248 SLTM MUS81 TAF7 ELL3 SAP30BP MMP15 OGDH FBXL15 STAT2 MAP3K11 MORN1 HNRNPUL1 PSMB6 WDR60 AKAP8L COA1 RBM28 NDUFV3 C19orf44 GRK6 EIF5A ARF6 CLPTM1 RUFY1 PHB DHX38 NME1 CLN6 NME1-NME2 NDUFA11 EXPH5 PPP1R12C RPS6KA1 PDCL3 ITGA3 COQ4 FBXO24 VPS37B C12orf10 POLR2A ATG4B ENC1 RNF167 SPAG7 LRSAM1 UPP1 C1GALT1 SZRD1 TRIP4 VMAC LZTR1 TNPO3 HEMK1 TP53TG1 SEC61A1 BCL2L1 ZSCAN21 RPL24 RPS27 EIF3D DRG2 RPL27 RAB11B-AS1 ZNF219 AKT1S1 TOMM22 SAC3D1 TTC1 TMEM179B SF3A3 MRPL34 NLRX1 RPS16 RPRD1B ZNF689 ALKBH7 ECSIT ANKRD11 AHCYL2 DNAJC14 TOX4 ECH1 MED24 CTNNBIP1 MXD3 TULP3 METTL18 ACAA1 JUP RPL22 TFB2M LCMT1 RPL18 GRPEL1 ZMAT5 RSBN1L AFG3L1P SRD5A1 MRPS11 SAE1 ALKBH2 TMEM189 ARHGAP1 TIMM10 GBF1 NDUFC1 DBP CDIPT COX7C ZSCAN22 HJURP SDR39U1 CNPY2 SNHG16 AURKA AHSA1 KIF2C KATNB1 MBD1 NUP188 ZNF394 SMARCC1 SLC25A11 SPSB3 PELO TNFRSF1A CHRNB1 ZFAS1 RNFT2 CAND1 TAPBPL DDX12P RAD9A MEA1 COG8 SRSF1 MRPS17 HUWE1 BOD1 ERP29 GPD1L RPL14 RPS14 MEGF8 TWISTNB RPL13A HNRNPA2B1 MED26 KLHL7 UQCR10 MMACHC UBE2H LEMD2 BBC3 HSPA4 MPLKIP SF3B5 DNAJB11 SNRPD3 CDC42SE1 FAM83E SF1 TRAPPC6B HS3ST1 MAPKBP1 PGBD4 SF3A1 HM13 NUCB1 ITFG2 CHAC1 OCEL1 PPP2R5B CHCHD6 VRK3 NEMF CTDP1 SERF2 NDUFAF3 SPHK2 SWSAP1 MED19 GEMIN6 AP2A1 RN7SL521P UBC CELF1 INTS4 GUCD1 BUB1B C6orf62 FDFT1 DHX57 NCAPD2 GOLGA4 CFL1 YARS2 MORN4 TGS1 ATP10B ZNFX1 C12orf49 SCAMP5 UBE4A COPS7A VPS28 SFSWAP KCTD7 EEPD1 EIF3H OST4 SAFB PCNA IMMT TMEM198B CFDP1 PFKFB3 PSMD8 RPS7 TACC2 ANKRD13A OSBPL3 SLC25A51 CHTOP GOLGA1 RFX2 ZNF146 NDUFA2 CSTF1 CCAR2 COX8A TRIB1 GOT1 FBXO45 WRAP53 STRIP1 MBOAT7 C12orf43 ELL CCNB1IP1 LINC00511 PSD STX16 TADA3 WDR12 DALRD3 LINC00649 ZBTB40 NEDD4L UBLCP1 ZBTB8OS TAF1A RNU6-2 LETMD1 UBN2 GTF3C4 FBXO16 HIGD2A CPD KRIT1 SMG9 ZNF815P CITED2 HOMER1 TMEM106C FOSL1 SPATA24 IPPK HOXC5 PSMA3 TBC1D17 SFXN5 TSN NIF3L1 FUT8 ANAPC7 UBL7 NUP155 CYB5A NAA60 RPS27A RPS26 NCOA7 SIAH2 RNF20 DOLK TPI1P2 TRIM37 RPL7L1P8 ARAP1 IK SARS2 SON FAM117A CHEK1 SOD1 TRIP10 NOP16 ATF4 HOXB6 BANP HNRNPL ATP6V0E1 NIPA2 NMNAT1 KIF23 PLEKHG2 SP140L DEDD SERP1 ETV6 SAFB2 MAPKAPK5 SEC23IP MAP3K14 WSB2 C15orf61 FBXO38 CKS2 PPOX SNORA13 TRMT11 HINFP SAP30L-AS1 MRPL46 C14orf119 up
## MTA1_TARGET_GENES 0.0010672 0.0084544 0.4802877 2.643770 0 1760 TBRG4 ZBTB7B SSU72 RPAP1 RRNAD1 DNAJA3 CLPTM1L TBL3 HOOK2 GLYR1 NOP9 RCE1 MRPL55 CBX4 C16orf91 UTP14A PUSL1 C1orf35 UBN1 PRPF6 DNTTIP1 GTPBP3 ISG15 C7orf50 ATAD3A MGAT4B PIGQ FBXL19 ATAD3B ANO8 OPLAH UBE2I MTG2 MRPL4 LETM1 DHDDS TMEM134 FGFRL1 GTF3C2 UFSP1 LZTS3 FBXL18 ADAR WDR4 CEP85 NUBP2 ZNF629 WFDC3 PEX10 DBNDD1 NR2F6 RABEP2 MTX1 METTL1 CTTN FOXRED1 MECR RECQL4 LONP1 TNRC18 SH2B1 RNPEP ZNF646 E4F1 TTLL4 DDX23 TM7SF2 WDR18 LARP1 ABCF2 TUFM LRRC14 ISG20L2 DHCR7 URGCP WRAP73 TM9SF4 CCDC86 CIAO1 GCDH GCAT NDUFV1 NOC4L TRIP6 NME4 UBE2O C1orf174 C19orf48 RNPS1 PSEN2 UBE2Q1 ZNF213 TFR2 MAD1L1 ATXN2L TIMM44 ZC3H3 PFAS CAPN12 NAA40 SEMA4B TRMT2A NSMF SMPD4 PES1 TRAP1 CYC1 MALSU1 PPAN PARD6A ACAP3 PDAP1 RRP1 AUP1 BECN1 ZMYM3 ATG16L1 RPUSD2 FAHD2CP YIPF2 FOXK2 SETD1A TRAPPC9 NELFA SDC1 FEM1A C12orf76 CDK2AP2 MZT2B CLPB THAP4 TMEM63B MFN2 ENTPD6 TMEM175 FDXR FOXK1 TMEM198 DDX51 CCNL2 MNT VPS9D1 ACD RANBP1 EPN3 LAS1L DNAJC5 KAT8 PIGG GAS8 RHBDF1 CTU2 POLR2H PELP1 ZMIZ2 KLHL12 GPR137 BRMS1 SCAF1 PITPNM1 MAP3K13 CCDC124 TDRKH BRD9 CACNB3 RECQL5 RANGAP1 RNF187 HPS4 WDR34 CXorf56 GRWD1 RRBP1 ATXN7L3 ZNF444 GUK1 GCC1 TRMT61A FDPS TMEM208 SNHG15 NHP2 EDF1 DAGLA C2CD3 MRPS33 NSUN2 SLC35B1 TRMT44 NCAPH2 B4GALNT1 GGA3 EML2 NAT10 TRAF2 UMPS CHCHD2 RPS6KB2 TMC6 TCF3 DIS3L2 SLC35E1 C1orf109 ANKRD13B PPME1 ZNHIT2 CBX3 TSFM NVL TUBGCP6 FPGS MYL6B RNF216P1 NDOR1 ROMO1 TNPO2 PRR14 B3GALNT2 MZT2A DDX55 USP42 TSC22D4 MIB2 CCDC130 SNX8 POLR3E NPM3 SPG7 DPP9 RAB11B MACC1 FIBP ADPRHL2 HES4 C9orf163 LINC00853 LAMTOR4 CMTR1 ZNF778 HOXC13 GNAS NUP205 FAM98C XAB2 PPP4C MRPL11 HMGXB3 ASNS EPN1 PKM KHSRP NOLC1 CLEC16A CCDC57 VPS18 CMPK2 ZNF263 PSKH1 WIZ CRTC2 PARD3 DTYMK MRPL9 CACTIN MUC1 SF3B2 DDX31 TTI1 ALDH18A1 FAHD2A ANKRD13C CHKB NGDN MCCC2 ATAD2 MRPL49 LMF2 CD55 HSH2D HTATSF1 DAZAP1 ADAT1 NCOR2 NTMT1 RNASEH1 KPTN SGTA ADAP1 DDX19A ILF3 PTOV1 SNHG7 MRPL36 THRAP3 SSNA1 FOXA1 ANGPTL4 C9orf16 MRPS7 PRSS16 ABCA7 ING5 PPP6R2 SLC4A1AP RRP1B ACAD9 RPS2 PARK7 C19orf53 ZNF514 CENPBD1 SPINT2 ENDOV ZNF384 TIMM13 ZNF839 CAPN10 EFTUD2 WDR53 UCA1 PCNT KRT18 EIF1AD THAP7 RPL36 PNKP USP54 ARFIP2 MAD2L2 NR6A1 FGF13 DHRS1 JOSD2 SNAPC5 IDH3B BCKDK ZNF628 ADAMTSL5 TYK2 ZC3H4 APOBEC3B MARK4 SRRM5 PIGT PRKCA GAR1 BABAM1 LINC00630 FAM122B TARBP2 ZNF274 COPS7B CHPF RNF43 MSL3P1 TTC22 DDX19B TPR TMEM203 MAP3K10 TPD52L2 XYLB HSPA9 GALNT11 ANAPC2 CARM1 FBXW9 NFKBIB CUL7 TICAM1 TMEM214 GTPBP10 TJP3 TRIM52 CLCF1 NRSN2 MED9 LMLN MSL1 HSPD1 CHMP4B NBR2 SYT7 ORMDL3 HSD11B1L UBR4 TAGLN2 NDUFS3 RPL8 P4HTM ZKSCAN5 ZC3H18 CIZ1 PSME3 GBA BANF1 CAPN8 CCDC106 ERBB3 RFX5 EDC3 OAZ3 ZNF26 XRCC2 ESYT2 KCNK5 HSPBP1 PPP1CA PRAME ZNF830 KLHDC4 MTHFSD UNKL SBNO2 NINJ2 XRCC1 ZNF202 SLBP KIRREL2 CIC FARSB TUBA1C DHRS13 ZKSCAN2 TMEM147 RNF224 NPTXR RPL12 GATAD2A SPRED2 LAPTM4B KRT8 TMEM248 SPRYD4 BRSK1 DDX49 TNK2 RPIA SAP30BP OGDH ZBTB17 STK16 THBS3 TEPP OBSL1 KLHL26 C1orf74 PDHA1 HHLA3 ANKRD54 NDUFV3 YTHDF2 ZNF276 NAPA ARF6 RTF1 CREB3 ENTPD8 POMZP3 RBM42 DCTN2 XPNPEP3 FAF1 KLHDC2 RPS3 PET100 MRPL2 SNRPC SLC25A5 DUS2 SGSM3 PDCL3 CDCA5 COQ9 VPS37B DMTN PIGU FBL ATG4B RFX1 SLC27A1 CYP51A1 WDTC1 APTX ZNF584 ACO2 LRSAM1 NUP85 MIR1205 AMIGO2 TRIP4 CDK11A TRPM4 HEMK1 CDYL ENTPD5 GORAB KCNK1 ZSCAN21 COPE RPL24 HPS6 PARP2 RNH1 SSBP1 EHMT1 WASH3P ZNF668 WDR25 CUEDC2 RPLP2 MUL1 TTC1 DGUOK NCAPG2 SNRNP40 KCNH2 RPRD1B SURF2 TMEM183A SCFD2 GIT1 LMNA FRMD8 ANKRD11 AHCYL2 INHA ARMC5 CCDC150 KANSL3 RPL41 CALR VPS37C STAG3L3 SPATA5L1 ZNF335 WNK1 LINC00471 LCMT1 MBIP RPL18 MFAP1 RPL31 ZNF609 RHOBTB3 BRD7 WDR74 UBAP2 SCYL3 CCDC107 MZF1 TIPIN STK11IP TPM3 SRD5A1 BUD31 SLC25A16 SLC29A4 CIAPIN1 TNNT1 DHX33 SAE1 AIMP1 PITPNA-AS1 SLC16A5 SLC35A4 FN3K RPS28 NFIC TFAP2A SH3YL1 FAU SMARCD2 PHF5A PAK1 EIF3A ZNF77 HUS1 AURKA APMAP DNAJB12 FKBP8 GAK RNF145 H6PD MDN1 CRKL BYSL BAIAP3 CCNB1 CYP4A22-AS1 SPSB3 ZNF554 LINC00470 ZFP36L1 MIF4GD TMCO3 SEC13 RNFT2 ZNF653 CD63 TFIP11 C8orf33 APBB3 ZNF133 NIPAL3 BOD1 SIVA1 MTMR4 PRKD2 PTMA TWISTNB SP8 HNRNPA2B1 ATL2 SLC26A8 MRPS27 LHPP KLHL7 RMDN3 FASN MMACHC IQCC TMEM127 TIGD6 POLR2J4 CHRNA5 STT3A SF3B5 DNAJB11 WDHD1 HDAC7 TIMM17A KLHL36 PGBD4 SF3A1 RIN1 ITPKC MTG1 MVK MAP2K1 ISOC1 PEF1 ACTR3C ZNF131 ZNF165 MSRB2 PRDX6 RHEB CTDP1 SERF2 NDUFAF3 IRGQ CCNK PRPSAP2 SPHK2 NUP214 HECTD1 MED19 ARMC10 NRBP1 USP20 EXO1 SENP2 CREB3L1 UCHL5 THEM4 TBC1D22A RRP15 UBC FAM122C SMARCD3 DANCR C6orf62 NFX1 DHX57 LINC00431 SDK1 ZNF446 HSF2BP BRCA1 ATP6V0A1 CCDC88B ABHD17A DHFR RNF7 RPN1 PIEZO1 RAB4B UBE4A OLFM2 CENPF RNU1-106P PIGA BAP1 TRMT5 SYT17 SUCLG1 TRIM24 NUP133 SNF8 KAT5 PDXK PAFAH2 LMNB1 RPS7 SLC35E3 GOLGA1 CENPL RNASEH2C ZNF710 CSTF1 CTDNEP1 ITM2C ZNF121 LINC00115 CCT4 CTCF RPL35A WDR81 CCAR2 RNU2-61P ATG4A KLK10 RALGDS RPL9 FBXO45 ZNF79 CAST KLHDC9 GMPPB CACYBP SLC35F5 STX16 RAE1 DALRD3 FARS2 G0S2 PIP5K1C RPL23A ELOVL6 NEDD4L MED20 LCLAT1 SLC33A1 ZDHHC7 PDCD7 LETMD1 VWDE TRMT61B IGF2BP1 CPSF1 GLOD4 KRT8P12 THAP7-AS1 UBA52 TIPARP NDUFA10 CIRBP RCN3 WDR43 CIB2 RPL23 DUSP10 up
## CREB3L4_TARGET_GENES 0.0011186 0.0084544 0.4874800 2.641405 0 1195 SSU72 FLAD1 CLPTM1L EIF3B DNTTIP1 ISG15 ATAD3A ATAD3B ZNF282 PRR7 SMARCA4 ZBTB45 UBE2I REPIN1 WDR55 DHDDS PGP SLC50A1 PMVK PEX16 WFDC3 POLD2 CA11 PIGO LRRC45 RPPH1 TNRC18 ALG3 DPH2 ZNF646 DDX23 EPCAM MRPS15 P4HB RNF207 NUDC LMTK2 GUSB LRRC14 TMEM222 PCGF1 TM9SF4 USP21 SLC12A9 CCDC86 GCDH FKBP2 CCT6A PAK6 DGCR8 RNF44 ECE2 DDX41 AARS2 ATXN2L CIB1 SYVN1 TIMM44 TSEN54 EVI5L PRCC DBNL NOP14 EXOSC5 EIF6 ENO1 PPAN SQSTM1 BECN1 FOXP4 ATG16L1 CCNJL FAM71E1 GOLGA3 SLC52A3 COMMD4 NELFA CDK2AP2 PDXP DOHH ACTR3B PICK1 HAX1 VPS9D1 COG4 DGAT2 LAS1L PIGG PSPH PELP1 PTGES2 TXLNA GALNT10 PRMT7 SRRT UBE2C ESRP2 EMC10 BET1L PSMD3 RRBP1 PPP1R37 CLDN7 GUK1 LINC00910 FDPS SNHG15 C2CD3 TBX6 SLC35B1 PAXIP1 NCL L2HGDH SF3A2 TCF3 DCXR DIS3L2 C1orf109 DHPS PPME1 ZNF785 TRAF4 PSMC4 MAN1B1 MET CDK4 DDX54 PTBP1 PHPT1 KCTD21 CCDC130 SNX8 XPO5 SETDB1 CPSF4 NPM3 HOXC-AS2 MAGEF1 WDR62 PRPF19 KLC2 CDCA7L PLEKHJ1 PUS1 GTF2F1 AATF GRHL3 CHMP1A UTP3 ACKR2 ADK FLYWCH2 NUTF2 HMGXB3 DNAJC16 NDUFS2 DNMT1 NET1 PKM VPS18 MRPL9 LGR4 MUC1 CISD3 COX19 ALDH18A1 BAZ2A TMEM259 NGDN GAS5 ARID1A TRA2A CD55 RPUSD4 PPIL2 ITPKA RBM47 PPIA RNASEH1 SF3B3 ZFP64 PPP6R1 PTOV1 THRAP3 CCT7 ZDHHC8P1 TSR1 DIAPH1 PSMA5 SNHG9 GCNT3 MRPL52 SRD5A3-AS1 RPS2 HS1BP3 ZNF384 AAAS LLGL2 RPS21 CDK12 WDR73 PDXDC1 EFTUD2 NXT1 BLZF1 ERV3-1 GPATCH2 USP54 LTBP3 PARN CHD2 ELMOD3 ZNF628 METTL3 ZC3H4 SRRM5 ANKRD18A CREBZF PRLR ZSWIM4 ALG8 AREG KIAA0895 ULBP3 ILF2 DPM2 COA6 MAZ ZDHHC5 TICAM1 TRIM52 RNY1 SGSM2 MYBPC1 ZNF425 MRPL51 DNAJC2 SRA1 ZWINT HSPD1 WWP2 NDUFS3 GOLGA5 ZC3H18 LINC01003 PSME3 MSANTD4 MVD CAPN8 KAZALD1 MLEC TP53BP1 TPGS1 EDC3 OAZ3 IRF2BP1 MRPS23 ALAD ZNF688 LSG1 STOML2 NAALADL2 ESRP1 SLC7A6OS CASP2 AMACR SPRED2 KRT8 RPL36AL PSMB10 METTL16 LIPE MAL2 RCCD1 FAM201A TM7SF3 USP35 SLC5A6 C1orf74 AGA PWWP2A CDCA7 R3HDM2 AKAP8L XPOT ZNF117 COX6B1 ZNF276 UQCRQ NUP93 SNRNP70 RUFY1 CCDC134 RIC8A GRHPR KLHDC2 RPS3 MTHFR CSAD BLVRB C12orf10 RRM2 TBC1D14 SETD1B GATAD2B TCERG1 NUP85 HDDC3 SNHG8 SZRD1 HIRA GEMIN2 NLN TNPO3 USE1 CASP9 RPL24 CASP6 SDHAF1 DRG2 RPL27 NOX1 IL6R PARP2 RPL10A ZNF668 ODF3B CUEDC2 OAT SCLY TTC1 CLNS1A MFSD5 PSMC2 UBIAD1 PRR15L CLTB GPRC5A ZNF689 PTCD1 ECSIT SRP54 ST7-AS1 PTRHD1 POLR2D TMEM209 PSMF1 MAN2C1 ASPH RPS20 RAB3A WNK1 WDR74 SP2 MGAT2 TIPIN RSBN1L SAE1 GOT2 TIMM10 TM9SF1 KIAA1217 PRPF8 ZC3H7A GBF1 TNFSF9 SH3YL1 TMEM65 RPL3 COX7C FGD6 ZNF77 CNPY2 MED15 FAM120AOS YEATS4 AURKA AHSA1 TRIO KIF2C SFI1 OSBP RNF145 FOXA2 MBD1 ZNF394 CTNS CRKL BYSL BCL2L15 OXA1L PINX1 ZFP36L1 MIF4GD FAM200A RNFT2 EIF4EBP1 POLH HADH RPP38 KDM4B COX14 AURKB PTMA NEK2 MED26 ATL2 BRIX1 C12orf65 PFDN4 FAM118B TIGD6 PSMG4 XXYLT1 CRELD1 MAP3K6 GLO1 ERI2 MVK CLIP1 PPA1 CHAC1 ISOC1 PEF1 CNPY3 ZNF860 ZNF131 FERMT1 IRGQ NEAT1 PPIB CTNNA1 ZNF317 TMCC1 GINS4 NUB1 THEM4 TBC1D22A CENPN HOXA1 CNGA1 CA13 TTF2 EZH2 RPS24 NFX1 MBTPS1 COL17A1 ZNHIT6 AIP DHFR SCAPER RAB4B MTMR12 LRPPRC C12orf49 SCAMP5 SNX12 VPS28 BAP1 KCTD7 EIF3H KDM4A PUM1 PCNA PDSS2 KAT5 SMARCAL1 CEP164 SMG1 CEP350 PAFAH2 CFDP1 KIF3A PSMD8 FBXO28 LMNB1 NIPA1 OSBPL3 SLC35E3 RABEPK VPS33B CSTF1 CTDNEP1 ARHGAP32 CCT4 AFG3L2 MRFAP1 TCTA SLC5A2 TRIB1 TMEM115 GOT1 RHOF SLC35A3 TYMS ZNF79 HTATIP2 MCM5 CACYBP TADA3 SAR1B PHYKPL MED20 CLCN6 RNY4 RNU6-2 COPZ1 UBN2 CSNK2A1 GTF3C4 FBXO16 ENPP3 CIRBP ANP32B CITED2 HOMER1 TMEM106C DUSP10 RDH10 FOSL1 KNSTRN CPT2 SFXN5 TSN SDHC CYB5A TUBGCP5 PARP16 ARHGEF2 ST7 GZF1 UNC93B1 TPI1P2 THBS4 CETN3 up
## ATOH1_TARGET_GENES 0.0013986 0.0084544 0.5601978 2.634839 0 194 TBL3 TELO2 MST1P2 MRPL24 C16orf91 FBXL19 SHARPIN KCTD5 MRPS15 ABCF2 GUSB HDGF CIAO1 NTHL1 PRCC NOP14 AUP1 SETD1A NELFA FEM1A CLPB TSC2 CROCCP2 SCNM1 SLC27A5 SCAF1 SART1 PPP1R37 ZNF444 TRAPPC3 C1orf109 FAF2 HNRNPAB PANK4 PSMC3 EIF2B4 PHF12 PPRC1 C19orf53 RPL36 CHD2 CHCHD3 COPS7B FBXW9 DFFA CHMP4B ORMDL3 HSD11B1L NDUFS3 MED18 GBA PTDSS2 ZNF354A CYB561D2 SYMPK MGME1 ARF6 PPP1R12C LYSMD1 BRPF1 NPRL2 COMMD7 STAU1 SF3A3 AHCYL2 MAF1 WNK1 SNRNP35 TIPIN GSK3A TIMM9 RNU5B-1 STX6 COX7C BRF1 ZNF749 BOD1 C17orf75 DNMT3B MMACHC TMEM127 SNRPD3 MAP2K1 ZNF131 DCLRE1A CTDP1 CTNNA1 GUCD1 BUB1B POM121C SFSWAP C15orf48 CEP350 GGNBP2 RPS7 CCT4 CCAR2 TMEM115 SAR1B CCDC117 GLOD4 SNX5 HARBI1 ZNF354B KAT2A up
## DLX6_TARGET_GENES 0.0012330 0.0084544 0.5138125 2.634581 0 486 ZNF692 DNAJA3 ABCB9 COASY EIF3B FBXL19 OPLAH ZNF786 SH2D3A TMCO4 PPP1R14B USF1 ZNHIT1 TRIB3 MRPS15 MPG HDGF TM9SF4 PHLDA2 ZNF398 GTPBP2 EARS2 STX10 ATXN2L ZNF48 PRCC EIF6 SNHG11 ENO1 TFF2 SRRM2 GOLPH3 PDAP1 BECN1 TMEM54 SETD1A GOLGA3 FEM1A SEC24C FEN1 HKDC1 HAX1 COG4 RHBDF1 SRRT SCAF1 ESRP2 CCDC124 BRD9 STK40 STAT6 CLDN7 NCDN LINC00910 TBX6 MRPS33 NSUN2 TRMT12 NOP56 CBX3 MVB12A YIPF3 FPGS PSAT1 AP5Z1 CDK4 SNX8 HOXC-AS2 FAF2 PLOD3 MRPL27 SNRPA DAGLB SHMT2 CISD3 TTI1 MCCC2 RBM47 SF3B3 KPTN THRAP3 UBFD1 FTSJ3 PSMB5 PSMA5 ACAD9 ASF1B STK35 RBBP5 TIMM13 MPDU1 USP54 SNORA84 HIRIP3 FAM13A PRLR GSPT1 PAAF1 ALG8 EFNA1 BST2 ZDHHC5 SNORD46 LBX2 GART PSME3 CLDN12 KAZALD1 EDC3 MALAT1 FARSB LTBR RAD50 PSMC5 KRT8 CNPPD1 ARPC5L XPOT LRRC41 LAMB3 SEPHS2 UQCRQ RTF1 KIAA0319L ZNF574 PDP2 CS BCL3 ZMYND8 SNHG8 TNPO3 GMPR2 PPP1R13L RNH1 INO80E SHC1 STX4 WDR25 RPL27A HOXA11 ACY3 RPL19 GPRC5A SRP54 MED24 RPL41 SPATA5L1 RPL22 TMEM258 CBR1 WDR74 KCTD21-AS1 RPL30 SLC3A2 SRD5A1 BUD31 IL23A NOD1 MRPS11 SAE1 NAPEPLD ADCY9 SLC16A5 RAB27A SLC35A4 TM9SF1 TFAP2A DSN1 PAN2 SFXN4 UQCRH PPP1R1B AHSA1 KIF2C OSBP RPS12 CCNB1 OXA1L CAND1 APBB3 ZNF133 HINT1 RPS14 PTMA KPNB1 HNRNPA2B1 CDC42SE1 ATP6V1E2 AKAP9 ZNF131 NUDT5 NEMF CTDP1 SERF2 RPL32 MIR4258 PDIK1L CD3EAP DANCR EME1 MRPL54 YARS2 BRCA1 DHFR RPN1 LRPPRC NDUFA4 HDAC1 EHF SFSWAP SRRM2-AS1 FTH1 UQCRC2 up
fgsea_plot(fgsea_res$res_c4, pathways_title='C4 cancer', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## MORF_CSNK2B 0.0013850 0.0053283 0.6442145 3.091832 0 258 SLC4A2 TBL3 EIF3B UBAP2L RER1 PDCD6 DAP3 AP3D1 GGCT ATIC EIF3C NDUFS8 CTBP1 RNPEP LARP1 TUFM DHCR7 HDGF NDUFV1 PPM1G JTB CYC1 PDAP1 CCT3 LSM4 COMMD4 SEC24C FEN1 SNRNP200 EIF4G1 HAX1 GPX4 TRAPPC3 NHP2 SF3A2 LMNB2 RAD23A CBX3 CCT5 CDK4 MAEA TMED9 FIBP HNRNPAB IMPDH1 RUVBL2 PRMT1 CLTA SNRPA KXD1 NDUFS2 CHERP EIF3I DAP MRPL9 SF3B2 NDUFAB1 MAP2K2 CHD4 SNRPE EIF2B4 ILF3 GNB2 PTOV1 CCT7 NONO NDUFS5 TRIM28 SDHA PRRC2C TECR PARK7 MCM7 RALY PSMB4 ALG8 CCT2 DDX19B SMG7 HSPA9 DOCK3 C1QBP HSPD1 NDUFS3 DDOST RAD23B MPV17 BANF1 PPP1CA TUBB2A TMEM147 PSMB2 DDX49 HNRNPUL1 COA1 COX6B1 DCTN2 CS COX4I1 FBL SLC1A5 FUS COPE AKR7A2 SNRPD2 SSBP1 DGUOK FAM120A COX6C MFAP1 SLC3A2 SDHB NDUFC1 SMARCD2 KDELR1 UQCRH EI24 GPI SEC13 CLPP SRSF1 HUWE1 ERP29 ACLY HNRNPA2B1 COX5B UBE2L3 POLR2I GLO1 SF3A1 GANAB RAC1 PUF60 XRCC6 ESPL1 RHEB ARHGDIA TARDBP PPP2R1A URM1 MBTPS1 UQCRC1 HDAC1 SRSF9 PCNA PSMD8 ACOT7 UQCRC2 CTDNEP1 AFG3L2 RBM14 RBMX ANP32B DRG1 PPP1R7 COX5A SNRPG EIF4E2 VDAC1 PSMD9 up
## MORF_AATF 0.0014514 0.0053283 0.6480427 3.012725 0 191 AIMP2 UBE2I DAP3 MTX1 BMS1 ALG3 TFAP4 WDR18 NUDC TUFM EIF2B5 RNPS1 EIF6 CYC1 DNAJC11 MTOR PKMYT1 SNRNP200 MFN2 THOP1 TXLNA SRRT PSMD3 TRAPPC3 LSM7 NCL RUVBL1 RAD23A GNL2 PRKCSH FIBP AATF HNRNPAB SSRP1 NELFB RUVBL2 SNRPA KXD1 EIF3I MRPL9 SGTA TRRAP COPS6 KDM3B NONO PSMD2 SDHA XPO6 CAD RALY PRKDC IDH3B BRD8 MCM2 SMARCC2 CCT2 ILF2 MLEC TP53BP1 HNRNPU CNPPD1 DDX49 PSMB6 PHB SRRM1 DHX38 CS PSMB3 COQ9 PIN1 POLR2A FUS PABPN1 NUP62 SSBP1 CLNS1A MMS19 ARFGAP2 PRPF8 DDX39A SDR39U1 AHSA1 NUP188 GTF2A2 OXA1L RTCB PABPC4 TCOF1 HADH HUWE1 ACLY HNRNPA2B1 UBE2L3 TIMM17A POLR2I PUF60 CSK ALDH4A1 RPN1 DDB1 LRPPRC SFSWAP HSPA8 SAFB IMMT CTDNEP1 CCT4 AFG3L2 CLSTN1 MCM5 DRG1 NAE1 POLR2C KAT2A IK DDX18 CANX SERP1 ATXN10 TCEA1 PRKAG1 ADSL NAP1L4 KHDRBS1 EIF3K TERF2IP up
## MORF_PHB 0.0015456 0.0053283 0.6910981 3.005159 0 113 OTUB1 MTX1 IGSF9B BMS1 SH2B1 TFAP4 WDR18 ADAM15 PCGF1 CIB1 TSTA3 EIF6 PKMYT1 B4GALT3 MFN2 MRPL28 FDXR PSD4 ERAL1 SRRT RABGGTA PSMD3 ILVBL GNL2 PRKCSH BAHD1 HMG20B CPSF4 WDR62 AATF NELFB CSNK1D BPHL COPS6 PSMD2 XPO6 CAD PARN TPR ILF2 PCGF2 SPRN MCRS1 MLEC TP53BP1 RPRD2 CNPPD1 PSMB6 GRK6 MPST DDX11 PHB TOMM34 CS POLR2A FANCG PABPN1 NUP62 BRD3 DRG2 NFRKB LSM12 CHD3 PRPF8 SDR39U1 NUP188 TUBGCP2 SLC25A11 RTCB PLIN3 TCOF1 MEA1 TIMM17A ELK1 ALDH4A1 DDB1 SFSWAP CCT4 AFG3L2 up
## MORF_SOD1 0.0013986 0.0053283 0.6279866 3.001640 0 247 SLC4A2 TBL3 EIF3B UBAP2L AIMP2 PDCD6 GGCT ATIC EIF3C NDUFS8 NUDC LARP1 TUFM NDUFV1 PPM1G CYC1 CCT3 LSM4 FEN1 SNRNP200 HAX1 ENSA FDPS TRAPPC3 NHP2 RAD23A CBX3 CCT5 CDK4 FIBP HNRNPAB RUVBL2 PRMT1 SNRPA KXD1 NDUFS2 CHERP EIF3I DAP MRPL9 SF3B2 NDUFAB1 MAP2K2 SNRPE EIF2B4 ILF3 SEC61G PRDX4 CCT7 NONO NDUFS5 TRIM28 SDHA TECR PARK7 PSMB4 GSPT1 ALG8 CCT2 ILF2 SMG7 HSPA9 DOCK3 C1QBP HSPD1 NDUFS3 RAD23B MPV17 BANF1 PPP1CA HNRNPU STOML2 TMEM147 PSMB2 DDX49 PSMB6 COA1 XPOT NME1 DCTN2 CS COX4I1 FBL MRPL3 FUS AKR7A2 PGRMC1 SSBP1 ETFA DGUOK CLNS1A MAML1 FAM120A COX6C MFAP1 SLC3A2 NDUFC1 SMARCD2 UQCRH EI24 AHSA1 CCNB1 SEC13 UTP18 SRSF1 HUWE1 ACLY HNRNPA2B1 HSPA4 MORF4L2 UBE2L3 TBCA POLR2I GLO1 GANAB RAC1 PUF60 RHEB TARDBP PPP2R1A C6orf62 LRPPRC SRSF9 HSPA8 PCNA CFDP1 PSMD8 ACOT7 UQCRC2 CTDNEP1 AFG3L2 RBMX ANP32B DRG1 TMEM106C PPP1R7 COX5A PSMA3 RPA1 SNRPG EIF4E2 MAGOH ATOX1 VDAC1 PSMD9 up
## MORF_BUB3 0.0014184 0.0053283 0.6284570 2.987520 0 243 UBAP2L EDC4 DAP3 AK2 RNPEP NUDC TUFM NDUFV1 SRM PPM1G CYC1 CCT3 LSM4 DNAJC11 SEC24C FEN1 SNRNP200 THOP1 HAX1 RANGAP1 TRAPPC3 LSM7 NCL SF3A2 LMNB2 RAD23A CBX3 CHAF1A CCT5 TMED9 FIBP AATF HNRNPAB SSRP1 TXNL4A IMPDH1 RUVBL2 SNRPA KXD1 NDUFS2 DNMT1 CHERP KHSRP EIF3I MRPL9 SF3B2 MAP2K2 SNRPE ILF3 CCT7 NONO NUDT1 NDUFS5 TRIM28 SDHA PARK7 MCM7 CAD RSL1D1 PRKDC BRD8 MCM2 TFDP1 CCT2 DDX19B ILF2 HSPA9 DOCK3 ZWINT NDUFS3 PAICS DDOST UBE2S HNRNPU SLBP PSMB2 DDX49 HNRNPUL1 XPOT SRRM1 CS FBL SLC1A5 FUS PDIA6 IMPDH2 TNPO3 AKR7A2 SSBP1 DGUOK GOT2 PRPF8 SDHB NDUFC1 ANP32A UQCRH EI24 AHSA1 NUP188 GTF2A2 MCM3 PABPC4 CLPP HADH SRSF1 ERP29 AURKB ACLY HNRNPA2B1 MRPS27 BUB1 UBE2L3 POLR2I HNRNPM GLO1 GANAB PPIE CSK XRCC6 ESPL1 RHEB FH TARDBP PPP2R1A UQCRC1 LRPPRC HDAC1 POLA2 SRSF9 SAFB PCNA IMMT PSMD8 CTDNEP1 AFG3L2 TYMS MCM5 RBMX ANP32B DRG1 NAE1 VDAC1 SOD1 NASP DUT SREBF2 SERP1 ATXN10 TCEA1 RFC4 GMPS KHDRBS1 MTDH up
## MORF_DDB1 0.0014045 0.0053283 0.6312123 2.981885 0 226 SLC4A2 DAP3 OTUB1 MTX1 BMS1 ALG3 SH2B1 TFAP4 WDR18 ADAM15 PCGF1 PDIA4 EIF2B5 ATXN2L CIB1 TSTA3 EIF6 PDAP1 BECN1 FOXK2 GOLGA3 PKMYT1 B4GALT3 SNRNP200 MFN2 MRPL28 FDXR RERE TXLNA SRRT RABGGTA PSMD3 ILVBL GNL2 PRKCSH UBE3C BAHD1 CPSF4 WDR62 AATF HNRNPAB SSRP1 NELFB RUVBL2 KXD1 ERCC2 TTI1 NCOR2 SGTA PRDX4 TRRAP CSNK1D BPHL COPS6 KDM3B NONO PSMD2 SDHA XPO6 PDXDC1 CAD PEX6 PRKDC PARN SNAPC5 IDH3B DNPH1 BRD8 MCM2 SMARCC2 TPR ILF2 PCGF2 SPRN DOCK3 DRAP1 ATG9A MLEC TP53BP1 CSNK1G2 RPRD2 TMED1 PSMB6 YIF1A MPST DDX11 DDX46 PHB TOMM34 CS PIN1 POLR2A FANCG NUP62 BRD3 PARP2 MMS19 NFRKB CHD3 PRPF8 DDX39A SDR39U1 AHCYL1 NUP188 TUBGCP2 SLC25A11 RTCB PLIN3 TCOF1 MEA1 HUWE1 HNRNPA2B1 PRPF4 KPNA6 RAC1 PUF60 ELK1 ALDH4A1 DDB1 LRPPRC SFSWAP ABR HSPA8 CTDNEP1 CCT4 AFG3L2 RANBP3 COX8A CLSTN1 OARD1 CSNK2A1 DRG1 POLR2C KAT2A ACTN4 CETN3 HNRNPL EML3 DDX18 CANX SERP1 HLTF TCEA1 SEC23IP PRKAG1 NAP1L4 KHDRBS1 PARG up
## MORF_FBL 0.0015408 0.0053283 0.6767698 2.979015 0 129 TBL3 EIF3B UBE2I EIF3C TUFM HDGF NDUFV1 RNPS1 PPM1G JTB CYC1 PDAP1 CCT3 LSM4 AHCY LSM7 NCL SF3A2 RAD23A CBX3 FIBP HNRNPAB RUVBL2 PRMT1 SNRPA KXD1 EIF3I MRPL9 EIF3G SNRPE ILF3 CCT7 NONO NUDT1 TRIM28 PARK7 MCM7 RSL1D1 RALY IDH3B MCM2 CCT2 ILF2 DOCK3 C1QBP HSPD1 NDUFS3 HSP90AB1 DDOST HNRNPA1 BANF1 TMEM147 PSMB2 DDX49 HNRNPUL1 COA1 NME1 CS SNRPB FBL FUS IMPDH2 SNRPD2 RPL10A SSBP1 CLNS1A FAU UQCRH GPI RPL14 AURKB TOMM20 HNRNPA2B1 UBE2L3 POLR2I PUF60 XRCC6 BTF3 TARDBP PPP2R1A SUMO3 SRSF9 PCNA PSMD8 up
## MORF_RAN 0.0014205 0.0053283 0.6242359 2.963424 0 239 EEF1D PDCD6 UBE2I DAP3 EIF3C CTBP1 TUFM HDGF NDUFV1 RNPS1 PPM1G JTB CYC1 PDAP1 CCT3 COMMD4 SNRNP200 HAX1 POLR2H FDPS NCL RAD23A CBX3 MYL6B PTBP1 FIBP HNRNPAB RUVBL2 PRMT1 GNAS CLTA SNRPA KXD1 MRPL9 NDUFAB1 SNRPE PPIA CCT7 COPS6 NONO NIPSNAP1 NDUFS5 TRIM28 SDHA PARK7 RALY IDH3B PSMB4 CCT2 ILF2 MRPL23 RPL11 DOCK3 C1QBP HSPD1 NDUFA1 NDUFS3 HSP90AB1 BANF1 RPL13 PPP1CA TUBB2A STOML2 TMEM147 PSMB2 MRPS12 RPL36AL DDX49 HNRNPUL1 PSMB6 COA1 COX6B1 NME1 DCTN2 CS SNRPB SLC25A5 PSMB3 COX4I1 SSR2 FBL FUS RPS5 COPE RPL24 SNRPD2 SSBP1 PABPC1 RPLP2 CLNS1A RPN2 RPL18 COX6C RPL30 FAU SMARCD2 COX7C UQCRH EEF2 RPS12 GPI UTP18 HUWE1 ERP29 HINT1 RPL14 ACLY HNRNPA2B1 COX5B UBE2L3 POLR2I GANAB RAC1 PUF60 RPS10 XRCC6 RHEB BTF3 TARDBP PPP2R1A RPS24 SUMO3 HDAC1 SRSF9 EIF3H HSPA8 PCNA PSMD8 UQCRC2 NDUFA2 CTDNEP1 COX8A RPS6 RPL23A RBMX ANP32B DRG1 PPP1R7 COX5A SNRPG NACA RPS27A PSMC1 SOD1 CANX ATXN10 TCEA1 up
## MORF_RAD23A 0.0013605 0.0053283 0.6055727 2.951098 0 304 TBL3 EIF3B UBAP2L EDC4 FARSA AP3D1 AK2 NDUFS8 CTBP1 RNPEP NUDC LARP1 TUFM DHCR7 HDGF CIAO1 NDUFV1 RNPS1 PPM1G JTB CYC1 LSM4 DNAJC11 SEC24C MGRN1 SNRNP200 THOP1 HAX1 DEAF1 TRAPPC3 NCL SF3A2 LMNB2 RAD23A CBX3 CCT5 RNF126 TMED9 NPM3 FIBP AATF HNRNPAB TXNL4A IMPDH1 RUVBL2 NUP205 CLTA SNRPA KXD1 NDUFS2 DNMT1 CHERP KHSRP EIF3I MRPL9 SF3B2 MAP2K2 CHD4 SNRPE DDX19A ILF3 GNB2 CCT7 NONO NUDT1 DIAPH1 NDUFS5 TRIM28 SDHA PRRC2C PARK7 CAD RSL1D1 PRKDC CHMP2A IDH3B MCM2 TFDP1 CCT2 DDX19B ILF2 HSPA9 DOCK3 ZWINT NDUFS3 DDOST HNRNPU SLBP PSMB2 MRPS12 DDX49 RPIA HNRNPUL1 XPOT SRRM1 DHX38 CS POLR2A FBL SLC1A5 FUS PDIA6 TNPO3 PABPN1 COPE AKR7A2 SSBP1 TTC1 DGUOK FAM120A MFAP1 SLC3A2 GOT2 PRPF8 SDHB DDX39A NDUFC1 SMARCD2 ANP32A UQCRH EI24 AHSA1 NUP188 SMARCC1 GTF2A2 MCM3 RTCB PABPC4 CLPP HADH SRSF1 ERP29 TOMM20 ACLY HNRNPA2B1 UBE2L3 POLR2I HNRNPM GLO1 SF3A1 GANAB PPIE PUF60 ZNF131 CSK XRCC6 ESPL1 RHEB FH PKN1 TARDBP PPP2R1A UQCRC1 RPN1 PIEZO1 LRPPRC HDAC1 POLA2 SRSF9 EIF3H SAFB IMMT ACOT7 CTDNEP1 AFG3L2 TYMS RBMX DGKZ KRIT1 ANP32B DRG1 PPIF MAGOH VDAC1 SOD1 DUT SREBF2 CANX SERP1 ATXN10 TCEA1 RFC4 GMPS KHDRBS1 MTDH up
## MORF_DAP3 0.0014706 0.0053283 0.6379739 2.944815 0 179 TBL3 UBE2I DAP3 ALG3 CTBP1 TUFM NDUFV1 EIF2B5 JTB EIF6 CYC1 PDAP1 CCT3 SNRNP200 HAX1 POLR2H FDPS TRAPPC3 NCL CBX3 FIBP AATF HNRNPAB IMPDH1 NELFB RUVBL2 SNRPA KXD1 EIF3I MRPL9 SNRPE EIF2B4 CCT7 COPS6 NONO NIPSNAP1 PSMD2 SDHA PARK7 RALY IDH3B PSMB4 BRD8 SMARCC2 CCT2 ILF2 MRPL23 HSPD1 NDUFS3 HSP90AB1 DDOST DNPEP BANF1 STOML2 TMEM147 PSMB2 DDX49 HNRNPUL1 PSMB6 COX6B1 CS SNRPB SLC25A5 PSMB3 COX4I1 SSR2 PIN1 BRD3 DGUOK CLNS1A RPN2 ARFGAP2 FAM120A COX7C SDR39U1 UQCRH AHCYL1 TBCB NUP188 OXA1L RTCB HUWE1 ACLY HNRNPA2B1 COX5B UBE2L3 POLR2I GANAB PUF60 RHEB DDT PPP2R1A DDB1 LRPPRC SRSF9 HSPA8 PSMD8 ZNF146 CTDNEP1 AFG3L2 COX8A up
## MORF_PPP1CA 0.0015152 0.0053283 0.6499180 2.929869 0 153 UBAP2L RER1 EEF1D PDCD6 GGCT ATIC EIF3C CTBP1 TUFM HDGF NDUFV1 PPM1G JTB CYC1 PDAP1 ENSA HARS2 CBX3 FIBP HNRNPAB PRMT1 CLTA DAP MRPL9 SF3B2 SNRPE PSMC3 CCT7 NONO C9orf16 TRIM28 TECR PARK7 ARPC1B RALY PSMB4 CCT2 SMG7 HSPD1 PSMC6 NDUFA1 NDUFS3 RAD23B DNPEP BANF1 PPP1CA STOML2 TMEM147 PSMB2 RPL36AL DDX49 HNRNPUL1 COX6B1 DCTN2 COX4I1 SSR2 COPE SNRPD2 ETFA FAM120A COX6C BUD31 SMARCD2 CDIPT ARF5 AP1B1 UTP18 ERP29 COX5B TBCA POLR2I GANAB PUF60 ARHGDIA PPP2R1A URM1 MBTPS1 SUMO3 VCP UBE4A HDAC1 SRSF9 CFDP1 PSMD8 NDUFA2 CTCF CLEC18C RBMX ANP32B DRG1 PPP1R7 COX5A PSMA3 SNRPG EIF4E2 PSMD9 PSMC1 SOD1 CANX COIL KHDRBS1 MTDH EIF3K up
## MORF_EIF3S2 0.0014286 0.0053283 0.6224087 2.925578 0 220 SLC4A2 TBL3 UBE2I DAP3 AK2 ALG3 RNPEP WDR18 NUDC TUFM CIAO1 NDUFV1 SRM RNPS1 PPM1G CYC1 LSM4 PKMYT1 SNRNP200 THOP1 DEAF1 TXLNA LSM7 NCL SF3A2 RAD23A CBX3 CHAF1A NPM3 FIBP AATF HNRNPAB SSRP1 TXNL4A IMPDH1 RUVBL2 SNRPA KXD1 NDUFS2 DNMT1 EIF3I MRPL9 MAP2K2 SNRPE ILF3 GNB2 CCT7 NONO NUDT1 NDUFS5 PSMD2 PARK7 CAD RSL1D1 PRKDC IDH3B BRD8 MCM2 CCT2 DDX19B ILF2 DOCK3 DDOST MLEC PSMB2 DDX49 RPIA SRRM1 CS SLC25A5 COQ9 PIN1 POLR2A FBL FUS PDIA6 IMPDH2 PABPN1 AKR7A2 EIF3D SSBP1 DGUOK CLNS1A SLC3A2 PRPF8 SDHB RAD54L UQCRH NUP188 GPI GTF2A2 OXA1L RTCB PABPC4 CLPP TCOF1 HADH HUWE1 RPL14 TOMM20 ACLY HNRNPA2B1 MRPS27 UBE2L3 TIMM17A POLR2I GANAB PPIE ZNF131 CSK XRCC6 RHEB FH PPIB PPP2R1A RPN1 LRPPRC SRSF9 EIF3H SAFB IMMT CTDNEP1 CCT4 AFG3L2 DRG1 NAE1 POLR2C VDAC1 SOD1 ATF4 DUT SREBF2 SERP1 ATXN10 TCEA1 LDHB PRKAG1 RFC4 NAP1L4 KHDRBS1 up
## MORF_NME2 0.0015198 0.0053283 0.6557438 2.921663 0 141 EEF1D UBE2I OTUB1 TSR3 LYPLA2 HDGF JTB CYC1 ENO1 PDAP1 POLR2H EEF1A2 GNAS ALDOA SNRPE PPIA CCT7 COPS6 SSNA1 C9orf16 RPL38 RALY PSMB4 MRPL23 RPL11 HSPD1 NDUFA1 HSP90AB1 RPL8 DNPEP BANF1 RPL13 STOML2 TMEM147 RPL12 RPL36AL RPL35 COX6B1 NME1 SNRPB RPS3 COX4I1 SSR2 SPAG7 RPS5 RPL24 RPS27 RPLP0 RPL27 PABPC1 RPLP2 RPL27A RPL19 RPS16 CALR RPS20 RPL18 RPL31 RPL18A RPL30 FAU RPS29 COX7C RPS11 EEF2 TBCB ARF5 RPS12 HUWE1 HINT1 RPS14 RPL13A COX5B GANAB PUF60 RPS10 RPL32 BTF3 UBC RPS24 URM1 CFL1 SUMO3 PSMD8 RPS7 NDUFA2 COX8A RPL9 RPS6 RPL23A RPS4X DRG1 NACA RPS15A RPS27A RPS8 PSMC1 up
## MORF_UBE2I 0.0014409 0.0053283 0.6141000 2.880429 0 219 UBN1 EEF1D UBE2I DAP3 OTUB1 CTBP1 LYPLA2 TUFM HDGF RNPS1 JTB EIF6 CYC1 PDAP1 SNRNP200 SART1 LSM7 HGS NCL CBX3 PTBP1 AATF HNRNPAB GNAS KXD1 EIF3I MRPL9 NGDN CHD4 SNRPE PPIA ILF3 GNB2 CCT7 COPS6 NONO NUDT1 TRIM28 PARK7 ZNF384 RALY IDH3B BRD8 CCT2 ILF2 MRPL23 RPL11 HSPD1 NDUFS3 HSP90AB1 HNRNPA1 BANF1 RPL13 CNPPD1 DDX49 TOP1 HNRNPUL1 COX6B1 SNRNP70 DHX38 CS SNRPB PSMB3 COX4I1 SSR2 POLR2A FBL FUS RPS5 RPL24 EIF3D RPL27 RPL10A PABPC1 RPLP2 RPL19 ARFGAP2 RPL22 RPL18 RPL31 RPL18A RPL30 PRPF8 FAU COX7C SDR39U1 UQCRH RPS11 EEF2 TBCB NUP188 RPS12 OXA1L HUWE1 HINT1 RPL14 PTMA HNRNPA2B1 COX5B UBE2L3 POLR2I HNRNPM GANAB PUF60 CSK XRCC6 BTF3 UBC TARDBP PPP2R1A RPS24 CFL1 SUMO3 SRSF9 EIF3H PUM1 PSMD8 RPS7 CTDNEP1 COX8A RPL9 RPS6 RBMX ANP32B DRG1 NACA RPS27A ZFPL1 IK ATF4 CANX ATXN10 up
## MORF_PRKDC 0.0014925 0.0053283 0.6259804 2.856579 0 166 AK2 BMS1 ALG3 RNPEP TFAP4 WDR18 NUDC PWP2 SRPK1 DNAJC11 PKMYT1 SNRNP200 THOP1 DEAF1 TXLNA PSMD3 RUVBL1 RAD23A CHAF1A GNL2 CCT5 NPM3 AATF SSRP1 TXNL4A RUVBL2 SNRPA KXD1 DNMT1 KHSRP EIF3I SHMT2 TRRAP NONO NUDT1 DIAPH1 PSMD2 XPO6 CAD PRKDC BRD8 MCM2 TFDP1 DDX19B ILF2 DFFA ZWINT MLEC HNRNPU SLBP RPIA DDX46 SRRM1 CS COQ9 PIN1 POLR2A CDK11A TNPO3 PABPN1 NUP62 AKR7A2 SSBP1 ARID3A MMS19 MZF1 GOT2 PRPF8 DDX39A RAD54L ANP32A EI24 NUP188 SMARCC1 GTF2A2 MCM3 PABPC4 TCOF1 HADH HNRNPA2B1 MRPS27 TIMM17A PPIE ZNF131 FH BUB1B RPN1 DDB1 LRPPRC SAFB IMMT CTDNEP1 CCT4 PDIA3 AFG3L2 TYMS MCM5 NAE1 HNRNPL DUT SREBF2 DDX18 ATXN10 TCEA1 RFC4 KHDRBS1 up
## MORF_XRCC5 0.0014265 0.0053283 0.6099695 2.851144 0 209 UBE2I DAP3 AP3D1 CTBP1 RNPEP WDR18 NUDC TUFM NDUFV1 RNPS1 RNF44 PPM1G JTB DNAJC11 MGRN1 SNRNP200 THOP1 HAX1 TXLNA TRAPPC3 LSM7 NCL RAD23A CHAF1A PTBP1 FIBP AATF HNRNPAB SSRP1 TXNL4A IMPDH1 RUVBL2 SNRPA KXD1 NDUFS2 DNMT1 EIF3I SNRPE DDX19A TRRAP CCT7 NONO NUDT1 DIAPH1 NDUFS5 PARK7 PRKDC IDH3B BRD8 MCM2 SMARCC2 CCT2 DDX19B ILF2 DOCK3 MLEC HNRNPU SLBP DDX49 RPIA HNRNPUL1 SNRNP70 SRRM1 CS COQ9 PIN1 POLR2A FUS PDIA6 TCERG1 PABPN1 AKR7A2 EIF3D SSBP1 PRPF8 SDHB ANP32A UQCRH AHSA1 NUP188 SMARCC1 GTF2A2 DHX9 PABPC4 CLPP HADH SRSF1 TOMM20 ACLY HNRNPA2B1 COX5B UBE2L3 TIMM17A HNRNPM GANAB PPIE CSK XRCC6 FH TARDBP RPN1 LRPPRC HDAC1 POLA2 SRSF9 EIF3H SAFB IMMT CTDNEP1 AFG3L2 up
## MORF_AP2M1 0.0014347 0.0053283 0.6123297 2.850882 0 203 SLC4A2 RER1 EEF1D UBE2I DAP3 AP3D1 OTUB1 EIF3C CTBP1 TSR3 LYPLA2 P4HB HDGF JTB CYC1 CAPN1 PDAP1 COMMD4 COG4 POLR2L POLR2H ENSA GPX4 TRAPPC3 CBX3 TMED9 HNRNPAB PLOD3 IMPDH1 PRMT1 GNAS CLTA KXD1 PKM MRPL9 SF3B2 MAP2K2 SNRPE PPIA GNB2 CCT7 COPS6 SSNA1 C9orf16 SDHA RALY IDH3B PSMB4 MRPL23 NDUFA1 HSP90AB1 DDOST DNPEP BANF1 PPP1CA TUBB2A STOML2 TMEM147 MRPS12 RPL36AL DDX49 MAP3K11 HNRNPUL1 PSMB6 COX6B1 SEPHS2 DCTN2 SNRPB COX4I1 SSR2 COPE STX4 RPN2 ARFGAP2 CALR TCF25 BUD31 FAU SMARCD2 KDELR1 COX7C TBCB ARF5 GPI AP1B1 HUWE1 COX5B MORF4L2 UBE2L3 POLR2I GANAB RAC1 PUF60 XRCC6 RHEB ARHGDIA UBC PPP2R1A URM1 LASP1 CFL1 WBP2 SUMO3 PIEZO1 VCP SRSF9 HSPA8 PSMD8 NDUFA2 CTDNEP1 COX8A CLEC18C TADA3 ANP32B DRG1 PPP1R7 EIF4E2 NACA ATOX1 ACTN4 PSMC1 up
## MORF_PSMC1 0.0014793 0.0053283 0.6175581 2.839939 0 175 EIF3B RER1 EEF1D PDCD6 ADAR GGCT ATIC EIF3C TSR3 JTB CYC1 ADRM1 VPS72 COMMD4 POLR2H ENSA HARS2 CBX3 EEF1A2 PSMC4 MAEA HNRNPAB PRMT1 PPP4C CLTA MRPL9 SF3B2 NDUFAB1 AKT1 SNRPE PSMC3 CCT7 SSNA1 PSMB5 C9orf16 TECR PSMB4 CCT2 SMG7 PSMC6 NDUFA1 NDUFS3 SLC7A5P1 RAD23B DNPEP BANF1 MAD2L1BP PPP1CA STOML2 TMEM147 PSMC5 RPL36AL HNRNPUL1 COX6B1 SEPHS2 RBM42 DCTN2 PAF1 COX4I1 SSR2 ETFA PITRM1 PSMC2 TMEM183A COX17 BUD31 MRPS11 TM9SF1 SMARCD2 CDIPT ARF5 SEC13 RPP38 UTP18 SIVA1 NDUFB1 MORF4L2 TBCA PUF60 ARHGDIA PPP2R1A URM1 MBTPS1 SUMO3 VCP UBE4A CFDP1 PSMD8 NDUFA2 CTCF CLEC18C STX16 RAE1 GLOD4 ANP32B DRG1 PPP1R7 COX5A PSMA3 SNRPG EIF4E2 ATOX1 PSMD9 PSMC1 SOD1 ATP6V0E1 CANX up
## MORF_DNMT1 0.0015432 0.0053283 0.6606167 2.834874 0 103 NUDC PPM1G EBNA1BP2 SRPK1 DNAJC11 SNRNP200 LMNB2 RAD23A CHAF1A CCT5 SSRP1 TXNL4A RUVBL2 SNRPA KXD1 DNMT1 KHSRP EIF3I TRRAP NONO NUDT1 PRKDC MCM2 TFDP1 DDX19B ZWINT HNRNPU SLBP RPIA SRRM1 CS FUS PDIA6 TCERG1 CDK11A TNPO3 SSBP1 SF3A3 GOT2 PRPF8 RAD54L ANP32A NUP188 GTF2A2 MCM3 PABPC4 CLPP HADH SRSF1 HNRNPA2B1 MRPS27 HNRNPM PPIE ZNF131 ESPL1 FH TARDBP BUB1B LRPPRC POLA2 SAFB IMMT AFG3L2 TYMS MCM5 NAE1 NASP DUT SREBF2 TCEA1 RFC4 KHDRBS1 up
## MORF_PRKAG1 0.0014347 0.0053283 0.6051563 2.817485 0 203 SLC4A2 DAP3 OTUB1 MTX1 BMS1 ALG3 SH2B1 TFAP4 ADAM15 PCGF1 EIF2B5 ATXN2L CIB1 TSTA3 BECN1 GOLGA3 PKMYT1 B4GALT3 SNRNP200 MFN2 MRPL28 TXLNA SRRT PSMD3 CYHR1 ILVBL GNL2 PRKCSH UBE3C BAHD1 CPSF4 AATF NELFB RUVBL2 KXD1 EIF3I PMM2 MRPL9 NCOR2 SGTA PRDX4 CSNK1D BPHL COPS6 KDM3B NONO NIPSNAP1 PSMD2 SDHA XPO6 PDXDC1 CAD PARN BRD8 TPR ILF2 DOCK3 DRAP1 MLEC TP53BP1 CSNK1G2 RPRD2 TMED1 PSMB6 YIF1A MPST PHB TOMM34 CS COQ9 POLR2A FANCG PABPN1 NUP62 BRD3 PARP2 MMS19 RPN2 NFRKB LSM12 MZF1 CHD3 PRPF8 SDR39U1 AHCYL1 NUP188 SLC25A11 RTCB PLIN3 TCOF1 MEA1 HUWE1 HNRNPA2B1 KPNA6 RAC1 ALDH4A1 PPP2R1A DDB1 LRPPRC SFSWAP ABR HSPA8 CTDNEP1 CCT4 AFG3L2 COX8A CLSTN1 OARD1 CSNK2A1 DRG1 POLR2C CETN3 HNRNPL EML3 DDX18 CANX SERP1 HLTF TCEA1 SEC23IP PRKAG1 NAP1L4 KHDRBS1 PARG up
## MORF_ANP32B 0.0014535 0.0053283 0.6074899 2.812495 0 183 EEF1D UBE2I EIF3C CTBP1 TUFM HDGF NDUFV1 RNPS1 PPM1G JTB CYC1 PDAP1 COMMD4 SNRNP200 SART1 LSM7 NCL SF3A2 RAD23A CBX3 PTBP1 HNRNPAB GNAS SNRPA KXD1 MRPL9 SF3B2 EIF3G CHD4 SNRPE ILF3 GNB2 CCT7 COPS6 NONO NUDT1 TRIM28 SDHA PARK7 MCM7 RSL1D1 RALY PSMB4 CCT2 HSPD1 NDUFA1 NDUFS3 HSP90AB1 DDOST HNRNPA1 BANF1 PPP1CA RPL36AL DDX49 TAF7 HNRNPUL1 COX6B1 SNRPB COX4I1 SSR2 FBL FUS COPE RPL24 SNRPD2 RPL10A PABPC1 RPLP2 CLNS1A RPL18 RPL30 FAU SMARCD2 COX7C UQCRH EEF2 RPS12 ERP29 HINT1 RPL14 AURKB COX5B UBE2L3 SF3A1 GANAB PUF60 XRCC6 BTF3 TARDBP PPP2R1A RPS24 URM1 SUMO3 HDAC1 SRSF9 EIF3H PCNA PSMD8 CTCF RPS6 RBMX ANP32B DRG1 NACA RPS27A PSMC1 SOD1 CANX ATXN10 TCEA1 KHDRBS1 MTDH EIF3K up
## MORF_IKBKG 0.0015337 0.0053283 0.6341892 2.796704 0 126 HSF4 OTUB1 MTX1 IGSF9B PVT1 SH2B1 ST14 ADAM15 PCGF1 CIB1 TSTA3 PKMYT1 B4GALT3 FDXR PSD4 PITPNM1 RABGGTA RPS6KB2 ILVBL RASSF7 PRKCSH BAHD1 HMG20B CRCP WDR62 GTF2F1 NELFB HMGXB3 TRA2A CSNK1D COPS6 KDM3B IGHMBP2 PARN DHRS1 LDB1 MCRS1 ARAF RPRD2 CASP2 CNPPD1 USP19 GRK6 DDX11 PHB POLR2A FANCG MCM3AP SETD1B KHNYN DRG2 NFRKB LSM12 GSK3A PML PMF1 DGCR11 IFT140 ORC1 TUBGCP2 ZNF592 PLIN3 TCOF1 AP2A2 MVK ALDH4A1 DDB1 SCAMP5 SFSWAP SLC6A9 SLC5A2 DIP2C CSNK2A1 MR1 SLC9A1 ZFPL1 HNRNPL EML3 CAMSAP1 up
## MORF_RAD54L 0.0015924 0.0053283 0.6657637 2.792871 0 88 BMS1 ALG3 NUDC PWP2 SRPK1 DNAJC11 PKMYT1 THOP1 TXLNA CHAF1A GNL2 SSRP1 RUVBL2 DNMT1 KHSRP EIF3I SGTA TRRAP XPO6 CAD PRKDC MCM2 TFDP1 DFFA ZWINT MLEC DDX46 SRRM1 CS POLR2A CDK11A TNPO3 PABPN1 NUP62 SSBP1 ARID3A MMS19 MZF1 GOT2 PRPF8 DDX39A RAD54L NUP188 THOC2 GTF2A2 PABPC4 TCOF1 HADH HNRNPA2B1 ZNF131 BUB1B LRPPRC SFSWAP SAFB IMMT CCT4 AFG3L2 up
## MORF_RPA2 0.0014684 0.0053283 0.6043620 2.784356 0 176 OTUB1 E2F4 MTX1 IGSF9B WDR18 ADAM15 ATXN2L MEN1 EIF6 PKMYT1 B4GALT3 SNRNP200 MFN2 FDXR THOP1 PSD4 TXLNA PITPNM1 TSFM PRKCSH TMED9 GTF2F1 AATF NELFB KXD1 EIF3I MRPL9 COPS6 KDM3B NONO NUDT1 DIAPH1 PSMD2 XPO6 CAD PRKDC PARN BRD8 MCM2 SMARCC2 ILF2 MCRS1 MLEC RPRD2 CASP2 CNPPD1 DDX49 OGDH MAP3K11 USP19 GRK6 DDX11 PHB SRRM1 CS COQ9 POLR2A FANCG KHNYN PABPN1 NUP62 PARP2 NFRKB LSM12 GSK3A PRPF8 RAD54L ORC1 NUP188 SMARCC1 GTF2A2 RTCB PLIN3 TCOF1 HNRNPA2B1 TIMM17A TAZ MVK PPIE ZNF131 CSK ELK1 ALDH4A1 RPN1 DDB1 LRPPRC POLA2 SFSWAP IMMT CTDNEP1 CCT4 AFG3L2 CLSTN1 CSNK2A1 DRG1 PPIF HNRNPL EML3 SREBF2 DDX18 SERP1 TCEA1 PRKAG1 ADSL NAP1L4 KHDRBS1 up
## MORF_MAP2K2 0.0015504 0.0053283 0.6383739 2.783971 0 117 SLC4A2 TBL3 AP3D1 RNPEP TUFM NDUFV1 PPM1G JTB CYC1 LSM4 SNRNP200 HAX1 RANGAP1 GPX4 TRAPPC3 RAD23A CCT5 TMED9 FIBP HNRNPAB IMPDH1 RUVBL2 SNRPA KXD1 EIF3I MRPL9 SF3B2 MAP2K2 SNRPE GNB2 CCT7 NONO NDUFS5 TRIM28 SDHA PARK7 IDH3B NDUFS3 DDOST BANF1 UBE2S TMEM147 PSMB2 DDX49 HNRNPUL1 DCTN2 CS COPE AKR7A2 SSBP1 FAM120A SLC3A2 SDHB NDUFC1 NUP188 GPI ERP29 COX5B POLR2I GANAB RAC1 PUF60 RHEB PPP2R1A RPN1 SRSF9 PSMD8 CTDNEP1 AFG3L2 COX8A DGKZ DRG1 SOD1 CANX ATXN10 TCEA1 KHDRBS1 MTDH EIF3K up
## MORF_GNB1 0.0013661 0.0053283 0.5731795 2.770019 0 274 EDC4 AP3D1 AK2 CTBP1 RNPEP NUDC GUSB TUFM NDUFV1 RNPS1 RNF44 ATXN2L PPM1G JTB SEC24C MGRN1 SNRNP200 THOP1 HAX1 TXLNA TRAPPC3 LSM7 NCL SF3A2 RAD23A CBX3 PTBP1 TMED9 HNRNPAB TXNL4A IMPDH1 RUVBL2 SND1 SNRPA KXD1 NDUFS2 DNMT1 KHSRP EIF3I MRPL9 MAP2K2 BAZ2A CHD4 NCOR2 SNRPE DDX19A ILF3 GNB2 CCT7 NONO NUDT1 DIAPH1 NDUFS5 TRIM28 SDHA PRRC2C PARK7 XPO6 RNF4 PRKDC IDH3B BRD8 MCM2 SMARCC2 DDX19B ILF2 TAX1BP1 DOCK3 DDOST MLEC UBE2S HNRNPU SLBP PSMB2 DDX49 RPIA MAP3K11 HNRNPUL1 SRRM1 CS PIN1 POLR2A FUS PDIA6 TNPO3 PABPN1 COPE AKR7A2 EIF3D SSBP1 DGUOK SUGP2 GOT2 PRPF8 SDHB NDUFC1 ANP32A UQCRH AHCYL1 EI24 GAK NUP188 SMARCC1 GTF2A2 OXA1L RTCB PABPC4 CLPP HADH ERP29 TOMM20 HNRNPA2B1 UBE2L3 TIMM17A HNRNPM SF3A1 GANAB PPIE ZNF131 CSK ESPL1 RHEB FH PKN1 TARDBP PPP2R1A UQCRC1 RPN1 LRPPRC HDAC1 POLA2 SRSF9 EIF3H SAFB IMMT CTDNEP1 AFG3L2 TYMS CLSTN1 up
## MORF_EI24 0.0015385 0.0053283 0.6273277 2.747670 0 119 ALG3 RNPEP NUDC LARP1 TUFM TM9SF4 NDUFV1 PPM1G CCT3 LSM4 DNAJC11 SEC24C SNRNP200 EIF4G1 HAX1 TRAPPC3 RAD23A CCT5 TMED9 HNRNPAB SSRP1 RUVBL2 SNRPA KXD1 NDUFS2 KHSRP NCOR2 PRDX4 SDHA PRKDC ALG8 DDX19B DOCK3 ZWINT MLEC UBE2S PSMB2 XPOT CS COQ9 SLC1A5 NUP62 AKR7A2 SSBP1 DGUOK FAM120A MFAP1 SLC3A2 GOT2 SDHB NDUFC1 EI24 AHSA1 CCNB1 GTF2A2 SRSF1 HNRNPA2B1 BUB1 POLR2I GLO1 GANAB RAC1 RHEB FH up
## MORF_NPM1 0.0015244 0.0053283 0.6091228 2.731224 0 149 EEF1D UBE2I HDGF RNPS1 JTB ENO1 NCL CBX3 GNAS SNRPE PPIA CCT7 COPS6 NONO RPL38 RPS2 PARK7 RPL37 CCT2 MRPL23 MAZ RPL11 HSPD1 HSP90AB1 RPL8 HNRNPA1 RPL13 RPLP1 RPL12 DDX49 RPL35 SNRPB RPS3 COX4I1 RPS5 RPL24 RPS27 RPLP0 EIF3D RPL27 RPL10A PABPC1 RPLP2 RPL27A RPL19 RPS16 RPL28 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPS28 FAU RPS29 RPL3 COX7C UQCRH RPS11 EEF2 RPS12 HINT1 RPL14 RPS14 PTMA RPL13A UBE2L3 RPS10 XRCC6 RPL29 RPL32 BTF3 UBC RPS24 CFL1 SUMO3 EIF3H RPS7 RPL9 RPS6 RPL23A RPS4X ANP32B RPL23 DRG1 NACA RPS15A RPS27A RPS8 up
## MORF_G22P1 0.0015038 0.0053283 0.6000525 2.723593 0 158 UBE2I AP3D1 EIF3C CTBP1 TUFM HDGF NDUFV1 RNPS1 PPM1G JTB CCT3 COMMD4 SNRNP200 LSM7 NCL RAD23A CBX3 MYL6B MAEA PTBP1 CDC37 TXNL4A IMPDH1 PRMT1 SNRPA KXD1 EIF3I NDUFAB1 EIF3G CHD4 SNRPE CCT7 NONO NUDT1 NDUFS5 TRIM28 PARK7 MCM7 IDH3B CCT2 ILF2 MRPL23 HSPD1 NDUFS3 HSP90AB1 HNRNPA1 DDX49 HNRNPUL1 COX6B1 SNRPB PSMB3 COX4I1 FBL FUS PDIA6 RPL24 EIF3D SNRPD2 TTC1 CLNS1A SDHB FAU COX7C UQCRH DHX9 AP1B1 RPL14 TOMM20 ACLY COX5B UBE2L3 POLR2I HNRNPM SF3A1 GANAB PUF60 XRCC6 BTF3 TARDBP SUMO3 HDAC1 SRSF9 EIF3H PCNA PSMD8 CTDNEP1 RBM14 RBMX ANP32B DRG1 up
## MORF_ARAF1 0.0015873 0.0053283 0.6703879 2.716690 0 73 HSF4 OTUB1 MTX1 IGSF9B PVT1 LYPLA2 LMTK2 ADAM15 BTBD2 B4GALT3 RABGGTA RASSF7 PRKCSH HMG20B GTF2F1 ACKR2 NELFB CACTIN FZR1 COPS6 IGHMBP2 DHRS1 PCGF2 PDPK1 CIZ1 LTK ARAF CNPPD1 TNK2 GRK6 DRG2 RPLP2 MAN2C1 GSK3A PML LPAR2 TUBGCP2 PLIN3 PTMA GRM4 MVK ALDH4A1 ARVCF RPS24 up
fgsea_plot(fgsea_res$res_c5, pathways_title='C5 GO genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## GO_RIBOSOME_BIOGENESIS 0.0013755 0.0195512 0.6377940 3.105867 0 259 RRNAD1 TBL3 RPUSD1 UTP14A NOC2L MYBBP1A DDX56 MTG2 WDR55 FAM207A MRPL20 NOL6 BMS1 MRPS2 TSR3 WDR18 ISG20L2 NOC4L RRP9 EBNA1BP2 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 EIF6 MALSU1 PWP2 PPAN RRP1 RPUSD2 NOM1 DHX37 DDX51 ERAL1 LAS1L PELP1 GNL3L SART1 URB1 MRTO4 KRI1 NHP2 GEMIN4 DDX27 NAT10 POP7 EXOSC6 NOP56 NLE1 NVL GNL2 DDX54 PIH1D1 IMP4 NPM3 AATF UTP3 VCX MRPL11 ERCC2 NOLC1 DDX31 NGDN TRMT112 PDCD11 MRPL36 FTSJ3 TSR1 MRPS7 ZNF622 RPL38 RRP1B RPS2 RPS21 DROSHA MPHOSPH10 RPP25 RSL1D1 PA2G4 GAR1 GTPBP4 EXOSC10 PAK1IP1 GTPBP10 NIP7 RPL11 C1QBP EXOSC2 MPV17L2 NSUN4 RPL12 METTL16 DDX49 RPL35 IMP3 HEATR1 URB2 RBFA RPLP0P6 RRP7A DHX30 FBL RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A TSR2 RPS16 RRP36 TFB2M NOP58 WDR74 DDX28 RPSA MRPS11 RPS28 YBEY RPL3 MRPL10 EXOSC1 RRN3 MDN1 NOL9 BYSL RPP38 UTP18 ERI3 RPL14 RPS14 NSUN5 BRIX1 ERI1 WDR3 BOP1 UTP6 RPS10 DCAF13 RPL26L1 RRP15 RPS24 ZNHIT6 RPL26 ESF1 RPS7 RPL35A HEATR3 RPS6 LYAR WDR12 RPL23A NUP88 LTV1 TRMT61B up
## GO_MITOCHONDRIAL_PROTEIN_COMPLEX 0.0014006 0.0195512 0.6441491 3.074560 0 217 MRPS34 MRPL55 MRPL24 MRPL4 DAP3 MRPL20 MTX1 FOXRED1 MRPS26 NDUFS6 MRPL33 NDUFS8 MRPS2 MRPS15 POLRMT NDUFV1 CYC1 MALSU1 CHCHD10 MRPL12 DNAJC11 MRPL14 MRPL28 TIMM50 AGK MT-CYB ANKZF1 NDUFB10 NDUFB2 NDUFB7 MRPS33 MRPS18A PMPCA MT-ND4L ROMO1 SPG7 MRPS6 MT-ND3 MRPL11 MT-ND2 TOMM40 MRPL27 NDUFS2 MT-ATP6 MRPL41 MRPL9 NDUFAB1 MRPL21 MCCC2 MRPL49 MT-ND4 MRPL36 NDUFS5 MRPS7 SDHA MRPS5 MRPL52 MT-ATP8 MT-ND5 TIMM13 MRPL17 MT-ND1 BCS1L CHCHD3 BCKDK MRPL23 MRPL37 MRPL51 BAX TOMM40L NDUFA1 NDUFS3 MPV17L2 MRPL48 MRPS12 NSUN4 COA3 MICU1 NDUFV3 UQCRQ NDUFA13 MRPS35 NDUFS7 NDUFA11 NDUFB9 MRPL2 COX4I1 MRPL38 PNPT1 MRPS16 MRPL3 TIMM8B TOMM22 MRPL34 MCU MRPS21 TOMM7 GRPEL1 TIMM9 MRPS11 TIMM10 SDHB NDUFC1 MRPL10 UQCRH MT-CO1 PAM16 MRPS17 NDUFB1 TOMM20 MRPS27 UQCR10 C12orf65 MTX2 TIMM17A POLG CHCHD6 MRPL15 UQCRC1 MRPL54 NDUFA4 C15orf48 IMMT MCCC1 UQCRC2 NDUFA2 AFG3L2 CLPX MRPL43 MRPS28 NDUFA10 PPIF MRPL44 COX5A SDHC VDAC1 up
## GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 0.0013387 0.0195512 0.6037857 3.036003 0 382 RRNAD1 TBL3 EIF3B RPUSD1 UTP14A NOC2L NOL3 PRPF6 MYBBP1A DDX56 CD2BP2 MTG2 WDR55 FAM207A ADAR MRPL20 NOL6 EIF3C BMS1 MRPS2 TSR3 DDX23 USP39 WDR18 ISG20L2 NOC4L RRP9 EBNA1BP2 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 EIF6 MALSU1 PWP2 PPAN PRMT5 RRP1 SRPK1 RPUSD2 LSM4 NOM1 SNRNP200 DHX37 DDX51 ERAL1 LAS1L PELP1 PRMT7 GNL3L SART1 URB1 MRTO4 KRI1 NHP2 GEMIN4 DDX27 SF3A2 NAT10 POP7 CELF5 EXOSC6 RUVBL1 NOP56 NLE1 NVL GNL2 DDX54 PIH1D1 IMP4 NPM3 PRPF19 AATF UTP3 TXNL4A VCX RUVBL2 XAB2 MRPL11 ERCC2 NOLC1 EIF3I DDX31 NGDN EIF3G TRMT112 SNRPE PDCD11 MRPL36 FTSJ3 TSR1 CPSF6 MRPS7 ZNF622 RPL38 RRP1B EIF3CL RPS2 RPS21 DROSHA MPHOSPH10 RPP25 RSL1D1 PA2G4 GAR1 TARBP2 GTPBP4 EXOSC10 PAK1IP1 GTPBP10 NIP7 RPL11 C1QBP EXOSC2 HSP90AB1 MPV17L2 NSUN4 RPL12 CPSF7 METTL16 DDX49 RPL35 IMP3 HEATR1 URB2 RBFA RPLP0P6 SNRPB PRPF39 SNRPC RRP7A DHX30 AAR2 FBL GEMIN2 RPS5 RPS15 RPL24 RPS27 RPLP0 EIF3D SNRPD2 RPL27 RPL10A TSR2 SF3A3 CLNS1A RPS16 RRP36 POLR2D TFB2M NOP58 AGO2 WDR74 DDX28 RPSA MRPS11 GEMIN5 PRPF8 RPS28 YBEY RPL3 MRPL10 EIF3A EXOSC1 RRN3 MDN1 NOL9 SNRPF BYSL DHX9 RPP38 UTP18 SRSF1 ERI3 RPL14 RPS14 NSUN5 RPL13A BRIX1 ERI1 WDR3 SNRPD3 BOP1 SF1 UTP6 SF3A1 RPS10 DCAF13 RPL26L1 GEMIN6 RRP15 SNRPD1 CELF1 RPS24 ZNHIT6 TGS1 RPL26 SFSWAP SRSF9 EIF3H PRPF18 MCTS1 ESF1 RPS7 RPL35A HEATR3 SRPK2 RPS6 ATR LYAR WDR12 RPL23A LUC7L NUP88 RBMX LTV1 TRMT61B CELF4 up
## GO_RIBONUCLEOPROTEIN_COMPLEX 0.0012210 0.0195512 0.5794230 3.035952 0 630 SNRNP25 MRPS34 TBL3 TERC MRPL55 EIF3B MRPL24 UTP14A NOC2L PRPF6 SMG5 CD2BP2 MRPL4 PKP3 DAP3 FAM207A ADAR MRPL20 MRPS26 PABPC1L NOL6 EIF3C BMS1 MRPL33 MRPS2 DDX23 USP39 MRPS15 LARP1 NOC4L SNORA74A RRP9 DDX41 RPL39L EBNA1BP2 RRS1 NOB1 NOP14 PES1 EIF6 MALSU1 PWP2 PPAN SRRM2 RRP1 MRPL12 LSM4 SNRNP200 MRPL14 MRPL28 EIF4G1 LAS1L PNN GNL3L SART1 MRTO4 ALYREF KRI1 NHP2 GEMIN4 MRPS33 LSM7 NCL SF3A2 NAT10 GTF3C1 POP7 CELF5 DIS3L2 RUVBL1 MRPS18A NOP56 NVL PIH1D1 IMP4 XPO5 MRPS6 PRPF19 UTP3 HNRNPAB RBMX2 TXNL4A RUVBL2 SND1 XAB2 MRPL11 MRPL27 SNRPA NOLC1 PPP1R8 EIF3I MRPL41 MRPL9 CACTIN SF3B2 NDUFAB1 MRPL21 NGDN TRA2A MRPL49 EIF3G HTATSF1 DAZAP1 SNRPE SF3B3 ILF3 PSMA6 PDCD11 MRPL36 UPF1 FTSJ3 TSR1 CPSF6 MRPS7 ZNF622 MRPS5 MRPL52 RMRP RPL38 RRP1B EIF3CL RPS2 MRPL17 RPS21 ZMAT2 U2AF2 EFTUD2 IGHMBP2 MPHOSPH10 RPP25 RPL36 LSM5 RSL1D1 RALY FXR2 RPL37 GAR1 TARBP2 ILF2 MRPL23 TERT SMG7 FBXW9 SRP68 NIP7 RPL11 MRPL37 CWC25 MRPL51 POP1 SRA1 RPL8 MCRS1 HNRNPA1 RPL13 RPLP1 MPV17L2 ZNF830 HNRNPU RNF113A MRPL48 SLBP WDR83 MRPS12 NSUN4 RPL12 RPL36AL RPL35 IMP3 HEATR1 AKAP8L PABPC3 RBM28 SNRNP70 SRRM1 RBM42 DHX38 MRPS35 EEFSEC RPLP0P6 LSM10 SNRPB RPS3 PRPF39 MRPL2 SNRPC RRP7A AAR2 MRPL38 RPL37A FBL PNPT1 MRPS16 MRPL3 FUS MKRN3 GEMIN2 PABPN1 RPS5 NUP62 RPS15 RPL24 RPS27 RPLP0 EIF3D SNRPD2 RPL27 RPL10A PABPC1 TEP1 RPLP2 RPL27A SF3A3 MRPL34 RPL19 RPS16 SNRNP40 RNPC3 SRP54 MRPS21 RRP36 DHX8 RPL28 RPL39 RPL41 CALR RPL22 RPS20 NOP58 SNRNP35 RPL18 MFAP1 RPL31 AGO2 RPL18A WDR74 RPL30 ZMAT5 CSNK1A1 BUD31 RPSA GAPDH MRPS11 PRPF8 RPS28 RPS29 RPL3 PPIH PHF5A MRPL10 EIF3A RPS11 EEF2 DDX53 RPS12 SNRPF BYSL LARP4B DHX9 ZFP36L1 PABPC4 CCDC12 TFIP11 RPP38 UTP18 SRSF1 MRPS17 HNRNPF RPL14 RPS14 ELAVL1 RPL13A HNRNPA2B1 MRPS27 C12orf65 ERI1 WDR3 SF3B5 SNRPD3 BOP1 SF1 UTP6 PRPF4 HNRNPM DHX29 SF3A1 SUGP1 SLIRP PPIE PPIL1 RPS10 DCAF13 RPL26L1 RPL29 RHEB TRIM21 EIF2AK4 RPL32 JAKMIP1 BTF3 U2AF1L4 RRP15 SNRPD1 TTF2 CELF1 TARDBP RPS24 MRPL15 MRPL54 ZNHIT6 TGS1 BRCA1 CDC5L RPL26 LRPPRC EIF3H MSI1 PRPF18 HSPA8 MCTS1 RPS7 SNIP1 RPL35A RPL9 RBM14 WRAP53 MRPL43 RBM23 RPS6 WDR12 RPL23A LUC7L RBMX RPS4X PDCD7 LTV1 NAA38 HNRNPA0 MRPS28 IGF2BP1 CELF4 UBA52 CIRBP RPL23 DRG1 MRPL44 CELF3 SNRPG MAGOH RPS15A EIF2D RPS27A RPS26 RPS8 ACTN4 NOP10 up
## GO_RIBOSOMAL_SUBUNIT 0.0014793 0.0195512 0.6574170 3.033795 0 172 MRPS34 MRPL55 MRPL24 MRPL4 DAP3 MRPL20 MRPS26 MRPL33 MRPS2 MRPS15 RPL39L MALSU1 MRPL12 MRPL14 MRPL28 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 NDUFAB1 MRPL21 MRPL49 MRPL36 MRPS7 MRPS5 MRPL52 RPL38 RPS2 MRPL17 RPS21 RPL36 FXR2 RPL37 MRPL23 RPL11 MRPL37 MRPL51 RPL8 RPL13 RPLP1 MPV17L2 MRPL48 MRPS12 NSUN4 RPL12 RPL36AL RPL35 MRPS35 RPLP0P6 RPS3 MRPL2 MRPL38 RPL37A MRPS16 MRPL3 RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A MRPL34 RPL19 RPS16 MRPS21 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA MRPS11 RPS28 RPS29 RPL3 MRPL10 RPS11 RPS12 MRPS17 RPL14 RPS14 RPL13A MRPS27 C12orf65 RPS10 RPL26L1 RPL29 RPL32 RPS24 MRPL15 MRPL54 RPL26 MCTS1 RPS7 RPL35A RPL9 MRPL43 RPS6 RPL23A RPS4X MRPS28 UBA52 RPL23 MRPL44 RPS15A EIF2D RPS27A RPS26 RPS8 up
## GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 0.0014903 0.0195512 0.6667527 3.028009 0 152 MRPS34 MRPL55 MRPL24 MRPL4 DAP3 MRPL20 MRPL33 MRPS2 MRPS15 RPL39L MRPL12 MRPL14 MRPL28 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 MRPL21 MRPL49 MRPL36 MRPS7 MRPS5 MRPL52 RPL38 RPS2 MRPL17 RPS21 RPL36 RPL37 MRPL23 RPL11 MRPL37 MRPL51 RPL8 RPL13 RPLP1 MRPS23 MRPS12 RPL12 RPL36AL RPL35 MRPS35 RPLP0P6 RPS3 MRPL2 RPL37A MRPS16 MRPL3 RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A MRPL34 RPL19 RPS16 MRPS21 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA MRPS11 RPS28 RPS29 RPL3 MRPS25 MRPL10 RPS11 RPS12 MRPS17 RPL14 RPS14 RPL13A RPS10 RPL26L1 RPL29 RPL32 RPS24 MRPL15 MRPL54 RPL26 RPS7 RPL35A RPL9 MRPL43 RPS6 RPL23A RPS4X UBA52 RPL23 RPS15A RPS27A RPS26 RPS8 up
## GO_NCRNA_PROCESSING 0.0013643 0.0195512 0.6087856 3.026194 0 325 RRNAD1 TYW1 TBL3 DUS1L RPUSD1 UTP14A PUSL1 POLR3K GTPBP3 DDX56 WDR55 CSTF2 TRPT1 FAM207A INTS1 ADAR WDR4 QTRT1 METTL1 TRMT1 NOL6 BMS1 TSR3 WDR18 ISG20L2 NOC4L RRP9 DGCR8 AARS2 EBNA1BP2 TSEN54 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 RRP1 RPUSD2 DHX37 DDX51 LAS1L CTU2 PELP1 SRRT SART1 URB1 MRTO4 KRI1 TRMT61A USB1 NHP2 GEMIN4 NSUN2 DDX27 TRMT12 TRMT44 NAT10 POP7 EXOSC6 NOP56 NVL DUS3L DDX54 INTS5 PIH1D1 IMP4 CPSF4 NPM3 TRMU PUS7 PUS1 UTP3 TRMT2B CDK5RAP1 TARBP1 ERCC2 NOLC1 NGDN TRMT112 CTU1 RPUSD4 ADAT1 PDCD11 FTSJ3 TSR1 ADAT3 RRP1B RPS2 RPS21 DROSHA MPHOSPH10 RPP25 ELAC2 RSL1D1 PARN METTL3 PA2G4 GAR1 TARBP2 GTPBP4 EXOSC10 METTL2B ANKRD16 RPL11 POP1 EXOSC2 METTL2A RNF113A NSUN4 METTL16 DDX49 RPL35 IMP3 HEATR1 RBFA SEPHS2 RRP7A DUS2 FBL TUT1 RPS15 RPS27 RPL27 TRMT6 RPL10A TSR2 INTS7 RPS16 PTCD1 RRP36 TFB2M NOP58 GRSF1 AGO2 WDR74 TRIT1 MRPS11 RPS28 YBEY EXOSC1 MDN1 NOL9 BYSL SMAD3 RTCB RPP38 UTP18 ERI3 RPL14 RPS14 NSUN5 HNRNPA2B1 ERI1 WDR3 KTI12 BOP1 UTP6 DCAF13 RRP15 INTS4 RPS24 URM1 LCMT2 ZNHIT6 RPL26 C9orf64 TRMT5 ESF1 RPS7 PUS3 RPL35A TP53RK RPS6 LYAR WDR12 FARS2 ZBTB8OS TRMT61B CPSF1 up
## GO_RIBOSOME 0.0014124 0.0195512 0.6305010 2.994996 0 211 MRPS34 MRPL55 MRPL24 AURKAIP1 MTG2 MRPL4 DAP3 MRPL20 MRPS26 MRPL33 MRPS2 MRPS15 LARP1 RPL39L MALSU1 MRPL12 MRPL14 MRPL28 GADD45GIP1 RRBP1 CHCHD1 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 NDUFAB1 MRPL21 MRPL49 MRPL36 MRPS7 MRPS5 MRPL52 DNAJC21 RPL38 RPS2 APEX1 MRPL17 RPS21 RPL36 FXR2 RPL37 MRPL23 SRP68 RPL11 MRPL37 MRPL51 RPL8 RPL13 RPLP1 MPV17L2 MRPS23 MRPL48 MRPS12 NSUN4 RPL12 RPL36AL RPL35 MRPS35 RPLP0P6 RPS3 MRPL2 MRPL38 RPL37A PNPT1 MRPS16 MRPL3 RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A MRPL34 RPL19 RPS16 MRPS21 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA MRPS11 RPS28 RPS29 RPL3 MRPS25 MRPL10 RPS11 EEF2 RPS12 LARP4B DHX9 MRPS17 RPL14 RPS14 RPL13A MRPS27 C12orf65 SF1 MTG1 RPS10 RPL26L1 RPL29 EIF2AK4 RPL32 BTF3 METTL17 RPS24 MRPL15 MRPL54 RPL26 EIF3H PTCD3 MCTS1 RPS7 RPL35A RPL9 MRPL43 APOD RPS6 RPL23A RPS4X MRPS28 UBA52 RPL23 MRPL44 RPS15A EIF2D RPS27A RPS26 RPS8 up
## GO_NCRNA_METABOLIC_PROCESS 0.0013280 0.0195512 0.5858848 2.950351 0 396 RRNAD1 TYW1 TBL3 DUS1L RPUSD1 UTP14A PUSL1 POLR3K GTPBP3 AIMP2 DDX56 FARSA WDR55 CSTF2 TARS2 TRPT1 FAM207A INTS1 ADAR WDR4 QTRT1 METTL1 TRMT1 NOL6 BMS1 TSR3 WDR18 ISG20L2 NOC4L EARS2 RRP9 DGCR8 HRAS AARS2 EBNA1BP2 TSEN54 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 RRP1 RPUSD2 DHX37 DDX51 LAS1L CTU2 PELP1 SRRT HARS2 TDRKH SART1 URB1 MRTO4 KRI1 TRMT61A USB1 NHP2 GEMIN4 NSUN2 DDX27 TRMT12 TRMT44 NAT10 POP7 EXOSC6 DIS3L2 NOP56 NVL DUS3L DDX54 INTS5 PIH1D1 IMP4 XPO5 CPSF4 NPM3 TRMU PUS7 PUS1 UTP3 TRMT2B SND1 CDK5RAP1 KHSRP TARBP1 ERCC2 NOLC1 NGDN TRMT112 CTU1 RPUSD4 ADAT1 PDCD11 FTSJ3 TSR1 ADAT3 RRP1B RPS2 TDRD1 RPS21 DROSHA NARS2 MPHOSPH10 RPP25 ELAC2 RSL1D1 PARN METTL3 PA2G4 GAR1 TARBP2 GTPBP4 EXOSC10 METTL2B MARS2 ANKRD16 RELA RPL11 MAEL POP1 EXOSC2 METTL2A RNF113A FARSB AARSD1 NSUN4 METTL16 DDX49 IARS2 RPL35 IMP3 HEATR1 RBFA SEPHS2 RRP7A DUS2 GPAT2 FBL PNPT1 TUT1 RPS15 RPS27 RPL27 TRMT6 RPL10A MEPCE TSR2 INTS7 RPS16 PTCD1 RRP36 TFB2M DTD1 NOP58 GRSF1 AGO2 WDR74 TRIT1 MRPS11 SLFN13 AIMP1 RPS28 PARS2 YBEY EXOSC1 ZC3H12A MDN1 NOL9 BYSL SMAD3 RTCB PELO RPP38 UTP18 ERI3 RPL14 RPS14 NSUN5 HNRNPA2B1 ERI1 WDR3 KTI12 BOP1 UTP6 PPA1 DCAF13 RRP15 INTS4 RPS24 URM1 DIS3L LCMT2 YARS2 ZNHIT6 RPL26 C9orf64 TRMT5 LARS2 ESF1 RPS7 PUS3 RPL35A TP53RK RPS6 LYAR WDR12 DALRD3 FARS2 ZBTB8OS TRMT61B CPSF1 up
## GO_RRNA_METABOLIC_PROCESS 0.0014388 0.0195512 0.6263565 2.947088 0 195 RRNAD1 TBL3 RPUSD1 UTP14A DDX56 WDR55 FAM207A NOL6 BMS1 TSR3 WDR18 ISG20L2 NOC4L RRP9 EBNA1BP2 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 RRP1 RPUSD2 DHX37 DDX51 LAS1L PELP1 SART1 URB1 MRTO4 KRI1 NHP2 GEMIN4 DDX27 NAT10 POP7 EXOSC6 NOP56 NVL DDX54 PIH1D1 IMP4 NPM3 UTP3 ERCC2 NOLC1 NGDN TRMT112 PDCD11 FTSJ3 TSR1 RRP1B RPS2 RPS21 DROSHA MPHOSPH10 RPP25 RSL1D1 PA2G4 GAR1 GTPBP4 EXOSC10 RPL11 EXOSC2 NSUN4 METTL16 DDX49 RPL35 IMP3 HEATR1 RBFA RRP7A FBL RPS15 RPS27 RPL27 RPL10A TSR2 RPS16 RRP36 TFB2M NOP58 WDR74 MRPS11 SLFN13 RPS28 YBEY EXOSC1 MDN1 NOL9 BYSL PELO RPP38 UTP18 ERI3 RPL14 RPS14 NSUN5 ERI1 WDR3 BOP1 UTP6 DCAF13 RRP15 RPS24 DIS3L ZNHIT6 RPL26 ESF1 RPS7 RPL35A RPS6 LYAR WDR12 up
## GO_MITOCHONDRIAL_GENE_EXPRESSION 0.0014970 0.0195512 0.6515770 2.946212 0 149 TBRG4 MRPS34 MRPL55 MRPL24 AURKAIP1 MTG2 MRPL4 TARS2 DAP3 MRPL20 MRPS26 MRPL33 MRPS2 MRPS15 TUFM POLRMT EARS2 AARS2 MALSU1 CHCHD10 MRPL12 MRPL14 MRPL28 TRUB2 ERAL1 GADD45GIP1 UQCC2 CHCHD1 MRPS33 MRPS18A TSFM MRPS6 PUS1 CDK5RAP1 MRPL11 MRPL27 MRPL41 MRPL9 SHMT2 MRPL21 MRPL49 RPUSD4 MRPL36 MRPS7 MRPS5 MRPL52 MRPL17 ELAC2 MRPL23 MRPL37 MRPL51 C1QBP MPV17L2 MRPS23 MRPL48 MRPS12 NSUN4 COA3 IARS2 MRPS35 MRPL2 MRPL38 PNPT1 MRPS16 MRPL3 MRPL34 MRPS21 TFB2M FASTKD5 TRIT1 MRPS11 UQCC1 MRPS25 MRPL10 OXA1L FASTKD3 MRPS17 NOA1 MRPS27 MTG1 SLC25A33 MRPL15 MRPL54 YARS2 LRPPRC TRMT5 LARS2 PTCD3 up
## GO_VIRAL_GENE_EXPRESSION 0.0014599 0.0195512 0.6248648 2.917477 0 185 EIF3B TRIM11 SMARCA4 POLR2J USF1 TFAP4 NELFCD NELFA POLR2L POLR2H SUPT5H PTBP1 GTF2F1 NELFB NUP205 EIF3G PSMC3 POLR2E RPL38 RRP1B RPS2 AAAS RPS21 RPL36 NUP210 RPL37 NUP107 TARBP2 TPR RPL11 RPL8 POLR2F RPL13 RPLP1 TRIM62 RPL12 RPL35 NUP93 RPS3 RPL37A POLR2A SMARCB1 NUP85 RPS5 NUP62 RPS15 RPL24 RPS27 RPLP0 EIF3D RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 POLR2D RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 RPS29 RPL3 TRIM14 RSF1 EIF3A RPS11 NUP188 RPS12 DHX9 MON1B SEC13 RPL14 RPS14 TRIM8 RPL13A POLR2I RPS10 RPL29 CTDP1 TRIM21 NUP214 EIF2AK4 RPL32 POU2F3 TARDBP RPS24 RPL26 POM121C HDAC1 NUP133 MCTS1 RPS7 RPL35A RPL9 EP300 RPS6 RAE1 FURIN RPL23A NUP88 RPS4X UBA52 RPL23 HPN NUP155 POLR2C RPS15A EIF2D RPS27A RPS26 RPS8 up
## GO_MITOCHONDRIAL_TRANSLATION 0.0015015 0.0195512 0.6565539 2.905372 0 127 MRPS34 MRPL55 MRPL24 AURKAIP1 MTG2 MRPL4 TARS2 DAP3 MRPL20 MRPS26 MRPL33 MRPS2 MRPS15 TUFM EARS2 AARS2 MALSU1 MRPL12 MRPL14 MRPL28 TRUB2 ERAL1 GADD45GIP1 UQCC2 CHCHD1 MRPS33 MRPS18A TSFM MRPS6 CDK5RAP1 MRPL11 MRPL27 MRPL41 MRPL9 SHMT2 MRPL21 MRPL49 RPUSD4 MRPL36 MRPS7 MRPS5 MRPL52 MRPL17 MRPL23 MRPL37 MRPL51 C1QBP MPV17L2 MRPS23 MRPL48 MRPS12 NSUN4 COA3 IARS2 MRPS35 MRPL2 MRPL38 MRPS16 MRPL3 MRPL34 MRPS21 MRPS11 UQCC1 MRPS25 MRPL10 OXA1L FASTKD3 MRPS17 NOA1 MRPS27 MTG1 MRPL15 MRPL54 YARS2 LRPPRC LARS2 PTCD3 up
## GO_LARGE_RIBOSOMAL_SUBUNIT 0.0015267 0.0195512 0.6679827 2.890909 0 108 MRPL55 MRPL24 MRPL4 MRPL20 MRPL33 RPL39L MALSU1 MRPL12 MRPL14 MRPL28 MRPS18A MRPL11 MRPL27 MRPL41 MRPL9 NDUFAB1 MRPL21 MRPL49 MRPL36 MRPL52 RPL38 MRPL17 RPL36 FXR2 RPL37 MRPL23 RPL11 MRPL37 MRPL51 RPL8 RPL13 RPLP1 MPV17L2 MRPL48 NSUN4 RPL12 RPL36AL RPL35 RPLP0P6 MRPL2 MRPL38 RPL37A MRPL3 RPL24 RPLP0 RPL27 RPL10A RPLP2 RPL27A MRPL34 RPL19 RPL28 RPL39 RPL41 RPL22 RPL18 RPL31 RPL18A RPL30 RPL3 MRPL10 RPL14 RPL13A C12orf65 RPL26L1 RPL29 RPL32 MRPL15 MRPL54 RPL26 RPL35A RPL9 MRPL43 RPL23A UBA52 RPL23 MRPL44 up
## GO_TRANSLATIONAL_TERMINATION 0.0015244 0.0195512 0.6700105 2.885758 0 100 MRPS34 MRPL55 MRPL24 AURKAIP1 MRPL4 DAP3 APEH MRPL20 JMJD4 MRPS26 MRPL33 MRPS2 MRPS15 MRPL12 MRPL14 MRPL28 ERAL1 GADD45GIP1 CHCHD1 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 MRPL21 MRPL49 TRMT112 MRPL36 UPF1 MRPS7 MRPS5 MRPL52 MRPL17 GSPT1 MRPL23 MRPL37 MRPL51 MRPS23 MRPL48 MRPS12 GLE1 EIF5A MRPS35 MRPL2 MRPL38 MRPS16 MRPL3 MRPL34 MRPS21 MRPS11 MRPS25 MRPL10 OXA1L MRPS17 MRPS27 C12orf65 up
## GO_RNA_PROCESSING 0.0011806 0.0195512 0.5373759 2.862148 0 817 TBRG4 SSU72 SNRNP25 RRNAD1 TYW1 TBL3 DUS1L RPUSD1 RNF40 UTP14A FASTK PUSL1 POLR3K NOL3 PRPF6 GTPBP3 DDX56 AURKAIP1 CD2BP2 WDR55 CSTF2 THOC6 TRPT1 FAM207A INTS1 ADAR POLR2J WDR4 QTRT1 METTL1 TRMT1 PABPC1L NOL6 BMS1 TSR3 IWS1 DDX23 USP39 EGFR WDR18 ISG20L2 NOC4L RNPS1 RRP9 DGCR8 DDX41 AARS2 EBNA1BP2 ZC3H3 TSEN54 RRS1 PRCC TRMT2A NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 PRMT5 SRRM2 RRP1 SRPK1 RPUSD2 RP9 LSM4 SNRNP200 DHX37 DDX51 TRUB2 LAS1L POLR2L CTU2 POLR2H PELP1 SCNM1 PNN PRMT7 SRRT SCAF1 ESRP2 CDK13 SART1 URB1 MRTO4 ALYREF KRI1 TRMT61A USB1 NHP2 GEMIN4 NSUN2 DDX27 TRMT12 LSM7 TRMT44 NCL DDX42 SF3A2 NAT10 SUPT5H POP7 CELF5 EXOSC6 NOP56 NVL DUS3L DCPS DDX54 INTS5 PTBP1 TP53 CDK11B PIH1D1 IMP4 CPSF4 NPM3 TRMU PUS7 PRPF19 PUS1 GTF2F1 UTP3 CMTR1 RBMX2 TXNL4A TRMT2B XAB2 CDK5RAP1 SNRPA CHERP KHSRP TARBP1 ERCC2 NOLC1 PPP1R8 ZC3H7B CACTIN SF3B2 BRDT MAP2K2 NGDN TRA2A HTATSF1 DAZAP1 TRMT112 CTU1 RPUSD4 ADAT1 NCOR2 SNRPE SF3B3 PHRF1 PDCD11 POLR2E THRAP3 FTSJ3 NONO TSR1 CPSF6 ADAT3 RMRP THOC3 RRP1B RPS2 ACIN1 CLK3 RPS21 ZMAT2 U2AF2 SUPT6H CDK12 DROSHA EFTUD2 MPHOSPH10 RPP25 LSM5 ELAC2 RSL1D1 RALY PARN FXR2 METTL3 PA2G4 GAR1 TARBP2 GTPBP4 EXOSC10 METTL2B MNAT1 UPF3B ANKRD16 TERT SRSF4 RPL11 CWC25 POP1 C1QBP EXOSC2 METTL2A HNRNPA1 POLR2F ZNF830 HNRNPU RNF113A SLBP RPRD2 WDR83 ESRP1 NSUN4 WDR33 SYMPK CPSF7 METTL16 SLTM DDX49 RPL35 IMP3 HEATR1 HNRNPUL1 AKAP8L RBM28 RBFA SEPHS2 CLASRP SNRNP70 DDX46 SRRM1 RBM42 DHX38 PAF1 LSM10 SNRPB PRPF39 ERN1 SNRPC RRP7A DUS2 AAR2 POLR2A FBL PNPT1 TUT1 FUS GEMIN2 CDK11A PABPN1 RPS15 RPS27 SNRPD2 RPL27 TRMT6 RPL10A TSR2 PABPC1 INTS7 SF3A3 CLNS1A RPS16 ERCC3 SNRNP40 RPRD1B PTCD1 RNPC3 RRP36 POLR2D DHX8 TFB2M FASTKD5 SUGP2 NOP58 SNRNP35 GRSF1 MFAP1 AGO2 WDR74 ZMAT5 BUD31 TRIT1 MRPS11 RBM15 GEMIN5 PRPF8 RPS28 ZC3H7A DDX39A YBEY PAN2 PPIH PHF5A AHCYL1 EXOSC1 ZC3H12A RBM19 MDN1 NOL9 SNRPF BYSL THOC2 SMAD3 CCNB1 DHX9 RTCB ZFP36L1 PABPC4 TFIP11 RPP38 UTP18 SRSF1 ERI3 HNRNPF RPL14 RPS14 NSUN5 ELAVL1 HNRNPA2B1 ERI1 WDR3 KTI12 SF3B5 SNRPD3 BOP1 SF1 UTP6 PRPF4 POLR2I HNRNPM SF3A1 SUGP1 PPP1R9B PPIE PUF60 MAP2K1 PPIL1 DCAF13 ZBTB7A PRDX6 HABP4 LEO1 GEMIN6 U2AF1L4 RRP15 SNRPD1 TTF2 CELF1 INTS4 TARDBP PPP2R1A RPS24 URM1 LCMT2 ZNHIT6 TGS1 CDC5L RPL26 C9orf64 SFSWAP SRSF9 TRMT5 PRPF18 PUM1 HSPA8 SAFB ESF1 RPS7 SNIP1 CHTOP PUS3 CSTF1 RPL35A CCAR2 ZC3H11A A1CF RBM23 TP53RK POLDIP3 SRPK2 RPS6 LYAR WDR12 FARS2 THOC5 LUC7L ZBTB8OS RBMX PDCD7 PQBP1 HNRNPA0 TRMT61B CPSF1 RPUSD3 CELF4 CIRBP WDR43 MRPL44 CELF3 TSN SNRPG ZMPSTE24 MAGOH POLR2C RNASEL ARL6IP4 RPS26 GEMIN7 RNF20 RPS8 TSEN15 NOP10 IK SON ISG20 MOCS3 UBL5 up
## GO_TRANSLATIONAL_ELONGATION 0.0014948 0.0195512 0.6473678 2.854839 0 125 MRPS34 MRPL55 MRPL24 AURKAIP1 EEF1D MRPL4 DAP3 ZNF598 MRPL20 MRPS26 MRPL33 MRPS2 DPH2 MRPS15 TUFM GTPBP2 MRPL12 MRPL14 MRPL28 ERAL1 GADD45GIP1 CHCHD1 MRPS33 MRPS18A TSFM EEF1A2 MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 MRPL21 DPH1 MRPL49 DPH7 MRPL36 MRPS7 MRPS5 MRPL52 MRPL17 MRPL23 MRPL37 MRPL51 TRNAU1AP RPLP1 MRPS23 MRPL48 MRPS12 EIF5A MRPS35 EEFSEC MRPL2 EEF2K MRPL38 MRPS16 MRPL3 GTPBP1 RPLP2 MRPL34 MRPS21 RPL30 MRPS11 MRPS25 MRPL10 EEF2 OXA1L MRPS17 MRPS27 up
## GO_PRERIBOSOME 0.0015873 0.0195512 0.7028282 2.826535 0 71 TBL3 UTP14A NOC2L FAM207A NOL6 BMS1 NOC4L RRP9 EBNA1BP2 RRS1 NOB1 NOP14 PES1 EIF6 PWP2 PPAN RRP1 LAS1L MRTO4 KRI1 NOP56 IMP4 UTP3 NGDN PDCD11 FTSJ3 TSR1 ZNF622 RRP1B MPHOSPH10 RSL1D1 FBXW9 NIP7 IMP3 HEATR1 RRP7A FBL RRP36 NOP58 WDR74 BYSL UTP18 WDR3 BOP1 UTP6 DCAF13 RRP15 up
## GO_RIBOSOME_ASSEMBLY 0.0016807 0.0195512 0.7476193 2.824301 0 52 MRPL20 MRPS2 RRS1 NOP2 EIF6 PWP2 PPAN ERAL1 MRTO4 NLE1 VCX MRPL11 MRPS7 RPL38 NIP7 RPL11 C1QBP MPV17L2 NSUN4 RPL12 RPLP0P6 RRP7A DHX30 RPS5 RPS15 RPL24 RPS27 RPLP0 DDX28 RPSA MRPS11 RPS28 RPL3 MDN1 RPS14 BRIX1 BOP1 RPS10 up
## GO_ORGANELLAR_RIBOSOME 0.0015974 0.0195512 0.6825977 2.814979 0 83 MRPS34 MRPL55 MRPL24 MTG2 MRPL4 DAP3 MRPL20 MRPS26 MRPL33 MRPS2 MRPS15 MALSU1 MRPL12 MRPL14 MRPL28 CHCHD1 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 NDUFAB1 MRPL21 MRPL49 MRPL36 MRPS7 MRPS5 MRPL52 MRPL17 MRPL23 MRPL37 MRPL51 MPV17L2 MRPL48 MRPS12 NSUN4 MRPS35 MRPL2 MRPL38 MRPS16 MRPL3 MRPL34 MRPS21 MRPS11 MRPL10 MRPS17 MRPS27 C12orf65 MTG1 MRPL15 MRPL54 up
## GO_ORGANELLE_INNER_MEMBRANE 0.0012920 0.0195512 0.5491069 2.808269 0 461 MRPS34 MRPL55 MRPL24 SLC25A39 ATAD3A SLC25A22 AURKAIP1 ATAD3B MTG2 MRPL4 LETM1 DAP3 ABCB8 MRPL20 AIFM1 IFI6 FOXRED1 MRPS26 NDUFS6 MRPL33 NDUFS8 MRPS2 MRPS15 TMEM177 TM7SF2 PLA2G4A GCAT NDUFV1 NME4 PSEN2 TIMM44 TRAP1 CYC1 CHCHD10 SLC25A10 MRPL12 DNAJC11 MRPL14 MRPL28 FDXR MT-CO2 ERAL1 TIMM50 AGK MT-CYB MFSD10 ACADVL NDUFB10 UQCC2 TMEM120B NDUFB2 NDUFB7 CHCHD1 MRPS33 L2HGDH SLC25A23 LMNB2 MRPS18A SIGMAR1 PMPCA MT-ND4L CBX3 BDH1 FPGS ROMO1 TMEM201 SPG7 MRPS6 SCO2 MT-ND3 MRPL11 SUN1 MT-ND2 TOMM40 MRPL27 NUTF2 NDUFS2 MT-ATP6 MRPL41 MRPL9 SHMT2 NDUFAB1 MT-CO3 MRPL21 ALDH18A1 MRPL49 MT-ND4 MRPL36 NDUFS5 MRPS7 SDHA MRPS5 MRPL52 ACAD9 MT-ATP8 MT-ND5 TIMM13 MRPL17 RSAD2 PISD MT-ND1 BCS1L MT-ND6 CHCHD3 SLC25A45 MRPL23 MRPL37 MRPL51 DPY19L1 SRC HSPD1 NDUFA1 NDUFS3 MPV17 CPOX MPV17L2 MRPS23 PLA2G4B MRPL48 STOML2 MRPS12 COA3 CRAT COA1 MICU1 NDUFV3 COX6B1 MRS2 UQCRQ PHB NDUFA13 MRPS35 NDUFS7 NDUFA11 RPS3 PET100 NDUFB9 ERN1 MTFP1 MRPL2 SLC25A15 SLC25A5 SFXN1 COX4I1 COQ4 COQ9 MRPL38 MRPS16 SLC27A1 MRPL3 TIMM8B ENDOG NDUFAF2 AIFM3 BCL2L1 SPAG4 MRPL34 MCU ECSIT MRPS21 P2RX3 SLC25A29 GRPEL1 COX6C DHODH TIMM9 SLC25A16 CKMT1A MRPS11 BOK GOT2 TIMM10 SDHB NDUFC1 UQCC1 TMEM65 COX7C MRPS25 MRPL10 SFXN4 UQCRH SMAD3 SLC25A11 OXA1L CYP2E1 MT-CO1 PAM16 MRPS17 NDUFAF6 NOA1 NDUFB1 MRPS27 COX5B UQCR10 LEMD2 UQCR11 TIMM17A MTG1 TAZ SLC25A14 CHCHD6 UCP2 NDUFAF3 UCP3 SPHK2 CPS1 THEM4 SLC25A33 MRPL15 UQCRC1 CRLS1 MTCH1 MRPL54 LRPPRC NDUFA4 PTCD3 SLC25A4 C15orf48 IMMT LMNB1 CKMT1B SLC25A51 UQCRC2 NDUFA2 AFG3L2 IFI27 COX8A MCUR1 CLPX MRPL43 TYMS PGS1 SLC25A43 SLC25A13 ABCB10 COX10 MRPS28 HIGD2A NDUFA10 PPIF MRPL44 CPT2 COX5A SDHC ZMPSTE24 up
## GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 0.0015015 0.0195512 0.6408985 2.804475 0 114 SMG5 HELZ2 RNPS1 EIF4G1 DHX34 UPF1 RPL38 RPS2 RPS21 RPL36 PARN RPL37 GSPT1 EXOSC10 UPF3B SMG7 RPL11 RPL8 RPL13 RPLP1 RPL12 RPL35 RPS3 RPL37A RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A PABPC1 RPLP2 RPL27A RPL19 RPS16 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 SMG8 RPS29 RPL3 RPS11 RPS12 RPL14 RPS14 RPL13A RPS10 RPL29 RPL32 PPP2R1A RPS24 RPL26 SMG1 RPS7 RPL35A RPL9 RPS6 RPL23A RPS4X UBA52 SMG9 RPL23 MAGOH RPS15A RPS27A RPS26 RPS8 up
## GO_RNA_BINDING 0.0010893 0.0195512 0.5055213 2.781927 0 1578 TBRG4 TBL3 GPATCH4 CLUH NOP9 CBX4 EIF3B RPUSD1 RNF40 UTP14A FASTK NOC2L UBAP2L PUSL1 NOL3 C1orf35 PRPF6 MYBBP1A SMG5 C7orf50 DDX56 FARSA EEF1D CCDC137 SMARCA4 UBE2I REPIN1 HELZ2 MRPL4 CSTF2 THOC6 DAP3 ZNF598 ADAR APEH MRPL20 METTL1 YTHDF1 DIDO1 TRMT1 PSMD4 MRPS26 PARP1 PABPC1L LONP1 NOL6 EIF3C BMS1 LRRC47 DDX23 MRPS15 P4HB NUDT16L1 LARP1 TUFM ISG20L2 HDGF CBX8 CCDC86 PDIA4 GTPBP2 POLRMT NOC4L CCT6A TRIP6 UBE2O EARS2 EIF2B5 RNPS1 RRP9 DGCR8 FAM50A DDX41 MARK2 AARS2 ATXN2L EBNA1BP2 TRIM56 RRS1 TRMT2A NOP2 STIP1 NOP14 PES1 EXOSC5 EIF6 TRAP1 ENO1 NELFCD PWP2 PPAN SRRM2 PDAP1 RRP1 CCT3 SRPK1 RPUSD2 RP9 MRPL12 LSM4 AKAP1 SETD1A MIR34A ZNF768 NOM1 SNRNP200 MRPL14 DHX37 MRPL28 DDX51 OAS3 EIF4G1 TRUB2 ERAL1 MKRN1 ZNF239 TIMM50 TCF20 LAS1L CTU2 KNOP1 PELP1 PNN SRRT HARS2 SCAF1 ESRP2 LSM14B CCDC124 CDK13 TDRKH GNL3L RANGAP1 UBTF SART1 GRWD1 URB1 RRBP1 MRTO4 SPEN ALYREF KRI1 CHCHD1 DHX34 FDPS NHP2 EDF1 NSUN2 DDX27 LSM7 ZNF74 NCL DDX42 SF3A2 NAT10 SUPT5H POP7 CELF5 EXOSC6 DIS3L2 MRPS18A ZCCHC3 NOP56 TSFM NVL EEF1A2 GNL2 RPS19BP1 RPP25L DUS3L CCT5 DNAJC17 DCPS DDX54 PTBP1 DDX55 TP53 CDK11B IMP4 XPO5 CPSF4 NPM3 MRPS6 TRMU PUS7 PUS1 GTF2F1 AATF UTP3 HNRNPAB SSRP1 RBMX2 IMPDH1 NELFB ARF1 ADK PRMT1 SND1 FLYWCH2 RRP12 MRPL11 MRPL27 SNRPA DNMT1 PKM CHERP KHSRP TARBP1 NOLC1 PPP1R8 KHDC1 ZC3H7B EIF3I MRPL41 RCC2 ALDOA MEX3D MRPL9 CACTIN SF3B2 DDX31 MRPL21 ALDH18A1 BAZ2A NGDN TRA2A EIF3G HTATSF1 DAZAP1 CTU1 RPUSD4 ADAT1 SNRPE EIF2B4 RBM47 PPIA RNASEH1 DDX19A ILF3 HSPB1 MCAT PSMA6 PDCD11 THRAP3 UPF1 SAMD4B UBFD1 RAVER1 FBRSL1 EIF4G3 FTSJ3 NONO NUDT1 TSR1 CPSF6 DIAPH1 MRPS7 TRIM28 HDLBP CARHSP1 ZNF622 MRPS5 PRRC2C DNAJC21 RPL38 THOC3 PPRC1 SLC4A1AP RRP1B EIF3CL MEX3A RPS2 PARK7 CCDC47 APEX1 ENDOV ACIN1 CLK3 RPS21 U2AF2 SUPT6H DROSHA NQO1 EFTUD2 IGHMBP2 MPHOSPH10 KRT18 RPP25 EIF1AD RPL36 LSM5 ELAC2 NKAP RSL1D1 RALY PRKDC PARN CHD2 FXR2 METTL3 ZC3H4 APOBEC3B PA2G4 RPL37 MIR25 GAR1 FKBP4 TARBP2 GSPT1 GTPBP4 EXOSC10 NCOA5 SUPT16H YWHAG DDX19B TPR ILF2 UPF3B COA6 MRPL23 TPD52L2 BST2 TERT SMG7 MAZ HSPA9 SRSF4 WDR6 MIR1207 GTPBP10 SRP68 NIP7 MIR663A RPL11 MRPL37 DNAJC2 POP1 C1QBP SRA1 CCDC9 HSPD1 EXOSC2 LRRC59 MIR135B HSP90AB1 RPL8 ZC3H18 GRB7 TRNAU1AP MCRS1 HNRNPA1 STK31 EDC3 RPL13 IFIT1 ANXA11 MRPS23 HNRNPU MTHFSD SLBP KMT2C FARSB ESRP1 MRPS12 NSUN4 MIR499A WDR33 RPL12 CSNK1E CPSF7 METTL16 SLTM PAIP1 DDX49 NOL12 IARS2 TOP1 RPL35 IMP3 HEATR1 HNRNPUL1 R3HDM2 AKAP8L PABPC3 RBM28 XPOT ZNF579 RNASEH2A PCDHGA9 NDUFV3 TOP3B SHMT1 YTHDF2 EIF5A SNRNP70 RTF1 EIF5B DDX11 DDX46 RBM12B SRRM1 RBM42 DHX38 MRPS35 NME1 EEFSEC RPLP0P6 OAS1 IGF2BP3 CS LSM10 SNRPB RPS3 PRPF39 MRPL2 SNRPC RRP7A GNL3 SLC25A5 DUS2 MOV10 DHX30 EEF2K RBM41 RPL37A POLR2A FBL PNPT1 TUT1 MRPL3 GTPBP1 APTX SETD1B FUS TCERG1 RALYL IMPDH2 KHNYN STXBP1 PABPN1 RPS5 STAU1 RPS15 RPL24 GOLGB1 RPS27 RPLP0 EIF3D SNRPD2 PRRC2B DRG2 RPL27 TRMT6 RPL10A FAM172BP SSBP1 MEPCE CDKN2A PABPC1 TEP1 RPL27A SF3A3 CLNS1A RPL19 RPS16 SCAF4 C1orf131 SNRNP40 PTCD1 RNPC3 SRP54 MRPS21 RRP36 POLR2D DHX8 RPL28 MKI67 RPL39 RPL41 CALR NOSIP YRDC RPL22 TFB2M FASTKD5 GIGYF2 DTD1 FAM120A RPS20 SUGP2 NOP58 SNRNP35 RPL18 GRSF1 CKAP4 MIR3909 MFAP1 MYO18A RPL31 AGO2 RPL18A UBAP2 NKRF RPL30 SERPINH1 CHD3 SLC3A2 DDX28 RPSA ASS1 MRPS11 SLFN13 DHX33 AIMP1 RBM15 GEMIN5 GOT2 FKBP3 PRPF8 RPS28 ZC3H7A FAU DDX39A RPL3 TST PHF5A ANP32A MRPL10 EIF3A MIR429 AHCYL1 EXOSC1 RPS11 EEF2 DDX53 ZC3H12A RPS12 RBM19 NOL9 SNRPF CRKL BYSL THOC2 MIR200B SMAD3 LARP4B DHX9 SLC25A11 RTCB PINX1 ZFP36L1 MIF4GD PABPC4 KTN1 PEG10 RBM33 TCOF1 FASTKD3 DDX12P RPP38 UTP18 SRSF1 ERI3 MRPS17 HUWE1 HNRNPF RPL14 RPS14 NSUN5 NOA1 ELAVL1 RPL13A KPNB1 HNRNPA2B1 MRPS27 BRIX1 C12orf65 ZFR2 EZR FASN ERI1 WDR3 SF3B5 SNRPD3 BOP1 MIRLET7I SF1 UBE2L3 UTP6 TBCA MDM2 NSUN5P1 PRPF4 HNRNPM DHX29 SF3A1 GANAB SUGP1 SLIRP TDRD10 PPIE ZNF346 PUF60 RPS10 PEF1 AKAP8 DCAF13 PCDH20 XRCC6 NUDT5 RPL26L1 NEMF RPL29 TRIM21 NEAT1 PPIB CTNNA1 HABP4 EIF2AK4 RIMS1 RPL32 JAKMIP1 BTF3 CD3EAP OAS2 UCHL5 U2AF1L4 SNRPD1 UBC CELF1 TARDBP EZH2 RPS24 MRPL15 NFX1 DHX57 DIS3L MRPL54 YARS2 C14orf93 BRCA1 CDC5L DHFR RPN1 RPL26 ZNFX1 SPATS2L LRPPRC VCP MIR320A IFIH1 SFSWAP SRSF9 EIF3H MSI1 SUCLG1 PUM1 HSPA8 PTCD3 SAFB MCTS1 DYNC1H1 IMMT SMG1 ESF1 RPS7 SNIP1 USP10 CHTOP PUS3 CSTF1 CCT4 PDIA3 MIR200A LARP1B MIR181A2 RPL35A CCAR2 PARP12 ZC3H11A RPL9 RBM14 WRAP53 A1CF MRPL43 TYMS CAST EIF2B3 RBM23 LLPH POLDIP3 UHMK1 SRPK2 LACTB2 EP300 RPS6 LYAR RAE1 FARS2 THOC5 RPL23A LUC7L RBMX RPS4X HEXIM1 HNRNPA0 MRPS28 IGF2BP1 CPSF1 RPUSD3 CELF4 CBX6 MIR212 CIRBP WDR43 RPL23 SAMD4A MRPL44 CELF3 TSN SNRPG DHX32 EIF4E2 MAGOH RPS15A RNASEL EIF2D ARL6IP4 RPS27A RPS26 RNF20 FUBP3 RPS8 ACTN4 NOP10 PSMC1 SARS2 SON RBM46 ISG20 ZCCHC17 HELB RBM12 UTP15 NOP16 TLR3 HOXB6 HNRNPL NANOS3 DUT SLC16A3 DDX18 CANX OASL ASCC3 TXN HLTF MIR191 SAFB2 MYEF2 SEC23IP DARS2 UTP20 CCAR1 AGO1 TRMT11 NAP1L4 TUBB4B RBM11 MIR210 COIL DSP KHDRBS1 PPP5C SNUPN MTDH PURB GPATCH1 EEF1B2 up
## GO_MITOCHONDRIAL_TRANSLATIONAL_TERMINATION 0.0015924 0.0195512 0.6688027 2.778460 0 86 MRPS34 MRPL55 MRPL24 AURKAIP1 MRPL4 DAP3 MRPL20 MRPS26 MRPL33 MRPS2 MRPS15 MRPL12 MRPL14 MRPL28 ERAL1 GADD45GIP1 CHCHD1 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 MRPL21 MRPL49 MRPL36 MRPS7 MRPS5 MRPL52 MRPL17 MRPL23 MRPL37 MRPL51 MRPS23 MRPL48 MRPS12 MRPS35 MRPL2 MRPL38 MRPS16 MRPL3 MRPL34 MRPS21 MRPS11 MRPS25 MRPL10 OXA1L MRPS17 MRPS27 up
## GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION 0.0014706 0.0195512 0.5975617 2.770187 0 177 EIF3B NOL3 PRPF6 CD2BP2 ADAR MRPL20 EIF3C DDX23 USP39 RRS1 NOP2 EIF6 PWP2 PPAN PRMT5 SRPK1 LSM4 SNRNP200 ERAL1 PRMT7 SART1 MRTO4 GEMIN4 SF3A2 CELF5 RUVBL1 NLE1 PIH1D1 PRPF19 TXNL4A RUVBL2 XAB2 MRPL11 EIF3I EIF3G SNRPE CPSF6 MRPS7 RPL38 EIF3CL TARBP2 RPL11 HSP90AB1 RPL12 CPSF7 RPLP0P6 SNRPB PRPF39 SNRPC RRP7A DHX30 AAR2 GEMIN2 RPS5 RPS15 RPL24 RPS27 RPLP0 EIF3D SNRPD2 SF3A3 CLNS1A POLR2D DHX8 AGO2 DDX28 RPSA MRPS11 GEMIN5 PRPF8 RPS28 RPL3 EIF3A MDN1 SNRPF DHX9 TFIP11 SRSF1 RPS14 RPL13A BRIX1 SNRPD3 BOP1 SF1 SF3A1 RPS10 GEMIN6 SNRPD1 CELF1 ZNHIT6 TGS1 VCP SFSWAP SRSF9 EIF3H PRPF18 MCTS1 ZFAND1 SRPK2 ATR RPL23A LUC7L RBMX CELF4 CELF3 SNRPG EIF2D GEMIN7 up
## GO_MITOCHONDRIAL_MATRIX 0.0013158 0.0195512 0.5444496 2.760222 0 424 TBRG4 FLAD1 DNAJA3 MRPS34 COASY MRPL55 MRPL24 FASTK TOP1MT PYCR2 ATAD3A MTG2 MRPL4 TARS2 DAP3 ACAD8 MRPL20 ECI1 MRPS26 MECR LONP1 MRPL33 NDUFS8 MRPS2 PC MRPS15 MPG TUFM GCDH PYCR1 POLRMT NME4 EARS2 TIMM44 TRAP1 MALSU1 HAGH MRPL12 PDP1 MRPL14 MRPL28 FDXR TRUB2 ERAL1 GADD45GIP1 D2HGDH HARS2 ACADVL ECHS1 UQCC2 ATG4D CHCHD1 SUOX MRPS33 MRPS18A PMPCA TSFM BDH1 FPGS TP53 ETFB MRPS6 ADPRHL2 BCAT2 PUS1 ACP6 PCCB SCO2 MRPL11 MRPL27 FAHD1 NDUFS2 GPT2 MRPL41 DTYMK MRPL9 SHMT2 NDUFAB1 MRPL21 MCCC2 MRPL49 RPUSD4 MCAT MRPL36 NUDT1 MRPS7 MRPS5 MRPL52 PARK7 MRPL17 PRDX5 NARS2 ELAC2 ACSS2 IDH3B BCKDK CHPF MARS2 SIRT3 MRPL23 TERT DHTKD1 HSPA9 NAGS ACSF3 MRPL37 MRPL51 C1QBP HSPD1 NDUFS3 LRRC59 PCK2 GSTK1 MPV17L2 MRPL48 MRPS12 NSUN4 IARS2 OGDH PDHA1 MPST MRPS35 PDP2 NDUFS7 CS RPS3 IDH2 MRPL2 HIBADH SLC25A5 DHX30 GLS2 MRPL38 MRPS16 MRPL3 ACO2 BCL2L1 THEM5 GLS SDHAF1 SSBP1 SHC1 TXN2 GCSH ETFA OAT ACSF2 PITRM1 ACADSB DGUOK MRPL34 ALKBH7 PTCD1 MRPS21 NAT8L TFB2M FASTKD5 IVD GRPEL1 GRSF1 ARG2 DDX28 TRIT1 MRPS11 GOT2 PARS2 TXNRD2 NFS1 TST LIPT2 MRPL10 GLDC CCNB1 OXA1L CLPP HADH PAM16 OXCT2 MRPS17 MRPS27 C12orf65 MLYCD NT5M ABAT ALDH5A1 MTG1 POLG FH ALDH4A1 CPS1 THEM4 MRPL15 HMGCL MRPL54 YARS2 ALDH1B1 LRPPRC SDHAF2 FXN ACADS ME3 TRMT5 SUCLG1 LARS2 PDSS2 MCCC1 UQCRC2 CCAR2 CLPX MRPL43 TYMS LACTB2 FARS2 PHYKPL MRPS28 TRMT61B RPUSD3 GSR NDUFA10 PPIF MRPL44 up
## GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 0.0016420 0.0195512 0.7048526 2.754748 0 62 NOC2L MRPL20 EBNA1BP2 RRS1 NOP2 PES1 EIF6 MALSU1 PPAN LAS1L URB1 MRTO4 NHP2 NLE1 NVL MRPL11 FTSJ3 ZNF622 RPL38 RSL1D1 GTPBP4 PAK1IP1 NIP7 RPL11 RPL12 RPL35 RPLP0P6 DHX30 RPL24 RPLP0 RPL10A WDR74 DDX28 RPL3 MDN1 NOL9 RPL14 BRIX1 BOP1 RPL26L1 ZNHIT6 RPL26 RPL35A HEATR3 WDR12 RPL23A up
## GO_MRNA_METABOLIC_PROCESS 0.0011976 0.0195512 0.5184752 2.753017 0 763 TBRG4 SSU72 SNRNP25 RNF40 NOL3 PRPF6 SMG5 PLEKHN1 AURKAIP1 EDC4 CD2BP2 HELZ2 CSTF2 THOC6 PKP3 ADAR POLR2J PSMD4 PABPC1L IWS1 PSME2 DDX23 USP39 LARP1 GTPBP2 RNPS1 DDX41 ZC3H3 TSEN54 PRCC EXOSC5 PRMT5 SRRM2 SRPK1 LSM4 MTOR SNRNP200 EIF4G1 TRUB2 POLR2L TNKS1BP1 POLR2H SCNM1 PNN PRMT7 SRRT SCAF1 ESRP2 CDK13 SART1 PSMD3 MRTO4 ALYREF DHX34 TRMT61A GEMIN4 LSM7 NCL DDX42 SF3A2 SUPT5H CELF5 EXOSC6 DIS3L2 PSMC4 DCPS PTBP1 TP53 CDK11B E2F1 CPSF4 PUS7 PRPF19 PUS1 GTF2F1 CMTR1 RBMX2 TXNL4A XAB2 SNRPA CHERP KHSRP ERCC2 PPP1R8 MEX3D CACTIN SF3B2 AKT1 BRDT CNOT11 TIRAP TRA2A HTATSF1 DAZAP1 SNRPE PSMC3 SF3B3 PHRF1 HSPB1 PSMA6 PDCD11 POLR2E THRAP3 UPF1 SAMD4B NONO CPSF6 PSMB5 PSMA5 PSMD2 CARHSP1 RPL38 THOC3 RRP1B RPS2 APEX1 ACIN1 RPS21 ZMAT2 U2AF2 SUPT6H CDK12 EFTUD2 RPL36 LSM5 RALY PARN FXR2 METTL3 PSMB4 RPL37 DDIT3 PRKCA SREBF1 GSPT1 EXOSC10 MNAT1 UPF3B SMG7 SRSF4 RPL11 CWC25 C1QBP PSMA7 PSMC6 EXOSC2 RPL8 PSME3 HNRNPA1 POLR2F EDC3 RPL13 RPLP1 ZNF830 HNRNPU RNF113A SLBP RPRD2 WDR83 PSMB2 ESRP1 PSMC5 WDR33 RPL12 SYMPK CPSF7 PSMB10 METTL16 SLTM PAIP1 RPL35 HNRNPUL1 PSMB6 AKAP8L PABPC3 RBM28 YTHDF2 CLASRP SNRNP70 DDX46 SRRM1 RBM42 DHX38 PAF1 IGF2BP3 LSM10 SNRPB RPS3 PRPF39 ERN1 SNRPC PSMD13 PSMB3 MOV10 AAR2 RPL37A PSMD11 POLR2A PNPT1 TUT1 GTPBP1 FUS GEMIN2 CDK11A PABPN1 RPS5 RPS15 RPL24 RPS27 RPLP0 SNRPD2 RPL27 TRMT6 RPL10A RNH1 FOXE3 PABPC1 PPARD RPLP2 RPL27A SF3A3 CLNS1A PSMC2 RPL19 RPS16 ERCC3 SNRNP40 RPRD1B RNPC3 POLR2D DHX8 PSMF1 RPL28 RPL39 RPL41 RPL22 FASTKD5 GIGYF2 RPS20 SUGP2 SNRNP35 RPL18 GRSF1 MFAP1 RPL31 AGO2 RPL18A RPL30 ZMAT5 BUD31 RPSA RBM15 GEMIN5 PRPF8 RPS28 SMG8 RPS29 DDX39A RPL3 PAN2 PPIH PHF5A ANP32A AHCYL1 EXOSC1 RPS11 ZC3H12A RPS12 RBM19 SNRPF THOC2 CCNB1 DHX9 PELO ZFP36L1 PABPC4 FASTKD3 TFIP11 SRSF1 HNRNPF PSME1 RPL14 RPS14 ELAVL1 RPL13A HNRNPA2B1 PCIF1 SF3B5 SNRPD3 SF1 PRPF4 POLR2I HNRNPM SF3A1 SUGP1 PPIE PUF60 PPIL1 RPS10 ZBTB7A RPL29 PRDX6 HABP4 LEO1 NUP214 RPL32 GEMIN6 U2AF1L4 SNRPD1 UBC TTF2 CELF1 TARDBP PPP2R1A RPS24 TGS1 CDC5L RPL26 SFSWAP SRSF9 PRPF18 PUM1 HSPA8 SAFB SMG1 PSMD8 RPS7 SNIP1 CHTOP PUS3 CSTF1 RPL35A CCAR2 ZHX2 ZC3H11A RPL9 A1CF RBM23 POLDIP3 SRPK2 RPS6 THOC5 RPL23A LUC7L RBMX RPS4X PDCD7 PQBP1 HNRNPA0 TRMT61B IGF2BP1 CPSF1 RPUSD3 CELF4 UBA52 SMG9 CIRBP RPL23 SAMD4A CNOT2 PSMA3 CELF3 SNRPG MAGOH POLR2C RPS15A RNASEL PSMD9 ARL6IP4 RPS27A RPS26 GEMIN7 EREG RNF20 RPS8 TSEN15 TFCP2 PSMC1 IK SON RBM46 UBL5 up
## GO_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0015432 0.0195512 0.6471097 2.741731 0 94 RPL38 RPS2 RPS21 RPL36 RPL37 SRP68 RPL11 RPL8 RPL13 RPLP1 RPL12 RPL35 RPS3 SSR2 RPL37A RPS5 SEC61A1 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 SRP54 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 ZFAND2B RPL31 RPL18A RPL30 RPSA RPS28 RPS29 RPL3 RPS11 RPS12 RPL14 RPS14 RPL13A RPS10 RPL29 RPL32 RPS24 RPL26 RPS7 RPL35A RPL9 RPS6 RPL23A RPS4X UBA52 RPL23 RPS15A RPS27A RPS26 RPS8 TRAM1 up
## GO_MITOCHONDRIAL_ENVELOPE 0.0012092 0.0195512 0.5206226 2.736255 0 643 MRPS34 COASY MRPL55 MRPL24 SLC25A39 ATAD3A PLEKHN1 SLC25A22 AURKAIP1 ATAD3B CAPN2 MTG2 MRPL4 LETM1 DAP3 ABCB8 MRPL20 AIFM1 QTRT1 MTX1 AK2 IFI6 FOXRED1 MRPS26 NDUFS6 MRPL33 NDUFS8 MRPS2 MRPS15 TMEM177 RHOT2 PLA2G4A GFER GCAT NDUFV1 NME4 PSEN2 COA4 TIMM44 AIFM2 TRAP1 CYC1 MAVS CHCHD10 GOLPH3 BECN1 SLC25A10 MRPL12 AKAP1 DNAJC11 MTOR MRPL14 MFN2 MRPL28 FDXR HKDC1 THOP1 CYP27B1 MT-CO2 HAX1 ERAL1 TIMM50 AGK MT-CYB ACADVL ANKZF1 NDUFB10 UQCC2 NDUFB2 NDUFB7 CHCHD1 SUOX MRPS33 L2HGDH PI4KB CHCHD2 SLC25A23 MRPS18A PMPCA BAD MT-ND4L BDH1 FPGS CPT1B ROMO1 SPG7 MRPS6 FLVCR1 SCO2 MT-ND3 MRPL11 MT-ND2 TOMM40 MRPL27 NDUFS2 MT-ATP6 MRPL41 DTYMK MRPL9 SHMT2 COX19 NDUFAB1 MT-CO3 MRPL21 ALDH18A1 MRPL49 FIS1 MT-ND4 BPHL MRPL36 NDUFS5 MRPS7 SDHA MRPS5 MRPL52 ACAD9 CHCHD5 PARK7 MT-ATP8 MT-ND5 TIMM13 MRPL17 RSAD2 PISD MT-ND1 BCS1L MT-ND6 AMBRA1 BNIP1 CHCHD3 SLC25A45 PGAM5 PRKCA GPER1 COA6 MRPL23 BAK1 MRPL37 MRPL51 SRC BAX HSPD1 TOMM40L NDUFA1 NDUFS3 MGST1 MPV17 BRI3BP CPOX MPV17L2 MRPS23 PLA2G4B MRPL48 STOML2 MRPS12 COA3 HK1 OGDH CRAT COA1 MICU1 NDUFV3 COX6B1 MRS2 UQCRQ MARC1 PHB NDUFA13 MRPS35 NME1 TOMM34 NDUFS7 NDUFA11 RPS3 PET100 NDUFB9 MTFP1 MRPL2 SLC25A15 SLC25A5 SFXN1 COX4I1 COQ4 COQ9 MRPL38 GPAT2 CHCHD4 PNPT1 MRPS16 SLC27A1 GRAMD4 MRPL3 PMAIP1 TIMM8B ENDOG BNIP3 CYB5B NDUFAF2 NLN AIFM3 BCL2L1 MSTO1 TOMM22 MUL1 MRPL34 NLRX1 UBIAD1 MCU ECSIT MRPS21 TOMM7 NAT8L SLC25A29 COX17 IVD GRPEL1 COX6C ACSL5 DHODH TIMM9 ASS1 SLC25A16 CKMT1A MRPS11 CIAPIN1 BOK GOT2 TIMM10 SDHB RAB11FIP5 NDUFC1 UQCC1 TMEM65 SFXN2 TRIM14 COX7C MRPS25 MRPL10 SFXN4 UQCRH PRELID1 ULK1 FKBP8 GNPAT SLC25A11 OXA1L CYP2E1 MT-CO1 MLXIP PAM16 MRPS17 COX14 SORD NDUFAF6 NOA1 NDUFB1 TOMM20 MRPS27 COX5B UQCR10 RMDN3 IFI27L2 MTX2 IKBKE UQCR11 TIMM17A MTG1 TAZ ABCB6 SLC25A14 CHCHD6 UCP2 NDUFAF3 UCP3 SPHK2 CPS1 THEM4 UBC SLC25A33 MRPL15 UQCRC1 CRLS1 MTCH1 MRPL54 NDUFA4 PTCD3 SLC25A4 C15orf48 IMMT CKMT1B SLC25A51 UQCRC2 NDUFA2 MYO19 AFG3L2 IFI27 COX8A MCUR1 CLPX MRPL43 BCL2L13 TYMS MAPK8IP1 PGS1 SLC25A43 SLC25A13 ABCB10 COX10 LETMD1 MRPS28 HIGD2A CASP8 UBA52 NDUFA10 PPIF MRPL44 CPT2 COX5A SFXN5 SDHC CYB5A VDAC1 RPS27A BCL2L10 PRODH OGT SLC25A35 PANK2 up
fgsea_plot(fgsea_res$res_c6, pathways_title='C6 oncogenic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------------------ ---------- ---------- ---------- --------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## MYC_UP.V1_UP 0.0014728 0.0084906 0.6229292 2.838017 0 157 HS6ST2 UTP14A TOP1MT SLC25A22 FAM86C1 PRR7 REPIN1 WDR4 QTRT1 METTL1 TRMT1 NR2C2AP NOL6 ALG3 SMYD5 PLA2G4A NOC4L C19orf48 RRP9 ECE2 DGKD RPTOR NOP14 PES1 EXOSC5 CHCHD10 MNT VPS9D1 QSOX2 DGAT2 LAS1L IPO4 CCDC124 MRTO4 LRRC61 TSFM NLE1 B3GNTL1 ISOC2 TMEM201 PUS7 CDCA7L PUS1 RRP12 KLF16 C12orf66 SPATC1L PMM2 RPUSD4 CD320 PPRC1 DCTPP1 MPHOSPH10 DPP7 NIP7 TRNAU1AP FARSB WDR83 AGPAT3 MICU1 MTFP1 SLC25A15 GLS2 MON1A ABCC6P2 USE1 ICAM5 SAC3D1 UBIAD1 SCFD2 TFB2M SLC29A4 GEMIN5 AMPD2 AHSA1 DLL3 JPH1 TSSC4 SIX3 TGFBRAP1 C5orf46 GPD1L SORD C20orf27 TDRD10 NEFH CHKA CD3EAP RRP15 DIS3L KLRG2 ESF1 PUS3 up
## CAMP_UP.V1_UP 0.0014327 0.0084906 0.5641069 2.617706 0 181 WDR24 PYCR2 RBCK1 DAP3 SIL1 LONP1 SMYD5 DDX23 P4HB RHOT2 NDUFV1 EARS2 TFPI2 SRPK1 GMPPA HAX1 IPO4 CCDC124 RABGGTA TRMT61A CEP250 SESN2 RUVBL1 MRPS18A HSPA5 CHAF1A MAEA TRIM2 TMED9 TMEM9 AATF CMTR1 ARF1 PRMT1 NDUFS2 ALDOA MIDN FAHD2A GAS5 HDLBP AAAS PA2G4 TYMP ILF2 DPM2 HSPA9 NRSN2 TOMM40L SAT2 HSPBP1 HNRNPU POLR3H CNDP2 CLPTM1 NME1 CS SLC25A5 PLCH1 TMEM8B PMAIP1 ACO2 UPP1 NUAK2 SEC61A1 COPE WASH3P FBXO42 ECSIT KANSL3 RPL18A CKMT1A GPR160 SLC35A4 AHCYL1 TRIM38 SLC25A11 OXA1L SEC13 DPAGT1 CYBA PPIB ZNF367 METTL17 MRPL15 URM1 NFX1 RPN1 KAT5 PDIA3 COX8A CRABP1 EIF2B3 RNF41 SELENBP1 COPZ1 LETMD1 LRR1 TNIK MAGOH NQO2 ATF4 IFITM1 ATP1A1 SLC22A17 IFIT2 SDAD1 IFITM3 HSP90B1 TAF1D up
## PRC2_EED_UP.V1_DN 0.0014327 0.0084906 0.5161162 2.391680 0 179 ABCB9 TBL3 SLC26A1 LRRC20 PACSIN3 PHKG2 ABCB8 QTRT1 RECQL4 PC AP1G2 CDK18 BTBD2 TRMT2A TMEM59L PWP2 CLPB TSC2 MFHAS1 PRMT7 PAGR1 ANKZF1 RANGAP1 DNAJB2 GSDMD ATP13A2 SLC35C2 STXBP2 POLD1 ERCC2 WIZ DDX31 CHAF1B MYBL2 THRAP3 ASF1B TACC3 CAD AMDHD2 MICALL2 APLP1 BCKDK MCM2 CDCA8 PLK1 EXOSC2 MVD INCENP CLSPN SYMPK LIPE TNK2 ACY1 VAC14 GLE1 TOP3B IDH2 GALK1 TAF1C TUT1 TCIRG1 TRPM4 MCM10 TRIM46 KIF4A SURF2 JUP ODF2 DBF4B RAD54L ORC1 FZD8 NUP188 ALG12 TUBGCP2 RNF19A FASN BBC3 FRS2 MAP3K6 PLXNB1 USP20 PACS1 BUB1B ZNF446 up
## RPS14_DN.V1_DN 0.0014347 0.0084906 0.5103186 2.355741 0 172 TBRG4 GPATCH4 LRRC20 ELMO3 MACROD1 MRPS2 PC SPTB EPCAM GCDH PYCR1 THEM6 SRM SLC29A2 AGAP1 RRS1 TK1 TUBG1 PES1 RPUSD2 MRPL12 IPO4 MRTO4 EPB41 GEMIN4 ZNF74 ZNHIT2 NLE1 PSAT1 ISOC2 POLD1 ASNS SRD5A3 ERCC2 LGR4 ATAD2 MYBL2 CD320 CAD CBS STEAP3 PLK1 AGFG2 DDN INCENP ALAD TUBB2A SHMT1 TUBB2B MCM10 MKI67 KIF20A BAG3 RPS28 DGCR11 CDC20 ORC1 KIF2C BYSL NMU TWISTNB KLHL7 TUBGCP4 CDC6 CDR2 CHAC1 NEFH ESPL1 EXO1 FZD5 LARS2 MYO19 RAP1GAP COLEC11 EIF2B3 LLPH MCM5 up
## CSR_LATE_UP.V1_UP 0.0014837 0.0084906 0.4759339 2.162688 0 156 EIF3B NOC2L POLR3K FARSA CDK5 NUDC SRM C19orf48 TUBG1 PRMT5 FEN1 KIF22 UBE2C TUBA4A ASB6 UMPS LMNB2 YIPF3 MET IMP4 POLD1 DTYMK GYS1 CHEK2 NKX2-1 MYBL2 PSMC3 PSMD2 DCTPP1 KRT18 PA2G4 ILF2 CDCA8 MAZ CTPS1 PREB ZWINT PAICS DRAP1 FARSB CASP2 CLSPN UHRF1 EIF5A TOMM34 BIRC5 FOXM1 PDCL3 RRM2 FANCA ALKBH7 CIAPIN1 SLC16A5 CCDC34 YEATS4 AHSA1 SLC25A11 MCM3 ANLN UTP18 CDC6 DNAJB11 up
## RB_P130_DN.V1_UP 0.0015129 0.0084906 0.4799518 2.096614 0 114 POLD2 QTRT1 GFER OXLD1 FAM220A TK1 LSM4 CRB3 SDF2L1 KIF22 UBE2C RGL3 TRAF2 TRAF4 ELOF1 RUVBL2 CRLF1 DCTPP1 EFTUD2 ICA1 EXOSC2 NSMCE1 ZBTB17 GRTP1 NKX2-8 BIRC5 SNRPB ENKD1 SGSM3 C12orf10 CUEDC2 SIM2 RIPK3 KIF20A PARS2 ORC1 RASD1 AURKA MBD3 ATP2A1 RAD51D SNTA1 ZNF428 HINT1 AURKB POLR2I USP13 CYBA CHCHD6 up
## EIF4E_UP 0.0015723 0.0084906 0.4925028 2.056098 0 88 SNRNP25 C16orf91 METTL1 PFDN2 TUFM VPS72 FN3KRP PAGR1 CACNB3 CHCHD1 RSAD1 ISOC2 SNX8 NPM3 PMM2 CAMK2N2 UBFD1 MRPL17 DNPH1 SNTB1 ANKRD16 FOXD2 JOSD1 NKX2-8 TALDO1 MRPS35 MON1A TP53I11 PPCS TST AHSA1 C8orf33 MTX2 GEMIN6 VPS28 UROS MAPK8IP1 UBL4A PHYKPL MAP2K3 FAM117A NOP16 DEDD TMEM11 IDH1 ATP8B3 SRXN1 C6orf226 EIF4A3 NTPCR up
## PDGF_ERK_DN.V1_DN 0.0014728 0.0084906 0.4423069 1.990296 0 141 FADD GIPC1 FBXL18 ZNF500 IDUA ARHGEF16 PRCC MOGS ISL1 CDK2AP2 MNT PITPNM1 DTX2 DHX34 SUOX NCAPH2 DUSP8 SNAPC4 EFNA3 FAM50B CCNF SCO2 PPP6R1 PRSS16 TBCC PPRC1 PISD KDM2A MAD2L1BP ZNF202 CIC ARF6 FAM89B BRPF1 PDE4A SAC3D1 CDR2L MFSD5 PHLPP1 TRAIP SLC3A2 THAP11 TBKBP1 MBD3 ZSCAN9 MON1B FBXL14 TFIP11 C2CD2L APC2 PPP2R5B NEFH ZNF324 ERF BPGM TRIB1 TMEM115 BCL9 CEBPB PPM1A NOP16 CKS2 HIC2 HINFP TMEM11 FAM102A ZBTB5 RTN2 NFKBIA KLHL25 MAPK3 E2F6 SULT1A1 FRAT2 DYRK2 up
## RB_P107_DN.V1_UP 0.0015198 0.0084906 0.4495703 1.982147 0 128 SAMD10 LGALS3BP WDR90 RPL39L NAA40 ANAPC11 TUBG1 FEN1 PAQR4 E2F1 CCNF TCFL5 IPO9 POLD1 TMEM45B CHAF1B PRDX4 POLE ASF1B MCM7 NXT1 MCM2 INCENP SPIRE2 SLBP BLVRB RRM2 KIF4A FANCA LYPD1 LIG1 CDC25B BEX2 PML RPA3 TSSC4 HAUS8 SIVA1 PTMA WDHD1 ABAT DCLRE1A GINS4 VEGFB NCAPD2 DHFR PCNA MCM5 SRPX2 GMNN HMCES RPA1 POLE2 NCAPH CCNE1 FKBP10 CCNE2 ORC6 CDC45 PRC1 DNA2 GTSE1 CENPH SYCE2 up
## E2F1_UP.V1_UP 0.0014286 0.0084906 0.4212737 1.946954 0 173 TAF6 UBN1 CSTF2 PARP1 USP39 MPG UBE2T TK1 EIF6 FEN1 THOP1 PITPNM1 GRWD1 GPN2 SLC35E1 NOP56 ERCC2 NOLC1 CHAF1B PHF12 DNAJC21 RRP1B MCM4 DCTPP1 PTPRU CAD SRSF4 DNAJC2 PSME3 HSPBP1 BOLA3 SLBP VEGFA MAP3K11 DDX46 ARHGAP8 CLN6 VPS37B MCM10 INO80E CDR2L GRSF1 AGO2 LPIN2 RBM15 BOK RND2 STIL UQCC1 SHBG CNIH2 LARP4B ARHGAP39 AURKB ELAVL1 BUB1 WDHD1 CYBA ZFPM1 PACS1 SLC9A3R1 SLC7A1 ADCY6 EZH2 DDB1 POLA2 PIGA LMNB1 USP10 TYMS MED20 PARP16 UPK2 CHEK1 NASP DLGAP5 E2F3 TYRO3 NCAPH MRPL46 ZSWIM7 PRADC1 TOP2A FANCM PRC1 DBF4 DNA2 up
## RB_DN.V1_UP 0.0015408 0.0084906 0.4403919 1.933223 0 123 MAPK13 PMS2 NME4 UBE2T TUBG1 TIMELESS TMEM54 PDXP AHCY STUB1 DCXR MAN1B1 DNMT1 TTI1 SLC35B2 MRPL49 SLC2A8 TNFRSF18 MCM7 AAAS NXT1 PLXNB2 OVOL2 GRB7 SLBP VPS16 CLN6 RRM2 POLD4 SPICE1 LCMT1 TIPIN CCDC88C TNFSF9 DSN1 ZSCAN22 RAD54L EI24 GNB1L SIVA1 CTC1 BBC3 PRKAB1 MDM2 C20orf27 NUDT5 PMM1 PLEKHA6 UCK1 IL36RN PCNA up
## E2F3_UP.V1_DN 0.0014948 0.0084906 0.4327642 1.932307 0 137 TBRG4 MRPL55 AXIN1 FBXL19 PVT1 NAT9 PC ZNF646 SPTB CDH15 KRT80 MARK2 SNHG3 PPAN PLAT NT5C ZNF3 STK40 URB1 RAB43 SPRR1B ADM2 SNAPC4 CBX3 CBLC LRRC8E POLR1A RNF215 EIF3CL LIF NR6A1 POP1 PRSS33 RUSC1-AS1 PMAIP1 SNORA28 EHMT1 WASH3P PPARD INTS7 GPRC5A SOX1 HOXC4 BYSL MEGF6 ZFAS1 B3GNT3 FBXO27 ADAM8 BDKRB2 ANKRD46 ETV3 NRL ESF1 up
## ESC_J1_UP_LATE.V1_DN 0.0014184 0.0084906 0.4141298 1.919020 0 174 HOOK2 GPATCH4 POLR3K TSPAN17 MTG2 BMS1 PHLDA2 RRP9 KNOP1 HARS2 TCEA3 DDX27 AMH ETV4 LMNB2 PIH1D1 SFN PASK CRCP PUS7 RRP12 ARMC6 GYS1 ANGPTL4 POLE TBCE RPP25 SLC4A3 WWP2 ATG2A WDR83 NSUN4 ZFP62 DDX49 PHB BCL3 TUBB2B SLC1A5 ENDOG GEMIN2 TRH CLTB RNPC3 ECH1 TRAIP PPCS NAPSA DHODH GNG3 MSANTD2 EXOSC1 MDN1 ICAM1 PPP4R1 ZNF428 PRMT6 MVK NEFH MSRB2 SULT4A1 up
## AKT_UP_MTOR_DN.V1_UP 0.0014472 0.0084906 0.4170189 1.914081 0 166 PACSIN3 GIPC1 MVP PFDN2 GUSB DHCR7 SNHG11 TPRN PLAT PDZD11 LRG1 SUSD4 ING2 TNFRSF12A DUSP8 FBXO6 DAGLB MLLT1 ZNF746 CD55 TMEM186 ABCA7 CRLF1 ADORA2B FXR2 MAN2B2 PARM1 TOR3A GGA1 RAB3IP TJP3 PON1 KCNK5 GSDMC IFIT1 MAL2 NOL12 FBXL15 MICU1 SUCO PON2 RUNDC3A TACSTD2 SGPL1 LYPD1 MYO5B PAK1 ALDOC RASD1 GLDC FKBP8 GAK GDE1 CTNS RNF19B up
## SIRNA_EIF4GI_UP 0.0015625 0.0084906 0.4549563 1.895047 0 87 GSS ECI1 NDUFS8 EMC9 CORO1B SPRR1B FBXO46 DDX54 SETDB1 MAGEF1 HSPB1 NONO NQO1 HSPD1 LRPAP1 MPV17 CPNE1 PDHA1 SLC25A5 S100A14 TCF25 ASS1 TNNT1 PSME1 DAG1 NCAPD2 CEBPD UQCRC2 CCT4 AFG3L2 LETMD1 DRG1 ADSL ATP1A1 PERP EIF3K PTPN13 SPRR1A CTSH PYGL ALDH7A1 MIA3 PMPCB up
## RAPA_EARLY_UP.V1_DN 0.0014430 0.0084906 0.4088171 1.877455 0 167 CBX4 HLCS ESRRA LGALS3BP TAF4 MARK2 STK11 OSBPL2 YIPF2 COL9A2 NUMA1 BRMS1 ZNF3 SPRR1B SF3A2 OVOL1 ABTB2 GPT SNAPC4 MET BCAT2 SEC16A SCO2 CIT CHKB DPH1 PISD BCKDK SNTB1 PSMA7 EPHB4 DDN ATG2A XRCC1 ACY1 MICU1 PSMD13 WDTC1 RNF167 INPP5J GDPD5 APBA3 LMNA GALNS NAGPA WNK1 GBF1 TFAP2A GRIN1 ACTR1B LHB SNTA1 EIF4EBP1 KDM4B PCSK2 TROAP BBC3 ITPKC NFE2L1 SLC9A3R1 SYNGR4 ALDH1B1 CRY2 KDM4A IFI27 PSD KISS1 CIB2 PDZK1IP1 up
## CYCLIN_D1_KE_.V1_UP 0.0014286 0.0084906 0.4009048 1.858670 0 178 COASY HSF4 PHKG2 AXIN1 E2F4 CTBP1 DNASE1 SLC6A3 MAD1L1 NTN3 DGKD FOXK2 THOP1 TSC2 KIF22 TTLL12 SUPT5H PMPCA RASSF7 GPT ZIC1 POLD1 ASNS DAP LMF2 CENPB PFKL PTPN3 PCGF2 ZNF787 LTBR BATF MMP15 EIF5A LCN2 SNRPC KCTD2 CDKN2A CDR2L MED24 EPHA2 COX17 MAN2A2 LPIN2 TFAP2A SCAP TRIO BRF1 CYP2E1 TROAP CHRNA5 STT3A MALL CDR2 PPIB CHKA PKN1 FZD5 FHL2 RUNX1 EVX1 CEBPD CCL20 KAT5 GOT1 BCL9 PTPRH PLOD1 CHRNB4 HOXC5 ALDH3A2 ADRA2A POLR2C DMWD GGT5 IFITM1 CDS1 PPP5C FAM3C PKD1 S100A2 AHR up
## AKT_UP.V1_UP 0.0014771 0.0084906 0.4075234 1.847052 0 152 PACSIN3 GIPC1 COMTD1 GUSB DHCR7 SNHG11 TPRN PLAT PDZD11 LRG1 UBE2C TNFRSF12A TRAF4 FBXO6 CD55 SECTM1 ABCA7 CRLF1 ADORA2B FXR2 MAN2B2 PARM1 TOR3A TOM1L1 TJP3 KCNK5 GSDMC IFIT1 MAL2 MMP15 MICU1 SUCO SGSM3 PON2 CYP51A1 RUNDC3A TACSTD2 SGPL1 S100A14 RIPK3 MYO5B PAK1 ALDOC GAK GDE1 RHOV PFKP IFIT3 FDFT1 BPGM SYT17 DHCR24 GOT1 CALCB DUSP10 MPZL2 HOXB9 LGMN HIC2 IFIT2 CAMKK1 GPD2 SAA4 SPRR1A up
## MTOR_UP.N4.V1_UP 0.0014265 0.0084906 0.3911658 1.820188 0 183 TBRG4 RPAP1 ASPHD1 COASY BSPRY TRIB3 DHCR7 CCDC86 PYCR1 GALE RRP9 TIMM44 EBNA1BP2 CLPB PSPH SDF2L1 CDK16 ISOC2 RRP12 ASNS SLC7A5 E2F5 SLC4A1AP ACACA DDIT3 SREBF1 GFPT1 PAK1IP1 RIMS3 PCK2 DDN TUBB2A SPRED2 VEGFA BATF RBM28 FAH SLC1A5 BNIP3 GPRC5C STX4 YRDC SLC39A4 ARG2 SLC3A2 ASS1 CNIH4 EIF4EBP1 LHX2 KLHL7 DNMT3B CHAC1 RRP15 PLS1 KIF21B LARS2 SLC6A9 PDXK PJA1 RABEPK VPS33B PHGDH GOT1 EIF2B3 SAR1B ELOVL6 COX10 CEBPB ULBP1 CASR NUP155 NQO2 DBN1 DLEU1 LGMN OPRL1 FKBP11 IDH1 NME7 DDIT4 MAST2 USH1C up
## ESC_J1_UP_EARLY.V1_DN 0.0014728 0.0084906 0.3986123 1.808719 0 153 GPATCH4 B3GALT6 MTG2 REEP6 BMS1 TRIB3 SYT12 GID8 BLOC1S4 C19orf48 MAD1L1 AP4M1 TNFRSF12A AMH RAMP1 RPS6KB2 TMC6 ETV4 SFN RRP12 CENPB ANGPTL4 GNA14 RPP25 ARHGEF10L NAB2 NINJ2 NSUN4 CORO2A NOL12 SAP30BP PHB BCL3 C11orf24 ARHGAP35 TRAIP PPCS NAPSA MRPS11 DRD4 PPP2R3A MDN1 ZFP36L1 FAM118B KTI12 MVK ERF CEBPD ZBP1 PAFAH2 VPS33B WSB1 LLPH REM2 up
## MTOR_UP.V1_UP 0.0014728 0.0084906 0.3960451 1.797070 0 153 TARS2 GSS USP18 COMTD1 SCGB3A2 DHCR7 CCDC86 CAPN12 PPAN PLAT UBE2C PCYT2 FDPS TNFRSF12A BDH1 PSAT1 IFI35 TMEM53 SC5D ADORA2B PRKCA ABCA2 BST2 KRBA1 HTT RCOR2 GSDMC IFIT1 UHRF1 IL27RA NTSR1 ERN1 COQ4 RRM2 CYP51A1 S100A14 MSX2 TIPIN FAM131A CDC20 ALDOC H6PD PFKP OAS2 FDFT1 TRMT5 PCNA PAFAH2 DHCR24 CCAR2 MCM5 LTV1 SLC41A3 SERPINB5 NQO2 AP2B1 HIVEP3 PRAF2 FGFBP1 IFIT2 NEIL3 RANBP9 SPRR1A DBF4 PYGL LSS up
## ESC_V6.5_UP_LATE.V1_DN 0.0014472 0.0084906 0.3881771 1.778068 0 165 GPATCH4 MTG2 GGCT TRIB3 C19orf48 RRP9 SEMA4B PRCC ZMYM3 ACOT8 DDX51 AP4M1 TCEA3 ETV4 BDH1 CBY1 SFN CRCP RRP12 ARMC6 GYS1 FTSJ3 ANGPTL4 RPP25 SMPDL3B TMEM79 ABCA2 CTH NOL12 CBR3 VAC14 PHB BCL3 TAF1C GEMIN2 GADD45A C11orf24 CLTB PTCD1 ECH1 ZBTB32 PLEKHA4 HES7 MED29 EXOSC1 MDN1 ICAM1 ZNF428 KIF18A CHAC1 NEFH MSRB2 SULT4A1 up
## GCNP_SHH_UP_EARLY.V1_UP 0.0014815 0.0084906 0.3859928 1.752254 0 155 JMJD8 CD2BP2 TNNC2 UBE2T NTHL1 RPL39L FAM220A DOLPP1 FEN1 FOXK1 SLC35E1 NVL DCPS KIAA2013 MRPL9 ANKRD13C TMPRSS2 CD55 FTSJ3 GPATCH2 NUP107 UPF3B ARHGAP8 GNL3 SLC27A1 ICAM5 MCM10 KIF4A SHC1 INTS7 TRAIP DHODH FNBP4 UQCC1 OXSM AURKA IRF6 KIF1A ANLN SRSF1 VHL AURKB ATL2 KIF1B GGPS1 SPDL1 CXorf38 ADCY6 HMGCL SNAPC2 DHFR POLA2 FBXO45 TYMS MCM5 ABCB10 CLCN6 CNOT2 FOSL1 CHEK1 BCKDHA STRN3 SDC3 E2F3 CKS2 PARG up
## E2F3_UP.V1_UP 0.0014368 0.0084906 0.3759108 1.735088 0 171 SNRNP25 TLCD1 SBK1 NUDT22 LRRC45 MANEAL RECQL4 CABLES2 MNX1 EMC9 FAXC FEN1 PDXP MFHAS1 ZDHHC12 FBXL16 EEF1A2 MSRB1 TMEM201 KLF16 CMPK2 ATAD2 POLE ANTXRL TSPAN5 TP53I13 SAMD1 ANKRD18A SLC4A3 TPPP MBOAT1 BRI3BP DHRS13 MMP15 PIN1 RHOBTB2 TLE2 SAC3D1 FANCA NAT8L GPR160 PXMP2 NPAS1 NGEF RASD1 JPH1 LIN7B PEG10 RTN4R SYNGR3 RTN4RL1 MAP6D1 KISS1R ZNF367 PCNA SIX5 DDAH1 SMCO4 ABHD15 RASGRP1 TMEM106C CHST2 up
## HOXA9_DN.V1_DN 0.0014184 0.0084906 0.3667078 1.699821 0 176 MACROD1 TRIB3 SCAMP4 DHCR7 NME4 SLC29A2 PFAS MEN1 EXOSC5 NELFCD MPI GADD45GIP1 TBC1D30 CDT1 ZIC1 TRMT2B NUTF2 NET1 MEX3D ATAD2 CBS APOBEC3B TEX264 SREBF1 MVD METTL16 TMCO6 RNASEH2A SHMT1 TOMM34 FANCG SLC1A5 CYP51A1 MCM10 COL9A3 PHLPP1 ECH1 RFWD3 EPS8 RHOBTB3 AGO2 TIPIN ORC1 ALDOC NPY KLHL7 CDC6 BFAR ALDH5A1 CCNK GINS4 CD3EAP VEGFB NCAPD2 WBP2 IGFBP2 ELOVL6 PER2 COCH CEP55 TMEM106C up
## IL15_UP.V1_UP 0.0014184 0.0084906 0.3647216 1.690069 0 174 ELMO3 SPINT1 ZBTB48 PAK6 ZNF205 SLC29A2 NOP2 MAFK CNNM4 TIMM50 SNHG17 LRP8 TNFRSF12A ETV4 GPT TRMU PUS7 PUS1 UTP3 PMM2 SLC7A5 CDH3 PLXNA3 LIF LLGL2 CAPN10 RPP25 APLP1 MPP6 IRS1 C19orf73 CENPT LIME1 IRF2BP1 DHRS3 HOXC8 URB2 ZNF276 SLC1A5 VDR SH2D4A PDE4A TMEM209 ZBTB32 YRDC MFSD12 TNFRSF21 S100A1 up
## CRX_NRL_DN.V1_UP 0.0015408 0.0084906 0.3805377 1.670477 0 123 RHPN1 CNGB1 REEP6 RNF207 PIP4K2C SLC29A2 ZC3H3 DOHH GALNT10 PAQR4 ZDHHC12 ABHD14A LLGL2 SYTL1 CAMK1D DHRS3 TNIP2 KMT2C REC8 GRTP1 RNF123 EPS8L1 GADD45A PTPN18 GFAP ARG2 CKMT1A TNNT1 ALPL KCNJ14 DRD4 MYO7A SNTA1 SSBP4 GPSM2 PRKAB1 KLHL36 CDR2 B4GALT1 PROSER2 CNGA1 BUB1B NRL TFF3 RFX2 PSD RTBDN MC1R up
## SRC_UP.V1_DN 0.0014815 0.0084906 0.3669690 1.665893 0 155 IFI6 PC PHLDA2 CAPN12 C1orf159 PLAT ZNF3 SPRR1B CDK11B IVL KCNMB3 POLR1A GFRA3 ATAD2 PRR19 MCM4 EIF3CL RNF220 ZNF628 CA7 POP1 PRSS33 IFIT1 NOL12 UHRF1 CDCA7 CSAD COQ4 MON1A SYT1 WASH3P SCRN2 LIG1 SPDYE1 IFITM10 DGCR11 HOXB2 GDPD3 RRN3 MCM3 MEGF6 ARSJ IRX5 B3GNT3 MAP3K6 NFKBIE PPIL1 CTDP1 UNC119 EZH2 DISP2 up
## NRL_DN.V1_DN 0.0015576 0.0084906 0.3812757 1.665766 0 120 INPPL1 ACBD6 BSPRY METRN CLPB LAMTOR2 HARS2 GGT7 RNF25 WWC1 TRIM17 RGL3 CDT1 TRAPPC3 LMNB2 TNPO2 TMED9 PRMT1 QSOX1 EN2 GREB1 MPP6 SUPT16H BST2 CTH BAX TUFT1 up
## LEF1_UP.V1_DN 0.0014286 0.0084906 0.3602403 1.664882 0 173 RAB25 MST1L NME3 TFF1 USP18 MVP SLC22A18 TMED3 RABL6 AP1M2 ATP1B1 OAS3 MOCOS PRSS8 TMEM53 RBM47 FOXA1 KCNV1 HERC6 DPP4 ELF3 HAUS4 HCFC1R1 PCP4 CPOX ELL3 FBXL15 KIAA0319L MARC1 OAS1 ENC1 TRPM4 RHOBTB2 SCG5 ACSF2 PITX2 S100A14 PRR15L MXD3 ACSL5 ENTPD3 AGR2 PAK1 GDPD3 HNF1B ATP2A1 GDE1 GALNT12 SORL1 FAM83E ALDH5A1 BDKRB2 CDK3 MLLT3 CCL20 GRB14 EHF ANKFY1 NUDT18 ANK3 SELENBP1 COCH ALCAM TMEM144 PDZK1IP1 up
fgsea_plot(fgsea_res$res_c7, pathways_title='C7 immunologic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ---------------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0014347 0.0039128 0.6981515 3.304729 0 187 TBL3 NOC2L UBN1 SLC25A22 AURKAIP1 EEF1D THOC6 ZNF512B POLD2 QTRT1 MRPS2 TSR3 E4F1 PFDN2 SLC2A4RG WDR18 PDIA4 GCDH HRAS TAF4 TSTA3 CCS RRS1 PRCC PDAP1 OSBPL2 ADRM1 MRPL12 FOXK2 CDK2AP2 NADSYN1 VPS9D1 ABCF3 GADD45GIP1 SDF2L1 BRMS1 IRF3 MFSD10 SART1 EDF1 SF3A2 STK25 AP5Z1 DNAJC17 HMG20B FBXO41 PTBP1 TP53 ATP13A1 UBE2M TMED9 AAMP PRPF19 SSRP1 CDC37 NELFB XAB2 SIGIRR SLC7A5 TMEM259 DAZAP1 PGLS POLR2E NONO COPG1 C9orf16 TRIM28 PPP6R2 SH3GLB2 TECR SPINT2 TACC3 U2AF2 THAP7 RPL36 EXOC7 RALY AMBRA1 RPL37 COPS7B SREBF1 VPS51 HSPA9 ANAPC2 NFKBIB RPL11 DRAP1 BANF1 UBE2S GATAD2A PSMB10 ZBTB17 LRRC41 CLPTM1 SNRNP70 SRRM1 RBM42 PAF1 TAF1C PIN1 DCAF15 FUS IMPDH2 RPS27 RPLP2 SAC3D1 APBA3 SLC39A4 ST6GALNAC4 LSM12 WDR74 MARCKSL1 NDUFC1 SMARCD2 TAF10 ARF5 SNRPF TSSC4 ERP29 PTMA HNRNPA2B1 HNRNPM RAB1B PUF60 PEF1 UCP2 PPIB CFL1 AIP ABHD17A SRSF9 SAFB SNF8 CFDP1 PDIA3 RALGDS SIPA1 CDCA4 ILKAP PEX5 DGKZ up
## GSE45837_WT_VS_GFI1_KO_PDC_DN 0.0014556 0.0039128 0.6553824 3.082952 0 180 SNRNP25 MRPS34 FASTK RBCK1 CD2BP2 TRADD DAP3 ECI1 PSMD4 NDUFS6 RFXANK MPG HDHD3 NTHL1 EBNA1BP2 DECR2 AUP1 LMAN2 MZT2B C7orf26 MPI AHCY NUMA1 COG4 TCF20 LAMTOR2 ENSA PITPNM1 UCKL1 EDF1 LSM7 ZNF32 EPS8L2 MZT2A NPM3 ETFB AAMP PLEKHJ1 PRMT1 EIF3I SHMT2 HSPB1 CCT7 COPS6 NUDT1 NIPSNAP1 ARPC1B DYNLRB1 MPDU1 BCS1L NENF TOR3A DNPH1 DPM3 MRPL23 BST2 DRAP1 RANGRF POLR2F ANXA11 STOML2 CYB561D2 AEN PSMC5 DDX49 SLC35C1 PSMB6 COX6B1 UQCRQ CLASRP CLPTM1 NME1 NDUFS7 GRHPR PSMD13 PIN1 MRPS16 FUS HEMK1 SNRPD2 ECSIT SNRNP35 LCMT1 GNA12 MRPS11 SAE1 DFFB UQCRH EEF2 ARF5 SNRPF PFKP ZNF428 IGBP1 ERP29 HNRNPF UQCR10 CDC42SE1 UQCR11 TBCA POLR2I TRAPPC2L GANAB OCEL1 XRCC6 DDT YARS2 TRMT5 PSMD8 RPS7 NDUFA2 CTDNEP1 PDIA3 COX8A RALGDS SRPK2 MCM5 DALRD3 COPZ1 COX5A SDHC R3HCC1 PSMD9 ARL6IP4 ISG20 UBL5 SOD1 BANP up
## GSE41867_DAY6_VS_DAY8_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN 0.0014556 0.0039128 0.6347529 2.992793 0 185 RPAP1 RCE1 DUS1L NOC2L SLC25A39 AIMP2 UBE2I MTG2 JMJD4 MRPS26 LYPLA2 TMEM177 NUDC BLOC1S4 ZNF213 NOB1 EXOSC5 EIF6 TIMELESS SRPK1 HAGH AHCY GPS1 MFHAS1 CLDN7 LSM7 SLC35B1 POP7 RAD23A HSPA5 NLE1 CCT5 CDK4 BZW2 TRMU UTP3 NUTF2 ALDH18A1 TRMT112 SNHG7 POLR2E COPS6 MRPL52 PPRC1 C19orf53 AAAS MRPL17 DYNLRB1 WDR73 DNPH1 MCM2 NCOA5 YWHAG PAK1IP1 CTH DNAJC2 POP1 PAICS AEN SPRYD4 DDX49 MTRR SRRM1 NME1 NDUFS7 EEFSEC NDUFB9 PSMD13 ORMDL2 TIMM8B SPAG7 TOMM22 SRP54 TMEM209 SPATA5L1 UBOX5 GRPEL1 WDR74 UBAP2 MED29 TNFSF9 DDX39A LIPT2 PHF5A TRIM44 NUP188 MDN1 MCM3 CAND1 NSFL1C FAM118B FASN SF3B5 SUPT3H DNAJB11 SNRPD3 CRELD1 HNRNPM PPIE MSRB2 CD3EAP NDUFA4 COPS7A LARS2 HSPA8 USP10 ACOT7 COPB2 C1orf50 TBC1D10A ELOVL6 up
## GSE37532_TREG_VS_TCONV_CD4_TCELL_FROM_LN_UP 0.0014620 0.0039128 0.6247708 2.943160 0 183 GPATCH4 CLUH TOP1MT BSPRY C7orf50 ATAD3A AIMP2 DDX56 EEF1D YDJC WDR55 METTL1 ECI1 ATIC ALG3 MRPS2 USP39 HDGF CCT6A APRT SRM C19orf48 ECE2 EBNA1BP2 NOP2 NOP14 PRMT5 CCT3 DNAJC11 ZNF239 MFHAS1 GRWD1 MRTO4 SNHG17 TRMT61A SF3A2 NOP56 POLR3E MRPS6 IMPDH1 PRMT1 SHMT2 MUC1 SLC7A5 ALDH18A1 SLC35B2 FTSJ3 ABHD14A TSR1 RRP1B MPHOSPH10 RSL1D1 PARN GAR1 CTPS1 SRP68 MRPL37 DNAJC2 C1QBP HSPD1 EXOSC2 GART PSME3 TMEM147 AEN ACY1 POLR1B SEPHS2 FAH COQ4 CHCHD4 ENDOG TSR2 CLNS1A SURF2 ECSIT DNAH11 DTD1 NOP58 WDR74 TIMM9 TIMM10 SFXN2 GNG3 AHCYL1 SLC35F2 ICAM1 TMEM216 MRPS27 CDC6 WDR3 POLR2I CCDC58 PRDX6 DDT EXO1 DANCR up
## GSE24634_TREG_VS_TCONV_POST_DAY3_IL4_CONVERSION_UP 0.0014728 0.0039128 0.6215287 2.924395 0 182 NUDCD3 DUS1L MRPL24 POLR3K POLD2 ATIC LONP1 TSR3 PFDN2 ISG20L2 WRAP73 NOC4L SRM NTHL1 ATP6V0E2 NPRL3 ENO1 PWP2 PRMT5 RPUSD2 LSM4 HAUS5 CDT1 FAM136A NCL NCAPH2 POP7 RUVBL1 PMPCA TSFM NVL FBXO41 PTBP1 UBE2M IMP4 BZW2 CRCP FIBP HNRNPAB NMT1 NOLC1 EIF3I DTYMK SLC7A5 MYBL2 SGTA MCAT CCT7 POLE TACC3 LIF MRPL17 NUP210 TARBP2 SUPT16H CCT2 ILF2 CDCA8 MRPL23 CTPS1 PLK1 C1QBP HSPD1 EXOSC2 RAD50 MRPS12 RBM28 RNASEH2A NUP93 CS PMAIP1 PABPN1 BCL2L1 MCM10 NCAPG2 LIG1 MKI67 IFT57 COX17 AGO2 UBAP2 GAPDH CIAPIN1 PRPF8 DDX39A CNPY2 NOL9 BYSL CLPP HINT1 KIF18A PRKD2 EZR SNRPD3 HNRNPM AKAP8 DCLRE1A SPDL1 EXO1 SPAG1 CENPF CTDNEP1 NCAPD3 EIF2B3 POLDIP3 ILKAP WDR43 TMEM106C FUT8 MAGOH up
## GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0014684 0.0039128 0.6179580 2.903824 0 181 CBX4 AURKAIP1 RBCK1 THOC6 ZNF512B CAPN15 MVP PPP1R14B LRRC47 NDUFS8 TSR3 PFDN2 MRPS15 WDR18 GID8 PDIA4 APRT IDUA RNPS1 HRAS PRCC NSMF PDAP1 BECN1 ADRM1 MRPL12 FOXK2 NADSYN1 CORO1B AHCY DEAF1 MFSD10 SART1 EDF1 SF3A2 STK25 ILVBL AP5Z1 HMG20B FBXO41 RNF126 PTBP1 TP53 TMED9 GTF2F1 SSRP1 CDC37 XAB2 NUTF2 VPS4A MAP2K2 DAZAP1 SEC61G POLR2E NONO COPG1 C9orf16 SH3GLB2 U2AF2 RALY CHCHD3 RPL37 COPS7B VPS51 HSPA9 DRAP1 UBE2S HNRNPU ADNP2 GATAD2A PSMB10 DDX49 FBXL15 HNRNPUL1 SRRM1 C12orf10 PABPN1 RPLP2 SAC3D1 ECSIT ST6GALNAC4 LSM12 MARCKSL1 NDUFC1 SMARCD2 TAF10 SNRPF BCL7C SLC52A2 RNF19B ZNF580 ERP29 HNRNPM UCP2 MEAF6 BTF3 PKN1 RDH14 CFL1 SUMO3 RPN1 FCHO1 SRSF9 SAFB SNF8 CFDP1 PDIA3 MCUR1 CDCA4 ILKAP DGKZ COX5A R3HCC1 NAA60 up
## GSE21927_SPLEEN_C57BL6_VS_EL4_TUMOR_BALBC_MONOCYTES_DN 0.0014684 0.0039128 0.6140743 2.885574 0 181 CLUH EIF3B UTP14A NOC2L DPP3 DDX56 POLD2 ALG3 MRPS2 DPH2 PSME2 CRELD2 NUDC PDIA4 BLVRA PPM1G HMGA1 TUBG1 PDAP1 LSM4 CLPB GADD45GIP1 POLR2H DNAAF2 RNF25 NHP2 TTLL12 NAT10 C1orf109 MRPS18A PMPCA GNL2 PSAT1 MYL6B DCPS ETFB PRPF19 AATF CLTA PMM2 ALDOA SLC7A5 CIT ATAD2 SNRPE PDCD11 POLR2E NABP2 MRPL52 MCM4 MCM7 NXT1 FKBP4 GSPT1 GTPBP4 ALG8 MNAT1 HSPA9 DNAJC2 POP1 MAPKAPK3 PSMA7 PSME3 UBE2S SLBP STOML2 MRPS12 DDX49 IARS2 URB2 DEF8 UQCRQ PMAIP1 TIMM8B PARP2 MRPL34 SNRNP40 POLR2D GRPEL1 GRSF1 PPAT BUD31 RPSA EIF3A UQCRH NUP188 SNRPF BYSL SLC25A11 TUBA3D RTCB FASTKD3 UTP18 KIF18A MORF4L2 UBE2L3 POLR2I RAC1 XRCC6 HSPA8 PSMD8 AFG3L2 PHGDH COX8A CLPX THOC5 NUP88 MED20 CSNK2A1 up
## GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_DN 0.0014641 0.0039128 0.6108103 2.876164 0 184 TBL3 GPATCH4 CLUH EIF3B NADK BSPRY LETM1 MRPS26 LYPLA2 ZMYND19 SMYD5 NDUFV1 CDC34 SRM TSTA3 SNHG3 SLC25A10 ZNF768 MTOR EIF4G1 AHCY PDZD11 LAS1L CTU2 HMBS NDUFB7 TRMT61A NHP2 EML2 NAT10 GNL2 BZW2 NMT1 FBXO6 EIF3I EIF3G PGLS PPIA NTMT1 PTOV1 MRPL36 CCT7 HDLBP PPRC1 ACACA NQO1 CAD BCKDK PHF23 ALG8 MNAT1 MRPL23 MRPL37 RAD23B ALAD TMEM147 SPRYD4 ACY1 FBXL15 CNDP2 UQCRQ EIF5B NME1 FAF1 PIN1 CYP51A1 TCERG1 LZTR1 ADI1 GCSH CLNS1A GRPEL1 LSM12 SLC35A4 CNIH4 NFS1 RPA3 MBD3 DLL3 PABPC4 CLPP HINT1 UQCR10 WDHD1 BOP1 NUDT5 PMM1 PRDX6 EXO1 CD3EAP FDFT1 DDB1 POLA2 ACADS PCNA POLR1D ATP2A2 C1orf50 WNT10A NAA38 HNRNPA0 CEP55 YIF1B TMEM51 SDHC MAP2K3 PAOX ANAPC1 UBL5 UROD DUT up
## GSE21670_UNTREATED_VS_IL6_TREATED_STAT3_KO_CD4_TCELL_DN 0.0014556 0.0039128 0.6067358 2.860695 0 185 GPATCH4 EIF3B TSPAN17 POLD2 TRMT1 ATIC NOL6 LARP1 ZDHHC9 SRM PFAS RRS1 TFPI2 NOP2 NOP14 EXOSC5 TRAP1 ENO1 CCT3 EIF4G1 RANBP1 AHCY MRTO4 LRP8 APBA2 RUVBL1 DHPS POLR1C GNL2 UBE3C CEACAM1 MET CDK4 TP53 PUS7 HNRNPAB NUP205 RRP12 NOLC1 C12orf66 POLR1A SLC7A5 ALDH18A1 PPRC1 DCTPP1 CAD TACO1 SREBF1 GTPBP4 CCT2 PAK1IP1 CTPS1 C1QBP HSPD1 PAICS HSP90AB1 EPHB4 ZDHHC16 SBNO2 FARSB WDYHV1 CMTM8 RPIA POLR1B HEATR1 URB2 BAZ1A PHB SRPRB GNL3 IMPDH2 BCL6 NARF SCFD2 CTSA TFB2M WDR74 TSPAN3 TMEM65 SFXN2 CISH MRPS25 SFXN4 FAM184A MDN1 BYSL SORD WDR3 DTNBP1 PPIL1 PCED1B up
## GSE43863_NAIVE_VS_MEMORY_LY6C_INT_CXCR5POS_CD4_TCELL_D150_LCMV_DN 0.0014430 0.0039128 0.6048742 2.857623 0 186 TBRG4 MLST8 TBL3 NOP9 DUS1L DPP3 KCTD13 TOP1MT YDJC GIPC1 THOC6 REEP6 WDR4 TXNDC17 ECI1 C1orf122 AK2 TMEM150A TYSND1 SMYD5 NUDC AGRN WRAP73 UBE2J2 APRT SRM ZNF213 RABL6 PDAP1 C1orf53 MTOR THOP1 LAS1L PTGES2 PSMD3 TRMT61A GGA3 NAT10 UBE3C MAP1S FLVCR1 SND1 MRPL27 CHERP NDUFAB1 DDX31 NTMT1 MRPS7 ZNF771 TSPAN5 ACIN1 TIMM13 SUPT6H WDR73 NHLRC1 USP54 ELAC2 DNPH1 GTPBP4 POP1 BAX HSPD1 BOLA3 WDR83 RPS6KA2 SLC23A3 SLC41A1 TMEM248 NUBP1 MTFP1 PNPT1 TMEM41A TRMT6 AACS MFSD5 MRPL34 TMEM183A ELOVL1 GIT1 TMEM209 PPAT LSM12 SCYL3 MED29 TESK1 CISH TRIM44 SNRPF MEA1 WDR3 MDM2 TMEFF1 CLIP1 KPNA6 OPA3 CD3EAP SLC7A1 PDXK CSTF1 MYO19 C1orf50 CCNB1IP1 EIF2B3 THOC5 LUC7L CLCN6 TAF1A FAM162A WDR43 DUSP10 up
## GSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_24H_CD4_TCELL_DN 0.0014620 0.0039128 0.5980124 2.817107 0 183 SNRNP25 FLAD1 DNAJA3 EFNA4 FADD AIFM1 TXNDC17 MTX1 ECI1 PPP1R14B CDK5 CCT6A TK1 TPRN SRPK1 MRPL12 LSM4 FEN1 ZNF239 TIMM50 SDF2L1 CCDC124 MRPS33 MRPS18A NLE1 DCPS PHPT1 ETFB RUVBL2 SND1 ASNS ARMC6 DTYMK CHAF1B SF3B3 THYN1 PRDX4 FTSJ3 MRPL52 RPP25 HIRIP3 DESI1 GAR1 DNPH1 SMKR1 MRPL23 CTPS1 ZNF787 PAICS POLR2F STOML2 PSMB2 COA3 PSMB10 ACY1 PDHA1 RNASEH2A CREB3 BIRC5 PAF1 NUBP1 SLC25A15 VPS25 HDDC3 PAM SCFD2 MFAP1 TIPIN POLE4 GOT2 TPX2 CENPM CCDC34 PRELID1 GSTP1 CLPP MEA1 MLYCD WDR3 MPLKIP RNF8 WDHD1 IMPA2 C20orf27 PPIL1 SLC37A4 BRIP1 ZNF367 SLC7A1 EZH2 LCMT2 POLA2 MCTS1 PSMD8 LMNB1 RBM14 WRAP53 SLC25A43 MCM5 NUP88 MED20 OARD1 NAA38 MRPS28 TMEM106C SNRPG NIF3L1 ATOX1 ORC5 TMEM126B LRRC42 up
## GSE10239_KLRG1INT_VS_KLRG1HIGH_EFF_CD8_TCELL_UP 0.0014535 0.0039128 0.5997879 2.816072 0 177 PSMG3 HOOK2 NOP9 SMG5 PGP TRMT1 NR2C2AP ATIC TYSND1 C1orf174 EIF2B5 C19orf48 SSH3 SNAP47 DDX51 COL9A2 CHCHD1 FDPS NHP2 ARX ETV4 RPS19BP1 TXNL4A MRPL11 HMGXB3 ALDOA SHMT2 SLC7A5 PFKL MRPS7 TRIM28 CHCHD5 TIMM13 MRPL17 DCTPP1 RPL36 ELAC2 JOSD2 DNPH1 ILF2 TPD52L2 ACSF3 MED18 HSPBP1 STOML2 ADCK1 DHRS13 SLC7A6 AARSD1 DLX3 ESRP1 SPRYD4 RCCD1 BATF VAC14 RBFA MRPS35 NME1 OAS1 DHX30 PIN1 CYP51A1 TEAD3 HDAC10 CYB5B NDUFAF2 ADI1 EIF3D DRG2 CDKN2A CUEDC2 POLR2D NAT8L ACAA1 DTD1 ATP4A DDX39A SLC35F2 GLDC PABPC4 ZNF428 SIVA1 TMEM216 NDUFAF6 TOMM20 ADCK5 SLC7A1 SLC25A33 PDSS2 ACOT7 RABEPK KLHDC9 RAE1 FURIN WNK4 FAM162A NUDT19 MRPL44 ALKBH6 POLR2C VDAC1 SIAH2 C1orf216 up
## GSE15624_CTRL_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_DN 0.0014663 0.0039128 0.6128681 2.812647 0 155 DNAJA3 DUS1L NADK UBAP2L TAF6 MYBBP1A CHID1 EEF1D TMEM238 CCDC127 PSME2 COMTD1 PPM1G TRAP1 PWP2 TMEM129 DGAT2 IPO4 PNN PNKD C19orf57 TRAPPC3 LRWD1 LRP8 PLEKHA8 PHLDA3 MSRB1 IMP4 CPSF4 DPP9 CDC37 FIGNL1 SND1 MRPL21 GYS1 ANGPTL4 PPRC1 EFTUD2 MPDU1 RPP25 BCS1L BCKDK PA2G4 KEAP1 NDUFS3 PCK2 MSANTD4 RFX5 HSPBP1 SLBP MRPS12 SLC26A6 C3orf33 SPRYD4 KLHL26 IMP3 HEATR1 SEC23B COX6B1 EIF5A HIBADH PSMD11 SPAG7 PGAP2 SWI5 ECSIT RPN2 TUBG2 CCDC6 AIMP1 MBD3 TUBGCP2 C19orf67 RMDN3 ERI1 SNRPD3 BOP1 XXYLT1 SF3A1 RAB1B CHAC1 TRIM21 RRP15 CELF1 FDFT1 VCP PDXK HEATR3 SPRED1 CACYBP WDR12 up
## GSE42021_CD24LO_TREG_VS_CD24LO_TCONV_THYMUS_DN 0.0014556 0.0039128 0.5955711 2.808055 0 185 DUS1L PRPF6 AURKAIP1 JMJD8 RBCK1 ZFYVE19 ESRRA SLC38A10 MRPL20 LYPLA2 TYSND1 CDK5 CIAO1 ANAPC11 ENO1 VPS72 LMAN2 GOLGA3 RERE ECHS1 PSMD3 GUK1 NSUN2 ARPC1A LMF1 PRKCSH RPP25L BCAT2 GTF2F1 CDC37 GNAS CLTA DAP AKT1 TMEM259 RPUSD4 VAMP8 PCNT PNKP TYMP BAK1 ENO3 MKNK2 DFFA WWP2 NDUFS3 CSNK1G2 XRCC1 STOML2 RAD50 MRPS12 PDHA1 PSMB6 RNASEH2A YIF1A TALDO1 RBM42 NUBP1 SMARCB1 TIMM8B NUP85 RPS5 SEC61A1 SNRPD2 PPFIA4 TMEM179B PTPN18 MFSD5 MRPL34 RPL19 RPS16 CTSA RPL28 STRN4 MAF1 TOR1B ACTL6B SDHB RPL3 PIGX MRPS25 NPEPL1 RASD1 ULK1 FKBP8 MBD3 GBA2 MIPOL1 UBALD2 CLPP MEA1 TFIP11 ERP29 PSME1 CYBA CSK ARHGDIA PPIB U2AF1L4 TBC1D22A URM1 UQCRC1 up
## GSE6674_ANTI_IGM_VS_ANTI_IGM_AND_CPG_STIM_BCELL_DN 0.0014641 0.0039128 0.5961907 2.807324 0 184 TBRG4 DNAJA3 CLPTM1L EIF3B NOC2L MYBBP1A C7orf50 ATAD3A YDJC POLD2 ATIC BMS1 PC ZMYND19 TRIB3 SMYD5 LARP1 CCDC86 NOC4L SRM EBNA1BP2 NOP2 PPAN CCT3 GPS1 SNHG17 NHP2 GEMIN4 SESN2 LRP8 NLE1 BDH1 GNL2 DDX54 CDCA7L PRMT1 SND1 SNRPA ASNS NOLC1 GPT2 NDUFAB1 SLC7A5 EIF3G GADD45G RRP1B ERGIC1 HSPA9 CTPS1 NIP7 C1QBP EXOSC2 KCNK5 PIM3 FARSB AEN AGPAT3 XPOT SHMT1 CNDP2 PHB CHCHD4 FBL TUT1 PDIA6 HEMK1 BCL2L1 HOOK1 GCSH AHCYL2 SPATA5L1 WDR74 CISH HSD17B7 BTG3 EXOSC1 NOL9 SLC52A2 SMYD2 BYSL TMCO3 CAND1 UTP18 NSUN5 ELAVL1 ACLY FAM118B HSPA4 BOP1 CHAC1 up
## GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY6_EFFECTOR_CD8_TCELL_DN 0.0014368 0.0039128 0.5926124 2.805949 0 188 TELO2 RCE1 RPUSD1 YDJC MTG2 DHDDS ADAR PEX16 QTRT1 ITPA MVP RCC1 ALG3 MRPS2 RHOT2 AP1G2 LARP1 STIP1 PES1 PPAN CCT3 DNAJC11 FEN1 DHX37 OAS3 RANBP1 RHBDF1 POLR2H MFHAS1 ECHS1 YKT6 UQCC2 HMBS LSM7 LRP8 PMPCA RAD23A IFI35 FIBP RBMX2 NUP205 MLLT1 WDR5 CNOT11 PPIA POLR2E UPF1 MRPL52 NXT1 FGF13 BCKDK PGAM5 TOR3A FKBP4 TARBP2 TTYH3 GTPBP4 CCT2 CARM1 HSPD1 HSP90AB1 NOL12 EEFSEC FAF1 AAR2 PSMD11 NUP85 CYB5B IMPDH2 TTC1 TMEM183A LCMT1 PPAT WDR74 POLE4 MRPS11 LLGL1 CISH TRIM44 NUP188 SNRPF TCOF1 ZNF653 TMEM216 NSUN5 DOT1L RAB1B PPIE ITFG2 EIF2AK4 SLC7A1 MRPL15 CFLAR YARS2 LARS2 PCNA WDR12 COX10 CPSF1 CIRBP GTF3C6 MAGOH POLR2C KAT2A ENOX2 WDR70 ZCCHC17 up
## GSE16385_MONOCYTE_VS_12H_IL4_TREATED_MACROPHAGE_DN 0.0014620 0.0039128 0.5950567 2.803183 0 183 ABCB9 GLYR1 RHBDL1 FASTK TRIM11 AP3D1 ZBTB48 SH2B1 RNPEP NCLN TUFM TBC1D9B POLRMT RNF31 UBE2Q1 ATXN2L CLCN7 AUP1 MIIP ZNF777 CACNB3 RPS6KA4 PPP1R37 UCKL1 PCYT2 TBX6 TRABD RPS6KB2 SNAPC4 DENND4B FHOD1 GSE1 HMG20B TSC22D4 LRP10 NPM3 UTP3 NELFB MEX3D TMEM259 ARID1A LMF2 CHD4 PHRF1 GNB2 ABCA7 ERGIC1 MLLT6 ZNF384 JOSD2 CENPT NEIL1 MAPK8IP3 CIZ1 KAZALD1 XRCC1 CPSF7 LIPE SLC5A6 MAP3K11 THBS3 ANKRD54 IL27RA SNRNP70 MRPS35 TOMM34 PPP1R12C UBE4B RFX1 LRSAM1 STX4 AKT1S1 PTCD1 CTSA KANSL3 STRN4 NFRKB ZFAND2B ADIPOR1 TESK1 DNAL4 PPP2R3A NUP188 FAM193B FAM20A RNF19B PELO CHRNB1 ZNF653 TFIP11 NIPAL3 ERP29 BFAR MDM2 HDAC7 KLHL36 MND1 OCEL1 CCDC97 GUCD1 LASP1 DDB1 FCHO1 up
## GSE18893_TCONV_VS_TREG_24H_TNF_STIM_UP 0.0014451 0.0039128 0.5982785 2.798899 0 173 PUSL1 NMRAL1 CHID1 MRPL4 GSS AK2 CHTF18 CABLES2 GFER SAPCD2 C19orf48 DDX41 TRAP1 BCL2L12 CYC1 MRPL12 LSM4 RANBP1 PDZD11 MFHAS1 WDR34 HMBS CDT1 TTLL12 CHCHD2 MRPS18A PRDX2 E2F1 DCUN1D5 CCNF ETFB FIGNL1 POLD1 EIF3I MRPL41 NIT2 CIT FAHD2A CHAF1B MYBL2 NUDT1 ERGIC3 MCM4 MCM7 CAD PRKDC MCM2 ILF2 MPV17 BOLA3 RCCD1 UHRF1 CDCA7 RNASEH2A NDUFB9 PSMD13 CDCA5 COQ9 VPS25 CMTM1 ETFA PSMC2 C1orf131 MRPS21 TMEM258 CBR1 COX6C RNF26 GOT2 PPCDC SDHB CCDC34 SFXN4 PTTG1 RTCB FASN TROAP ERI1 CDC6 SPC24 ERI2 SLC37A4 BRIP1 DDT ARMC10 BTF3 CENPN BRCA1 POLA2 PCNA NDUFA2 DHCR24 COX8A CDC25A UBL4A GMNN NUP155 DEPDC1B APOO DUT DARS2 CKS2 RFC4 GINS1 CCNE2 MLLT11 TICRR TPGS2 DBF4 HSPA14 KIF15 KNTC1 PSMC3IP CDC23 C21orf58 NDUFB3 MSH6 up
## GSE21380_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_DN 0.0014684 0.0039128 0.5954046 2.797844 0 181 GLYR1 PYGO2 TELO2 PPP1R35 SLC25A22 ZBTB45 MRPL4 ESRRA C1orf122 EIF2AK1 NCLN TFAP4 FKBP2 C16orf58 SLC29A2 NTN3 NAA40 C1orf159 LMAN2 FOXK2 NT5C THOP1 EIF4G1 ALG1 YKT6 LRP8 AMH FBXO34 CHCHD2 RPS6KB2 TMEM101 SIGMAR1 ACTL10 NLE1 UBE2M TMED9 PLEKHJ1 R3HDM4 REG4 WIZ TNFRSF25 NKX2-1 PLAGL2 GNB2 CDC42BPG NDUFS5 C19orf53 DGKQ PRDX5 ZMAT2 IL31RA MPDU1 TXNDC11 AGAP3 CHRNG CNFN FBXW5 LDB1 PLK1 TOMM40L CDK10 ARAF FAM160B2 UHRF1 SLC5A6 G6PC3 SRPRB SETD1B NDUFAF2 FOXD4L1 ICAM5 TMEM150C TXN2 AKT1S1 RPLP2 TOMM7 TSPAN15 ATG9B FAM120A POC1A CIAPIN1 AKT2 NDUFC1 NINL ARF5 RNF19B ERI3 UBXN1 TBCA TRAPPC2L SAG MDM1 up
## GSE360_L_DONOVANI_VS_T_GONDII_MAC_DN 0.0014368 0.0039128 0.5904145 2.795542 0 188 TELO2 NIT1 AIMP2 FADD POLD2 MUC6 RCC1 ALG3 PC TFAP4 TUFM NME4 HRAS TIMM44 MEN1 TRAP1 ADRM1 HAGH MRPL12 DNAJC11 FEN1 MGRN1 ACD SMURF1 POLR2H MX1 FDPS NHP2 HGS TCF3 IRF7 PRDX2 AATF SNRPA CHERP RUSC1 ST3GAL5 MCCC2 SGTA ILF3 CCT7 CDH1 NONO C9orf16 SPINT2 RALY FAM13A TARBP2 MCM2 TYMP MRPL23 ZWINT MAPKAPK3 NDUFS3 CPOX TMEM147 FAM3A CPNE1 SHMT1 TOMM34 BIRC5 PMAIP1 FLII TCERG1 SNRPD2 PPFIA4 GNB5 SAC3D1 PHLPP1 OVOL3 LPAR2 GBF1 AMPD2 SCAP GAK SNRPF BYSL PFKP PABPC4 RAD9A SIVA1 INPP5B EZR FASN SF1 GNA15 POLR2I RIN1 SEL1L3 SLC37A4 KIF1B EZH2 UQCRC1 PIEZO1 ACADS SAFB CCT4 AFG3L2 GNA11 TYMS up
## GSE45365_WT_VS_IFNAR_KO_CD11B_DC_MCMV_INFECTION_UP 0.0014663 0.0039128 0.6022896 2.793980 0 168 RPAP1 RRNAD1 RCE1 EIF3B MYBBP1A YDJC GIPC1 ESRRA LETM1 CABIN1 ZNF786 CAPN15 NAT9 TMEM150A IDUA RRP9 NTHL1 RPTOR NOP2 CLCN7 PGAP3 BCL9L ALKBH4 TMEM129 PELP1 BET1L UBTF TCEA3 KRI1 PRR12 AMH LMF1 TNPO2 SNX8 DPP9 TRMU WIZ CACTIN NEURL4 CHD4 PPIL2 TSR1 ZNF628 TTC9 HHAT ENO3 CCDC61 LTK CCDC142 HNRNPU CIC AARSD1 NSUN4 SHROOM1 VAC14 HECTD3 SLC35C1 SRRM1 TAF1C RRP7A MEF2D RHOBTB2 NF2 SURF2 IVD RNF26 PRPF8 UQCC1 AZGP1 ALG12 PINX1 PEG10 FBXL14 TCOF1 ADCK5 STAC3 IFI27L2 EZR KLHL36 MAP3K6 GLO1 RIN1 POLG UCP2 ZBTB7A OPA3 PACS1 UNC5CL EXO5 MBTPS1 TBCD PPP1R13B ARHGEF18 CLPX PIP4K2B APOD ZNF79 ZBTB40 RNF126P1 ANXA2P1 RCN3 NT5E DCAF4 DOLK ENOX2 up
## GSE15271_CXCR4_POS_VS_NEG_GC_BCELL_UP 0.0014749 0.0039128 0.6019924 2.791942 0 166 TELO2 COASY TLCD1 DHDDS MECR ALG3 DPH2 SMYD5 APRT RNPS1 DGCR8 NSMF PDXP GRWD1 NDUFB2 ANKRD52 NMT1 ADK IPO9 DNMT1 KHSRP TARBP1 NOLC1 CERS2 DCAF12 SNRPE SF3B3 ILF3 NONO RASGEF1A ASF1B BCS1L ARFIP2 IDH3B BCKDK CTH ZWINT HSPD1 RAD23B ALAD CASP2 MUS81 HMGXB4 VEGFA RPIA RNF216 POLR1B NDUFS7 LSM10 NUBP1 SNRPB GNL3 PSMB3 CHCHD4 FANCG CYB5R1 TMEM41A NDUFAF2 TXN2 APBA3 UBIAD1 MCU MED24 ST6GALNAC4 DDX39A LIPT2 AMPD2 ENDOD1 MRPL10 MIF4GD EIF4EBP1 PABPC4 POLH POLD3 MRPS17 PTMA MTX2 SF3A1 DCAKD NFE2L1 EZH2 TGS1 C9orf64 GOLPH3L PDXK MYO19 POLR1D TADA3 OLA1 WDR12 THNSL1 FAM162A NUDT19 WDR43 ANP32B up
## GSE22589_HEALTHY_VS_SIV_INFECTED_DC_UP 0.0014472 0.0039128 0.5911619 2.783267 0 179 TELO2 DVL1 POLR2J IQCE PPP1R16A DDX23 MPG SAPCD2 USP21 SLC12A9 TRIP6 BTBD2 COA4 NSMF DBNL TIMELESS MRPL12 DOHH PICK1 STUB1 GADD45GIP1 PRMT7 NDUFB10 PNKD STAT6 CDK5RAP3 LRWD1 NCAPH2 LMNB2 DNAJC4 IGFBPL1 POLD1 MLLT1 SIGIRR HAGHL HSPB1 EIF4G3 LAMTOR1 NDUFS5 CHCHD5 PARK7 TIMM13 MRPL17 CLK3 AGAP3 RPL36 ELAC2 SREBF1 VPS51 TJP3 NEIL1 MALAT1 RPL13 LTBR DHRS13 SLC7A6OS COA3 CSNK1E ZNF862 NOL12 BATF POLR3H ANKRD54 CARD11 HYI GRK6 DDX11 ANKRD13D CHCHD4 TCIRG1 SDHAF1 PARP2 PTPN18 RGS14 NR1H2 SNORD104 RILPL1 RAB27A NFIC LLGL1 TMEM160 PAM16 RPS14 MEGF8 SUPT3H XIAP POLR2I VRK3 XRCC6 SLC7A1 CCDC88B CTCF DAPK3 SRPK2 SIPA1 DALRD3 PRDM2 IL4R MED12 GTF3C6 KNSTRN up
## GSE16451_IMMATURE_VS_MATURE_NEURON_CELL_LINE_WEST_EQUINE_ENC_VIRUS_DN 0.0014620 0.0039128 0.5904396 2.781433 0 183 TBRG4 DNAJA3 COASY SLC25A39 DDX56 CCDC137 TLCD1 XPR1 QTRT1 MTX1 CDK5 CCDC86 SRM C19orf48 PFAS RRS1 TRAP1 PWP2 ATP1B1 CLPB MFN2 THOP1 TRUB2 ZNF239 LAS1L SLC39A3 IPO4 TXLNA NSUN2 ARPC1A FAM136A LRP8 LMNB2 MRPS18A POLR1C CCT5 PCBD1 DDX54 SSRP1 IMPDH1 PCCB SND1 TOMM40 GPT2 CISD3 LIG3 ALDH18A1 PLAGL2 TNFRSF18 ACAD9 SPINT2 TSPAN5 MED8 WDR73 TACO1 BCS1L HIRIP3 GFPT1 CAMTA2 MAPKAPK3 HSPBP1 ADNP2 POLR3H URB2 CLN6 ORMDL2 KIAA0100 CHCHD4 LAG3 SLC1A5 PDIA6 VPS25 TOMM22 POLR2D PIGM ZBTB32 SERPINH1 ALKBH2 RAB27A TIMM10 CENPM SFXN4 ORC1 RBM19 CCNB1 FANCE RMDN3 CHAC1 ESPL1 CREB3L2 DHFR NETO2 PHGDH TRIB1 ARV1 LYAR RAE1 WDR12 SEC11C GTF3C6 HOMER1 PSMA3 FUT8 ATOX1 PITPNA C1orf216 FSD1 C3orf14 DDX18 CISD1 up
## GSE15930_NAIVE_VS_48H_IN_VITRO_STIM_CD8_TCELL_DN 0.0014347 0.0039128 0.5875372 2.781132 0 187 EIF3B DPP3 FARSA POLD2 ITPA LONP1 ZNHIT1 CDC34 EIF2B5 RNPS1 UBE2T EIF6 PDAP1 MRPL12 AHCY KIF22 UQCC2 NDUFB7 TMEM208 MRPS33 NCAPH2 GPN2 PSAT1 CDK4 PRDX2 UBE2M CCNF CPSF4 ELOF1 RUVBL2 POLD1 MRPL11 MRPL27 NUTF2 PKM BSG DTYMK ALDOA PRDX4 UBFD1 SSNA1 PFKL PSMA5 MCM7 TIMM13 PHF23 GSPT1 EXOSC10 TFDP1 HSPA9 MRPL51 PSMA7 HSPD1 LRRC59 GART BANF1 UBE2S STOML2 MRPS12 DYNLL2 COA3 SEC23B NUP93 NUBP1 SFXN1 PDCL3 SSR2 RRM2 TIMM8B PDIA6 TNPO3 NUP62 MCM10 PGRMC1 SSBP1 SNRNP40 COX17 MARCKSL1 PHF5A MRPS25 PRELID1 GNPAT SEC13 PABPC4 CLPP FASN CDC6 HSPA4 UQCR11 up
## GSE21360_SECONDARY_VS_TERTIARY_MEMORY_CD8_TCELL_UP 0.0014556 0.0039128 0.5886319 2.775337 0 185 TBRG4 DNAJA3 STAP2 MYBBP1A LETM1 MTX1 RECQL4 BMS1 TRIB3 PSME2 TUFM HDGF TSTA3 JTB TK1 NOP14 EIF6 GMPPA MRPL12 LSM4 PKMYT1 GADD45GIP1 DNAAF2 LSM7 UMPS POP7 MRPS18A PTBP1 PRPF19 PUS1 UTP3 POLD1 MRPL11 TOMM40 ASNS PMM2 ALDOA SF3B2 NIT2 KPTN PLAGL2 PPRC1 PARK7 DCTPP1 TBCE BNIP1 MIS18A MNAT1 MRPL23 NDUFS3 RANGRF PSME3 DNPEP CPOX MRPL48 RAD50 COA3 PDHA1 SEC23B DDX46 NDUFS7 CS GNL3 PSMD13 PMAIP1 CYP51A1 TIMM8B ACO2 TCERG1 ORAI2 GEMIN2 SNRPD2 NCKIPSD MKI67 COX17 SLC12A2 DHODH LSM12 GOT2 SDHB PPIH OXSM UQCRH NUP188 GPI CLPP PAM16 MMACHC MTX2 UTP6 HNRNPM GINS4 CD3EAP TTF2 ALDH1B1 TRIM24 USP10 COX8A GOT1 SLC25A17 RAE1 G0S2 TAF1A REEP4 up
## GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_DN 0.0014347 0.0039128 0.5857593 2.772716 0 187 AIMP2 ZNF282 THOC6 MRPL20 GALE PFAS TK1 TUBG1 STIP1 SRPK1 FEN1 TXLNA UBE2C HMBS UMPS LMNB2 CHAF1A MYL6B FIBP PUS7 GBAP1 DTYMK LIG3 PRDX4 MCM4 MCM7 TIMM13 DCTPP1 NQO1 MCM2 TYMP CDCA8 CTPS1 PAICS PCK2 CCDC51 TP53BP1 KCNK5 TUBA1C SPRED2 BATF ACY1 SHMT1 FAH TALDO1 NME1 BIRC5 SLC25A5 RRM2 FANCG VDR MCM10 MYOF KIF4A SAC3D1 FANCA NCAPG2 LIG1 MKI67 SPATA5L1 PALB2 KIF20A RAB38 PXMP2 PPCDC UQCC1 CDC20 TPX2 HJURP RAD54L RPA3 CENPM KIF2C BYSL CCNB1 CKAP5 KIF18B RAD51D SRSF1 SORD AURKB STT3A ESPL1 FH CTNNA1 BRCA1 DHFR POLA2 PCNA IMMT HMMR ACOT7 DHCR24 MCUR1 BATF3 TYMS GMPPB MCM5 UBL4A CEP55 TMEM106C CENPE C3orf14 PXMP4 DUT KIF23 TXN CISD1 RBBP8 LGMN CKS2 POLE2 RFC4 NCAPH CCNE1 CCNE2 CENPA TOP2A CDC45 CDC25C NUSAP1 ASPM up
## GSE24574_BCL6_LOW_TFH_VS_TCONV_CD4_TCELL_DN 0.0014620 0.0039128 0.5883476 2.771578 0 183 FADD PMVK AIFM1 ECI1 GGCT PARP1 ST14 TM7SF2 PYCR1 FKBP2 CCT6A GALE SRM EBNA1BP2 PFAS TUBG1 ENO1 MRPL28 THOP1 HAX1 TXLNA ECHS1 UMPS BDH1 CHAF1A PCBD1 CDK4 TP53 UBE2M TMED9 BCAT2 TOMM40 SNRPA PKM EIF3I SHMT2 MYBL2 NIPSNAP1 PSMA5 MCM4 PLXNA3 TBCE HIRIP3 MCM2 PLK1 DFFA ZWINT CPOX MRPS12 XPOT YIF1A FAH IDH2 SNRPC PSMD13 SLC1A5 CYB5B IMPDH2 TXN2 TRAIP GAPDH RAD54L RPA3 ORC1 AHCYL1 AURKA GSTP1 MCM3 HADH POLD3 SORD AURKB S100A11 COMT NEFH ESPL1 CTNNA1 TTF2 BUB1B EZH2 NCAPD2 HMGCL LCMT2 DHFR VCP CENPF MELK IMMT HMMR PHGDH COX8A GOT1 TYMS HTATIP2 up
## GSE6269_FLU_VS_E_COLI_INF_PBMC_UP 0.0014771 0.0039128 0.6056556 2.770760 0 153 SLC4A2 GLYR1 RNF40 KCTD13 ISG15 LGALS3BP POLM ADAR AP3D1 CAPN15 IFI6 USP18 LARP1 AGRN MX2 GTPBP2 C16orf58 MARK2 MOGS OAS3 EIF4G1 IRF3 MX1 NFATC2IP C2CD3 ARPC1A TRABD GOLGA2 PI4KB DNAJC4 GSE1 IRF7 IFI35 ATP13A1 CHST12 CMTR1 PKM ACIN1 RSAD2 SUPT6H HERC6 SZT2 TYK2 SMG7 CXXC1 PSME3 MLEC OGDH HECTD3 OAS1 DCTN1 DCAF15 PDIA6 SZRD1 NCOA6 NUP62 SHC1 RPN2 CALR STRN4 RFWD3 XAF1 KDELR1 TRIM14 GAK TRIM38 IFI44L MAU2 COMT NUCB1 ZSWIM8 NBEAL2 ARHGDIA TRIM21 NRBP1 DLGAP4 OAS2 SPATS2L ZBP1 COPS7A LMNB1 USP10 PARP12 ATP2A2 IFI44 TIAF1 PROSER1 ACTN4 GMIP SREBF2 OASL IFITM1 UBA7 MTDH GPATCH8 NPIPA1 IFITM3 up
## GSE24634_TREG_VS_TCONV_POST_DAY5_IL4_CONVERSION_UP 0.0014620 0.0039128 0.5880871 2.770351 0 183 POLR3K CSTF2 AK2 PPP1R14B CCDC86 CCT6A NTHL1 EBNA1BP2 PFAS EMC9 MRPL28 PSD4 NFATC2IP CDT1 ABTB2 B3GNTL1 BDH1 CEACAM1 UBE2M PUS7 SSRP1 RUVBL2 MRPL11 ASNS FAHD2A MYBL2 PSMC3 CCT7 DIAPH1 CD320 C19orf53 TIMM13 CAD NARS2 PSMB4 GSPT1 GTPBP4 SUPT16H ILF2 PLK1 NIP7 DNAJC2 C1QBP PAICS GART PSME3 PPP1CA SLBP RAD50 ARPC5L HEATR1 RNASEH2A EIF5B PHB SNRPC PON2 MRPS16 TCERG1 CYB5B LANCL2 DGUOK UBIAD1 SNRNP40 POLR2D MKI67 TFB2M TRAIP TMEM258 PPAT TIPIN CCDC88C TIMM10 PXMP2 PPCDC DDX39A HJURP SLC35F2 BTG3 NUP188 ICMT NEK2 BRIX1 UBE2L3 GEMIN6 EXO1 RRP15 EZH2 CFLAR NCAPD2 BRCA1 FXN KIF3A OSBPL3 AFG3L2 NCAPD3 GOT1 C12orf43 EIF2B3 ELOVL6 PPIF PSMA3 FSD1 LRRC42 NOP16 SEPHS1 AP2B1 POLQ PRPS1 RFC4 GMPS DUS4L NEIL3 up
fgsea_plot(fgsea_res$res_msg, pathways_title='All signatures', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------------------------------------------ ---------- ---------- ---------- --------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0013387 0.0083666 0.7000836 3.473846 0 308 ZBTB7B ZNF692 HSF4 EIF3B KCTD13 UBAP2L SMG5 ATAD3A PHKG2 FBXL19 ATAD3B SMARCA4 RHBG ZNF598 FBXL18 POLM INTS1 QTRT1 SRCAP FBXO44 CAPN15 RCC1 CC2D1B ZMYND19 ZNF646 ARHGEF11 RNF207 RTKN LARP1 AGRN GFER USP21 SLC12A9 RNPS1 SH3BP5L MARK2 ATXN2L PPM1G SNHG3 EVI5L STK11 SRRM2 MOGS SETD1A SLC52A3 MTOR C7orf26 PDXP MIIP ZNF316 PICK1 LRCH4 MYPOP ABCF3 KAT8 SLC39A3 ZMIZ2 GIGYF1 SRRT SCAF1 TMEM63A LSM14B RANGAP1 L3MBTL2 UQCC2 ZNF444 HIP1R TRABD TRAF2 TCF3 RASSF7 SNAPC4 DENND4B FBXO46 AP5Z1 TMEM86B TNPO2 TMEM201 PTBP1 PHPT1 KMT2D XPO5 GRIPAP1 SETDB1 NPM3 TRMU PUS1 R3HDM4 CMTR1 REXO1 SUN1 ABCC10 EPN1 DAGLB KLF16 KHSRP ERCC2 ARMC6 ZC3H7B CACTIN MAP2K2 TMEM259 GAS5 NEURL4 DAZAP1 ILF3 TRRAP DPH7 FBRSL1 ABCA7 PIP5K1A PPP6R2 PPRC1 TBC1D22B ACIN1 U2AF2 SPPL2B SZT2 FXR2 HPCA CDC42EP1 GGA1 COPS7B ENGASE SMG7 CUL7 TICAM1 MAPK8IP3 POLR2F CSNK1G2 KCNK5 APBA1 GPC2 HNRNPU SBNO2 ZNF202 CIC NSUN4 GATAD2A CSNK1E SYMPK CPSF7 ARPC5L TNK2 HHLA3 ANKRD54 LTB4R URB2 AP5S1 CUL9 CLASRP SNRNP70 DDX11 PPP1R12C ZDHHC24 TAF1C SGSM3 ANKRD13D GRAMD4 CNTROB TEAD3 HDAC10 HIRA MEF2D TECPR1 TNPO3 PABPN1 NUP62 DRG2 WASH3P PPARD MSTO1 APBA3 FANCA LMNA CALR SUGP2 RPL18 BRD1 DHX33 FNBP4 LPAR2 LLGL1 PHF5A AMPD2 MRPS25 MCTP2 TTC13 MBD3 MDN1 ZNF524 GBA2 THOC2 TCHP HAUS8 RBM33 TCOF1 ZNF580 ZNF133 SLC4A11 DOT1L LEMD2 CDC42SE1 SF1 NSUN5P1 HDAC7 up
## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0014837 0.0083666 0.7597568 3.327490 0 105 SNRNP25 MRPS34 TBL3 TELO2 RPUSD1 RHBDL1 C16orf91 WDR24 POLR3K AXIN1 PIGQ JMJD8 TRAF7 UBE2I METRN THOC6 NME3 WDR90 ZNF598 RAB40C NUBP2 CAPN15 WFIKKN1 KCTD5 TSR3 CHTF18 RHOT2 MPG GFER EME2 NME4 ZNF205 ZNF213 NTHL1 CLDN6 PRSS22 NPRL3 CLCN7 DECR2 SRRM2 HAGH PKMYT1 MRPL28 TSC2 PRSS27 STUB1 GNPTG RHBDF1 NDUFB10 PAQR4 KREMEN2 TNFRSF12A LMF1 FBXL16 MSRB1 RAB11FIP3 FLYWCH2 FAHD1 HAGHL RPS2 HCFC1R1 MAPK8IP3 PRSS33 UNKL up
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 0.0013532 0.0083666 0.6809103 3.321499 0 256 CLPTM1L RAB25 BSPRY AURKAIP1 SMARCA4 GIPC1 BAIAP2L1 GSS RABEP2 MVP CC2D1A PWWP2B ST14 EPCAM ABCC3 MROH1 GALE EIF2B5 OXLD1 CCND1 CANT1 CIB1 TSTA3 JTB RABL6 ATP1B1 SRPK1 ZGPAT LMAN2 STARD10 ARRDC1 NADSYN1 DOHH MRPL14 EIF4G1 CRB3 PSD4 PACSIN2 TMEM129 TMEM63A ESRP2 PPDPF DNAJB2 SART1 TMEM30B KRTCAP3 RRBP1 TUBA4A F11R ARHGAP27 HIP1R MLPH EDF1 LSM7 GOLGA2 TTLL12 TMC6 POP7 MRPS18A TRAF4 EPS8L2 RNF126 RASEF MED16 SFN BZW2 ETFB PLEKHJ1 CHMP1A SGPP2 TOMM40 NET1 MT-ATP6 MRPL41 MUC1 QSOX1 CHMP4C TMEM259 MYO6 PPIA SIRT7 BPHL C8orf82 SCAMP2 TMC5 HDLBP MRPL52 MLLT6 LLGL2 C1orf116 NQO1 RALY ELF3 ICA1 FOXQ1 TEX264 TTC22 GFPT1 MFSD9 DHTKD1 FRK TJP3 MKNK2 OVOL2 EPHB4 ARSD ANKRD9 ERBB3 GSTK1 TNIP2 ESRP1 PSMB10 CNPPD1 ARPC5L ELL3 ACY1 TOP1 MYO10 GRTP1 MPST UQCRQ EIF5B TALDO1 PET100 RRP7A RPS6KA1 SGSM3 VPS37B ZMYND8 MARVELD2 C1GALT1 TACSTD2 NDUFAF2 AACS TOX3 SLC22A23 NOSIP ACAA1 KDELR2 NOP58 CCDC107 GPR160 ABHD17C RNF128 AGR2 GSTP1 UBALD2 MGLL AGR3 UQCR11 IMPA2 HM13 DOK4 UNC5CL TMEM125 FDFT1 CTBP2 PLS1 HDAC1 EHF IFI27 GNA11 FUT2 C19orf33 DDAH1 SLC35A3 up
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0014306 0.0083666 0.6981515 3.286612 0 187 TBL3 NOC2L UBN1 SLC25A22 AURKAIP1 EEF1D THOC6 ZNF512B POLD2 QTRT1 MRPS2 TSR3 E4F1 PFDN2 SLC2A4RG WDR18 PDIA4 GCDH HRAS TAF4 TSTA3 CCS RRS1 PRCC PDAP1 OSBPL2 ADRM1 MRPL12 FOXK2 CDK2AP2 NADSYN1 VPS9D1 ABCF3 GADD45GIP1 SDF2L1 BRMS1 IRF3 MFSD10 SART1 EDF1 SF3A2 STK25 AP5Z1 DNAJC17 HMG20B FBXO41 PTBP1 TP53 ATP13A1 UBE2M TMED9 AAMP PRPF19 SSRP1 CDC37 NELFB XAB2 SIGIRR SLC7A5 TMEM259 DAZAP1 PGLS POLR2E NONO COPG1 C9orf16 TRIM28 PPP6R2 SH3GLB2 TECR SPINT2 TACC3 U2AF2 THAP7 RPL36 EXOC7 RALY AMBRA1 RPL37 COPS7B SREBF1 VPS51 HSPA9 ANAPC2 NFKBIB RPL11 DRAP1 BANF1 UBE2S GATAD2A PSMB10 ZBTB17 LRRC41 CLPTM1 SNRNP70 SRRM1 RBM42 PAF1 TAF1C PIN1 DCAF15 FUS IMPDH2 RPS27 RPLP2 SAC3D1 APBA3 SLC39A4 ST6GALNAC4 LSM12 WDR74 MARCKSL1 NDUFC1 SMARCD2 TAF10 ARF5 SNRPF TSSC4 ERP29 PTMA HNRNPA2B1 HNRNPM RAB1B PUF60 PEF1 UCP2 PPIB CFL1 AIP ABHD17A SRSF9 SAFB SNF8 CFDP1 PDIA3 RALGDS SIPA1 CDCA4 ILKAP PEX5 DGKZ up
## LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 0.0014104 0.0083666 0.6847204 3.257227 0 202 SLC4A2 CLPTM1L PYGO2 INPPL1 FASTK DPP3 TAF6 FADD PDCD6 TMEM134 LY6E ADAR PMVK POLR2J CCDC127 METTL1 PPP1R16A NDUFS6 PC ARHGEF11 EGFR CDK5 ABCF2 DHCR7 HDGF USP21 GCDH CCT6A TSTA3 CCS JTB PRCC CLCN2 ALKBH4 B4GALT3 SLC12A7 EIF4G1 HAX1 CORO1B NUMA1 POLR2H PNN RMI2 ZNF3 TDRKH YKT6 ZNF74 NAT10 MBD6 PI4KB RAD23A DENND4B TSFM CCT5 MET CDK4 SETDB1 MAGEF1 IGSF8 FIGNL1 MRPL11 NDUFS2 DAP PARD3 MRPL9 AKT1 CERS2 NKX2-1 DUSP12 SEC61G GNB2 MRPL36 COPS6 LAMTOR1 NUDT1 SDHA PIP5K1A MCM7 PPFIA1 KDM2A PSMB4 DDIT3 TFDP1 ILF2 MRPL23 LPCAT1 PPP1CA DVL3 TUFT1 VEGFA MTRR BAZ1A CCDC85C NUBP1 SSR2 SLC39A1 GEMIN2 LANCL2 POLD4 TMEM191A ZSCAN21 RPS27 SHC1 S100A13 KCNH2 SRP54 PPP1R3D MAF1 MBIP AGO2 CCDC107 TPM3 SRD5A1 PMF1 FAM131A FAM177A1 POGZ MED15 TRIM44 CRKL MIPOL1 JPH1 RTN4R FASTKD3 MRPS17 SIVA1 P2RY6 S100A11 USP13 SNAPIN PUF60 PI4KA up
## CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 0.0013072 0.0083666 0.6407627 3.240698 0 406 RHPN1 ZBTB7B FLAD1 HOOK2 EFNA4 CGN RAB25 RMND5B NOL3 BSPRY ELMO3 JMJD8 DLG3 PKP3 TMEM134 NME3 UBQLN4 RAB40C SPINT1 CAMSAP3 TFF1 NR2F6 RABEP2 SH2D3A GGCT USP18 IQCE PPP1R16A TRIB3 PWWP2B ST14 KIAA1522 TMPRSS13 EPCAM TM7SF2 ABCA12 ISG20L2 TSTD1 ZBTB42 PIP4K2C PROM2 LSR LAD1 SLC29A2 GOLT1A EPHA1 CRABP2 JTB TMED3 ROGDI SSH3 PGAP3 TMEM184A CNNM4 AP1M2 CYB561 SYNE4 ERBB2 LMTK3 SLC52A3 STARD10 ARRDC1 EPN3 TNKS1BP1 RHBDF1 ENSA TBC1D30 PAGR1 ESRP2 FAAH PPDPF CACNB3 PAQR4 TMEM30B SPATA2L F11R CLDN7 ARHGEF5 HIP1R MLPH CYHR1 SUOX ZNF74 PRSS8 OVOL1 GRHL1 TRAF4 CBLC RASEF AAGAB MARVELD3 KIFC2 HID1 MACC1 BCR MPP7 RAB11FIP4 TMEM45B SUN1 FAM110A RUSC1 MRPL41 MUC1 SIGIRR MAP7 CHMP4C MCCC2 TMPRSS2 MYO6 RBM47 SYNGR2 CDH1 SLC37A1 PATZ1 FOXA1 SCAMP2 TLE3 ZNF467 CDH3 PLXNA3 SPINT2 LLGL2 PDXDC1 RAB17 ARFIP2 CHMP2A ANXA9 TTC9 ELF3 ICA1 FKBP4 PRLR GSPT1 SMPDL3B TMEM79 ZXDC TJP3 SYTL1 MKNK2 SYT7 OVOL2 P4HTM GRB7 PCK2 C1orf43 SHANK2 C6orf132 CAPN8 ERBB3 GRHL2 DHRS13 ESRP1 TUFT1 SYMPK MAL2 MREG TNK2 ELL3 COG7 EPHB3 ALDH3B2 OCLN SEPHS2 KIAA0319L TRAPPC6A ARHGAP8 MGMT EXPH5 IDH2 SUCO PLCH1 CSAD BLVRB GRAMD4 MYO5C EPS8L1 TMEM41A MARVELD2 CREB3L4 TADA2B TRPM4 PGAP2 KIAA0556 TP53TG1 TMEM191A FAM214A HOOK1 INPP5J DCAF11 TTC39A S100A14 PRRG4 PRR15L TMEM183A CADPS2 ARFGAP2 TOX3 MSX2 PPP1R3D JUP SLC25A29 MYO5B PPCS SCYL3 PPM1H GPR160 CCDC6 SH3YL1 AGR2 AZGP1 DBP GPR157 ATP2C2 RAB3D ULK1 SFI1 IRF6 SERINC2 MYH14 ERP29 GPD1L PRKD2 MPZL3 CASZ1 GALNT6 IRX5 CXorf40A CDC42SE1 SORL1 ABAT C11orf80 MRFAP1L1 PLXNB1 KRT19 VRK3 ZNF165 SERF2 ALDH4A1 PLEKHA6 CCDC97 up
## CAIRO_HEPATOBLASTOMA_CLASSES_UP 0.0012270 0.0083666 0.6093901 3.180274 0 560 TBRG4 MLST8 EIF3B UTP14A PRPF6 MYBBP1A DDX56 FARSA EEF1D SMARCA4 GTF3C2 ZNF696 NR2F6 GGCT ATIC PARP1 RCC1 NCLN RFXANK EPCAM P4HB AP1G2 ABCF2 PDIA4 CIAO1 CCT6A APRT DDX41 MAD1L1 PFAS HMGA1 RRS1 DGKD TUBG1 TRAP1 TIMELESS CYC1 MAVS ENO1 PRMT5 CCT3 OSBPL2 SRPK1 MRPL12 LSM4 THAP4 SNRNP200 ACTR3B RANBP1 AHCY PSPH GPS1 IPO4 KIF22 UBE2C MRTO4 CDT1 NHP2 MRPS33 DDX27 FAM136A PAXIP1 NCL DDX42 STK25 NAT10 CHCHD2 POP7 RUVBL1 C1orf109 POLR1C NOP56 CBX3 NLE1 CHAF1A DNAJC4 MYL6B CCT5 MAN1B1 CDK4 RNF126 UPK3A CCNF IMP4 POLR3E BZW2 NPM3 AAMP TRMU PUS7 PUS1 GTF2F1 AATF SSRP1 TXNL4A RUVBL2 PRMT1 NUP205 POLD1 DNMT1 NOLC1 BSG DTYMK LIG3 ALDH18A1 CHEK2 DAZAP1 EIF2B4 SF3B3 ILF3 SEC61G PRDX4 TRRAP PDCD11 CCT7 E2F5 NONO TSR1 CPSF6 PSMB5 MRPS7 TRIM28 PTP4A3 HDLBP ERGIC3 MCM4 CCDC47 MCM7 APEX1 RPS21 CAD RPL36 PNKP RSL1D1 PRKDC NUP210 MCM2 MIS18A SNTB1 GTPBP4 SUPT16H MNAT1 CCT2 ILF2 CDCA8 TPD52L2 MAZ PLK1 NIP7 RPL11 C1QBP HSPD1 EXOSC2 TAF12 LRRC59 HSP90AB1 RPL8 DDOST CIZ1 GART UBE2S STOML2 AARSD1 LAPTM4B WDYHV1 CPNE1 HEATR1 RNASEH2A GRK6 MRS2 NUP93 EIF5B PHB NME1 TOMM34 BIRC5 SNRPB RPS3 GNL3 RPL37A RRM2 ARMC9 FBL SMARCB1 PDIA6 TCERG1 NUP85 IMPDH2 LANCL2 GMPR2 RPL24 MCM10 RPLP0 RPL10A KIF4A GCSH DGUOK CLNS1A FANCA NCAPG2 RPL19 RPS16 ARID3A LIG1 MMS19 RPN2 POLR2D PSMF1 RPL28 MKI67 RPL22 RFWD3 SLC39A4 RPL18 KIF20A PPAT RPL18A UBAP2 TIMM9 CIAPIN1 SAE1 ODF2 SAP130 FOCAD DDX39A CDC20 TPX2 KDELR1 HJURP UQCRH GLDC AURKA KIF2C SFI1 MDN1 SMARCC1 BYSL CCNB1 DNMT3A MCM3 OXA1L CKAP5 KIF18B PTK2 PABPC4 PLIN3 ENOPH1 NT5DC2 C8orf33 UTP18 SRSF1 HUWE1 KIF18A RPL14 RPS14 AURKB TOMM20 KPNB1 ACLY NEK2 MRPS27 KLHL7 BUB1 CDC6 WDR3 SUPT3H BOP1 BFAR CRELD1 UTP6 SF3A1 C20orf27 AGBL5 PPA1 PUF60 KRT19 XRCC6 PI4KA PRDX6 SPDL1 GINS4 CREB3L2 CENPN SNRPD1 BUB1B EZH2 MRPL15 NCAPD2 TGS1 CTSV LRPPRC FXN CENPF SRSF9 EIF3H IGSF1 MPZL1 ESF1 HMMR USP10 CCT4 CDC25A CCNB1IP1 SLC35F5 RPS6 OLA1 WDR12 CDCA4 THOC5 PQBP1 CSNK2A1 CPSF1 SNX5 RPL23 HOMER1 NAE1 YEATS2 EIF4E2 RPS8 CHEK1 SMC4 RBM12 NOP16 KIF23 DDX18 CANX TCEA1 MAPKAPK5 DLGAP5 POLR3D SEC23IP AP2B1 UTP20 TASP1 CKS2 HIC2 RFC4 ADSL CCNE1 FKBP10 COIL DLST NDC80 GINS1 KIF14 MTDH EEF1B2 CENPI CENPA HSF1 EMG1 TPGS2 TAF1D EIF2S2 TOP2A NCBP2 RPL4 CDC25C PRC1 DBF4 ACP1 PYGL NUSAP1 KIF15 ASPM KNTC1 CERS6 up
## REACTOME_METABOLISM_OF_RNA 0.0011933 0.0083666 0.6040275 3.178557 0 626 SNRNP25 TYW1 TBL3 UTP14A PRPF6 SMG5 GTPBP3 EDC4 CD2BP2 CSTF2 THOC6 ADAR POLR2J WDR4 QTRT1 METTL1 TRMT1 PSMD4 RPPH1 NOL6 BMS1 TSR3 PSME2 DDX23 USP39 WDR18 ISG20L2 NOC4L RNPS1 RRP9 RPL39L EBNA1BP2 TSEN54 PRCC NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 PRMT5 SRRM2 RRP1 LSM4 SNRNP200 DHX37 EIF4G1 LAS1L POLR2L TNKS1BP1 CTU2 POLR2H PELP1 SRRT SART1 PSMD3 ALYREF TRMT61A NHP2 GEMIN4 NSUN2 TRMT12 LSM7 TRMT44 NCL DDX42 SF3A2 NAT10 SUPT5H POP7 EXOSC6 NOP56 PSMC4 DCPS PTBP1 IMP4 CPSF4 TRMU PUS7 PRPF19 PUS1 GTF2F1 UTP3 TXNL4A NUP205 XAB2 SNRPA CHERP KHSRP ERCC2 SF3B2 AKT1 CNOT11 TRMT112 CTU1 ADAT1 SNRPE PSMC3 SF3B3 HSPB1 CSNK1D PSMA6 PDCD11 POLR2E UPF1 MT-RNR2 FTSJ3 TSR1 PSMB5 PSMA5 PSMD2 ADAT3 RPL38 THOC3 RPS2 AAAS RPS21 U2AF2 EFTUD2 MT-RNR1 NXT1 MPHOSPH10 RPP25 RPL36 LSM5 ELAC2 PARN METTL3 APOBEC3B NUP210 PSMB4 RPL37 NUP107 PRKCA GAR1 GSPT1 EXOSC10 MNAT1 TPR UPF3B SMG7 SRSF4 NIP7 RPL11 CWC25 POP1 PSMA7 PSMC6 EXOSC2 RPL8 PSME3 HNRNPA1 POLR2F EDC3 RPL13 RPLP1 HNRNPU SLBP PSMB2 PSMC5 NSUN4 WDR33 RPL12 RPL36AL CSNK1E SYMPK CPSF7 PSMB10 PAIP1 DDX49 NOL12 RPL35 IMP3 HEATR1 HNRNPUL1 PSMB6 GLE1 RBM28 XPOT NUP93 SNRNP70 DDX46 SRRM1 DHX38 IGF2BP3 LSM10 SNRPB RPS3 SNRPC RRP7A GNL3 DUS2 PSMD13 PSMB3 RPL37A PSMD11 POLR2A FBL FUS NUP85 GEMIN2 PABPN1 RPS5 NUP62 RPS15 RPL24 RPS27 RPLP0 SNRPD2 RPL27 TRMT6 RPL10A PABPC1 RPLP2 RPL27A SF3A3 CLNS1A PSMC2 RPL19 RPS16 ERCC3 SNRNP40 RNPC3 RRP36 POLR2D PSMF1 RPL28 RPL39 RPL41 RPL22 RPS20 NOP58 SNRNP35 RPL18 RPL31 RPL18A RPL30 ZMAT5 BUD31 RPSA TRIT1 GEMIN5 PRPF8 RPS28 FAU SMG8 RPS29 DDX39A RPL3 PAN2 PPIH PHF5A ANP32A EXOSC1 RPS11 NUP188 RPS12 NOL9 SNRPF BYSL THOC2 DHX9 RTCB ZFP36L1 SEC13 TFIP11 RPP38 UTP18 SRSF1 HNRNPF PSME1 RPL14 RPS14 ELAVL1 RPL13A HNRNPA2B1 ERI1 WDR3 SF3B5 SNRPD3 BOP1 SF1 UTP6 PRPF4 POLR2I HNRNPM SF3A1 SUGP1 PPIE PUF60 PPIL1 RPS10 DCAF13 RPL26L1 RPL29 NUP214 RPL32 GEMIN6 U2AF1L4 SNRPD1 UBC PPP2R1A RPS24 URM1 LCMT2 TGS1 CDC5L RPL26 POM121C SRSF9 TRMT5 HSPA8 NUP133 SMG1 PSMD8 RPS7 CHTOP PUS3 CSTF1 RPL35A ZC3H11A RPL9 A1CF TP53RK POLDIP3 RPS6 RAE1 WDR12 THOC5 RPL23A NUP88 ZBTB8OS RBMX RPS4X PDCD7 LTV1 PQBP1 HNRNPA0 TRMT61B IGF2BP1 CPSF1 UBA52 SMG9 WDR43 RPL23 CNOT2 PSMA3 SNRPG MAGOH NUP155 POLR2C RPS15A PSMD9 RPS27A RPS26 GEMIN7 RPS8 TSEN15 NOP10 PSMC1 up
## chr16p13 0.0013369 0.0083666 0.6434804 3.165041 0 272 SNRNP25 MLST8 DNAJA3 MRPS34 TBL3 GLYR1 TELO2 RPUSD1 RHBDL1 C16orf91 WDR24 POLR3K UBN1 NMRAL1 AXIN1 PIGQ JMJD8 TRAF7 UBE2I METRN THOC6 PGP NME3 WDR90 SMIM22 ZNF598 RAB40C NUBP2 ECI1 CAPN15 WFIKKN1 KCTD5 ZNF500 TSR3 E4F1 CHTF18 NUDT16L1 TFAP4 RHOT2 MPG GFER EME2 SLX4 NME4 ANKS3 RNPS1 ZNF205 DNASE1 ZNF213 NTHL1 CLDN6 PRSS22 NTN3 ROGDI NPRL3 TRAP1 CLCN7 DECR2 SRRM2 HAGH SNORD60 PKMYT1 ZNF174 NOMO1 MGRN1 MRPL28 TSC2 PRSS27 ZSCAN32 STUB1 GNPTG RHBDF1 RMI2 ALG1 NDUFB10 PAQR4 KREMEN2 PPL TNFRSF12A LMF1 FBXL16 UBALD1 TPSP2 MSRB1 WASH4P RAB11FIP3 CCNF CCDC154 TBC1D24 DNASE1L2 FLYWCH2 FAHD1 CLEC16A BRICD5 ZNF263 PMM2 HAGHL HMOX2 TMEM186 SNHG9 CARHSP1 RPS2 PDXDC1 AMDHD2 TXNDC11 RSL1D1 PARN METTL22 GSPT1 DDX11L10 HCFC1R1 MAPK8IP3 PDPK1 PRSS33 UNKL MIR5587 WASIR2 MIR3176 ABCC6 NUBP1 PRSS41 TIGD7 ABCC6P2 ABCC1 NAGPA CREBBP IL9RP3 GNG13 CLDN9 ADCY9 ZC3H7A IFT140 RRN3 TEKT5 BAIAP3 CASKIN1 SPSB3 COX6CP1 SYNGR3 ABCA17P PAM16 IMPDH1P11 NOMO3 BFAR ABAT MIR3177 up
## MORF_CSNK2B 0.0013532 0.0083666 0.6442145 3.145761 0 258 SLC4A2 TBL3 EIF3B UBAP2L RER1 PDCD6 DAP3 AP3D1 GGCT ATIC EIF3C NDUFS8 CTBP1 RNPEP LARP1 TUFM DHCR7 HDGF NDUFV1 PPM1G JTB CYC1 PDAP1 CCT3 LSM4 COMMD4 SEC24C FEN1 SNRNP200 EIF4G1 HAX1 GPX4 TRAPPC3 NHP2 SF3A2 LMNB2 RAD23A CBX3 CCT5 CDK4 MAEA TMED9 FIBP HNRNPAB IMPDH1 RUVBL2 PRMT1 CLTA SNRPA KXD1 NDUFS2 CHERP EIF3I DAP MRPL9 SF3B2 NDUFAB1 MAP2K2 CHD4 SNRPE EIF2B4 ILF3 GNB2 PTOV1 CCT7 NONO NDUFS5 TRIM28 SDHA PRRC2C TECR PARK7 MCM7 RALY PSMB4 ALG8 CCT2 DDX19B SMG7 HSPA9 DOCK3 C1QBP HSPD1 NDUFS3 DDOST RAD23B MPV17 BANF1 PPP1CA TUBB2A TMEM147 PSMB2 DDX49 HNRNPUL1 COA1 COX6B1 DCTN2 CS COX4I1 FBL SLC1A5 FUS COPE AKR7A2 SNRPD2 SSBP1 DGUOK FAM120A COX6C MFAP1 SLC3A2 SDHB NDUFC1 SMARCD2 KDELR1 UQCRH EI24 GPI SEC13 CLPP SRSF1 HUWE1 ERP29 ACLY HNRNPA2B1 COX5B UBE2L3 POLR2I GLO1 SF3A1 GANAB RAC1 PUF60 XRCC6 ESPL1 RHEB ARHGDIA TARDBP PPP2R1A URM1 MBTPS1 UQCRC1 HDAC1 SRSF9 PCNA PSMD8 ACOT7 UQCRC2 CTDNEP1 AFG3L2 RBM14 RBMX ANP32B DRG1 PPP1R7 COX5A SNRPG EIF4E2 VDAC1 PSMD9 up
## REACTOME_RRNA_PROCESSING 0.0014265 0.0083666 0.6629825 3.120259 0 184 TBL3 UTP14A NOL6 BMS1 TSR3 WDR18 ISG20L2 NOC4L RRP9 RPL39L EBNA1BP2 NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 RRP1 DHX37 LAS1L PELP1 NHP2 NCL NAT10 EXOSC6 NOP56 IMP4 UTP3 TRMT112 CSNK1D PDCD11 MT-RNR2 FTSJ3 TSR1 RPL38 RPS2 RPS21 MT-RNR1 MPHOSPH10 RPP25 RPL36 ELAC2 RPL37 GAR1 EXOSC10 NIP7 RPL11 EXOSC2 RPL8 RPL13 RPLP1 NSUN4 RPL12 RPL36AL CSNK1E DDX49 NOL12 RPL35 IMP3 HEATR1 RBM28 RPS3 RRP7A GNL3 RPL37A FBL RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A RPL19 RPS16 RRP36 RPL28 RPL39 RPL41 RPL22 RPS20 NOP58 RPL18 RPL31 RPL18A RPL30 RPSA RPS28 FAU RPS29 RPL3 EXOSC1 RPS11 RPS12 NOL9 BYSL RPP38 UTP18 RPL14 RPS14 RPL13A ERI1 WDR3 BOP1 UTP6 RPS10 DCAF13 RPL26L1 RPL29 RPL32 RPS24 RPL26 RPS7 RPL35A RPL9 RPS6 WDR12 RPL23A RPS4X LTV1 UBA52 WDR43 RPL23 RPS15A RPS27A RPS26 RPS8 NOP10 up
## GO_RIBOSOME_BIOGENESIS 0.0013495 0.0083666 0.6377940 3.116488 0 259 RRNAD1 TBL3 RPUSD1 UTP14A NOC2L MYBBP1A DDX56 MTG2 WDR55 FAM207A MRPL20 NOL6 BMS1 MRPS2 TSR3 WDR18 ISG20L2 NOC4L RRP9 EBNA1BP2 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 EIF6 MALSU1 PWP2 PPAN RRP1 RPUSD2 NOM1 DHX37 DDX51 ERAL1 LAS1L PELP1 GNL3L SART1 URB1 MRTO4 KRI1 NHP2 GEMIN4 DDX27 NAT10 POP7 EXOSC6 NOP56 NLE1 NVL GNL2 DDX54 PIH1D1 IMP4 NPM3 AATF UTP3 VCX MRPL11 ERCC2 NOLC1 DDX31 NGDN TRMT112 PDCD11 MRPL36 FTSJ3 TSR1 MRPS7 ZNF622 RPL38 RRP1B RPS2 RPS21 DROSHA MPHOSPH10 RPP25 RSL1D1 PA2G4 GAR1 GTPBP4 EXOSC10 PAK1IP1 GTPBP10 NIP7 RPL11 C1QBP EXOSC2 MPV17L2 NSUN4 RPL12 METTL16 DDX49 RPL35 IMP3 HEATR1 URB2 RBFA RPLP0P6 RRP7A DHX30 FBL RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A TSR2 RPS16 RRP36 TFB2M NOP58 WDR74 DDX28 RPSA MRPS11 RPS28 YBEY RPL3 MRPL10 EXOSC1 RRN3 MDN1 NOL9 BYSL RPP38 UTP18 ERI3 RPL14 RPS14 NSUN5 BRIX1 ERI1 WDR3 BOP1 UTP6 RPS10 DCAF13 RPL26L1 RRP15 RPS24 ZNHIT6 RPL26 ESF1 RPS7 RPL35A HEATR3 RPS6 LYAR WDR12 RPL23A NUP88 LTV1 TRMT61B up
## REACTOME_TRANSLATION 0.0013441 0.0083666 0.6362028 3.116401 0 262 MRPS34 MRPL55 EIF3B MRPL24 AIMP2 AURKAIP1 FARSA EEF1D MRPL4 TARS2 DAP3 APEH MRPL20 MRPS26 EIF3C MRPL33 MRPS2 MRPS15 TUFM EARS2 EIF2B5 AARS2 RPL39L MRPL12 MRPL14 MRPL28 EIF4G1 ERAL1 GADD45GIP1 HARS2 CHCHD1 MRPS33 MRPS18A TSFM EEF1A2 MRPS6 MRPL11 MRPL27 EIF3I MRPL41 MRPL9 MRPL21 MRPL49 EIF3G TRMT112 EIF2B4 SEC61G MRPL36 MT-RNR2 MRPS7 MRPS5 MRPL52 RPL38 RPS2 MRPL17 RPS21 MT-RNR1 NARS2 RPL36 RPL37 GSPT1 MARS2 MRPL23 SRP68 RPL11 MRPL37 MRPL51 RPL8 DDOST RPL13 RPLP1 MRPS23 MRPL48 FARSB MRPS12 RPL12 RPL36AL IARS2 RPL35 EIF5B SRPRB MRPS35 RPS3 MRPL2 SSR2 MRPL38 RPL37A MRPS16 MRPL3 RPS5 SEC61A1 RPS15 RPL24 RPS27 RPLP0 EIF3D RPL27 RPL10A PABPC1 RPLP2 RPL27A MRPL34 RPL19 RPS16 SRP54 RPN2 MRPS21 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA MRPS11 AIMP1 RPS28 PARS2 FAU RPS29 RPL3 MRPS25 MRPL10 EIF3A RPS11 EEF2 RPS12 OXA1L EIF4EBP1 MRPS17 RPL14 RPS14 RPL13A MRPS27 PPA1 RPS10 RPL26L1 RPL29 RPL32 RPS24 MRPL15 MRPL54 YARS2 RPN1 RPL26 EIF3H LARS2 PTCD3 RPS7 RPL35A RPL9 MRPL43 EIF2B3 RPS6 FARS2 RPL23A RPS4X MRPS28 UBA52 SEC11C RPL23 MRPL44 RPS15A RPS27A RPS26 RPS8 up
## LI_AMPLIFIED_IN_LUNG_CANCER 0.0014409 0.0083666 0.6644600 3.098734 0 167 EEF1D PDCD6 UBE2I LGALS3BP SPINT1 TFF1 SLC22A18 EIF3C MDK ABCC3 P4HB TUFM HDGF PHLDA2 APRT NME4 TSTA3 CRABP2 JTB ENO1 CCT3 ATP1B1 ERBB2 CDK2AP2 HAX1 UBE2C HSPA5 CBX3 EEF1A2 TRAF4 CCT5 SFN TRIM2 PKM DAP ALDOA MUC1 SLC7A5 SNRPE SYNGR2 HSPB1 PRDX4 SOX4 CD46 CDH1 TRIM28 SDHA RPL38 RPS2 SPINT2 SCNN1A RPS21 NQO1 PTPRF DPP7 PSMB4 RPL37 HSPD1 RPL8 DDOST ERBB3 RPL13 LAPTM4B VEGFA TOP1 RPL35 YIF1A LCN2 TALDO1 NME1 UGDH IDH2 RPL37A ENC1 RPS5 RPS27 SNRPD2 RPL27 RPL10A PABPC1 RPL27A RPS16 KRT7 GALNS RPL28 CALR JUP RPS20 CKAP4 RPL31 RPL30 CLDN9 ASCL1 MARCKSL1 KDELR1 UQCRH AKR1A1 GPI PFKP up
## GO_MITOCHONDRIAL_PROTEIN_COMPLEX 0.0013986 0.0083666 0.6441491 3.092113 0 217 MRPS34 MRPL55 MRPL24 MRPL4 DAP3 MRPL20 MTX1 FOXRED1 MRPS26 NDUFS6 MRPL33 NDUFS8 MRPS2 MRPS15 POLRMT NDUFV1 CYC1 MALSU1 CHCHD10 MRPL12 DNAJC11 MRPL14 MRPL28 TIMM50 AGK MT-CYB ANKZF1 NDUFB10 NDUFB2 NDUFB7 MRPS33 MRPS18A PMPCA MT-ND4L ROMO1 SPG7 MRPS6 MT-ND3 MRPL11 MT-ND2 TOMM40 MRPL27 NDUFS2 MT-ATP6 MRPL41 MRPL9 NDUFAB1 MRPL21 MCCC2 MRPL49 MT-ND4 MRPL36 NDUFS5 MRPS7 SDHA MRPS5 MRPL52 MT-ATP8 MT-ND5 TIMM13 MRPL17 MT-ND1 BCS1L CHCHD3 BCKDK MRPL23 MRPL37 MRPL51 BAX TOMM40L NDUFA1 NDUFS3 MPV17L2 MRPL48 MRPS12 NSUN4 COA3 MICU1 NDUFV3 UQCRQ NDUFA13 MRPS35 NDUFS7 NDUFA11 NDUFB9 MRPL2 COX4I1 MRPL38 PNPT1 MRPS16 MRPL3 TIMM8B TOMM22 MRPL34 MCU MRPS21 TOMM7 GRPEL1 TIMM9 MRPS11 TIMM10 SDHB NDUFC1 MRPL10 UQCRH MT-CO1 PAM16 MRPS17 NDUFB1 TOMM20 MRPS27 UQCR10 C12orf65 MTX2 TIMM17A POLG CHCHD6 MRPL15 UQCRC1 MRPL54 NDUFA4 C15orf48 IMMT MCCC1 UQCRC2 NDUFA2 AFG3L2 CLPX MRPL43 MRPS28 NDUFA10 PPIF MRPL44 COX5A SDHC VDAC1 up
## MANALO_HYPOXIA_DN 0.0013569 0.0083666 0.6281606 3.078748 0 270 TELO2 UTP14A POLR3K AIMP2 FAM86C1 LETM1 WDR4 POLD2 ATIC PARP1 NCLN TTLL4 DDX23 USP39 ABCF2 DHCR7 CIAO1 SRM RRP9 RPL39L EBNA1BP2 PFAS HMGA1 RRS1 TUBG1 PWP2 PRMT5 RRP1 SLC25A10 AKAP1 PKMYT1 CLPB FEN1 MFN2 RANBP1 POLR2L IPO4 PRMT7 SRRT GRWD1 URB1 HMBS MRTO4 GGT1 PCYT2 FAM136A LRP8 NAT10 UMPS POP7 RUVBL1 LMNB2 RSAD1 NOP56 TSFM NLE1 NVL CHAF1A CCNF PUS1 NUP205 NOLC1 ARMC6 DDX19A ILF3 TSR1 RRP1B MCM4 ASF1B CAD NARS2 AMDHD2 BCS1L SNAPC5 PA2G4 TOR3A MCM2 GTPBP4 METTL2B MAZ PAK1IP1 CTPS1 POMT2 C1QBP ZWINT EXOSC2 GART PSME3 UBE2S HNRNPU MRPS12 PAIP1 NOL12 SLC5A6 HEATR1 URB2 RBM28 DDX11 PHB NME1 SLC25A15 PSMD11 RRM2 FANCG SLC1A5 FUS NUP85 GEMIN2 MCM10 PARP2 GCSH PPARD SCLY UBIAD1 FBXO42 PPAT WDR74 TIPIN DGCR11 STIL TPX2 HJURP NUP188 BYSL MCM3 GPD1L FASN TUBGCP4 CDC6 BOP1 C20orf27 ELK1 FERMT1 SPDL1 GEMIN6 EXO1 CD3EAP UCHL5 CENPN RRP15 SNRPD1 BRCA1 DHFR FXN MELK POLA2 DHCR24 NCAPD3 HEATR3 CPN2 EIF2B3 MCM5 WDR12 SAR1B ELOVL6 GMNN PPIF NEK4 NIF3L1 MAP2K3 NOP16 NASP KIF23 DDX18 CISD1 SEC23IP UTP20 POLE2 PRPS1 TUBB4B CCNE1 MRPL46 GINS1 CCNE2 up
## GSE45837_WT_VS_GFI1_KO_PDC_DN 0.0014347 0.0083666 0.6553824 3.074079 0 180 SNRNP25 MRPS34 FASTK RBCK1 CD2BP2 TRADD DAP3 ECI1 PSMD4 NDUFS6 RFXANK MPG HDHD3 NTHL1 EBNA1BP2 DECR2 AUP1 LMAN2 MZT2B C7orf26 MPI AHCY NUMA1 COG4 TCF20 LAMTOR2 ENSA PITPNM1 UCKL1 EDF1 LSM7 ZNF32 EPS8L2 MZT2A NPM3 ETFB AAMP PLEKHJ1 PRMT1 EIF3I SHMT2 HSPB1 CCT7 COPS6 NUDT1 NIPSNAP1 ARPC1B DYNLRB1 MPDU1 BCS1L NENF TOR3A DNPH1 DPM3 MRPL23 BST2 DRAP1 RANGRF POLR2F ANXA11 STOML2 CYB561D2 AEN PSMC5 DDX49 SLC35C1 PSMB6 COX6B1 UQCRQ CLASRP CLPTM1 NME1 NDUFS7 GRHPR PSMD13 PIN1 MRPS16 FUS HEMK1 SNRPD2 ECSIT SNRNP35 LCMT1 GNA12 MRPS11 SAE1 DFFB UQCRH EEF2 ARF5 SNRPF PFKP ZNF428 IGBP1 ERP29 HNRNPF UQCR10 CDC42SE1 UQCR11 TBCA POLR2I TRAPPC2L GANAB OCEL1 XRCC6 DDT YARS2 TRMT5 PSMD8 RPS7 NDUFA2 CTDNEP1 PDIA3 COX8A RALGDS SRPK2 MCM5 DALRD3 COPZ1 COX5A SDHC R3HCC1 PSMD9 ARL6IP4 ISG20 UBL5 SOD1 BANP up
## GO_RIBOSOMAL_SUBUNIT 0.0014430 0.0083666 0.6574170 3.070992 0 172 MRPS34 MRPL55 MRPL24 MRPL4 DAP3 MRPL20 MRPS26 MRPL33 MRPS2 MRPS15 RPL39L MALSU1 MRPL12 MRPL14 MRPL28 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 NDUFAB1 MRPL21 MRPL49 MRPL36 MRPS7 MRPS5 MRPL52 RPL38 RPS2 MRPL17 RPS21 RPL36 FXR2 RPL37 MRPL23 RPL11 MRPL37 MRPL51 RPL8 RPL13 RPLP1 MPV17L2 MRPL48 MRPS12 NSUN4 RPL12 RPL36AL RPL35 MRPS35 RPLP0P6 RPS3 MRPL2 MRPL38 RPL37A MRPS16 MRPL3 RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A MRPL34 RPL19 RPS16 MRPS21 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA MRPS11 RPS28 RPS29 RPL3 MRPL10 RPS11 RPS12 MRPS17 RPL14 RPS14 RPL13A MRPS27 C12orf65 RPS10 RPL26L1 RPL29 RPL32 RPS24 MRPL15 MRPL54 RPL26 MCTS1 RPS7 RPL35A RPL9 MRPL43 RPS6 RPL23A RPS4X MRPS28 UBA52 RPL23 MRPL44 RPS15A EIF2D RPS27A RPS26 RPS8 up
## MORF_SOD1 0.0013459 0.0083666 0.6279866 3.065580 0 247 SLC4A2 TBL3 EIF3B UBAP2L AIMP2 PDCD6 GGCT ATIC EIF3C NDUFS8 NUDC LARP1 TUFM NDUFV1 PPM1G CYC1 CCT3 LSM4 FEN1 SNRNP200 HAX1 ENSA FDPS TRAPPC3 NHP2 RAD23A CBX3 CCT5 CDK4 FIBP HNRNPAB RUVBL2 PRMT1 SNRPA KXD1 NDUFS2 CHERP EIF3I DAP MRPL9 SF3B2 NDUFAB1 MAP2K2 SNRPE EIF2B4 ILF3 SEC61G PRDX4 CCT7 NONO NDUFS5 TRIM28 SDHA TECR PARK7 PSMB4 GSPT1 ALG8 CCT2 ILF2 SMG7 HSPA9 DOCK3 C1QBP HSPD1 NDUFS3 RAD23B MPV17 BANF1 PPP1CA HNRNPU STOML2 TMEM147 PSMB2 DDX49 PSMB6 COA1 XPOT NME1 DCTN2 CS COX4I1 FBL MRPL3 FUS AKR7A2 PGRMC1 SSBP1 ETFA DGUOK CLNS1A MAML1 FAM120A COX6C MFAP1 SLC3A2 NDUFC1 SMARCD2 UQCRH EI24 AHSA1 CCNB1 SEC13 UTP18 SRSF1 HUWE1 ACLY HNRNPA2B1 HSPA4 MORF4L2 UBE2L3 TBCA POLR2I GLO1 GANAB RAC1 PUF60 RHEB TARDBP PPP2R1A C6orf62 LRPPRC SRSF9 HSPA8 PCNA CFDP1 PSMD8 ACOT7 UQCRC2 CTDNEP1 AFG3L2 RBMX ANP32B DRG1 TMEM106C PPP1R7 COX5A PSMA3 RPA1 SNRPG EIF4E2 MAGOH ATOX1 VDAC1 PSMD9 up
## MORF_AATF 0.0014164 0.0083666 0.6480427 3.062156 0 191 AIMP2 UBE2I DAP3 MTX1 BMS1 ALG3 TFAP4 WDR18 NUDC TUFM EIF2B5 RNPS1 EIF6 CYC1 DNAJC11 MTOR PKMYT1 SNRNP200 MFN2 THOP1 TXLNA SRRT PSMD3 TRAPPC3 LSM7 NCL RUVBL1 RAD23A GNL2 PRKCSH FIBP AATF HNRNPAB SSRP1 NELFB RUVBL2 SNRPA KXD1 EIF3I MRPL9 SGTA TRRAP COPS6 KDM3B NONO PSMD2 SDHA XPO6 CAD RALY PRKDC IDH3B BRD8 MCM2 SMARCC2 CCT2 ILF2 MLEC TP53BP1 HNRNPU CNPPD1 DDX49 PSMB6 PHB SRRM1 DHX38 CS PSMB3 COQ9 PIN1 POLR2A FUS PABPN1 NUP62 SSBP1 CLNS1A MMS19 ARFGAP2 PRPF8 DDX39A SDR39U1 AHSA1 NUP188 GTF2A2 OXA1L RTCB PABPC4 TCOF1 HADH HUWE1 ACLY HNRNPA2B1 UBE2L3 TIMM17A POLR2I PUF60 CSK ALDH4A1 RPN1 DDB1 LRPPRC SFSWAP HSPA8 SAFB IMMT CTDNEP1 CCT4 AFG3L2 CLSTN1 MCM5 DRG1 NAE1 POLR2C KAT2A IK DDX18 CANX SERP1 ATXN10 TCEA1 PRKAG1 ADSL NAP1L4 KHDRBS1 EIF3K TERF2IP up
## GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 0.0014684 0.0083666 0.6667527 3.061411 0 152 MRPS34 MRPL55 MRPL24 MRPL4 DAP3 MRPL20 MRPL33 MRPS2 MRPS15 RPL39L MRPL12 MRPL14 MRPL28 MRPS33 MRPS18A MRPS6 MRPL11 MRPL27 MRPL41 MRPL9 MRPL21 MRPL49 MRPL36 MRPS7 MRPS5 MRPL52 RPL38 RPS2 MRPL17 RPS21 RPL36 RPL37 MRPL23 RPL11 MRPL37 MRPL51 RPL8 RPL13 RPLP1 MRPS23 MRPS12 RPL12 RPL36AL RPL35 MRPS35 RPLP0P6 RPS3 MRPL2 RPL37A MRPS16 MRPL3 RPS5 RPS15 RPL24 RPS27 RPLP0 RPL27 RPL10A RPLP2 RPL27A MRPL34 RPL19 RPS16 MRPS21 RPL28 RPL39 RPL41 RPL22 RPS20 RPL18 RPL31 RPL18A RPL30 RPSA MRPS11 RPS28 RPS29 RPL3 MRPS25 MRPL10 RPS11 RPS12 MRPS17 RPL14 RPS14 RPL13A RPS10 RPL26L1 RPL29 RPL32 RPS24 MRPL15 MRPL54 RPL26 RPS7 RPL35A RPL9 MRPL43 RPS6 RPL23A RPS4X UBA52 RPL23 RPS15A RPS27A RPS26 RPS8 up
## MORF_BUB3 0.0013514 0.0083666 0.6284570 3.058456 0 243 UBAP2L EDC4 DAP3 AK2 RNPEP NUDC TUFM NDUFV1 SRM PPM1G CYC1 CCT3 LSM4 DNAJC11 SEC24C FEN1 SNRNP200 THOP1 HAX1 RANGAP1 TRAPPC3 LSM7 NCL SF3A2 LMNB2 RAD23A CBX3 CHAF1A CCT5 TMED9 FIBP AATF HNRNPAB SSRP1 TXNL4A IMPDH1 RUVBL2 SNRPA KXD1 NDUFS2 DNMT1 CHERP KHSRP EIF3I MRPL9 SF3B2 MAP2K2 SNRPE ILF3 CCT7 NONO NUDT1 NDUFS5 TRIM28 SDHA PARK7 MCM7 CAD RSL1D1 PRKDC BRD8 MCM2 TFDP1 CCT2 DDX19B ILF2 HSPA9 DOCK3 ZWINT NDUFS3 PAICS DDOST UBE2S HNRNPU SLBP PSMB2 DDX49 HNRNPUL1 XPOT SRRM1 CS FBL SLC1A5 FUS PDIA6 IMPDH2 TNPO3 AKR7A2 SSBP1 DGUOK GOT2 PRPF8 SDHB NDUFC1 ANP32A UQCRH EI24 AHSA1 NUP188 GTF2A2 MCM3 PABPC4 CLPP HADH SRSF1 ERP29 AURKB ACLY HNRNPA2B1 MRPS27 BUB1 UBE2L3 POLR2I HNRNPM GLO1 GANAB PPIE CSK XRCC6 ESPL1 RHEB FH TARDBP PPP2R1A UQCRC1 LRPPRC HDAC1 POLA2 SRSF9 SAFB PCNA IMMT PSMD8 CTDNEP1 AFG3L2 TYMS MCM5 RBMX ANP32B DRG1 NAE1 VDAC1 SOD1 NASP DUT SREBF2 SERP1 ATXN10 TCEA1 RFC4 GMPS KHDRBS1 MTDH up
## MORF_PHB 0.0014663 0.0083666 0.6910981 3.056782 0 113 OTUB1 MTX1 IGSF9B BMS1 SH2B1 TFAP4 WDR18 ADAM15 PCGF1 CIB1 TSTA3 EIF6 PKMYT1 B4GALT3 MFN2 MRPL28 FDXR PSD4 ERAL1 SRRT RABGGTA PSMD3 ILVBL GNL2 PRKCSH BAHD1 HMG20B CPSF4 WDR62 AATF NELFB CSNK1D BPHL COPS6 PSMD2 XPO6 CAD PARN TPR ILF2 PCGF2 SPRN MCRS1 MLEC TP53BP1 RPRD2 CNPPD1 PSMB6 GRK6 MPST DDX11 PHB TOMM34 CS POLR2A FANCG PABPN1 NUP62 BRD3 DRG2 NFRKB LSM12 CHD3 PRPF8 SDR39U1 NUP188 TUBGCP2 SLC25A11 RTCB PLIN3 TCOF1 MEA1 TIMM17A ELK1 ALDH4A1 DDB1 SFSWAP CCT4 AFG3L2 up
## SANSOM_APC_TARGETS_REQUIRE_MYC 0.0013966 0.0083666 0.6382462 3.054261 0 209 TELO2 MYBBP1A GTPBP3 GIPC1 WDR4 QTRT1 METTL1 ZBTB48 PPP1R14B DPH2 ZMYND19 SMYD5 SAPCD2 CCDC86 SRM RRP9 SLC29A2 ZNF213 SMPD4 TK1 TIMELESS PPAN NELFA THOP1 GAS8 KNOP1 D2HGDH WDR34 GRWD1 MUTYH ZNF444 ZSWIM3 TRMT61A NHP2 LRP8 TNFRSF12A ARX LMNB2 SIGMAR1 NOP56 RAD23A FHOD1 DUS3L CDK4 TP53 WDR62 SRD5A3 NOLC1 POLR1A DTYMK RCC2 SHMT2 SLC35B2 ADAT1 HAGHL NTMT1 PTOV1 SOX4 CCT7 POLE MCM7 AAAS CAD GAR1 LDB1 SYTL1 METTL2A RANGRF TUBB2A FARSB MUS81 DDX49 RNASEH2A SHMT1 EMC8 NME1 PRSS41 AAR2 MRPL38 FBL RAI14 HIRA LANCL2 TMEM141 DRG2 ANKRD39 STOML1 ATG9B CREBBP RPL31 IFFO2 ALKBH2 GEMIN5 CDC42BPA TXNRD2 NFS1 RAD54L EXOSC1 MBD3 MDN1 SNRPF SMARCC1 MCM3 DENND6B PABPC4 TFIP11 SIVA1 NSUN5 EPHB2 LHPP MVK NBEAL2 PMM1 USP20 VEZT BUB1B ERCC1 SLC1A4 CITED1 SFSWAP PDXK HES6 RNASEH2C CCT4 PHGDH TRIB1 DDAH1 TP53RK up
## GO_RIBONUCLEOPROTEIN_COMPLEX 0.0011891 0.0083666 0.5794230 3.051669 0 630 SNRNP25 MRPS34 TBL3 TERC MRPL55 EIF3B MRPL24 UTP14A NOC2L PRPF6 SMG5 CD2BP2 MRPL4 PKP3 DAP3 FAM207A ADAR MRPL20 MRPS26 PABPC1L NOL6 EIF3C BMS1 MRPL33 MRPS2 DDX23 USP39 MRPS15 LARP1 NOC4L SNORA74A RRP9 DDX41 RPL39L EBNA1BP2 RRS1 NOB1 NOP14 PES1 EIF6 MALSU1 PWP2 PPAN SRRM2 RRP1 MRPL12 LSM4 SNRNP200 MRPL14 MRPL28 EIF4G1 LAS1L PNN GNL3L SART1 MRTO4 ALYREF KRI1 NHP2 GEMIN4 MRPS33 LSM7 NCL SF3A2 NAT10 GTF3C1 POP7 CELF5 DIS3L2 RUVBL1 MRPS18A NOP56 NVL PIH1D1 IMP4 XPO5 MRPS6 PRPF19 UTP3 HNRNPAB RBMX2 TXNL4A RUVBL2 SND1 XAB2 MRPL11 MRPL27 SNRPA NOLC1 PPP1R8 EIF3I MRPL41 MRPL9 CACTIN SF3B2 NDUFAB1 MRPL21 NGDN TRA2A MRPL49 EIF3G HTATSF1 DAZAP1 SNRPE SF3B3 ILF3 PSMA6 PDCD11 MRPL36 UPF1 FTSJ3 TSR1 CPSF6 MRPS7 ZNF622 MRPS5 MRPL52 RMRP RPL38 RRP1B EIF3CL RPS2 MRPL17 RPS21 ZMAT2 U2AF2 EFTUD2 IGHMBP2 MPHOSPH10 RPP25 RPL36 LSM5 RSL1D1 RALY FXR2 RPL37 GAR1 TARBP2 ILF2 MRPL23 TERT SMG7 FBXW9 SRP68 NIP7 RPL11 MRPL37 CWC25 MRPL51 POP1 SRA1 RPL8 MCRS1 HNRNPA1 RPL13 RPLP1 MPV17L2 ZNF830 HNRNPU RNF113A MRPL48 SLBP WDR83 MRPS12 NSUN4 RPL12 RPL36AL RPL35 IMP3 HEATR1 AKAP8L PABPC3 RBM28 SNRNP70 SRRM1 RBM42 DHX38 MRPS35 EEFSEC RPLP0P6 LSM10 SNRPB RPS3 PRPF39 MRPL2 SNRPC RRP7A AAR2 MRPL38 RPL37A FBL PNPT1 MRPS16 MRPL3 FUS MKRN3 GEMIN2 PABPN1 RPS5 NUP62 RPS15 RPL24 RPS27 RPLP0 EIF3D SNRPD2 RPL27 RPL10A PABPC1 TEP1 RPLP2 RPL27A SF3A3 MRPL34 RPL19 RPS16 SNRNP40 RNPC3 SRP54 MRPS21 RRP36 DHX8 RPL28 RPL39 RPL41 CALR RPL22 RPS20 NOP58 SNRNP35 RPL18 MFAP1 RPL31 AGO2 RPL18A WDR74 RPL30 ZMAT5 CSNK1A1 BUD31 RPSA GAPDH MRPS11 PRPF8 RPS28 RPS29 RPL3 PPIH PHF5A MRPL10 EIF3A RPS11 EEF2 DDX53 RPS12 SNRPF BYSL LARP4B DHX9 ZFP36L1 PABPC4 CCDC12 TFIP11 RPP38 UTP18 SRSF1 MRPS17 HNRNPF RPL14 RPS14 ELAVL1 RPL13A HNRNPA2B1 MRPS27 C12orf65 ERI1 WDR3 SF3B5 SNRPD3 BOP1 SF1 UTP6 PRPF4 HNRNPM DHX29 SF3A1 SUGP1 SLIRP PPIE PPIL1 RPS10 DCAF13 RPL26L1 RPL29 RHEB TRIM21 EIF2AK4 RPL32 JAKMIP1 BTF3 U2AF1L4 RRP15 SNRPD1 TTF2 CELF1 TARDBP RPS24 MRPL15 MRPL54 ZNHIT6 TGS1 BRCA1 CDC5L RPL26 LRPPRC EIF3H MSI1 PRPF18 HSPA8 MCTS1 RPS7 SNIP1 RPL35A RPL9 RBM14 WRAP53 MRPL43 RBM23 RPS6 WDR12 RPL23A LUC7L RBMX RPS4X PDCD7 LTV1 NAA38 HNRNPA0 MRPS28 IGF2BP1 CELF4 UBA52 CIRBP RPL23 DRG1 MRPL44 CELF3 SNRPG MAGOH RPS15A EIF2D RPS27A RPS26 RPS8 ACTN4 NOP10 up
## MORF_DDB1 0.0013550 0.0083666 0.6312123 3.049451 0 226 SLC4A2 DAP3 OTUB1 MTX1 BMS1 ALG3 SH2B1 TFAP4 WDR18 ADAM15 PCGF1 PDIA4 EIF2B5 ATXN2L CIB1 TSTA3 EIF6 PDAP1 BECN1 FOXK2 GOLGA3 PKMYT1 B4GALT3 SNRNP200 MFN2 MRPL28 FDXR RERE TXLNA SRRT RABGGTA PSMD3 ILVBL GNL2 PRKCSH UBE3C BAHD1 CPSF4 WDR62 AATF HNRNPAB SSRP1 NELFB RUVBL2 KXD1 ERCC2 TTI1 NCOR2 SGTA PRDX4 TRRAP CSNK1D BPHL COPS6 KDM3B NONO PSMD2 SDHA XPO6 PDXDC1 CAD PEX6 PRKDC PARN SNAPC5 IDH3B DNPH1 BRD8 MCM2 SMARCC2 TPR ILF2 PCGF2 SPRN DOCK3 DRAP1 ATG9A MLEC TP53BP1 CSNK1G2 RPRD2 TMED1 PSMB6 YIF1A MPST DDX11 DDX46 PHB TOMM34 CS PIN1 POLR2A FANCG NUP62 BRD3 PARP2 MMS19 NFRKB CHD3 PRPF8 DDX39A SDR39U1 AHCYL1 NUP188 TUBGCP2 SLC25A11 RTCB PLIN3 TCOF1 MEA1 HUWE1 HNRNPA2B1 PRPF4 KPNA6 RAC1 PUF60 ELK1 ALDH4A1 DDB1 LRPPRC SFSWAP ABR HSPA8 CTDNEP1 CCT4 AFG3L2 RANBP3 COX8A CLSTN1 OARD1 CSNK2A1 DRG1 POLR2C KAT2A ACTN4 CETN3 HNRNPL EML3 DDX18 CANX SERP1 HLTF TCEA1 SEC23IP PRKAG1 NAP1L4 KHDRBS1 PARG up
## GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 0.0013072 0.0083666 0.6037857 3.039675 0 382 RRNAD1 TBL3 EIF3B RPUSD1 UTP14A NOC2L NOL3 PRPF6 MYBBP1A DDX56 CD2BP2 MTG2 WDR55 FAM207A ADAR MRPL20 NOL6 EIF3C BMS1 MRPS2 TSR3 DDX23 USP39 WDR18 ISG20L2 NOC4L RRP9 EBNA1BP2 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 EIF6 MALSU1 PWP2 PPAN PRMT5 RRP1 SRPK1 RPUSD2 LSM4 NOM1 SNRNP200 DHX37 DDX51 ERAL1 LAS1L PELP1 PRMT7 GNL3L SART1 URB1 MRTO4 KRI1 NHP2 GEMIN4 DDX27 SF3A2 NAT10 POP7 CELF5 EXOSC6 RUVBL1 NOP56 NLE1 NVL GNL2 DDX54 PIH1D1 IMP4 NPM3 PRPF19 AATF UTP3 TXNL4A VCX RUVBL2 XAB2 MRPL11 ERCC2 NOLC1 EIF3I DDX31 NGDN EIF3G TRMT112 SNRPE PDCD11 MRPL36 FTSJ3 TSR1 CPSF6 MRPS7 ZNF622 RPL38 RRP1B EIF3CL RPS2 RPS21 DROSHA MPHOSPH10 RPP25 RSL1D1 PA2G4 GAR1 TARBP2 GTPBP4 EXOSC10 PAK1IP1 GTPBP10 NIP7 RPL11 C1QBP EXOSC2 HSP90AB1 MPV17L2 NSUN4 RPL12 CPSF7 METTL16 DDX49 RPL35 IMP3 HEATR1 URB2 RBFA RPLP0P6 SNRPB PRPF39 SNRPC RRP7A DHX30 AAR2 FBL GEMIN2 RPS5 RPS15 RPL24 RPS27 RPLP0 EIF3D SNRPD2 RPL27 RPL10A TSR2 SF3A3 CLNS1A RPS16 RRP36 POLR2D TFB2M NOP58 AGO2 WDR74 DDX28 RPSA MRPS11 GEMIN5 PRPF8 RPS28 YBEY RPL3 MRPL10 EIF3A EXOSC1 RRN3 MDN1 NOL9 SNRPF BYSL DHX9 RPP38 UTP18 SRSF1 ERI3 RPL14 RPS14 NSUN5 RPL13A BRIX1 ERI1 WDR3 SNRPD3 BOP1 SF1 UTP6 SF3A1 RPS10 DCAF13 RPL26L1 GEMIN6 RRP15 SNRPD1 CELF1 RPS24 ZNHIT6 TGS1 RPL26 SFSWAP SRSF9 EIF3H PRPF18 MCTS1 ESF1 RPS7 RPL35A HEATR3 SRPK2 RPS6 ATR LYAR WDR12 RPL23A LUC7L NUP88 RBMX LTV1 TRMT61B CELF4 up
## GO_NCRNA_PROCESSING 0.0013263 0.0083666 0.6087856 3.038155 0 325 RRNAD1 TYW1 TBL3 DUS1L RPUSD1 UTP14A PUSL1 POLR3K GTPBP3 DDX56 WDR55 CSTF2 TRPT1 FAM207A INTS1 ADAR WDR4 QTRT1 METTL1 TRMT1 NOL6 BMS1 TSR3 WDR18 ISG20L2 NOC4L RRP9 DGCR8 AARS2 EBNA1BP2 TSEN54 RRS1 NOB1 NOP2 NOP14 PES1 EXOSC5 PWP2 RRP1 RPUSD2 DHX37 DDX51 LAS1L CTU2 PELP1 SRRT SART1 URB1 MRTO4 KRI1 TRMT61A USB1 NHP2 GEMIN4 NSUN2 DDX27 TRMT12 TRMT44 NAT10 POP7 EXOSC6 NOP56 NVL DUS3L DDX54 INTS5 PIH1D1 IMP4 CPSF4 NPM3 TRMU PUS7 PUS1 UTP3 TRMT2B CDK5RAP1 TARBP1 ERCC2 NOLC1 NGDN TRMT112 CTU1 RPUSD4 ADAT1 PDCD11 FTSJ3 TSR1 ADAT3 RRP1B RPS2 RPS21 DROSHA MPHOSPH10 RPP25 ELAC2 RSL1D1 PARN METTL3 PA2G4 GAR1 TARBP2 GTPBP4 EXOSC10 METTL2B ANKRD16 RPL11 POP1 EXOSC2 METTL2A RNF113A NSUN4 METTL16 DDX49 RPL35 IMP3 HEATR1 RBFA SEPHS2 RRP7A DUS2 FBL TUT1 RPS15 RPS27 RPL27 TRMT6 RPL10A TSR2 INTS7 RPS16 PTCD1 RRP36 TFB2M NOP58 GRSF1 AGO2 WDR74 TRIT1 MRPS11 RPS28 YBEY EXOSC1 MDN1 NOL9 BYSL SMAD3 RTCB RPP38 UTP18 ERI3 RPL14 RPS14 NSUN5 HNRNPA2B1 ERI1 WDR3 KTI12 BOP1 UTP6 DCAF13 RRP15 INTS4 RPS24 URM1 LCMT2 ZNHIT6 RPL26 C9orf64 TRMT5 ESF1 RPS7 PUS3 RPL35A TP53RK RPS6 LYAR WDR12 FARS2 ZBTB8OS TRMT61B CPSF1 up
## FXR1_TARGET_GENES 0.0011236 0.0083666 0.5617872 3.035757 0 1002 SNRNP25 ZNF692 DNAJA3 ABCB9 HOOK2 EFNA4 ASPHD1 NOP9 PYGO2 INPPL1 C16orf91 RNF40 ZNF623 RER1 PUSL1 POLR3K NOL3 OGFOD3 ELMO3 SLC25A22 DDX56 PIGQ ATAD3B PRR7 SHARPIN ZBTB45 WDR55 METRN C1orf61 SLC50A1 KCNC3 WDR4 ZNF696 KIF16B PEX10 PIGO AIFM1 B4GALT7 MTX1 SRCAP CAPN15 JMJD4 MRPS26 NPLOC4 MVP RECQL4 SIPA1L3 RCC1 KCTD5 ZNF764 TSR3 USF1 TYSND1 KIAA1522 PFDN2 MFSD3 RHOT2 LRRC14 TSTD1 ZBTB42 DHCR7 NECAB3 CHD8 FKBP2 TRIP6 CHMP6 LSR SRM FAM50A TAF4 ZNF213 CCND1 FBRS AARS2 MAD1L1 ATXN2L ZC3H3 TSEN54 CAPN12 SNORA14B FRMD5 RPTOR DBNL NOP2 CYC1 TPRN PDAP1 ZNF462 HAGH ZGPAT MRPL12 SNAP47 TRAPPC9 DNAJC11 NELFA ZNF768 DDRGK1 FEM1A SEZ6L2 SEC24C SUMF2 PKMYT1 NADSYN1 ASB16 NOM1 ENTPD6 MRPL28 MPI MNT HAX1 CORO1B NUMA1 PPFIA3 DEAF1 SMURF1 STUB1 GNPTG AGK SRRT MFSD10 UBE2C ZNF3 ACADVL ANKZF1 LSM14B FAAH PGBD2 ALG1 PAQR4 UBTF SART1 CXorf56 KRTCAP3 GRWD1 F11R PPP1R37 ATXN7L3 HMBS CLDN7 SUSD4 CHCHD1 PCYT2 TRMT61A MLPH CYHR1 DAGLA TBX6 GEMIN4 TRABD SLC35B1 SESN2 EML2 AMH ARX BPNT1 EXOSC6 C1orf109 GRHL1 DHPS RREB1 TSFM ARFGAP1 PLEKHA8 AVIL UBE3C IRF7 TNPO2 TMEM201 DDX55 PHPT1 KMT2D CCNF C9orf163 HNRNPAB NMT1 CMTR1 IMPDH1 POLD1 PPP4C MRPL11 HMGXB3 FAHD1 EPN1 ERCC2 NOLC1 VPS4A XYLT2 CRTC2 ALDOA MUC1 ARFRP1 SIGIRR MRPL21 SLC35B2 ARID1A CD55 EIF3G TRMT112 RPUSD4 PPIL2 ADAT1 SNRPE KPTN B3GNT8 RABIF PPP6R1 PTOV1 DPH7 MSTO2P SSNA1 FTSJ3 LAMTOR1 UNC45A ABCA7 PHF12 PACS2 APEX1 GMEB2 ACIN1 LIF TIMM13 CLK3 PRDX5 ZMAT2 ZNF839 WDR73 TACO1 IGHMBP2 RNU5A-1 AMDHD2 LRIG3 SS18L1 RPL36 PNKP LSM5 NKAP LTBP3 CHMP2A DHRS1 SNAPC5 ZC3H4 HMGB3P22 PA2G4 PSMB4 SRRM5 DDIT3 PRKCA SNX19 B4GALT2 LINC00630 NAB2 MIS18A GTPBP4 METTL2B MFSD9 DPM2 FBXW5 IL17RC MAZ PLK1 PCED1A ANAPC2 FBXW9 TJP3 SYTL1 ZNF513 POMT2 CWC25 NEIL1 C1QBP PSMA7 TOR4A SYT7 TAF12 HSD11B1L PCK2 ATG9A TRNAU1AP GBA TAOK2 MPV17 KAZALD1 PTDSS2 SLX4IP RPL13 C8G CSRNP2 SLBP CYTH2 CIC DHRS13 TMEM147 WDR83 PSMC5 CASP2 SPRED2 RPL36AL SYMPK PAIP1 CORO2A NOL12 IARS2 ELL3 COG7 MAP3K11 THBS3 MORN1 PRDM15 VPS16 TRIM65 ANKRD54 AC007389.1 NOP14-AS1 USP19 HYI RBM28 ZNF579 RNASEH2A PAQR6 NDUFV3 CUL9 TOP3B TALDO1 POMZP3 RBM42 KLHDC2 FOXM1 SNRPC RRP7A SLC25A15 PLCH1 SGSM3 MLX AAR2 MRPL38 ANKRD13D C12orf10 POLR2A MRPL3 SLC1A5 MARVELD2 TCIRG1 RAI14 CREB3L4 CD151 NUP85 HDDC3 C1GALT1 HIRA CDK11A DMKN BCRP8 LZTR1 PTOV1-AS1 THAP3 RTN4RL2 LANCL2 CDYL RPS5 SPAG4 GTF3C5 CASP6 PPP1R13L DRG2 PAM INO80E EHMT1 TMEM182 TXN2 SAC3D1 TMEM179B SF3A3 CTSA TRIM47 TSPAN10 RRP36 NAGPA PIGM MAMSTR KANSL3 CALR MXD3 STRN4 MAF1 ZNF544 DTD1 ZFAND2B ZNF609 SCYL3 GSK3A MED29 PRKAR1B MRPS11 MORC2-AS1 PMF1 SAE1 STX6 ADCY9 RAB27A FAM131A NFIC SMG8 CNIH4 RPS29 NDUFC1 GTF2H2C DBP SMARCD2 HJURP MRPL10 TAF10 ZNF77 ALDOC CNIH2 DNAH2 XRRA1 ATP2A1 FKRP FAM193B CTNS GPI GTF2A2 DNMT3A PHLDB3 LRRC73 ZFAS1 SEC13 FAM200A DENND6B GLCCI1 ZNF653 SH3GL1 C8orf33 HUWE1 DPCD AP2A2 NSFL1C CASZ1 TOMM20 SLC4A11 MED26 MRPS27 ARFGEF2 FAM118B TULP4 IKBKE CDC6 TIGD6 POLR2J4 WDHD1 MIRLET7I XXYLT1 CRELD1 NUP210L RIN1 COMT CDR2 CYBA ZSWIM8 PLXNB1 AKAP8 VRK3 PMM1 ELK1 ARHGDIA IRGQ UNC119 UCK1 CDKN2AIPNL RRP15 CXorf38 UBC INTS4 SUSD2 PLS1 MLLT3 MTFR1L CITED1 POM121C NDUFA4 LARS2 SIX5 RPS7 SLC35E3 WDR81 CCAR2 PARP12 COX8A ACCS RALGDS RHOF PIP4K2B SLC35A3 TBC1D10A RBM23 OSGIN1 POLDIP3 UHMK1 SGMS1 GMPPB RPS6 RAE1 RTBDN SIPA1 UBL4A DBNDD2 up
## MORF_FBL 0.0015015 0.0083666 0.6767698 3.031263 0 129 TBL3 EIF3B UBE2I EIF3C TUFM HDGF NDUFV1 RNPS1 PPM1G JTB CYC1 PDAP1 CCT3 LSM4 AHCY LSM7 NCL SF3A2 RAD23A CBX3 FIBP HNRNPAB RUVBL2 PRMT1 SNRPA KXD1 EIF3I MRPL9 EIF3G SNRPE ILF3 CCT7 NONO NUDT1 TRIM28 PARK7 MCM7 RSL1D1 RALY IDH3B MCM2 CCT2 ILF2 DOCK3 C1QBP HSPD1 NDUFS3 HSP90AB1 DDOST HNRNPA1 BANF1 TMEM147 PSMB2 DDX49 HNRNPUL1 COA1 NME1 CS SNRPB FBL FUS IMPDH2 SNRPD2 RPL10A SSBP1 CLNS1A FAU UQCRH GPI RPL14 AURKB TOMM20 HNRNPA2B1 UBE2L3 POLR2I PUF60 XRCC6 BTF3 TARDBP PPP2R1A SUMO3 SRSF9 PCNA PSMD8 up
Clusters: 3 vs 1
fgsea_res <- fgsea_res_3v2
cond_nm <- 'Clusters: 3 vs 2'
fgsea_plot(fgsea_res$res_hm, pathways_title='Hallmark', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ----------------------------------- ---------- ---------- ----------- ---------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## HALLMARK_MYC_TARGETS_V2 0.0013158 0.0082237 0.5872727 2.202395 0 57 TBRG4 MRTO4 NIP7 SLC29A2 IPO4 MAP3K6 NOP2 NOC4L PES1 MYBBP1A AIMP2 DCTPP1 GRWD1 RRP9 PRMT3 TFB2M FARSA NOLC1 LAS1L NOP56 PUS1 PPRC1 SRM PLK1 UTP20 EXOSC5 HK2 TCOF1 MPHOSPH10 IMP4 PPAN PHB RRP12 CDK4 SUPV3L1 up
## HALLMARK_ESTROGEN_RESPONSE_EARLY 0.0011494 0.0082237 0.4764174 2.110862 0 191 DHRS3 NAV2 TFF1 TMPRSS3 ADCY9 THSD4 TTC39A SLC1A1 HR KAZN ADCY1 WWC1 AKAP1 FDFT1 TPBG LRIG1 SLC37A1 KCNK15 SLC7A5 DHRS2 ELF3 MYBBP1A FHL2 NADSYN1 PEX11A KRT8 TFAP2C ISG20L2 LAD1 RAPGEFL1 ASB13 ABAT TFF3 DHCR7 SVIL KLK10 NXT1 TJP3 ESRP2 WFS1 OVOL2 FRK PTGES SLC9A3R1 FOXC1 CELSR1 TPD52L1 P2RY2 SLC2A1 CELSR2 ABHD2 RHOD KCNK5 KRT19 TIPARP BHLHE40 DLC1 SLC19A2 NCOR2 MLPH RHOBTB3 TUBB2B CALCR TSKU FAM102A CANT1 HES1 TMEM164 MYOF TBC1D30 REEP1 PMAIP1 RPS6KA2 RARA RAB17 up
## HALLMARK_GLYCOLYSIS 0.0011403 0.0082237 0.4530466 2.008033 0 188 GALE ALDOB B3GALT6 SLC35A3 POLR3K CHST4 LHX9 LCT RBCK1 CYB5A TPBG MPI CTH PMM2 GNE GUSB ELF3 PKM AGL PAXIP1 BIK AGRN B3GNT3 ENO1 HS6ST2 CLDN9 GFPT1 TFF3 BPNT1 CHPF ALG1 GAL3ST1 EFNA3 TSTA3 B4GALT2 ANG SOX9 B3GAT1 EGFR CHST12 ADORA2B PRPS1 ARTN CLN6 ALDH7A1 SLC25A10 GALK2 HOMER1 CHPF2 PHKA2 SLC25A13 IDUA COG2 GMPPA MET XYLT2 QSOX1 ANGPTL4 SRD5A3 NASP HDLBP HK2 GOT2 B4GALT7 PPP2CB B3GAT3 PKP2 GLCE ANKZF1 PLOD1 TPST1 PYGB B4GALT1 PAM GPC3 HAX1 PSMC4 MIOX KDELR3 CHST6 SDC1 SLC37A4 P4HA1 ME2 PFKP DPYSL4 CD44 P4HA2 STC2 SDC3 IGFBP3 DDIT4 PPIA CHST2 B4GALT4 FAM162A up
## HALLMARK_DNA_REPAIR 0.0011834 0.0082237 0.4535629 1.938824 0 141 NME3 CMPK2 GTF2A2 POLD3 POLR1C ADRM1 GUK1 MPG TAF6 CCNO STX3 VPS37B APRT NME4 ITPA SNAPC5 NELFCD NT5C3A GMPR2 SMAD5 ELL SNAPC4 TAF10 TAF12 SF3A3 FEN1 UPF3B SSRP1 RAD52 DGCR8 DCTN4 GTF2F1 RPA3 POLR2C POLR2J DUT POLE4 TAF1C CANT1 DDB2 POLR2E GTF2H3 PCNA AGO4 POLA1 NPR2 DGUOK ZWINT NELFB RALA ALYREF POLR2F CDA EDF1 ERCC1 ERCC4 PNP TK2 LIG1 DDB1 BRF2 TYMS TP53 SUPT5H NT5C POLR1D POLD1 GTF3C5 POLH GTF2H5 REV3L POLA2 NUDT21 ERCC2 RRM2B SRSF6 TAF13 SEC61A1 POLR2A HPRT1 TSG101 NUDT9 POLR2H NME1 POLR2I UMPS GTF2H1 USP11 ADCY6 ERCC3 TARBP2 GPX4 IMPDH2 up
## HALLMARK_INTERFERON_ALPHA_RESPONSE 0.0012500 0.0082237 0.4619286 1.868512 0 93 ISG15 USP18 OASL CMPK2 HELZ2 TRIM5 RSAD2 MX1 HERC6 LY6E BST2 DDX60 OGFR IFI35 IFI27 TRAFD1 LGALS3BP RNF31 CMTR1 PNPT1 IFI44L NCOA7 PSMA3 MVB12A IL4R IFIT2 IFIT3 IFI44 MOV10 PARP12 PARP14 RTP4 OAS1 EIF2AK2 IFITM1 IRF7 TRIM21 PSME2 ADAR SAMD9 up
## HALLMARK_OXIDATIVE_PHOSPHORYLATION 0.0011547 0.0082237 0.4213379 1.852311 0 175 PDP1 MFN2 IDH3A CYB5A ETFA SDHB IDH3B ECI1 PDHA1 UQCRC2 MTRR SUCLG1 ACADSB OGDH RHOT2 AIFM1 NDUFS4 MRPS15 NDUFAB1 SLC25A5 SDHA GRPEL1 IMMT TIMM9 RETSAT NDUFB2 PHYH NDUFA4 NDUFS3 UQCR10 LRPPRC TOMM22 RHOT1 HSPA9 NDUFS6 DLST NDUFB7 MRPL11 TIMM8B FXN PDHX MRPS11 NDUFV1 NDUFC2 CYB5R3 VDAC1 NDUFA9 UQCRH TCIRG1 GOT2 POLR2F COX7A2L SLC25A4 BAX TIMM13 PMPCA TIMM10 COX8A ETFB MRPS30 COX4I1 UQCRQ NDUFS8 NDUFC1 ABCB7 CYC1 FDX1 NDUFA2 CS SUPV3L1 OXA1L NDUFS7 ATP6V1D COX7C MRPL34 TIMM50 CASP7 SLC25A11 COX5B IDH2 MTX2 ALAS1 NDUFB1 CPT1A MGST3 AFG3L2 ACADVL DLD up
## HALLMARK_MITOTIC_SPINDLE 0.0011377 0.0082237 0.4128065 1.837204 0 195 KIF1B STAU1 NUMA1 EPB41 TAOK2 CEP72 SHROOM2 OPHN1 MID1 CTTN TUBGCP5 KPTN CLIP1 RHOT2 BCAR1 GEMIN4 EZR ARFIP2 CDC42EP1 ABR WASL SPTAN1 CDC42BPA NET1 TUBGCP6 SPTBN1 BCR CEP250 ACTN4 PKD2 MYH10 KIF3B FGD6 RASAL2 KATNB1 KIF3C PAFAH1B1 LRPPRC PXN MARK4 ARL8A ALMS1 DLG1 MAP1S RABGAP1 TRIO MYH9 ARHGAP10 ARHGEF2 KIF22 MAP3K11 ARHGEF11 DYNC1H1 PLK1 AKAP13 TUBA4A MYO9B NCK2 CDC42EP4 DYNLL2 CSNK1D CLASP1 NF1 ARHGEF12 TSC1 PCNT FLNB ARHGAP27 ARF6 CYTH2 FARP1 MID1IP1 INCENP YWHAE PCM1 CD2AP CKAP5 up
## HALLMARK_MYC_TARGETS_V1 0.0011468 0.0082237 0.4044692 1.791223 0 189 GSPT1 PSMC6 EIF3B RNPS1 POLD2 SF3B3 TARDBP TUFM RPLP0 AIMP2 TFDP1 PSMD3 PSMB2 RPS5 CLNS1A NDUFAB1 RSL1D1 SNRPD3 SRSF1 RRP9 RPL22 RPS3 RPS2 PSMA7 IFRD1 RPL18 RUVBL2 EIF3D SRPK1 CUL1 RANBP1 NOLC1 TRIM28 PSMA6 NOP56 HDGF ETF1 CSTF2 FAM120A PPM1G DUT CTPS1 TXNL4A RPL34 SRM DHX15 SRSF7 PCNA SSBP1 GLO1 VDAC1 SF3A1 GOT2 XPOT MRPL23 PABPC4 UBE2L3 HSP90AB1 SNRPD2 SERBP1 PSMC4 HNRNPR PHB SNRPB2 YWHAE EEF1B2 TYMS CYC1 CCT5 CCT7 CDK4 SNRPA EIF3J RPL14 PPIA CCT3 PSMD1 RAD23B MCM7 PSMA1 C1QBP NHP2 HPRT1 ACP1 PA2G4 NOP16 STARD7 SNRPA1 NME1 APEX1 COX5A PSMD7 CCT2 HNRNPA2B1 LSM7 RAN ILF2 IMPDH2 SNRPG MCM2 PSMB3 FBL SRSF3 KPNB1 DDX21 XRCC6 up
## HALLMARK_PEROXISOME 0.0024510 0.0108225 0.4216844 1.731698 1 103 NR1I2 DHRS3 ALB PEX14 ABCB9 PEX11A LONP2 PRDX5 ABCD3 CRABP1 ACOT8 MVP HSD11B2 HRAS CTBP1 SLC35B2 RETSAT HMGCL GSTK1 DHCR24 CEL PEX13 SEMA3C CLN6 HSD3B7 SLC25A17 TSPO GNPAT DLG4 ISOC1 CTPS1 FIS1 ACSL5 SCP2 VPS4B SLC25A4 SERPINA6 CRAT ERCC1 SLC27A2 FDPS TTR MLYCD up
## HALLMARK_BILE_ACID_METABOLISM 0.0024390 0.0108225 0.3992939 1.651292 1 109 NR1I2 GC NR0B2 HSD17B6 ABCG8 NUDT12 SULT1B1 PEX11A LONP2 PRDX5 ABCD3 SLC27A5 PEX16 PEX7 SLC35B2 ABCA4 SLC22A18 BBOX1 FDXR RETSAT GSTK1 CYP8B1 DHCR24 PHYH PEX13 HSD3B7 PEX1 GNPAT ISOC1 ABCA2 PXMP2 AGXT BCAR3 ACSL5 CROT SCP2 CH25H NR3C2 LIPE SERPINA6 EFHC1 SLC27A2 PNPLA8 TTR MLYCD CYP46A1 OPTN up
## HALLMARK_CHOLESTEROL_HOMEOSTASIS 0.0025974 0.0108225 0.4245540 1.643079 1 69 ACSS2 FDFT1 SC5D CYP51A1 TRIB3 GUSB MVD TNFRSF12A LDLR DHCR7 SREBF2 TM7SF2 ATXN2 PCYT2 CHKA MAL2 MVK ABCA2 LGALS3 ALCAM ALDOC HMGCS1 SQLE up
## HALLMARK_ESTROGEN_RESPONSE_LATE 0.0022805 0.0108225 0.3675617 1.633051 1 193 GALE TFF1 TMPRSS3 HR SCUBE2 GPER1 FDFT1 TPBG SLC7A5 METTL3 ST14 DHRS2 AGR2 LSR CDH1 TFAP2C RAPGEFL1 ASCL1 TFF3 DHCR7 PRLR DLG5 HOMER2 CA2 KLK10 NXT1 TSTA3 TJP3 WFS1 OVOL2 ASS1 FRK PTGES PLAC1 SLC9A3R1 FOXC1 SLC2A8 TPD52L1 XRCC3 PKP3 CELSR2 ABHD2 KCNK5 KRT19 MAPK13 PERP NCOR2 CKB CALCR TSPAN13 FAM102A STIL MYOF HMGCS2 BTG3 up
## HALLMARK_IL6_JAK_STAT3_SIGNALING 0.0047393 0.0181984 -0.4117644 -1.881138 0 82 CSF3R ITGB3 CXCL13 CSF2RB IL1B A2M CCR1 ITGA4 PF4 IL2RG EBI3 CXCL9 CXCL10 CD36 HMOX1 IFNGR1 PLA2G2A LTB CXCL11 PIK3R5 ACVRL1 CD14 IL12RB1 IL18R1 CSF2 TLR2 IL2RA TNF CBL GRB2 PTPN2 STAT1 down
## HALLMARK_PROTEIN_SECRETION 0.0050955 0.0181984 0.4151293 1.666919 3 89 RER1 KIF1B ICA1 AP2B1 TSPAN8 GNAS SH3GL2 ARFGEF2 OCRL EGFR STX12 SGMS1 CLTA TMX1 ARF1 TOM1L1 COPB1 RAB22A YKT6 ARFGAP3 VAMP3 CAV2 RPS6KA3 GOLGA4 ERGIC3 NAPA RAB9A COG2 VPS4B ATP1A1 AP1G1 KRT18 PAM up
## HALLMARK_G2M_CHECKPOINT 0.0057274 0.0190913 0.3473882 1.537292 4 187 SLC12A2 GSPT1 E2F4 SMAD3 MNAT1 NUMA1 HMGA1 CHMP1A ARID4A LIG3 SLC7A5 PML TLE3 HUS1 TFDP1 ODF2 SRSF1 DMD HOXC10 TNPO2 CTCF POLE CUL1 RASAL2 PRMT5 NOLC1 ILF3 PAFAH1B1 TACC3 FANCC KIF22 MEIS2 NUP98 NCL ORC5 STIL PLK1 NUP50 CBX1 SQLE NASP CHAF1A DDX39A EGF E2F1 PURA CCNF SFPQ GINS2 BCL3 MCM3 UPF1 INCENP HIRA RAD54L CDK4 CHEK1 UBE2S RBM14 MARCKS CCND1 SRSF10 POLA2 HIF1A RAD23B TOP1 EFNA5 ABL1 KIF23 AMD1 CCNT1 MAPK14 CUL4A DTYMK KIF5B up
## HALLMARK_ALLOGRAFT_REJECTION 0.0077519 0.0200000 -0.5231831 -2.802208 0 187 LY86 IGSF6 CCL19 TLR1 GPR65 CCL4 C2 KLRD1 SRGN IRF8 FCGR2B GZMB CD8A MBL2 CXCL13 PTPRC CD86 TLR6 IFNG GZMA LCP2 CD8B IL1B CCR2 FGR CFP IL15 CD3G CD1D CD4 PRKCB CCR1 SIT1 CCR5 PF4 ETS1 IL2RG CD3D IL16 CD3E IL18RAP CCL22 CD28 CXCL9 CRTAM CTSS NLRP3 IL2 CD96 FASLG IFNGR1 ITGAL TRAT1 PRF1 CD2 STAB1 HCLS1 LTB CCND2 CD74 CCL13 CD247 IL10 GBP2 IL12RB1 RIPK2 CD40LG ITK IL18 CAPG CD80 IRF4 TLR2 HLA-G ELANE TIMP1 SPI1 LY75 F2R IL2RA CXCR3 TNF ITGB2 HLA-E STAT4 down
## HALLMARK_INFLAMMATORY_RESPONSE 0.0080000 0.0200000 -0.3785138 -2.037347 0 193 CSF3R TLR1 CD48 CYBB GPR183 LTA CMKLR1 RGS1 ITGB3 CD69 C3AR1 LCP2 OLR1 CCRL2 IL1B FPR1 SELL SELE IL15 SLC7A2 SLC31A2 ABCA1 PTAFR LPAR1 CCR7 IL18RAP EBI3 CCL22 IL7R CXCL9 P2RX7 CSF3 SLAMF1 NLRP3 C5AR1 PDE4B MSR1 CXCL10 CALCRL STAB1 CXCL11 IL10RA PIK3R5 ATP2B1 CD14 IL10 RIPK2 EMP3 GP1BA IL18R1 PTGER4 BEST1 TACR1 IL18 PLAUR NOD2 TLR2 IL1A MARCO CXCR6 TIMP1 CD70 HBEGF down
## HALLMARK_COMPLEMENT 0.0080000 0.0200000 -0.3152619 -1.696894 0 193 CR1 CR2 PLEK C2 FCER1G GZMK GZMB LTF GZMA LCP2 OLR1 GNB4 C9 LIPA SERPINA1 FCN1 CASP3 KYNU C1QA PLA2G7 GNG2 C1QC MMP8 GNGT2 DUSP5 SH2B3 CTSS ITGAM S100A9 CD36 GNAI2 PRCP CASP1 DOCK10 CASP5 PIK3R5 S100A12 CTSC CD40LG MMP12 GP1BA IRF2 CTSD PIK3CG CTSB SCG3 C3 PLAUR CFB ANXA5 TIMP1 PFN1 TMPRSS6 RHOG GCA C1R PIK3CA GRB2 APOC1 down
## HALLMARK_KRAS_SIGNALING_UP 0.0077519 0.0200000 -0.3129419 -1.676870 0 190 LCP1 TLR8 HSD11B1 IL33 F13A1 CLEC4A CMKLR1 IRF8 FCER1G C3AR1 ADAMDEC1 EPB41L3 LAPTM5 CD37 IL1B PDCD1LG2 PECAM1 LY96 MMP10 CXCR4 ETS1 PRKG2 IL2RG DOCK2 TMEM176A TMEM176B GYPC IL7R CTSS MAFB CXCL10 SERPINA3 ST6GAL1 CDADC1 FLT4 GLRX ACE IKZF1 RELN TSPAN7 CCND2 IL10RA RETN SPP1 CPE PRDM1 ARG1 SNAP25 GPNMB AKAP12 CSF2 SCG3 PLAUR CFB TRAF1 BIRC3 ID2 HBEGF ENG CBL ITGB2 GABRA3 SPARCL1 down
## HALLMARK_UV_RESPONSE_DN 0.0072029 0.0200000 0.3629953 1.543354 5 136 CDK13 MAGI2 SMAD3 PRKCE CDON ANXA4 ICA1 SYNJ2 PEX14 DDAH1 FHL2 LDLR SRI RBPMS IRS1 CDC42BPA PIK3R3 ANXA2 PRDM2 ABCC1 SLC22A18 COL11A1 MGLL ADORA2B MT1E DBP MIOS BHLHE40 DLC1 TJP1 DLG1 ERBB2 PRKCA MET BCKDHB SYNE1 EFEMP1 SMAD7 BMPR1A MAP2K5 TGFBR2 NR1D2 PRKAR2B SIPA1L1 COL1A1 NEK7 MGMT COL3A1 COL1A2 COL5A2 DYRK1A ATRN INPP4B SCHIP1 ATP2B4 up
## HALLMARK_HEDGEHOG_SIGNALING 0.0084626 0.0201491 0.4917349 1.645859 5 34 SHH OPHN1 PML TLE3 HEY1 CELSR1 SLIT1 AMOT ACHE MYH9 LDB1 PTCH1 NF1 TLE1 UNC5C up
## HALLMARK_E2F_TARGETS 0.0103448 0.0235110 0.3307955 1.465655 8 191 GSPT1 TBRG4 POLD3 CCP110 HMGA1 WDR90 POLD2 PMS2 RAD50 CHEK2 HUS1 DCTPP1 TIPIN AK2 DNMT1 PPP1R8 SRSF1 WEE1 TUBG1 CDKN2A SNRPB CTCF POLE RANBP1 PRPS1 PHF5A NUP205 SSRP1 NOLC1 ILF3 TACC3 NOP56 RPA3 PAN2 KIF22 DUT POLE4 CTPS1 POP7 PRKDC E2F8 PLK1 PCNA NASP SLBP DDX39A ATAD2 LYAR MCM3 PSMC3IP NUP153 LIG1 CSE1L up
## HALLMARK_UNFOLDED_PROTEIN_RESPONSE 0.0122549 0.0266411 0.3717789 1.526755 9 103 EDC4 IFIT1 ZBTB17 EXOSC10 SLC7A5 ARFGAP1 ATP6V0D1 GEMIN4 NOP14 TUBB2A WFS1 RRP9 NOLC1 SLC30A5 CHAC1 RPS14 IMP3 NOP56 HSPA9 PARN SHC1 PAIP1 NFYA CXXC1 FUS KHSRP EXOSC5 EXOSC2 LSM4 EIF4G1 ASNS DCTN1 XPOT CNOT4 EEF2 DDX10 ATF4 YIF1A EIF4EBP1 KDELR3 SRPRB SERP1 STC2 DDIT4 PSAT1 ERN1 BANF1 SEC11A KIF5B NHP2 CEBPG up
## HALLMARK_UV_RESPONSE_UP 0.0141343 0.0294464 0.3371143 1.449834 11 147 CYB5B COL2A1 NPTXR GLS CLTB MARK2 LHX2 CDC34 TCHH WIZ IGFBP2 TYRO3 CA2 BAK1 KCNH2 CLCN2 GRPEL1 EPCAM PSMC3 PARP2 FEN1 CDC5L CHKA SPR MAPK8IP2 YKT6 STK25 NAT1 FGF18 STIP1 BSG DLG4 SQSTM1 TUBA4A ONECUT1 BTG3 TGFBRAP1 MSX1 SULT1A1 ASNS PDAP1 RAB27A SIGMAR1 MRPL23 SLC25A4 STARD3 AGO2 UROD TST CDKN2B C4BPB CYB5R1 ICAM1 SHOX2 DGAT1 PTPRD RRAD up
## HALLMARK_INTERFERON_GAMMA_RESPONSE 0.0182232 0.0364465 0.3117589 1.386797 15 194 ISG15 USP18 OASL IFIT1 CMPK2 HELZ2 RSAD2 RBCK1 XAF1 MX1 HERC6 LY6E OAS3 ZNFX1 BST2 DDX60 OGFR PML TOR1B IFI35 IFI27 TRAFD1 LGALS3BP MX2 RNF31 CMTR1 AUTS2 PSMB2 PNPT1 IFI44L SRI MVP SECTM1 PSMA3 IL4R IFIT2 IFIT3 IFI44 PTGS2 DDX58 OAS2 NUP93 NAMPT PARP12 PARP14 RTP4 LYSMD2 PSMB10 ISOC1 EIF2AK2 RNF213 IFNAR2 TNFSF10 IRF7 TRIM21 PSME2 VAMP8 ADAR up
## HALLMARK_APICAL_JUNCTION 0.0229358 0.0424737 0.3102675 1.374043 19 189 CLDN11 CNTN1 TAOK2 LIMA1 SHROOM2 INPPL1 SRC LDLRAP1 MVD PDZD3 CDH1 AMH ADAM15 CLDN9 PLCG1 WASL ADRA1B CLDN6 PKD1 CDH4 IRS1 HRAS KCNH2 PIK3R3 TUBG1 EGFR HADH ACTN4 CTNND1 CLDN18 MYH10 CDH3 WNK4 MAPK13 TJP1 MADCAM1 TMEM8B GTF2F1 DLG1 SORBS3 MYH9 THBS3 SHC1 STX4 SPEG PTK2 CLDN8 CRB3 MAPK11 NRXN2 EXOC4 NLGN2 ITGA2 PCDH1 ADAM9 NF2 MDK NF1 MAP4K2 B4GALT1 CRAT ITGA9 TSC1 ICAM5 MPZL1 JUP GRB7 AMIGO2 ICAM1 AKT2 PARVA up
## HALLMARK_COAGULATION 0.0222222 0.0424737 -0.2645553 -1.320902 3 127 FGA FGG PLEK C2 ITGB3 MBL2 THBD OLR1 C9 SERPINA1 PECAM1 A2M C1QA MMP10 PF4 P2RY1 MMP8 APOC2 down
fgsea_plot(fgsea_res$res_c1, pathways_title='C1 positional genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------- ---------- ---------- ---------- --------- ------------- ----- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## chr1p36 0.0010582 0.0122037 0.6120852 2.889960 0 395 SNORA59A DHRS3 GALE RERE FBXO42 VPS13D SSU72 RNF207 SPEN KLHDC7A TRNP1 RNU6ATAC18P CEP104 UBR4 ISG15 NR0B2 DNAJC16 DNAJC11 SLC9A1 NOC2L ARHGEF16 ATAD3B IL22RA1 UBE4B ATAD3A NPHP4 PEX10 DVL1 ATP13A2 MRPL20 ATAD3C AURKAIP1 C1orf174 DDI2 RER1 CASZ1 SMIM1 AKR7A2 SRRM1 MFN2 B3GALT6 AKR7A3 PER3 PUSL1 PLEKHN1 CDK11B EIF4G3 WRAP73 PHF13 PANK4 KAZN KIF1B MTOR UBE2J2 NBPF3 FBXO44 VWA1 DHDDS NADK LYPLA2 GPN2 CROCCP3 ZBTB48 SLC25A33 PGAM1P11 ZBTB17 LRRC47 MRTO4 TMEM201 TMEM222 MTFR1L ICMT TMCO4 RCC2 ARHGEF10L PRDM16 EXOSC10 CDK11A CCNL2 RN7SL574P TPRG1L SDF4 RNF223 CLCNKB AKR7L MAP3K6 C1orf159 HES5 NIPAL3 FBXO2 MIR34A HES4 ARHGEF19 SDHB MMP23A RHCE TARDBP STPG1 TMEM51-AS1 EMC1 KIAA2013 MIR429 PINK1-AS MIIP LDLRAP1 RNU6-1265P CD164L2 PEX14 LINC00337 CLSTN1 PAFAH2 MYOM3 TP73-AS1 MIB2 EPHA2 MORN1 GRHL3 LINC00115 SZRD1 AGRN LINC00339 ARID1A UBXN10 GPR157 NOL9 OTUD3 ENO1 CROCCP2 CNKSR1 MST1P2 UBIAD1 SKI RPS6KA1 ASAP3 FAM87B PARK7 MUL1 TNFRSF25 DFFA PDIK1L NUDC ESPNP TMEM82 CEP85 KLHL17 DDOST NPPA CTNNBIP1 AGTRAP KDM1A SCNN1D MAD2L2 PRDM2 RPL22 ACAP3 WDTC1 MEGF6 ALDH4A1 CALML6 PLEKHG5 MT1XP1 CLCNKA FAM131C IFNLR1 TBCAP2 THAP3 TP73 HMGCL FUCA1 MTND2P28 PLEKHM2 MIR200A MXRA8 TTLL10-AS1 CLCN6 TCEA3 OSTCP2 NBPF1 PINK1 NMNAT1 PITHD1 GNB1 SLC35E2B ANKRD65 NBPF2P CAMK2N1 CROCC VAMP3 MAN1C1 SAMD11 NCMAP RN7SKP269 EPHB2 TMEM51 TMEM52 MMEL1 RPL11 PAQR7 RNU1-3 DRAXIN TMEM88B USP48 UBXN11 GPR3 up
## chr16p13 0.0011025 0.0122037 0.6248261 2.862847 0 272 PRSS33 PDXDC1 PRSS41 ZG16B PRSS22 ADCY9 C16orf91 GLYR1 GSPT1 JMJD8 DNAJA3 UBN1 HMOX2 CARHSP1 TRAF7 PGP SOX8 RAB11FIP3 NME3 PAQR4 E4F1 SNRNP25 MPV17L METRN TBL3 HS3ST6 POLR3K WDR24 RNPS1 C1QTNF8 TELO2 PDPK1 SRRM2 FLYWCH2 RHBDF1 CLEC16A PRSS27 AXIN1 MLST8 MRPS34 ZC3H7A NOMO1 WDR90 CCDC78 NTHL1 GFER PPL RPUSD1 ZNF174 NMRAL1 UBE2I PMM2 CLUAP1 IFT140 KREMEN2 ZNF598 NPRL3 MPG CCDC154 SMIM22 COX6CP1 C16orf90 MGRN1 MIR3180-4 NPIPP1 STUB1 CAPN15 ECI1 ANKS3 DECR2 NPIPA3 CREBBP TNFRSF12A SLX4 SSTR5 NAA60 BRICD5 RRN3 TSR3 PDIA2 EME2 NTN3 METTL22 LUC7L HAGH TBC1D24 MTRNR2L4 TSC2 NDUFB10 PIGQ NUBP2 ZNF597 LMF1 RHOT2 MAPK8IP3 KCTD5 GLIS2 USP7 CLDN9 ABAT CHTF18 NME4 OR1F1 ALG1 PKD1P6 THOC6 WFIKKN1 SLC9A3R2 CLDN6 NUDT16L1 ZSCAN32 PKD1 RSL1D1 GNPTG ZNF205 HAGHL MIR4718 DNASE1L2 RAB40C ABCC1 ZNF263 TMEM186 MRPL28 C16orf72 ERVK13-1 SNHG9 RPS2 ZNF500 SNORD60 RMI2 NPIPA1 DNASE1 CLCN7 ZNF213 GRIN2A FAHD1 RGS11 RHBDL1 IGFALS IL9RP3 NOMO3 MIR5587 FBXL16 PARN WASH4P MIR1972-1 MIR3180-1 TEKT5 FOPNL up
## chr16q22 0.0012240 0.0122037 0.6191996 2.630947 0 132 ACD CYB5B E2F4 DYNC1LI2 EDC4 CES3 NOB1 CHST4 PARD6A SLC7A6 MARVELD3 WWP2 C16orf70 NFAT5 CES2 DDX19A SMPD3 NIP7 NUTF2 RANBP10 VPS4A SF3B3 COG4 EXOSC6 CENPT SLC7A6OS LCAT SLC9A5 CDH1 PSKH1 HAS3 CMTM4 NAE1 ATP6V0D1 DDX19B SNTB2 FTLP14 TRADD PDXDC2P ENKD1 PRMT7 TERF2 HSD11B2 KIAA0895L DHX38 ESRP2 HYDIN FBXL8 THAP11 PDF RN7SL279P HSF4 VAC14 MIR1972-2 ZFHX3 SLC12A4 ZDHHC1 CTCF PDP2 CDH3 GFOD2 FHOD1 CBFB TMEM208 ELMO3 PSMB10 RNU6-1262P CES4A ATXN1L TANGO6 B3GNT9 KCTD19 CMTR2 up
## chr7p22 0.0012771 0.0122037 0.6449290 2.582430 0 85 SUN1 ADAP1 GET4 ZNF12 ZDHHC4 IQCE EIF3B PMS2CL GPER1 MAD1L1 PMS2 FBXL18 TMEM184A EIF2AK1 TNRC18 WIPI2 USP42 INTS1 AIMP2 C1GALT1 PSMG3 KDELR2 RBAK RNF216P1 FAM220A RNF216 RAC1 SNX8 BRAT1 CARD11 CHST12 ZNF316 DAGLB AP5Z1 COX19 MIR589 SLC29A4 ZNF890P C7orf50 CCZ1B PRKAR1B MICALL2 CYTH3 C7orf26 FOXK1 UNC93B2 FAM20C AMZ1 OR7E136P ANKRD61 NUDT1 GPR146 ALG1L5P PDGFA up
## chr1p35 0.0012453 0.0122037 0.6019850 2.470546 0 99 SRSF4 OPRD1 PHACTR4 TRNAU1AP IFI6 MECR TMEM234 SESN2 BSDC1 YTHDF2 KIAA1522 SNORA73B TXLNA EPB41 PEF1 FAM76A SNHG12 RCC1 ZNF362 HDAC1 PTPRU FNDC5 AHDC1 KPNA6 TMEM54 EIF3I PUM1 SNHG3 HPCA SERINC2 EYA3 ZBTB8A SCARNA1 IQCC SYNC TRIM62 AK2 PPP1R8 TMEM200B TAF12 STX12 S100PBP MARCKSL1 SPOCD1 KHDRBS1 ZSCAN20 SNRNP40 TSSK3 SNORA44 MIR5585 ZBTB8OS RBBP4 HMGB4 RN7SL559P DNAJC8 ZCCHC17 MED18 ZBTB8B HSPD1P14 up
## chr1p34 0.0011561 0.0122037 0.5404199 2.399365 0 192 KIAA0319L MUTYH THRAP3 INPP5B ZSWIM5 SCMH1 ZMYM4 TRAPPC3 CITED4 GNL2 NCDN TMEM53 C1orf122 ADPRHL2 POMGNT1 STK40 ERI3 ZMYND12 FOXO6 TRIT1 MEAF6 MAP7D1 RIMKLA RHBDL2 OSTCP5 IPP PTPRF RPL5P4 RN7SL503P GPBP1L1 DPH2 ZMPSTE24 COL9A2 ELOVL1 MRPS15 PSMB2 AKIRIN1 GUCA2A GJA9 EIF2B3 MTF1 RLF MAST2 B4GALT2 PIK3R3 RNU6-1237P SNIP1 RNA5SP44 RNU6-584P DNALI1 OSCP1 TEKT2 ZC3H12A MANEAL NFYC HECTD3 SF3A3 IPO13 C1orf216 CCDC24 SLC2A1 PPIE KDM4A YRDC MACF1 MED8 SZT2 TSPAN1 COL8A2 HIVEP3 C1orf109 AGO3 ARTN ZMYM1 EXO5 EBNA1BP2 ERI3-IT1 HPCAL4 RNU6-608P FOXJ3 CTPS1 CLSPN RNF220 EPHA10 TMSB4XP1 PLK3 AGO1 RPS8 AGO4 SNORD46 TMEM125 NASP SLC2A1-AS1 C1orf210 PPCS ZNF684 ZMYM4-AS1 SNORA55 up
## chr15q15 0.0012315 0.0122037 0.5540612 2.300644 0 108 MAPKBP1 TP53BP1 RPAP1 PLA2G4B MGA INO80 EHD4 ACTBP7 DNAJC17 C15orf56 SPTBN5 TUBGCP4 ZFYVE19 PIN4P1 FRMD5 LRRC57 TMEM62 RNU6-1169P CASC4 UBR1 RTF1 RPS3AP47 RPUSD2 TYRO3 RMDN3 GANC CDAN1 JMJD7 PPIP5K1 SPINT1 HNRNPMP1 GAPDHP55 TMEM87A VPS39 KRT8P50 PAK6 CHAC1 CKMT1A ZSCAN29 CKMT1B PPP1R14D LCMT2 PLA2G4D ISCA1P4 DISP2 CTDSPL2 RNU6-516P ZNF106 VPS18 CHST14 up
## chr7q22 0.0011848 0.0122037 0.5238812 2.272012 0 153 MUC17 CYP3A5 BAIAP2L1 KPNA7 SMURF1 NAPEPLD LRWD1 ZNF3 PUS7 PPP1R35 TAF6 CUX1 NYAP1 SLC26A5 SRRT UFSP1 AGFG2 NAT16 LRCH4 TRIP6 TRIM56 LARP1BP2 ZSCAN21 AP4M1 TRIM4 RN7SL8P AZGP1 ZKSCAN5 MIR4653 LHFPL3 MIR25 RN7SL750P ZNHIT1 ZKSCAN1 GNB2 STAG3L5P-PVRIG2P-PILRB GIGYF1 PLOD3 ARPC1A NAMPT TSC22D4 SPDYE6 AP1S1 MEPCE ZSCAN25 RN7SL549P POLR2J ALKBH4 RWDD4P1 ACHE SLC26A4 ARMC10 ORC5 TRRAP GPC2 EPHB4 ZNF394 FIS1 POP7 SYPL1 PCOLCE-AS1 KMT2E-AS1 PILRB SRPK2 PDAP1 VGF KMT2E POLR2J3 SLC12A9 FAM185A PRKAR2B RINT1 COPS6 ATXN7L1 FBXO24 CPSF4 BCAP29 C7orf61 SPDYE2B DNAJC2 PMPCB CBLL1 EFCAB10 MUC3A PMS2P1 MUC12 CRYZP1 S100A11P1 ZNF655 BUD31 SPDYE2 CLDN15 CDHR3 MOSPD3 CYP3A7 LAMTOR4 DUS4L PSMC2 OR2AE1 up
## chr16q24 0.0012484 0.0122037 0.5558417 2.251079 0 92 CTU2 GSE1 ZCCHC14 CHMP1A ZFPM1 SPATA33 IL17C SLC7A5 PIEZO1 ZDHHC7 MVD RPL13 ZC3H18 EMC8 AFG3L1P APRT TUBB8P7 FOXL1 USP10 GALNS SPATA2L ANKRD11 SPG7 CDT1 FBXO31 CDK10 CENPBD1 FAM157C SPIRE2 VPS9D1-AS1 FANCA TRAPPC2L GAS8 ZNF276 MTHFSD URAHP WFDC1 TAF1C KIAA0513 PRDM7 MIR5189 AC010536.1 DEF8 VPS9D1 ACSF3 KLHL36 LINC01081 HSDL1 MBTPS1 BANP CPNE7 up
## chr7q11 0.0012853 0.0122037 0.5519783 2.194227 0 81 TYW1 TMEM248 CRCP ASL STAG3L4 VKORC1L1 CCT6P3 RPL35P5 SKP1P1 PMS2P4 GTF2IRD2 PTPN12 ERV3-1 SBDS GUSB ZNF117 LINC00174 ZNF273 GTF2I AUTS2 DTX2 RSBN1L STAG3L3 DTX2P1 PMS2P5 PMS2P3 GTF2IRD2B GSAP ZNF107 SBDSP1 POMZP3 YWHAG FDPSP7 RABGEF1 NSUN5P1 KCTD7 ZP3 FAM185BP SNORA22 TPST1 CCDC146 FDPSP2 ZNF138 GTF2IP1 NSUN5 STAG3L2 PMS2P9 TMEM60 SPDYE9P up
## chr16p11 0.0012270 0.0122037 0.5196118 2.184860 0 120 TBX6 RNF40 ZNF629 KCTD13 TAOK2 ASPHD1 ZNF747 ZNF768 CD2BP2 FBXL19 SULT1A2 QPRT HERC2P4 MAPK3 TUFM KAT8 ZNF764 SETD1A NFATC2IP TBC1D10B SRCAP ATXN2L SEZ6L2 CTF1 BMS1P8 DCTPP1 PHKG2 PRSS8 SEPHS2 TMEM219 SLC6A10P MVP FBRS HERC2P5 ZNF646 BCKDK GDPD3 PRR14 PPP4C RABEP2 SLC7A5P1 SH2B1 EIF3C HSD3B7 YPEL3 CDIPT ZNF771 ZNF689 ZNF688 KIF22 CTF2P HIRIP3 FUS STX4 MAZ HERC2P8 ZNF668 ZNF48 C16orf58 SULT1A1 ZNF785 VKORC1 MIR3680-2 COX6A2 RNU6-1043P up
## chr15q23 0.0014124 0.0122037 0.6064926 2.144786 0 42 THSD4 AAGAB NOX5 THAP10 CT62 PKM TLE3 RNU2-65P NR2E3 MYO9A IQCH C15orf61 CALML4 RPLP1 IQCH-AS1 CLN6 SENP8 RNA5SP399 PAQR5 LARP6 SPESP1 FEM1B LRRC49 MAP2K5 GLCE ITGA11 MIR629 up
## chr7p13 0.0014430 0.0122037 0.6265419 2.140700 0 35 NPC1L1 NUDCD3 URGCP TBRG4 RASA4CP POLD2 SNORA5C UBE2D4 POLM OGDH LINC00957 SPDYE1 TMED4 BLVRA DBNL YKT6 SNORA5A DDX56 ZMIZ2 CAMK2B COA1 TUBG1P POLR2J4 AEBP1 up
## chr20q13 0.0011062 0.0122037 0.4634683 2.122356 0 265 NTSR1 HNF4A RIMS4 DIDO1 TAF4 MRGBP HELZ2 YTHDF1 STAU1 OSBPL2 CABLES2 PRPF6 ADRM1 UCKL1 ZNF334 SPATA2 TCFL5 SLC2A10 MIR941-2 GID8 KCNK15 PMEPA1 ZNF512B GNAS ZNFX1 SS18L1 SLC2A4RG OGFR LSM14B VAPB ARFGAP1 ZFP64 PCK1 LINC00659 ZGPAT RPS21 PARD6B KRT18P4 RN7SL197P RPS4XP3 SDC4 TFAP2C MTG2 ZSWIM1 SNX21 PPP4R1L TMEM189 MIR941-3 MATN4 TTPAL RBBP8NL DBNDD2 ARFGEF2 DNAJC5 ZNF663P ACOT8 MIR941-1 EEF1A2 COL20A1 ARFRP1 RTEL1 PIGT B4GALT5 NELFCD ZMYND8 TP53RK LAMA5 SLCO4A1 SEMG1 CDH4 SAMD10 EYA2 ATP9A DNTTIP1 KCNQ2 TOMM34 RNF114 PSMA7 GMEB2 DDX27 TPD52L2 ZSWIM3 RAB22A GNAS-AS1 GAPDHP54 RN7SKP184 PI3 SALL4 CHRNA4 FITM2 NPEPL1 TSHZ2 PABPC1L SLC9A8 ABHD16B RTEL1-TNFRSF6B ZFAS1 ZNF335 PCIF1 MKRN7P up
## chr16p12 0.0012392 0.0122037 0.5170609 2.112009 0 96 TMC5 HS3ST4 KIAA0556 GTF3C1 GDE1 CCP110 POLR3E EEF2K ZKSCAN2 COG7 SBK1 NOMO2 TNRC6A IQCK UQCRC2 TMEM159 SMG1 CDR2 CLEC19A NSMCE1 TMC7 EARS2 GSG1L LCMT1 XPO6 ERI2 NPIPB5 NDUFAB1 PALB2 RNU6-1340P IL4R UBFD1 NPIPB3 CRYM-AS1 SYT17 GP2 RN7SKP23 THUMPD1 KNOP1 EIF3CL CRYM COQ7 LYRM1 DNAH3 ANKS4B RPS15A PLK1 RRN3P1 USP31 up
## chr1p33 0.0014184 0.0122037 0.5946657 2.090085 0 40 FOXD2 FAAH LINC00853 FOXD2-AS1 LRRC41 AGBL4 SPATA6 EFCAB14 NSUN4 AGBL4-IT1 MTND2P29 CMPK1 CYP4A22-AS1 FOXE3 ZNF859P RNU6-723P PPP1R8P1 ATPAF1 STIL PDZK1IP1 BEND5 UQCRH CYP4X1 TEX38 up
## chr7q36 0.0012516 0.0122037 0.5087150 2.088473 0 101 ACTR3B ZNF282 SLC4A2 ZNF398 ZNF777 PTPRN2 NOM1 SHH UBE3C MNX1 LMBR1 PAXIP1-AS1 RNF32 SSPO WDR60 FASTK TMUB1 ESYT2 PAXIP1 ATP6V0E2-AS1 ZNF783 KMT2C CDK5 MNX1-AS1 ABCF2 REPIN1 AGAP3 ZNF786 KRBA1 ZNF746 GALNT11 KCNH2 ZNF212 ATP6V0E2 CUL1 ABCB8 RNU4-31P SMARCD3 LINC01006 ZNF862 LRRC61 PAXIP1-AS2 RBM33 MIR153-2 MNX1-AS2 CHPF2 ACTR3C RNY4 up
## chr20p12 0.0013477 0.0122037 0.5586240 2.087880 0 58 KIF16B FERMT1 LRRN4 RNA5SP475 BTBD3 CHGB SLX4IP CRLS1 FLRT3 RRBP1 MACROD2 DSTN PLCB1 ANKEF1 MACROD2-IT1 TASP1 SPTLC3 ESF1 RNU6-115P MACROD2-AS1 TRMT6 PA2G4P2 DYNLT3P1 RN7SL864P ENSAP1 RPS3P1 PCNA BFSP1 GPCPD1 GAPDHP2 ISM1 AIMP1P1 SNRPB2 RN7SKP69 TMEM230 MCM8 up
## chr11q13 0.0010953 0.0122037 0.4499068 2.071968 0 290 MIR194-2 AP001372.2 SNORD15B COA4 C2CD3 OTUB1 RNF121 AP000439.2 STARD10 BAD FADD PPFIA1 NUMA1 RNF169 POLD3 PLCB3 CATSPER1 LIPT2 SHANK2 ZNHIT2 CTTN SLC29A2 DGAT2 RCOR2 MARK2 INPPL1 IGHMBP2 PPME1 PGM2L1 CST6 OR7E128P CAPN1 CCDC87 NUDT22 TRPT1 GPHA2 LRP5 NADSYN1 KLHL35 CLPB GDPD5 MACROD1 PRDX5 MRPL49 LRTOMT DNAJC4 MRPL48 DHCR7 FAM86C1 LAMTOR1 DPP3 GPR137 OVOL1 VPS51 RELA RPS6KA4 ENPP7P8 TM7SF2 OR7E126P SF1 RPS3 PPP1R14B MEN1 FAU HNRNPA1P40 ESRRA SART1 MUS81 ATG2A TMEM134 P2RY2 CHKA NAA40 FIBP XRRA1 SCYL1 ACY3 PPP2R5B RHOD KLC2 CCDC85B BRMS1 PAAF1 STIP1 TRMT112 TIGD3 NEAT1 EIF1AD DPF2 FRMD8 CCDC58P5 RIN1 CDC42BPG SF3B2 FOSL1 MRPL11 RANP3 DOC2GP TSKU PLEKHB1 MAP3K11 CNIH2 RBM14-RBM4 PELI3 NDUFV1 HMGN2P38 PITPNM1 LTBP3 PPP6R3 NRXN2 RCE1 IFITM9P up
## chr22q13 0.0011390 0.0122037 0.4586353 2.057733 0 215 NPTXR TTLL12 MCAT PACSIN2 GCAT FAM83F ZBED4 LRRC37A14P CACNA1I ANKRD54 GTPBP1 NCAPH2 SYCE3 ZC3H7B EP300 WNT7B SULT4A1 BIK LMF2 TRMU FAM227A CARD10 JOSD1 MAPK12 PLXNB2 XPNPEP3 CHKB CDC42EP1 MRPS18CP6 ADM2 SREBF2 PRR5-ARHGAP8 TOB2 TTC38 UPK3A PPP6R2 TEF RN7SKP80 CBY1 TRIOBP RPS19BP1 DNAL4 L3MBTL2 LINC00634 TUBGCP6 EIF3L CPT1B SBF1 TRABD PICK1 CDPF1 MICALL1 ATXN10 POLDIP3 CELSR1 EFCAB6 C22orf46 CBX6 RIBC2 PHF5A ODF3B LINC00899 SGSM3 RNU6-379P MAPK8IP2 CHADL BRD1 TMEM184B RANGAP1 SLC25A17 TOMM22 RRP7A ARFGAP3 PDXP TSPO MIR3619 RPL3 CSNK1E APOBEC3B ALG12 DENND6B TCF20 MAFF CYB5R3 NUP50 GGA1 BAIAP2L2 MAPK11 PHF21B PPARA ARHGAP8 ELFN2 TBC1D22A PNPLA3 POLR2F SNORD83A PKDREJ SCUBE1 A4GALT MIOX ARSA TYMP ATF4 GRAMD4 DMC1 PIM3 KDELR3 TAB1 RNU6-375P RPL5P35 ADSL CHKB-CPT1B RNU6-495P SCO2 APOBEC3A SLC25A5P1 up
## chr5p15 0.0013055 0.0122037 0.5074364 1.984649 0 71 SLC9A3 SLC6A3 MYO10 ZDHHC11 LINC01019 TPPP ZDHHC11B CEP72 SLC6A19 PLEKHG4B MTRR SPCS2P3 RN7SKP79 NSUN2 EXOC3 BRD9 SDHA CLPTM1L CCDC127 DNAH5 NDUFS6 EEF1A1P13 TRIO SLC12A7 DAP FBXL7 PDCD6 RPL30P7 ROPN1L LPCAT1 DCAF13P2 up
## chr11p11 0.0013298 0.0122037 0.5061100 1.941524 0 66 AMBRA1 ZNF408 FNBP4 PACSIN3 MAPK8IP1 CRY2 ARHGAP1 NUP160 PEX16 TRIM53CP SYT13 SNORD67 TRIM51GP MADD PSMC3 CREB3L1 CELF1 MYBPC3 NDUFS3 ARFGAP2 C11orf49 HSD17B12 TP53I11 DDB2 SEC14L1P1 NR1H3 DGKZ AGBL2 PTPMT1 MDK CHRM4 RN7SL652P SLC35C1 CKAP5 HARBI1 MTCH2 ALKBH3 ATG13 AC068858.1 up
## chr19p13 0.0010246 0.0122037 0.3960020 1.900187 0 544 ONECUT3 GIPC1 RFX2 UCA1 GDF15 FZR1 SMARCA4 FEM1A SH2D3A LRRC8E STAP2 CCDC130 MEX3D CYP4F12 NR2F6 SLC35E1 BST2 MLLT1 CDC34 CDC37 CHERP ZNF440 LRG1 TRIP10 EVI5L BTBD2 REXO1 CILP2 AMH GTPBP3 ODF3L2 PTBP1 CSNK1G2 ADAMTSL5 AP3D1 TIMM44 CCDC159 EEF1DP1 TICAM1 SF3A2 ZFR2 B3GNT3 GNA11 TMEM259 LDLR WIZ STK11 PIAS4 CYP4F23P XAB2 EPS15L1 EFNA2 THOP1 SLC5A5 FBXL12 DHPS TRMT1 DNMT1 KRI1 MVB12A SCAMP4 DUS3L TJP3 INSL3 BRD4 MIR3189 ZBTB7A AKAP8L TMEM161A ZNF823 HOOK2 ELL ALKBH7 C19orf71 C19orf44 KXD1 CACTIN LONP1 CELF5 PCSK4 MIER2 RPL18A TNPO2 MIDN MAP2K7 PBX4 AP1M2 MAP2K2 TGFBR3L CC2D1A SBNO2 NACC1 AKAP8 RPL36 RPS28 WDR18 ZNF560 FARSA POLRMT YIPF2 GATAD2A KLF16 ILF3 DDX49 TMEM38A CERS4 PDE4C ANKRD24 MED26 SIN3B CAMSAP3 DOT1L MPND DCAF15 CD320 RFXANK FBXW9 RAB11B GRIN3B DNM2 RNF126 MADCAM1 SLC27A1 BSG ARMC6 DAPK3 REEP6 PLEKHJ1 ELAVL1 GTF2F1 RFX1 MKNK2 SNORD105B NR2C2AP HMG20B MAP1S ATP13A1 RPS15 ZNF317 FUT3 C19orf67 MRPL54 ADAT3 ZNF563 NDUFB7 GPR108 PIP5K1C CPAMD8 ILVBL MED16 ELOF1 GADD45GIP1 RN7SL192P ZNF562 ZNF443 LPAR2 SNAPC2 USE1 EIF3G ECSIT POLR2E RAD23A SGTA SUGP2 KHSRP DOHH CCDC151 R3HDM4 ZSWIM4 MYO9B LMNB2 CCDC124 CRB3 ANGPTL4 HAUS8 ANO8 WDR83 ABCA7 SPPL2B SSBP4 LSM4 NFIX CHAF1A MISP DDX39A ARHGEF18 TM6SF2 SH3GL1 SIRT6 DDA1 UBXN6 ATG4D RAVER1 C19orf57 STX10 TPGS1 UBA52 NDUFA13 DPP9 NWD1 BABAM1 DAZAP1 JUND SAFB2 SLC39A3 PRR22 RTBDN PPAN EEF2 TIMM13 RAB11B-AS1 PDE4A ICAM5 MRPL4 C19orf53 TSSK6 TMEM205 KLHL26 PRKCSH UPF1 TLE2 CTXN1 SYDE1 TMEM221 GCDH MPV17L2 PIN1 GNA15 MFSD12 RNU6-9 up
## chr15q24 0.0012987 0.0122037 0.4813066 1.892120 0 74 TSPAN3 EDC3 MPI SIN3A CLK3 ETFA FBXO22 LMAN1L TYRO3P NEO1 PML SCAMP2 RPP25 MIR3713 NEIL1 SCAPER RPL36AP45 COMMD4 MAN2C1 IMP3 FAM219B RN7SKP217 DNM1P35 STOML1 PTPN9 LOXL1 ISL2 LOXL1-AS1 NRG4 HIGD2B STRA6 BBS4 HMG20A up
## chr20p13 0.0012837 0.0122037 0.4730676 1.888690 0 83 SLC52A3 PTPRA CENPB RBCK1 DDRGK1 TRIB3 TBC1D20 IDH3B FASTKD5 STK35 ZCCHC3 PANK2 MAVS ACTG1P3 ITPA UBOX5 RNF24 NRSN2 LZTS3 C20orf96 SNRPB NSFL1C UBOX5-AS1 SPEF1 MRPS26 FAM110A NOP56 PCED1A SMOX SOX12 ZNF343 EBF4 VPS16 C20orf27 CSNK2A1 AP5S1 SNPH PSMF1 up
## chr15q22 0.0012821 0.0122037 0.4653003 1.854457 0 82 SMAD3 SLTM ZNF609 GCNT3 TRIP4 GTF2A2 MEGF11 TLN2 MTFMT FAM81A PIGHP1 DAPK2 CLPX SNX1 VPS13C SNAPC5 TIPIN FOXB1 ANXA2 MAP2K1 SMAD6 DIS3L C2CD4A RNF111 RAB11A CSNK1G1 RPS3AP6 ZNF444P1 SPG21 C2CD4B UBAP1L FBXL22 USP3 RPL4 up
## chr14q12 0.0013228 0.0122037 0.4770865 1.821831 0 65 NOP9 AKAP6 REC8 IPO4 FOXG1 RN7SL660P NFATC4 RNF31 NUBPL GMPR2 NYNRIN TM9SF1 STRN3 EMC9 LTB4R RIPK3 HECTD1 KHNYN RABGGTA DHRS1 NRL PSME2 RNU6-602P HIGD1AP17 MIR624 COCH RPL26P3 SDR39U1 ARHGAP5-AS1 DCAF11 CBLN3 AP4S1 MIR4307 RNU6-541P up
## chr4p16 0.0012255 0.0122037 0.4305147 1.804768 0 118 STK32B STX18 RN7SKP275 RNF212 LETM1 NOP14 SCARNA22 DOK7 TNIP2 NOP14-AS1 WFS1 NELFA CTBP1 GRPEL1 ZFYVE28 RNF4 CPLX1 GAK FAM193A AFAP1-AS1 MAEA TACC3 TADA2B BLOC1S4 PIGG TMED11P MRFAP1 TMEM175 TRMT44 MFSD10 FGFRL1 MRFAP1L1 MIR548I2 PCGF3 FAM53A AC097381.1 C4orf48 IDUA ZNF518B UVSSA MSX1 EVC RN7SL589P ALG1L7P SPON2 SLBP ALG1L3P LYAR UNC93B7 HTT LRPAP1 up
## chr1q42 0.0012270 0.0122037 0.4191760 1.757964 0 119 GNG4 C1orf198 GUK1 IRF2BP2 SNORA14B TMEM63A GJC2 MRPL55 MAP10 C1orf35 DNAH14 SIPA1L2 CDC42BPA TARBP1 ARID4B PYCR2 TRIM67 B3GALNT2 TBCE RAB4A ENAH TAF5L ARF1 ACBD3 FBXO28 LINC00184 RNU6-968P GNPAT CNIH4 SLC35F3 TRIM11 NVL FAM96AP2 ABCB10 RNF187 EXOC8 COG2 SPRTN LYST NUP133 FTH1P2 TOMM20 URB2 JMJD4 FAM89A OBSCN ARV1 GGPS1 PGBD5 WDR26 KCNK1 up
## chr8p23 0.0012837 0.0122037 0.4308778 1.720250 0 83 MFHAS1 GATA4 FDFT1 C8orf49 ERI1 FAM66B OR7E125P TNKS RP1L1 PINX1 CLDN23 MIR4659B NEIL2 LONRF1 MIR4660 TDRP DEFB1 MCPH1 FAM86B2 FAM90A2P AGPAT5 RNU6-682P RPS3AP33 CSMD1 ERICH1 RPL23AP53 SLC35G5 FAM86B1 RPS3AP35 FAM90A25P FBXO25 ZNF596 XKR5 C8orf74 FAM66E FAM90A20P MSRA OR7E10P KBTBD11-OT1 PPP1R3B TDH FAM86B3P OR4F21 up
fgsea_plot(fgsea_res$res_c2, pathways_title='C2 curated genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0012771 0.0167229 0.7340737 3.016537 0 105 PRSS33 ZG16B PRSS22 C16orf91 JMJD8 TRAF7 SOX8 RAB11FIP3 NME3 PAQR4 SNRNP25 METRN TBL3 HS3ST6 POLR3K WDR24 C1QTNF8 TELO2 SRRM2 FLYWCH2 RHBDF1 PRSS27 AXIN1 MRPS34 WDR90 CCDC78 NTHL1 GFER RPUSD1 UBE2I IFT140 KREMEN2 ZNF598 NPRL3 MPG STUB1 CAPN15 DECR2 TNFRSF12A SSTR5 TSR3 PDIA2 EME2 LUC7L HAGH TSC2 NDUFB10 PIGQ NUBP2 LMF1 RHOT2 MAPK8IP3 KCTD5 CLDN9 CHTF18 NME4 THOC6 WFIKKN1 SLC9A3R2 CLDN6 PKD1 GNPTG ZNF205 HAGHL RAB40C MRPL28 RPS2 CLCN7 ZNF213 FAHD1 RGS11 RHBDL1 IGFALS up
## COLDREN_GEFITINIB_RESISTANCE_DN 0.0011521 0.0167229 0.6341447 2.836635 0 206 TMC5 ADAP1 PRSS22 KCNMB4 SLC1A1 RASEF SLC35A3 EPS8L1 CYP2J2 STARD10 MARVELD3 KIAA1522 MBOAT1 SPINK2 SYTL5 EXPH5 TJP2 REPS2 MYO6 WLS LIMA1 TMEM30B TTC22 PPL LIPH TACSTD2 GUK1 SMAGP STAP2 SMIM22 ST14 TMEM54 GNAS CST6 AGR2 LRG1 ELF3 LSR GALNT3 LNX1 STK39 FRMD4B CDH1 BIK EPN3 GRHL3 ADK C6orf132 SCAMP2 B3GNT3 TBC1D8B LAD1 MROH1 CNKSR1 CDS1 CLDN9 RAB25 C1orf21 MYO1D PRSS8 CGN EPHA1 DOK7 SVIL EPS8L2 OVOL1 RIPK4 HS3ST1 GRHL2 MACC1 TJP3 ESRP2 C1orf116 ERP27 OVOL2 SH3BGRL2 SH3YL1 SPINT1 PLEKHA7 MYH14 WEE1 MPP7 SPTLC3 EHF FXYD3 RNF114 AP1M2 HMGCL MST1R RBM47 SLC44A3 GPR160 TSPAN1 IRF6 KLC3 CDH3 GRHL1 FAM110A KIAA1211L RHOD RAB11FIP4 KRT19 PRR15L SMIM5 MAL2 MAPK13 DDR1 ELMO3 TMEM45B AIG1 KANSL1-AS1 CAPN8 LMO7 ENPP5 PITPNM3 ERBB3 VAMP8 FAM171B MFSD6 up
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0010953 0.0167229 0.6001352 2.781461 0 308 RNF207 SUN1 SLC52A3 ATAD3B ATAD3A EIF3B MTOR RNPS1 FBXO44 SRRM2 KCTD13 FNBP4 SMARCA4 TMEM201 RCC1 CC2D1B GFER TBC1D22B FBXL19 MARK2 IL17C FBXL18 ZNF598 TARDBP ANKRD54 SNHG3 CAPN15 MIIP HHLA3 KAT8 INTS1 EVI5L REXO1 TMEM63A RTKN LSM14B SETD1A ZC3H7B MDN1 POLM NSUN4 PTBP1 SRCAP CSNK1G2 TRMU ZMYND19 GAS5 ATXN2L HIP1R HPCA TICAM1 XPO5 AGRN MAPK8IP3 PHKG2 TMEM259 CMTR1 EYA3 CDC42EP1 STK11 SRRT PPP1R12C TEAD3 CCAR2 ZNF646 ABCF3 TNPO3 PPP6R2 CPSF7 PIP5K1A COPS7B LRCH4 SMG5 L3MBTL2 SNAPC4 HDAC7 SF1 SCAF1 RHBG ZNF473 CACTIN NPIPB3 HSF4 TRABD PICK1 TNPO2 MICALL1 GBA2 LTB4R ZNF316 CTNND1 DAGLB TMEM86B EPN1 RPL18 MAP2K2 ZNF133 AP5Z1 SBNO2 LEMD2 ACIN1 KDM4A ZNF692 GIGYF1 AMPD2 PHF5A SZT2 SGSM3 APBA1 GATAD2A KLF16 ILF3 KCNK5 BRD1 SFSWAP DOT1L FANCA LMNA RANGAP1 PDXP RBM33 ARMC6 GRIPAP1 C7orf26 ZBTB7B CSNK1E MAPRE3 RABGAP1 PPARD SMG7 DHX33 ARHGEF2 U2AF2 PPM1G PUS1 PPRC1 CLASRP TAF1C TRRAP LPAR2 GPC2 TTC17 UBAP2L SH3BP5L ARHGEF11 LIMK2 MYPOP SUGP2 KHSRP ZNF202 R3HDM4 MYO9B ZNF638 GGA1 NSUN5P1 ZMIZ2 HAUS8 MAPK11 GLP1R ABCA7 SPON2 SPPL2B FBRSL1 AP5S1 URB2 KMT2D NUP214 CAMK2B TCOF1 LARP1 TPM2 RASSF7 POLR2F SLC12A9 DAZAP1 USP21 SCUBE1 SAFB2 SLC39A3 THOC2 B4GALT1 MOGS UQCC2 NEURL4 up
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 0.0011148 0.0167229 0.5976224 2.724353 0 256 GALE TMC5 BAIAP2L1 AURKAIP1 GIPC1 RASEF SLC35A3 TTLL12 MYO10 STARD10 GSS VSIG2 PACSIN2 MYO6 CHMP1A SMARCA4 TMEM30B FDFT1 TTC22 SLC2A10 ICA1 RNF128 HDAC1 PREP TACSTD2 BTBD3 TRAK1 CIB1 GMDS TSPAN8 IL20RA ST14 MRPS18A AGR2 SLC22A23 VSIG10 ELF3 PLS1 GALNT3 TMEM63A DDAH1 CHMP4C ZGPAT AGR3 NADSYN1 IFI27 FUT2 HIP1R SCAMP2 TOX3 C1GALT1 RRBP1 GNA11 MROH1 ABCD3 VPS37B TMEM259 RAB25 GFPT1 KDELR2 STYK1 RPS6KA1 EPS8L2 C4orf19 MRPL14 MVP TNIP2 ZMYND8 ARRDC1 TSTA3 TJP3 ESRP2 C1orf116 JTB DOK4 OVOL2 SH3BGRL2 NET1 SYTL2 EIF2B5 EPCAM FRK GRTP1 FNIP2 MANSC1 EHF FXYD3 RABEP2 SART1 MGLL LRRC8B CC2D1A ABHD17C GSTK1 CLPTM1L PLAC8 GPR160 SRPK1 CTBP2 SGSM3 SGPP2 TRAF4 CAMK2N1 RRP7A RNF126 PLEKHJ1 MKNK2 MLPH PSMB10 MARVELD2 MED16 MT-ATP6 TNFSF10 RABL6 AACS ERBB3 EPHB4 POP7 CANT1 MRPL41 OXLD1 ESRP1 CCDC107 AKAP13 DOHH TUBA4A TOMM40 LZIC CRB3 QSOX1 FA2H ATP8B1 TMEM125 C3orf52 SLC35D2 DNAJB2 EIF4G1 HDLBP RALA RALY NOSIP ABCC3 MRPL52 BPHL up
## CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 0.0010650 0.0167229 0.5674392 2.676135 0 406 PDXDC1 TFF1 KIAA0319L SUN1 USP18 SLC52A3 ZG16B ENTPD2 KIAA0556 DEGS2 GSPT1 TTC39A JMJD8 DAAM1 AAGAB DDI2 CASZ1 IQCE NME3 RASEF PAQR4 ANK3 EPS8L1 TMPRSS2 FAAH STARD10 MARVELD3 PRR15 KIAA1522 EXPH5 RHBDF1 CACNA1D MYO6 TMEM30B SHANK2 CYB5A ICA1 SLC29A2 COG7 SLC37A1 SH2D3A FAM214A TRIB3 TMEM184A ST14 CNNM4 NR2F6 FREM2 MYO5B GGCT DLG3 AGR2 SLC25A29 ELF3 LSR LNX1 MYO5C ZXDC MSX2 CHMP4C CDH1 TRPM4 CYB561 ARHGEF5 BIK EPN3 PPP2R5A HIP1R TLE3 C6orf132 SERINC2 SCAMP2 ISG20L2 TOX3 GPR157 LAD1 CDS1 SIGIRR RAB25 ARFIP2 MYO1D PRSS8 HID1 CGN SEPHS2 ABAT EPHA1 TFF3 DOK7 FOXA1 HOOK1 PRLR PGAP2 TMED3 EPHB3 C4orf19 ZHX2 IGFBP2 SPATA2L RUSC1 OCLN OVOL1 MAP7 GRHL2 MACC1 ARRDC1 TJP3 LMTK3 ESRP2 KIAA1324 JTB WFS1 OVOL2 PPP1R16A SH3YL1 SPINT1 TM7SF2 HOOK2 MYH14 RAB40C TMPRSS13 EPCAM ALDH4A1 INPP5J MPP7 BCR SLC9A3R1 PLEKHA6 EHF FXYD3 RABEP2 AZGP1 GPD1L CBLC AP1M2 TPD52L1 TMEM134 ZKSCAN1 RBM47 GPR160 GGT6 PKP3 PER2 TRIM3 RSPH1 TNKS1BP1 RMND5B TSPAN1 IRF6 UBQLN4 CDH3 PROM2 SFI1 DBP GRHL1 FAM110A CERS6 KIAA1211L ZNF74 TRAF4 RAB11FIP4 KRT19 PRR15L RHPN1 MAL2 ARFGAP2 CAMSAP3 CAMK2N1 TADA2B DDR1 ELMO3 CKMT1B TMEM45B ZBTB7B MMEL1 MKNK2 MLPH CAPN8 P4HTM TTC9 TSPAN13 NPDC1 MRFAP1L1 PATZ1 MARVELD2 RAB27B PPM1H TSTD1 ERBB2 MUCL1 ENPP5 ERBB3 FAM102A CADPS2 MRPL41 LIMK2 NEBL ESRP1 SOX13 ZBTB42 TBC1D30 FA2H TMEM125 FEM1B TMEM183A PPCS ROGDI ZNF467 EPB41L4A ARHGAP8 MB SSH3 RAB17 TMEM191A RALGPS1 CSAD ZNF385A PCDH1 MPZL3 RNF103 EFNA4 SELENBP1 DHRS13 C1orf43 PCK2 MGMT SCYL3 FANCF ABCC11 SPINT2 DNAJC1 up
## WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP 0.0012376 0.0167229 0.5920033 2.514120 0 134 SH3RF1 RASEF SLC35A3 MYO10 MYO6 ARHGAP12 TMEM30B FDFT1 RNF128 CYP51A1 GMDS TSPAN8 VSIG10 PLS1 GALNT3 DDAH1 STK39 CHMP4C AGR3 GOLPH3 EDEM3 TOX3 ABCD3 GFPT1 CMPK1 KDELR2 CASK SYT13 CA2 MAP7 ASPHD2 TSTA3 BRI3BP DOK4 SH3BGRL2 NET1 CLDN23 NME7 SYTL2 EPCAM FRK GGT1 GRTP1 FNIP2 TMED4 PHLDA2 SLC39A14 LRRC8B ABHD17C PLAC8 GPR160 CTBP2 ABHD2 SGSM3 GDA ETNK1 HINT3 MAL2 PERP SH2D4A LYZ SLC39A11 SAR1B ELOVL6 ERBB3 EPHB4 ESRP1 GPATCH4 QSOX1 ATP8B1 C3orf52 SLC35D2 RALA NUDT15 ABCC3 OCIAD2 KCNK1 BZW2 PBLD GALNT7 ETFB MUC1 CD24 GALNT4 FZD5 KIAA1841 F11R up
## REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION 0.0013004 0.0167229 0.6146011 2.435640 0 86 RPL13 RPLP0 RPS21 RPS5 RPL24 EEF1A2 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A EEF2 EEF1D RPS26 RPS4X RPS3A RPS7 RPL36AL EEF1B2 RPL5 RPL27 RPL23A RPL23 RPL30 RPL14 RPS16 RPL41 up
## REACTOME_RRNA_PROCESSING 0.0011751 0.0167229 0.5482568 2.419179 0 184 TBL3 NOB1 EXOSC10 NIP7 BMS1 ERI1 UTP14A PWP2 EXOSC6 NOP2 NOC4L PES1 RPL13 TSR3 NSUN4 RPLP0 RPS21 ISG20L2 RPP25 NOL9 NOP14 RPS5 RPL24 XRN2 RPLP1 RRP9 RPL10A RPL22 NOL6 RPL39 RPS3 RPL29 DHX37 RPL18A FAU RPS2 BOP1 RPL18 RPSA RPL36 RPS12 RPS28 WDR18 RPL13A RRP1 RPL35 DDX49 THUMPD1 TSR1 RPS14 RPS13 RRP7A RPS11 LAS1L IMP3 TRMT112 RPL32 RPL3 EBNA1BP2 NOP56 RPL12 UTP18 RPLP2 PELP1 CSNK1E RPS15 RPL11 NCL NAT10 RPL34 RPS15A RPL9 UTP20 RPS23 WDR3 RPS8 EXOSC5 EXOSC2 HEATR1 RPS29 RPL31 CSNK1D RPS27A UBA52 MPHOSPH10 IMP4 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPP38 RPS4X RBM28 RPS3A UTP6 RPS7 RPL36AL up
## KEGG_RIBOSOME 0.0013175 0.0167229 0.6162810 2.417764 0 81 RPL13 RPLP0 RPS21 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPS4X RPS3A RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 RPL30 RPL14 RPS16 RPL41 up
## NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON 0.0012376 0.0167229 0.5691117 2.416904 0 134 NTSR1 DIDO1 TAF4 MRGBP HELZ2 YTHDF1 OSBPL2 CABLES2 PRPF6 ADRM1 UCKL1 SPATA2 TCFL5 GID8 PMEPA1 ZNF512B GNAS SS18L1 SLC2A4RG OGFR LSM14B VAPB ARFGAP1 ZFP64 PCK1 ZGPAT RPS21 PARD6B SDC4 TFAP2C MTG2 TMEM189 MATN4 RBBP8NL ARFGEF2 DNAJC5 EEF1A2 COL20A1 ARFRP1 RTEL1 NELFCD ZMYND8 LAMA5 SLCO4A1 SEMG1 CDH4 SAMD10 ATP9A KCNQ2 TOMM34 RNF114 PSMA7 GMEB2 TPD52L2 RAB22A PI3 SALL4 CHRNA4 NPEPL1 TSHZ2 SLC9A8 ABHD16B up
## HOLLERN_EMT_BREAST_TUMOR_DN 0.0012563 0.0167229 0.5774255 2.412243 0 114 ATP6V1C2 SHROOM3 ARHGEF16 EPS8L1 TMPRSS2 WWC1 STARD10 RHPN2 TMEM30B ILDR1 STAP2 TMEM184A ST14 TMEM54 MYO5B EPB41L4B PTPRF LSR CDH1 HIP1R TFAP2C ELOVL7 KIF21A RAB25 PRSS8 EPHA1 EPS8L2 EFNA3 OCLN OVOL1 MAP7 RIPK4 GRHL2 TJP3 ESRP2 SPINT1 MYH14 TMPRSS13 EPCAM LRBA EHF FXYD3 CBLC AP1M2 PKP3 CELSR2 IRF6 KLC3 CDH3 GRHL1 MAL2 TNK1 DDR1 CKMT1A ELMO3 MARVELD2 PLEKHG6 ERBB3 ESRP1 EVPL SORT1 CRB3 C1orf210 CDCP1 CEACAM1 CCDC120 POF1B SPINT2 KCNK1 CHDH ACOT2 THRSP JUP GRB7 PLEKHH1 CD24 up
## VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_DN 0.0012438 0.0167229 0.5671266 2.404907 0 133 LGALS4 ODAM FAM3D REG4 TMC5 ALDOB TFF2 RER1 SNRNP25 TMPRSS2 GCNT3 LPCAT4 STARD10 GATA4 RHPN2 PTPRN2 VSIG2 CLRN3 CES2 CFTR LIG3 SLC4A4 CYSTM1 SULT1A2 GMDS ARX GOLM1 EPN3 VILL CA13 TFF3 PRSS3 DPP3 BTNL8 CA2 CALML4 IFT57 KIAA1324 REG1A CLDN23 FXYD3 CLDN18 BCL2L15 ENTPD3 HSD17B2 GSDMB GP2 AADAC WNK4 DOT1L NAT1 REEP6 CKMT1B TMEM45B ZBTB7B SENP8 MLPH up
## REACTOME_NONSENSE_MEDIATED_DECAY_NMD 0.0012594 0.0167229 0.5796541 2.402852 0 108 GSPT1 RNPS1 RPL13 SMG1 RPLP0 RPS21 RPS5 RPL24 RPLP1 SMG5 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A UPF3B RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 SMG7 ETF1 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 MAGOH EIF4G1 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 UPF1 RPS4X SMG6 RPS3A RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 RPL30 PPP2R1A RPL14 RPS16 RPL41 up
## REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY 0.0012920 0.0167229 0.5968259 2.396955 0 94 TRIB3 RPL13 RPLP0 RPS21 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 DDIT3 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 ASNS RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPS4X ATF4 RPS3A RPS7 RPL36AL RPL5 RPL27 EIF2AK4 RPL23A RPL23 RPL30 RPL14 RPS16 RPL41 up
## REACTOME_EUKARYOTIC_TRANSLATION_INITIATION 0.0012610 0.0167229 0.5711223 2.381376 0 112 EIF3B EIF3I RPL13 RPLP0 RPS21 RPS5 RPL24 EIF2B3 RPLP1 RPL10A RPL22 EIF3L EIF2B5 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA EIF3D RPL36 RPS12 RPS28 RPL13A EIF3C RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 EIF2B2 RPLP2 RPS15 RPL11 RPL34 EIF3G RPS15A RPL9 RPS23 RPS8 RPS29 EIF4G1 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A EIF3M RPS26 RPS4X RPS3A EIF5B EIF4EBP1 RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 RPL30 EIF3J RPL14 RPS16 RPL41 up
## LIM_MAMMARY_STEM_CELL_DN 0.0010695 0.0167229 0.5041419 2.372165 0 387 GABRP GALE KIAA0319L SLC5A1 ARHGEF16 BAIAP2L1 RER1 CASZ1 SMIM1 GIPC1 SLC35A3 KIF1B TMPRSS2 FAAH STARD10 MARVELD3 KIAA1522 MBOAT1 FADD RHPN2 EPB41 PACSIN3 ZNF334 SUSD4 MPI ILDR1 ICA1 PPL FGF13 LIPH SLC37A1 CIB1 STAP2 ST14 TMEM54 NGEF MYO5B DLG3 ANO9 DECR2 ELF3 ALG8 PTPRF IFI35 LSR MYO5C TIRAP CDH1 GOLM1 BIK TMEM139 HAGH TMEM62 KRT8 LGALS3BP MTUS1 RAB11FIP1 COASY HMGXB4 SIGIRR RAB25 VILL HID1 CGN ADAT1 DHCR7 FOXA1 DBNDD2 VTCN1 AP1G2 PRLR PGAP2 TMED3 SNX8 ACOT8 MVP HOMER2 TLR3 CA2 RMDN3 ARRDC1 PAK1 TJP3 KIAA1324 SPINT1 TM7SF2 MYH14 RPL22 ATP6V0E2 HLCS TMPRSS13 EPCAM FRK LRBA SLC22A18 GRTP1 MANSC1 SLC9A3R1 BARX2 PIGO CBLC CPT2 HDHD3 AP1M2 ATG2A ABHD17C GSTK1 TFAP2A RBM47 DHCR24 CXCL17 ARPC1A SGSM3 TOM1L1 IBTK BDH1 GRHL1 FAM110A WNK4 RAB11FIP4 FAM221A KRT19 COBL CAMSAP3 NAT1 MAPK13 TPCN1 ELMO3 REEP6 ZSCAN20 SLC16A5 RFX1 GCC2 ALDH5A1 MLPH RABGAP1 SLC39A11 CTPS2 PPM1H PXMP2 ERBB2 CORO2A RAD51D ERBB3 OXLD1 ZDHHC12 EVPL OS9 PDZK1IP1 CLDN8 ZSWIM4 CRB3 NCOA2 TMEM125 IFT43 C1orf210 SLC35D2 ZFAND2B TCIRG1 MTA3 CGNL1 MB SSH3 CCT6B ANKRA2 SNRNP35 RALGPS1 RREB1 PRKCZ NUDT1 RASSF7 WFDC2 CEACAM1 SLC39A9 up
## LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 0.0010142 0.0167229 0.4874588 2.353193 0 716 GALE RERE FBXO42 VPS13D SSU72 SPEN CEP104 KIAA0319L UBR4 SRSF4 ANKRD13C DNAJC16 DNAJC11 SLC9A1 THRAP3 ZSWIM5 UBE4B ACAD8 PHACTR4 ATP13A2 TTC39A SCMH1 ZMYM4 DDI2 DYNC2H1 RER1 TRNAU1AP AKR7A2 SRRM1 MFN2 COA4 B3GALT6 AKR7A3 PER3 TRAPPC3 C2CD3 TMEM234 EIF4G3 WRAP73 PHF13 FAF1 PANK4 KIF1B SESN2 MTOR MSANTD2 UBE2J2 BSDC1 NBPF3 DHDDS YTHDF2 KIAA1522 NADK ARHGAP32 BAD LYPLA2 NUMA1 RNF169 POLD3 GPN2 NCDN ZBTB48 TXLNA ZBTB17 EPB41 LRRC47 RSF1 PEF1 FAM76A TMEM201 CDON TMEM222 MTFR1L ICMT ARHGEF10L EXOSC10 CCNL2 C1orf122 ZNF362 ADPRHL2 POMGNT1 SC5D TPRG1L SDF4 DGAT2 STK40 FNDC5 ERI3 DCUN1D5 ZMYND12 AHDC1 TRAK1 MICU1 KPNA6 LRRC41 MEAF6 MAP7D1 PPME1 SDHB CREBZF PUM1 RHCE EMC1 KIAA2013 SPATA6 NARS2 MIIP LDLRAP1 PEX14 IPP ALG8 PTPRF CLSTN1 PAFAH2 EFCAB14 TP73-AS1 MIB2 FGFBP3 NSUN4 ARHGAP1 FOXRED1 LETM1 GPBP1L1 ZMPSTE24 SZRD1 LEPR CLPB ARID1A COL9A2 NOL9 LRTOMT CROCCP2 NOP14 TMEM126B ELOVL1 UBIAD1 CMPK1 ZBTB8A INTS4 MRPL48 RPS6KA1 LAMTOR1 ASAP3 SYNC PARK7 AKIRIN1 MUL1 DLG5 TNFRSF25 CLNS1A TRIM62 ME3 MTF1 AK2 NUDC RLF CEP85 UBE4A DDOST MAST2 CTNNBIP1 PAK1 PPP1R8 ZYG11B CMTM8 NELFA PIK3R3 CTBP1 MAD2L2 GLB1L2 PRDM2 GRPEL1 WDTC1 SNIP1 PCF11 RPS3 DNALI1 MANEAL TAF12 STX12 HECTD3 S100PBP RNF4 CPLX1 SF3A3 PRPF38A THAP3 IPO13 C1orf216 MARCKSL1 GAK HMGCL PPIE KDM4A PLEKHM2 CPEB3 MACF1 STT3A CTBP2 MED8 FAM193A SZT2 CLCN6 MAEA HIVEP3 PINK1 AGO3 RNF11 KHDRBS1 NMNAT1 PITHD1 CTDSPL TXNDC12 GNB1 TBRG1 TACC3 CCDC85B APLP2 BLOC1S4 PAAF1 ZMYM1 HK1 GLB1L3 VAMP3 RPL32 EXO5 EBNA1BP2 MAN1C1 PIGG NEAT1 MRFAP1 SNRNP40 TMEM51 DPF2 HPCAL4 TMEM175 CC2D2A MFSD10 GOLGA4 PAQR7 BTF3L4 ZBTB8OS MRFAP1L1 ATPAF1 ASRGL1 FOXJ3 SIK3 USP48 DNAJC6 WDR78 PCGF3 TIMM8B LRRC42 INPP5A OSBPL9 NFIA TSKU RBBP4 TAF1D PIGV RNF220 LCOR DHX15 SPSB1 EPHA10 NDUFC2 DNAJC8 ZCCHC17 ZNF202 SNX19 UVSSA MED18 LZIC CHD5 AGO4 CAMTA1 ACOT7 ZBTB8B IFIT5 ATXN7 NASP SCP2 SLBP PRDM10 PPCS ZNF684 BEND5 RPUSD4 THYN1 ECE1 TMEM59 KRBOX1 VGLL4 BMPR1A PRKCZ BUD13 up
## NIKOLSKY_BREAST_CANCER_7P22_AMPLICON 0.0014451 0.0167229 0.6853062 2.342870 0 36 SUN1 ADAP1 GET4 IQCE EIF3B GPER1 MAD1L1 FBXL18 TMEM184A TNRC18 WIPI2 INTS1 PSMG3 SNX8 BRAT1 CHST12 AP5Z1 COX19 SLC29A4 C7orf50 MICALL2 FOXK1 FAM20C AMZ1 up
## REACTOME_METABOLISM_OF_RNA 0.0010256 0.0167229 0.4860483 2.338864 0 626 TYW1 SRSF4 GSPT1 SRRM1 PSMC6 EDC4 MNAT1 SNRNP25 CTU2 TBL3 NOB1 RNPS1 RPPH1 SRRM2 PRPF6 USP39 EDC3 EXOSC10 NIP7 BMS1 CD2BP2 ERI1 UTP14A APOBEC1 PUS7 CWC25 AKT1 TRIT1 PWP2 SF3B3 METTL3 EXOSC6 CHERP NOP2 NOC4L TRMT61A TSEN54 PES1 RPL13 TSR3 GTPBP3 SMG1 NSUN4 PTBP1 RPLP0 RPS21 TRMU SF3A2 ISG20L2 RPP25 NOL9 CTU1 PSMA5 RNPC3 GEMIN4 NOP14 NUP160 PSMD3 SRRT PSMD11 ADAT1 PSMB2 RPS5 RPL24 NSUN2 THOC6 A1CF CLNS1A SNRNP200 XAB2 LSM5 XRN2 TP53RK NXT1 TRMT1 PSMA3 CPSF7 RPLP1 DHX38 TRMT11 SNRPD3 SRSF1 RRP9 SMG5 GEMIN8 TRMT5 RPL10A PRPF8 SF1 RPL22 ZNF473 NOL6 TRMT12 PCF11 RPL39 RPS3 PSMC3 SNRPB RPL29 DHX37 RPL18A POLDIP3 FAU SART1 RPS2 PSMA7 PPIL6 SF3A3 PRPF38A BOP1 RPL18 RPSA WDR77 PPIE CDC5L RPL36 POLR2L RPS12 TFIP11 RPS28 WDR18 RPL13A UPF3B TNKS1BP1 PHF5A NUP93 PRCC RRP1 NUP205 RPL35 PRMT5 DDX49 DDX46 PSMD12 THUMPD1 TSR1 RPS14 RPS13 RRP7A TRMT6 RPS11 LAS1L IMP3 TRMT112 RPL32 RPL3 PSMA6 EBNA1BP2 NOP56 RPL12 UTP18 SNRNP40 ELAVL1 GTF2F1 POLR2C RPLP2 PELP1 POLR2J CSNK1E AQR RTCB PSMB10 TRMT44 NUP88 RPS15 RPL11 DDX23 SMG7 PARN ETF1 CSTF2 APOBEC3B ZBTB8OS ADAT3 PAIP1 PAN2 PSMB5 U2AF2 SF3B2 LCMT2 NUP98 NCL NAT10 PUS1 PRPF19 DHX9 FUS PRKCA TXNL4A PSME2 APOBEC4 POP7 RPL34 RPS15A ADARB1 POLR2E ADAR RBM17 GTF2H3 DHX15 RPL9 DNAJC8 KHSRP UTP20 PSMC1 RPS23 SRSF7 WDR3 NUP50 RPS8 DCPS METTL1 TRDMT1 NUP133 MAPK11 EXOSC5 IGF2BP1 EXOSC2 HEATR1 RPS29 SLBP LSM4 TSEN2 MAGOH DDX39A HNRNPUL1 EIF4G1 SF3A1 NUP214 PSMF1 SNRNP35 ALYREF XPOT APOBEC2 RPL31 CSNK1D TPR RPS27A UBA52 POLR2F MPHOSPH10 IMP4 RPS20 RPL38 ZMAT5 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 SNRPD2 RPL19 RPL35A THOC2 CNOT4 RPS26 RBM22 NUP153 SNRPN WDR33 RANBP2 PSMC4 RPP38 CPSF4 HNRNPR UPF1 RPS4X SMG6 DUS2 SNRPB2 NDC1 RBM28 RPS3A UTP6 RPS7 RPL36AL UBC SUPT5H PDCD7 RPL5 SNUPN LSM10 DDX42 IGF2BP3 GEMIN6 PSME3 CNOT11 RPL27 SRSF9 SRSF11 RPL23A PPIH BUD31 WDR4 RPL23 APOBEC3A RPL30 SNRPA ELAVL2 PPP2R1A NUP188 SNRNP70 ZFP36L1 ANP32A CCAR1 RIOK2 RBMX RPL14 PUS3 NUP85 QTRT1 NOP10 PSMC2 RPS16 GTF2H5 RPL41 CSTF1 SRSF10 SMN2 HNRNPF PSMD1 SNRPC GEMIN5 FTSJ3 PSMD4 EFTUD2 WDR43 NUDT21 ERCC2 PSMD13 ELAC2 SNRPE UTP3 SRSF6 RPL37 DDX20 PSMA1 SENP3 MAPK14 IGF2BP2 RPL8 PSMB4 POLR2A POM121C CNOT1 DDX47 RPL15 TRMT10C NHP2 SF3B5 MAGOHB WDR36 CASC3 NOL12 ZC3H11A PSMD2 PATL1 GCFC2 TSEN15 SNW1 POLR2H PHAX SNRPA1 POLR2I UPF2 SUGP1 RPL26L1 ZRSR2 LSM1 NOL11 THOC1 GTF2H1 PSMD7 DCP1A THG1L PABPN1 PSME4 ERCC3 PSMC5 HNRNPA2B1 up
## REACTOME_INFLUENZA_INFECTION 0.0012225 0.0167229 0.5441887 2.335184 0 145 ISG15 KPNA7 RPL13 RPLP0 RPS21 NUP160 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA CLTA RPL36 POLR2L RPS12 RPS28 RPL13A NUP93 NUP205 RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 GTF2F1 POLR2C RPLP2 POLR2J NUP88 RPS15 RPL11 EIF2AK2 NUP98 RPL34 RPS15A POLR2E RPL9 RPS23 NUP50 RPS8 NUP133 RPS29 NUP214 RPL31 TPR RPS27A UBA52 POLR2F RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 GRSF1 NUP153 RANBP2 CPSF4 RPS4X NDC1 RPS3A RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 RPL30 NUP188 RPL14 NUP85 RPS16 RPL41 up
## LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 0.0011547 0.0167229 0.5221859 2.333088 0 202 MIPOL1 SLC4A2 FADD PPFIA1 NUMA1 ZNF3 INPPL1 LY6E AKT1 BLCAP TAF6 FASTK MTRR CDK5 ABCF2 TFDP1 CCDC85C DHCR7 LAMTOR1 DPP3 TSTA3 PIP5K1A JTB KCNH2 PPP1R16A SDHA CLCN2 STRN3 ZSCAN21 EGFR BAZ1A TMEM134 RMI2 CLPTM1L USP13 C14orf132 GNB2 PI4KB PRCC CCDC127 NKX2-1 ZNF74 MAGEF1 YKT6 CAV2 POLR2J ALKBH4 NDUFS6 HDGF JPH1 DDIT3 DVL3 SLC12A7 DAP SHC1 TRIM44 MRPL11 NAT10 PAX9 FKBP9 YY1 PI4KA RAD23A ADAR ARHGEF11 CCDC107 NPR1 NRDE2 MET METTL1 PDCD6 COCH LPCAT1 EAPP EIF4G1 MANBAL TMEM191A NUDT1 PBX1 SEC61G MRPL23 USP21 RPS27 SSR2 ZNF277 NUBP1 AGO2 COPS6 CCS DDX10 HAX1 FAM131A CERS2 FIGNL1 GCDH PMVK PARD3 AP4S1 SRP54 CCT5 ABCC5 SRD5A1 POGZ CDK4 SEC23A DUSP12 CD44 IGSF8 TPM3 RTN4R S100A13 MED15 TECPR2 PYGO2 CRKL KDM2A DENND4B MCM7 MAF1 TTC8 SLC39A1 ANAPC15 FAM177A1 PSMB4 PPP1R3D SIVA1 up
## LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_DN 0.0012853 0.0167229 0.5673472 2.322652 0 103 ZG16B TTC39A SCGB2A1 ZDHHC11 FAM214A IL20RA CST6 AGR2 SERTAD4 RTN4RL1 MYO5C CDH1 AGR3 BIK EPN3 ELF4 HID1 ABAT TFF3 FOXA1 IFI44L HCAR1 PRR5-ARHGAP8 GRHL2 KIAA1324 OVOL2 EPCAM DNALI1 INPP5J SLC9A3R1 PLEKHA6 FXYD3 AZGP1 MANEAL AP1M2 P2RY2 DHCR24 RSPH1 KRT19 PRR15L MAL2 NAT1 REEP6 MMEL1 FBXL16 NPDC1 TSTD1 ERBB2 MUCL1 STK16 CRB3 TMEM125 MB SLC25A4 KRT18 ZFP62 ABCC11 SPINT2 up
## CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 0.0010787 0.0167229 0.4947142 2.312395 0 356 SUN1 EDAR DNAJC16 ARHGEF16 ADCY9 DEGS2 OR7E14P SCMH1 CYB5B UPK1B LMTK2 EPS8L1 SNORA74A KAZN KIF1B ACSS2 FAAH MARVELD3 SLC2A13 NAPEPLD TJP2 NFAT5 SERTAD4-AS1 SLC6A20 SHH ICMT PPM1A ILDR1 PPL ZMYND12 IFT140 SMAGP GMDS IL20RA GLOD4 ST14 FREM2 CAPN1 KIAA2013 ELF3 PLS1 GALNT3 CLSTN1 VAPB CUX1 TM7SF3 NFATC2IP LCN2 TMEM139 LRRC57 GPBP1L1 C6orf132 SNTB2 SERINC2 UBXN10 LMF1 BCAR1 CCDC148 PSMA5 PTPRK CDS1 EZR PRSS8 GTF2I PRKAA2 ANXA11 EPHA1 ZBTB18 IQCH LRRK2 C12orf75 OCLN MAP7 NAALADL2 RSPH3 MACC1 CLDN12 RND2 STAG3L3 TJP3 TRIOBP LMTK3 BEND7 GALNT11 ITFG1 PLEKHA7 SPATS2L EPN2 HYDIN PDF SYTL2 OSCP1 SPTLC3 CLIC6 FOXC1 GATM EFCAB6 SOSTDC1 PDSS2 RBM47 AHR KCNJ15 PCLO TSPAN1 LINC00899 GRHL1 KIAA1211L KCNK5 CNKSR3 COBL PRR15L AGO3 KITLG LRRFIP2 GK5 EXO5 GATAD1 FAT1 CKMT1B DLG1 FBXL16 MSI2 SIK2 FUT3 P4HTM ASRGL1 CDC42BPG ATXN1L LMO7 WDR78 FHDC1 TNFSF10 NFIA SH3D19 PIGV MMP15 SUMF2 MET CAMTA1 LIME1 TMEM125 EVC EXOC4 FAM81B C1orf210 BBS2 RPS6KA2 SLC39A8 SPAG6 GORASP1 TINAGL1 NLRX1 WFDC2 BPHL SEL1L3 MON1B PHACTR2 BBS4 PITPNA DMTF1 SIPA1L1 LRPAP1 FZD1 FOXP4 up
## REACTOME_TRANSLATION 0.0011186 0.0167229 0.5054518 2.306877 0 262 GSPT1 MRPL20 AURKAIP1 EIF3B MTFMT MRPS34 FARSB MRPS18A EIF3I NARS2 TUFM RPL13 MRPS6 RPLP0 RPS21 MRPL55 AIMP2 EARS2 MRPL49 MRPS15 MRPL48 RPS5 RPL24 MRPS2 MRPL14 EEF1A2 EIF2B3 DDOST RPLP1 RPL10A RPL22 EIF3L MRPL28 EIF2B5 RPL39 RPS3 RPL29 RPL18A FAU MRPL17 RPS2 MRPS26 RPL18 RPSA EIF3D RPL36 RPS12 RPS28 RPL13A EIF3C FARSA RPL35 DAP3 ERAL1 RPS14 RPS13 RPS11 TRMT112 RPL32 RPL3 RPL12 EIF2B2 MRPS35 AARS2 RPLP2 MRPL37 RPS15 RPL11 ETF1 MRPL54 MRPL11 GADD45GIP1 RPL34 EIF3G RPS15A MRPS11 MRPL41 RPL9 RPS23 RPS8 MRPS33 RPS29 MRPL24 EIF4G1 MARS2 PPA1 PTCD3 RPL31 HARS2 RPS27A UBA52 MRPL52 MRPL51 SEC61G MRPL23 FARS2 RPS20 N6AMT1 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 SSR2 SARS2 RPS9 RPL19 RPL35A EEF2 EEF1D EIF3M AIMP1 RPS26 MRPS7 MRPL4 RPS4X MRPS30 MRPL12 RPS3A EIF5B EIF4EBP1 RPS7 RPL36AL EEF1B2 MRPL32 SRP54 MRPS23 RPL5 RPL27 YARS2 MRPS27 RPL23A SRPRB MRPL10 OXA1L RPL23 GFM2 RPL30 TARS2 EIF3J SRP14 RPL14 CHCHD1 RPS16 RPL41 MRPL34 MRPL21 MRPS28 RPN2 EIF2B4 RPL37 SEC11A MRPL46 SEC61A1 RPL8 MRPL27 SEC61A2 TRAM1 MRPL33 RPL15 up
## CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 0.0010787 0.0167229 0.4924408 2.298963 0 347 TFF1 ZNF12 KIAA0556 DEGS2 EFR3B THSD4 GSPT1 TTC39A ONECUT2 UBN1 TMEM150C DAAM1 SCUBE2 RAB11FIP3 IQCE EIF3B NME3 EPS8L1 GSE1 GTF3C1 STARD10 ZNF398 BCOR PPFIA1 TTC6 SRRM2 TSPAN15 RHBDF1 CACNA1D MYO6 DIP2C SHANK2 CCT6P3 SLC2A10 ICA1 PKP4 SLC37A1 SBK1 TMEM184A AVL9 MYO5B MGRN1 TNRC18 DLG3 AGR2 USP42 SLC25A29 RALGAPA1 LNX1 CYB561 EPN3 HIP1R TLE3 USP7 ARFIP2 HID1 KDELR2 RBAK TFF3 FOXA1 PRLR C4orf19 TAPT1 SPATA2L RUSC1 TJP3 KIAA1324 WFS1 RSAD1 PPP1R16A RAB40C ATP6V0E2 PRR14 DNALI1 INPP5J SLC9A3R1 CREB3L1 RABEP2 DUSP8 GPD1L LARP4B ZNF703 POLE GPR160 C14orf132 TRIM3 GGA3 RSPH1 MXRA8 PRRC2C SFI1 ZNF704 CERS6 ZNF74 KRT19 THUMPD1 RHPN1 CAMSAP3 LZTR1 TADA2B VPS37C C7orf26 PYCR1 SOX12 MLPH HMG20B BPTF P4HTM TTC9 TSPAN13 NPDC1 ASH1L PATZ1 PI4KA FUS ZDHHC8P1 ERBB3 SMARCC2 MYEF2 HECTD4 CANT1 LCOR SOGA1 SOX13 ZBTB42 HMGCS2 TBC1D30 MYCN GGA1 SLC38A10 ATP8B1 FBRSL1 ZNF467 KMT2D HK2 SH3GLB2 RAB17 RALGPS1 CSNK1D PBX1 RNF103 USP3 DHRS13 SEC16A PCK2 SCYL3 TESK1 DNAJC1 ANXA9 CERS2 ZNF444 CHDH IVD CTXN1 MCCC2 GRAMD4 NDUFS8 NEK5 SIDT1 ZSWIM8 SYNE4 PLEKHH1 DDX42 CCDC117 GOLT1A CAPN9 POGZ SNX27 BCAS1 TBC1D16 ULK1 KDM4B CEP350 ARHGEF26 up
## CREIGHTON_AKT1_SIGNALING_VIA_MTOR_UP 0.0014771 0.0167229 0.6951996 2.285612 0 30 ARHGEF16 SLC37A1 AKT1 CDC34 CLSTN1 CYB561 BIK KCTD5 CDK16 TJP3 SPINT1 UBE2M BRMS1 RNF126 BSG DDR1 MVK HNRNPAB MMP15 TOLLIP DUSP10 up
## NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON 0.0014045 0.0167229 0.6207054 2.275581 0 51 CTU2 GSE1 ZCCHC14 CHMP1A ZFPM1 SPATA33 IL17C SLC7A5 PIEZO1 MVD RPL13 ZC3H18 EMC8 APRT GALNS SPATA2L ANKRD11 SPG7 CDT1 CDK10 CENPBD1 SPIRE2 FANCA TRAPPC2L GAS8 ZNF276 PRDM7 DEF8 VPS9D1 ACSF3 BANP CPNE7 GINS2 ZNF778 COX4I1 TCF25 JPH3 up
## REACTOME_SELENOAMINO_ACID_METABOLISM 0.0012837 0.0167229 0.5560127 2.275027 0 102 CTH RPL13 RPLP0 RPS21 AIMP2 SEPHS2 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA AHCY RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A AIMP1 RPS26 RPS4X RPS3A RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 EEFSEC RPL30 RPL14 RPS16 RPL41 up
## REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0012837 0.0167229 0.5513437 2.259959 0 104 RPL13 RPLP0 RPS21 RPS5 RPL24 DDOST RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 SEC61G RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 SSR2 RPS9 RPL19 RPL35A RPS26 RPS4X RPS3A RPS7 RPL36AL SRP54 RPL5 RPL27 RPL23A SRPRB RPL23 RPL30 SRP14 RPL14 RPS16 RPL41 RPN2 RPL37 SEC11A SEC61A1 RPL8 SEC61A2 TRAM1 RPL15 SRP68 up
## BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 0.0011468 0.0167229 0.5031737 2.253216 0 204 DHRS3 ATP6V1C2 TFF2 TMPRSS3 ADCY9 DEGS2 RIMS4 HR SHB SOX8 KAZN WWC1 GNL2 AXIN1 NIP7 RPUSD1 LRIG1 PMM2 SLC7A5 INO80B DHRS2 LRG1 TRMT61A TSEN54 MYBBP1A FHL2 LETM1 ADAMTSL5 ISG20L2 GSG1L RAPGEFL1 UBIAD1 ASB13 DOK7 SVIL KLK10 NXT1 TJP3 WFS1 OVOL2 SNAPC4 SPATS2L RAB3IL1 NOL6 FRK PTGES SLC9A3R1 NEIL2 FOXC1 SLC2A8 MANEAL PHLDA2 IFRD1 TPD52L1 P2RY2 ZNF703 SLC2A1 ACIN1 XRCC3 CELSR2 NOLC1 CNKSR3 TIPARP BHLHE40 SIN3B NCOR2 SMOX TMEM51 MLPH FGFRL1 TUBB2B SYNDIG1 GPRIN1 PPRC1 TSKU FAM102A SRM TBKBP1 AHCTF1 AMZ1 POLR1B GPATCH4 CAMTA1 REEP1 ARHGEF18 HK2 RARA AUNIP up
fgsea_plot(fgsea_res$res_c3, pathways_title='C3 regulatory target genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## ETF_Q6 0.0012438 0.0051693 0.6013338 2.480974 0 112 RERE UBR4 SRRM1 MFN2 PHF13 FAF1 MTOR YTHDF2 MCU ZBTB17 MRTO4 FAM76A TMEM222 PRDM16 ZNF362 POMGNT1 KPNA6 ST6GALNAC5 SLC41A1 ZNF496 LRP8 EMC1 KIAA2013 SPATA6 SKIDA1 CLSTN1 ARID1A LAD1 C1orf21 CMPK1 EFNA3 RUSC1 ZFYVE9 MAST2 CTNNBIP1 KCND3 KDM1A CAMK1D NFYC MARCKSL1 CELSR2 RASAL2 DAP3 AGO3 ARTN PITHD1 GNB1 VAMP3 MAN1C1 HPCAL4 ASH1L YY1AP1 USP48 ATXN7L2 WDR78 NFIA TRIM33 RNF220 SOX13 AGO1 XPR1 SSBP3 RPRD2 USP21 C1orf43 CAMK2G SCYL3 up
## THAP1_TARGET_GENES 0.0009990 0.0051693 0.4550303 2.262442 0 1667 TYW1 VPS13D SSU72 KIAA0319L ISG15 FIBCD1 SLC9A1 ACTR3B ARHGEF16 NUDCD3 ATAD3A NPHP4 C16orf91 PEX10 JMJD8 MRPL20 FAM118B DNAJA3 AURKAIP1 C1orf174 HMOX2 E2F4 DIDO1 PGP GNAZ MFN2 B3GALT6 CDK11B SNX18 E4F1 FAF1 CTU2 TBL3 DHDDS GDF15 ZNF398 YTHDF1 BAD FADD MKRN3 INO80 TBRG4 MCAT WWP2 NCDN C16orf70 PRSS27 ZBTB17 PRPF6 PHLPP1 MRPS34 CCDC86 LRRC47 RSF1 RBCK1 TAOK2 PEF1 SMARCA4 TMEM222 ARHGAP12 ZNF3 WDR90 SNHG12 FAM86GP TMEM53 DDX19A ICMT STX18 UBAP2 POLR3E CDK11A ZNF747 LINC00853 RAD50 CCNL2 GBAP1 ADPRHL2 TBC1D22B ZKSCAN2 CD2BP2 RPUSD1 SDF4 NMRAL1 RCOR2 CYP51A1 STK40 PTPRU ANKRD13A GID8 IFT140 KPNA6 AP2B1 IGHMBP2 GUK1 CIB1 HMGXB3 NIPAL3 SLX4IP NPRL3 CCDC130 MPG ATP13A4 METTL3 EXOSC6 FASTKD5 STPG1 REV1 ECI1 USP42 NUDT22 WDR60 GUSB CHERP TUFM MVD NCAPH2 NOC4L CFDP1 EVI5L ZNF764 IPP LINC00337 ST7 ALG8 TRPT1 SUPT3H C15orf41 CLSTN1 ZXDC NAA60 KPTN DNPEP MDN1 PSKH1 ZDHHC5 TSR3 GTPBP3 ZGPAT ZC3H18 PLAGL2 PHF12 PTBP1 EME2 CSNK1G2 ZNF384 LMF2 TRMU MRPL55 ADAMTSL5 LINC00115 CRK ATP6V0D1 GPBP1L1 ADK LRRCC1 HPS4 TIGD4 NUBP2 HUS1 ZMPSTE24 SZRD1 UQCC1 LGALS8 TRAFD1 OGDH ISG20L2 LMF1 RHOT2 MAPK8IP3 CTU1 OTUD3 PSMA5 PRDX5 KCTD5 COASY MTG2 CROCCP2 ABCD3 MST1P2 AHCYL1 TMEM259 SLC27A5 AIFM1 WDR87 ARFIP2 MRPS15 TTPAL PIAS4 CHTF18 IQCC PPP1R12C RPS5 FAM86C1 ARFGEF2 AKIRIN1 NSUN2 PEX16 ALG1 POLR3B PGAP2 C1orf35 BBS9 MRPS2 UBOX5 SNX8 SNAPC5 TMEM219 GALNS SRI TAPT1 CYP4A22-AS1 ERI2 RRNAD1 XAB2 FBRS PEX7 GPR137 AGFG2 ZBTB45 RNF24 EPS15L1 ARFRP1 PPP6R1 CCAR2 RUSC1 AUP1 NUDC PKN2 GUCD1 DDX41 PHKB RPTOR RSPH3 CCDC113 EML4 THEM6 DNAH14 VPS51 STRADB GNPTG DDX51 DNMT1 TM9SF4 AGTRAP SIPA1L3 PPP1R8 TTC31 DHX38 KRBA1 LMTK3 SNRPD3 RPS19BP1 SAMD10 ZNF746 DNAL4 TTLL11 BAK1 DUS1L ZBTB7A ITFG1 ZNF212 SH3YL1 CAAP1 RRP9 HOOK2 SMG5 ZNF839 OSBP ZNF664 RAB40C TM9SF1 TRMT5 SSR4P1 TUBGCP6 ZNF473 GCC1 PDF BOD1 PRR14 TUBG1 CACTIN DNTTIP1 PTRHD1 TRMT12 LONP1 ZNF787 RPL39 SLC35B2 PSMC3 PYCR2 PCSK4 AP4M1 SNHG9 RPL18A CEP250 ETV3 MGME1 PARP3 ATXN10 GBA2 EP400 FBXO31 POLDIP3 CCDC137 DUSP8 RPS2 SGMS1 DPH6 TRPM7 S100PBP EPN1 TULP4 RPL18 MAP2K2 TATDN1 THAP3 CTCF ZNHIT1 AP5Z1 MIR320A C18orf25 GAK UBE2M GDPGP1 CDNF DDX55 HMGCL EIF3D RHPN1-AS1 CLPTM1L SREK1 SH2B1 DDX27 TPD52L2 RPL36 COX19 RPS12 KDM5B TFIP11 PKP3 ATG16L1 TRIM41 TAX1BP1 WDR18 PLOD3 RANBP1 TAF5L CLCN7 CHAMP1 FAM13A PHF5A ZNF213 C7orf50 C17orf75 KATNB1 PMS2P3 FOXJ1 POLRMT CLCN6 CCDC92 MTX1 TRAPPC2 WDR54 IBTK DBP TTC25 PRMT5 NOLC1 MAN2C1 ILF3 HSPA14 RUVBL1 RAB11FIP4 ANKRD24 SHARPIN HSPBP1 ZBTB11-AS1 MED26 NDUFS3 THUMPD1 ST7-OT4 RHPN1 SNHG7 C9orf116 YKT6 SPAG9 KHDRBS1 DROSHA NMNAT1 TMEM203 TRAPPC2L HDAC4 SLC35E2B GGNBP1 ZNF584 TACC3 N4BP1 RFXANK MKS1 IWS1 RPS14 DNM2 RPS11 MARK4 PDXP ZNF276 MADCAM1 IMP3 TMEM144 HK1 VAMP3 SNX5 BTF3 RPL32 BCL2L2 PSMA6 FANCC PIGG PTRH1 ZDHHC3 PCED1A RPL12 REEP6 ZSCAN20 POLG AARS2 CCDC114 DCTN4 DPF2 RPA3 RPLP2 RFX1 TMEM175 NDUFS6 MTHFSD ZNF507 CHMP4B NDOR1 TRMT44 RAB11A BPTF OXCT1-AS1 DDX23 PPARD LYRM1 C9orf16 GALK2 ETF1 THBS3 ZBTB8OS ZNF689 LINC00649 SHC1 ZNF688 ALG12 PABPC1L URB1 FOXJ3 ADCK1 NAPA USP48 PSMB5 CIAPIN1 NFE2L1 SERINC5 NUP98 NAT10 MED16 CHCHD2 SAR1B KRBOX4 MAN1B1 SYT5 ZBTB40 TXNL4A CHMP2B VPS16 SNAPC2 RRP1B PRKAB1 COQ9 USE1 DCBLD1 NRF1 RBBP4 FAM102A ADARB1 MFSD5 TRAPPC13 CANT1 PIGV RAD23A SQSTM1 SH3BP5L SGTA CNIH2 RBM17 GTF2H3 BCAR3 SEC23B OXLD1 EHBP1 NDUFV1 POLR1B AAMDC DNAJC8 PITPNM1 MPDU1 OS9 POLR3D SLC37A3 COMMD1 PPP2R5E GLTP SMKR1 TOMM40 UVSSA MED18 WDR3 ZNF638 NUP50 LZIC LTBP3 DEF8 CCDC124 VPS9D1 PDE8A ACSF3 GGA1 PPP6R3 TUBB4B USP31 TRDMT1 CISD1 STOML1 KIF27 LINC00881 TMEM106B SRRD LRRC37A3 TRIM25 ZNF280D EXOSC2 LNX2 COCH DGUOK DIAPH1 NELFB PTPN23 URB2 DDX39A HNRNPUL1 RPUSD4 EAPP STK19 C2CD2L JMJD4 EIF4G1 HSDL1 DPP7 VPS4B RCOR3 ASNS GBA NUP214 SIRT6 BANP B4GALT7 MFAP1 ZNF785 SNRNP35 DCTN1 FAM83G MANBAL ALYREF XPOT TMEM59 PTOV1 RIC8A METTL9 DGKZ ZCCHC2 MAP2K5 PTCD3 BDNF-AS STIM2 CASC2 CSAD SLMAP B3GAT3 VKORC1 TIGD6 LYAR VGF HARS2 IL5 STX10 GATC TPGS1 KMT2E UBA52 TSTD2 ABCC3 AMDHD2 RBFA RCOR1 DCUN1D3 SLC39A9 PURA IMP4 TAZ ZNF484 RPS20 MON1B N6AMT1 LPCAT3 TAF3 SEC1P TOM1 NDUFAF4P1 USP21 CDK5RAP1 PRKAR2B RPL27A DHRS13 CCDC7 MSRB2 STARD3 EDF1 SLC25A25 EFHC1 PROB1 RECQL5 ABHD5 PCDH9 COQ4 PTOV1-AS1 COG1 COPS6 ATG4A BAX SCYL3 AP1G1 EXD2 NOA1 CCDC9 SH3BGR CNOT4 MIS18A ZNF341 UBTD1 FN3KRP ARHGEF12 PREPL NEURL4 MZF1 C2CD5 DCAF6 AIMP1 TTBK2 RPS26 CCDC142 CD46 ZNF778 TBP NOXA1 RANBP2 TK2 PSMC4 MRPL4 ZNF497 BRI3 CPSF4 TRMT2A RAB36 ZNF79 OFD1 SPPL3 ROMO1 VRK3 SMYD4 RMND1 DLX4 PNPLA8 ACLY P4HB BCAP29 WDR34 UBAC1 AP4E1 WAC-AS1 SMARCD1 RPA1 PIN1 RCCD1 WDR70 MTHFR RPS3A ZC3H11B MSANTD4 YIF1A RNU6-9 POLE2 SENP5 RPS7 SAMD4B CCDC57 KAT5 CSPP1 BRF2 GTF3C2 IFT172 FAM193B CDC73 SYS1 GORAB SRFBP1 GON4L TP53 PTPN18 HIRA UBC PHF6 TAB3 CBLL1 MRPS23 ZSWIM8 MIR210HG CDC42EP2 CCT7 ABCC5 THAP5 MLEC SP1 PSME3 AKT2 NCLN ANKRD40 RPL27 SRD5A1 UFC1 RBBP6 YARS2 DSN1 SRSF11 NDUFB9 CS ENSA ATR METTL17 PTDSS2 DHODH PPIG MBD1 ARFIP1 OXA1L ZNF579 MZT2B RNU6-1 POLR1D TSPAN17 EEFSEC UBAC2-AS1 MIR4258 POLD1 BRIX1 CIC EIF2D ERLIN2 SAP30BP CHD9 PPP2R1A TMEM143 SNRNP70 TOP3B IREB2 USF1 INTS10 RTN4R ATP6V1D ANP32A KCTD21-AS1 TSPAN10 PEX3 FIZ1 KRTAP5-AS1 LAMTOR4 TOP1MT LRSAM1 USP40 SNAP47 SMPD4 MED14 MED15 SYS1-DBNDD2 GTF2IRD1P1 BOK-AS1 QTRT1 UBE2Q1 PYGO2 DUS4L TCTE3 PSAT1 PPIA PACRG ZNF425 LRRC8A CSTF1 SPRYD4 CD164 PTPDC1 MTCH1 CRKL MRPL21 LEKR1 HOXC13 ARPC4-TTLL3 ITSN1 SPTLC1 SNRPC FTH1 BROX GNA12 ZZEF1 TRAK2 UBXN1 PHF7 SRD5A3-AS1 MZT2A ZNF501 SLC39A13 STX16 RNASEH2C MIPEP up
## HOXC13_TARGET_GENES 0.0012531 0.0051693 0.5525058 2.250559 0 100 LSG1 INO80 HOXB6 RHBDF1 RCC1 STK40 ERV3-1 SF3B3 COG4 MPG IL20RA SNHG3 STPG1 PPFIA3 NOP2 ZNF117 TPRXL ATP6V0D1 XPO5 CDK5 STYK1 ALG1 ZBTB45 KIAA0895L DHX38 GANC TMEM87A SART1 TTI1 TIMM9 PLAC8 KIAA0586 ABHD2 RPRD1B TJP1 OARD1 RPL32 DDR1 NFYA USP48 PPP1R13L GALNT12 up
## E2F_Q2 0.0011614 0.0051693 0.5164150 2.246940 0 168 RNF207 GNG4 UBE4B SCMH1 ZMYM4 SRRM1 SLC4A2 PUSL1 KIF1B FBXO44 YTHDF2 NCDN ZBTB48 FAM76A ARHGAP12 RCC2 ARHGEF10L PRDM16 ZNF362 AKR7L LRRC41 FBXO2 LRP8 PUM1 DDAH1 CLSTN1 PPP2R5A HPCA SZRD1 C1orf21 CMPK1 EFNA3 PDIK1L EIF2B3 RLF PKN2 KANK4 ZFYVE9 MAST2 CTNNBIP1 KCND3 B4GALT2 PIK3R3 PRPF38A MARCKSL1 ZNF32 DHCR24 CELSR2 MED8 SZT2 UBQLN4 DAP3 GNB1 VAMP3 MAN1C1 MAGI3 IPO9 RABIF EPHB2 SNRNP40 ZBTB8OS ATPAF1 YY1AP1 USP48 ATXN7L2 TRIM33 RBBP4 SLC25A16 PIGV ZCCHC17 PLK3 AGO1 SORT1 UQCRH TINAGL1 TPR H6PD PABPC4 C1orf43 SFPQ SERBP1 ADIPOR1 UROD HNRNPR MPZL1 up
## GABP_B 0.0011013 0.0051693 0.4912680 2.235743 0 249 NOC2L TBX6 EDC4 RNPS1 GTF2A2 VPS53 ASPHD1 CD2BP2 LRRC41 PPME1 SF3B3 COG4 STK35 CHERP PHLDB3 TMUB1 LSR NAA60 ZDHHC5 AGL CLMN DIS3L2 ZNF384 HERPUD2 SEZ6L2 SCAMP2 RHOT2 C9orf40 DTX2 PCGF1 CHPF LSM5 KLHL17 MAD2L1BP DDOST CLDN12 CPSF7 TAF10 KXD1 SNIP1 DNTTIP1 CELF1 PIGO CPT2 EPN1 ACIN1 FAM219A TMX1 PER2 GNB2 RANBP1 TAF5L PDZD11 ZNF485 CCZ1B FIBP NMNAT1 CCDC85B TOMM22 RAB11B TMEM208 RPL32 EBNA1BP2 PCED1A ZSCAN20 EIF1AD DDIT3 RPS6KA3 PATZ1 SUPT16H U2AF2 TRIM44 SYT5 USB1 PLA2G4D VPS16 TMEM127 PRKAB1 USE1 ZNF394 RPL34 CIAO1 UGGT2 TOMM40 LZIC CRB3 SLC38A10 SART3 SPG21 DIAPH1 UQCRH BCAT2 SF3A1 DNAI1 RSPRY1 C12orf10 CSAD B3GAT3 GALNT10 HARS2 TSTD2 MPZL3 MOCS3 MON1B NF1 TMCO1 RBM22 NUP153 TBP TRMT2A SDHAF2 ZNF79 DLX4 MYO19 LRRC29 DPM1 C14orf119 ZNF687 KAT5 RBMS2 BTBD1 PHF6 SRP54 SUPT5H MLEC PHF23 up
## ZNF711_TARGET_GENES 0.0009990 0.0051693 0.4488964 2.227514 0 1465 FBXO42 SSU72 SUN1 CDK13 TMEM248 AP001372.2 NUDCD3 ZNF12 MAGI2 ZDHHC4 AURKAIP1 E2F4 TRAF7 SRRM1 PSMC6 EDC4 EIF3B SLTM SLC35A3 MNAT1 PANK4 TAF4 OTUB1 MTOR WDR24 UBE2J2 TULP3 YTHDF2 PPP1R9A SLC7A6 ZNF398 BAD TRIP4 LSG1 URGCP MKRN3 TBRG4 SRRM2 POLD3 ZNF408 WWP2 KIAA0895 GPN2 NAPEPLD MLST8 SMARCA4 FAM76A ZNF3 LIMA1 LIPT2 AKAP1 DDX19A RCC1 STX18 POLD2 PPM1A UBE3C ANXA4 C1orf122 BMS1 ZNF362 USP54 ZKSCAN2 INTS5 TUBGCP5 CLK3 ZNF174 UBE2I CYP51A1 IPO4 ERI3 ERV3-1 MARK2 ZMYND12 CLUAP1 EPS8 ANKFY1 SLC37A1 IGHMBP2 CWC25 HMGXB3 ETFA FBXO22 SF3B3 COG4 ATP13A4 PPP1R35 ZNF496 ZNRF2P2 CREBZF INO80B WDR73 AVL9 TARDBP GNAS MGRN1 TAF6 TNRC18 SNHG3 ZNFX1 SS18L1 SLC2A4RG STK35 FAM120AOS USP42 FASTK MAP4K5 TUFM SNORA14B RILPL1 CLPX ALG10B ZXDC UBE3A NAA60 DNPEP FAM207A TSR3 ZFP64 GTPBP3 ZGPAT METTL16 ZNF592 SRCAP PAXIP1 ARHGAP1 NAE1 PHLDA3 TRMU MRPL55 SOX6 PIGQ TMEM62 HERPUD2 GPBP1L1 DDX19B SNTB2 HUS1 ZMPSTE24 SZRD1 CCDC40 SF3A2 SLC25A51 LGALS3BP CDK5 NOL9 ZNF273 KCTD5 PSMG3 TTC26 GEMIN4 CROCCP2 MST1P2 CASD1 SLC27A5 USP7 PPP4R1L MRPS15 CA13 PSMD3 RBAK ABR SRRT RNF10 MRPL48 STEAP2-AS1 RPS5 ARFGEF2 CHCHD3 PARK7 CHPF DPP3 KLHL20 MUL1 MRPS2 SPG11 SNX8 FTO TAPT1 ERI2 GPR137 ZBTB45 NCOA7 ARFRP1 RTEL1 DHRS7 CCAR2 ZSCAN32 LSM5 RLF BCKDK ZNF786 NGDN B4GALT5 TNPO3 RPTOR ZMYND8 IFT57 CHD8 NT5C3A VPS51 USP8 CCDC47 GNPTG RN7SL1 ZNF205 TRMT1 PSMA3 CPSF7 TSTA3 BRD4 COPS7B JTB BRD9 DUS1L ZBTB7A SH3YL1 PHRF1 SMG5 SMAD5 CTBP1 ANKRD11 ATP9A TM9SF1 SPG7 RANBP17 KLHDC2 RPL22 SCAF1 BOD1 LINC00552 C16orf72 HLCS PTRHD1 LRP11 TCERG1 ARID4B C1orf53 DMTN OSCP1 PYCR2 AGK SNRPB RPL29 CDCA7 NSFL1C ZNF774 GOLGB1 MGME1 CELF1 FBXO31 ZNF319 SLC2A8 TMED4 MANEAL TAF12 ANKMY1 ZFR PSMA7 GPD1L POU3F2 SNORD60 TRPM7 RNF4 SF3A3 ATG2A TIMM9 MAP2K2 HECTD1 BAG5 THAP3 RETSAT CLTA ATG14 LEMD2 DDX55 NDUFB2 CDC5L DIS3L SH2B1 ZNF32 KHNYN ESF1 KIAA0586 CPEB3 ABCB8 PI4KB RANBP1 TMEM64 PHF5A ZNF213 AKAP9 PRCC MTR C17orf75 PEX13 CPNE1 PMS2P3 TIGD1 XRRA1 TSN TRAPPC2 NBPF1 MAN2C1 SCYL1 COPB1 RUVBL1 PPP2R5B NR1H2 ZNF862 SHARPIN SLC30A5 PINK1 SFSWAP KLC2 C9orf116 AP1S1 RAD52 NMNAT1 TMEM203 HDAC4 ARHGAP21 SPATA17 TSR1 RFXANK MPLKIP GAS8 RELL2 RPS11 MARK4 NGRN STIP1 ZNF276 LAS1L MADCAM1 ATIC PPP4R1 RBM33 SNX5 RPL32 BCL2L2 RPL3 PIGG KCTD3 C11orf49 DGCR8 HSPA9 PROCA1 HSD17B12 RPL12 ZSCAN25 POLG GSAP EIF1AD PLEKHJ1 RPLP2 RFX1 AQR TSSK3 HDGF MVK BPTF DVL3 LYRM1 GOLGA3 GALK2 SMG7 BCL2L1 RNF19A NMT1 C12orf76 DHX33 FAM120A ZBTB8OS ZNF689 PAIP1 ATL1 ATPAF1 TXN2 PSPH SUPT16H CIAPIN1 SF3B2 CIZ1 NCL OGFOD3 OTUD7B CHCHD2 AFF4 PCGF3 SAR1B DHX9 ARMC10 FAM133B ZNF354B MT-TP DUSP28 ORC5 USB1 DENND6B TXNL4A ZFAS1 COMMD10 RBBP5 MAPKAPK5 COQ9 FXN MYEF2 RBBP4 UBAP2L ECE2 SMARCD2 PIGV STOML2 CDK12 SYPL1 ACBD6 RBM17 HMGCS1 BCAR3 RBM14-RBM4 ARHGEF11 RNF187 STK16 RPL9 ZC3H4 EXOC8 NDUFC2 MAP3K10 SPRTN NRDE2 DRG1 RPS23 SNX19 MIR191 LARP1B TGFBRAP1 LZIC CROT TRIM52 VPS9D1 CBX1 SON METTL15 FOXK2 NKAP GOSR1 PLEKHA8 UIMC1 ANKRD46 ACSF3 TRDMT1 BTBD10 NUP133 SLC35B3 TOMM20 MRS2 SNORD46 LINC01023 ATXN7 C16orf58 ZNF346 ZNF280D SSBP1 WDR83 NR1H3 MRPL24 GSTA4 PPCS TSEN2 DBIL5P NCK2 HNRNPUL1 EAPP JMJD4 ZER1 MTA3 EIF4G1 SAMD15 MBTPS1 ANKRA2 NUP214 HDLBP BANP B4GALT7 PSMF1 ZNF785 DTNB RRP15 PTOV1 TEX38 SURF4 PTCD3 NNT-AS1 NOSIP PARD3B TIGD6 ZC3H14 GGPS1 H6PD GTPBP10 MPHOSPH10 PTPMT1 SPIDR SEC61G DCUN1D3 SLC39A9 IMP4 YLPM1 TRAM2-AS1 RNF103 N6AMT1 TOM1 MT-ND2 MCM3AP MAML1 NDUFAF4P1 ELMOD3 CDK5RAP1 RPS27 RPL27A GPD2 NCOA5 RINT1 GPLD1 NFATC3 RPL37A TUG1 EDF1 C1orf43 GOLGA1 SLC25A25 COQ4 NUBP1 PTOV1-AS1 SEPHS1 COG1 FZD1 WDFY3-AS2 PRRG2 TESK1 DTWD2 TAS1R1 EXD2 SLC22A5 NOA1 STEAP2 WDR26 ABCC11 CNOT4 PPAN NFKBIZ MSH6 ARHGEF12 PREPL EEF1D DCAF6 TMCO1 TTBK2 ZNF805 GRSF1 PDE4A PBLD TBP NOXA1 TK2 MRPL4 RPP38 TRMT2A CERS2 SDHAF2 OFD1 ZNF460 COA3 UPF1 SLC25A36 FDPS ARID1B PNPLA8 SMG6 BCAP29 MRPL12 PUS10 C9orf163 PCNP SNRPB2 TCF12 CNIH3 ZC3H3 RBM28 RCCD1 CBLN3 TMEM209 EIF5B DTD1 PIH1D1 RPS7 ASXL1 CCDC57 PCM1 BRF2 DCAKD CDC73 EEF1B2 FBXO21 NDUFC1 RIC8B RHNO1 DICER1-AS1 DNAJC2 SETD5 HIRA NRBP1 JPX RHBDD3 CBLL1 MON1A TCF25 PRKCH AGPAT3 FBXO38 MT-TM DPY19L3 CCDC117 THAP5 C11orf74 CDIP1 ALKBH3 USP37 ANKRD40 SAE1 EFCAB7 KBTBD2 CDK4 RBBP6 SNX27 EIF2AK4 ZNF770 ZNF835 SNHG16 SRSF11 ZNF544 TBC1D16 RPL23A USP24 ING5 PDIA4 TBC1D8 DMAP1 PPIG CDK2AP1 MIR199B SERP1 LINC00535 LTBR CRTC2 ZNF579 NT5C DTWD1 GFM2 ACYP2 EEFSEC TARS2 TCTN1 FAM120B GGA2 ZNF337 RBM14 TINF2 ZNF628 GTF3C5 EIF2D STMN3 PEMT NDUFS7 SNRNP70 TOP3B IREB2 USF1 TSPAN10 PEX3 PEG10 RIOK2 CCDC88B ARHGEF7 MT-TF ZNF112 LRSAM1 USP40 SIL1 SNAP47 FOXM1 RPL14 ARHGDIA VPS54 SDE2 WDR45B GART MED15 TMEM128 GTF2IRD1P1 RNF135 UBE2Q1 DUS4L TCTE3 PSMC2 LRRC8A SRSF10 IPO7 SMURF2 OSER1 CFL1P1 MRPL21 ITSN1 ZNF714 ZZEF1 NT5DC1 FAM3A ZNF561 PRDM15 SRD5A3-AS1 CCDC97 STX16 TTC3 TUT1 NPLOC4 ENOX2 SENP6 RAD23B SLC25A11 BANF1 ZCCHC8 PDXK NIPAL2 ERGIC2 WDR43 NDUFAF3 ZNF195 KIAA1191 RRM2B TFPT POLK MAF1 TTC8 UTP3 WAC EIF2B4 CAMKMT RPL37 TSSC4 TACO1 ALG3 PSMA1 COA6 NDUFAF1 SLC5A6 FZD6 REEP5 MAPK14 ANKRD13D DHX30 ADO NAA35 TMEM9 DNM1 COX16 KIAA1549 CUL4A C1QBP AMFR PDCL3 MTX2 up
## ELF2_TARGET_GENES 0.0010070 0.0051693 0.4577426 2.226926 0 722 TYW1 SLC52A3 NUDCD3 NUTM1 KIAA0556 AAGAB SHB RPAP1 SLC35A3 CDK11B TMEM234 FAF1 GTF3C1 OTUB1 WDR24 RNF121 TELO2 TRIP4 FZR1 INO80 TBRG4 ZBTB17 ARHGAP12 FDFT1 ANXA4 CDK11A PHF14 ARID4A CD2BP2 CYP51A1 ZMYND12 PMM2 ANKRD13A PKP4 AP2B1 LRRC41 ATP13A4 EIF3I INO80B FASTKD5 IRF2BP2 STK35 UQCRC2 ZDHHC7 EVI5L ANKRD42 C15orf41 ALG10B ZDHHC5 NFATC2IP PTBP1 TERC ZNF384 ATXN2L AP3D1 DDX19B TIGD4 UQCC1 SCAMP2 UBR1 CCDC148 PSMA5 COASY RNPC3 ENO1 PHKG2 LCMT1 SLC27A5 ARFIP2 TMEM67 PPP1R12C BNIP1 SREBF2 IQCH PEX16 MUL1 UBOX5 MED19 UNC45A ZBTB45 PPP6R1 LSM5 PIGT UBE4A TNPO3 CSNK1A1 VPS51 KIAA0753 CCDC47 ODF2 LRCH4 RPS19BP1 STAMBP ELL OSBP ANKRD11 SPATS2L RNF181 SPG7 RHOQP1 AGAP2-AS1 C19orf44 RPL22 TMEM186 ZNF473 PRR14 PRMT3 SNIP1 CACTIN NOL6 LONP1 ZNF787 PPP4C RPS3 RPL29 TOX4 ZNF774 PICK1 BIN3 ZKSCAN5 VPS39 NFYC GPATCH2 CEP164 TTI1 RNF4 FDXR AP1M2 RPL18 TMX2 AP5Z1 C18orf25 CLTA CDNF EIF3D HGS SH2B1 TFIP11 STAG3L5P-PVRIG2P-PILRB RPRD1B PHF5A KIFC3 SLC25A14 NUP205 KATNB1 PMS2P3 TPRN LINC00893 HSPA14 DDX49 TMEM38A ZNF26 NSUN3 RUVBL1 HSPBP1 ACBD3 CAPN10 TXNDC12 SPATA17 LRPPRC FBXW9 RAB11B TMEM208 RPS14 PEX1 MPLKIP TXNDC17 DNM2 TRMT6 RN7SL2 RPL32 PTRH1 GATAD1 DDX56 ZSCAN25 UTP18 ZNF107 RPLP2 AQR COX14 CHMP4B AC092118.1 ATP13A1 RPS15 RPL11 ZNF317 BTF3L4 C12orf76 MRPL54 GTPBP4 ZNF688 AATF SIK3 RIN1 U2AF2 ZNF343 SF3B2 CSNK1G1 CHCHD2 NVL ELOF1 MAN1B1 SMARCC2 RBBP5 PRKAB1 GHDC USE1 ZNF394 FIS1 SH3D19 RPL34 UBAP2L HECTD4 STIL CDK12 VPS25 GTF2H3 MALSU1 SEC23B EXOC8 GMPPA SPRTN OS9 TOMM40 MYO9B TMEM260 CRB3 METTL1 RABGEF1 GGA1 SLC38A10 HAUS8 SSBP1 WDR83 RPS29 EXOC4 SCP2 AAR2 TMEM183A DGUOK SLBP TCP11L2 DPM3 PPCS ZNF684 DIAPH1 DDX39A UQCRH VPS4B NUP214 CCDC61 TBC1D22A MFAP1 NAA25 DDX28 UBXN6 RAB27A PTCD3 KTI12 RAB2B ARL16 STX10 GTPBP10 POLR2F SIGMAR1 MRPL51 MOCS3 SLC39A9 MON1B ADAM9 RPL38 SEC16B RPS27 RPL27A C1orf43 ZNF277 NUBP1 MCM3 RPL19 SCYL3 RNH1 NOA1 FBXO24 TMEM9B RAB11B-AS1 MZF1 DCAF6 AIMP1 TIMM10 ZNF460 RPIA VRK3 KLHL26 COX8A RMND1 ZNF217 FDPS LRRC28 DUS2 LRRC29 WDR34 SNRPB2 NDC1 DPM1 RCCD1 BLOC1S3 INCENP RPS7 YWHAE TMEM230 PCM1 GTF3C2 MCM8 SLC35C1 SYS1 GON4L TTC23 TAB3 MRPS23 CCT5 DDX42 TFCP2 MLEC PHF23 PSME3 NCLN RRP12 RPL27 up
## FXR1_TARGET_GENES 0.0010030 0.0051693 0.4528242 2.224916 0 1002 KIF16B DNAJC11 ATAD3B NOP9 TBX6 ADCY9 C16orf91 PEX10 ZNF462 FAM118B DNAJA3 RER1 CASZ1 TRNAU1AP RNF40 SLC9A2 PUSL1 PGBD2 PAQR4 SLC35A3 LIF SNRNP25 TAF4 METRN ZNF609 SESN2 POLR3K FAAH KIAA1522 GTF2A2 NUMA1 SMURF1 SPRED2 TAOK2 TMEM201 ASPHD1 NOM1 ZNF3 MTFR1L SUSD4 RCC1 MAD1L1 UBE3C MPI CDK11A ZNF768 SIN3A COG7 CLK3 CXorf56 FEM1A DDRGK1 CLUAP1 INPPL1 PPP1R37 IGHMBP2 CWC25 LRRC73 VPS4A HMGXB3 RNF32 SLX4IP ARX ZNRF2P2 DAGLA WDR73 EXOSC6 RAI14 ANKRD54 SS18L1 STUB1 CAPN15 PPFIA3 PHLDB3 NOP2 SNORA14B ZNF764 FRMD5 PLS1 TRMT61A LSR TSEN54 NAA60 LSM14B KPTN AMH RPL13 ARFGAP1 TSR3 ZGPAT PHF12 CDR2 NADSYN1 SRCAP ABCB9 HAGH MORN1 ATXN2L CRK PIGQ SNTB2 SEZ6L2 CASC4 ARID1A PACS2 RHOT2 C1GALT1 SLC25A22 PRDX5 KCTD5 GEMIN4 SIGIRR AIFM1 WDR87 CMTR1 INTS4 SRRT TACC1 ADAT1 INPP5K DAB2IP DHCR7 BPNT1 RPS5 DBNDD2 ARFGEF2 LAMTOR1 SREBF2 NEIL1 GRWD1 ALG1 SNAPC5 FOXA3 ENTPD6 MVP FBRS UNC45A ZBTB45 ARFRP1 PPP6R1 CCAR2 LINC00630 LSM5 WDR55 DZANK1 RPTOR NOP14-AS1 FARP2 FAM50A CHD8 LAMA5 DHPS SLCO4A1 GNPTG CD151 CD55 SIPA1L3 XXYLT1 TJP3 B4GALT2 PLLP LRRC14 KDM1A NELFA SH3BGRL2 CDC42BPB CAAP1 DEAF1 HOOK2 SUSD2 ZNF839 TRIP6 PRR7 KLHDC2 PAQR6 MADD TAF10 ZNF473 MRPL28 VEZF1 PPP4C SLC35B2 AGK MNT NSFL1C TRABD TNPO2 ATXN10 POLDIP3 PIGO SART1 VPS39 SLC35B1 TAF12 SPEF1 RNF114 PSMA7 SGMS1 EPN1 TXNDC16 SF3A3 TULP4 MRPS26 KANSL3 GDI1 DNAH2 BAG5 THAP3 AKAP8 ATG14 ANAPC2 GMEB2 PCYT2 DDX55 ACIN1 CHMP6 ZNF692 RPL36 LRRC1 CPEB3 MLX DBNL ZNF213 NDUFA4 PARP12 ATG9A SGSM3 TPRN FAHD1 MTX1 XRRA1 TSN DBP NOLC1 C1orf109 LINC01006 GRHL1 CITED1 COPB1 ARHGAP44 SHARPIN MED26 PRKAR1B RFFL LZTR1 MXRA7 FBXW9 RRP7A DHRS1 LRRFIP2 TMEM144 TRMT112 GTF2H2C ELMO3 MTHFS UBTF DDX56 PCED1A AARS2 RABIF POLR2C MAMSTR MLPH DDIT3 RABGAP1 COQ7 RAB11A MFSD10 BPTF NMT1 SRRM5 THBS3 PNKP GTPBP4 PAIP1 ATPAF1 HNRNPAB TXN2 CNIH4 RIN1 EBF4 MARVELD2 CAPN12 MRPL11 TSTD1 OGFOD3 ANKDD1B PPP1R13L POMT2 ATMIN FAM133B CORO2A IRF7 ALDOC PRKCA DENND6B ZFAS1 VPS16 EIF3G POMZP3 MYLK3 SMARCD2 PIGV MRPS11 MAP3K11 KCNC3 CNIH2 EHMT1 SRM SUMF2 ZC3H4 ATXN7L3 MAZ PLAC9 AHCTF1 TRIP11 PLK1 ZBTB42 SNX19 TMEM179B LTBP3 METTL15 NKAP PLEKHA8 GDF9 PDE8A XYLT2 CISD1 STRN4 TOMM20 GPR35 WDR83 RPS29 PFDN2 ABCA7 PPIL2 AAR2 SLBP PAWR ZFAND2B DBIL5P B3GNT8 RPUSD4 TCIRG1 JMJD4 KMT2D GBA SH3GL1 RARA B4GALT7 ECE1 RRP15 PTOV1 TEX38 NRG4 PDAP1 RREB1 C12orf10 RAB27A POMGNT2 TIGD6 GATC AMDHD2 HYI MDFI CDKN2AIPNL ADAM9 SSNA1 USP3 EFNA4 SEC1P ANKZF1 RALGDS DHRS13 NFATC3 PKMYT1 CCNF PCDH9 PCK2 PTOV1-AS1 SEPHS1 SCYL3 AP1G1 IFT122 ZNF211 MAP4K2 PAM MIS18A RTBDN HMGB3P22 TNFRSF19 TIMM13 ALKBH5 HAX1 FAM131A RPS6KL1 LRRC46 DPCD SLC50A1 VRK3 COX8A UCK1 SYTL1 NSUN7 ARID1B CTXN1 PLCH1 MRPL12 C9orf163 AP4E1 CDC37L1 CYTH2 ZC3H3 RBM28 C8orf76 BICD2 WDR70 UBR3 DTD1 RPS7 RPL36AL AVIL BRF2 POLR2J4 MUC1 FAM193B NDUFC1 GPBAR1 HIRA SEC24C UBC TMEM168 CYC1 FKBP2 ZNF576 ZSWIM8 DPY19L3 C11orf74 ALKBH3 FKRP SSBP2 SAE1 F11R MRPS27 ZNF544 PTDSS2 ZNF77 SUPV3L1 DMAP1 SLC1A5 TRIM47 MRPL10 IMPDH1 EPS15 WDR4 CRTC2 ZNF579 AC007389.1 MAML3 AFF1 RNU6-1 MICA ELK1 BRAP ATP8B3 POLD1 DGAT1 WDR5B CIC GTF3C5 EIF2D TOR4A TYSND1 TOP3B USF1 INTS10 TSPAN10 PAXBP1 TAF2 FOXP1 DPM2 HDDC3 SNAP47 FOXM1 ZNRF3-AS1 ARHGDIA NUP85 ZHX1 MFSD3 SNX16 IL10RB PYGO2 NHEJ1 CHCHD1 CCND1 RHOF METTL2B WWP1 CASKIN2 MRPL21 SNRPC MLLT3 STX6 CLDN7 TBC1D10A KAZALD1 PRDM15 SMYD3 TP53TG5 up
## RBM34_TARGET_GENES 0.0010050 0.0051693 0.4518866 2.214726 0 846 PDXDC1 SUN1 FIBCD1 PDP1 AP001372.2 SCMH1 JMJD8 MRPL20 PTPRA AURKAIP1 HMOX2 RER1 SOX8 B3GALT6 EDC4 RFX2 SLC35A3 E4F1 PANK4 CABIN1 KIF1B TTLL12 ACSS2 RNPS1 NBPF3 SLC7A6 ZNF398 ASL KIAA1522 MBOAT1 EHD4 SRRM2 POLD3 FLYWCH2 KIAA0895 C16orf70 PRSS27 MTFMT IDH3A LRWD1 MYO6 USP39 ADRM1 CDON LIPT2 MGAT4B POLD2 UBE3C CCNL2 GFER CTTN RPUSD1 TRIM7 SDF4 TUBGCP5 ZNF174 NMRAL1 AHDC1 CHGB PIEZO1 PUM1 AVL9 CAPN1 LRRC45 HOXC-AS1 PPFIA3 FASTK MVD DECR2 TOR1B PKM TIRAP VAPB TP73-AS1 FAM207A MIB2 ARFGAP1 FHL2 ZFP64 EMC8 PAXIP1 ADAM15 TRMU MORN1 PPP2R5A ADAMTSL5 SAV1 AP3D1 PANK2 LMF1 ERF RRBP1 RAB11FIP1 CDS1 EZR APRT TMEM259 PPP4R1L TMEM189 PDXDC2P PLCG1 WIZ STK11 ANXA11 PSMD11 CHTF18 DHCR7 DBNDD2 SVIL NME4 RUNDC1 WRNIP1 TUBB2A EPS8L2 PARK7 PGAP2 DNAJC5 MRPS2 GALNS CDHR2 TNIP2 HABP4 SPATA2L CCAR2 ZSCAN32 LSM5 BCKDK ZNF786 FARP2 CD55 DNMT1 KRI1 TEF BRD7 PLLP GALNT18 WFS1 NELFA ZNF212 PHRF1 ANKRD11 MYH14 SNAPC4 MAD2L2 RAB40C SPG7 SF1 TMEM177 WDTC1 PRMT3 TUBG1 LONP1 IMMT PPP4C CDCA7 BRSK2 NSFL1C ZNF774 HADH SPRED1 FOXJ2 TRIM45 SLC2A8 ACTN4 CNNM3 MOCOS LARP4B C1orf216 SBNO2 GAK GPSM2 C19orf73 GMEB2 DDX55 SLC7A5P1 MKRN1 TFAP2A RPL36 PHYH YRDC MACF1 ZBTB21 RANBP1 CTBP2 CLCN7 RMND5B NAMPT NAA40 SGSM3 RPL35 YIPF2 DBP MAN2C1 SPIRE2 GATAD2A CTSH KCNK5 RAB22A TRIM28 MIOS BHLHE40 C9orf116 SEMA4F NAT9 FANCA TRAPPC2L LMNA TACC3 CLN6 TADA2B LRRFIP2 ZNF276 ATIC RBM33 DGCR8 MTHFS PROCA1 CCDC114 SOX12 RPLP2 MKNK2 TMEM175 FBXL16 ALKBH4 FRMD8 HMG20B SLC25A10 PPARD FGFRL1 RN7SL525P BCL2L1 ANKRD16 SPECC1L-ADORA2A ANK1 ASH1L USP48 SF3B2 CAPN12 CIZ1 NUP98 GPR3 PPM1H OGFOD3 POMT2 CHPF2 FHDC1 AFF4 POLE4 LRRC59 IRF7 DENND6B SNAPC2 NEK9 GIGYF2 ACTR3C SLC25A13 PRKDC PDLIM2 SQSTM1 ERICH1 ABCB10 MAP3K10 CIB2 TXNDC11 RAB40B HIBADH DRG1 ZNF638 VPS9D1 FOXK2 POLA1 SLC38A10 PDCD6 QSOX1 ACOT7 TUBB4B SLC35C2 USP20 TMEM106B WDR83 C2orf68 SPPL2B PPARA HNRNPUL1 TCIRG1 ZER1 MBTPS1 MTMR3 PITRM1 ALYREF GORASP1 SMARCB1 RIC8A NNT-AS1 FANCE SURF2 E2F1 POMGNT2 ATG4D NUDT1 ZC3H14 NLRX1 C21orf58 DPP9 SLC12A9 PURA TSPAN12 MARK3 C2CD2 TAZ CDKN2AIPNL RNF103 SEC1P ZNF782 LINC00482 PLOD1 NF2 RALGDS TMEM39B NFATC3 HTT ACADS PKMYT1 EDF1 SLC25A43 WDR62 SPIRE1 CAMK2G ABHD5 SLC8A2 NEK7 TMEM9B SMYD5 ARHGEF12 NETO2 TMCO1 BMP8B ZNF778 FAM131A KIF1C TTC19 STXBP1 DAG1 BRI3 RPP38 GLRX3 TRMT2A CERS2 PCNT SMYD4 UCK1 TSC22D2 ETFB MPZL1 UNKL P4HB COX4I1 RPA1 PIN1 RCCD1 BICD2 FADS3 SENP5 CAPRIN1 SAMD4B CCDC57 SUCO FBXO21 OPTN SETD5 PTPN18 HIRA BTBD1 MON1A TCF25 SCARB2 AGPAT3 CDC42EP2 XYLB STRIP2 RCAN3 EFR3A FZD5 CATSPER2P1 CNOT11 SMAP1 EIF2AK4 GORASP2 ME2 PLEKHF1 C11orf91 IER5L TUBB4A ZNF77 PDIA4 TBC1D8 SLC1A5 NDUFAF6 NOD1 APOO IMPDH1 ZNF558 KDM4B TDH EEFSEC ZSWIM7 ZNF18 GGA2 P4HA2 up
## HOXB4_TARGET_GENES 0.0010000 0.0051693 0.4496743 2.210892 0 980 SLC9A4 PDXDC1 KIAA0319L LINC00265 SLC52A3 HNF4A GET4 TBX6 GSPT1 TP53BP1 HMOX2 DDI2 PUSL1 SLTM SLC35A3 ANK3 WRAP73 PHF13 E4F1 GSE1 ZNF629 HSD17B6 RPPH1 TULP3 ZNF398 SLC2A13 STAU1 NADK TRIP4 MCAT EHD4 ZNF777 POLR1C NCDN TJP2 CLTB CDCA7L NFAT5 SERTAD4-AS1 MRPS34 CLRN3 ASPHD1 EDC3 MGAT4B TTC22 ARID4A MNX1 MLXIP PTPN12 USP54 SIN3A ERI1 NMRAL1 STK40 ZMYND12 PKP4 PPP1R37 USP2 SH2D3A ETFA TRIT1 FBXO22 ZNF598 FAM214A STAP2 ARHGEF19 CYP4F12 METTL3 AVL9 TAF6 ANKRD54 STPG1 ECI1 ANKS3 FAM120AOS FASTK MVD PEX14 PLS1 PKM HOXC-AS2 LINC00511 CHMP4C ZDHHC5 TSR3 GTPBP3 SAYSD1 EME2 TRMU PPP2R5A ATXN2L TMEM62 TIMM44 KRT8 SEZ6L2 XPO5 GOLPH3 PANK2 LMF1 KCTD14 MAPK8IP3 C1GALT1 CCDC148 TTC26 MRPL49 CROCCP2 TRADD TMEM126B MST1P2 ELOVL1 VILL FAM220A RNF216 STEAP2-AS1 DHCR7 SREBF2 IQCH DPP3 PNPT1 EPHB3 ERI2 XAB2 ZBTB45 DFFA NCOA7 RTEL1 LSM5 NUDC KIAA0895L DDX41 MAP7 IL23A FBXL12 NLE1 MACC1 SCAMP4 RPLP1 TTC31 GANC TRPC4AP DDX31 B4GALT2 LRCH4 KDM1A LCLAT1 DEAF1 OSBP L3MBTL2 TRIP6 NET1 RAB40C TM9SF1 FBXL8 ACAP3 TUBGCP6 ZNF473 GCC1 SYNJ1 TUBG1 TRMT12 IMMT LRBA TRIM56 PPP1R14B PYCR2 PARP2 BRSK2 PLEKHA6 CDPF1 TNPO2 GBA2 POLDIP3 FAU SART1 ZC2HC1C MTHFD1L RNPEP TRPM7 AP1M2 ATG2A GATA6-AS1 HECTD1 BAG5 ZNHIT1 MIR320A CCDC24 RETSAT B3GALNT2 LEMD2 MKRN1 RBM47 DDX27 TPD52L2 LRRC1 STAG3L5P-PVRIG2P-PILRB PLOD3 NAMPT C7orf50 FARSA ETNK1 TMEM65 KANK1 DBP C4orf47 GATAD2A ILF3 MAPK8IP2 PPP2R5B PDE4C FAM221A BHLHE40 YKT6 CEP70 SPAG9 STK25 MPND FBXW11 HDAC4 ZNF584 CD320 SCAI EPDR1 OARD1 NR2C1 LRRFIP2 PPP4R1 RBM33 PGAM5 TMEM30A POLG SMOX AARS2 CCDC114 SNRNP40 TMEM52 ZNF608 RFX1 MRPL37 HDGF GATA6 NUP88 RPS15 LYRM1 GOLGA3 SMG7 RNF19A C12orf76 AJUBA PNKP ADAT3 LMLN PAN2 AATF SNX13 RIN1 CIAPIN1 MARVELD2 RAB27B NAT10 ILVBL POMT2 HACE1 DUT IGSF9 CHCHD2 AFF4 NRL ARMC10 FAM133B SLC25A39 RTEL1-TNFRSF6B DUSP28 GPATCH8 ZNF335 NEK9 COQ9 ACTR3C FIS1 PTPN13 HECTD4 STX4 SMARCD2 SQSTM1 MRPS11 STOML2 DIP2B EHMT1 GTF2H3 CTDSPL2 RAB35 MORN2 RPL9 NDUFV1 ZDHHC12 AHCTF1 POLR1B TRIP11 CCDC107 ACKR2 ZCCHC17 POLR3D R3HDM4 YAP1 SNHG8 ANKHD1-EIF4EBP3 LRIG2 MIR191 PLK3 MYO9B ANKHD1 TRIM52 RPS8 GOSR1 GDF9 UIMC1 PDE8A SLC35B3 MRS2 ATP8B1 HAUS8 ZNF346 NASP SART3 YIPF3 SCP2 C3orf52 PPIL2 RBBP9 ZWINT PPCS ZNF684 LRRC49 C2CD2L GTF3C4 EIF4G1 ASNS NUP214 BANP HK2 TBC1D22A PPA1 SMAD7 RRP15 MAP2K5 CSAD SURF2 LIMCH1 VKORC1 RAVER1 RPS27A C21orf58 GOLGA5 COX7A2L DPP9 DCUN1D3 SLC12A9 SLC39A9 PURA NWD1 RPS20 N6AMT1 LPCAT3 EFNA4 SEC1P ZMAT5 MAML1 ELMOD3 TMEM39B TMOD3 STARD3 HSP90AB1 ABHD5 COQ4 BCL3 BARHL1 FZD1 WDFY3-AS2 AASDH TESK1 RNH1 EXD2 STEAP2 WDR26 SNORA65 CRAT FBXO24 HMGB3P22 HOTTIP TTBK2 RBM22 CCDC142 ABLIM2 TBP NOXA1 TK2 LIG1 RPS6KL1 ZNF497 PCNT SLC50A1 SPPL3 FIGNL1 VRK3 RPS4X FDPS IVD UNKL AMER1 ADAL OSBPL10 WDR34 WAC-AS1 MPV17L2 C14orf119 ZNF687 IFIH1 UQCRQ SAMD4B TST STYX MUC1 CDC73 WDR27 WDFY3 TYMS TAF1B SETD5 ZNF131 LTK AGPAT3 MMACHC TFCP2 IGF2BP3 XYLB ABCC5 ZNF860 ANKRD40 SAE1 RPL27 STAT2 HOXA13 EFCAB7 NDUFA2 SNX27 SOCS2-AS1 EIF2AK4 YARS2 SRSF11 MRPS27 CS MEF2D DMAP1 NOD1 RCN1 WDR4 KDM3A ATP8B3 EEFSEC MATR3 C16orf71 DGAT1 ALKBH2 CIC ERLIN2 STMN3 SHISA5 PIBF1 SNRNP70 CHID1 USF1 ATP6V1D up
## MYC_Q2 0.0011574 0.0051693 0.5006621 2.198382 0 178 MAEL UBR4 FGF6 NRIP3 NR0B2 OPRD1 ATAD3B TDRD1 ATAD3A CNNM1 B3GALT6 COL2A1 LHX9 SLC25A33 EPB41 MRTO4 SC5D RCOR2 USP2 LRP8 EMC1 PTPRF BCL9L HPCA ADK UBXN10 MACROD1 UBIAD1 CGN RUSC1 AK2 NUDC RLF B4GALT2 RAB3IL1 WEE1 RPL22 ACAP3 PLEKHA6 ESRRA CNST IPO13 WDR77 VWA2 POLR2L CTBP2 AMPD2 TFB2M SCYL1 PFKFB3 HOXC12 TXNDC12 EBNA1BP2 HPCAL4 TSSK3 FOXJ3 FOSL1 NAT10 ATXN7L2 PPRC1 PITX3 TSKU RRP8 E2F8 HOXC11 TGFB2 POGK PFDN2 RPUSD4 C2CD2L PLA2G4A up
## ATOH1_TARGET_GENES 0.0011429 0.0051693 0.4956146 2.197574 0 194 C16orf91 TRAPPC3 PANK4 TBL3 TELO2 STAU1 NFAT5 NTHL1 FBXL19 FEM1A PPP1R37 GLOD4 GUSB SETD1A PHF12 TSC2 CHD2 CASC4 CLPB C9orf135 KCTD5 CROCCP2 NOP14 ABCF2 MST1P2 SLC27A5 MRPS15 PPP1R12C CHCHD3 FOXA3 DFFA CCAR2 FAF2 TIPIN AUP1 GUCD1 ZNF354A TIMM22 COPS7B SNRPD3 NELFA ZNF749 SCAF1 BOD1 PSMC3 MGME1 SART1 MAP2K1 SF3A3 TIMM9 RPL36 KIAA0586 PRCC C17orf75 BRPF1 C1orf109 PSMD12 SHARPIN NDUFS3 SFSWAP CTDP1 FBXW9 SNX5 HDGF CHMP4B HNRNPAB USP48 PPRC1 SAR1B ZNF354B TMEM127 UGT8 WNK1 CIAO1 COMMD1 MED18 METTL15 MRPL24 GBA BANP SNRNP35 KAT6A EXD2 SRGAP1 NUP153 CMSS1 C19orf53 ZNF444 NDC1 ARF6 RPS7 ASXL1 ZNF131 HARBI1 MMACHC CCDC117 PTDSS2 COMMD7 CEP350 DTWD1 ATG13 ZNF337 up
## ZMYM2_TARGET_GENES 0.0012285 0.0051693 0.5273499 2.192537 0 115 GET4 EIF4G3 GDF15 ADRM1 ICMT RN7SL3 ZNHIT2 RCOR2 MARK2 VEPH1 NR6A1 STK35 MLLT1 CREBBP LINC00337 SERINC2 BCAR1 SKI RAC1 WRNIP1 FAF2 TJP3 PPP4C PPP1R14B MIDN CHMP6 AHCY CDH3 DAP3 PDE4C SHARPIN DOT1L RPS14 RFX1 DAP RNF19A YY1AP1 PPP1R13L PCGF3 SMARCD2 ZC3H4 HIBADH MYO9B HAUS8 NEMF SAMD15 TDRD7 RAC3 GALNT10 NLRX1 PBX1 RPL28 EEF1D PDE4A ERCC4 TMCO3 TST ARGLU1 MPST RBFOX2 SAE1 EPB41L4A-AS1 TIGD5 RNU6-1 CMC2 CSRP1 BRAP STEAP1B PPIA RPF2 LFNG AP2A2 MAF1 CD3EAP MTA2 PFAS PPIC CENPN BRWD1 up
## NPAT_TARGET_GENES 0.0011325 0.0051693 0.4897293 2.185013 0 204 AP001372.2 ZNF12 DNAJA3 TOLLIP-AS1 RFX2 FADD POLD3 ZBTB17 MLST8 SMARCA4 LIPT2 NPRL3 MOK SNORA14B VAPB ZDHHC5 SAYSD1 PHF12 ATP6V0E2-AS1 SNX1 CROCCP2 MST1P2 FAM220A IQCC ENTPD6 FBRS PPP6R1 CSNK1A1 VPS51 SMG5 SMAD5 ATP6V0E2 ZNF473 LONP1 CEP250 DAGLB RPL36 KIF3B RANBP1 NUP93 RRP1 NBPF1 ANKRD24 SIN3B KHDRBS1 PRELID2 CD320 BLOC1S4 ARMC6 DPF2 SRRM5 NVL MAN1B1 ZBTB40 MCRS1 GLG1 CDK12 RBM17 EHMT1 RAB35 EXOC8 FAM222B TOLLIP SPRTN SUGP2 ZNF106 CISD1 TOMM20 SPPL2B JMJD4 EMC10 THAP7 CDC42EP4 SIRT6 HINT1 PITPNB RPRD2 SEC61G N6AMT1 CCDC7 CHCHD4 MIS18A HMGB3P22 TIMM13 TK2 RPP38 TRMT2A VRK3 RMND1 AP4E1 PAGR1 THAP7-AS1 SAMD1 ZNF576 MTCH2 PHF23 RPL27 FAM71E1 KDM3A FAM122A FXR2 SNAP47 RNF19B ANKRD26 SRSF10 WWP1 POLA2 MRPL45P2 CCDC12 WDR43 TFPT CHD1 up
## SMARCA1_TARGET_GENES 0.0012594 0.0051693 0.5343589 2.178832 0 104 ADAP1 TTC39A RNF121 IDH3A PRKAA1 ARID4A RPUSD1 MAP3K6 FAM66B ALG10B CUX1 TADA2A CHTF18 TACC1 TOB2 MAP7 NGDN NAALADL2 VEZT ZNF664 DUSP14 OR2A1-AS1 MT-ND4L FGD6 SHARPIN RHPN1 KLC2 DNM2 STIP1 MT-ND5 RFX1 KANSL1-AS1 PPARD ORC5 TRIM21 EPHB4 EHMT1 MT-ND4 UIMC1 ACSF3 TUBB4B FEM1B VGLL4 BMPR1A HERC5 COG1 MAP4K2 LRGUK KLHL12 COL3A1 P4HB DDB1 up
## KLF13_TARGET_GENES 0.0009990 0.0051693 0.4359031 2.169559 0 1766 GNG4 KIAA0319L ISG15 KIF16B DNAJC11 SLC9A1 GET4 MUTYH ATAD3B THRAP3 NOP9 TBX6 ATAD3A PEX10 GSPT1 TTC39A TP53BP1 AURKAIP1 CARHSP1 AAGAB DYNC2H1 SMIM1 CDHR1 SLC4A2 EDC4 PER3 PUSL1 MECR PGBD2 PELI2 WRAP73 PHF13 CTU2 METRN RNF121 BSDC1 ZNF629 HSD17B6 VWA1 DHDDS PDE11A TELO2 ASL NR1D1 TRIP4 FZR1 LSG1 EXPH5 ZNF408 GPN2 RHBDF1 NAPEPLD NCDN AXIN1 TXLNA CLTB PRPF6 IDH3A MRPS34 HMGA1 USP39 PEF1 CHMP1A PRKAA1 SMARCA4 TMEM201 CES2 TMEM222 UCKL1 EDC3 ZNF3 LIMA1 MTFR1L C16orf46 NXN STX18 UBE3C POLR3E PMS2 LMBR1 GBAP1 EEF2K MLXIP LIG3 ZKSCAN2 TPRG1L ERI1 CLK3 HDAC1 ZNF174 UBE2I SPATA33 CYP51A1 IPO4 CLCNKB FBXL19 DCUN1D5 MARK2 FOXO6 CLUAP1 CHGB INPPL1 MICU1 PPP1R37 MAP3K6 C1orf159 SH2D3A LRRC41 PMEPA1 FBXO22 ZNF598 BLCAP ATP13A4 HES4 MORC2 PPP1R35 PIEZO1 GLOD4 ZNRF2P2 GNE INO80B EIF6 TAF6 ANKRD36C ZNFX1 REV1 LRRC45 STUB1 CAPN15 DLG3 PPFIA3 KIAA2013 ANKS3 CENPT CHERP TUFM LRP2BP EPB41L4B TRIP10 EVI5L TOR1B FRMD5 ESYT2 CLPX TSEN54 PAFAH2 TMEM159 UBE3A EFCAB14 NAA60 LSM14B KPTN RRN3 CGB7 TSR3 SMG1 ZC3H18 PHF12 MRPS6 NSUN4 PTBP1 NYAP1 SRCAP ARHGAP1 NAE1 CSNK1G2 ADAM15 ZNF384 LUC7L HAGH MRPL55 LETM1 ADAMTSL5 GAS5 ATXN2L LINC00115 AIMP2 EARS2 AP3D1 KRT8 ATP6V0D1 HPCA GPBP1L1 ADK HPS4 HUS1 ZMPSTE24 CASC4 AGRN KMT2C CLPB ARID1A SF3A2 NOL9 MAPK8IP3 PRDX5 KCTD5 PSMG3 NUP160 ABCF2 ADNP2 DSTN VPS37B PRMT1 APRT AHCYL1 PPP4R1L WDR87 GFPT1 CMTR1 EYA3 PIAS4 C1QL1 CDC14B INPP5K DHCR7 BPNT1 TERF2 RUNDC1 TUBB2A IQCH EPS8L2 CHPF POLR3B FOXL1 C15orf61 DNAJC5 C1orf35 XPO6 EFNA3 SNAPC5 TMEM219 USP10 CLNS1A ZNRF3 SNRNP200 TNIP2 DFFA PDIK1L RNF24 NCOA7 PPP6R1 CCAR2 CLDN6 ZNF646 ZSCAN32 TIPIN BCKDK UBA1 ZNF354A SCAPER NELFCD FBXL12 NT5C3A MTMR12 NLE1 CCDC47 TIMM22 GNPTG RND2 CPSF7 SCAMP4 SIPA1L3 ZNF76 SGSM2 GANC TJP3 DDX31 COPS7B PLLP PTGES2 SAMD10 LRRC14 CDAN1 TTLL11 GALNT11 BRD9 KDM1A KCNH2 PHRF1 SDHA ZNF839 VEZT WDR59 MAD2L2 ZDHHC9 WEE1 FBXL8 RPL22 ACAP3 SCAF1 TUBGCP6 ZNF473 UBE2H GCC1 BOD1 ZNF239 UBFD1 TRMT12 ZNF787 NAPB PPP1R14B GRIN1 AGK AP4M1 EMC9 MNT BRAT1 VAC14 TMEM87A CREB3L1 MIER2 NSFL1C ATXN2 ETV3 CELF1 SPRED1 FBXO31 ANKS1A RABEP2 MIDN CCDC137 SART1 MAP2K1 ZNF500 NIPA2 MTHFD1L CNNM3 PPIL6 SF3A3 KANSL3 PRAME TMEM134 MAP2K2 BAG5 LRRC8B ZNF703 PDP2 TMEM150A B3GALNT2 CCDC136 SPOCD1 POLE AKAP8 LEMD2 DDX55 HMGCL WDR77 BTBD9 TIGD2 SH2B1 MAPK6 RPL36 PAK4 RAB4A FGD6 RANBP1 CTBP2 AMPD2 TAF5L CHKA HNRNPLL CCDC127 SEMA4B RRP1 MXRA8 C17orf75 PARP12 NPHS1 RPL35 FAHD1 SUPT6H BRPF1 TSN NBPF1 NOLC1 SCYL1 TSC22D4 KLF16 ILF3 PFKFB3 HIVEP3 RUVBL1 NR1H2 PDE4C TRAF4 ANKRD24 HSPBP1 NDUFS3 PRKAR1B PINK1 TIPARP KLC2 SIN3B SNHG7 AGO3 NAT9 KHDRBS1 NMNAT1 LMNA HDAC4 CAPN10 TXNDC12 GNB1 SLC35E2B PRELID2 CHAC1 TSR1 APLP2 RFXANK FOXN4 MPLKIP PXN DHRS1 NR2C1 NGRN GIPR LRRFIP2 ZNF276 MADCAM1 ATIC USP35 ZMYM1 SLC27A1 TRMT112 FANCC EBNA1BP2 DGCR8 CKB MTHFS WDR47 HSPA9 ZDHHC3 EIF1AD UTP18 CCDC114 PLEKHJ1 TMEM52 PELP1 MKNK2 HMG20B PSMB10 CHMP4B RHOBTB3 GATA6 SIK2 SNHG11 RAB11A PISD RPS15 BPTF PPARD SLC12A7 GOLGA3 NEK8 CBX4 ISOC1 SMG7 ERGIC3 MYH9 BTF3L4 ANKRD16 NMT1 ZNRF2 C12orf76 AJUBA SLC39A11 PNKP PLCE1 ZNF689 NEURL3 ADAT3 TLCD1 PATZ1 URB1 ATXN1L FOSL1 CAMSAP1 CIZ1 CPAMD8 NCL ILVBL PPP1R13L HACE1 CLASRP DUT MED16 PXMP2 IGSF9 HEXIM1 HSBP1 FAM133B SLC25A39 RTEL1-TNFRSF6B C2orf50 AACS PI4KA ZBTB40 TXNL4A MCRS1 ZFAS1 PHKA2 ZNF335 RAPGEF3 RRP1B RBBP5 FBXW8 VAMP8 HECTD4 STX4 C1QL4 RRP8 RAD23A MAP3K11 SYPL1 DIP2B VPS25 PCOLCE-AS1 DPH1 SOWAHA NDUFV1 ZBTB42 UBALD1 CCDC107 CIB2 SUGP2 ZNF668 OS9 RPL23AP53 TEAD1 YAP1 PLK3 MYO9B ARHGAP33 AGO1 LZIC VPS18 VPS9D1 RPS8 TCEA2 METTL15 YWHAG ANKRD46 ACSF3 ZNF784 CAMTA1 GGA1 ANKRD37 POLA1 TIPRL ACOT7 TUBB4B MORF4L2 TRDMT1 KLHL36 BTBD10 SNORD46 STOML1 USP20 SQLE HAUS8 LINC00881 SRRD LRRC37A3 KCTD21 ZNF280D TMEM125 HEATR1 SLC35F5 PFDN2 LRP6 SPPL2B SPG21 DIAPH1 BFSP1 NELFB SMPD2 PTPN23 URB2 HNRNPUL1 UQCRH BCAT2 FAM98C GTF3C4 JMJD4 ZER1 ARHGEF18 ASNS ANKRA2 GBA SIRT6 SUMO3 MAN2A2 AUNIP PSMF1 NPW DDX54 ALYREF COX10-AS1 DRAP1 TMEM191A RRP15 PTOV1 ULBP1 SURF4 METTL9 VGLL4 ZCCHC2 MAP2K5 PRKCZ ATAD2 NOSIP B3GAT3 LYAR CSNK1D VGF ARV1 FLCN H6PD KMT2E UBA52 GTPBP10 C21orf58 MPHOSPH10 RCOR1 DPP9 SLC12A9 BPHL RNF170 DAZAP1 FAM185A NR1D2 RALGDS DHRS13 ATP8B2 CCDC7 UBE2L3 HTT ACADS CCNF ARHGAP40 KDM6B PCDH9 SLC8A2 COL1A1 NUBP1 AGO2 SEPHS1 FZD1 SERBP1 COPS6 FHAD1 KRT18 SLC39A3 ZFP62 PRRG2 TESK1 RNH1 TAS1R1 EXD2 KLF13 CHCHD4 CNOT4 ZNF596 BTBD19 SMYD5 DNAJC1 MSH6 CAMKK1 PRRC1 NEURL4 C2CD5 EEF1D TTBK2 ZNF805 CD46 PBLD HAX1 NUP153 FAM131A CMSS1 TSC1 NOXA1 TK2 EVI5 IFT52 LIG1 TSPAN9 ZNF497 TRMT2A PCNT SDHAF2 TSGA10 SPPL3 ZFPL1 BCL7C ROMO1 VRK3 TFAP4 RMND1 IST1 HNRNPR NDUFA10 HLTF ARID1B UNKL ADAMTS14 WDR34 UBAC1 C9orf163 CECR2 ZBTB12 TCF12 UBE3D RBM28 MFSD12 RPS3A GSTM3 TLR5 FADS3 RNU6-9 UBR3 DTD1 LINC00896 RPS7 SAMD4B GOLGA2 NCOA3 PAK1IP1 CSPP1 DCAKD WDR27 G0S2 UAP1 DNAJC2 SAMD1 HIRA CA5BP1 JPX SRP54 LTK MON1A MMACHC RPL5 KDM4A-AS1 LSM10 ATRN XYLB ZNF414 DHX34 CDK5RAP3 RAD54L EFR3A ALKBH3 ANKRD40 RBFOX2 TMEM245 MYL6B KIAA1841 TMEM102 KEAP1 EFCAB7 KBTBD2 CDK4 SNX27 CYP2E1 DYNLT1 EPB41L4A-AS1 ASPH RPL23A MEF2D PTDSS2 TIGD5 WDYHV1 TAF6L DMAP1 NDUFAF6 AP3M2 SLC48A1 RPL23 MAML3 PLCH2 SFT2D2 DTWD1 TTC13 ELK1 EEFSEC TCTN1 CHCHD6 C16orf71 GGA2 POLD1 DGCR6L DHX35 CIC ZNF628 EIF2D ERLIN2 STEAP1B STMN3 ITGB1BP1 PEMT KCTD9 TOR4A TOP3B PDPR CHID1 TNFRSF21 TSPAN10 CCDC91 PEX3 ZNF652 PHF20 TOP1MT SNAP47 NIT1 ABLIM3 SBF2 ZHX1 MFSD3 RAD51B ITPKA PPARG GTF2IRD1P1 DDIT4 MINK1 MAPKAPK3 UBE2Q1 PSMC2 EXOC5 LRRC8A SPRYD4 METTL2B MTCH1 SRSF10 ELOVL4 COX7C RAB24 ASCC1 PAFAH1B3 CASKIN2 TIMM50 CFL1P1 HNRNPF MSTO1 SPTLC1 BROX SCAP PDZD8 FANCG up
## ZSCAN30_TARGET_GENES 0.0010000 0.0051693 0.4355313 2.161340 0 1482 DHRS3 RERE NAV2 VPS13D PDXDC1 KIAA0319L SLC12A2 FER1L6-AS1 DNAJC11 SLC9A1 NOC2L UBE4B ADCY9 BAIAP2L1 PEX10 EFR3B THSD4 JMJD8 ZDHHC4 SRCIN1 AURKAIP1 CARHSP1 DIDO1 SLC1A1 DDI2 PGP AKR7A2 SMAD3 IFI6 EDC4 NME3 PAQR4 SLC35A3 ANK3 CTU2 CABIN1 TBL3 GSE1 ZNF609 WDR24 MSANTD2 UBE2J2 ZNF629 ARHGEF28 FAAH TELO2 ZNF398 YTHDF1 UXS1 TRIP4 FADD LSG1 BCOR SRRM2 VSTM2L RHBDF1 RHPN2 TPPP SPRED2 NCDN PRSS27 CLTB MTFMT CLUH EPB41 NFAT5 VKORC1L1 MRPS34 THAP10 FBXO34 USP39 NOM1 TMEM222 ARHGAP12 UCKL1 HOXB3 SNHG12 STX18 PPM1A NTHL1 JAKMIP2 LMBR1 BMS1 GFER ADPRHL2 EEF2K MLXIP ZKSCAN2 BDKRB2 RPUSD1 ERI1 CLK3 SYNJ2 GAN UBE2I RCOR2 HOXB9 PAXIP1-AS1 INPPL1 PPP1R37 IGHMBP2 VPS4A SPATA20 FBXO22 ZNF598 CAPN2 ATP13A4 MAPK8IP1 PIEZO1 ZNRF2P2 RHCE CT62 EXOSC6 MYO5B TNRC6A STUB1 ANKS3 GUSB FASTK MAP4K5 SLC25A29 DECR2 NEO1 NCAPH2 NOC4L EPB41L4B CFDP1 INTS1 REXO1 FRMD5 SKIDA1 PKM MYOM3 EFCAB14 LSM14B L2HGDH CUX1 TM7SF3 FAM207A MIB2 RRN3 FHL2 GTPBP3 XIST ZGPAT MRPS6 SIX1 NYAP1 PAXIP1 EME2 NAE1 CSNK1G2 PHLDA3 NTN3 TMC7 LMF2 LUC7L ADAMTSL5 TSC2 ATXN2L SAV1 CRK NDUFB10 HERPUD2 ZNF783 KRT8 CCDC159 ZMPSTE24 KMT2C LEPR CLPB ARID1A BCL7A RHOT2 SLC25A51 NOL9 BCAR1 MTUS1 OTUD3 PSMG3 RAB11FIP5 SLC20A2 TRADD VPS37B EZR AFG3L1P GFPT1 TFDP1 PLCG1 CGN MIR193A AUTS2 ANKS1B ANXA11 CHTF18 FGF9 DBNDD2 WRNIP1 SREBF2 ASB6 SLC45A3 ALG1 DNAJC5 USP10 AGAP3 CISD3 TOB2 FBRS TNIP2 RNF24 ARFRP1 DHRS7 APP PPP6R1 CCAR2 ZBTB7C NDUFAB1 RUSC1 RBPMS MTF1 ITPR3 ZNF786 PKN2 KLHL17 TNPO3 PCGF2 RSPH3 ZFYVE9 VPS51 STRADB DDX51 CD55 ZNF205 ARRDC1 TSTA3 XXYLT1 ZNF76 TJP3 TRPC4AP FOXB1 KCNC4 COPS7B ANKLE2 PTGES2 DUS1L RSAD1 SH3BGRL2 PHRF1 SMAD5 ZNF839 CTBP1 CLCN2 NET1 ASS1 TOM1L2 RANBP17 EGFEM1P UBE2H OTUB2 TARBP1 C16orf72 EIF2B5 EPCAM VANGL1 SLC35B2 RPS3 CDT1 AGK OCRL MNT OSBP2 PLEKHG5 MIER2 NSFL1C ETV3 FOXC1 EP400 CELSR1 PIGO ZC3H12A MANEAL ZDHHC1 HIVEP2 TMEM132B MTHFD1L PPIL6 RNPEP SLC39A14 CDK10 TRIM67 TXNDC16 SF3A3 TPD52L1 MSH3 TATDN1 PPM1L THAP3 CTCF TMEM150A SLC35G1 POLE ATG14 LEMD2 SMAD6 DDX55 STRIP1 CLPTM1L MKRN1 ACIN1 TFAP2A CENPBD1 SMYD2 MACF1 GNB2 TRIM3 ZBTB21 CTBP2 CLCN7 ARF1 FAM193A RMND5B C7orf50 ZNF236 RRP1 C17orf75 PAK6 PARP12 TDRP TIGD1 CKAP4 HINT3 YIPF2 C12orf49 GNG12-AS1 PTAR1 PFKFB3 SYDE2 CCDC88C MGAT5B ZNF704 MAPK8IP2 CERS6 SEMA3C ARHGAP44 MIOS TIPARP RFFL MAGEF1 RAD52 RNF11 NMNAT1 PITHD1 CBFB DLC1 MXRA7 SLC35E2B TACC3 CLN6 ALDH7A1 ARFGAP3 GAS8 MARK4 ERC1 SALL1 ZNF276 ATIC LGR5 GK5 EXO5 SAMD11 DGCR8 UBTF NOP56 WDR47 PCED1A ZSCAN25 AARS2 TRIM24 ELAVL1 ZNF608 POLR2C MKNK2 AIG1 CDC20B TSSK3 HDGF PTK7 SIK2 RAB11A ENC1 BPTF SLC25A10 DDX23 SORBS3 SLC12A7 GOLGA3 CBX4 ISOC1 ANKRD16 ZNRF2 DLST SLC39A11 ATL1 SCAND1 ATPAF1 TRIM11 FOSL1 MARVELD2 CIZ1 RNF217 DNAJC6 IDH1-AS1 OGFOD3 OTUD7B PXMP2 ARMC10 YY1 FAM133B C4orf36 BRD3 ELOVL6 TP53I11 TXNL4A INPP5A VPS16 RAPGEF3 SBF2-AS1 SMARCC2 RRP1B RBBP5 PRKAB1 FXN PTPN13 NRF1 EIF3G MAPK4 SMARCD2 FOXRED2 SQSTM1 ADAR WNK1 MMP15 MYOF VPS25 BCAR3 MFSD6 KCTD8 ARHGEF11 MAZ POLR1B NDUFC2 COG2 TXNDC11 CYB5R3 TEAD1 SLC37A3 COMMD1 YAP1 SNX19 SMKR1 LARP1B BTG3 PPP1R13B ZNF503-AS2 LZIC LTBP3 DEF8 VPS9D1 IFFO2 METTL15 FOXK2 YWHAG PDE8A NCOA2 PPP6R3 LRRC37B TRDMT1 STOML1 ROM1 C16orf58 LRRC37A3 MSX1 ANO8 NRXN2 DESI2 KCTD7 SLC2A1-AS1 SLBP LRP6 PITPNC1 ZNF264 PRDM10 CH25H ROGDI NELFB AP5S1 SRPK2 SMPD2 LRRC49 JMJD4 ZER1 RCOR3 CDC42EP4 CCT6B TTC7A SH3GL1 MAN2A2 B4GALT7 PSMF1 LOXL1-AS1 NPW DTNB SMAD7 DRAP1 RRP15 PTOV1 TEX38 ULBP1 METTL9 TDRD7 ZCCHC2 BMPR1A BDNF-AS STIM2 GRAMD1C LIMCH1 GCSH GATC H6PD TSTD2 SGMS2 PBX1 RBFA RCOR1 DPP9 SLC12A9 FAM66C FGFR1 KAT6A DPY19L1 TRAM2-AS1 CDKN2AIPNL RNF170 JUND MCM3AP CDK5RAP1 SELENBP1 PTGFRN DHRS13 CCDC7 NCOA5 GPLD1 NFATC3 PKMYT1 PDGFA PITPNA SARS2 SEC16A CAMK2G MNS1 PTOV1-AS1 SEPHS1 BARHL1 FZD1 FHAD1 WDFY3-AS2 HMG20A SLC39A3 ZFP62 TAS1R1 EXD2 ISM1 CHCHD4 ADIPOR1 PON2 PDS5A PAM STK3 NFKBIZ SNHG17 COMTD1 ARHGEF12 EEF1D RPS26 BMP8B PBLD KIF1C NOXA1 EFNB1 MRPL4 ANKRD20A4 TFAP4 INPP1 HNRNPR TSC22D2 HLTF BCAP29 MRPL12 WDR34 USP25 C9orf163 C12orf65 AP4E1 TSHZ1 RGMB-AS1 RCCD1 DLX6 FADS3 TMCO3 PRICKLE2 SENP5 RPS7 CAPRIN1 SAMD4B CCDC57 ICK CSPP1 BOLA3 ADAMTS3 ITGB5 BRF2 DDX11L5 ILDR2 GFRA3 JUP TYMS DICER1-AS1 DNAJC2 PTPN18 ZNF131 BTBD1 JPX UBC RHBDD3 HARBI1 MON1A SCARB2 DYRK1A IRS4 ACACB CCDC102A IGF2BP3 ABCC5 INPP4B LINC01033 FZD5 CDIP1 ALKBH3 AKT2 NAA30 PPP3CA ANKRD40 SSBP2 GPRC5B PPP1R3B SOCS2-AS1 FAXC ZNF770 DDX11L10 P4HA1 CDK17 NDUFB9 ATR PDIA4 DMAP1 MYO1B AP3M2 TRIM47 LINC00327 RCN1 SERP1 IMPDH1 ALDH1L1 ZNF579 MZT2B AC007389.1 MAML3 AFF1 ATG13 GFM2 EEFSEC TARS2 CHCHD6 PARM1 C16orf71 up
## GRHL1_TARGET_GENES 0.0010000 0.0051693 0.4361007 2.161119 0 1334 MYBPC1 KIAA0319L UBR4 SLC52A3 SLC9A1 SHROOM3 ZSWIM5 UBE4B C16orf91 MYO1A PTPRA DAAM1 AURKAIP1 C1orf174 SCUBE2 RNF40 SRRM1 ANKRD6 SLC35A3 ANK3 FAF1 KAZN TBL3 GTF3C1 MYO10 RNF121 PLA2G4B ZNF629 TULP3 SLC7A6 STARD10 ARHGAP32 TRIP4 GTF2A2 SRRM2 SYTL5 TRIM2 ZNF408 FNBP4 PRKCE KIAA0895 SPRED2 NCDN TJP2 FAN1 NIPAL1 ZBTB17 PACSIN2 CCDC86 PACSIN3 RBCK1 PEF1 ARHGAP12 BRAF LIMA1 AKAP1 SPATA2 NXN ZNF830 ANXA4 PMS2 PHF14 ZNHIT2 NIP7 BMS1 FARSB EEF2K SIN3A CD2BP2 STK40 FBXL19 FEM1A MARK2 PMM2 EPS8 TRAK1 SH2D3A CIB1 STAP2 BLCAP IYD VPS41 SDHB CREBZF CNNM4 NGEF MYO5B GGCT STPG1 IQCK MOK SRC CCNK MAP4K5 NOP2 CFDP1 ZNF764 IPP ALG8 C15orf41 PKM PAFAH2 LINC00511 SETD1A FRMD4B CHMP4C ZDHHC5 PHF12 PTBP1 SUCLG1 ARHGAP1 ZNF384 EPN3 DHX29 PEX11A GAS5 LRRC57 AIMP2 TMEM62 KRT8 ATP6V0D1 CHD2 CCDC159 HUS1 DPH2 ZMPSTE24 UQCC1 LINC00339 ISG20L2 PLXNB2 MACROD1 IQCD PSMG4 PSMA5 PRDX5 DCTPP1 COASY STX3 ZSWIM1 CDS1 LURAP1L CASD1 TMEM259 AIFM1 RAB25 C1orf21 CGN INTS4 RNF216P1 FAM220A RNF216 RNF10 RBBP8NL MRPL48 DAB2IP RSBN1L RPS5 TERF2 CEP170B IQCH NEIL1 PARK7 RPL24 POLR3B PNPT1 SNAPC5 SRI MED19 SLC16A13 CISD3 UFSP1 RRNAD1 CLNS1A ZHX2 MCCC1 FBRS JKAMP ZBTB7C FAF2 UBA1 CEP85 UBE4A DZANK1 NAALADL2 RPTOR NELFCD IL23A ZMYND8 FBXL12 NT5C3A CSNK1A1 BLZF1 ARRDC1 CTNNBIP1 SMC5 RPLP1 TTC31 TRMT11 GANC TCF7L2 ESRP2 SNRPD3 RPS19BP1 ERP27 OVOL2 TMTC2 SH3BGRL2 UBN2 NCEH1 ZNF823 OSBP L3MBTL2 RNF181 KRIT1 NME7 SF1 RPL22 TMEM186 ZNF473 CACTIN C16orf72 KCNV1 EIF2B5 ARID4B IMMT PCF11 PTPN14 RPL29 VAC14 TMEM87A SPTLC3 EHF MGME1 POLDIP3 ZNF319 SART1 ZKSCAN5 VPS39 SLC35B1 ZDHHC1 NFYC GPATCH2 ANKMY1 TTI1 FDXR IPO13 TMX2 SETD3 CRYM-AS1 B3GALNT2 GDPGP1 ABHD17C CAB39L FUCA1 ZNF692 ESF1 BCL6 MACF1 ABCB8 STAG3L5P-PVRIG2P-PILRB PAK4 MED8 RPL13A RPRD1B AKAP9 SZT2 KIFC3 ULBP3 NDUFA4 SEMA4B PEX13 SFI1 TSN NBPF1 TTC25 C12orf49 BDH1 C1orf109 TMEM38A SEMA3C NR1H2 PDE4C TRAF4 KRT19 THUMPD1 ERAL1 RAD52 FBXW11 CBFB SPATA17 RANGAP1 LRPPRC ALDH7A1 RAB11B NIPA1 RPS14 PEX1 OARD1 NR2C1 RNF126 STX19 TPCN1 TRMT112 FMN1 SNX5 DDR1 EBNA1BP2 PIGG NCOR2 L3HYPDH TMEM30A EIF2B2 EIF1AD RPA3 RFX1 CASC1 AC092118.1 RAB11A ATP13A1 PISD RPL11 LINC00543 PPARD LYRM1 TUBB2B NMT1 C12orf76 SRRM5 WWTR1-AS1 MRPL54 ARL6 AJUBA LCA5 ZBTB8OS ZNF689 LINC00649 ATL1 ASH1L NFYA SCAND1 NDUFB7 PAN2 TLCD1 URB1 PSPH USP48 PSMB5 LCMT2 NCL MRPL11 OGFOD3 ALCAM PPRC1 KRT80 DUT WDR78 IGSF9 WDR93 ELOF1 USB1 ERBB3 TTC17 SMARCC2 RBBP5 NFIA NEK9 GHDC USE1 POP7 RPL34 RBBP4 RPS15A C1orf226 SMARCD2 SQSTM1 MAP3K11 KCNC3 ACBD6 GTF2H3 BCAR3 PELI3 SEC23B WSB2 MORN2 RPL9 EHBP1 EXOC8 FAM222B SPRTN PTPRG CCDC151 PPP2R5E RNU4-2 TOMM40 PCNA MUC13 WDR3 SON GOSR1 GDF9 POU2F3 MRPS33 NCOA2 MRS2 PIK3C2A EXOSC2 WDR83 SART3 EXOC4 PPIL2 TOMM7 PAWR NLGN2 DDX39A LRRC49 ISL2 ROCK2 NEMF KMT2D THAP7 CCT6B THRB HDLBP BANP TBC1D22A PTCH1 RRS1 ZCCHC2 C12orf10 MLF2 STIM2 RPL31 GRAMD1C RALY EGF NOSIP FAM126A COA1 IL5 RPS27A GGPS1 PKP2 FAM185BP SOX2-OT ABCC3 GOLGA5 SEC61G SLC12A9 MOCS3 SLC39A9 ZBTB43 ZNF484 RPS20 MON1B ADAM9 FAM185A SEC16B EBAG9 RPL27A CFLAR CCDC146 RPL37A WDR62 UTRN EFHC1 CLASP1 RECQL5 ABHD5 RPS9 SLC3A2 BCL3 MCM3 DNAL1 FZD1 SERBP1 SCYL3 AP1G1 AASDH THOC2 CCDC9 RNVU1-6 ZNF138 BTBD19 PIP5K1B PSMC3IP BZW2 RAB11B-AS1 NEURL4 RPS26 CCDC142 HAX1 APOL2 CMSS1 TBP WDR20 AK7 DAG1 PSMC4 RPP38 VRK3 KLHL26 PRKCSH TAF1A ETFB SLC25A36 ACLY AMER1 MCCC2 ADAL PHB SNRPB2 NDC1 FRRS1 MPV17L2 DPM1 PLEKHG3 ZC3H3 RCCD1 RPS3A PARD3 MSANTD4 CBLN3 UQCRQ RPL7L1P8 PAK1IP1 PCM1 ITGB5 DCAKD SUCO SYS1 EEF1B2 NDUFC1 GORAB JUP THAP7-AS1 MRPL32 UAP1 SIDT1 DNAJC2 SEC24C ZNF131 TAB3 PMPCB RHBDD3 SRP54 CYC1 ZNF576 NEDD4L SUPT5H FBXO38 SNUPN SP8 GEMIN6 C11orf74 CDK5RAP3 RAD54L PSME3 USP37 AKT2 PPP3CA SAE1 MYL6B STAT2 GPATCH3 THRB-AS1 UFC1 EFCAB7 NDUFA2 ZNF770 MRPS27 CS ENSA METTL17 POU6F1 SUPV3L1 SLC1A5 PIWIL2 ZNF655 PPIG SERP1 TTC30A LTBR STK11IP BRAP ZRANB2 ZSWIM7 TARS2 EIF3J WDR5B BRIX1 ITGB8 EIF2D SAP30BP MCTP2 up
## HNRNPUL1_TARGET_GENES 0.0009990 0.0051693 0.4360686 2.160220 0 1274 GALE VPS13D PDXDC1 RNF207 TRNP1 KIF16B HNF4A SLC9A1 GET4 MUTYH MAPKBP1 UBE4B ATAD3A NPSR1-AS1 MRPL20 SRCIN1 PTPRA AURKAIP1 DIDO1 AAGAB TRNAU1AP SMAD3 IQCE MFN2 EDC4 SLTM EEPD1 LMTK2 FAF1 KIF1B ZNF609 TTLL12 SESN2 ACSS2 TF SCARNA2 ARHGEF28 FAAH YTHDF2 ZNF398 BAD PPFIA1 CLCC1 FAN1 PRSS27 TXLNA CLUH NFAT5 LRWD1 MRPS34 HMGA1 LRRC47 MRTO4 ZC3H7A ADRM1 SMARCA4 TMEM222 ARHGAP12 WDR90 SNHG12 SHH RCC1 STX18 CC2D1B ZNHIT2 CCNL2 GFER NUTF2 ADPRHL2 RNU4-1 ERI1 CLK3 GAN DGAT2 CYP51A1 MAP3K9 EPS8 GID8 ANKFY1 ZBED4 LRRC41 FBXO22 APOB THAP4 PIEZO1 GLOD4 DAGLA GNE AVL9 MIR3180-4 ZNFX1 SLC2A4RG EMC1 IRF2BP2 TNRC6A ECI1 CENPT MIR429 USP42 NUDT22 FASTK DECR2 NOC4L SLC7A6OS SLC22A23 VSIG10 TRPT1 SKIDA1 SUPT3H PKM RTKN LSM14B SETD1A FAM207A RPL13 MIB2 ARFGAP1 TSR3 ZFP64 ZGPAT ZC3H18 PLAGL2 EMC8 EME2 NAE1 ATP6V0E2-AS1 ZNF384 LUC7L TRMU ATXN2L HERPUD2 SNTB2 CHD2 HUS1 AGRN KMT2C ARID1A ERF BCAR1 MACROD1 PSMG4 PSMG3 LAD1 PTPRK ENO1 CROCCP2 GLIS2 MST1P2 CMTR1 PLCG1 CGN PSMD3 ANXA11 SRRT WASL PSMD11 PRMT7 ARFGEF2 TUBB2A IQCH AKIRIN1 PRTG DNAJC5 PKD1P6 MRPS2 SNAPC5 GALNS SRI FOXA3 PRR5-ARHGAP8 CISD3 TOB2 GPR137 PDIK1L NCOA7 ARFRP1 RTEL1 APP B4GALT6 LSM5 AUP1 XRN2 THOP1 PHKB MSH4 ZFYVE9 CSNK1A1 NLE1 GNPTG DDX51 RMDN3 KRI1 SCAMP4 ZNF76 TRPC4AP COPS7B RELA RN7SL296P ANKEF1 DUS1L RSAD1 CREB3 SMAD5 PRR7 CAST SF1 SSR4P1 ATP6V0E2 SCAF1 WDTC1 TUBG1 C16orf72 HLCS LONP1 ZNF787 EPCAM NAPB SLC35B2 HM13-AS1 AP4M1 OSBP2 RAB43 RPL18A NSFL1C TRAF3IP1 ZFYVE28 MGME1 SPRED1 TINAG FBXO31 POLDIP3 ZC3H12A MAP2K1 NFYC ANKMY1 HNF4G SGMS1 NIT2 S100PBP SLC39A14 EPN1 FDXR KANSL3 RPL18 RPSA HECTD1 IPO13 MARCKSL1 WDR25 C18orf25 GPSM2 UBE2M HSD17B2 ANAPC2 SREK1 MAPK6 MYH10 COX19 PHYH LRRC1 SRPK1 GNB2 ATG16L1 PAK4 TAF5L CLCN7 CHAMP1 DBNL SPR CPB2 KIFC3 SEMA4B RRP1 LRP10 TPRN TIGD1 GATAD2A SYDE2 RMND5A CERS6 RABGGTA PSMD12 CNKSR3 SHARPIN TRIM28 KLC2 BHLHE40 SNHG7 C9orf116 ARFGAP2 YKT6 CHAF1B AP1S1 STK25 KHDRBS1 FANCA LZTR1 NMNAT1 LRRC61 TRAPPC2L PRELID2 CD320 TOMM22 RFXANK TJP1 MEPCE MARK4 ZNF276 MADCAM1 SNX5 GK5 RPL3 FANCC MTHFS RUSC2 PGAM5 NOP56 NEAT1 POLG FAT1 SOX12 ALKBH4 DLG4 SIK2 RPS15 ENC1 BPTF LYRM1 RN7SL525P CBX4 BCL2L1 TUBB2B ZNRF2 B3GNTL1 NEURL3 ADAT3 PAIP1 ASH1L HNRNPAB TLCD1 NCAPD2P1 FOXJ3 ADCK1 NFE2L1 OTUD7B HACE1 FAM133B GADD45GIP1 LRRC59 RTEL1-TNFRSF6B MKLN1 FUS ANKS4B PIWIL4 INPP5A SNAPC2 FBXW8 FXN ACTR3C PRKDC SLC25A16 TAF1D ADARB1 RRP8 ECE2 SMARCD2 RAD23A PTK2 GTF2H3 ABCB10 RPL9 MAFF AHCTF1 IDUA NDUFC2 ZFAND6 UBALD1 HIBADH MIR3131 FAM222A COMMD1 YAP1 MYO9B MSL1 NUP50 LZIC DNAJC9-AS1 TCEA2 FOXK2 PLEKHA8 RN7SL132P NPAS1 CRB3 PDE8A ACSF3 PPP6R3 ZNF48 STOML1 USP20 HAUS8 ATXN7 C16orf58 GJB1 TMEM106B ZNF280D SYNE1 DESI2 STRN HPCAL1 SPON2 DIAPH1 DNAJB2 URB2 GPCPD1 HNRNPUL1 UQCRH FAM98C ROCK2 JMJD4 ZER1 ARHGEF18 MBTPS1 THAP7 CDC42EP4 ASNS GADD45A ATF7IP2 PSMF1 ECE1 MANBAL ATP1A1 ALYREF SMAD7 XPOT DRAP1 METTL9 TDRD7 PITPNB RREB1 MLF2 CCDC34 SURF2 B3GAT3 CSNK1D NUDT1 H6PD RASSF7 C21orf58 GOLGA5 ENOPH1 BPHL KAT6A MARK3 ISOC2 RPS20 CDKN2AIPNL KIF13A GAS2L1 SSNA1 USP3 JUND NR1D2 CDK5RAP1 C5 NFATC3 STARD3 EDF1 PITPNA PCBD1 TRIB2 HSP90AB1 WDR62 DMTF1 UTRN CLASP1 PCK2 SAFB2 COG1 KLF13 VASN PDS5A ZNF341 NFKBIZ UBE2V2 ARHGEF12 C2CD5 EEF1D EIF3M CPPED1 FAM131A KIF1C NOXA1 MRPL4 RPP38 CPSF4 PMPCA RAB36 PCNT CHDH IST1 ARID1B ACLY BACE1 MRPL12 DDB1 DGKQ COX4I1 TCF12 PLEKHG3 UBE3D ZC3H3 C8orf76 TYMP MFSD12 TMCO3 SENP5 ASXL1 NCOA3 CCDC57 SLC34A1 CSPP1 POLR2J4 CDC73 GSDMD THAP7-AS1 RHNO1 DICER1-AS1 SETD5 HIRA RDH14 GRB7 BTBD1 JPX HARBI1 CA8 TCF25 SIRT7 TAB1 DYRK1A FBF1 ATRN IGF2BP3 GOLT1A FZD5 CDIP1 CATSPER2P1 RRP12 CNOT11 KEAP1 RBBP6 SRSF9 SLC37A4 P4HA1 EPB41L5 SERPINA4 USP24 TIGD5 TBC1D8 MYO1B OMA1 CRTC2 MZT2B AC007389.1 MAML3 DTWD1 ATG13 ELK1 ACYP2 EEFSEC FAM120B CLCN5 SNRPA DGAT1 ZNF337 DHX35 EIF2D STMN3 NUP188 NDUFS7 SNRNP70 TOP3B MOSPD3 INTS10 TSPAN10 CCDC91 PEX3 FOXP1 PPP2R2D ZNF652 JUNB ARHGEF7 RBMX F11 SNAP47 RNF19B SMPD4 OCEL1 MFSD3 WDR45B MED15 KLHL7 MINK1 UBE2Q1 DUS4L TCTE3 ZNF425 MTTP LRRC8A LLGL2 KIFC2 METAP1D C16orf95 APOH STX6 SCAP FAM162A KAZALD1 LATS2 MZT2A SLC39A13 STX16 TRAPPC9 NPLOC4 CCDC12 RASSF3 RAD23B ARRDC2 ERN1 MCM7 FBXO36 ATG4B TRIP12 DCXR PSMD13 USP27X RNVU1-14 ZNF232 PRR5 ELAC2 TBC1D14 RAF1 CFH MAF1 STARD9 SAFB EIF2B4 ARID2 CTTNBP2 ZMYM3 PPP1R15B PPP1R3C MST1L ALG3 DDX20 NRP1 AMACR DPP4 up
## ZNF524_TARGET_GENES 0.0010776 0.0051693 0.4683280 2.156611 0 295 RERE NOC2L DNM3 TMEM248 AURKAIP1 SLC4A2 B3GALT6 PGBD2 MYO1C WDR24 RNPS1 INO80 SRRM2 PRKAA1 CDON ZNF3 POLR3E BMS1 ZKSCAN2 SDF4 ANKRD13A C1orf159 SBK1 GLOD4 NR2F6 GNAS FRMD4B MIB2 EPHA2 LUC7L TLE3 ARID1A ELOVL7 KCTD5 SALL2 RNF31 SLC27A5 FOXL1 C1orf35 MRPS2 PLCD3 RTEL1 IL23A ZNF205 TM9SF4 GANC ESRP2 COPS7B KDM1A DUS1L NELFA PIK3R3 AGAP2-AS1 RPL29 TMEM87A NSFL1C ATXN2 ZDHHC1 SGMS1 SF3A3 ATG2A IFNLR1 DDX55 TFAP2A GNB2 AKAP9 C17orf75 PFKFB3 PPP2R5B MED26 C9orf116 AGO3 MED25 EXOC7 ZNF276 VPS37C FANCC C11orf49 NOP56 RFX1 MVK RPL11 SMG7 ZNRF2 DPYSL5 AJUBA TSHZ2 PAN2 FOXJ3 HEXIM1 LRRC59 RTEL1-TNFRSF6B ZBTB40 PSME2 FBXW8 MAP3K5 SMARCD2 C4orf48 SOX13 NDUFC2 MAP3K10 CCDC107 ACKR2 PLK3 CCDC124 VPS9D1 PLEKHA8 PDE8A TMEM183A FBRSL1 DIAPH1 ZNF34 NEMF JMJD4 EMC10 GBA SSBP3 DRAP1 PTOV1 RIC8A PNPLA3 KMT2E NLRX1 BET1L PCDH9 NUBP1 PTOV1-AS1 HMG20A SLC39A3 UBTD1 ARHGEF12 PBLD NOXA1 TSPAN9 MRPL4 SPPL3 ARMC4 NDUFA10 C12orf65 BRF2 NDUFC1 CD2AP JPX EFCAB7 ENSA ING5 DMAP1 FAM71E1 MAML3 GTF3C5 EIF2D STMN3 R3HCC1 NDUFS7 TOP3B BRMS1L HDDC3 MMAB SNAP47 OCEL1 up
## U2AF2_TARGET_GENES 0.0010010 0.0051693 0.4370377 2.147303 0 944 DHRS3 SPEN UBE4B KIAA0556 TP53BP1 AAGAB DYNC2H1 TRAF7 IQCE EIF3B OASL NOX5 TMEM234 EIF4G3 E4F1 ZNF609 GTF3C1 OTUB1 MSANTD2 DHDDS GDF15 BAD TRIP4 GDE1 FZR1 LHX9 ZDHHC11 NUMA1 WWP2 POLR1C SPRED2 C16orf70 THAP10 GCAT C16orf46 BMS1 GFER TMEM231 USP54 ZKSCAN2 INTS5 IPO4 CYSTM1 BTBD3 PMM2 FOXO6 RANBP10 ANKFY1 IFT140 C1orf159 USP2 TRIT1 GMDS SLX4IP SF3B3 CCDC130 COG4 ATP13A4 THAP4 DAGLA EIF3I CNNM4 PUM1 WDR73 DHRS2 EXOSC6 TAF6 STPG1 STK33 TNRC6A IQCK KIAA2013 ANKS3 SPATA6 KIAA1671 DECR2 RALGAPA1 ANKRD42 NFATC4 SNX25 ALG10B PAFAH2 MYOM3 PES1 ARFGAP1 ZFP64 PIFO NYAP1 CSNK1G2 PEX11A ATXN2L KRT8 GPBP1L1 C6orf132 TIGD4 HUS1 CASC4 ARID1A LONP2 SPAG16 ANO5 ERF CTU1 OTUD3 GSG1L LRTOMT ZSWIM1 UBE2O LDLR MRPS15 GTF2I SPICE1 ABAT MYO9A CAMK2D RAC1 IQCC ADAT1 ENTPD5 POFUT2 RUNDC1 CHCHD3 IQCH ZNF827 PRLR PRTG GALNS C7orf57 FTO ENTPD6 TOB2 XAB2 GPR137 TNIP2 PPP6R1 LRRC56 TYRO3 AK2 RLF GUCD1 XRN2 PCGF2 RPTOR CCDC113 DHPS NRSN2 KIAA0753 NEK4P1 RND2 AGTRAP ZNF76 HRAS TCF7L2 MIR3189 COPS7B SNRPD3 ODF2 PIK3R3 ZNF839 SNAPC4 NET1 GEMIN8 C19orf44 TMEM186 WDTC1 LRRC6 DNTTIP1 VEZF1 OSCP1 C20orf96 PCSK4 AP4M1 MNT TRAF3IP1 PICK1 TNPO2 BAZ1A POLDIP3 ZDHHC1 COMMD4 SNORD60 SF3A3 KANSL3 DNAH2 LONRF1 TATDN1 DNAH7 TBC1D9B GPSM2 CLTA RHPN1-AS1 SREK1 RBM47 ESF1 RPL36 RPS12 RSPH1 ATG16L1 PAK4 TBC1D32 AMPD2 NAMPT KIFC3 SLC25A14 C7orf50 MT1E UBQLN4 FOXJ1 POLRMT CLCN6 TCTN2 ZNF142 WDR54 PRMT5 ILF3 ANO3 KIAA1211L NDUFS3 PFKL RHPN1 CEP112 YKT6 AP1S1 TRAPPC2L HDAC4 KNOP1 ZNF584 KIAA1614 TADA2B TOMM22 TXNDC17 BCL2L2 FANCC EBNA1BP2 C11orf49 ZNF324B TMEM8B NEAT1 RPL12 REEP6 EIF2B2 PYCR1 ZBTB7B RFX1 GCC2 MAPRE3 SENP8 CASC1 DLG4 CC2D2A HMG20B ATP13A1 BPTF RPL11 SMG7 PARN CA11 NMT1 ARL6 AJUBA MAGI1 HNRNPAB PATZ1 FOXJ3 SIK3 U2AF2 FAM20B NUP98 PPM1H WDR93 NRL ARMC10 CXXC1 C2orf50 MAN1B1 SYT5 FUS SCARNA16 ZNF335 GHDC C20orf27 PTPN13 RPL34 UBAP2L TRAPPC13 PLEKHB1 DDB2 SMARCD2 SGTA STOML2 CNIH2 BCAR3 RBM14-RBM4 MORN2 MAZ DOHH SRSF7 YAP1 SMKR1 RPS8 METTL15 PDCD6 ANGPTL4 USP31 TRDMT1 SLC35C2 SNORD46 IGF2BP1 GLO1 YIPF3 NR1H3 AAR2 LRP6 SPG21 SSUH2 GSK3B LRRC49 EAPP HSDL1 SF3A1 NBR2 MANBAL METTL9 UBXN6 C12orf10 KCMF1 CCDC34 CASC2 SPEF2 SLMAP H6PD UBA52 RCOR1 BPHL BABAM1 MARK3 ZNF484 PABPC4 RPL38 JUND CHD4 LZTFL1 NCOA5 C1orf43 HSP90AB1 WDR62 CCDC13 SLC25A25 EFHC1 CCDC175 SIPA1L1 MNS1 SLC3A2 IFT122 LRGUK KLHL12 BTBD19 PPAN MN1 ERCC1 ZIM2 ARHGEF12 PREPL MZF1 DCAF6 PDE4A TSC1 RANBP2 ZNF497 REPS1 ZNF444 DPCD VRK3 RMND1 ARID1B CFL1P6 NSUN5 SNRPB2 PIN1 ZC3H3 MAP3K14 RUFY1 C8orf76 WDR70 MTHFR BLOC1S3 RPS7 CCDC57 PCM1 ITGB5 NDUFC1 GORAB CCDC30 NPHP1 SRFBP1 ZNF324 DICER1-AS1 UBC DYRK1A MMACHC RPL5 RPGRIP1L XYLB GEMIN6 MLEC CDIP1 CCNJL RPL27 KEAP1 EFCAB7 KBTBD2 CDK4 EIF2AK4 EPB41L4A-AS1 CDK17 DOCK1 ATP2B4 DMAP1 SLC1A5 ARFIP1 KDM5A STK11IP RNU6-1 DTWD1 DYNC2LI1 NEK4 TARS2 FAM120B FANK1 PHYHIPL RBM14 TINF2 EIF2D CHD9 NDUFS7 PIBF1 TOP3B PALM3 PEG3 up
## USF2_Q6 0.0011050 0.0051693 0.4729507 2.145309 0 242 MAEL UBR4 FGF6 NRIP3 NR0B2 OPRD1 ATAD3B TDRD1 UBE4B ATAD3A CNNM1 B3GALT6 COL2A1 FAF1 LHX9 SLC25A33 EPB41 MRTO4 ARHGAP12 SC5D RCOR2 ZMYND12 MICU1 USP2 LRP8 EMC1 RARG PTPRF BCL9L HPCA ADK UBXN10 MACROD1 UBIAD1 CGN RUSC1 AK2 NUDC RLF RGL1 B4GALT2 NET1 RAB3IL1 WEE1 RPL22 ACAP3 HOXC5 PLEKHA6 CELF1 ESRRA FEN1 CNST IPO13 WDR77 VWA2 POLR2L TRIM3 CTBP2 AMPD2 TFB2M SCYL1 PFKFB3 HOXC12 TXNDC12 TMEM258 EBNA1BP2 HPCAL4 TSSK3 ZBTB8OS ZNHIT6 FOXJ3 FOSL1 NAT10 ATXN7L2 PPRC1 ZBTB40 PITX3 TSKU RBBP4 MFSD5 RRP8 E2F8 HOXC11 DIP2B TGFB2 POGK PFDN2 PPCS RPUSD4 C2CD2L PLA2G4A RRP15 IL15RA PABPC4 CHD4 C1orf43 SERBP1 BATF2 up
## JDP2_TARGET_GENES 0.0009990 0.0051693 0.4312798 2.144156 0 1661 RERE TYW1 SSU72 SPEN KIAA0319L UBR4 SUN1 ISG15 HNF4A SLC9A1 PDP1 NUDCD3 MAPKBP1 UBE4B ATAD3A C16orf91 ZNF12 PEX10 KIAA0556 ACD MRPL20 ZDHHC4 DNAJA3 DIDO1 DDI2 RER1 TRNAU1AP AKR7A2 MFN2 PUSL1 TRAPPC3 TOLLIP-AS1 RFX2 PELI2 CDK11B EIF4G3 SNX18 PHF13 FAF1 CABIN1 TBL3 TTLL12 GTF3C1 NOB1 UBE2J2 MRGBP MGA PARD6A DHDDS GDF15 TELO2 YTHDF1 UXS1 FADD FZR1 LSG1 PPFIA1 NUMA1 KCTD13 PLCB3 NAPEPLD NCDN CLUH PRPF6 NFAT5 LRWD1 TAOK2 FBXO34 USP39 ADRM1 TMEM201 TMEM222 UCKL1 ZNF3 LIMA1 FAM86GP AKAP1 DDX19A RCC1 ICMT STX18 PPM1A EXOSC10 POLR3E CDK11A CC2D1B ZNF747 RAD50 ZNHIT2 CCNL2 LMBR1 C1orf122 GFER NUTF2 ADPRHL2 MLXIP TPRG1L ERI1 FLVCR1 STK40 IPO4 FBXL19 MAP3K9 PUS7 HOXB9 GID8 IFT140 AP2B1 C1orf159 ZBED4 CIB1 TRIT1 MEAF6 MEX3D ATP13A4 HES4 PPP1R35 SDHB EIF2AK1 CNNM4 INO80B WDR73 GNAS IDH3B SNHG3 REV1 MOK PPFIA3 AGR2 SPAG1 CENPT WIPI2 NARS2 CCDC87 CDC34 WDR60 ZDHHC7 CHERP MVD NOC4L CREBBP SNORA14B LINC00337 REXO1 ESYT2 SLX4 ZXDC BCL9L FGFBP3 MRPS6 FOXRED1 NAE1 PARD6B ATP6V0E2-AS1 IFT81 HAGH MORN1 MRPL55 LETM1 CRK AP3D1 TIMM44 HPS4 CHD2 ZMPSTE24 XPO5 UQCC1 RHOT2 MAPK8IP3 DCTPP1 MTG2 MRPL49 ENO1 LRTOMT MROH1 CASD1 SIGIRR CMTR1 LDLR MRPS15 BCL2L14 PSMD3 RBAK INTS4 PIAS4 MYO9A SKI FAM220A CAMK2D RAC1 PPP1R12C INPP5K PLEKHH3 RSBN1L REPIN1 ZHX3 POFUT2 WRNIP1 PARK7 PEX16 NUBPL PGAP2 DNAJC5 XPO6 TMED3 SNAPC5 ACOT8 TMEM219 USP10 MRPL14 ENTPD6 ERI2 ZNF536 SNRNP200 SPTAN1 DFFA PDIK1L RNF24 C12orf75 PPP6R1 CCAR2 SCAF4 LSM5 UBA1 PIGT UBE4A ABCF3 THOP1 NELFCD PTTG1IP MAST2 CHD8 CSNK1A1 VPS51 USP8 CCDC47 DDX51 BLZF1 RMDN3 PSMA3 MVB12A XXYLT1 ZYG11B SRSF1 LRRC14 CDAN1 UBN2 SMG5 SMAD5 SDHA CTBP1 ELL ANKRD11 WDR59 SPATS2L HDAC7 SPG7 WEE1 RPL10A NME7 SF1 ATP6V0E2 ACAP3 KXD1 WDTC1 SYNJ1 TUBG1 CACTIN C16orf72 DNTTIP1 ARID4B IMMT NAPB AAMP SLC22A18 PARP2 SBF1 AP4M1 MNT FNIP2 OSBP2 PLEKHG5 SLC9A3R1 NSFL1C NEIL2 CDPF1 CDCA4 FBXO31 CCPG1 HAUS5 FAU MAP2K7 SART1 MRPL17 PRPF39 ACTN4 STX12 DAGLB NIPA2 CBX8 MTHFD1L S100PBP TXNDC16 CNST KANSL3 TIMM9 BOP1 RPL18 BCL2L15 BAG5 LARP4B ZNHIT1 RETSAT GAK TTLL5 CBX6 GDPGP1 C19orf73 AKAP8 ANAPC2 STRIP1 CLPTM1L RBM47 TIGD2 HGS TPD52L2 MAPK6 RPL36 BCL6 TMX1 LRRC1 YRDC KIF3B KIAA0586 GNB2 STT3A RPS28 ZBTB21 RAB4A DNASE1 WDR18 PLOD3 RANBP1 ZSWIM3 PITPNA-AS1 RPL13A ARF1 ARPC1A FAM13A FAM193A PRCC NAMPT TMEM63B CCDC127 TFB2M RRP1 CPNE1 SNX12 POLRMT FAHD1 TSN YIPF2 DBP PRMT5 NOLC1 GATAD2A ILF3 GRHL1 CMIP PPP2R5B IRF2BPL NR1H2 ANKRD24 TRIM28 MED26 TIPARP MAGEF1 YKT6 AP1S1 SPAG9 NAT9 KHDRBS1 FANCA PAFAH1B1 RANGAP1 N4BP1 CUEDC1 RFXANK MKS1 BLOC1S4 RRP7A ARFGAP3 TRMT6 PDXP RNF126 MADCAM1 RHOT1 BSG RPL3 UBTF NOP56 ZDHHC3 NEAT1 ARMC6 PYCR1 RABIF CCDC114 RPA3 PELP1 AQR TMEM175 ALKBH4 SENP8 NR2C2AP MTHFSD TSSK3 HDGF CHMP4B TRMT44 RNF7 DDIT3 SNHG11 RPS6KA3 RAB11A ATP13A1 ENC1 DDX23 LYRM1 RN7SL525P C15orf65 CBX4 MYH9 PARN RNF19A NMT1 ZNRF2 FITM2 PGBD4 SRRM5 SPECC1L-ADORA2A B3GNTL1 PIGX RNF213 TXN2 SNX13 SIK3 TRIM11 LGALS3 U2AF2 ATXN1L KIF22 NUP98 NAT10 OGFOD3 KRT80 PCGF3 ATMIN RABL6 LRRC59 C4orf36 SLC38A9 ZBTB40 CHMP2B TMEM127 ZNF335 SNAPC2 RAPGEF3 FBXW8 MAPKAPK5 PRKAB1 C20orf27 POP7 HECTD4 DISP2 C1orf226 TRAPPC13 CANT1 DDB2 RAD23A RNASEH1 CDK12 RBM17 EHMT1 SRM GTF2H3 ERICH1 CIAO1 SEC23B RAB35 RPL9 EXOC8 DYNC1H1 MYPOP CMTR2 TOLLIP SPRTN SUGP2 DUSP10 AKAP13 ZNF106 RPS23 TRAP1 MIR191 PCNA LARP1B MYCN NUP50 AGO1 CCDC124 CBX1 RPS8 DNAJC9-AS1 METTL15 RAB3GAP2 ZNF784 MRPS33 PDCD6 BCKDHB CISD1 SLC35C2 SLC35B3 TOMM20 SNORD46 STOML1 SQLE SRRD EXOSC5 NOL10 SNORA37 SLC35F5 RPS29 MRPL24 RCE1 SDR39U1 ZWINT TSEN2 ZNF684 ZFAND2B DNAJB2 MAGOH PTPN23 GPCPD1 RN7SL832P JMJD4 XRCC1 VPS4B ARHGEF18 GBA NUP214 SH3GL1 SIRT6 ARMC7 HK2 PITRM1 DYNLL2 ALYREF PPA1 XPOT DRAP1 PTOV1 DDA1 NAA25 SURF4 METTL9 TDRD7 PITPNB PDAP1 LARP1 MLF2 STIM2 ARL16 E2F1 LIPE MAP2K3 TPR GATC GGPS1 H6PD UBA52 DPP9 DCUN1D3 NAF1 NWD1 FAM151B RNF170 SSNA1 WDR89 RPL38 TOM1 JUND USP21 ELMOD3 RPL4 PRKAR2B RALGDS MED9 NCOA5 RPL37A ZNF547 HSP90AB1 DMTF1 GINS2 SEC16A EFHC1 RECQL5 ABHD5 SIPA1L1 PCDH9 DNMBP SLC3A2 SAFB2 MCM3 MGMT ATP2A2 HMG20A CCS CHCHD4 ZNF865 CNOT4 MIS18A HMGB3P22 UBTD1 UBE2V2 ERCC1 PIP5K1B ACAD9 TERF2IP EEF1D ALKBH5 MMS19 HAX1 NUP153 WDR20 STXBP1 TK2 AK7 RPP38 TRMT2A TRIM35 ZNF79 ZNF460 ZFPL1 COX8A RMND1 IST1 HOMEZ ZNF217 P4HB MRPL12 UBAC1 C12orf65 GCDH AP4E1 TMEM50A ZC3H3 STK38 TMEM116 BICD2 RPS3A UTP6 CHMP5 INTS7 DTD1 RPS6KB2 PAK1IP1 BRF2 DCAKD ARGLU1 IFT172 STYX MCM8 BRWD3 SYS1 up
## AEBP2_TARGET_GENES 0.0010020 0.0051693 0.4360418 2.142998 0 1030 PDXDC1 KIAA0319L KIF16B SHROOM3 INPP5B NPHP4 ZNF12 GSPT1 DNAJA3 CYB5B TRAF7 PGP GIPC1 SCUBE2 TRNAU1AP EIF3B AMBRA1 KIF1B MTOR ZNF629 RPPH1 TULP3 SLC7A6 PRR15 LSG1 HOXB6 MEGF11 PRKCE SPRED2 NCDN CDCA7L IDH3A CLRN3 RBCK1 CDON LIMA1 TMEM53 FDFT1 TPBG ANXA4 PHF14 ARID4A LMBR1 HDAC1 DGAT2 ERI3 ANKRD13A EPS8 KPNA6 LRRC41 NIPAL3 MEAF6 GMDS STAP2 NR6A1 VPS41 ACP6 RHCE AVL9 TARDBP CHEK2 MGRN1 LINC00461 GGCT PCAT7 STPG1 STK35 PPFIA3 OXR1 FAM120AOS UQCRC2 SRC ZDHHC7 MVD NOP2 TRIP10 EVI5L FRMD5 PLS1 LSR ZDHHC5 NFATC2IP TBC1D10B RPLP0 ABCB9 FAM227A PPP2R5A ADAMTSL5 GPRC5A TMEM62 TIMM44 KRT8 GPBP1L1 EFNA1 NUBP2 DPH2 CASC4 TRAFD1 ARID1A OGDH ZNF273 SNX1 IQCD RRBP1 PRMT1 PDXDC2P MRPL48 BNIP1 PARK7 AKIRIN1 KLHL20 SNX8 ACOT8 TMEM219 SRI MED19 ERI2 MVP FBRS AGFG2 UBA1 CDK16 NGDN DDOST IL23A ZMYND8 MTMR12 NRSN2 RMDN3 DNMT1 PSMA3 TM9SF4 RPLP1 DHX38 CBY1 TJP3 COPS7B SRSF1 DOK4 AKAP8L TMEM161A PIK3R3 ZNF823 PHRF1 OSBP ALKBH7 ANKRD11 RNF181 SPG7 TOM1L2 MADD RPL22 SCAF1 ZNF473 OTUB2 PRR14 NOL6 ALDH4A1 AAMP RBM15 PARP2 AP4M1 MNT BRAT1 HOXC6 PLEKHG5 TOX4 RPL18A IFIT3 CEP250 ZNF774 PICK1 ZKSCAN5 GPATCH2 ZC2HC1C CEP164 RPL18 MSH3 PPM1L IPO13 TMX2 AP5Z1 RMI2 TTLL5 WHAMM NDUFB2 SREK1 RBM47 HGS KDM4A XRCC3 GPR160 DHCR24 BCL6 RPS12 PER2 GNB2 STT3A ABHD2 ZSWIM3 FAM13A STARD3NL RPRD1B RMND5B AKAP9 SEMA4B C17orf75 KATNB1 ZNF219 ATG9A IBTK MAEA GNG12-AS1 C4orf47 GATAD2A ILF3 DAP3 DDX49 TMEM38A RMND5A FAM110A RUVBL1 SEMA3C SHARPIN MPND DROSHA LRRC61 SPATA17 DCAF15 SLC35E2B PRELID2 UQCR10 LRPPRC SCAI RAB11B RPS14 PAXIP1-AS2 MEPCE DNM2 PDXP TPCN1 VPS37C DDR1 PTRH1 MAGI3 DGCR8 GRIPAP1 ZSCAN20 POLG SLC16A5 UTP18 DCTN4 DPF2 RFX1 AQR TRMT44 RHOBTB3 COQ7 RAB11A LYRM1 C15orf65 C9orf16 GALK2 BCL2L1 CDIPT CA11 NMT1 SRRM5 ZNF689 LINC00649 SHC1 NPDC1 ASH1L PAN2 MAP3K13 AATF YY1AP1 GPR108 FAM219B NFE2L1 SERINC5 TSTD1 PUS1 PPP1R13L DUT RGMB FKBP9 TIMM8B NRL ZNF354B FUS RBBP5 TRIM33 HHAT ACTR3C FIS1 PRKDC CADPS2 TRAPPC13 SQSTM1 MRPS11 HMGCS1 MALSU1 MFSD6 SUMF2 MORN2 CSNK2A1 POLR1B ZFAND6 KHSRP OS9 DOHH ZNF106 ZFYVE21 ZSWIM4 ANKHD1-EIF4EBP3 MYO9B ANKHD1 CCDC124 TMEM260 UIMC1 CAMTA1 FAM161A NCOA2 TUBB4B HAUS8 LINC00881 RAB28 SSBP1 SART3 EXOC4 ABCA7 SLBP ZWINT TCP11L2 LSM4 DIAPH1 VDAC1 GSK3B ISL2 HNRNPUL1 UQCRH CDC42EP4 TTC7A ASNS ANKRA2 GBA CCDC61 TBC1D22A ZNF785 ECE1 PTOV1 DDA1 SAP30L RIC8A PTCD3 RAB2B ARL16 RALY LIPE FAM126A STX10 FLCN UBA52 C21orf58 PBX1 SIGMAR1 DPP9 DCUN1D3 CEACAM1 MOCS3 CHD6 PURA BABAM1 USP3 ANKZF1 RPS27 BET1L HSP90AB1 SARS2 WDR62 SLC25A25 DNMBP MCM3 RPL19 AP1G1 HMG20A PYGB BATF2 PSMC3IP BZW2 RAB11B-AS1 EEF1D DCAF6 FHIT TMCO1 TTBK2 RBM22 IFT52 PCNT VRK3 HOMEZ FDPS MPZL1 P4HB DCAF11 MPV17L2 DPM1 CYTH2 RUFY1 RGMB-AS1 RCCD1 ZNF687 IFIH1 MSANTD4 YIF1A CSPP1 DCAKD SUCO SYS1 JUP CKAP5 TYMS RHBDD3 ZNF576 NEDD4L DYRK1A CCT5 CCT7 IGF2BP3 ZNF414 STRIP2 TMEM60 MLEC ZNF574 KBTBD2 RBBP6 EPB41L4A-AS1 MRPS27 LRRC31 ZCCHC10 RPL23A METTL17 ZNF77 TIGD5 TRIM68 AP3M2 DOLPP1 HSCB OXA1L STK11IP KDM4B KDM3A AFF1 CMC2 TTC13 POLR1D ACYP2 RPL30 TARS2 CHCHD6 WDR5B UBE2S CIC GTF3C5 HYKK KCTD9 TXNIP MOSPD3 ANP32A FOXP1 FIZ1 RIOK2 ANAPC13 NAB1 PWWP2A C6orf62 SLC26A2 SYS1-DBNDD2 RAD51B FLAD1 PYGO2 DUS4L GLRX5 PPIA CD164 FAM174B ARG2 STXBP5-AS1 PAFAH1B3 up
## HOXC6_TARGET_GENES 0.0010030 0.0051693 0.4359883 2.142429 0 1001 RERE UBR4 CDK13 SERPINB5 THRAP3 TMEM248 TBX6 NUDCD3 ATAD3A HMOX2 AAGAB TRNAU1AP TRAPPC3 PAQR4 C2CD3 NOB1 C1orf198 ZNF398 ARHGAP32 F2RL1 GSS KCTD13 KIAA0895 POLR1C LRWD1 RSF1 PEF1 SMARCA4 CDON CES2 LIMA1 SNHG12 SH3TC2 SPATA2 STX18 ANXA4 PMS2 ARID4A RAD50 ZNHIT2 CTH GFER EEF2K USP54 RNU4-1 TRIM7 NMRAL1 UBE2I FAR2 CYP51A1 IPO4 CYSTM1 DDRGK1 GID8 PKP4 CWC25 ETFA TRIT1 ZNF598 FAM214A PPME1 SF3B3 COG4 CAPN2 TMEM184A INO80B ANKRD54 ZNFX1 YDJC AGR2 USP42 WDR60 FASTK NOP2 ALG8 SKIDA1 LSR SUPT3H SLC35D3 PKM UBE3A SETD1A CUX1 LETM1 GPRC5A AIMP2 SCAMP2 NOL9 PSMG3 LAD1 GTPBP2 LRTOMT HMGXB4 CASD1 ELOVL1 APRT TMEM259 SLC27A5 ARFIP2 VILL CMTR1 TTPAL PIAS4 RNF216P1 MYO9A RNF216 ADAT1 MYCBPAP PRSS3 RMRP IQCH RPL24 ALG1 NUBPL POLR3B BBS9 CLNS1A MCCC1 SNRNP200 SPTAN1 GDAP1 PPP6R1 ZNF646 TIPIN AUP1 WDR55 UBE4A MAD2L1BP IL23A ZMYND8 PPP6R2 DHPS CLDN12 MVB12A RPLP1 GANC KDM1A ZNF212 UBN2 SPINT1 RRP9 FAM160A2 ZNF839 SPATS2L RNF181 KIF3A TMEM177 ZNF473 EIF3L SYNJ1 CACTIN PTRHD1 IMMT PCF11 ALDH4A1 TRIM56 PPP1R14B AP4M1 TMEM87A SNHG9 BRSK2 ATXN2 TNPO2 PARP3 ANKS1A HAUS5 CCDC137 GATM VPS39 RPS2 NFYC LACTB2 COMMD4 IFRD1 MUS81 FDXR MIR320A GDPGP1 DDX55 ZNF692 MAPK6 COX19 LRRC1 ABCB8 GGA3 STAG3L5P-PVRIG2P-PILRB ATG16L1 TRIM41 WDR18 ENAH AMPD2 ARF1 STARD3NL NAMPT MTR MT1E LRP10 CPNE1 PMS2P3 NBPF1 MAEA NOLC1 BDH1 DDX49 CERS6 ZNF74 SHARPIN NDUFS3 CEP70 RAD52 TMEM170A KHDRBS1 LZTR1 LRRC61 CBFB UQCR10 CD320 ALDH7A1 TOMM22 BLOC1S4 IWS1 NIPA1 PEX1 XKR9 RELL2 RPS11 NR2C1 ERC1 RN7SL2 IMP3 RBM33 USP35 RNF111 FANCC AGPAT5 ARHGEF26-AS1 POLG UTP18 TMEM243 DPF2 ALKBH4 SENP8 PSMB10 NEK8 SMG7 MYH9 ETF1 CA11 AJUBA ZBTB8OS PNKP LINC00649 HNRNPAB PAN2 TLCD1 SNX13 SERGEF CSNK1G1 SERINC5 LMO7 PPM1H PPP1R13L DUT FNIP1 ARMC10 CXXC1 RABL6 SLC25A39 MKLN1 DUSP28 PIWIL4 ZFAS1 TP53I13 SBF2-AS1 ACTR3C PTPN13 RPL34 SOCS7 RBBP4 EIF3G UBAP2L RPS15A HECTD4 C1QL4 MAP3K5 TRAPPC13 DDB2 POLR2E MAP3K11 CTDSPL2 HMGCS1 ABCB10 RNF187 EXOC8 LINC00471 MAZ FAM222B ZDHHC12 NDUFC2 COG2 CCDC107 SPRTN CIB2 TXNDC11 AAMDC KHSRP ZNF668 OS9 POLR3D ANKHD1-EIF4EBP3 ZNRF2P1 PPP2R5E RNU4-2 SMKR1 TOMM40 UVSSA NUP50 ANKHD1 DNAJC9-AS1 METTL1 RABGEF1 GGA1 ANGPTL4 SNORA84 SLC35C2 ATP8B1 TMEM106B TRIM25 KCTD21 ZNF280D FEM1B SSBP1 YIPF3 PFDN2 NR1H3 SCP2 C3orf52 TOMM7 ZWINT TSEN2 PAWR ZFAND2B PTPN23 RCOR3 CCT6B HDLBP HINT1 DDX54 XPOT SAP30L BMPR1A PDAP1 LARP1 ATAD2 RPL31 CSAD TMEM106C RABGAP1L CSNK1D ARV1 IL5 RPS27A GGPS1 NDUFA13 MRPL51 SLC12A9 SLC39A9 TSPAN12 MARK3 USP3 ZMAT5 NDUFAF4P1 BBS4 TPST1 TMEM39B UBE2L3 HTT MSRB2 PKMYT1 TUG1 C1orf43 EFHC1 RPS9 SNRPD2 FZD1 TAS1R1 CRAT TMEM9B PPAN SNHG17 BZW2 CXCL3 NTMT1 MRPS7 LIG1 MRPL4 UBR5 TSSK6 CPSF4 LRRC46 ZNF79 ZFPL1 FIGNL1 VRK3 IVD MYO19 OSBPL10 SNRPB2 NDC1 TCF12 MPV17L2 RAB6A TYMP ICK GTF3C2 IFT172 WDR27 SIDT1 TAF1B SETD5 ZNF131 CA5BP1 SRP54 SCARB2 DYRK1A MMACHC PLEKHH1 ATRN TFCP2 THAP5 ZNF860 AKT2 HRK FRMD3 CDK4 GORASP2 SNHG16 YARS2 EPB41L5 MRPS27 RPL23A ENSA CDH24 WDYHV1 TAF6L SERP1 BUD31 KDM3A TTC13 ARHGEF26 POLR1D BRAP CD44 SNRPA SERAC1 IGSF8 RBM12 BRIX1 ALKBH2 GTF3C5 FAM83E NUP188 TMEM143 PIBF1 MOSPD3 ATP6V1D ANP32A KCTD21-AS1 BIRC6 FIZ1 SRP14 B9D2 UPP1 FOXM1 NIT1 AEN CETN3 C6orf62 GART TMEM128 GTF2IRD1P1 FLAD1 DDIT4 TMEM232 PACRG GTF2H5 KIFC2 RPF2 up
## KLF17_TARGET_GENES 0.0009990 0.0051693 0.4296878 2.136410 0 1681 NTSR1 UBR4 ISG15 ANKRD13C DNAJC16 SLC52A3 SLC9A1 ARHGEF16 PCDH8 MAPKBP1 PHACTR4 MAGI2 THSD4 JMJD8 AURKAIP1 RER1 CASZ1 TRAF7 GIPC1 TRNAU1AP SOX8 SRRM1 RAB11FIP3 SLC4A2 PUSL1 SLC35A3 MNAT1 EPS8L1 FAF1 TAF4 CABIN1 KAZN TBL3 ZNF609 ZNF629 FAAH TTLL4 DHDDS ARHGAP32 TRIP4 FZR1 LSG1 INO80 HOXB6 OSBPL2 CABLES2 VSTM2L PRKCE SPRED2 CDCA7L CLUH MLST8 CCDC86 MRTO4 PEF1 SMARCA4 CDON UCKL1 HOXB3 ZNF3 RASA4CP WDR90 AKAP1 STX18 RCC2 CCT6P3 MAD1L1 SIM2 POLR3E CDK11A TCFL5 BMS1 ADPRHL2 HOXB-AS3 PTPN12 USP54 ZKSCAN2 INTS5 BDKRB2 RPUSD1 ERI1 CCSER1 SDF4 UBE2I DGAT2 STK40 CXorf56 HOXB9 CLUAP1 CHGB PPP1R37 RNF32 MAP7D1 FBXO22 SBK1 TRIB3 FAM160A1 HES4 PDCL3P6 THAP4 MORC2 PPP1R35 PIEZO1 NR2F6 FAM160B2 GNE RHCE INO80B CT62 AVL9 GNAS MGRN1 FASTKD5 CAPN1 EMC1 FAM66B STUB1 PPFIA3 CCNK GUSB HHLA3 TUFM NEO1 PHLDB3 NCAPH2 NOC4L EVI5L REXO1 PLS1 SERTAD4 ALG10B PKM SSTR5 ANKRD13B EFCAB14 NAA60 PLEKHA5 LINC00511 SETD1A SYCE3 KPTN FRMD4B MIB2 GTPBP3 EPHA2 AGL ZC3H18 CDR2 SRCAP ABCB9 ACADSB ZNF384 LMF2 LUC7L HAGH ZMYND19 LRRC57 LINC00115 CRK EPB41L1 TPRXL KRT8 GPBP1L1 TLE3 EFNA1 CHD2 NUBP2 HUS1 CLPB PANK2 ARID1A OGDH LMF1 CHKB FAM122C MTUS1 KCTD5 C8orf58 TTC26 MTG2 IL11 STX3 ADNP2 VPS37B ELOVL1 AHCYL1 AIFM1 C1orf21 UBIAD1 FGF12 VILL TFDP1 PIGU WIZ CDC42EP1 PIAS4 ABR ANXA11 RAC1 CHTF18 PPP1R12C MRPL48 BNIP1 DOK7 DHCR7 BPNT1 HOOK1 ARFGEF2 SREBF2 CHCHD3 TUBB2A NEIL1 AKIRIN1 AP1G2 ZNF827 ALG1 POLR3B C15orf61 SGSM1 EFNA3 UBOX5 SNAPC5 AGAP3 ENTPD6 EEF1A2 HSD11B2 HOMER2 AGFG2 RNF24 RTEL1 GDAP1 C12orf75 B4GALT6 PPP6R1 EIF2B3 CLDN6 RBPMS TIPIN LSM5 GUCD1 CDK16 B4GALT5 RPTOR RSPH3 FARP2 CHD8 KLK10 ASPHD2 VPS51 NRSN2 TIMM22 DDX51 RMDN3 CD55 ZNF205 TRMT1 RND2 TM9SF4 PAK1 TEF KRBA1 GANC TJP3 COPS7B B4GALT2 SNRPD3 LINC00957 ANKLE2 CDC42BPA PSD3 RPS6KA4 DOK4 KDM1A WFS1 DUS1L NELFA PHRF1 HOOK2 GIT1 ZNF839 ELL VEZT SPATS2L AGAP2-AS1 EPN2 TOM1L2 CAST ACAP3 UBE2H WDTC1 PDF PTN OTUB2 MRPL28 CACTIN DMTN SLC35B2 HOXC5 GGT1 PPP1R14B PCSK4 PARP2 RPL29 PLEKHG5 TMEM87A NSFL1C TRABD ATXN2 TNPO2 ATXN10 FBXO31 ANKS1A HAUS5 ZC3H12A SP6 MAP2K1 STX12 DAGLB NIPA2 SNORD60 PPIL6 MOV10 SF3A3 FAM122B KANSL3 GDI1 DNAH2 SETD3 SBNO2 LETM2 RNF215 DDX55 RUVBL2 KDM4A SH2B1 KDM5B TFIP11 PER2 MACF1 GNB2 ZBTB21 SLC29A4 FGD6 KIF1A RANBP1 MLX ENAH CLCN7 AKAP9 C17orf75 PEX13 KATNB1 SNX12 BRPF1 XRRA1 BCORL1 C12orf49 GNG12-AS1 PRMT5 NOLC1 MAN2C1 SPIRE2 TSC22D4 GATAD2A LINC00303 ILF3 PFKFB3 BDH1 SYDE2 HIVEP3 LINC01006 CMIP CITED1 CTSH COPB1 CERS4 IRF2BPL NR1H2 PSMD12 ANKRD24 HSPBP1 MED26 NDUFS3 THUMPD1 BHLHE40 SNHG7 YKT6 IQCH-AS1 RAD52 SPAG9 AGO3 FANCA NMNAT1 LMNA HDAC4 DZIP1L SLC35E2B PRELID2 HSD3B7 CAMK2N1 TOMM22 RFXANK RPS14 MPLKIP GRIN3B TJP1 NR2C1 ERC1 STIP1 LRRFIP2 VAMP3 EXO5 FANCC MAN1C1 SAMD11 C11orf49 DGCR8 MTHFS PCED1A REEP6 TMEM30A AARS2 WNT10B EIF1AD KCP ELAVL1 ZNF608 POLR2C POLR2J CSNK1E DLG4 PTK7 SIK2 COQ7 RAB11A BPTF RPL11 ACHE CAPN8 RHOC GOLGA3 GALK2 SMG7 MYH9 C12orf76 DHX33 ARHGAP10 PNKP SCAND1 NDUFB7 TSHZ2 ARHGEF2 PATZ1 PITPNM2 FOXJ3 SLC35F3 SIK3 USP48 NFE2L1 FAM20B CIZ1 RNF217 DNAJC6 MRPL11 PPM1H ILVBL ANKDD1B DLX3 AGPAT2 AFF4 PCGF3 FANK1-AS1 POLE4 SAR1B LRRC42 RTEL1-TNFRSF6B CORO2A RAD51D PI4KA CACNB4 VPS16 ERBB3 TMEM127 ZNF335 SNAPC2 GALNT12 RRP1B RBBP5 FBXW8 NFIA MAPKAPK5 TTC34 PCIF1 ZNF394 SLC25A21 RPS15A HECTD4 STX4 KIAA0513 SMARCD2 RAD23A PDLIM2 UGT8 SQSTM1 NABP2 KCNC3 BTBD6 VPS25 PCOLCE-AS1 ABCB10 TBKBP1 EPHA10 IQUB FAM222B C4orf48 MAFF IDUA SOX13 NDUFC2 CCDC107 NTF3 ZNF668 MPDU1 YAP1 DTNBP1 UVSSA PLK3 MYO9B MSL1 LZIC LTBP3 TRIM52 SORT1 METTL15 PDE8A ACSF3 ATL2 PPP6R3 REEP1 TUBB4B USP31 LRRC37B TRDMT1 ZNF48 HAUS8 LRRC37A3 ANO8 PHF21B NRXN2 PKDCC WDR83 RPS29 NR1H3 ABCA7 AAR2 DGUOK LRP6 TCP11L2 DPM3 PAWR DIAPH1 VDAC1 ZNF467 AP5S1 SRPK2 SMPD2 URB2 JMJD4 EIF4G1 CGNL1 FAM86B1 CCT6B SH3GL1 CAMK2B FAM89A RARA MAN2A2 PSMF1 TBC1D22A SSBP3 ALYREF SMAD7 PPP2CB RRP15 PTCH1 METTL9 ZCCHC2 UBXN6 PDAP1 ATAD2 SNX7 NOSIP RABGAP1L COA1 CSNK1D HARS2 GATC PCDH1 ABCC3 GNGT1 RILP RCOR1 DPP9 C15orf62 PTK6 RPS20 PGBD5 TOM1 NDUFAF4P1 ART5 CDK5RAP1 RALGDS EBAG9 MED9 HERC5 STARD3 SFPQ SPIRE1 DMTF1 EFHC1 SLC3A2 SAFB2 COG1 FZD1 MGMT SCYL3 AP1G1 KRT18 ATXN7L1 HMG20A SLC39A3 FOXP4 PRRG2 KLF13 WDR26 PDS5A KCNK1 CRAT RTBDN ZNF341 PPAN CAMKK1 UQCC2 C2CD5 NTMT1 ALKBH5 RPS26 PDE4A TTC19 NOXA1 STXBP1 MATN1 TSPAN9 MRPL4 TRMT2A TRIM35 REPS1 BCL7C TFAP4 RMND1 PRKCSH ARMC4 ZNF217 GCNT2 ARID1B OSBPL10 PUS10 WDR34 PHB C12orf65 DGKQ WAC-AS1 CNIH3 ZC3H3 RBM28 DLX6 RPS3A DTD1 RPS7 SAMD4B YWHAE TST PAK1IP1 ITGB5 BRF2 ANKRD36 DMC1 SHISA7 NDUFC1 CYP46A1 SRFBP1 GON4L C14orf93 DNAJC2 ETV4 JPX PMPCB TMEM87B MRPS23 FBXO38 ZSWIM8 TNS1 DYRK1A SP8 IGF2BP3 XYLB MPST C11orf74 ALKBH3 ZNF860 PRRX2 ANKRD40 LBX1-AS1 RBFOX2 PARVA SSBP2 UFC1 EFCAB7 NDUFA2 WSB1 RBBP6 BIN1 DDX11L10 ZNF268 CASC9 EPB41L4A-AS1 ADSL ZNF544 PFKP PTDSS2 SLC1A5 MAFK PPIH AP3M2 TRIM47 BUD31 KDM5A WDR4 SULT2B1 AC007389.1 MAML3 DTWD1 GFM2 ZFP1 ATP8B3 EEFSEC ZSWIM7 COQ10A FANK1 ZNF337 ELAVL2 RAP1GAP ZNF628 EIF2D ERLIN2 STMN3 KCTD9 C2CD4C TPM3 TOP3B KLRG2 TSPAN10 PEX3 PHF20 MIF4GD SIL1 SNAP47 ARHGEF25 CETN3 NUP85 SDE2 APTX TECPR2 MAPKAPK3 TCTE3 GLRX5 PSMC2 RPL41 GBX1 SPRYD4 METTL2B FAM174B RFC1 RAB24 ASCC1 TMBIM1 HNRNPF ITSN1 SPTLC1 PSMD1 SCAP PDZD8 TTC5 ZNF714 PLEKHM1 CLDN7 LMX1B PRDM15 NDUFA4L2 GEMIN5 SCARNA13 SLC39A13 STX16 ZNF837 RNASEH2C ADCK2 CASP9 GMNN TRAPPC9 LFNG ALG10 TUT1 NPLOC4 RUNX1 PAQR8 DENND4B LINC00475 MRPL45P2 NBL1 EFTUD2 RBBP7 IRF9 MATN1-AS1 YTHDC2 FBXO36 HOTAIRM1 BANF1 PDXK ATG4B up
## CREB3L4_TARGET_GENES 0.0010000 0.0051693 0.4326200 2.134880 0 1195 EPS8L3 MYBPC1 PDXDC1 SSU72 RNF207 ISG15 DNAJC16 SLC52A3 ACTR3B ATAD3B THRAP3 TBX6 ATAD3A FAM118B TP53BP1 PGP ZNF282 EIF3B SLC35A3 C2CD3 LMTK2 FERMT1 CYP2J2 GCNT3 RPPH1 DHDDS ARHGAP32 LSG1 INO80 FLYWCH2 WWP2 KIAA0895 SPRED2 NIPAL1 TXLNA CLTB CDCA7L CNGA1 CCDC86 PEF1 ZC3H7A CHMP1A SMARCA4 TMEM222 EDC3 HOXB3 CYB5A POLD2 THBS4 NUTF2 HOXB-AS3 USP54 TUBGCP5 UBE2I DGAT2 ERV3-1 PKP4 PPP1R37 MAP3K6 AP2B1 GUK1 CIB1 HMGXB3 RNF32 PPME1 SF3B3 CCDC130 COG4 METTL3 CREBZF PUM1 EIF6 WDR73 TNRC18 LRRC45 TNRC6A LGR4 FAM120AOS GUSB MVD CFDP1 SLC7A6OS EVI5L ST7 VSIG10 ALG8 TSEN54 PKM PAFAH2 EFCAB14 HOXC-AS2 ZNF117 L2HGDH TM7SF3 ZDHHC5 ZFP64 SMG1 ZC3H18 METTL16 CLIP1 PTBP1 PAXIP1 RPS21 DIS3L2 ZNF384 GRHL3 GPRC5A GAS5 LRRC57 ATXN2L SAV1 TIMM44 KRT8 ANKRD18A GPBP1L1 ADK CHD2 DPH2 TICAM1 XPO5 SZRD1 ARID1A SF3A2 FAM201A RRBP1 PSMG4 PSMA5 PTPRK ENO1 NOP14 TMEM259 UBIAD1 NDUFS4 MYO1D MRPS15 BCL2L14 CA13 ST7-AS1 PSMD3 SRRT PRMT7 RSBN1L REPIN1 PCGF1 RPL24 PEX16 PRLR SNX8 FTO CISD3 ERI2 CLNS1A ZBTB45 GDAP1 PPP6R1 ZNF646 TIPIN NUDC WDR55 DDX41 NGDN TNPO3 SCAPER NAALADL2 PHKB MTMR12 DHPS TIMM22 NXT1 BLZF1 CD55 DNMT1 TM9SF4 XXYLT1 SGSM2 RGL1 ESRP2 PSD3 PTGES2 LRRC14 FAM135A NELFA AKAP8L UBN2 SH3YL1 NCEH1 PINX1 OSBP NET1 GEMIN8 TM9SF1 TOM1L2 RPL10A PRPF8 PRR7 KLHDC2 NME7 KIF3A STRN3 DNTTIP1 PTRHD1 TCERG1 EPCAM PCF11 RPS3 PARP2 CDCA7 SNHG9 PICK1 HADH CCPG1 PIGO SLC35B1 RPS2 GPATCH2 CEP164 STX12 COMMD4 CPT2 MSH3 BCL2L15 SETD1B PDSS2 ZKSCAN1 WDR77 CLPTM1L SREK1 RBM47 KDM4A COX19 DDX58 ATG16L1 FGD6 DBNL NUP93 PRCC TSPAN1 ULBP3 ODF3B PAK6 SNX12 RC3H1 CLCN6 SFI1 TMEM65 TSN IBTK C12orf49 MAN2C1 C1orf109 LINC01006 CTSH NSUN3 TRAF4 MED26 NDUFS3 PRR15L ST7-OT4 KLC2 MAL2 MAGEF1 MAP4K3 RAD52 PAFAH1B1 CBFB SPATA17 FBXO28 PRELID2 LRPPRC CHAC1 TSR1 NIPA1 KITLG PDXP ERC1 STX19 ZNF276 LAS1L USP35 RPL3 FANCC PIGG DGCR8 NEAT1 HSD17B12 AARS2 MRFAP1 PLEKHJ1 GTF2F1 PELP1 MSI2 COX14 PSMB10 RABGAP1 COQ7 MVK BPTF TRIO DDX23 CAPN8 LYRM1 RHOC ZNF317 C15orf65 GOLGA3 ISOC1 PARN CA11 SRRM5 LCA5 HOMER1 ZNF689 ZNHIT6 ZNF688 AATF ARHGEF2 ASRGL1 SNX13 PSPH ZNF343 FOSL1 LMO7 NCL PUS1 PRPF19 SAR1B SCARNA17 MAN1B1 SLC38A9 ZDHHC8P1 PIWIL4 GLG1 USE1 ZNF394 SH3D19 HECTD4 ECSIT MFSD5 ECE2 RNASEH1 SQSTM1 RNY4 KIAA1217 WNK1 STOML2 CDK12 DIP2B BCAR3 ACER2 ZC3H4 CSNK2A1 MAZ ESRP1 AHCTF1 NDUFC2 ZNF668 ACKR2 DUSP10 DOHH COMMD1 ZSWIM4 RPS23 SNHG8 PCNA PLK3 MUC13 MET LTBP3 VPS18 TRIM52 VPS9D1 GDF9 POT1 RABGEF1 ATL2 BTBD10 KIF27 EXOSC5 KCTD21 FEM1B KCTD7 NASP GLO1 SCP2 C3orf52 PPIL2 ZWINT DIAPH1 GSK3B RPUSD4 EAPP ROCK2 GTF3C4 MBTPS1 EMC10 SLC39A8 GOT2 PSMF1 TBC1D22A ZNF785 DDX54 ECE1 PPA1 XPOT PTOV1 OSBPL3 SAP30L RIC8A PITPNB BMPR1A C12orf10 CSAD TMEM106C LIPE RABGAP1L TIGD6 GALNT10 TPGS1 MRPL52 GOLGA5 COX7A2L MRPL51 DCUN1D3 SLC12A9 GLCE TSPAN12 ZBTB43 RPS20 NDUFAF4P1 USP21 ELMOD3 EBAG9 CCDC7 SFPQ BET1L WDR62 SIPA1L1 MNS1 COL1A1 MAP4K2 AASDH FOXP4 RNVU1-6 STK3 PPAN NFKBIZ LINC01003 RBM22 PBLD HAX1 RANBP2 PSMC4 GALNT7 UBR5 RPP38 CPSF4 REPS1 ZNF79 TIMM10 SLC50A1 SLC25A36 FDPS PNPLA8 LRRC28 MRPS30 P4HB OSBPL10 C12orf65 GCDH PMVK UBE3D RUFY1 RCCD1 MTHFR MSANTD4 TMEM209 UQCRQ EIF4EBP1 RPL36AL KAT5 ARGLU1 MUC1 TYMS DICER1-AS1 TTC23 DNAJC2 HIRA ZNF131 SRP54 FKBP2 ZNF576 TMEM87B MRPS23 FBXO38 FOXA2 CD24 RPGRIP1L CCT7 MLEC SP1 ZNF860 PSME3 CCNJL USP37 SSBP2 SAE1 RPL27 THRB-AS1 CDK4 LRRC66 DYNLT1 ASPH SRSF11 ZNF77 DMAP1 MBD1 OXA1L FAM71E1 KDM4B AFF1 CEP350 CMC2 CHEK1 MATR3 GGA2 BRIX1 ZNF628 LINC00910 KCTD9 SNRNP70 ZFP36L1 ATP6V1D PAXBP1 DPM2 NAB1 MIF4GD HDDC3 MMAB POLH PWWP2A CETN3 FPGT NUP85 SDE2 MED15 WDR35 ITPKA FLAD1 TMEM232 PPIA RHOF PSMC2 ZNF425 EXOC5 LLGL2 CSTF1 CD164 COX7C CRKL STXBP5-AS1 CASKIN2 OSER1 COL17A1 ARPC4-TTLL3 ITSN1 TTC5 DET1 CLDN7 KAZALD1 PHF7 SRD5A3-AS1 up
## HOXA1_TARGET_GENES 0.0010020 0.0051693 0.4342534 2.133911 0 1005 PDXDC1 KIAA0319L CDK13 DNAJC16 SLC52A3 ADAP1 THRAP3 NOP9 DMRT2 AP001372.2 ATAD3A C16orf91 RALGAPA2 TP53BP1 RAB11FIP3 MFN2 EIF3B RFX2 CDK11B FAF1 TBL3 MYO10 NOB1 RNPS1 NBPF3 RPPH1 DHDDS STARD10 TRIP4 FADD TBRG4 F2RL1 POLD3 KIAA0895 GPN2 NCDN TXLNA PRPF6 MRPS34 CCDC86 CLRN3 ADRM1 SMARCA4 CDON TMEM222 ZNF3 SPATA2 PPM1A ZNF830 CDK11A PMS2 ZNHIT2 CTTN ZNF174 UBE2I STK40 CXorf56 EPS8 CWC25 FBXL18 NPRL3 CCDC130 ATP13A4 THAP4 GLOD4 CYP4F12 METTL3 ACP6 IDH3B MOK CENPT UQCRC2 NUDT22 WDR60 CFDP1 TMUB1 TRPT1 SUPT3H ALG10B KPTN RPL13 PHF12 NSUN4 NAE1 DHX29 LRRC57 AIMP2 AP3D1 TIMM44 EFNA1 NUBP2 ZMPSTE24 PANK2 SF3A2 ISG20L2 SNX1 XPNPEP3 FAM122C IQCD DCTPP1 MTG2 MRPL49 ENO1 ABCF2 SLC27A5 C1orf21 ARFIP2 CMTR1 FAM220A RNF216 STYK1 ADAT1 STEAP2-AS1 RPS6KA1 CHCHD3 ITPA RPL24 NSUN2 NUBPL SPG11 SNX8 SNAPC5 SRI ERI2 RRNAD1 XAB2 CCAR2 ZSCAN32 FAF2 LSM5 RLF GUCD1 UBE4A NGDN DZANK1 VPS51 NXT1 SLCO4A1 RN7SL1 CLDN12 RMDN3 CD55 TM9SF4 SGSM2 TXLNG SNRPD3 UBN2 SH3YL1 CAAP1 SPINT1 PINX1 SMG5 SDHA SLC25A48 TOM1L2 KIF3A SCAF1 TUBGCP6 THAP11 GCC1 BOD1 LINC00857 PRMT3 CACTIN PTRHD1 LONP1 NAPB RPS3 PYCR2 PARP2 PICK1 TNPO2 ANKS1A HAUS5 FAU PIGO TAF12 SPEF1 IFRD1 FDXR DNAH2 RPSA TM4SF1-AS1 ZNF133 AP5Z1 B3GALNT2 GAK TTLL5 PDSS2 ATG14 DDX55 RUVBL2 ZNF692 ESF1 COX19 LRRC1 TFIP11 RPS28 ATG16L1 WDR18 RANBP1 FAM13A PRCC CCDC127 C7orf50 SEMA4B CPNE1 PARP12 RC3H1 TSN MAN2C1 DAP3 C1orf109 ZNF26 PPP2R5B TRAF4 KCNK5 ANKRD24 NDUFS3 THUMPD1 TIPARP SFSWAP TMEM170A TMEM203 ZNF584 RANGAP1 CTDP1 CD320 TSR1 TOMM22 FBXW9 MKS1 BLOC1S4 TMEM208 BRMS1 NIPA1 KITLG DHRS1 TPCN1 LGR5 BCL2L2 PIGG PTRH1 AGPAT5 NOP56 NEAT1 POLG PLEKHJ1 TMEM52 TMEM175 MTHFSD HDGF CHMP4B NDOR1 RAB11A MVK ZNF317 ETF1 NMT1 C12orf76 PGBD4 SRRM5 ARL6 HOMER1 SHC1 NPDC1 ZNHIT6 PAIP1 MAP3K13 YY1AP1 USP48 SUPT16H FOPNL NAT10 PUS1 DUT IGSF9 TNFSF10 FNIP1 CXXC1 LRRC59 HIRIP3 C4orf36 MAN1B1 GPATCH8 DENND6B RBBP5 NEK9 RPS15A SLC25A16 VAMP8 MAP3K5 ECSIT C1orf226 RAD23A MAP3K11 GTF2H3 MALSU1 SEC23B WSB2 FAM222B NDUFV1 ZDHHC12 NDUFC2 MYPOP GPATCH4 KHSRP ZNF106 COMMD1 MED18 MET VPS18 CBX1 RPS8 METTL1 BCKDHB MORF4L2 CISD1 SNORD46 USP20 TMEM106B NOL10 ROPN1L RPS29 MRPL24 TSEN2 DIAPH1 GSK3B MAGOH STK19 RN7SL832P XRCC1 THAP7 CCT6B ANKRA2 NUP214 SIRT6 HDLBP PSMF1 RRP15 TMEM216 LARP1 RAB27A HIGD2B FAM126A RABGAP1L MAP2K3 RAVER1 HARS2 ARV1 GATC GTPBP10 PURA N6AMT1 WDR89 TOM1 PDCD2L BBS4 CDK5RAP1 CCDC7 GOLGA1 RPL28 RECQL5 SYAP1 COQ4 SAFB2 FZD1 AP1G1 IFT122 STEAP2 BTBD19 MIS18A PPAN NEURL4 EIF3M AIMP1 ZNF805 HAX1 NUP153 PARP9 TK2 ZNF497 CPSF4 TRMT2A ZNF444 ZNF79 FIGNL1 COA3 IST1 ZNF217 ACLY DUS2 LRRC29 PHB SNRPB2 DNAH6 PIH1D1 RPS6KB2 ASXL1 SAMD4B TMEM230 DCAKD IFT172 CDC73 MIR5687 THAP7-AS1 MRPL32 ZNF324 TCF25 ZNF576 NEDD4L FBXO38 PDCD7 MMACHC RPL5 CCT7 PSME3 SRD5A1 NDUFA2 FANCL SRSF9 GORASP2 ADSL SRSF11 MRPS27 ENSA CCDC15 DMAP1 TRIM47 OMA1 TTC30A RPL23 MZT2B KDM4B AFF1 ZNF200 TTC13 GFM2 TARS2 MIR4258 RBM12 WDR5B ALKBH2 CIC ERLIN2 SAP30BP up
## GREB1_TARGET_GENES 0.0010081 0.0051693 0.4370031 2.130600 0 755 ODAM PIK3C2G RNF207 TFF1 ADAP1 PRSS22 DMRT2 TMPRSS3 THSD4 GSPT1 PTPRH DAAM1 TRAF7 DNAH11 PGP ZNF282 SMAD3 FAF1 SNRNP25 POLR3K PLA2G4B WWC1 STARD10 NR1D1 NADK NAV2-AS3 NUMA1 SYTL5 OSBPL2 KIAA0895 SPRED2 TJP2 PRSS27 LIMA1 WDR90 FAM86GP AKAP1 MESP1 EXOSC10 ARID4A LMBR1 SIN3A DGAT2 VEPH1 EPS8 ANKFY1 SMAGP AKT1 STAP2 FREM2 MGRN1 SLC35E1 PPFIA3 OXR1 CDC34 LRG1 EVI5L SPNS2 SSTR5 LINC00511 RTKN FRMD4B DNPEP BCL9L GTPBP3 NFATC2IP CYB561 LINC00479 TBC1D10B CSNK1G2 EPN3 ADAMTSL5 GPRC5A GAS5 CARD10 EPB41L1 KRT8 CCDC159 CCDC40 TFAP2C RASAL1 BCAR1 PLXNB2 MACROD1 MTUS1 KIF21A IQCD PSMG3 LAD1 SLC20A2 ZSWIM1 CDS1 RAPGEFL1 PPP4R1L C1orf21 VILL EPHA1 CHTF18 CYP4F23P CNGB1 RBBP8NL DOK7 CEP170B EPS8L2 DLG5 TMED3 SRI C7orf57 UFSP1 FBRS AK2 SPTSSB IGSF3 NAALADL2 NOP14-AS1 ZMYND8 CHD8 MTMR12 GRHL2 MACC1 ARRDC1 DNMT1 LINC00112 SCAMP4 XXYLT1 ESRP2 LRCH4 KIAA1324 AKAP8L ERP27 OVOL2 KCNH2 TMTC2 PPP1R16A SH3YL1 ZNF823 MPRIP-AS1 ALKBH7 ANKRD11 HDAC7 SPG7 EPN2 TOM1L2 SSR4P1 TMPRSS13 FNIP2 PLAC1 EHF ZFYVE28 CHST12 CELSR1 MIDN SLC2A8 MANEAL ZDHHC1 IFRD1 TPD52L1 PPM1L TTLL5 ZKSCAN1 ABHD17C ANAPC2 CAB39L RHPN1-AS1 RBM47 MAB21L3 TPD52L2 XRCC3 GPR160 PKP3 SRPK1 PAK4 DNASE1 SCIN ABHD2 TNKS1BP1 PHF5A AKAP9 TSPAN1 BDKRB1 KATNB1 RC3H1 NINL TPRN PROM2 TRAPPC2 GATAD2A ANKFN1 CCDC88C GRHL1 SHARPIN MIOS PRR15L TMEM184B RHPN1 TIPARP RFFL MPND DLC1 DCAF15 TJP1 DNM2 STIP1 STX19 HK1 FMN1 DCTN4 RFX1 RHOBTB3 ENC1 PPARD CAPN8 SALL4 RHOC RNF19A NMT1 ZNF689 ADAT3 DNAH3 GRAMD1A URB1 SLC9A8 PPM1H KRT80 IGSF9 RGMB ERBB2 FHDC1 CORO2A C4orf36 GFAP PIWIL4 EPHB4 GIGYF2 ADARB1 CANT1 SMARCD2 KIAA1217 SPAG17 EHMT1 HMGCS1 BCAR3 KCTD11 LCOR WSB2 TBKBP1 AMZ1 PXMP4 CMTR2 KHSRP ZFYVE21 ZSWIM4 LRIG2 LTBP3 UIMC1 POU2F3 CAMTA1 TUBB4B BAIAP3 ATP8B1 IGF2BP1 IFT43 SPPL2B KLHL25 TCIRG1 SULT1A1 RPS6KA2 RCOR3 RARA DNAI1 DDA1 FAM126A GALNT10 C19orf57 PCDH1 MPHOSPH10 SGMS2 PBX1 CHD6 ISOC2 TAZ ASCC2 SSNA1 DAZAP1 JUND RPL27A UTRN SLC25A25 RECQL5 DNMBP BCL3 ATP2A2 ATXN7L1 ABCC11 PAM KCNK1 FBXO24 NFKBIZ ERCC1 COMTD1 RNU6-197P ANXA9 RANBP2 ZNF750 TSPAN9 SLC27A2 RPS6KL1 TLE1 ZNF444 UPF1 HOMEZ SLC25A36 ARID1B UNKL P4HB MCCC2 OSBPL10 MPV17L2 CYTH2 RGMB-AS1 ZNF687 PARD3 YIF1A TMCO3 PROSER2 UMODL1 JUP TCF25 PRKCH FBXO38 TNS1 SLC51B CCT7 TMEM60 INPP4B ZNF860 ZNF574 PCTP RGS3 ALDH3B2 TBC1D16 ENSA ZNF77 TBC1D8 SLC1A5 LINC00885 AP3M2 DOLPP1 KDM5A TMPRSS4 KDM4B KLK6 AFF1 up
## HOXB6_TARGET_GENES 0.0010267 0.0051693 0.4440153 2.130376 0 531 CDK13 EFR3B DNAJA3 TP53BP1 HMOX2 SLC4A2 RFX2 SLTM TTLL4 RPPH1 TULP3 FZR1 INO80 GSS ZBTB17 TMEM222 C16orf46 TPRG1L NMRAL1 PCSK5 EPS8 GUK1 SH2D3A RNF32 WDR73 BST2 PPFIA3 WDR60 CHERP C15orf41 HOXB7 MRPL55 TMEM62 ATP6V0D1 HIP1R GPBP1L1 CHD2 TIGD4 EDEM3 SPAG16 SLC25A51 CDK5 RNPC3 CROCCP2 MACROD2 ABCF2 MST1P2 ELOVL1 UBE2O PSMD3 SRRT FAM220A IQCC NCR3LG1 RSBN1L PCGF1 CHCHD3 TNKS THOC6 FOXA3 FTO MCCC1 ZBTB45 EPS15L1 C12orf75 LRRC56 TIPIN PKN2 WDR55 RSPH3 USP8 NLE1 MVB12A HRAS GANC SRSF1 SH3YL1 PINX1 WEE1 GRPEL1 TUBG1 SYTL2 ZSCAN21 PARP2 TMEM87A TOMM34 CCPG1 HAUS5 MAP2K1 STX12 NIPA2 CBX8 CDK10 TMEM134 ZDHHC16 RETSAT CDNF MKRN1 RSPH1 ABHD2 PCLO AKAP9 KIAA1328 SEMA4B CLCN6 ETNK1 TMEM65 TSN NBPF1 PRMT5 C4orf47 HSPA14 LINC01006 GFOD2 ASCC3 ZNF862 CDK18 TIPARP AP1S1 CEP70 RAD52 ZNF584 IWS1 TMEM144 HSD17B12 CCDC114 RFX1 GCC2 MAPRE3 DLG4 RAB11A PISD RHOC C15orf65 SMG7 FITM2 SRRM5 PPP5C B3GNTL1 AATF TPGS2 U2AF2 CSNK1G1 PPRC1 HEXIM1 FNIP1 ARMC10 MAN1B1 FUS ERBB3 PTPN13 UBAP2L C1orf226 TRAPPC13 RNASEH1 NABP2 RNF41 CTDSPL2 RPL9 EXOC8 CSNK2A1 MAZ TOLLIP SPRTN DNAJC8 CCDC151 ANKHD1-EIF4EBP3 HCFC1R1 TMEM179B MET ANKHD1 UIMC1 RAB3GAP2 RABGEF1 XPR1 ATP8B1 EXOSC5 ABCA7 LSM4 TSEN2 CALCOCO2 DIAPH1 PPA1 CCDC34 B3GAT3 LYAR GATC GOLGA5 SLC12A9 N6AMT1 FAM185A EFNA4 ZMAT5 CHD4 LZTFL1 NF2 ELMOD3 STARD3 C1orf43 WDR62 EFHC1 ZNF277 DNMBP DNAL1 IFT122 BTBD19 HMGB3P22 ERCC1 PREPL EIF3M WDR20 TSGA10 SLC50A1 PRKCSH HOMEZ FDPS NDC1 C14orf119 ZC3H3 MAP3K14 MTHFR PCM1 IFT172 CCDC30 GSDMD RIC8B ZNF576 RPGRIP1L CNOT11 SSBP2 SAE1 STAT2 CDK4 DYNLT1 P4HA1 MRPS27 TBC1D8 ARFIP1 TTC30A UBAC2-AS1 PPP2R1A TMEM143 USP40 C12orf66 ZHX1 WDR35 MTTP ANKRD26 RPF2 COX7C OSER1 CFL1P1 STX6 TTC5 KAZALD1 MAPK10 GMNN SPAG7 ZBTB49 ZNF195 AP1AR KIAA1191 RRM2B COQ6 CNTFR-AS1 IPO11 GADD45G EFEMP2 RPL37 TAF13 FXYD5 CHMP2A DPP8 TCTEX1D4 ALAS1 MRPL27 LARP4 SLC4A1AP TIMELESS KIAA0825 TMEM69 SLC33A1 FADS1 ARPC5L MAGOHB ACADVL OAZ2 EIF3E DHRS7B OCIAD1 MYCBP up
fgsea_plot(fgsea_res$res_c4, pathways_title='C4 cancer', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------- ---------- ---------- ---------- --------- ------------- ----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GCM_TPT1 0.0013495 0.0060721 0.6284799 2.372348 0 59 RPLP0 RPS21 RPLP1 RPL10A RPS3 RPL29 RPS2 RPL18 RPSA RPS28 RPL13A RPL35 RPS14 RPS11 RPL32 RPL3 RPLP2 RPL11 NCL RPL34 RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPL38 RPL4 RPL27A RPL28 RPS9 RPL19 RPL35A EEF2 RPS3A RPS7 RPL27 RPL23A RPL23 CLEC18C RPL14 PPIA RPS16 up
## MORF_AATF 0.0011507 0.0060721 0.5270899 2.336914 0 191 DNAJC11 TP53BP1 SRRM1 MFN2 TRAPPC3 MTOR RNPS1 GTF2A2 GNL2 TXLNA IDH3A BMS1 UBE2I PREP EIF3I EIF6 IDH3B TUFM CLSTN1 NAE1 AIMP2 PSMD3 SRRT XPO6 CLNS1A SNRNP200 NUDC THOP1 DHX38 SDHA PRPF8 KXD1 EIF2B5 IMMT ALDH4A1 HADH ATXN10 RUVBL2 CUL1 WDR18 SSRP1 MTX1 FIBP DAP3 DDX49 RUVBL1 SFSWAP ARFGAP2 KHDRBS1 LRPPRC NONO POLR2C RTCB ETF1 HNRNPAB AATF NCL FUS TRRAP SMARCC2 COQ9 PRKDC RAD23A SGTA DNAJC8 DRG1 SSBP1 SART3 SDR39U1 NELFB DDX39A TCOF1 RALY PABPC4 UBE2L3 PKMYT1 SERBP1 COPS6 TERF2IP EIF3M MMS19 TFAP4 PRKCSH ACLY DDB1 PHB PIN1 CAPRIN1 CYC1 MLEC ADSL CS SERP1 OXA1L SNRPA NUP188 up
## MORF_DDB1 0.0011338 0.0060721 0.5141523 2.321908 0 226 RERE PDXDC1 TP53BP1 PTPRA MFN2 SLC4A2 DOCK3 OTUB1 GNL2 TXLNA UBE3C BMS1 KPNA6 CIB1 EIF6 IDH3B CLSTN1 CSNK1G2 ADAM15 ATXN2L STX3 AHCYL1 PSMD3 ABR SRRT RAC1 PCGF1 XPO6 SNAPC5 SNRNP200 PCGF2 SMC5 TSTA3 SDHA PRPF8 KXD1 MRPL28 EIF2B5 ALDH4A1 PARP2 ATXN2 TOMM34 ACTN4 TTI1 FDXR RUVBL2 SH2B1 CUL1 WDR18 PMS2P3 ATG9A SSRP1 MTX1 DAP3 DDX46 RABGGTA SFSWAP KHDRBS1 LRPPRC OARD1 VAMP3 NCOR2 NONO POLR2C RTCB GOLGA3 PARN HNRNPAB AATF ILVBL BRD3 TRRAP SMARCC2 PRKDC SGTA EHBP1 CSNK2A1 DNAJC8 DRG1 FOXK2 SART3 SDR39U1 NELFB DDX39A STK19 TCOF1 DRAP1 VGLL4 PDAP1 CSNK1D TPR RPRD2 BPHL PKMYT1 WDR62 COPS6 CUL4B TERF2IP MMS19 CPSF4 TFAP4 COX8A PRKCSH HLTF DDB1 PHB PIN1 YIF1A up
## MODULE_139 0.0013175 0.0060721 0.5818473 2.270533 0 76 ARHGEF16 GSE1 MYO6 CYB5A MNX1 ICA1 AGR2 ELF3 MSX2 CDH1 ARHGEF5 KRT8 B3GNT3 TFAP2C FOXA1 PRLR TNFRSF25 OCLN TJP3 SYTL2 EPCAM SLC9A3R1 SYT17 GPR160 PKP3 BDH1 KRT19 PRR15L MAL2 MSI2 MLPH ISOC1 DPYSL5 TP53I11 ERBB3 NEBL UBXN6 SELENBP1 KRT18 SPINT2 ANXA9 NSUN7 MUC1 CMAHP ST3GAL5 up
## MORF_TPT1 0.0012788 0.0060721 0.5606473 2.254446 0 92 LYPLA2 RPL13 RPLP0 RPS5 RPL24 RPLP1 RPL10A RPL22 RPS3 RPL29 RPL18A FAU RPL18 RPS12 RPL13A RPS14 RPS13 RPS11 BTF3 RPL32 RPL3 RPL12 RPLP2 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A RPS20 RPL38 JUND RPL4 RPS27 RPL27A RPL28 RPS9 RPL19 EEF2 ZFPL1 RPS4X ARAF RPS3A RPS7 EEF1B2 UBC RPL5 RPL27 RPL23A RPL23 RPL30 SRP14 PPIA RPS16 COX7C up
## MORF_HDAC2 0.0011161 0.0060721 0.4876015 2.231952 0 247 DNAJC11 ZMYM4 AKR7A2 SRRM1 EDC4 TRAPPC3 DOCK3 GTF2A2 GNL2 TXLNA DDX19A CDK11A BMS1 HDAC1 PREP SDHB EIF3I TARDBP UQCRC2 CHERP TUFM NAE1 AIMP2 DDX19B TFDP1 PSMB2 XPO6 CLNS1A SNRNP200 DFFA NUDC TNPO3 DNMT1 TM9SF4 SRSF1 NELFA SDHA KRIT1 PRPF8 KXD1 TCERG1 IMMT HADH ATXN10 IFRD1 RNPEP MAP2K2 EI24 RUVBL2 CUL1 RANBP1 SSRP1 FIBP ILF3 DDX46 KHDRBS1 FBXW11 GNB1 LRPPRC RNF126 HSPA9 NONO POLR2C RTCB ETF1 FAM120A HNRNPAB AATF PPM1G DUT FUS TXNL4A COQ9 PRKDC RAD23A SGTA NDUFV1 DNAJC8 KHSRP DRG1 SON SSBP1 SART3 DGUOK SLBP ZWINT VDAC1 CHAF1A MAGOH DDX39A GOT2 MFAP1 STK24 XPOT DGKZ PABPC4 EIF4EBP2 SERBP1 THOC2 EIF3M MMS19 TFAP4 HNRNPR RPA1 NDUFC1 SEC24C ZNF131 CCT5 MLEC RAD54L MRPS27 CS SERP1 SNRPA NUP188 ARFGEF1 ANP32A RBMX up
## MORF_TERF2IP 0.0012594 0.0060721 0.5400823 2.219878 0 108 SLC9A1 TP53BP1 UBN1 MFN2 OTUB1 CLSTN1 CUX1 DNPEP NFATC2IP ATXN2L SRRT XPO6 SNRNP200 CHD8 SMC5 DHX38 ALDH4A1 MKRN1 SH2B1 SFSWAP ARFGAP2 KHDRBS1 OARD1 RTCB RAB11A PARN HTATSF1 AATF FOXJ3 BRD3 SMARCC2 DNAJC8 DRG1 SDR39U1 NELFB EAPP STK19 CSNK1D TPR RPS27A RPRD2 COX7A2L NUBP1 COPS6 CNOT4 TERF2IP CPSF4 TFAP4 IST1 PRKCSH SLC25A36 DDB1 PHB STK38 up
## MORF_ARAF1 0.0013263 0.0060721 0.5708441 2.217011 0 73 SLC9A1 CNTN1 LMTK2 OTUB1 PDPK1 FZR1 LYPLA2 IGSF9B IGHMBP2 PML BTBD2 ADAM15 TUB SLC9A3R2 PCGF2 CACTIN ALDH4A1 HSF4 SLC12A4 MTX1 MAN2C1 RABGGTA DHRS1 GRM4 GTF2F1 RPLP2 HMG20B MVK CIZ1 LPAR2 PVT1 ACKR2 GPR35 NELFB STK19 RASSF7 COPS6 ATXN7L1 CNOT4 ZFPL1 PRKCSH ARAF up
## MORF_RAF1 0.0012642 0.0060721 0.5381361 2.210384 0 107 UBN1 SRRM1 MFN2 OTUB1 UBE2I IDH3B CUX1 DNPEP NFATC2IP CSNK1G2 ATXN2L ABR SRRT RAC1 XPO6 SNRNP200 DHX38 JTB PRPF8 KXD1 MRPL28 RNF4 MKRN1 SFSWAP ARFGAP2 KHDRBS1 FBXW11 NONO POLR2C RTCB HTATSF1 ETF1 HNRNPAB FOXJ3 BRD3 DNAJC8 DRG1 PPP2R5E NELFB DDX39A STK19 PDAP1 CSNK1D TPR RPRD2 COX7A2L TERF2IP COX8A IST1 PRKCSH SLC25A36 DDB1 up
## MORF_RAD23A 0.0010989 0.0060721 0.4761711 2.207563 0 304 DNAJC11 AKR7A2 SRRM1 EDC4 EIF3B TRAPPC3 DOCK3 TBL3 RNPS1 GTF2A2 DDX19A HDAC1 PREP PIEZO1 SDHB EIF3I TARDBP MGRN1 IDH3B CHERP TUFM AP3D1 DDX19B SF3A2 NDUFS4 TFDP1 PSMB2 DHCR7 SREBF2 PARK7 SNRNP200 AK2 NUDC TNPO3 THOP1 RSL1D1 DDOST DNMT1 DHX38 SRSF1 JTB DEAF1 SDHA CTBP1 KRIT1 PRPF8 KXD1 IMMT HADH ATXN10 IFRD1 RNPEP MAP2K2 EI24 CLTA RUVBL2 PPIE GNB2 NUP205 FARSA PRRC2C FIBP ILF3 DDX49 TRIM28 NDUFS3 KHDRBS1 GNB1 LRPPRC RNF126 HSPA9 NONO RTCB HDGF FAM120A HNRNPAB AATF SF3B2 PPM1G NCL DUT FUS TXNL4A PRKDC RBBP4 UBAP2L SMARCD2 RAD23A CIAO1 DHX15 NDUFV1 DNAJC8 KHSRP DRG1 LMNB2 ACOT7 TOMM20 SSBP1 GLO1 DGUOK SLBP ZWINT LSM4 DIAPH1 VDAC1 MAGOH DDX39A HNRNPUL1 UQCRH SF3A1 GOT2 MFAP1 XPOT DGKZ LARP1 NUDT1 NDUFS5 PABPC4 EIF4EBP2 CHD4 UBE2L3 SLC3A2 MCM3 HAX1 RPIA HNRNPR ACLY UBAC1 NDUFS8 NDUFC1 TYMS SEC24C ZNF131 CYC1 CCT5 CCT7 SRSF9 CS SLC1A5 PPIG SERP1 IMPDH1 SNRPA PPP2R1A NUP188 ANP32A up
## MORF_BUB3 0.0011173 0.0060721 0.4790841 2.190781 0 243 DNAJC11 AKR7A2 SRRM1 EDC4 TRAPPC3 DOCK3 GTF2A2 HDAC1 SDHB EIF3I TARDBP CHERP TUFM NAE1 DDX19B SF3A2 NDUFS4 TFDP1 PSMB2 SREBF2 PARK7 SNRNP200 AK2 NUDC TNPO3 THOP1 RSL1D1 DDOST DNMT1 SRSF1 SDHA PRPF8 KXD1 IMMT HADH ATXN10 IFRD1 RNPEP FEN1 MAP2K2 EI24 RUVBL2 PPIE SSRP1 FIBP ILF3 DAP3 DDX49 TRIM28 NDUFS3 KHDRBS1 GNB1 RANGAP1 LRPPRC HSPA9 NONO HNRNPAB AATF SF3B2 PPM1G NCL DUT FUS TXNL4A PRKDC RBBP4 UBAP2L RAD23A SRM NDUFV1 DNAJC8 KHSRP DRG1 PCNA LMNB2 SSBP1 NASP GLO1 DGUOK SLBP ZWINT LSM4 VDAC1 CHAF1A HNRNPUL1 UQCRH GOT2 STK24 XPOT NUDT1 NDUFS5 PABPC4 EIF4EBP2 UBE2L3 MCM3 SERBP1 HAX1 HNRNPR ACLY NDUFC1 TYMS SEC24C CYC1 CCT5 CCT7 SRSF9 MRPS27 CS SLC1A5 SERP1 IMPDH1 SNRPA UBE2S PPP2R1A NUP188 ANP32A RBMX up
## MORF_RAD54L 0.0012804 0.0060721 0.5455507 2.179846 0 88 DNAJC11 SRRM1 GTF2A2 GNL2 TXLNA IDH3A CDK11A BMS1 PREP PWP2 EIF3I NAE1 TFDP1 XPO6 DFFA NUDC TNPO3 THOP1 DNMT1 PRPF8 IMMT HADH RUVBL2 SRPK1 SSRP1 DDX46 SFSWAP LRPPRC TRRAP PRKDC SGTA KHSRP SSBP1 ZWINT CHAF1A DDX39A GOT2 TCOF1 PABPC4 PKMYT1 THOC2 MZF1 MMS19 ZNF131 MLEC RAD54L CS NUP188 RFC1 MCFD2 SAFB ALG3 CEBPZ XPO7 POLR2A up
## MORF_PRKAG1 0.0011416 0.0060721 0.4882107 2.179710 0 203 PDXDC1 TP53BP1 MFN2 SLC4A2 DOCK3 OTUB1 GNL2 TXLNA UBE3C BMS1 PMM2 KPNA6 CIB1 EIF3I CLSTN1 CSNK1G2 ADAM15 ATXN2L AHCYL1 PSMD3 ABR SRRT RAC1 PCGF1 XPO6 SNRNP200 TSTA3 SDHA PRPF8 KXD1 MRPL28 EIF2B5 ALDH4A1 PARP2 ATXN2 TOMM34 RUVBL2 SH2B1 MTX1 DAP3 SFSWAP KHDRBS1 FBXW11 LRPPRC OARD1 VAMP3 NCOR2 NONO POLR2C RTCB RPS6KA3 GOLGA3 PARN AATF ILVBL BRD3 GLG1 COQ9 SGTA EHBP1 CSNK2A1 DNAJC8 DRG1 SART3 SDR39U1 NELFB STK19 TCOF1 DRAP1 VGLL4 CSNK1D TPR RPRD2 BPHL PKMYT1 COPS6 CUL4B TERF2IP MZF1 MMS19 CPSF4 TFAP4 COX8A PRKCSH HLTF DDB1 PHB YIF1A MPST MLEC P4HA1 CS LSM12 SERP1 PPP2R1A NUP188 INTS10 BAHD1 ST13 CETN3 RFC1 FANCG MCFD2 SLC25A11 CAPZB RAF1 BECN1 RPN2 ALG3 NIPSNAP1 CALM2 XPO7 EML3 POLR2A TCEA1 AFG3L2 NSL1 MYCBP PSMD2 PLIN3 BRD8 up
## MORF_GNB1 0.0010965 0.0060721 0.4688974 2.169306 0 274 PTPRA AKR7A2 SRRM1 EDC4 TRAPPC3 DOCK3 RNPS1 GTF2A2 TXLNA DDX19A HDAC1 TRAK1 SDHB EIF3I TARDBP MGRN1 IDH3B GUSB TUFM CLSTN1 PTBP1 ATXN2L AP3D1 DDX19B SF3A2 AHCYL1 NDUFS4 PSMB2 SREBF2 PARK7 XPO6 SNRNP200 AK2 NUDC TNPO3 THOP1 DDOST DNMT1 JTB SDHA CTBP1 PRPF8 KXD1 IMMT HADH ATXN10 IFRD1 RNPEP RNF4 MAP2K2 EI24 GAK RUVBL2 EIF3D PPIE GNB2 TAX1BP1 PRRC2C ILF3 DDX49 RMND5A TRIM28 KHDRBS1 FBXW11 CBFB GNB1 LRPPRC VAMP3 NCOR2 NONO POLR2C RTCB HNRNPAB PPM1G NCL DUT FUS TXNL4A SMARCC2 PRKDC RBBP4 RAD23A MAP3K11 NDUFV1 DNAJC8 SUGP2 KHSRP TOMM20 SSBP1 DGUOK SLBP DIAPH1 VDAC1 HNRNPUL1 UQCRH SF3A1 GOT2 STK24 DGKZ NUDT1 NDUFS5 PABPC4 EIF4EBP2 CHD4 UBE2L3 EIF3M HAX1 RPIA HNRNPR PIN1 ATF4 ASXL1 CAPRIN1 NDUFC1 TYMS SEC24C ZNF131 CCT7 MLEC SRSF9 CS SERP1 IMPDH1 OXA1L SNRPA UBE2S PPP2R1A NUP188 ANP32A SRP14 RBMX up
## MORF_NME2 0.0011976 0.0060721 0.5079592 2.165475 0 141 OTUB1 LYPLA2 UBE2I GNAS DNPEP RPL13 TSR3 RPLP0 ENO1 RPS5 RPL24 EEF1A2 UBA1 JTB RPS3 SNRPB RPL18A FAU RPL18 RPS12 RPL13A RPL35 RPS14 RPS13 RPS11 BTF3 RPL32 RPL12 RPLP2 HDGF RPL11 C9orf16 RPL34 RPS15A STOML2 RPL9 PSMC1 DRG1 RPS23 RPS8 RPS29 SUMO3 HINT1 PDAP1 RPL31 RALY RPS27A COX7A2L MRPL23 RPS20 SSNA1 RPL38 RPS27 RPL27A SSR2 HSP90AB1 RPS9 RPL19 COPS6 EEF2 EEF1D COX8A RPS4X COX4I1 RPS3A RPS7 RPL36AL UBC CYC1 CCT7 RPL27 NDUFA2 RPL23A RPL30 SRP14 PPIA RPS16 COX7C SPAG7 BANF1 COX5B SNRPE CALM2 RPL8 PSMB4 ALDOA TBCB RPL15 up
## MORF_DAP3 0.0011442 0.0060721 0.4890042 2.164992 0 179 TRAPPC3 TBL3 UBE2I EIF3I EIF6 IDH3B TUFM DNPEP AHCYL1 PSMB2 PARK7 CLNS1A SNRNP200 UBA1 DDOST SLC25A5 JTB SDHA CTBP1 KXD1 EIF2B5 SNRPB ATXN10 SETD3 RUVBL2 FIBP DAP3 DDX49 NDUFS3 ARFGAP2 KHDRBS1 FBXW11 LRPPRC NONO RTCB FAM120A HNRNPAB AATF NCL BRD3 SMARCC2 STOML2 NDUFV1 DNAJC8 DRG1 DGUOK SDR39U1 NELFB HNRNPUL1 UQCRH VGLL4 PDAP1 RALY COX7A2L MRPL23 UBE2L3 SSR2 HSP90AB1 COPS6 EIF3M HAX1 COX8A FDPS ACLY DDB1 COX4I1 PIN1 CYC1 CCT7 SRSF9 CS SERP1 IMPDH1 OXA1L SNRPA PPP2R1A NUP188 SRP14 COX7C CCT3 CAPZB BANF1 COX5B SNRPE RPN2 EIF2B4 ALG3 NIPSNAP1 CALM2 XPO7 DDT PSMB4 TBCB IK TCEA1 AFG3L2 PSMD2 BRD8 ANAPC5 STARD7 POLR2H POLR2I CCT2 PIGC PPP1R11 HNRNPA2B1 RAN ILF2 SPCS2 PSMB1 HUWE1 PSMB3 COX6B1 ATP6V1F up
## GNF2_EIF3S6 0.0012547 0.0060721 0.5245395 2.164439 0 110 SRRM1 RPL13 RPS21 RPL24 RPL10A RPL22 EIF3L RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA EIF3D SLC7A5P1 RPL36 RPS12 RPS28 RPL13A RPL35 DAP3 RPS14 RPS13 BTF3 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 TAF1D RPL9 RPS23 SRSF7 RPS8 RPS29 RPL31 UBA52 RPS20 RPL38 RPL4 RPL27A RPL28 RPS9 RPL19 RPL35A AIMP1 RPS4X RPS3A RPS7 RPL36AL EEF1B2 PMPCB RPL5 RPL27 RBBP6 RPL23A RPL23 POLR1D RPL30 ST13 RPL14 RPS16 RPL41 COX7C up
## MORF_PRKDC 0.0011601 0.0060721 0.4946990 2.162950 0 166 DNAJC11 AKR7A2 SRRM1 GTF2A2 GNL2 TXLNA IDH3A CDK11A BMS1 PWP2 EIF3I NAE1 DDX19B TFDP1 PSMD3 SREBF2 XPO6 SNRNP200 DFFA AK2 NUDC TNPO3 THOP1 DNMT1 DEAF1 PRPF8 KXD1 IMMT HADH ATXN10 RNPEP EI24 RUVBL2 PPIE SRPK1 WDR18 SSRP1 DDX46 RUVBL1 KHDRBS1 GNB1 LRPPRC NONO AATF DUT TRRAP TXNL4A COQ9 PRKDC RAD23A DNAJC8 KHSRP SSBP1 SLBP ZWINT DIAPH1 CHAF1A DDX39A GOT2 TCOF1 NUDT1 PABPC4 PKMYT1 MCM3 MZF1 MMS19 RPIA TFAP4 HNRNPR DDB1 PIN1 TYMS ZNF131 CCT5 MLEC RAD54L MRPS27 CS SNRPA NUP188 ANP32A MCFD2 SAFB ALG3 PSMA1 CEBPZ XPO7 POLR2A NPM3 CNOT1 TCEA1 AFG3L2 PSMD2 BRD8 ANAPC5 BMI1 STARD7 SEC63 PABPN1 FH HNRNPA2B1 PGM1 up
## MORF_CSNK2B 0.0011161 0.0060721 0.4706531 2.161655 0 258 RER1 AKR7A2 SLC4A2 EIF3B TRAPPC3 DOCK3 TBL3 HDAC1 SDHB EIF3I TARDBP GGCT UQCRC2 CHERP TUFM ALG8 AP3D1 DDX19B SF3A2 PRMT1 NDUFS4 RAC1 PSMB2 DHCR7 TUBB2A PARK7 SNRNP200 NDUFAB1 UBA1 DDOST SRSF1 JTB SDHA CTBP1 KXD1 ATXN10 COMMD4 IFRD1 RNPEP FEN1 MAP2K2 EI24 CLTA RUVBL2 GNB2 EIF3C PRRC2C FIBP MAEA ILF3 DAP3 DDX49 TRIM28 NDUFS3 KHDRBS1 GNB1 ATIC HSPA9 NONO HDGF SMG7 DAP FAM120A HNRNPAB SF3B2 PPM1G FUS RBBP4 UBAP2L SMARCD2 RAD23A SYPL1 NDUFV1 DRG1 PCNA LMNB2 PDCD6 ACOT7 SSBP1 GLO1 DGUOK LSM4 VDAC1 HNRNPUL1 UQCRH EIF4G1 MBTPS1 SF3A1 MFAP1 PTOV1 PDAP1 LARP1 RALY COA1 NDUFS5 CHD4 UBE2L3 SNRPD2 SLC3A2 HAX1 ACLY COX4I1 NDUFS8 YWHAE NDUFC1 SEC24C CYC1 CCT5 LSS CCT7 CDK4 SRSF9 CS SLC1A5 IMPDH1 SNRPA RBM14 PPP2R1A up
## MORF_SOD1 0.0011161 0.0060721 0.4708434 2.155244 0 247 GSPT1 PGRMC1 AKR7A2 SLC4A2 EIF3B TRAPPC3 DOCK3 TBL3 ETFA EIF3I TARDBP GGCT UQCRC2 CHERP TUFM CFDP1 ALG8 AIMP2 PRMT1 RAC1 PSMB2 PARK7 CLNS1A SNRNP200 NDUFAB1 NUDC PSMA3 SRSF1 SDHA KXD1 ATXN10 IFRD1 FEN1 MAP2K2 EI24 RUVBL2 EIF3C FIBP ILF3 DDX49 TRIM28 NDUFS3 KHDRBS1 FBXW11 LRPPRC ATIC HSPA9 UTP18 NONO SMG7 DAP FAM120A HNRNPAB TPGS2 SF3B2 FAM20B PPM1G HSBP1 FUS UBAP2L SMARCD2 RAD23A STOML2 SYPL1 NDUFV1 PSMC1 DRG1 PCNA PDCD6 ACOT7 MORF4L2 SSBP1 SART3 GLO1 DGUOK LSM4 VDAC1 MAGOH UQCRH MFAP1 XPOT LARP1 TMEM106C COA1 SEC61G NDUFS5 MAML1 EBAG9 UBE2L3 SLC3A2 HAX1 FDPS ACLY COX4I1 RPA1 NDUFS8 YWHAE NDUFC1 CYC1 CCT5 LSS CCT7 CDK4 SRSF9 CS ENSA up
## MORF_DNMT1 0.0012690 0.0060721 0.5277214 2.154452 0 103 DNAJC11 SRRM1 GTF2A2 CDK11A EIF3I TARDBP NAE1 DDX19B TFDP1 SREBF2 SNRNP200 NUDC TNPO3 DNMT1 SRSF1 PRPF8 KXD1 TCERG1 IMMT HADH SF3A3 RUVBL2 PPIE SRPK1 SSRP1 KHDRBS1 CBFB GNB1 LRPPRC EBNA1BP2 NONO PPM1G DUT FUS TRRAP TXNL4A PRKDC RAD23A KHSRP LMNB2 SSBP1 NASP SLBP ZWINT CHAF1A GOT2 NUDT1 PABPC4 MCM3 RPIA HNRNPR TYMS ZNF131 CCT5 RAD54L MRPS27 CS SNRPA NUP188 ANP32A up
## MORF_UBE2N 0.0012804 0.0060721 0.5366686 2.140080 0 87 SRRM1 EDC4 DDX19A HDAC1 SDHB TARDBP CHERP TUFM DDX19B PARK7 SNRNP200 SRSF1 KXD1 ATXN10 IFRD1 CTCF PRRC2C ILF3 DDX49 TRIM28 NDUFS3 KHDRBS1 HSPA9 NONO HNRNPAB SF3B2 PPM1G FUS UBAP2L RAD23A DHX15 NDUFV1 SLBP MAGOH SF3A1 CHD4 UBE2L3 up
## GNF2_FBL 0.0012136 0.0060721 0.5038451 2.135541 0 133 SRRM1 POLR3E HDAC1 UBE2I TARDBP RPL13 RPS21 NAE1 RPL24 SNRNP200 SNRPD3 SRSF1 RPL10A SF1 RPL22 EIF3L TCERG1 RPS3 RBM15 RPL29 RPS2 RPSA EIF3D SLC7A5P1 RPL36 RPS12 RPL13A RPL35 DAP3 HSPA14 KHDRBS1 BTF3 RPL32 RPL3 RPL12 NONO RPS15 NCL RRP1B TAF1D DHX15 RPL9 RPS23 SRSF7 RPS8 RPS29 HINT1 RPS20 RPL38 RPL4 RPL28 SNRPD2 RPL19 RPL35A AIMP1 HNRNPR RPS4X NSUN5 RPS7 EEF1B2 PMPCB RPL5 RPL27 RBBP6 RPL23A PPIH POLR1D RBM12 RBMX ST13 RPL14 PPIA RPS16 SRSF10 COX7C HNRNPF SNRPE UTP3 RPL37 RPL8 RPL15 EIF3E NOC3L APEX1 EIF3H NOL11 PABPN1 HNRNPA2B1 LSM7 up
## GCM_NF2 0.0011013 0.0060721 0.4594398 2.120613 0 267 ZNF12 GSPT1 ZDHHC4 TRAF7 MFN2 URGCP NUMA1 OSBPL2 CLEC16A FAN1 VPS53 ADPRHL2 LIG3 TBC1D22B INTS5 SIN3A PREP KPNA6 MAPK8IP1 EXOSC6 TUBGCP4 IQCK KIAA2013 EVI5L SETD1A TP73-AS1 ARFGAP1 EMC8 TBC1D10B SCAMP2 PACS2 MAPK8IP3 MYO9A RNF216 DHCR7 ASB6 XPO6 SNRNP200 EPS15L1 JKAMP KLHL17 RMDN3 TRPC4AP B4GALT2 BRD9 STAMBP SMG5 VEZT PRPF8 C16orf72 SLC35B2 DHX37 TOX4 TNPO2 POLDIP3 ZFR HECTD1 ZNF133 GMEB2 HGS SH2B1 CHAMP1 DBNL RMND5B UBQLN4 ACTR10 GGT7 ERAL1 TADA2B MKS1 MEPCE AARS2 RABIF BCL2L1 ASH1L FOXJ3 CIAPIN1 CIZ1 TTC17 RNF41 WSB2 SUMF2 EHBP1 ATXN7L3 LRIG2 MSL1 RABGEF1 NSUN5P1 STRN4 NUP133 PRRC2B TMEM106B AAR2 ZER1 ANKRA2 GORASP1 RALGPS1 PTCD3 DCUN1D3 BABAM1 EIF4EBP2 NF2 COPS6 KLHL12 RTBDN FN3KRP C2CD5 ALKBH5 WDR33 IFT52 VRK3 HNRNPR WDR70 SAMD4B MTCH2 PSME3 NAA30 NCLN ANKRD40 TMEM245 POGZ WSB1 CS SAP130 METTL17 PPIG MRPL10 GFM2 COQ10A TINF2 CHD9 BAHD1 MMAB ASCC1 SPTLC1 TUT1 ATG4B APMAP KIAA1191 TBC1D14 SNX33 SAFB GPBP1 AP2A1 WDR19 PIP4K2B TM9SF3 DDX47 DENR FOXO3 VPS26B OCIAD1 PATL1 ANAPC5 ZNF644 KLHL18 AMMECR1L PHAX IPO5 up
## MORF_FBL 0.0012092 0.0060721 0.5019737 2.120190 0 129 EIF3B DOCK3 TBL3 RNPS1 UBE2I EIF3I TARDBP IDH3B TUFM SF3A2 PRMT1 PSMB2 PARK7 CLNS1A RSL1D1 DDOST JTB RPL10A KXD1 SNRPB ATXN10 FAU RUVBL2 AHCY EIF3C FIBP ILF3 DDX49 TRIM28 NDUFS3 KHDRBS1 BTF3 NONO HDGF HNRNPAB PPM1G NCL FUS RBBP4 EIF3G RAD23A NDUFV1 DRG1 PCNA TOMM20 SSBP1 LSM4 HNRNPUL1 UQCRH SUMO3 PDAP1 RALY COA1 NUDT1 UBE2L3 HSP90AB1 SNRPD2 SERBP1 up
## MORF_PHB 0.0012330 0.0060721 0.5105890 2.119123 0 113 TP53BP1 MFN2 OTUB1 GNL2 IDH3A BMS1 IGSF9B CIB1 EIF6 ADAM15 PSMD3 SRRT PCGF1 XPO6 PCGF2 TSTA3 PRPF8 MRPL28 ALDH4A1 TOMM34 SLC12A4 FDXR SH2B1 WDR18 MTX1 RABGGTA SFSWAP ERAL1 RTCB HMG20B PARN AATF ILVBL BRD3 MCRS1 DNAJC8 DRG1 SDR39U1 NELFB STK19 TCOF1 CSNK1D TPR RPRD2 BPHL PKMYT1 WDR62 COPS6 TERF2IP CPSF4 TFAP4 PRKCSH DDB1 PHB MPST MLEC CS LSM12 ELK1 NUP188 BAHD1 up
## MORF_IKBKG 0.0012136 0.0060721 0.5027158 2.117679 0 126 SLC9A1 CNTN1 OTUB1 CRCP DIP2C IGSF9B IFT140 IGHMBP2 CIB1 HMGXB3 ST14 MOK FAM189A2 PML ZNF592 ADAM15 TUB PCGF1 MPP2 TSTA3 ALDH4A1 HSF4 SLC12A4 FDXR SETD1B SH2B1 KHNYN PMS2P3 MTX1 RABGGTA SFSWAP DHRS1 VAMP3 GTF2F1 HMG20B MVK PARN SIK3 CAMSAP1 ILVBL MCRS1 LDB1 PVT1 CSNK2A1 PITPNM1 GPR35 PTPN9 NELFB CAMK2B SLC6A9 TCOF1 CSNK1D RPRD2 RASSF7 MCM3AP PKMYT1 WDR62 COPS6 CNOT4 ADAMTSL2 ZFPL1 PRKCSH ARAF DDB1 PHB RPS6KB2 up
## MORF_RAD23B 0.0011862 0.0060721 0.4892780 2.115178 0 157 GSPT1 PGRMC1 RER1 PSMC6 TRAPPC3 ETFA COG4 GGCT CFDP1 ALG8 DNPEP CRK PRMT1 SEPHS2 RAC1 PSMB2 USP10 NDUFAB1 RUSC1 UBA1 UBE4A MAD2L1BP PSMA3 SDHA PSMC3 BAG5 MAPK6 KHDRBS1 FBXW11 HSPA9 EIF2B2 UTP18 SMG7 DAP FAM120A HNRNPAB PSMB5 TPGS2 SF3B2 FAM20B RAB9A HSBP1 UBAP2L ADAR STOML2 SYPL1 RFK PSMC1 PDCD6 MORF4L2 SSBP1 SART3 PDAP1 TMEM106C COA1 HARS2 SEC61G MAML1 EBAG9 ATP2A2 PSMC4 UBR5 RPP38 COX4I1 RPA1 DPM1 RPL36AL YWHAE CYC1 LSS up
## MORF_XRCC5 0.0011416 0.0060721 0.4724746 2.112648 0 209 DNAJC11 PTPRA AKR7A2 SRRM1 TRAPPC3 DOCK3 RNPS1 GTF2A2 TXLNA DDX19A HDAC1 UBE2I SDHB EIF3I TARDBP MGRN1 IDH3B TUFM PTBP1 NAE1 AP3D1 DDX19B NDUFS4 SREBF2 PARK7 SNRNP200 NUDC THOP1 DNMT1 SRSF1 JTB CTBP1 PRPF8 KXD1 TCERG1 IMMT HADH ATXN10 IFRD1 RNPEP RUVBL2 EIF3D PPIE WDR18 SSRP1 FIBP DAP3 DDX49 KHDRBS1 CBFB GNB1 LRPPRC NONO HNRNPAB AATF PPM1G NCL DUT DHX9 FUS TRRAP TXNL4A SMARCC2 COQ9 PRKDC RAD23A NDUFV1 DNAJC8 TOMM20 SSBP1 SLBP DIAPH1 CHAF1A HNRNPUL1 UQCRH STK24 NUDT1 NDUFS5 PABPC4 EIF4EBP2 UBE2L3 EIF3M HAX1 RPIA HNRNPR ACLY PIN1 TYMS CCT7 MLEC SRSF9 CS IMPDH1 SNRPA NUP188 SNRNP70 ANP32A SRP14 up
## MORF_GSPT1 0.0013966 0.0060721 0.5944557 2.105830 0 44 GSPT1 EIF3B GGCT ALG8 PRMT1 FEN1 RNF126 ATIC HSPA9 SMG7 MRFAP1L1 HNRNPAB SF3B2 PPM1G UBAP2L TOMM40 ACOT7 SSBP1 VDAC1 MAGOH EIF4G1 MFAP1 LARP1 up
fgsea_plot(fgsea_res$res_c5, pathways_title='C5 GO genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ---------------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GO_RIBOSOME_BIOGENESIS 0.0011074 0.0162793 0.5301479 2.440585 0 259 NOC2L MRPL20 TBL3 NOB1 GNL2 MRTO4 NOM1 EXOSC10 NIP7 BMS1 RPUSD1 ERI1 UTP14A ERI3 PWP2 EIF6 EXOSC6 SBDS NOP2 NOC4L PES1 MYBBP1A FAM207A MDN1 RRN3 TSR3 METTL16 NSUN4 RPLP0 RPS21 ISG20L2 RPP25 NOL9 MTG2 GEMIN4 NOP14 RPUSD2 RPLP0P6 RPS5 RPL24 MRPS2 RRNAD1 WDR55 NGDN XRN2 RSL1D1 NLE1 DDX51 KRI1 DDX31 VCX RRP9 RPL10A NOL6 DHX37 SART1 RPS2 BOP1 RPSA DDX27 ESF1 RPS28 WDR18 TFB2M RRP1 RPL35 NOLC1 DDX49 NSUN3 THUMPD1 ERAL1 DROSHA TSR1 RPS14 RRP7A LAS1L IMP3 TRMT112 RPL3 EBNA1BP2 NOP56 DDX56 RPL12 UTP18 PELP1 NUP88 RPS15 RPL11 GTPBP4 ZNHIT6 AATF URB1 MRPL11 NAT10 NVL RRP1B POP7 RRP8 MRPS11 MALSU1 UTP20 WDR3 RPS8 METTL15 EXOSC5 EXOSC2 HEATR1 NOL10 URB2 DDX54 RRP15 DDX28 RRS1 LYAR GTPBP10 MPHOSPH10 RBFA NAF1 IMP4 RPL38 RPS27 RPS9 RPL35A CUL4B PPAN HEATR3 DDX10 TSC1 MRPS7 RPP38 NSUN5 MPV17L2 UTP6 PIH1D1 RPS7 PAK1IP1 up
## GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 0.0012077 0.0162793 0.5819252 2.418956 0 114 GSPT1 RNPS1 HELZ2 EXOSC10 RPL13 SMG1 RPLP0 RPS21 RPS5 RPL24 RPLP1 SMG5 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A UPF3B RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 SMG7 PARN ETF1 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 MAGOH EIF4G1 CTIF RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 UPF1 RPS4X SMG6 RPS3A RPS7 RPL5 DHX34 RPL27 RPL23A RPL23 RPL30 PPP2R1A RPL14 RPS16 RPL41 up
## GO_NCRNA_PROCESSING 0.0010799 0.0162793 0.5142387 2.395183 0 325 TYW1 SMAD3 PUSL1 CTU2 TBL3 POLR3K NOB1 MTFMT MRTO4 EXOSC10 BMS1 INTS5 RPUSD1 ERI1 UTP14A ERI3 PUS7 TRIT1 PWP2 METTL3 EXOSC6 SBDS NOP2 NOC4L INTS1 TRPT1 TRMT61A TSEN54 PES1 FAM207A MDN1 TSR3 GTPBP3 METTL16 NSUN4 RPS21 TRMU ISG20L2 RPP25 NOL9 CTU1 GEMIN4 NOP14 INTS4 SEPHS2 RPUSD2 SRRT ADAT1 NSUN2 RRNAD1 WDR55 NGDN XRN2 RSL1D1 TP53RK DDX51 TRMT1 KRI1 DUS3L TRMT11 DUS1L RRP9 TRMT5 RPL10A TARBP1 NOL6 TRMT12 DHX37 SART1 RPS2 BOP1 DDX27 ESF1 RPS28 WDR18 TFB2M RRP1 RPL35 NOLC1 DDX49 NSUN3 THUMPD1 AGO3 DROSHA TSR1 RPS14 RRP7A TRMT6 LAS1L IMP3 TRMT112 EBNA1BP2 DGCR8 NOP56 DDX56 AARS2 UTP18 PELP1 RTCB TRMT44 RPS15 RPL11 PARN ANKRD16 CSTF2 ZBTB8OS ADAT3 GTPBP4 ZNHIT6 URB1 LCMT2 NAT10 PUS1 NVL USB1 RRP1B POP7 RRP8 ADAR MRPS11 UTP20 WDR3 AGO1 RPS8 METTL15 AGO4 METTL1 TRDMT1 EXOSC5 EXOSC2 HEATR1 NOL10 TSEN2 RNF113A RPUSD4 DDX54 RRP15 RRS1 KTI12 LYAR MPHOSPH10 RBFA MOCS3 NAF1 FARS2 IMP4 CDK5RAP1 RPS27 RPS9 AGO2 SEPHS1 RPL35A DDX10 GRSF1 RPP38 CPSF4 DUS2 PUS10 NSUN5 UTP6 INTS7 PIH1D1 RPS7 up
## GO_RRNA_METABOLIC_PROCESS 0.0011468 0.0162793 0.5257692 2.342771 0 195 TBL3 NOB1 MRTO4 EXOSC10 BMS1 RPUSD1 ERI1 UTP14A ERI3 PWP2 EXOSC6 SBDS NOP2 NOC4L PES1 FAM207A MDN1 TSR3 METTL16 NSUN4 RPS21 ISG20L2 RPP25 NOL9 GEMIN4 NOP14 RPUSD2 RRNAD1 WDR55 NGDN XRN2 RSL1D1 DDX51 KRI1 RRP9 RPL10A NOL6 DHX37 SART1 RPS2 BOP1 DIS3L DDX27 ESF1 RPS28 WDR18 TFB2M RRP1 RPL35 NOLC1 DDX49 NSUN3 THUMPD1 DROSHA TSR1 RPS14 RRP7A LAS1L IMP3 TRMT112 EBNA1BP2 NOP56 DDX56 UTP18 PELP1 RPS15 RPL11 GTPBP4 ZNHIT6 URB1 NAT10 NVL RRP1B POP7 RRP8 MRPS11 UTP20 WDR3 RPS8 METTL15 EXOSC5 EXOSC2 HEATR1 NOL10 DDX54 RRP15 RRS1 LYAR MPHOSPH10 RBFA NAF1 IMP4 PELO RPS27 SLFN13 RPS9 RPL35A DDX10 RPP38 NSUN5 UTP6 PIH1D1 RPS7 up
## GO_PRERIBOSOME 0.0012903 0.0162793 0.5988320 2.342154 0 71 NOC2L TBL3 NOB1 MRTO4 NIP7 BMS1 UTP14A PWP2 EIF6 NOC4L PES1 FAM207A NOP14 NGDN RSL1D1 KRI1 RRP9 NOL6 BOP1 RRP1 TSR1 FBXW9 RRP7A LAS1L IMP3 EBNA1BP2 NOP56 UTP18 RRP1B UTP20 WDR3 HEATR1 NOL10 RRP15 RRS1 MPHOSPH10 IMP4 PPAN UTP6 RPS7 SRFBP1 up
## GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 0.0010537 0.0162793 0.4968259 2.338215 0 382 NOC2L MRPL20 EIF3B TBL3 NOB1 GNL2 PRPF6 MRTO4 USP39 NOM1 EXOSC10 NIP7 BMS1 CD2BP2 RPUSD1 ERI1 UTP14A ERI3 PWP2 EIF3I EIF6 EXOSC6 SBDS NOP2 NOC4L PES1 MYBBP1A FAM207A MDN1 RRN3 TSR3 METTL16 NSUN4 RPLP0 RPS21 LUC7L SF3A2 ISG20L2 RPP25 NOL9 MTG2 GEMIN4 NOP14 RPUSD2 PRMT7 RPLP0P6 RPS5 RPL24 MRPS2 RRNAD1 CLNS1A SNRNP200 XAB2 WDR55 NGDN XRN2 RSL1D1 NLE1 DDX51 KRI1 CPSF7 DDX31 SNRPD3 PRPF18 SRSF1 VCX RRP9 GEMIN8 RPL10A PRPF8 SF1 EIF3L NOL6 CELF5 SNRPB DHX37 CELF1 SART1 PRPF39 RPS2 SF3A3 BOP1 RPSA RUVBL2 WDR77 EIF3D DDX27 ESF1 SRPK1 RPS28 WDR18 RPL13A EIF3C TFB2M RRP1 RPL35 PRMT5 NOLC1 DDX49 NSUN3 RUVBL1 THUMPD1 SFSWAP ERAL1 AGO3 DROSHA TSR1 RPS14 RRP7A LAS1L IMP3 EIF3CL TRMT112 RPL3 EBNA1BP2 NOP56 DDX56 RPL12 UTP18 PELP1 NUP88 RPS15 RPL11 DDX23 GTPBP4 ZNHIT6 AATF URB1 MRPL11 NAT10 PRPF19 NVL DHX9 TXNL4A RRP1B POP7 EIF3G RRP8 ADAR MRPS11 MALSU1 UTP20 WDR3 AGO1 RPS8 METTL15 AGO4 EXOSC5 EXOSC2 HEATR1 NOL10 SART3 AAR2 LSM4 SRPK2 CELF4 URB2 SF3A1 DDX54 RRP15 DDX28 RRS1 LYAR GTPBP10 MPHOSPH10 RBFA NAF1 IMP4 RPL38 RPS27 HSP90AB1 RPS9 SNRPD2 AGO2 RPL35A CUL4B PPAN HEATR3 DDX10 EIF3M TSC1 MRPS7 RPP38 NSUN5 MPV17L2 UTP6 PIH1D1 RPS7 PAK1IP1 CDC73 SRFBP1 up
## GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 0.0011962 0.0162793 0.5416388 2.336248 0 152 MRPL20 MRPS34 MRPS18A RPL13 MRPS6 RPLP0 RPS21 MRPL55 MRPL49 MRPS15 RPLP0P6 RPS5 RPL24 MRPS2 MRPL14 RPLP1 RPL10A RPL22 MRPL28 RPL39 RPS3 RPL29 RPL18A MRPL17 RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 DAP3 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 MRPS35 RPLP2 MRPL37 RPS15 RPL11 MRPL54 MRPL11 RPL34 RPS15A MRPS11 MRPL41 RPL9 RPS23 RPS8 MRPS33 RPS29 MRPL24 RPL31 RPS27A UBA52 MRPL52 MRPL51 MRPL23 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 MRPS7 MRPL4 RPS4X MRPS30 MRPL12 RPS3A RPS7 RPL36AL MRPL32 MRPS23 RPL5 RPL27 RPL23A MRPL10 RPL23 RPL30 RPL14 RPS16 RPL41 MRPL34 MRPL21 up
## GO_NCRNA_METABOLIC_PROCESS 0.0010493 0.0162793 0.4906338 2.316625 0 396 MAEL TYW1 TDRD1 SMAD3 PUSL1 CTU2 TBL3 POLR3K NOB1 MTFMT MRTO4 EXOSC10 BMS1 FARSB INTS5 RPUSD1 ERI1 UTP14A ERI3 PUS7 TRIT1 GPAT2 PWP2 METTL3 EXOSC6 SBDS NARS2 NOP2 NOC4L INTS1 TRPT1 TRMT61A TSEN54 PES1 FAM207A MDN1 TSR3 GTPBP3 METTL16 NSUN4 RPS21 DIS3L2 TRMU AIMP2 EARS2 XPO5 ISG20L2 RPP25 NOL9 CTU1 GEMIN4 NOP14 INTS4 SEPHS2 RPUSD2 SRRT ADAT1 NSUN2 PNPT1 RRNAD1 WDR55 NGDN XRN2 RSL1D1 TP53RK DDX51 TRMT1 KRI1 DUS3L TRMT11 HRAS RELA DUS1L RRP9 TRMT5 RPL10A TARBP1 NOL6 TRMT12 DHX37 ZC3H12A SART1 RPS2 BOP1 DIS3L DDX27 ESF1 RPS28 WDR18 TFB2M RRP1 FARSA RC3H1 RPL35 NOLC1 DDX49 NSUN3 THUMPD1 AGO3 DROSHA TSR1 RPS14 RRP7A MEPCE TRMT6 LAS1L IMP3 TRMT112 EBNA1BP2 DGCR8 NOP56 DDX56 AARS2 UTP18 PELP1 RTCB TRMT44 RPS15 RPL11 PARN ANKRD16 CSTF2 ZBTB8OS ADAT3 GTPBP4 ZNHIT6 URB1 LCMT2 NAT10 PUS1 NVL USB1 PIWIL4 DDX4 RRP1B POP7 RRP8 ADAR MRPS11 KHSRP UTP20 WDR3 AGO1 RPS8 METTL15 AGO4 METTL1 TRDMT1 EXOSC5 EXOSC2 HEATR1 NOL10 TSEN2 RNF113A RPUSD4 MARS2 DDX54 PPA1 RRP15 RRS1 KTI12 LYAR HARS2 GATC MPHOSPH10 RBFA MOCS3 NAF1 FARS2 IMP4 PELO CDK5RAP1 RPS27 SLFN13 SARS2 RPS9 AGO2 SEPHS1 RPL35A DDX10 AIMP1 GRSF1 RPP38 CPSF4 DUS2 PUS10 NSUN5 UTP6 INTS7 DTD1 PIH1D1 RPS7 up
## GO_RIBOSOMAL_SUBUNIT 0.0011547 0.0162793 0.5263086 2.314515 0 172 MRPL20 MRPS34 MRPS18A RPL13 MRPS6 NSUN4 RPLP0 RPS21 MRPL55 MRPL49 MRPS15 RPLP0P6 MRPL48 RPS5 RPL24 MRPS2 MRPL14 NDUFAB1 RPLP1 RPL10A RPL22 MRPL28 RPL39 RPS3 RPL29 RPL18A MRPL17 RPS2 MRPS26 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 DAP3 NSUN3 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 MRPS35 RPLP2 MRPL37 RPS15 RPL11 MRPL54 MRPL11 RPL34 RPS15A MRPS11 MRPL41 MALSU1 RPL9 RPS23 RPS8 MRPS33 RPS29 MRPL24 RPL31 RPS27A UBA52 MRPL52 MRPL51 MRPL23 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 MRPS7 MRPL4 RPS4X MRPS30 MRPL12 C12orf65 MPV17L2 RPS3A RPS7 RPL36AL MRPL32 RPL5 RPL27 MRPS27 RPL23A MRPL10 RPL23 RPL30 EIF2D FXR2 RPL14 RPS16 RPL41 MRPL34 MRPL21 up
## GO_RIBOSOME_ASSEMBLY 0.0013717 0.0162793 0.6216240 2.311768 0 52 MRPL20 MRTO4 NIP7 PWP2 EIF6 SBDS NOP2 MDN1 NSUN4 RPLP0 RPLP0P6 RPS5 RPL24 MRPS2 NLE1 VCX BOP1 RPSA RPS28 ERAL1 RPS14 RRP7A RPL3 RPL12 RPS15 RPL11 MRPL11 MRPS11 DDX28 RRS1 RPL38 RPS27 PPAN MRPS7 MPV17L2 RPL5 RPL23A BRIX1 up
## GO_RIBOSOME 0.0011494 0.0162793 0.5123952 2.298051 0 211 MRPL20 AURKAIP1 MRPS34 MRPS18A RPL13 MRPS6 NSUN4 RPLP0 RPS21 MRPL55 RRBP1 MTG2 MRPL49 MRPS15 RPLP0P6 MRPL48 RPS5 RPL24 PNPT1 MRPS2 MRPL14 NDUFAB1 RPLP1 RPL10A SF1 RPL22 MRPL28 RPL39 RPS3 RPL29 RPL18A MRPL17 RPS2 MRPS26 RPL18 RPSA LARP4B RPL36 RPS12 RPS28 RPL13A RPL35 DAP3 HSPA14 NSUN3 RPS14 RPS13 RPS11 BTF3 RPL32 RPL3 MT3 RPL12 MRPS35 RPLP2 MRPL37 RPS15 RPL11 EIF2AK2 MRPL54 DNAJC21 MRPL11 DHX9 GADD45GIP1 RPL34 RPS15A MRPS11 MRPL41 MALSU1 RPL9 RPS23 RPS8 MRPS33 RPS29 MRPL24 LARP1 PTCD3 RPL31 RPS27A UBA52 MRPL52 MRPL51 MRPL23 RPS20 RPL38 APOD RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A EEF2 RPS26 MRPS7 MRPL4 RPS6KL1 RPS4X MRPS30 MRPL12 C12orf65 MPV17L2 RPS3A RPS7 RPL36AL MRPL32 MRPS23 RPL5 RPL27 EIF2AK4 MRPS27 RPL23A METTL17 MRPL10 SERP1 RPL23 RPL30 EIF2D FXR2 RPL14 CHCHD1 RPS16 RPL41 MRPL34 MRPL21 up
## GO_LARGE_RIBOSOMAL_SUBUNIT 0.0012151 0.0162793 0.5540558 2.293356 0 108 MRPL20 MRPS18A RPL13 NSUN4 RPLP0 MRPL55 MRPL49 RPLP0P6 MRPL48 RPL24 MRPL14 NDUFAB1 RPLP1 RPL10A RPL22 MRPL28 RPL39 RPL29 RPL18A MRPL17 RPL18 RPL36 RPL13A RPL35 NSUN3 RPL32 RPL3 RPL12 RPLP2 MRPL37 RPL11 MRPL54 MRPL11 RPL34 MRPL41 MALSU1 RPL9 MRPL24 RPL31 UBA52 MRPL52 MRPL51 MRPL23 RPL38 RPL4 RPL27A RPL37A RPL28 RPL19 RPL35A MRPL4 MRPS30 MRPL12 C12orf65 MPV17L2 RPL36AL MRPL32 RPL5 RPL27 RPL23A MRPL10 RPL23 RPL30 FXR2 RPL14 RPL41 MRPL34 MRPL21 RPL37 MRPL46 RPL8 MRPL27 MRPL33 RPL15 up
## GO_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0012346 0.0162793 0.5638636 2.292086 0 94 RPL13 RPLP0 RPS21 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 ZFAND2B RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 SSR2 RPS9 RPL19 RPL35A RPS26 RPS4X RPS3A RPS7 SRP54 RPL5 RPL27 RPL23A RPL23 RPL30 SRP14 RPL14 RPS16 RPL41 RPL37 SEC61A1 RPL8 SEC61A2 TRAM1 RPL15 SRP68 up
## GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS 0.0011587 0.0162793 0.5135421 2.276194 0 189 THRAP3 GSPT1 EDC4 RNPS1 HELZ2 MRTO4 EDC3 EXOSC10 EXOSC6 TNRC6A RPL13 SMG1 RPLP0 RPS21 DIS3L2 GTPBP2 RPS5 RPL24 LSM5 RPLP1 PRPF18 SMG5 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A ZC3H12A RPS2 RPL18 RPSA RPL36 RPS12 CPEB3 RPS28 RPL13A UPF3B TNKS1BP1 RC3H1 RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 SMG7 PARN ETF1 PAN2 SAMD4A RPL34 RPS15A RPL9 RPS23 AGO1 RPS8 DCPS EXOSC5 EXOSC2 RPS29 LSM4 MAGOH EIF4G1 CTIF RPL31 RPS27A UBA52 RPS20 PELO RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 AGO2 RPL19 RPL35A CNOT4 RPS26 UPF1 RPS4X SMG6 RPS3A RPS7 SAMD4B RPL5 DHX34 CNOT11 RPL27 RPL23A RPL23 RPL30 PPP2R1A ZFP36L1 RPL14 RPS16 RPL41 up
## GO_CYTOSOLIC_RIBOSOME 0.0012330 0.0162793 0.5505087 2.242469 0 95 RPL13 RPLP0 RPS21 RPLP0P6 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPS20 RPL38 APOD RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPS4X RPS3A RPS7 RPL36AL RPL5 RPL27 EIF2AK4 RPL23A RPL23 RPL30 EIF2D FXR2 RPL14 RPS16 RPL41 up
## GO_VIRAL_GENE_EXPRESSION 0.0011534 0.0162793 0.5049427 2.234575 0 185 EIF3B RSF1 SMARCA4 HDAC1 TARDBP EP300 RPL13 PTBP1 RPLP0 RPS21 NUP160 INPP5K RPS5 RPL24 MID2 TRIM62 NELFCD RPLP1 NELFA RPL10A RPL22 EIF3L RPL39 RPS3 PSMC3 RPL29 RPL18A RPS2 RPL18 RPSA EIF3D RPL36 POLR2L RPS12 RPS28 RPL13A NUP93 NUP205 RPL35 CTDP1 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 GTF2F1 POLR2C RPLP2 POLR2J NUP88 RPS15 RPL11 TRIM11 NUP98 DHX9 TRIM21 RRP1B RPL34 EIF3G RPS15A POLR2E RPL9 RPS23 NUP50 RPS8 POU2F3 NUP133 RPS29 NELFB NUP214 SMARCB1 RPL31 TPR RPS27A UBA52 POLR2F RPS20 MON1B RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 NUP153 RANBP2 TFAP4 RPS4X NDC1 RPS3A RPS7 SUPT5H RPL5 SP1 RPL27 EIF2AK4 RPL23A RPL23 RPL30 EIF2D NUP188 USF1 RPL14 NUP85 RPS16 RPL41 up
## GO_PROTEIN_TARGETING_TO_MEMBRANE 0.0011587 0.0162793 0.5072920 2.230181 0 173 ZDHHC4 ANK3 MYO1C ZDHHC11 ZDHHC11B TAOK2 ICMT CIB1 ZDHHC7 RPL13 RPLP0 RPS21 HPCA CDK5 VPS37B INPP5K RPS5 RPL24 PEX16 PAK1 RPLP1 HRAS ZDHHC9 RPL10A RPL22 DMTN RPL39 RPS3 RPL29 RPL18A MICALL1 ZDHHC1 RPS2 GDI1 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RTP4 RPL35 RPS14 RPS13 RPS11 VPS37C RPL32 RPL3 ZDHHC3 RPL12 RPLP2 CHMP4B RPS15 RPL11 ARL6 ERBB2 FIS1 RPL34 RPS15A SGTA RPL9 ZDHHC15 ZDHHC12 RPS23 ZDHHC23 RPS8 RABGEF1 MIEF2 RPS29 EXOC4 ZFAND2B RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 SSR2 RPS9 RPL19 RPL35A C2CD5 RPS26 RPS4X RPS3A PARD3 RPS7 SRP54 SLC51B RPL5 AKT2 RPL27 RPL23A RPL23 RPL30 ITGB1BP1 PEX3 SRP14 RPL14 RPS16 RPL41 up
## GO_RRNA_BINDING 0.0013736 0.0162793 0.5953384 2.219186 0 55 MRPL20 ERI1 MRPS18A FASTKD5 SBDS MRPS6 NSUN4 RPLP0 RPLP0P6 RPS5 ANG RPS3 ERAL1 RPS14 RPS13 RPS11 NGRN IMP3 RPL3 RPL12 RPL11 MRPL11 MRPS11 RPL9 DDX28 RRS1 PTCD3 RPS9 EEF2 MRPS7 RPS4X TST RPL5 MRPS27 RPL23A RPL23 up
## GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE 0.0010799 0.0162793 0.4756531 2.217237 0 296 GET4 ZDHHC4 ANK3 MYO1C BAD ZDHHC11 C16orf70 ZDHHC11B TAOK2 BRAF ICMT CIB1 ZDHHC7 RILPL1 CLSTN1 RPL13 CLIP1 RPLP0 RPS21 HPCA GOLPH3 CDK5 STX3 VPS37B TFDP1 INPP5K RPS5 RPL24 PEX16 ARFRP1 TIMM22 BLZF1 PAK1 RPLP1 HRAS ZDHHC9 RPL10A RPL22 SPTBN1 DMTN RPL39 RPS3 AGK RPL29 EGFR RPL18A MICALL1 ZDHHC1 RPS2 CPLX1 CNST GDI1 TIMM9 RPL18 RPSA TP73 RPL36 RPS12 LRRC1 MACF1 GGA3 RPS28 RPL13A RTP4 RPL35 ARHGAP44 TOMM22 RAB11B RPS14 GRIN3B RPS13 RPS11 VPS37C VAMP3 RPL32 RPL3 ZDHHC3 RPL12 GRIPAP1 RPLP2 CHMP4B RAB11A RPS15 RPL11 GOLGA4 NMT1 ARL6 ERBB2 FIS1 RPL34 RPS15A SGTA RPL9 ZDHHC15 ZDHHC12 RPS23 ZDHHC23 PPP1R13B RPS8 YWHAG RAB3GAP2 RABGEF1 GGA1 REEP1 MIEF2 PKDCC RPS29 EXOC4 BBS2 PMAIP1 ZFAND2B GORASP1 RPL31 E2F1 RPS27A UBA52 NDUFA13 RPS20 KIF13A RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 SSR2 SEC16A RPS9 RPL19 BAX KRT18 RPL35A RAB34 TIMM13 PREPL C2CD5 RPS26 TIMM10 ROMO1 RPS4X RPS3A PARD3 RPS7 YWHAE SYS1 OPTN TP53 SRP54 SLC51B RPL5 CD24 AKT2 RPL27 GORASP2 RPL23A OXA1L RPL23 RPL30 GGA2 ITGB1BP1 PEX3 SRP14 SNAP47 RPL14 up
## GO_MITOCHONDRIAL_PROTEIN_COMPLEX 0.0011416 0.0162793 0.4918525 2.217227 0 217 DNAJC11 MRPL20 MCU MRPS34 MICU1 SDHB MRPS18A UQCRC2 CLPX MRPS6 NSUN4 FOXRED1 MRPL55 NDUFB10 MRPL49 NDUFS4 MRPS15 MRPL48 CHCHD3 PNPT1 MRPS2 MRPL14 MCCC1 NDUFAB1 BCKDK TIMM22 MT-CYB MT-CO1 MT-ND3 SDHA SPG7 GRPEL1 MRPL28 IMMT AGK MRPL17 MRPS26 TIMM9 NDUFB2 MT-ND4L NDUFA4 POLRMT MTX1 DAP3 NSUN3 NDUFS3 UQCR10 TOMM22 MT-ND5 MRPS35 POLG MRPL37 NDUFS6 MRPL54 NDUFB7 MRPL11 WDR93 MT-ATP6 TIMM8B MRPS11 MRPL41 MT-ND4 MALSU1 NDUFV1 NDUFC2 TOMM40 MRPS33 BCKDHB CHCHD10 TOMM20 MRPL24 TOMM7 VDAC1 NDUFA9 UQCRH NDUFA13 MRPL52 MRPL51 MRPL23 NDUFS5 ANKZF1 MT-ND2 COX6A2 TOMM20L BAX TIMM13 IMMP2L MRPS7 MRPL4 PMPCA TIMM10 ROMO1 COA3 NDUFA10 MRPS30 MRPL12 MCCC2 C12orf65 COX4I1 MPV17L2 UQCRQ NDUFS8 NDUFC1 MRPL32 PMPCB CYC1 NDUFA2 NDUFB9 MRPS27 SUPV3L1 MRPL10 APOO CHCHD6 NDUFS7 MRPL34 TIMM50 MRPL21 NDUFA4L2 APOOL MT-ND1 MRPS28 MT-ATP8 NDUFAF1 MRPL46 MTX2 MRPL27 NDUFB1 MRPL33 TRMT10C AFG3L2 up
## GO_REGULATION_OF_AUTOPHAGY_OF_MITOCHONDRION 0.0014205 0.0162793 0.6424747 2.212312 0 37 VPS13D ATP13A2 MFN2 SMURF1 CLEC16A CTTN CDC37 TSC2 VPS13C SREBF2 PARK7 MUL1 PINK1 TSPO RNF41 TOMM7 VDAC1 GBA HK2 HTT HAX1 OPTN TP53 FZD5 up
## GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 0.0012034 0.0162793 0.5241838 2.210901 0 128 ANKRD13C RER1 PMM2 DDRGK1 RPL13 RPLP0 RPS21 PDIA2 GRIK5 KDELR2 RPS5 RPL24 LRRK2 TAPT1 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 CHMP4B RPS15 RPL11 RPL34 RPS15A SGTA RPL9 OS9 RPS23 RPS8 RAB3GAP2 RPS29 ZFAND2B RPL31 RPS27A UBA52 SEC61G RPS20 RPL38 SEC16B RPL4 RPS27 RPL27A RPL37A RPL28 SEC16A RPS9 RPL19 RPL35A RPS26 RPS4X BCAP29 RPS3A RPS7 KDELR3 SRP54 RPL5 RPL27 RPL23A RPL23 RPL30 SRP14 RPL14 RPS16 RPL41 MIA3 RPL37 SEC61A1 RPL8 SEC61A2 TRAM1 RPL15 GBF1 SRP68 up
## GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION 0.0011521 0.0162793 0.4990840 2.199419 0 177 MRPL20 EIF3B PRPF6 MRTO4 USP39 CD2BP2 PWP2 EIF3I EIF6 NOP2 MDN1 RPLP0 LUC7L SF3A2 GEMIN4 PRMT7 RPLP0P6 RPS5 RPL24 CLNS1A SNRNP200 XAB2 NLE1 CPSF7 SNRPD3 PRPF18 SRSF1 GEMIN8 PRPF8 SF1 EIF3L CELF5 SNRPB CELF1 SART1 PRPF39 SF3A3 BOP1 RPSA RUVBL2 WDR77 EIF3D TFIP11 SRPK1 RPS28 RPL13A EIF3C PRMT5 RUVBL1 SFSWAP ERAL1 AGO3 RPS14 RRP7A EIF3CL RPL3 RPL12 RPS15 RPL11 DDX23 ZNHIT6 MRPL11 PRPF19 DHX9 TXNL4A EIF3G ADAR MRPS11 AGO1 AGO4 SART3 AAR2 LSM4 SRPK2 CELF4 SF3A1 DDX28 RRS1 NAF1 RPL38 RPS27 HSP90AB1 SNRPD2 AGO2 PPAN EIF3M MRPS7 PIH1D1 CDC73 ZFAND1 RPL5 SNUPN GEMIN6 SRSF9 RPL23A ATR EIF3J BRIX1 EIF2D RBMX RPF2 SRSF10 SMN2 SNRPC GEMIN5 NUDT21 NOL3 SNRPE SRSF6 DDX20 DHX30 up
## GO_RIBONUCLEOPROTEIN_COMPLEX 0.0010215 0.0162793 0.4536307 2.196591 0 630 NOC2L MRPL20 SRRM1 EIF3B SNORA74A SNRNP25 TBL3 GTF3C1 NOB1 MKRN3 SRRM2 PRPF6 MRPS34 MRTO4 USP39 ZNF830 NIP7 BMS1 CD2BP2 ERI1 UTP14A IGHMBP2 CWC25 PWP2 SF3B3 MRPS18A EIF3I EIF6 TARDBP TNRC6A NOC4L RBMX2 PES1 FAM207A RPL13 MRPS6 NSUN4 TERC RPLP0 RPS21 DIS3L2 LUC7L MRPL55 DHX29 XPO5 SF3A2 RPP25 RNPC3 MRPL49 GEMIN4 NOP14 MRPS15 RPLP0P6 MRPL48 RPS5 RMRP RPL24 PNPT1 MRPS2 LRRK2 MRPL14 SNRNP200 XAB2 NDUFAB1 LSM5 DDX41 NGDN RSL1D1 CSNK1A1 KRI1 RPLP1 PPP1R8 DHX38 SNRPD3 PRPF18 SRSF1 AKAP8L RRP9 SMG5 RPL10A PRPF8 SF1 RPL22 EIF3L MRPL28 SNIP1 CACTIN DDX53 NOL6 CELF5 RPL39 RPS3 SNRPB RPL29 RPL18A ATXN2 CELF1 SART1 MRPL17 PRPF39 RPS2 ACTN4 MSI1 SF3A3 MRPS26 PRPF38A BOP1 RPL18 RPSA LARP4B RUVBL2 EIF3D PPIE SREK1 CDC5L RPL36 MYH10 RPS12 TFIP11 PKP3 CPEB3 RPS28 RPL13A EIF3C PHF5A RRP1 RPL35 NOLC1 ILF3 DAP3 HSPA14 NSUN3 RUVBL1 AGO3 LRPPRC TSR1 FBXW9 RPS14 RPS13 RRP7A RPS11 LAS1L IMP3 EIF3CL BTF3 RPL32 RPL3 PSMA6 EBNA1BP2 NOP56 RPL12 MRPS35 UTP18 SNRNP40 ELAVL1 RPLP2 MRPL37 AQR MSI2 RPS15 RPL11 DDX23 SMG7 HTATSF1 MRPL54 ZNHIT6 HNRNPAB PABPC1L LGALS3 U2AF2 SF3B2 NUP98 NCL MRPL11 NAT10 PRPF19 NVL DHX9 FUS TXNL4A MCRS1 TRIM21 RRP1B MYEF2 POP7 RPL34 EIF3G RPS15A ADAR MRPS11 RBM17 MRPL41 MALSU1 DHX15 RPL9 LARP6 UTP20 DRG1 RPS23 WDR3 AGO1 RPS8 AGO4 MRPS33 IGF2BP1 HEATR1 NOL10 WDR83 RPS29 SART3 MRPL24 AAR2 SLBP LSM4 MAGOH CELF4 RNF113A EIF4G1 SF3A1 MFAP1 SNRNP35 ALYREF RRP15 RRS1 LARP1 BUD13 RPL31 RALY ZC3H14 RPS27A UBA52 MRPL52 MPHOSPH10 MRPL51 MRPL23 NAF1 IMP4 RPS20 DAZAP1 PABPC4 RPL38 ZMAT5 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 SNRPD2 AGO2 RPL19 RPL35A PPAN EEF2 EIF3M RPS26 RBM22 SNRPN MRPS7 MRPL4 RPP38 HNRNPR UPF1 RPS4X MRPS30 SMG6 MRPL12 C12orf65 SNRPB2 MPV17L2 TERT RBM28 RPS3A UTP6 SNORA63 PIH1D1 RPS7 RPL36AL SRFBP1 MRPL32 RBMS2 SRP54 DYRK1A PDCD7 RPL5 LSM10 NAA30 RPL27 EIF2AK4 MRPS27 RPL23A SNORA62 PPIH MRPL10 BUD31 RPL23 EEFSEC RPL30 SNRPA EIF3J DHX35 ELAVL2 RBM14 EIF2D NSRP1 SNRNP70 FXR2 ARFGEF1 ZFP36L1 SRP14 RIOK2 up
## GO_RNA_PROCESSING 0.0010091 0.0162793 0.4487882 2.192181 0 817 TYW1 SSU72 CDK13 SRSF4 THRAP3 AURKAIP1 RNF40 SRRM1 SMAD3 PUSL1 SLTM CDK11B MNAT1 SNRNP25 CTU2 TBL3 POLR3K NOB1 RNPS1 TBRG4 SRRM2 MTFMT PRPF6 RP9 MRTO4 USP39 ZC3H7A ZNF830 EXOSC10 CDK11A BMS1 INTS5 CD2BP2 RPUSD1 ERI1 CLK3 UTP14A APOBEC1 ERI3 PUS7 CWC25 TRIT1 PWP2 SF3B3 METTL3 PUM1 EXOSC6 TARDBP FASTKD5 SBDS FASTK CHERP NOP2 NOC4L INTS1 RBMX2 TRPT1 TRMT61A TSEN54 PES1 ZC3H7B FAM207A MDN1 TSR3 GTPBP3 METTL16 NSUN4 PTBP1 RPS21 LUC7L TRMU ZMPSTE24 SF3A2 ISG20L2 RPP25 NOL9 CTU1 LEO1 RNPC3 GEMIN4 NOP14 AHCYL1 CMTR1 INTS4 SEPHS2 RPUSD2 SRRT PRMT7 ADAT1 RMRP NSUN2 PNPT1 THOC6 A1CF RRNAD1 CLNS1A SNRNP200 XAB2 HABP4 APP CCAR2 RBPMS LSM5 WDR55 DDX41 NGDN XRN2 RSL1D1 TP53RK DDX51 TRMT1 KRI1 CPSF7 DUS3L PPP1R8 DHX38 TRMT11 ESRP2 SNRPD3 PRPF18 SRSF1 KDM1A DUS1L ZBTB7A AKAP8L RRP9 PHRF1 GEMIN8 TRMT5 RPL10A PRPF8 SF1 SCAF1 ZNF473 TARBP1 SNIP1 CACTIN NOL6 TRMT12 PCF11 CELF5 RBM15 SNRPB DHX37 EGFR CELF1 POLDIP3 ZC3H12A SART1 PRPF39 MAP2K1 RPS2 SF3A3 PRPF38A BOP1 MAP2K2 WDR77 PPIE SREK1 ACIN1 CDC5L DDX27 ESF1 POLR2L TFIP11 CPEB3 SRPK1 RPS28 WDR18 UPF3B MBNL2 HNRNPLL RPRD1B PHF5A PRCC TFB2M RRP1 RPL35 SUPT6H TSN PRMT5 NOLC1 DDX49 DDX46 NSUN3 THUMPD1 SFSWAP AGO3 KHDRBS1 DROSHA TSR1 IWS1 RPS14 RPS13 RRP7A TRMT6 LAS1L IMP3 TRMT112 EBNA1BP2 NCOR2 DGCR8 NOP56 DDX56 AARS2 UTP18 SNRNP40 NONO ELAVL1 GTF2F1 POLR2C PELP1 POLR2J AQR ADARB2 RTCB TRMT44 RPS15 RPL11 DDX23 PARN ANKRD16 HTATSF1 CSTF2 ZBTB8OS ADAT3 GTPBP4 ZNHIT6 PAN2 PABPC1L URB1 LGALS3 U2AF2 SF3B2 LCMT2 NUP98 NCL NAT10 PUS1 CLASRP PRPF19 NVL DHX9 FUS USB1 TXNL4A APOBEC4 RRP1B POP7 ADARB1 RRP8 POLR2E ADAR MRPS11 CDK12 RBM17 GTF2H3 RNASEL DHX15 LARP6 ESRP1 CMTR2 DNAJC8 SUGP2 KHSRP UTP20 SRSF7 MYCN WDR3 ZNF638 AGO1 SON RPS8 METTL15 AGO4 DCPS METTL1 TRDMT1 EXOSC5 EXOSC2 HEATR1 NOL10 WDR83 SART3 AAR2 SLBP LSM4 TSEN2 MAGOH SRPK2 CELF4 DDX39A HNRNPUL1 RNF113A RPUSD4 SF3A1 MFAP1 DDX54 SNRNP35 ALYREF RRP15 APOBEC2 RRS1 KTI12 BUD13 RALY LYAR ZC3H14 RPRD2 POLR2F MPHOSPH10 RBFA MOCS3 NAF1 FARS2 IMP4 DAZAP1 PABPC4 ZMAT5 CDK5RAP1 RPS27 SFPQ RPS9 SNRPD2 SAFB2 AGO2 SEPHS1 RPL35A THOC2 DDX10 ALKBH5 RPS26 RBM22 GRSF1 SNRPN WDR33 RPP38 CPSF4 TRMT2A HNRNPR DUS2 PUS10 NSUN5 SNRPB2 TERT ZC3H3 RBM28 UTP6 INTS7 PIH1D1 RPS7 CDC73 SRFBP1 TP53 RBMS2 SUPT5H BMP4 RBM11 DYRK1A PDCD7 RPL5 SNUPN LSM10 DDX42 GEMIN6 PPP3CA RBFOX2 RPL27 RBBP6 SRSF9 SRSF11 SUPV3L1 PIWIL2 PPIH PPIG BUD31 WDR4 ZRANB2 SNRPA DHX35 ELAVL2 PPP2R1A NSRP1 SNRNP70 PAF1 FXR2 ZFP36L1 INTS10 CCAR1 RIOK2 RBMX RPL14 PUS3 QTRT1 NOP10 DUS4L RPS16 GTF2H5 CSTF1 METTL2B RPF2 SRSF10 SMN2 HNRNPF SNRPC GEMIN5 RBFOX1 PPP1R9B FTSJ3 TRMT1L TUT1 RBM19 EFTUD2 ERN1 ZCCHC8 WDR43 NUDT21 ERCC2 PAPOLB NOL3 ELAC2 SNRPE up
## GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 0.0012151 0.0162793 0.5265451 2.174017 0 106 PMM2 RPL13 RPLP0 RPS21 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 CHMP4B RPS15 RPL11 RPL34 RPS15A SGTA RPL9 RPS23 RPS8 RAB3GAP2 RPS29 ZFAND2B RPL31 RPS27A UBA52 SEC61G RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPS4X RPS3A RPS7 SRP54 RPL5 RPL27 RPL23A RPL23 RPL30 SRP14 RPL14 RPS16 RPL41 RPL37 SEC61A1 RPL8 SEC61A2 TRAM1 RPL15 SRP68 up
## GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS 0.0013316 0.0162793 0.5694166 2.166409 0 61 TBL3 NOB1 NOM1 BMS1 PWP2 FAM207A TSR3 RPS21 NOP14 RPS5 NGDN KRI1 DHX37 RPSA RPS28 ERAL1 TSR1 RPS14 RRP7A RPS15 NAT10 MRPS11 UTP20 RPS8 HEATR1 NOL10 RRS1 RPL38 RPS27 MRPS7 UTP6 RPS7 SRFBP1 up
## GO_CADHERIN_BINDING 0.0010799 0.0162793 0.4647848 2.163210 0 299 PDXDC1 ARHGEF16 BAIAP2L1 PTPRH GIPC1 ANK3 EPS8L1 LYPLA2 EHD4 PLCB3 TJP2 PACSIN2 OLFM4 LIMA1 UBAP2 CDH9 PPL CTTN MARK2 PKP4 MPRIP PPME1 GLOD4 SRC ESYT2 PKM VAPB CDH1 EPHA2 ARHGAP1 DHX29 GPRC5A ATXN2L ACVR1 SNX1 LAD1 ENO1 EZR ARFIP2 CGN CDC42EP1 DAB2IP EPS8L2 PARK7 RPL24 SLC9A3R2 SPTAN1 UNC45A EPS15L1 CDH7 NUDC PKN2 ABCF3 RSL1D1 USP8 CTNNA2 CDH4 EXOC3 ANXA2 EPN2 CAST SPTBN1 UBFD1 EPCAM MPP7 RPL29 EGFR MICALL1 RPS2 CTNND1 CC2D1A PKP3 MACF1 PAK4 RANBP1 TNKS1BP1 DBNL DOCK9 PAK6 CDH3 SCYL1 RUVBL1 KLC2 YKT6 RANGAP1 RAB11B TJP1 ERC1 ATIC BSG SNX5 NOP56 DLG1 SWAP70 CHMP4B GOLGA3 KTN1 MYH9 PPP1R13L LRRC59 PI4KA CHMP2B GIGYF2 FNBP1L RPL34 EVPL CDH12 TRIM25 SH3GL1 HDLBP SH3GLB2 STK24 LARP1 CSNK1D PKP2 TMOD3 HSP90AB1 SLC3A2 SERBP1 KRT18 VASN CCS EEF2 BZW2 EEF1D RPS26 CD46 FLNB MMP24 IST1 EFHD2 STK38 CHMP5 PTPRT GOLGA2 YWHAE ARGLU1 CD2AP JUP CKAP5 up
## GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 0.0013459 0.0162793 0.5671855 2.160091 0 62 NOC2L MRPL20 MRTO4 NIP7 EIF6 NOP2 PES1 MDN1 RPLP0 NOL9 RPLP0P6 RPL24 RSL1D1 NLE1 RPL10A BOP1 RPL35 LAS1L RPL3 EBNA1BP2 RPL12 RPL11 GTPBP4 ZNHIT6 URB1 MRPL11 NVL MALSU1 DDX28 RRS1 RPL38 RPL35A PPAN HEATR3 PAK1IP1 RPL5 RPL23A BRIX1 RPL14 RPF2 FTSJ3 up
## GO_CILIARY_BASAL_BODY 0.0012165 0.0162793 0.5202957 2.143563 0 102 NPHP4 DAAM1 C2CD3 WRAP73 ARMC9 KIF7 IFT140 AKT1 BBS5 AGBL4 PIFO IFT81 TTC26 EZR DLG5 TAPT1 IFT57 CSNK1A1 CBY1 TUBG1 CEP250 TRAF3IP1 RABEP2 ARHGAP35 CDK10 PKD2 KIAA0586 DZIP1L MKS1 GAS8 MARK4 ERC1 LCA5 FOPNL TBC1D30 CCDC151 FAM161A RAB28 EVC BBS2 PTPN23 AGBL2 CDKL5 SSNA1 BBS4 IFT122 TTC30B TTBK2 IFT52 OFD1 WDR34 PCM1 ICK IFT172 FBF1 RPGRIP1L TTC30A DYNC2LI1 NEK4 FANK1 B9D2 WDR35 SDCCAG8 TOPORS TTLL6 MLF1 TTC8 BBS7 ODF2L INTU IFT88 up
fgsea_plot(fgsea_res$res_c6, pathways_title='C6 oncogenic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ----------------------- ---------- ---------- ---------- --------- ------------- ----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## MYC_UP.V1_UP 0.0012005 0.0097297 0.4840158 2.100259 0 157 TRNAU1AP CDCA7L MRTO4 TMEM201 CCDC78 NIP7 FARSB UTP14A DGAT2 IPO4 PUS7 PMM2 MICU1 NOC4L PES1 SIX3 SLC25A22 DCTPP1 HS6ST2 NOP14 UBIAD1 REPIN1 FAM86C1 SPATC1L CALML4 RPTOR NLE1 TRMT1 RRP9 C19orf48 PRR7 PRMT3 NOL6 MNT MTFP1 GPD1L TMEM132B DIS3L ESF1 GP2 SLC29A4 AMPD2 CHKA TFB2M KLF16 LRRC61 CD320 QSOX2 LAS1L NR2C2AP JPH1 DPYSL5 B3GNTL1 PUS1 PPRC1 LYPD6 USE1 C20orf27 ECE2 TGFBRAP1 CCDC124 VPS9D1 METTL1 CHCHD10 EXOSC5 WDR83 RPUSD4 DPP7 PLA2G4A RRP15 MPHOSPH10 TMEFF2 ISOC2 SMYD5 DDX10 ICAM5 SLC27A2 ABCC6P2 UBE3D MON1A AGPAT3 C5orf46 RRP12 WDR4 KLRG2 TOP1MT PUS3 CAPS C12orf66 QTRT1 GLRX5 SCFD2 TDRD10 up
## P53_DN.V1_UP 0.0011806 0.0097297 0.4607884 2.029290 0 182 DHRS3 SUN1 SERPINB5 PTPRH DAAM1 LPCAT4 EXPH5 TJP2 TMEM30B TPBG PPL SYNJ2 LRIG1 TACSTD2 MARK2 SMAGP TSPAN8 RAMP1 CST6 SNHG3 AGR2 LSR FHL2 IFI27 SDC4 TOX3 ELF4 AUTS2 PRSS3 ME3 KLK10 CTNNBIP1 DMD LZTS3 ASS1 SOX9 PTN EPCAM CDKN2A EGFR AZGP1 GPSM2 HDAC9 SMAD6 ADORA2B AHR CHKA NKX2-1 KRT19 RNF11 PTK7 PPARD PLCE1 MEIS2 LRRC42 CORO2A MAP3K5 UGT8 MYOF BCAR3 NEBL MAFF TUBA4A YAP1 LOXL1 MISP UQCRH EFEMP1 ITGA2 ANXA2P1 up
## LEF1_UP.V1_DN 0.0012019 0.0097297 0.4523815 1.974701 0 173 TFF1 KIAA0319L USP18 TMPRSS3 SLC1A1 NME3 ANK3 CYP2J2 GDE1 SLC6A20 TMEM53 CFTR BDKRB2 HERC6 ANKFY1 TSPAN8 IL20RA OAS3 AGR2 ELF3 SH3GL2 TRPM4 RAB25 VILL PRSS8 FOXA1 TMED3 TRAF3IP2 MVP TLR3 PAK1 PLLP GDPD3 KCNV1 SLC22A18 MANSC1 EHF ACSF2 AP1M2 MOCOS CXCL5 ENTPD3 PLAC8 RBM47 DDX58 TSPAN1 CTSH PRR15L OAS1 TMEM144 LGR5 ALDH5A1 GATA6 DAPK1 ENC1 RAB27B ALCAM RABL6 HOXB13 GALNT12 PTPN13 SAMD9 ACSL5 PDZK1IP1 HCFC1R1 up
## LTE2_UP.V1_DN 0.0011806 0.0097297 0.4459841 1.964093 0 182 NAV2 ISG15 USP18 PPM1E SLC1A1 IFI6 OASL IFIT1 KAZN MYO10 ARHGAP12 GPER1 NIP7 UTP14A HERC6 OAS3 BST2 LGR4 DDX60 IFI35 RRN3 FHL2 IFI27 LGALS3BP ZNF273 ELF4 PTPRK NUP160 ASCL1 CRABP1 GTF2I SVIL IFI44L FTO PLCB1 GRB10 SLC16A7 SYTL2 PTGES IFIT3 IFI44 TAF12 IFRD1 MOCOS TFAP2A DDX58 OAS2 PARP12 OAS1 DLC1 TSPO NCOR2 ZNF107 RHOBTB3 RPS6KA3 EIF2AK2 CALCR IFITM1 IRF7 HES1 SAMD9 BTG3 POT1 IFIT5 PMAIP1 EFEMP1 GADD45A TDRD7 UBE2L6 PRKAR2B HERC5 MDK up
## MTOR_UP.V1_UP 0.0012107 0.0097297 0.4192933 1.812944 0 153 NTSR1 USP18 SERPINB5 IFIT1 GSS IDH3A CCDC86 TMEM53 FDFT1 SC5D RCOR2 CYP51A1 PREP AP2B1 SCGB3A2 BST2 TNFRSF12A IFI35 PAFAH2 MSX2 PLAT LDLR DHCR7 ADRA1B CCAR2 TIPIN KRBA1 CYP26A1 TRMT5 IFIT2 PTPN14 SLC2A1 ADORA2B PCYT2 DHCR24 OAS2 RGS11 BDH1 HIVEP3 GSDMC DLG4 ABCA2 LGALS3 CAPN12 TPH1 ALDOC PRKCA HMGCS1 ZNF518B PCNA SQLE H6PD HTT COQ4 ATXN7L1 PPAN COMTD1 CPPED1 FAM131A up
## CAMP_UP.V1_UP 0.0011848 0.0097297 0.4107973 1.805068 0 181 FBXO42 SESN2 WDR24 TRIM2 AKAP6 RBCK1 IPO4 BLCAP MRPS18A TRMT61A XIST GAS5 EARS2 RHOT2 PRMT1 AHCYL1 CRABP1 CMTR1 EIF2B3 NRSN2 SLC25A5 LONP1 IFIT2 PYCR2 RPL18A CEP250 MIDN IFRD1 KANSL3 GPR160 SRPK1 ARF1 FAHD2A MAEA DAP3 NSUN3 RUVBL1 RABGGTA HSPBP1 CKMT1A HSPA9 TMEM8B DDX23 AATF SAT2 IFITM1 TAF1D ECSIT RNF41 DIP2B NDUFV1 GMPPA ZDHHC23 ANKHD1-EIF4EBP3 CCDC124 LETMD1 PMAIP1 CHAF1A MAGOH ANKRA2 HDLBP ATP1A1 ZNF385A SELENBP1 SMYD5 HAX1 ETV5 COX8A IST1 P4HB PLCH1 TMEM116 TYMP ATF4 KAT5 TNIK CS METTL17 OXA1L KIAA0040 PDE4DIP DPM2 UPP1 SIL1 up
## AKT_UP.V1_UP 0.0012136 0.0097297 0.4176121 1.804927 0 152 GIPC1 IFIT1 GDE1 PACSIN3 FDFT1 CYP51A1 PREP TACSTD2 HOXB9 MICU1 MYO5B GUSB LRG1 TNFRSF12A CLMN PLAT VILL LDLR DHCR7 SECTM1 CD55 PAK1 TJP3 SH3BGRL2 IFIT2 PTPN14 IFIT3 RIPK3 SLC2A1 GAK SYT17 ADORA2B DHCR24 PDZD11 SGSM3 TPRN TOM1L1 TRAF4 KCNK5 MAL2 GSDMC ACOT9 PTRH1 DLG4 SNHG11 ALDOC UGT8 MMP15 DUSP10 ROPN1L ABCA7 C3orf52 BPGM GPD2 PON2 COMTD1 CAMKK1 FBXO6 HIC2 BACE2 CALCB SUCO CDKN2B PRKCH LSS PFKP TMPRSS4 FAM3B PARM1 FXR2 up
## PDGF_ERK_DN.V1_UP 0.0012626 0.0097297 0.4260407 1.799994 0 128 ANXA10 RALYL NTNG1 SOX21 AAGAB CCP110 EXOSC10 MPI MID1 PPP1R37 SERPINB2 CHEK2 TSPAN5 CFDP1 GALNT3 RRBP1 NUP160 CMTR1 CLEC2B ANXA11 CDC14B CALML4 PKN2 SNRPD3 LRCH4 CLCN2 ATXN2 ZIC4 MYBPC3 VPS39 PHLDA2 TAF12 STX12 C17orf75 OXCT1 LAS1L SNRNP40 SWAP70 ALDH5A1 PSMB10 MVK PAN2 NEK9 MRPS11 NDN SNX19 ATXN7 HDLBP COL1A1 LRPAP1 COL10A1 THOC2 LUZP2 TSPAN9 RPIA ABCC6P2 MTHFR TAF1B TAT TAB1 TBX5 KLK7 up
## TBK1.DF_DN 0.0011123 0.0097297 0.3920581 1.795136 0 265 DNAJC16 IFIT1 YTHDF2 EXPH5 CLEC16A MYO6 RSF1 RCC1 NIP7 ANKFY1 PKP4 KPNA6 PMEPA1 GNE RAI14 FLRT3 DDX60 TSPAN5 GALNT3 RRN3 SMG1 CDR2 TBC1D10B LETM1 CRK SNTB2 COASY GEMIN4 TTPAL SEPHS2 TERF2 HOOK1 ARFGEF2 POLR3B RLF SMC5 ODF2 GALNT11 SMAD5 ANKRD11 KIF3A PTGES EHF CDCA4 TTI1 CBX6 ZKSCAN1 KDM4A ESF1 AKAP9 MTR ETNK1 BDH1 SEMA3C CBFB CAMK2N1 KCTD3 BPTF GOLGA4 KTN1 BCL2L1 ZNHIT6 AFF4 CHMP2B RBBP5 SLC25A13 PDHX FNBP1L HMGCS1 MFSD6 TEAD1 RRN3P1 LRIG2 MRPS33 ANGPTL4 PRRC2B GAS1 ZWINT PPCS PMAIP1 ROCK2 ITGA2 SLC39A8 TCOF1 RALA OSBPL3 NDUFA13 BPHL TMOD3 PDGFA PCBD1 NF1 NEK7 THOC2 SLC22A5 KLF13 TTBK2 GALNT7 RMND1 COL5A2 GOLGA2 NCOA3 CD2AP FOXA2 IGF2BP3 SLC37A4 DSN1 ZCCHC10 PPIG SLK up
## EGFR_UP.V1_DN 0.0011947 0.0097297 0.4093038 1.783951 0 166 TMPRSS3 TTC39A SLC1A1 TCN1 IFI6 NME3 ANK3 PRPF6 ARMC9 GPER1 BDKRB2 HERC6 EPS8 MEX3D METTL3 BST2 DDX60 TSPAN5 AGL IFI27 RPP25 ZNF273 ASCL1 GTF2I IFI44L FTO FAM50A IRS1 KIAA1324 OVOL2 KRIT1 NET1 PRR7 GRB10 SPTBN1 IFI44 TAF12 MOCOS GOLGA8A CELSR2 NUP205 BDH1 CTSH PRR15L DLC1 TRIM24 ZNF107 RHOBTB3 CALCR PSPH STIL E2F8 BTG3 POT1 TMEM106B SLC39A8 SH3GLB2 SMAD7 SNX7 SIGMAR1 up
## PKCA_DN.V1_UP 0.0012330 0.0097297 0.4084236 1.743704 0 141 DKK4 VWA1 GATA4 SLC6A20 LCT CES2 ZFPM1 SMPD3 OAS3 DDX60 SPNS2 TCHH PCK1 CDR2 TUB EGR4 HOXB4 SECTM1 ZBTB7C CA2 PPP6R2 TEF REG1A LTB4R SP6 TTI1 BBOX1 RETSAT ADORA2B PER2 CXCL17 LPAR3 OAS2 ALOX12P2 DHRS1 GSTA3 ACHE PAQR7 TUBB2B GFAP AGXT TSKU DLX1 CMTR2 PASK GSTA4 S100G NRG4 CELA3A ELMOD3 GSTA2 MGMT ZNF865 RTBDN PSMC3IP ICAM5 SLC27A2 up
## EIF4E_DN 0.0012870 0.0097297 0.4225317 1.729141 0 94 TP53BP1 MYO10 ARHGAP32 SNAPC1 PLEKHA5 FRMD4B TP73-AS1 VPS13C SVIL NCOA7 CD55 SH3YL1 CLDN23 GALNT5 ARID4B LRBA EP400 PTGS2 FUCA1 MYH10 PRRC2C SGPP2 CNKSR3 MCPH1 EPDR1 DCTN4 GATA6 SIK3 LMO7 MAP3K5 DIP2B ESRP1 TRIP11 SORT1 ANGPTL4 LOXL1 NCOA6 TSPAN6 C2CD2 ADAM9 RANBP2 MIOX OFD1 WDFY3 NEDD4L DOCK1 TRIM47 PHIP CCAR1 up
## RPS14_DN.V1_DN 0.0011947 0.0097297 0.3928482 1.717222 0 172 TBRG4 REPS2 TLN2 EPB41 MRTO4 SH3TC2 AGAP1 ZNHIT2 SLC29A2 IPO4 TUBGCP4 LGR4 PES1 PCK1 CDR2 MACROD1 GEMIN4 EYA3 RPUSD2 TUBB2A MRPS2 AGFG2 EIF2B3 LRRC20 THEM6 NLE1 PRMT3 TUBG1 EPCAM ZC2HC1C MYH10 C14orf132 RPS28 DOCK9 ZNF74 CHAC1 CD320 ELMO3 PYCR1 TUBB2B SLC25A21 STEAP3 E2F8 SRM GPATCH4 PLK1 SRD5A3 GSTA4 ASNS RRS1 ATAD2 IL15RA GATC ISOC2 GINS2 MRPL12 MYO19 NDC1 GCDH INCENP up
## MEK_UP.V1_DN 0.0011947 0.0097297 0.3921908 1.709364 0 166 ISG15 USP18 TTC39A TCN1 IFI6 OASL IFIT1 GNL2 GPER1 UTP14A LRIG1 HERC6 QPRT METTL3 OAS3 BST2 RALGAPA1 DDX60 IFI35 AGL IFI27 ASCL1 AUTS2 IFI44L FTO GDAP1 IFT57 KIAA1324 ASS1 PRMT3 IFI44 MOCOS GOLGA8A DDX58 OAS2 OAS1 DLC1 KCTD3 ZNF107 AQR RHOBTB3 GOLGA4 CALCR PSPH IFITM1 IRF7 ELOVL6 POT1 IFIT5 ATP8B1 SMAD7 TDRD7 UBE2L6 PRKAR2B DCAF6 ANXA9 RMND1 TCF12 F12 IFIH1 HIRA AMIGO2 INPP4B ABCA12 up
## MTOR_UP.N4.V1_UP 0.0011751 0.0097297 0.3820607 1.685750 0 183 GALE USH1C RPAP1 LPCAT4 CASR TBRG4 SPRED2 IDH3A CCDC86 ASPHD1 LIMA1 LHX2 TRIB3 SLC7A5 PLS1 TIMM44 CLPB COASY PTPRK GFPT1 LDLR DHCR7 TUBB2A TRAF3IP2 PLCB1 EIF2B3 CALML4 CDK16 MAST2 SLCO4A1 RRP9 ASS1 NME7 ACACA IFRD1 SLC39A14 YRDC ETNK1 BHLHE40 MCPH1 CHAC1 EBNA1BP2 PYCR1 DDIT3 GALK2 CNIH4 PSPH SAR1B ELOVL6 PDHX PJA1 STX4 ADARB1 PHGDH GH1 ASNS SLC6A9 RRP15 ULBP1 ISOC2 GAS2L1 ADAM9 PHACTR2 OGN KIF21B PCK2 SLC3A2 up
## GCNP_SHH_UP_LATE.V1_DN 0.0011947 0.0097297 0.3855759 1.681164 0 167 LGALS4 ATAD3A ADCY9 EEPD1 WWC1 AXIN1 CLRN3 WLS UBE3C NTHL1 ZNHIT2 PTPRU EIF6 ZFYVE19 MLLT1 WIPI2 MIIP EPB41L4B LSR ZDHHC5 ACVR1 STX3 SNX21 NCOA7 RMDN3 AGTRAP PIP5K1A DSCR8 SH3BGRL2 IL4R ACTN4 HTR3A SLC2A1 PAK4 WNK2 CLCN6 FAHD1 CSF2RBP1 BCL2L2 DLG4 GPR3 PUS1 PITX3 ESRP1 PITPNM1 PDZK1IP1 TCEA2 NCOA6 CDCP1 SSBP4 DDA1 B3GAT3 NUDT1 MDFI ART5 COX6A2 PLD2 RAB34 UBE2V2 NDUFA10 ARAF FRRS1 CDHR5 MED12 TTC23 PTPN18 GRB7 PDCD7 RBBP6 EYA1 MUC3A DHODH up
## RB_P130_DN.V1_UP 0.0012788 0.0097297 0.4006677 1.678615 0 114 GC KAZN VSIG2 ZBTB17 POLD2 SIM2 ICA1 GFER PCSK5 SULT1B1 NSMCE1 DCTPP1 GLIS2 ENKD1 FAM220A AQP5 SNRPB GRTP1 TINAG RIPK3 RUVBL2 USP13 SGSM3 TRAF4 KIF22 ELOF1 RAD51D RSPH9 OXLD1 ART1 TEAD1 TWIST2 CRB3 EXOSC2 LSM4 HINT1 C12orf10 up
## CRX_NRL_DN.V1_DN 0.0012706 0.0097297 0.3964144 1.665103 0 115 TRAPPC3 METRN KAZN WWC1 RNF25 INPPL1 AP2B1 HES5 TNFRSF12A NTN4 SDC4 CLPB SLC25A51 ELOVL7 CPLX2 PRMT1 GTF2I HS3ST1 SPINT1 GDPD3 TMEM87A TNPO2 C14orf132 SALL3 GGT7 CITED1 FMN1 LRRC4 ENC1 SLC26A4 RAB27B SLC25A13 PTPN13 ACBD6 GABRA2 QSOX1 TMEM106B ATOH7 CAMK2B ECE1 RREB1 BAX PAM PNP TMEM158 FZD5 EYA1 ASPH LSM12 BSPRY RBP7 up
## RAF_UP.V1_DN 0.0011848 0.0097297 0.3784242 1.662818 0 181 TFF1 TMPRSS3 TTC39A PPM1E DIDO1 SLC1A1 SCUBE2 TCN1 MYO10 TSPAN3 ARMC9 GPER1 SHROOM2 LRIG1 BTBD3 PKP4 AGR2 EPB41L4B PLS1 RRN3 ASCL1 CRABP1 GTF2I AUTS2 ABAT TFF3 CASK DLG5 FTO ZHX2 PLCB1 IGFBP2 GDAP1 IFT57 IRS1 KIAA1324 SOX9 SYTL2 GPATCH2 TFAP2A ZNF32 CELSR2 ENAH DLC1 SLC19A2 KITLG SOX4 RHOBTB3 CALCR ALCAM PCGF3 up
## PDGF_UP.V1_UP 0.0012563 0.0097297 0.3893179 1.651437 0 133 PSMC6 TJP2 EXOSC10 MPI PPP1R37 SLC7A5 MORC2 GLOD4 PEX11A JOSD1 NUP160 EZR ZBTB18 SNRPD3 MADD PSMC3 ATXN2 VPS39 TAF12 RNF4 GPSM2 MAPK6 TFIP11 CHKA PFKFB3 CITED1 HDAC4 LAS1L SLC30A1 SNRNP40 CBX4 FOSL1 ZNF394 MRPS11 RAB35 RAB40B NDN ATXN7 URB2 SLCO3A1 MBTPS1 HDLBP GADD45A SNRNP35 ADAM9 LRPAP1 THOC2 ZNF460 ETFB BICD2 UAP1 FKBP2 TMEM158 FDX1 up
## BMI1_DN.V1_DN 0.0012658 0.0097297 0.3887695 1.642153 0 124 TFF2 PCDH8 IFI6 TRIM2 PRPF6 FAM76A ARHGAP12 BST2 DDX60 PLS1 MSX2 IFI27 CLDN16 GTF2I IFI44L TRAF3IP2 EEF1A2 MVP CA2 CTNNBIP1 PIK3R3 GPD1L SOX2 KANSL3 WDR25 TFAP2A TSPAN1 PLEKHA4 CITED1 TSPO ISOC1 PID1 IFITM1 CHMP2B LPAR2 HOXB13 LMO3 ESRP1 up
## E2F3_UP.V1_UP 0.0011891 0.0097297 0.3723891 1.629134 0 171 MFHAS1 SNRNP25 CMPK2 MBOAT1 CABLES2 CCP110 TPPP TMEM201 MNX1 SBK1 NGEF LRRC45 NUDT22 TSPAN5 DDAH1 RTN4RL1 PDIA2 ANKRD18A SLC6A2 HEY1 FGF9 EEF1A2 BRI3BP CYP26A1 EMC9 MANEAL FEN1 ZNF703 POLE SMAD6 GPR160 KLF16 FANCA PDXP SAMD11 FBXL16 CDC20B JPH1 TLCD1 PXMP2 TP53I13 ZIC2 UGT8 MMP15 SOWAHA ZDHHC12 FAM222A ZDHHC23 PCNA NPAS1 REEP1 PYGO1 ANTXRL PTCH1 ATAD2 TMEM106C ZNF483 DHRS13 SLC4A3 SH3BGR SLC27A2 GAD1 TLE2 ATRNL1 TSHZ1 PIN1 POLE2 SAMD1 EGLN1 TMEM158 HRK FAXC up
## RAPA_EARLY_UP.V1_DN 0.0011947 0.0097297 0.3735589 1.628769 0 167 TAF4 NUMA1 OSBPL2 PRKCE ZNF3 GABRB1 MID1 MARK2 MICU1 CRY2 IFI27 SF3A2 LGALS3BP COL9A2 GDPD5 CHKB STK11 GALNS FTO OVOL1 BCKDK ABTB2 FARP2 WFS1 SNAPC4 DUSP14 WDTC1 HLCS GRIN1 INPP5J SLC9A3R1 ESRRA PSMA7 ATG2A TFAP2A KDM4A SNTB1 KRT4 YIPF2 PINK1 LMNA CCDC85B BRMS1 EDDM3A PISD CBX4 NFE2L1 TRIM22 CACNB4 EPHB4 WNK1 DPH1 CIB2 PDZK1IP1 MYCN MET CDH12 BCAT2 XRCC1 MTMR3 PTCH1 SPRR1B ITPKC GNRH2 LHB SEC16A COL10A1 SLC22A14 up
## RB_P107_DN.V1_DN 0.0012853 0.0097297 0.3863258 1.613122 0 113 BSDC1 ANXA4 TPRG1L RNF25 PMM2 BLCAP AP3D1 COASY ELOVL1 MYO1D NSUN2 SPG11 GUCA2A SRI GALNT11 PINX1 PLEKHA7 NME7 BIN3 LACTB2 LPAR3 EIF3C AKAP9 BDH1 CHAC1 LAS1L HSD17B12 TXN2 NFE2L1 SAR1B ELOVL6 COQ9 TXNRD3 PLK3 PDCD6 PTPN9 GSTA4 TDRD7 SIGMAR1 GNG12 LPCAT3 MOGS AIMP1 SYTL1 up
## TGFB_UP.V1_DN 0.0011976 0.0097297 0.3607450 1.578836 0 176 FGF6 MAPKBP1 TP53BP1 IFIT1 TF ISL1 SH3TC2 TBC1D22B BDKRB2 CCDC130 ZNF512B GNE LGR4 ZXDC FRMD4B TM7SF3 ZFP64 TRPM4 MRPS6 SAV1 RPP25 CLEC2B ZMYND8 HS3ST1 NRSN2 RGL1 PIK3R3 SNAPC4 OTUB2 IFIT2 IFIT3 EHF ANKMY1 C18orf25 TFAP2A RBM47 BCL6 DDX58 FAM13A ZNF74 PRR15L KITLG TBX19 SLC30A1 UGT8 PAQR5 NPAS1 ANGPTL4 PLXNA2 SMPD2 SMAD7 PTCH1 C19orf57 PGBD5 BET1L FANCF MN1 HSD3B2 MPPED2 RIMS2 ATRNL1 TLR5 MLYCD up
## NRL_DN.V1_UP 0.0025445 0.0165833 0.3859339 1.626491 1 123 DHRS3 RNF207 SPEN RFX2 STARD10 CNGA1 SLC29A2 STK35 PLAGL2 CDR2 SNTB2 KMT2C LAD1 GRIK5 NR2E3 TFF3 CNGB1 NME4 BBS9 NGDN CLDN23 DUSP14 GRTP1 GPSM2 IRF6 SUPT6H RHPN1 GNB1 KCNJ14 SAMD11 REEP6 ARHGAP10 NRL KLHL36 TCP11 NLGN2 PPARA CTIF GADD45A GALNT10 BCL3 B4GALT1 IMPG1 GALNT7 HIC2 ZC3H3 TNFAIP2 HAS1 STYX PROSER2 ALPL up
## BRCA1_DN.V1_DN 0.0025445 0.0165833 0.3790331 1.599622 1 121 SLC5A1 PPM1E BMPR1B PPP1R9A RSAD2 ICMT CDK11A C1orf159 PTH2R WDR60 IFI35 CARD10 CHD2 GPR157 MX2 FGF9 HSD11B2 C1orf116 EXOC6B SCNN1D RAB40C INPP5J KCNQ2 ITGB1BP2 KANSL3 SMPX ZNF32 FOXJ1 GATAD2A VAMP3 CYTH3 NDOR1 WFDC1 CNIH4 HHAT DPY19L1P1 ZNF668 GPR35 NYX SPG21 KMT2D STX10 GNRH2 up
## PRC2_EED_UP.V1_DN 0.0023810 0.0165833 0.3500558 1.533942 1 179 MFHAS1 THRAP3 ATP13A2 TBL3 PACSIN3 MAP3K6 PWP2 MVD BTBD2 TNS4 FZD8 TRPM4 ABCB9 TSC2 CLPB PHKG2 WIZ PRMT7 AP1G2 SLC9A3R2 LRRC20 BCKDK CA9 DDX31 ODF2 NYNRIN VAC14 SLC12A4 XRCC3 ABCB8 HIVEP3 CDK18 CHAF1B RANGAP1 TACC3 MICALL2 RNF19A ALG12 WFDC1 MIA TAF1C CLSPN PLK1 SLC35C2 USP20 EXOSC2 DNAJB2 MISP TCIRG1 PNPLA3 SURF2 LIPE AMDHD2 ANKZF1 APLP1 UTRN TRMT2A INCENP PAGR1 GSDMD JUP ARHGEF17 LSS SP1 RAD54L POLD1 NUP188 TOP3B QTRT1 DBF4B CASKIN2 POLA2 TNK2 TUT1 BBC3 BTBD7 ERCC2 GALK1 NDRG4 KIF23 IDH2 up
## AKT_UP_MTOR_DN.V1_UP 0.0023895 0.0165833 0.3481467 1.517398 1 166 GIPC1 IFIT1 GDE1 PACSIN3 HOXB3 SUSD4 HOXB5 TACSTD2 MICU1 MYO5B MLLT1 GUSB LRG1 TNFRSF12A CLMN PLAT VILL DHCR7 MVP MPP2 CD55 PAK1 TJP3 ZNF746 SH3BGRL2 ELL TMEM186 DUSP8 DAGLB CXCL5 GAK SYT17 ADORA2B DHCR24 ZBTB21 PDZD11 TPRN KCNK5 MAL2 GSDMC SNHG11 ALDOC RNF41 DUSP10 MYCN GGA1 PFDN2 ABCA7 C3orf52 SLC39A8 GPD2 A4GALT UBE2R2 PON2 CAMKK1 BMP8B FBXO6 HIC2 BACE2 CALCB SUCO CDKN2B up
## YAP1_DN 0.0028860 0.0181818 0.5026386 1.748606 1 40 SLC9A1 CCDC87 FAM122C HEY1 CHCHD3 PDIK1L IL4R PIGO THNSL1 TSPY26P PRCC KATNB1 RHBDL1 RFX1 GUCY2C CACNB4 ITGA2 APOBEC2 LINC00639 SLC17A7 up
fgsea_plot(fgsea_res$res_c7, pathways_title='C7 immunologic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## -------------------------------------------------------------------------------------------- ---------- --------- ---------- --------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GSE6269_FLU_VS_E_COLI_INF_PBMC_UP 0.0011834 0.004885 0.5590723 2.411797 0 153 ISG15 USP18 GLYR1 RNF40 IFI6 SLC4A2 OASL C2CD3 GSE1 RSAD2 KCTD13 XAF1 MX1 HERC6 MARK2 OAS3 CAPN15 DDX60 IFI35 PKM NFATC2IP POLM AP3D1 SZRD1 AGRN OGDH LGALS3BP GTPBP2 MX2 CMTR1 DNAJC4 SREBF2 IFI44L USP10 UBA1 SPATS2L TRABD IFI44 CHST12 VPS39 ACTN4 HECTD3 GAK ACIN1 NPIPA1 PI4KB ARPC1A OAS2 SZT2 PARP12 SUPT6H OAS1 DCAF15 N4BP1 DNM2 ATP13A1 BPTF SMG7 EIF2AK2 SHC1 IFITM1 CXXC1 IRF7 GPATCH8 TRIM21 PDHX ADAR MYO9B STRN4 C16orf58 SART3 NCOA6 EIF4G1 DCTN1 LARP1 PURA PHACTR2 EBAG9 up
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0011534 0.004885 0.5347527 2.366356 0 187 NOC2L UBN1 AURKAIP1 SRRM1 AMBRA1 E4F1 TAF4 TBL3 LPCAT4 OSBPL2 ZBTB17 PEF1 ADRM1 POLD2 DNAJC17 LRRC41 SLC7A5 ZNF512B SLC2A4RG CDC37 CFDP1 NAA60 TSR3 NADSYN1 PTBP1 SF3A2 SLC25A22 SIGIRR TMEM259 MRPS2 THOC6 XAB2 ABCF3 PPP6R2 VPS51 TSTA3 HRAS COPS7B TAF10 AAMP CDCA4 SART1 MARCKSL1 AP5Z1 UBE2M ANAPC2 RPL36 WDR18 PRCC SSRP1 TRAPPC2 GATAD2A TRIM28 STK25 DCAF15 TACC3 CCDC85B BRMS1 EXOC7 HSPA9 NONO RPLP2 HMG20B PSMB10 ATP13A1 MFSD10 RPL11 C9orf16 U2AF2 PRPF19 GADD45GIP1 TAF1C FUS SMARCD2 POLR2E PDLIM2 VPS9D1 FOXK2 PFDN2 NELFB TNFRSF14 THAP7 SH3GLB2 ATP1A1 DRAP1 RRS1 DGKZ PDAP1 RALY DAZAP1 RALGDS RPS27 STARD3 EDF1 SAFB2 KLF13 CCS SPINT2 EEF1D MRPL12 GCDH PIN1 NDUFC1 TP53 AEBP1 ABHD17A SRSF9 LSM12 PDIA4 up
## GSE16385_MONOCYTE_VS_12H_IL4_TREATED_MACROPHAGE_DN 0.0011587 0.004885 0.5138868 2.265308 0 183 TBX6 UBE4B GLYR1 GSE1 ZNF777 ZBTB48 UCKL1 PPP1R37 AP2B1 NIPAL3 MEX3D ANKRD54 CENPT FASTK MIIP TUFM VAPB ABCB9 ZNF384 LMF2 ATXN2L AP3D1 ARID1A MAPK8IP3 RNF31 TMEM259 EYA3 PPP1R12C NEIL1 AUP1 GUCD1 CPSF7 DNAL4 RPS6KA4 PHRF1 SNAPC4 HDAC7 TRABD TOMM34 ANKS1A CPT2 RNPEP KANSL3 TBC1D9B WHAMM PCYT2 STRIP1 SH2B1 TFIP11 GNB2 CLCN7 LRP10 POLRMT TSC22D4 RHBDL1 FHOD1 MRPS35 RFX1 HMG20B THBS3 DLST MAGI1 PITPNM2 TRIM11 CIZ1 CHRNB1 RAPGEF3 STX4 PDLIM2 MAP3K11 RAB35 MORN2 MAFF BFAR KLHL36 STRN4 ABCA7 ZFAND2B NELFB XRCC1 FGF8 PPP2CB RALGPS1 LIPE PELO CHD4 MAP4K2 TESK1 ADIPOR1 PRRC1 up
## GSE32034_LY6C_HIGH_VS_LOW_MONOCYTE_DN 0.0011574 0.004885 0.5049609 2.237220 0 190 USP18 PGP CDK11B KIF1B CMPK2 RNPS1 NRG3 AXIN1 PRPF6 RANBP10 HOXA11 FBXO22 CRY2 AVL9 BST2 STUB1 CAPN15 DDX60 ZNF764 RBMX2 IFI35 FAM207A MIB2 RRN3 NSUN4 ATP6V0D1 AGRN LGALS3BP COL9A2 CHKB RRBP1 OLFM3 XPO6 NXT1 PPP1R8 RELA DUS1L OSBP RAB40C LONP1 IFIT2 IFIT3 CELSR1 SART1 RNF114 EIF3D PARP12 PARP14 RTP4 TDRP DAP3 TRAF4 SFSWAP OAS1 RNF11 PITHD1 CTDP1 NGRN LAS1L ALKBH4 NDUFS6 ENC1 GRAMD1A FOXJ3 MARVELD2 LCMT2 RPP25L TXNL4A VPS16 NEK9 XDH ZNF394 POP7 SOWAHA SPRTN PITPNM1 MPDU1 HAUS8 HEATR1 GTF3C4 PTOV1 LARP1 HARS2 TNFRSF18 TSTD2 GOLGA5 SEC61G up
## GSE22432_MULTIPOTENT_VS_COMMON_DC_PROGENITOR_UNTREATED_DN 0.0011669 0.004885 0.5013252 2.201188 0 179 DNAJC16 TBL3 MRGBP TELO2 INO80 PPFIA1 FDFT1 CC2D1B ILDR1 NIP7 GFER GUK1 PWP2 REV1 NOC4L ALG8 TSEN54 RTN4RL1 MYBBP1A RRN3 MRPL55 LETM1 PEX11A DPH2 CTU1 APRT PRMT7 TNIP2 PDIK1L NUDC RSL1D1 FAM50A DDX51 PTGES2 C19orf48 TMEM177 EIF2B5 MNT SF3A3 BOP1 BAG5 MARCKSL1 RUVBL2 TPD52L2 HIVEP3 DDX49 TRAF4 SNHG7 TFE3 CBFB TSR1 SLC19A2 RNF126 PGAM5 DDX56 C7orf26 ATP13A1 TLCD1 CAMSAP1 GSTT2 PRPF19 HIRIP3 ECE2 ATXN7L3 CMTR2 DOHH ZNF106 BFAR PCNA MORF4L2 NAA20 RCE1 MAGOH PTCD3 FAM126A MAP2K3 PURA CHD4 BTBD19 BZW2 DDX10 up
## GSE45365_WT_VS_IFNAR_KO_CD11B_DC_MCMV_INFECTION_UP 0.0011669 0.004885 0.5007241 2.183872 0 168 GIPC1 SRRM1 RPAP1 EIF3B CABIN1 DISP1 NTHL1 MAP3K6 YDJC CAPN15 NOP2 CLPX MYBBP1A BCL9L AMH NSUN4 SOBP TRMU LETM1 UQCC1 LMF1 EZR WIZ SNX8 RRNAD1 ZNF786 RPTOR RCN3 KRI1 ZBTB7A RRP9 PINX1 PRPF8 DUSP14 CACTIN VAC14 TNPO2 ESRRA AZGP1 HECTD3 TMEM150A TRIM3 CLCN7 TCEA3 NAT9 TSR1 RRP7A EXO5 UBTF POLG PELP1 ALKBH4 TTC9 ALG12 RIN1 TAF1C ZBTB40 HHAT MYEF2 IDUA PPP1R13B KLHL36 GLO1 PPIL2 RCE1 PRR12 EPB41L4A ARHGEF18 MBTPS1 ANXA2P1 CCDC61 TCOF1 SURF2 DPP9 GLCE APOD CHD4 NF2 BET1L OSBPL5 SLC35E4 NEURL4 IMMP2L ALKBH5 DCAF6 CCDC142 RNF26 ZNF79 IVD up
## GSE6269_FLU_VS_STREP_PNEUMO_INF_PBMC_UP 0.0011792 0.004885 0.5007655 2.172252 0 163 ISG15 USP18 GLYR1 IFI6 OASL C2CD3 IFIT1 ZNF609 RSAD2 SMARCA4 REC8 AKAP1 XAF1 MX1 HERC6 MARK2 LY6E HMGXB3 UBE2D4 OAS3 DDX60 PML IFI35 SMG1 NFATC2IP AP3D1 LGALS3BP KCTD14 MX2 CMTR1 IFI44L SPATS2L PARP2 SBF1 IFIT3 IFI44 CHST12 ACTN4 ESF1 OAS2 PARP12 RTP4 ILF3 OAS1 DCAF15 N4BP1 OARD1 BPTF SMG7 EIF2AK2 IFITM1 TRIM22 MKLN1 IRF7 GPATCH8 GLG1 PSME2 PDHX STIL ADAR SON C16orf58 DESI2 SART3 ZNF264 EIF4G1 UBE2L6 PURA PHACTR2 CHD4 HERC5 RPL28 NF1 THOC2 COX8A TYMP IFIH1 EIF5B CHMP5 NCOA3 CD2AP JUP TNIK TAF1B ST3GAL5 RHBDD3 up
## GSE19888_ADENOSINE_A3R_INH_VS_ACT_IN_MAST_CELL_UP 0.0011641 0.004885 0.4934140 2.166729 0 178 GSE1 TUBA8 WWC1 POLD3 NIPAL1 HMGA1 ZFPM1 HOXB5 SC5D ZNF598 TMEM54 NR2F6 ANKRD54 LSR ZC3H18 CSNK1G2 LETM1 AIMP2 RAB25 CDC42EP1 SEPHS2 EVA1A NEIL1 MUL1 MRPS2 MED19 FBRS DUS3L HRAS ESRP2 MAP1LC3A EXOC3 PRDM2 KXD1 TUBGCP6 TMPRSS13 PYCR2 MIDN NACC1 COX19 LRP10 SNX12 NINL RHOD PYCR1 CKMT1B MTHFSD PPARD ARL6 AJUBA URB1 IGSF9 SPATA5L1 MAP3K11 EVPL ZCCHC17 PPP2R5E C3orf52 TMEM183A DNAJB2 EMC10 GADD45A FAM89A RALA ALYREF XPOT DGKZ ATAD2 PCDH1 PKP2 SIPA1L1 UBE2R2 ABLIM2 TBP TSPAN9 IST1 SYTL1 FRRS1 ARF6 TCF12 BLOC1S3 AP4S1 up
## GSE40274_CTRL_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN 0.0011891 0.004885 0.5038864 2.162653 0 148 PIK3C2G GNG4 PUSL1 OASL SESN2 PRR15 URGCP TBRG4 SYTL5 POLR1C IPO4 POMC FOXO6 GUK1 ARL14 PIEZO1 CRLS1 REM2 PEX14 SUPT3H FAM207A ZMYND19 SIX4 CCNO NOL9 HOOK1 CHPF OVOL1 THOP1 SLC9B2 RSAD1 PPP1R16A GIT1 SLC35B2 TMEM200B PICK1 DHCR24 SCIN C7orf50 RTP4 TOMM22 GTF2F1 HOMER1 PSPH PIP5K1C MRPL11 SLC25A39 AACS MCRS1 APOBEC4 ECE2 FOXRED2 SLC52A1 SRM UBE2U POLR1B NDUFC2 PLK3 PFDN2 TMEM183A STK19 WDR17 SMARCB1 IL15RA VEGFB GOLGA5 ART5 POU5F1 CCDC9 NETO2 AIMP1 up
## GSE32255_WT_VS_JMJD2D_KNOCKDOWN_4H_LPS_STIM_DC_DN 0.0011962 0.004885 0.5045887 2.158312 0 146 SLC12A2 SNORA74A TBL3 HELZ2 YTHDF2 ZBTB48 FDFT1 INTS5 FEM1A BLCAP CDC34 NOP2 EFCAB14 SUCLG1 ENO1 MX2 NDUFS4 SEPHS2 DFFA PALB2 TP53RK RMDN3 TRMT1 GRPEL1 ALDH4A1 EMC9 DHX37 IFIT3 ITGB1BP2 MGME1 SLC39A14 IPO13 HDAC9 TPD52L2 PRCC GFOD2 PPP2R5B TRIM28 NDUFS3 FHOD1 ATIC RPL3 ZBTB7B SENP8 DAPK1 SNORA44 HOMER1 PATZ1 RPP25L POMT2 WDR78 TCF20 STOML2 ACER2 NDUFC2 CAMSAP2 DCPS TUBB4B USP31 GSTA4 BANP SH3GLB2 PPA1 TDRD7 BUD13 SPEF2 RPS27A PTK6 DAZAP1 HERC5 SIPA1L1 up
## GSE41867_DAY6_VS_DAY8_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN 0.0011641 0.004885 0.4887048 2.154688 0 185 MFHAS1 NOC2L FAM118B SRRM1 RPAP1 NOB1 LYPLA2 LIPT2 UBAP2 CTH NUTF2 UBE2I EIF6 WDR73 MTRR SUPT3H MDN1 TRMU HAGH AIMP2 TADA2A MTG2 UBOX5 USP10 FTO NUDC NLE1 TIMM22 SNRPD3 DUS1L GRPEL1 TMEM177 NSFL1C MRPL17 SLC35B1 DPH6 IFRD1 MRPS26 PPIE AHCY SRPK1 CHAMP1 HNRNPLL PHF5A ZNF213 NDUFA4 ACTR10 GPS1 DDX49 SNHG7 TOMM22 BLOC1S4 TRMT112 SWAP70 TRIM44 PPRC1 SPATA5L1 TIMM8B SLC25A39 ELOVL6 POP7 POLR2E RAD23A LZIC YWHAG ACOT7 USP31 EXOSC5 RCE1 DDX39A JMJD4 MRPL52 N6AMT1 NCOA5 MSRB2 MCM3 COPS6 BTBD19 BZW2 DDX10 C19orf53 MSRA UBE3D TMEM209 PAK1IP1 DNAJC2 SRP54 CCT5 CDK4 NDUFB9 EEFSEC NUP188 NDUFS7 AEN SPRYD4 CLDN7 TBC1D10A SPAG7 PSMD13 TFPT UTP3 CD3EAP TIMELESS TMEM69 DYNLRB1 SF3B5 FUBP3 NOC3L SLC25A38 C1orf50 DNPH1 FASTKD2 NME1 IPO5 VCPKMT IBA57 DCP1A COPS7A LSM7 POP1 MED30 up
## GSE27786_LSK_VS_NEUTROPHIL_UP 0.0011641 0.004885 0.4881955 2.143812 0 178 ATP13A2 CYB5B MECR TTLL12 FNBP4 CC2D1B POMGNT1 TUBGCP5 NPRL3 CAPN2 METTL3 ST14 RAMP1 GNAS NUDT12 DLG3 TSEN54 LUC7L SOX6 LMF1 TRAPPC12 RAI1 HOOK1 C12orf75 SCAF4 TIMM22 DUS3L HAGHL KDM1A RRP9 KIF3A TMEM177 MRPL28 LONP1 PLEKHA6 TRIM45 GABRR1 CBX6 GSTK1 LRRC1 AKAP9 RRP1 DBP PSMD12 ARHGAP21 IWS1 RPS11 DGCR8 RPA3 PSMB10 MAP1S CSTF2 TXN2 PPM1G FAM133B LDB1 MYEF2 SLC25A13 RNF220 DTNBP1 POT1 ZMIZ2 NUP133 C16orf58 LRP6 LSM4 NDUFA9 DPP7 THYN1 RCOR3 NUP214 NSMF MAP2K5 RPS27 HMG20A EXD2 SLC22A5 IMMP2L GLRX3 FLNB UCK1 STYX ZFAND1 RCAN3 C11orf74 USP37 SAE1 SLC37A4 MZT2B RBM14 BRMS1L PHF20 FPGT ZSCAN22 GLRX5 SCFD2 up
## GSE33162_HDAC3_KO_VS_HDAC3_KO_MACROPHAGE_UP 0.0011601 0.004885 0.4848079 2.134076 0 180 EPHA5 B3GALT5 REG4 USP18 TBX6 NME3 AXIN1 PRPF6 TPBG MARK2 PMEPA1 PWP2 MAPK8IP1 OAS3 BST2 STUB1 ANKS3 GTPBP1 DDX60 ZNF764 IFI35 BCL9L PCK1 CLIP1 AIMP2 TRAFD1 AGRN LGALS3BP PSMG4 VILL CMTR1 ZBTB8A SRRT IQCC BNIP1 OLIG1 PLA2G12B HOOK2 IL4R ASS1 RAB40C TMEM186 LONP1 PSMC3 PPP1R14B PTGES IFIT3 TOMM34 PRPF38A TFIP11 PARP12 PARP14 RTP4 SGSM3 SUPT6H SCYL1 CITED1 TRAF4 OAS1 LMNA FBXW9 MEPCE ACHE PSMB5 CAMSAP1 ERBB3 POLR2E UGT8 CIAO1 ZDHHC12 TXNDC11 ZMIZ2 ZNF264 CDCP1 RRP15 PTOV1 RREB1 ATG4D SIGMAR1 MCM3AP HTT STARD3 RPS9 NUBP1 SLC22A5 MOGS ARHGEF12 PARP9 INPP1 GBP6 SMG6 TNFAIP2 SIDT1 CA8 CYB5R1 ANKRD40 ZNF574 KEAP1 up
## GSE20715_WT_VS_TLR4_KO_6H_OZONE_LUNG_DN 0.0011641 0.004885 0.4838834 2.124877 0 178 SRRM1 HERC2 RFX2 TMPRSS2 SOS2 RP9 WDR90 INTS5 SIN3A CYSTM1 CLUAP1 SCGB3A2 STUB1 CAPN15 DLG3 UBE3A BCL9L HAGH EFNA1 SF3A2 MROH1 XAB2 NUDC TNPO3 HS3ST1 JTB TM9SF1 NME7 WDTC1 ARID4B AAMP TEKT2 CDPF1 NFYC THNSL1 SOX2 AP1M2 KLC3 SIN3B CEP70 NAT9 LMNA LRPPRC LAS1L AQR CBX4 MED16 CHPF2 HEXIM1 ELOF1 RSPH9 SLC16A11 EIF3G APPL2 HES1 ESRP1 OS9 UTP20 HIBADH NRDE2 CLDN8 SNHG8 MSL1 XPR1 PKDCC GAS1 TCP11 LRRC49 SUMO3 DCTN1 SSBP3 CP NOSIP CSNK1D FLCN BPHL JUND RPS27 CYP27B1 PIGR CNOT4 NFKBIZ RAB34 CAMTA2 WDR33 IST1 SLC25A36 ARF6 OXT SEC24C AEBP1 SPATA13 CDIP1 DYNLT1 SPA17 PPIG up
## GSE15624_CTRL_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_DN 0.0011848 0.004885 0.4918738 2.124361 0 155 DNAJA3 TRAPPC3 TMEM238 NADK LRWD1 FDFT1 ERI1 GAN DGAT2 IPO4 PWP2 LRP8 TAF6 CDC37 MYBBP1A PHLDA3 RPP25 PSMD11 PGAP2 BCKDK RMDN3 XXYLT1 SNRPD3 DUS1L CELF1 SPRED1 SLC12A4 BOP1 C3orf33 CCDC127 TUBG2 TRAPPC2 HSPBP1 NDUFS3 FBXW11 CHAC1 IMP3 C19orf67 SLC26A6 PPM1G PPRC1 TRIM21 PSME2 UBAP2L ADARB1 ECSIT SEC23B MPDU1 HIBADH TRAP1 PLEKHA8 ANGPTL4 HEATR1 SLBP SF3A1 SLC39A8 ECE1 RRP15 C19orf57 DPP9 GNG12 IMP4 SPATA24 PCK2 NEK7 HEATR3 COMTD1 IMMP2L EEF1D AIMP1 CPSF4 GLRX3 FIGNL1 KLHL26 PCNP MSANTD4 FARP1 ICK KEAP1 GNAQ ITGB1BP1 CHID1 SPRYD4 MRPL21 PACRGL SPAG7 EFTUD2 SND1 PDXK NUDT21 KIAA1191 CCDC6 RPN2 TMEM129 GYS1 PPFIBP1 ADO up
## GSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_AND_A3R_INH_PRETREAT_IN_MAST_CELL_DN 0.0011601 0.004885 0.4776505 2.107540 0 184 BAIAP2L1 SH3RF1 SRCIN1 RPAP1 FGFR2 SPINK2 C16orf70 NFAT5 NXN FAM83F PTPRU RANBP10 HMGXB3 STAP2 ZNF512B FAM160B2 FREM2 ANO9 PTPRF TNS4 SERTAD4 TMEM63A CDH1 LUC7L EFNA1 TRAPPC12 LAD1 RAPGEFL1 SRRT SVIL PRLR SPTAN1 DFFA ZBTB7C CHD8 GRHL2 SNAPC4 RAB40C ABCC1 RHBG PTPN14 MICALL1 CNNM3 MKRN1 TFAP2A ZNF692 CELSR2 TMCO6 TNK1 PERP DDR1 NEAT1 FAT1 CKMT1B HDGF GOLGA4 ANKRD16 AJUBA RIN1 CDC42BPG ERBB3 SH3D19 SMARCD2 ESRP1 AGO1 AGO4 STRN4 PRRC2B C3orf52 CDCP1 ARHGEF18 SMAD7 TMEM216 DGKZ TAZ RPL28 RPS9 SERBP1 HMG20A SPINT2 CAMKK1 DAG1 TSPAN9 SPPL3 CHDH UPF1 TLE2 ARID1B ATRNL1 TANC1 ARGLU1 FAM193B GRB7 CYC1 SDC1 RCAN3 METTL17 MEF2D PLCH2 SFT2D2 up
## GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_DN 0.0011601 0.004885 0.4753261 2.097284 0 184 EIF3B MNAT1 FAF1 CTU2 TBL3 MTOR NADK LYPLA2 GNL2 CLUH IDH3A FDFT1 ZNF768 CYP51A1 EIF3I SNHG3 CDC34 ALG8 TRMT61A ZMYND19 LETM1 CLNS1A BCKDK TSTA3 ITFG1 GRPEL1 LRP11 TCERG1 ACACA MRPS26 BOP1 AHCY PDZD11 HIVEP3 GFOD2 CERS6 LZTR1 UQCR10 LAS1L ZMYM1 GATAD1 TMEM51 RPA3 MRPL37 SLC25A10 NMT1 NDUFB7 CNIH4 NAT10 PPRC1 DUT EIF3G SRM NDUFV1 GPATCH4 PCNA SQLE EIF4G1 HDLBP HINT1 PTOV1 GCSH MAP2K3 MRPL23 PABPC4 ACADS ATP2A2 SMYD5 BZW2 NTMT1 FBXO6 UROD DDB1 PIN1 EIF5B UQCRQ LSS FDX1 CCT7 PHF23 LSM12 SUPV3L1 CDK2AP1 BSPRY POLR1D up
## GSE19888_NO_PRETREAT_VS_ADENOSINE_A3R_INHIBITOR_PRETREATED_MAST_CELL_TCELL_MEMBRANES_ACT_UP 0.0011601 0.004885 0.4762124 2.096240 0 180 FGF23 SLC5A1 INPP5B NOP9 ACD DDX19A ZNHIT2 BDKRB2 DGAT2 PKP4 PPP1R37 FBXL18 GMDS MPG C16orf90 FASTKD5 BST2 TUFM TSPAN5 ZHX3 PARK7 ACOT8 NEK11 BCKDK CCNB1IP1 LAMA5 TRMT1 CUBN SCAF1 LBX1 TASP1 ACACA COMMD4 RNF4 FEN1 TATDN1 XRCC3 PAK4 MTR MT1E NUP205 SSRP1 DBP ERAL1 PITHD1 DHRS1 PTRH1 DGCR8 UTP18 MRPL37 SNHG11 PIGX LMLN HNRNPAB MARVELD2 FAM133B TAF1C FBXW8 KCTD11 MYPOP AAMDC FOXK2 GOSR1 TOMM7 BMP5 DNAJB2 SULT1A1 HK2 RRS1 C2CD4B NDUFA13 RASSF7 FAM185A USP21 LZTFL1 ATP8B2 MYPN SNRPD2 DTX4 TESK1 NETO2 KIF1C UBR5 up
## GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN 0.0011641 0.004885 0.4768922 2.094177 0 178 RAB11FIP3 DYNC1LI2 SNRNP25 POLR3K MARVELD3 SLC2A13 CCP110 MRPS34 DDX19A C16orf46 CTH SULT1A2 QPRT LRRC41 ZDHHC7 CFDP1 CDH1 CDR2 EMC8 NAE1 TRMU NDUFB10 FAM201A CDS1 LCMT1 APRT TNFRSF11A USP7 PRMT7 RSL1D1 CBY1 ITFG1 ANKRD11 SPG7 ZNF239 MRPL28 HOXC4 CDT1 LONRF1 CTCF EPHA7 KATNB1 KANK1 IQCH-AS1 CBFB TMCO6 TMEM208 TSPO ZNF276 AGPAT5 ECHDC2 ATMIN COQ9 ESRP1 DTNBP1 DEF8 ANKRD46 STOML1 SQLE SRD5A3 EFEMP1 SULT1A1 HSDL1 DDX28 VKORC1 AADAT C2CD2 MON1B ADAM9 GINS2 AGO2 MCM3 PHLPP2 PAM UBE2V2 TERF2IP ERCC4 ETFB BACE1 COX4I1 EIF4EBP1 TCF25 GPRC5B NDUFB9 CMC2 ARHGEF26 RBP7 ERLIN2 ZNF91 CHD9 up
## GSE13485_DAY7_VS_DAY21_YF17D_VACCINE_PBMC_UP 0.0011641 0.004885 0.4748993 2.093820 0 185 ISG15 USP18 IFI6 OASL IFIT1 RSAD2 REC8 RCC2 PPM1A XAF1 MX1 CTTN IPO4 HERC6 LY6E CAPN2 OAS3 ZNFX1 GTPBP1 USP42 DDX60 PML IFI27 ELF4 HMGXB4 MX2 CMTR1 LDLR WASL RAC1 PNPT1 IFI44L NCOA7 MVB12A SIPA1L2 RGL1 RELA SPATS2L MNT FNIP2 IFIT3 MIDN MGLL PKD2 RIN2 AKAP8 BLVRA OAS2 ODF3B PARP12 PARP14 CKAP4 OAS1 ARHGAP21 NCOR2 ZDHHC3 EIF2AK2 NPEPL1 SAT2 SAMD4A TRIM22 IRF7 PIWIL4 UBAP2L KIAA0513 RNASEH1 ADAR PTK2 MYOF TXNDC11 LINC00487 IFIT5 HAUS8 TRIM25 CHAF1A MAN2A2 SMAD7 ZCCHC2 MARK3 PHACTR2 HERC5 UTRN CLASP1 ETV6 DDX60L FBXO6 PARP9 USP25 MTHFR JUP TYMS ST3GAL5 SCARB2 AGPAT3 IGF2BP3 STAT2 TBC1D8 RCN1 ULK1 SCO2 APOBEC3A up
## GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0011614 0.004885 0.4753746 2.092301 0 181 AURKAIP1 SRRM1 LPCAT4 RNPS1 LRRC47 RBCK1 ADRM1 NUTF2 GID8 VPS4A MEAF6 ZNF512B CAPN15 CDC37 CFDP1 NAA60 TSR3 NADSYN1 PTBP1 SF3A2 ELF4 ADNP2 APRT MRPS15 CHCHD3 THOC6 MVP XAB2 VPS51 HRAS COPS7B DEAF1 TAF10 PPP1R14B CDCA4 SART1 MAP2K2 MARCKSL1 AP5Z1 AHCY WDR18 PRCC SSRP1 TRAPPC2 GATAD2A DDX49 STK25 CCDC85B RNF126 BTF3 HSPA9 NONO GTF2F1 RPLP2 HMG20B PSMB10 MFSD10 C9orf16 CBX4 MYH9 U2AF2 ILVBL ECSIT SMARCD2 POLR2E PDLIM2 IDUA FOXK2 PFDN2 HNRNPUL1 TNFRSF14 SH3GLB2 SUMO3 SSBP3 NSMF DRAP1 DGKZ PDAP1 C12orf10 RALY SEC61G DAZAP1 STARD3 EDF1 SFPQ SAFB2 BCL7C HNRNPR MRPL12 NDUFS8 NDUFC1 TP53 RDH14 up
## GSE43863_NAIVE_VS_MEMORY_LY6C_INT_CXCR5POS_CD4_TCELL_D150_LCMV_DN 0.0011614 0.004885 0.4731324 2.089432 0 186 TMEM248 NOP9 GIPC1 WRAP73 TBL3 MTOR UBE2J2 TBRG4 KCTD13 MTFMT MLST8 UBE3C C1orf122 USP54 FLVCR1 KPNA6 SLC41A1 WDR73 YDJC ECI1 CHERP NEO1 TSPAN5 TRMT61A CLIP1 LUC7L TADA2A AGRN ELOVL1 APRT PSMD3 DPP3 PNPT1 THOC6 EIF2B3 NDUFAB1 AK2 NUDC THOP1 CCNB1IP1 DDX31 PTGES2 DUS1L TMTC2 GIT1 C1orf53 MTFP1 TMEM150A ACIN1 GGA3 CHAMP1 ZNF213 CLCN6 SUPT6H HSPA14 TXNDC17 TRMT6 LAS1L REEP6 MAP1S ETF1 ZNF771 GTPBP4 TRIM44 NAT10 RABL6 AACS TMEFF1 MFSD5 SRM MAFF DUSP10 WDR3 WDR83 TMEM183A MAGOH RPS6KA2 PDAP1 PTPMT1 TPST1 NUBP1 BAX SCYL3 TESK1 NFKBIZ SMYD5 TIMM13 NTMT1 MRPS7 CSE1L TAF1A MYO19 PUS10 TMEM209 BOLA3 RBPMS2 PMPCB NHLRC1 up
## GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_ATOPIC_PATIENT_UP 0.0011641 0.004885 0.4753868 2.087565 0 178 SH3RF1 AKR7A2 WRAP73 RNF121 CHST4 GNL2 MRPS34 ATP10A ANXA4 BMS1 HDAC1 SLC7A5 EIF3I NR2F6 EMC8 PSMG4 SLC25A22 MTG2 UBE2O WIZ DPP3 JKAMP SCAF4 NME7 TAF10 MPP7 MGME1 SPRED1 RPS2 THNSL1 ABCB8 PRPS1 RRP1 SSRP1 HIVEP3 THUMPD1 RNF11 NMNAT1 FBXW11 TXNDC17 IMP3 SOX12 NUP88 FIBIN MFSD10 C9orf16 GALK2 HSBP1 TRAPPC13 CCDC107 DEF8 FEM1B TMEM183A NLGN2 XRCC1 HDLBP TCOF1 RAB27A IMP4 PELO PKMYT1 MDK HSP90AB1 CLASP1 MIS18A PPAN ANXA9 FDPS DDB1 NSUN5 EIF5B CHMP5 CAPRIN1 EEF1B2 KDELR3 PMPCB TMEM158 MRPS23 CYB5R1 UFC1 KEAP1 ASPH TAF6L DMAP1 NUP188 R3HCC1 CYP3A7 PEX3 NIT1 CPZ CHST2 EMC7 RBBP7 WDR43 NUDT21 PRKAG2 UTP3 CA5B PSMA1 NAA35 DPP8 PSMB4 NDFIP1 SLC4A1AP up
## GSE43863_TH1_VS_LY6C_INT_CXCR5POS_MEMORY_CD4_TCELL_UP 0.0011614 0.004885 0.4717774 2.083448 0 186 MFHAS1 NOP9 TRNAU1AP TBL3 MTOR SLC7A6 TMEM238 KCTD13 GLS SLC25A33 IDH3A HMGA1 UTP14A SF3B3 MLLT1 MTRR TSEN54 CLIP1 LUC7L AIMP2 TADA2A GEMIN4 ABCF2 WIZ INTS4 PSMB2 GRWD1 NSUN2 PNPT1 MRPS2 ARFRP1 EIF2B3 WDR55 B4GALT5 THOP1 CCNB1IP1 NLE1 DDX31 RRP9 PDF ZC3H12A IFNLR1 GMEB2 RUVBL2 WDR18 CHAMP1 C7orf50 GPS1 RUVBL1 RABGGTA TMEM184B PXN RRP7A TRMT6 ATIC DDX56 ELAVL1 PELP1 ETF1 PPP5C HOMER1 AATF SLC9A8 TRIM44 NAT10 PUS1 RABL6 CTPS1 ECE2 FOXRED2 STOML2 RBM17 SRM ATXN7L3 POLR3D LMNB2 TSEN2 URB2 NAA25 PDAP1 PTCD3 IL15RA PTPMT1 CFLAR HEATR3 SMYD5 CPSF4 GBP6 MYO19 PUS10 UTP6 SRFBP1 DNAJC2 SNUPN ICAM1 ANKRD40 ZNF770 LSM12 SUPV3L1 WDR4 CD44 BRIX1 HNF1B PHIP up
## GSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_UP 0.0011587 0.004885 0.4717842 2.079712 0 183 GABRP B3GALT5 PHACTR4 ZNF609 ARHGEF28 KRT14 DAPK2 INTS1 PML ANPEP PHLDA3 EPN3 TSC2 B3GNT3 CCNO PLXNB2 GNA11 GEMIN4 CNKSR1 VPS37B EPS8L2 SECTM1 RUSC1 UBA1 PKN2 RIPK4 CHD8 TRPC4AP LRRC14 KDM1A SPATS2L CAMK1D MEN1 SLC9A3R1 ZFHX3 CELSR1 ZNF500 ANAPC2 DDX27 EPHA7 CLCN7 KRT4 ZNF142 KRT19 ERAL1 CTDSPL CUEDC1 APLP2 ERC1 MADCAM1 PELP1 BPTF SORBS3 PNKP SLC34A2 KIF22 GPR3 MED16 ERBB2 PRKAB1 UBAP2L HES1 LIMK2 FAM222B IDUA SOX13 COG2 POGK COCH AAR2 SLC35D2 SLCO3A1 DCTN1 SSBP3 APOBEC2 PRKCZ RALGDS SMYD5 MEPE LUZP2 TRMT2A UPF1 GNAT3 up
## GSE37534_UNTREATED_VS_PIOGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_DN 0.0011547 0.004885 0.4691554 2.078077 0 188 ISG15 USP18 PHACTR4 PTPRA CARHSP1 IFI6 GNAZ OASL IFIT1 TRIM5 RSAD2 EHD4 RBCK1 ATP10A XAF1 MX1 HERC6 LY6E OAS3 BST2 MOK OGFR PML IFI35 RPL13 IFI27 TMEM62 APBA2 LGALS8 TRAFD1 COASY GTPBP2 MX2 EZR SIGIRR CMTR1 IFI44L MID2 TLR3 SECTM1 CEP85 ABCF3 PTN IFIT2 IFIT3 IFI44 MRPL17 RNF114 KDM4A DDX58 STT3A OAS2 PARP12 RTP4 OAS1 PSMB10 RNF19A EIF2AK2 NAPA IFITM1 AFF4 IRF7 CHRNB1 TRIM21 PSME2 HES1 SPSB1 CYB5R3 STOML1 TRIM25 STK19 HK2 TDRD7 IL15RA UBE2L6 ZMAT5 CFLAR HERC5 TRIB2 SNRPD2 FANCF HAX1 APOL2 up
## GSE27786_LIN_NEG_VS_NKCELL_UP 0.0011601 0.004885 0.4709993 2.073292 0 180 MYBPC1 SRRM1 NOB1 SLC7A6 KIAA0895 CLRN3 DDX19A CEP72 USP54 IPO4 RIMKLA MORC2 LRP8 FASTKD5 NUDT12 MLLT1 ATP1A2 CLPX PES1 SUCLG1 SRRT MRPL48 PSMB2 CLNS1A ME3 TIPIN CDH7 ESRRG ZNF205 HRAS ZDHHC13 EIF3L EIF2B5 MIER2 MGME1 HADH TIMM9 GPSM2 YRDC SALL3 RPRD1B NUP93 ODF3B FARSA DAP3 BDH1 GSDMC PITHD1 ARHGAP21 TBRG1 PDXP NOP56 WNT10B SLC30A10 SLC6A13 SORBS3 PPP5C ZNF771 FBXL7 TXN2 SAT2 LCMT2 TIMM8B LRRC42 LDB1 EIF3G FOXRED2 SPSB1 FAM222A ANGPTL4 RCOR3 RRP15 CCDC34 TPM2 NENF ZC3H14 CCNF DTX4 MGMT PCNT LRRC28 BACE2 FRRS1 up
## GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_3H_DN 0.0011601 0.004885 0.4698707 2.073213 0 184 MFHAS1 SLC9A1 DDI2 SLC4A2 NOB1 STARD10 ASL TRIP4 PLCB3 WWP2 NAPEPLD CYB5A ANXA4 CCNL2 CYP4F12 MAPK3 PML GOLM1 TSR3 SUCLG1 PARD6B AP3D1 PRDX5 COASY MROH1 PLCG1 AKIRIN1 SRI TNFRSF25 TNIP2 PKD1 MTMR12 JTB IL4R RNF181 KIF3A CHST12 BCL2L15 SBNO2 SH2B1 KHNYN ARPC1A PFKFB3 CCDC88C CERS4 IRF2BPL RNF11 HDAC4 APLP2 NGRN DDR1 NCMAP SORBS3 RHOC TSPAN13 ALDOC ELOVL6 PJA1 APPL2 SNHG8 FAM217A UIMC1 LCN12 MAPK11 IFT43 PRDM10 TCP11L2 SSBP4 DNAJB2 AMDHD2 ACADS SARS2 PYGB RNH1 IGFBP4 IST1 CREG2 ATRNL1 CHMP5 RPS7 SYS1 FAM91A1 KDELR3 RBMS2 SIRT7 up
## GSE21546_ELK1_KO_VS_SAP1A_KO_AND_ELK1_KO_ANTI_CD3_STIM_DP_THYMOCYTES_UP 0.0011601 0.004885 0.4706797 2.071886 0 180 RERE KIAA0319L SLC12A2 FAM118B TP53BP1 B3GALT6 WRAP73 WDR24 FZR1 NUMA1 POLD3 MLST8 DRD1 METTL3 AVL9 DLG3 ANKS3 WDR60 TMEM63A FGFBP3 TUB MAPK12 LURAP1L TFDP1 TMEM67 MUL1 HOXB4 DFFA NELFCD ZMYND8 GRHL2 GLRA3 ZYG11B TXLNG PRR14 ZSCAN21 TRIM45 MUS81 FEN1 C3orf33 ZSWIM3 SNTB1 NUP93 SZT2 FARSA SNX12 RTP4 PRR15L ARFGAP2 SCAI ARMC6 NUP88 ZBTB8OS MEIS2 RPP25L HEXIM1 AACS TRRAP ERBB3 NRF1 RNASEH1 ZC3H4 UVSSA POT1 DESI2 SLC35D2 HSDL1 MTMR3 GORASP1 CHD6 SLC39A9 TAZ WDR89 SIPA1L1 SCYL3 TTC30B NETO2 PBLD UBR5 TMEM205 LRRC28 INCENP VWA3A EVC2 FBXO38 TAB1 ZNF414 up
## GSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_DN 0.0011614 0.004885 0.4690639 2.071465 0 186 ISG15 USP18 IFI6 OASL IFIT1 TRIM5 RSAD2 EHD4 RBCK1 XAF1 MX1 RNF25 HERC6 ANKFY1 LY6E SLC37A1 OAS3 BST2 GTPBP1 SPATA6 DDX60 PML BTBD2 IFI35 SOBP TMEM62 TRAFD1 LGALS3BP PSMA5 GTPBP2 MX2 TMEM126B RNF31 CMTR1 PSMD11 IFI44L TRIM62 MAD2L1BP BRD7 SPATS2L TRMT5 IFIT2 IFIT3 IFI44 GSTK1 MKRN1 DDX58 OAS2 PARP12 RTP4 NR1H2 OAS1 CCDC85B N4BP1 EIF2AK2 NFYA NAPA IFITM1 TRIM22 MKLN1 IRF7 TRIM21 PSME2 TAF1D ADAR SAMD9 IFIT5 CALCOCO2 ECE1 DRAP1 TDRD7 ZCCHC2 CEACAM1 UBE2L6 HERC5 DAG1 PRRG4 USP25 ATF4 IFIH1 MID1IP1 CHMP5 GSDMD CD2AP UBC up
fgsea_plot(fgsea_res$res_msg, pathways_title='All signatures', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0012048 0.0098351 0.7340737 3.010364 0 105 PRSS33 ZG16B PRSS22 C16orf91 JMJD8 TRAF7 SOX8 RAB11FIP3 NME3 PAQR4 SNRNP25 METRN TBL3 HS3ST6 POLR3K WDR24 C1QTNF8 TELO2 SRRM2 FLYWCH2 RHBDF1 PRSS27 AXIN1 MRPS34 WDR90 CCDC78 NTHL1 GFER RPUSD1 UBE2I IFT140 KREMEN2 ZNF598 NPRL3 MPG STUB1 CAPN15 DECR2 TNFRSF12A SSTR5 TSR3 PDIA2 EME2 LUC7L HAGH TSC2 NDUFB10 PIGQ NUBP2 LMF1 RHOT2 MAPK8IP3 KCTD5 CLDN9 CHTF18 NME4 THOC6 WFIKKN1 SLC9A3R2 CLDN6 PKD1 GNPTG ZNF205 HAGHL RAB40C MRPL28 RPS2 CLCN7 ZNF213 FAHD1 RGS11 RHBDL1 IGFALS up
## chr1p36 0.0010549 0.0098351 0.6120852 2.873955 0 395 SNORA59A DHRS3 GALE RERE FBXO42 VPS13D SSU72 RNF207 SPEN KLHDC7A TRNP1 RNU6ATAC18P CEP104 UBR4 ISG15 NR0B2 DNAJC16 DNAJC11 SLC9A1 NOC2L ARHGEF16 ATAD3B IL22RA1 UBE4B ATAD3A NPHP4 PEX10 DVL1 ATP13A2 MRPL20 ATAD3C AURKAIP1 C1orf174 DDI2 RER1 CASZ1 SMIM1 AKR7A2 SRRM1 MFN2 B3GALT6 AKR7A3 PER3 PUSL1 PLEKHN1 CDK11B EIF4G3 WRAP73 PHF13 PANK4 KAZN KIF1B MTOR UBE2J2 NBPF3 FBXO44 VWA1 DHDDS NADK LYPLA2 GPN2 CROCCP3 ZBTB48 SLC25A33 PGAM1P11 ZBTB17 LRRC47 MRTO4 TMEM201 TMEM222 MTFR1L ICMT TMCO4 RCC2 ARHGEF10L PRDM16 EXOSC10 CDK11A CCNL2 RN7SL574P TPRG1L SDF4 RNF223 CLCNKB AKR7L MAP3K6 C1orf159 HES5 NIPAL3 FBXO2 MIR34A HES4 ARHGEF19 SDHB MMP23A RHCE TARDBP STPG1 TMEM51-AS1 EMC1 KIAA2013 MIR429 PINK1-AS MIIP LDLRAP1 RNU6-1265P CD164L2 PEX14 LINC00337 CLSTN1 PAFAH2 MYOM3 TP73-AS1 MIB2 EPHA2 MORN1 GRHL3 LINC00115 SZRD1 AGRN LINC00339 ARID1A UBXN10 GPR157 NOL9 OTUD3 ENO1 CROCCP2 CNKSR1 MST1P2 UBIAD1 SKI RPS6KA1 ASAP3 FAM87B PARK7 MUL1 TNFRSF25 DFFA PDIK1L NUDC ESPNP TMEM82 CEP85 KLHL17 DDOST NPPA CTNNBIP1 AGTRAP KDM1A SCNN1D MAD2L2 PRDM2 RPL22 ACAP3 WDTC1 MEGF6 ALDH4A1 CALML6 PLEKHG5 MT1XP1 CLCNKA FAM131C IFNLR1 TBCAP2 THAP3 TP73 HMGCL FUCA1 MTND2P28 PLEKHM2 MIR200A MXRA8 TTLL10-AS1 CLCN6 TCEA3 OSTCP2 NBPF1 PINK1 NMNAT1 PITHD1 GNB1 SLC35E2B ANKRD65 NBPF2P CAMK2N1 CROCC VAMP3 MAN1C1 SAMD11 NCMAP RN7SKP269 EPHB2 TMEM51 TMEM52 MMEL1 RPL11 PAQR7 RNU1-3 DRAXIN TMEM88B USP48 UBXN11 GPR3 up
## chr16p13 0.0010917 0.0098351 0.6248261 2.845684 0 272 PRSS33 PDXDC1 PRSS41 ZG16B PRSS22 ADCY9 C16orf91 GLYR1 GSPT1 JMJD8 DNAJA3 UBN1 HMOX2 CARHSP1 TRAF7 PGP SOX8 RAB11FIP3 NME3 PAQR4 E4F1 SNRNP25 MPV17L METRN TBL3 HS3ST6 POLR3K WDR24 RNPS1 C1QTNF8 TELO2 PDPK1 SRRM2 FLYWCH2 RHBDF1 CLEC16A PRSS27 AXIN1 MLST8 MRPS34 ZC3H7A NOMO1 WDR90 CCDC78 NTHL1 GFER PPL RPUSD1 ZNF174 NMRAL1 UBE2I PMM2 CLUAP1 IFT140 KREMEN2 ZNF598 NPRL3 MPG CCDC154 SMIM22 COX6CP1 C16orf90 MGRN1 MIR3180-4 NPIPP1 STUB1 CAPN15 ECI1 ANKS3 DECR2 NPIPA3 CREBBP TNFRSF12A SLX4 SSTR5 NAA60 BRICD5 RRN3 TSR3 PDIA2 EME2 NTN3 METTL22 LUC7L HAGH TBC1D24 MTRNR2L4 TSC2 NDUFB10 PIGQ NUBP2 ZNF597 LMF1 RHOT2 MAPK8IP3 KCTD5 GLIS2 USP7 CLDN9 ABAT CHTF18 NME4 OR1F1 ALG1 PKD1P6 THOC6 WFIKKN1 SLC9A3R2 CLDN6 NUDT16L1 ZSCAN32 PKD1 RSL1D1 GNPTG ZNF205 HAGHL MIR4718 DNASE1L2 RAB40C ABCC1 ZNF263 TMEM186 MRPL28 C16orf72 ERVK13-1 SNHG9 RPS2 ZNF500 SNORD60 RMI2 NPIPA1 DNASE1 CLCN7 ZNF213 GRIN2A FAHD1 RGS11 RHBDL1 IGFALS IL9RP3 NOMO3 MIR5587 FBXL16 PARN WASH4P MIR1972-1 MIR3180-1 TEKT5 FOPNL up
## COLDREN_GEFITINIB_RESISTANCE_DN 0.0011429 0.0098351 0.6341447 2.802562 0 206 TMC5 ADAP1 PRSS22 KCNMB4 SLC1A1 RASEF SLC35A3 EPS8L1 CYP2J2 STARD10 MARVELD3 KIAA1522 MBOAT1 SPINK2 SYTL5 EXPH5 TJP2 REPS2 MYO6 WLS LIMA1 TMEM30B TTC22 PPL LIPH TACSTD2 GUK1 SMAGP STAP2 SMIM22 ST14 TMEM54 GNAS CST6 AGR2 LRG1 ELF3 LSR GALNT3 LNX1 STK39 FRMD4B CDH1 BIK EPN3 GRHL3 ADK C6orf132 SCAMP2 B3GNT3 TBC1D8B LAD1 MROH1 CNKSR1 CDS1 CLDN9 RAB25 C1orf21 MYO1D PRSS8 CGN EPHA1 DOK7 SVIL EPS8L2 OVOL1 RIPK4 HS3ST1 GRHL2 MACC1 TJP3 ESRP2 C1orf116 ERP27 OVOL2 SH3BGRL2 SH3YL1 SPINT1 PLEKHA7 MYH14 WEE1 MPP7 SPTLC3 EHF FXYD3 RNF114 AP1M2 HMGCL MST1R RBM47 SLC44A3 GPR160 TSPAN1 IRF6 KLC3 CDH3 GRHL1 FAM110A KIAA1211L RHOD RAB11FIP4 KRT19 PRR15L SMIM5 MAL2 MAPK13 DDR1 ELMO3 TMEM45B AIG1 KANSL1-AS1 CAPN8 LMO7 ENPP5 PITPNM3 ERBB3 VAMP8 FAM171B MFSD6 up
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0010799 0.0098351 0.6001352 2.764794 0 308 RNF207 SUN1 SLC52A3 ATAD3B ATAD3A EIF3B MTOR RNPS1 FBXO44 SRRM2 KCTD13 FNBP4 SMARCA4 TMEM201 RCC1 CC2D1B GFER TBC1D22B FBXL19 MARK2 IL17C FBXL18 ZNF598 TARDBP ANKRD54 SNHG3 CAPN15 MIIP HHLA3 KAT8 INTS1 EVI5L REXO1 TMEM63A RTKN LSM14B SETD1A ZC3H7B MDN1 POLM NSUN4 PTBP1 SRCAP CSNK1G2 TRMU ZMYND19 GAS5 ATXN2L HIP1R HPCA TICAM1 XPO5 AGRN MAPK8IP3 PHKG2 TMEM259 CMTR1 EYA3 CDC42EP1 STK11 SRRT PPP1R12C TEAD3 CCAR2 ZNF646 ABCF3 TNPO3 PPP6R2 CPSF7 PIP5K1A COPS7B LRCH4 SMG5 L3MBTL2 SNAPC4 HDAC7 SF1 SCAF1 RHBG ZNF473 CACTIN NPIPB3 HSF4 TRABD PICK1 TNPO2 MICALL1 GBA2 LTB4R ZNF316 CTNND1 DAGLB TMEM86B EPN1 RPL18 MAP2K2 ZNF133 AP5Z1 SBNO2 LEMD2 ACIN1 KDM4A ZNF692 GIGYF1 AMPD2 PHF5A SZT2 SGSM3 APBA1 GATAD2A KLF16 ILF3 KCNK5 BRD1 SFSWAP DOT1L FANCA LMNA RANGAP1 PDXP RBM33 ARMC6 GRIPAP1 C7orf26 ZBTB7B CSNK1E MAPRE3 RABGAP1 PPARD SMG7 DHX33 ARHGEF2 U2AF2 PPM1G PUS1 PPRC1 CLASRP TAF1C TRRAP LPAR2 GPC2 TTC17 UBAP2L SH3BP5L ARHGEF11 LIMK2 MYPOP SUGP2 KHSRP ZNF202 R3HDM4 MYO9B ZNF638 GGA1 NSUN5P1 ZMIZ2 HAUS8 MAPK11 GLP1R ABCA7 SPON2 SPPL2B FBRSL1 AP5S1 URB2 KMT2D NUP214 CAMK2B TCOF1 LARP1 TPM2 RASSF7 POLR2F SLC12A9 DAZAP1 USP21 SCUBE1 SAFB2 SLC39A3 THOC2 B4GALT1 MOGS UQCC2 NEURL4 up
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 0.0011001 0.0098351 0.5976224 2.706522 0 256 GALE TMC5 BAIAP2L1 AURKAIP1 GIPC1 RASEF SLC35A3 TTLL12 MYO10 STARD10 GSS VSIG2 PACSIN2 MYO6 CHMP1A SMARCA4 TMEM30B FDFT1 TTC22 SLC2A10 ICA1 RNF128 HDAC1 PREP TACSTD2 BTBD3 TRAK1 CIB1 GMDS TSPAN8 IL20RA ST14 MRPS18A AGR2 SLC22A23 VSIG10 ELF3 PLS1 GALNT3 TMEM63A DDAH1 CHMP4C ZGPAT AGR3 NADSYN1 IFI27 FUT2 HIP1R SCAMP2 TOX3 C1GALT1 RRBP1 GNA11 MROH1 ABCD3 VPS37B TMEM259 RAB25 GFPT1 KDELR2 STYK1 RPS6KA1 EPS8L2 C4orf19 MRPL14 MVP TNIP2 ZMYND8 ARRDC1 TSTA3 TJP3 ESRP2 C1orf116 JTB DOK4 OVOL2 SH3BGRL2 NET1 SYTL2 EIF2B5 EPCAM FRK GRTP1 FNIP2 MANSC1 EHF FXYD3 RABEP2 SART1 MGLL LRRC8B CC2D1A ABHD17C GSTK1 CLPTM1L PLAC8 GPR160 SRPK1 CTBP2 SGSM3 SGPP2 TRAF4 CAMK2N1 RRP7A RNF126 PLEKHJ1 MKNK2 MLPH PSMB10 MARVELD2 MED16 MT-ATP6 TNFSF10 RABL6 AACS ERBB3 EPHB4 POP7 CANT1 MRPL41 OXLD1 ESRP1 CCDC107 AKAP13 DOHH TUBA4A TOMM40 LZIC CRB3 QSOX1 FA2H ATP8B1 TMEM125 C3orf52 SLC35D2 DNAJB2 EIF4G1 HDLBP RALA RALY NOSIP ABCC3 MRPL52 BPHL up
## CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 0.0010526 0.0098351 0.5674392 2.667720 0 406 PDXDC1 TFF1 KIAA0319L SUN1 USP18 SLC52A3 ZG16B ENTPD2 KIAA0556 DEGS2 GSPT1 TTC39A JMJD8 DAAM1 AAGAB DDI2 CASZ1 IQCE NME3 RASEF PAQR4 ANK3 EPS8L1 TMPRSS2 FAAH STARD10 MARVELD3 PRR15 KIAA1522 EXPH5 RHBDF1 CACNA1D MYO6 TMEM30B SHANK2 CYB5A ICA1 SLC29A2 COG7 SLC37A1 SH2D3A FAM214A TRIB3 TMEM184A ST14 CNNM4 NR2F6 FREM2 MYO5B GGCT DLG3 AGR2 SLC25A29 ELF3 LSR LNX1 MYO5C ZXDC MSX2 CHMP4C CDH1 TRPM4 CYB561 ARHGEF5 BIK EPN3 PPP2R5A HIP1R TLE3 C6orf132 SERINC2 SCAMP2 ISG20L2 TOX3 GPR157 LAD1 CDS1 SIGIRR RAB25 ARFIP2 MYO1D PRSS8 HID1 CGN SEPHS2 ABAT EPHA1 TFF3 DOK7 FOXA1 HOOK1 PRLR PGAP2 TMED3 EPHB3 C4orf19 ZHX2 IGFBP2 SPATA2L RUSC1 OCLN OVOL1 MAP7 GRHL2 MACC1 ARRDC1 TJP3 LMTK3 ESRP2 KIAA1324 JTB WFS1 OVOL2 PPP1R16A SH3YL1 SPINT1 TM7SF2 HOOK2 MYH14 RAB40C TMPRSS13 EPCAM ALDH4A1 INPP5J MPP7 BCR SLC9A3R1 PLEKHA6 EHF FXYD3 RABEP2 AZGP1 GPD1L CBLC AP1M2 TPD52L1 TMEM134 ZKSCAN1 RBM47 GPR160 GGT6 PKP3 PER2 TRIM3 RSPH1 TNKS1BP1 RMND5B TSPAN1 IRF6 UBQLN4 CDH3 PROM2 SFI1 DBP GRHL1 FAM110A CERS6 KIAA1211L ZNF74 TRAF4 RAB11FIP4 KRT19 PRR15L RHPN1 MAL2 ARFGAP2 CAMSAP3 CAMK2N1 TADA2B DDR1 ELMO3 CKMT1B TMEM45B ZBTB7B MMEL1 MKNK2 MLPH CAPN8 P4HTM TTC9 TSPAN13 NPDC1 MRFAP1L1 PATZ1 MARVELD2 RAB27B PPM1H TSTD1 ERBB2 MUCL1 ENPP5 ERBB3 FAM102A CADPS2 MRPL41 LIMK2 NEBL ESRP1 SOX13 ZBTB42 TBC1D30 FA2H TMEM125 FEM1B TMEM183A PPCS ROGDI ZNF467 EPB41L4A ARHGAP8 MB SSH3 RAB17 TMEM191A RALGPS1 CSAD ZNF385A PCDH1 MPZL3 RNF103 EFNA4 SELENBP1 DHRS13 C1orf43 PCK2 MGMT SCYL3 FANCF ABCC11 SPINT2 DNAJC1 up
## chr16q22 0.0011710 0.0098351 0.6191996 2.622891 0 132 ACD CYB5B E2F4 DYNC1LI2 EDC4 CES3 NOB1 CHST4 PARD6A SLC7A6 MARVELD3 WWP2 C16orf70 NFAT5 CES2 DDX19A SMPD3 NIP7 NUTF2 RANBP10 VPS4A SF3B3 COG4 EXOSC6 CENPT SLC7A6OS LCAT SLC9A5 CDH1 PSKH1 HAS3 CMTM4 NAE1 ATP6V0D1 DDX19B SNTB2 FTLP14 TRADD PDXDC2P ENKD1 PRMT7 TERF2 HSD11B2 KIAA0895L DHX38 ESRP2 HYDIN FBXL8 THAP11 PDF RN7SL279P HSF4 VAC14 MIR1972-2 ZFHX3 SLC12A4 ZDHHC1 CTCF PDP2 CDH3 GFOD2 FHOD1 CBFB TMEM208 ELMO3 PSMB10 RNU6-1262P CES4A ATXN1L TANGO6 B3GNT9 KCTD19 CMTR2 up
## chr7p22 0.0012469 0.0098351 0.6449290 2.561873 0 85 SUN1 ADAP1 GET4 ZNF12 ZDHHC4 IQCE EIF3B PMS2CL GPER1 MAD1L1 PMS2 FBXL18 TMEM184A EIF2AK1 TNRC18 WIPI2 USP42 INTS1 AIMP2 C1GALT1 PSMG3 KDELR2 RBAK RNF216P1 FAM220A RNF216 RAC1 SNX8 BRAT1 CARD11 CHST12 ZNF316 DAGLB AP5Z1 COX19 MIR589 SLC29A4 ZNF890P C7orf50 CCZ1B PRKAR1B MICALL2 CYTH3 C7orf26 FOXK1 UNC93B2 FAM20C AMZ1 OR7E136P ANKRD61 NUDT1 GPR146 ALG1L5P PDGFA up
## WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP 0.0011765 0.0098351 0.5920033 2.506835 0 134 SH3RF1 RASEF SLC35A3 MYO10 MYO6 ARHGAP12 TMEM30B FDFT1 RNF128 CYP51A1 GMDS TSPAN8 VSIG10 PLS1 GALNT3 DDAH1 STK39 CHMP4C AGR3 GOLPH3 EDEM3 TOX3 ABCD3 GFPT1 CMPK1 KDELR2 CASK SYT13 CA2 MAP7 ASPHD2 TSTA3 BRI3BP DOK4 SH3BGRL2 NET1 CLDN23 NME7 SYTL2 EPCAM FRK GGT1 GRTP1 FNIP2 TMED4 PHLDA2 SLC39A14 LRRC8B ABHD17C PLAC8 GPR160 CTBP2 ABHD2 SGSM3 GDA ETNK1 HINT3 MAL2 PERP SH2D4A LYZ SLC39A11 SAR1B ELOVL6 ERBB3 EPHB4 ESRP1 GPATCH4 QSOX1 ATP8B1 C3orf52 SLC35D2 RALA NUDT15 ABCC3 OCIAD2 KCNK1 BZW2 PBLD GALNT7 ETFB MUC1 CD24 GALNT4 FZD5 KIAA1841 F11R up
## ETF_Q6 0.0012121 0.0098351 0.6013338 2.474642 0 112 RERE UBR4 SRRM1 MFN2 PHF13 FAF1 MTOR YTHDF2 MCU ZBTB17 MRTO4 FAM76A TMEM222 PRDM16 ZNF362 POMGNT1 KPNA6 ST6GALNAC5 SLC41A1 ZNF496 LRP8 EMC1 KIAA2013 SPATA6 SKIDA1 CLSTN1 ARID1A LAD1 C1orf21 CMPK1 EFNA3 RUSC1 ZFYVE9 MAST2 CTNNBIP1 KCND3 KDM1A CAMK1D NFYC MARCKSL1 CELSR2 RASAL2 DAP3 AGO3 ARTN PITHD1 GNB1 VAMP3 MAN1C1 HPCAL4 ASH1L YY1AP1 USP48 ATXN7L2 WDR78 NFIA TRIM33 RNF220 SOX13 AGO1 XPR1 SSBP3 RPRD2 USP21 C1orf43 CAMK2G SCYL3 up
## chr1p35 0.0012225 0.0098351 0.6019850 2.444269 0 99 SRSF4 OPRD1 PHACTR4 TRNAU1AP IFI6 MECR TMEM234 SESN2 BSDC1 YTHDF2 KIAA1522 SNORA73B TXLNA EPB41 PEF1 FAM76A SNHG12 RCC1 ZNF362 HDAC1 PTPRU FNDC5 AHDC1 KPNA6 TMEM54 EIF3I PUM1 SNHG3 HPCA SERINC2 EYA3 ZBTB8A SCARNA1 IQCC SYNC TRIM62 AK2 PPP1R8 TMEM200B TAF12 STX12 S100PBP MARCKSL1 SPOCD1 KHDRBS1 ZSCAN20 SNRNP40 TSSK3 SNORA44 MIR5585 ZBTB8OS RBBP4 HMGB4 RN7SL559P DNAJC8 ZCCHC17 MED18 ZBTB8B HSPD1P14 up
## REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION 0.0012531 0.0098351 0.6146011 2.442340 0 86 RPL13 RPLP0 RPS21 RPS5 RPL24 EEF1A2 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A EEF2 EEF1D RPS26 RPS4X RPS3A RPS7 RPL36AL EEF1B2 RPL5 RPL27 RPL23A RPL23 RPL30 RPL14 RPS16 RPL41 up
## KEGG_RIBOSOME 0.0012690 0.0098351 0.6162810 2.423077 0 81 RPL13 RPLP0 RPS21 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPS4X RPS3A RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 RPL30 RPL14 RPS16 RPL41 up
## REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY 0.0012300 0.0098351 0.5968259 2.410954 0 94 TRIB3 RPL13 RPLP0 RPS21 RPS5 RPL24 RPLP1 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 DDIT3 RPS15 RPL11 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 ASNS RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPS4X ATF4 RPS3A RPS7 RPL36AL RPL5 RPL27 EIF2AK4 RPL23A RPL23 RPL30 RPL14 RPS16 RPL41 up
## NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON 0.0011765 0.0098351 0.5691117 2.409901 0 134 NTSR1 DIDO1 TAF4 MRGBP HELZ2 YTHDF1 OSBPL2 CABLES2 PRPF6 ADRM1 UCKL1 SPATA2 TCFL5 GID8 PMEPA1 ZNF512B GNAS SS18L1 SLC2A4RG OGFR LSM14B VAPB ARFGAP1 ZFP64 PCK1 ZGPAT RPS21 PARD6B SDC4 TFAP2C MTG2 TMEM189 MATN4 RBBP8NL ARFGEF2 DNAJC5 EEF1A2 COL20A1 ARFRP1 RTEL1 NELFCD ZMYND8 LAMA5 SLCO4A1 SEMG1 CDH4 SAMD10 ATP9A KCNQ2 TOMM34 RNF114 PSMA7 GMEB2 TPD52L2 RAB22A PI3 SALL4 CHRNA4 NPEPL1 TSHZ2 SLC9A8 ABHD16B up
## GSE6269_FLU_VS_E_COLI_INF_PBMC_UP 0.0011481 0.0098351 0.5590723 2.409616 0 153 ISG15 USP18 GLYR1 RNF40 IFI6 SLC4A2 OASL C2CD3 GSE1 RSAD2 KCTD13 XAF1 MX1 HERC6 MARK2 OAS3 CAPN15 DDX60 IFI35 PKM NFATC2IP POLM AP3D1 SZRD1 AGRN OGDH LGALS3BP GTPBP2 MX2 CMTR1 DNAJC4 SREBF2 IFI44L USP10 UBA1 SPATS2L TRABD IFI44 CHST12 VPS39 ACTN4 HECTD3 GAK ACIN1 NPIPA1 PI4KB ARPC1A OAS2 SZT2 PARP12 SUPT6H OAS1 DCAF15 N4BP1 DNM2 ATP13A1 BPTF SMG7 EIF2AK2 SHC1 IFITM1 CXXC1 IRF7 GPATCH8 TRIM21 PDHX ADAR MYO9B STRN4 C16orf58 SART3 NCOA6 EIF4G1 DCTN1 LARP1 PURA PHACTR2 EBAG9 up
## GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 0.0011990 0.0098351 0.5819252 2.407443 0 114 GSPT1 RNPS1 HELZ2 EXOSC10 RPL13 SMG1 RPLP0 RPS21 RPS5 RPL24 RPLP1 SMG5 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A UPF3B RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 SMG7 PARN ETF1 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 MAGOH EIF4G1 CTIF RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 UPF1 RPS4X SMG6 RPS3A RPS7 RPL5 DHX34 RPL27 RPL23A RPL23 RPL30 PPP2R1A RPL14 RPS16 RPL41 up
## GO_RIBOSOME_BIOGENESIS 0.0010965 0.0098351 0.5301479 2.406656 0 259 NOC2L MRPL20 TBL3 NOB1 GNL2 MRTO4 NOM1 EXOSC10 NIP7 BMS1 RPUSD1 ERI1 UTP14A ERI3 PWP2 EIF6 EXOSC6 SBDS NOP2 NOC4L PES1 MYBBP1A FAM207A MDN1 RRN3 TSR3 METTL16 NSUN4 RPLP0 RPS21 ISG20L2 RPP25 NOL9 MTG2 GEMIN4 NOP14 RPUSD2 RPLP0P6 RPS5 RPL24 MRPS2 RRNAD1 WDR55 NGDN XRN2 RSL1D1 NLE1 DDX51 KRI1 DDX31 VCX RRP9 RPL10A NOL6 DHX37 SART1 RPS2 BOP1 RPSA DDX27 ESF1 RPS28 WDR18 TFB2M RRP1 RPL35 NOLC1 DDX49 NSUN3 THUMPD1 ERAL1 DROSHA TSR1 RPS14 RRP7A LAS1L IMP3 TRMT112 RPL3 EBNA1BP2 NOP56 DDX56 RPL12 UTP18 PELP1 NUP88 RPS15 RPL11 GTPBP4 ZNHIT6 AATF URB1 MRPL11 NAT10 NVL RRP1B POP7 RRP8 MRPS11 MALSU1 UTP20 WDR3 RPS8 METTL15 EXOSC5 EXOSC2 HEATR1 NOL10 URB2 DDX54 RRP15 DDX28 RRS1 LYAR GTPBP10 MPHOSPH10 RBFA NAF1 IMP4 RPL38 RPS27 RPS9 RPL35A CUL4B PPAN HEATR3 DDX10 TSC1 MRPS7 RPP38 NSUN5 MPV17L2 UTP6 PIH1D1 RPS7 PAK1IP1 up
## VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_DN 0.0011765 0.0098351 0.5671266 2.400488 0 133 LGALS4 ODAM FAM3D REG4 TMC5 ALDOB TFF2 RER1 SNRNP25 TMPRSS2 GCNT3 LPCAT4 STARD10 GATA4 RHPN2 PTPRN2 VSIG2 CLRN3 CES2 CFTR LIG3 SLC4A4 CYSTM1 SULT1A2 GMDS ARX GOLM1 EPN3 VILL CA13 TFF3 PRSS3 DPP3 BTNL8 CA2 CALML4 IFT57 KIAA1324 REG1A CLDN23 FXYD3 CLDN18 BCL2L15 ENTPD3 HSD17B2 GSDMB GP2 AADAC WNK4 DOT1L NAT1 REEP6 CKMT1B TMEM45B ZBTB7B SENP8 MLPH up
## REACTOME_RRNA_PROCESSING 0.0011338 0.0098351 0.5482568 2.399245 0 184 TBL3 NOB1 EXOSC10 NIP7 BMS1 ERI1 UTP14A PWP2 EXOSC6 NOP2 NOC4L PES1 RPL13 TSR3 NSUN4 RPLP0 RPS21 ISG20L2 RPP25 NOL9 NOP14 RPS5 RPL24 XRN2 RPLP1 RRP9 RPL10A RPL22 NOL6 RPL39 RPS3 RPL29 DHX37 RPL18A FAU RPS2 BOP1 RPL18 RPSA RPL36 RPS12 RPS28 WDR18 RPL13A RRP1 RPL35 DDX49 THUMPD1 TSR1 RPS14 RPS13 RRP7A RPS11 LAS1L IMP3 TRMT112 RPL32 RPL3 EBNA1BP2 NOP56 RPL12 UTP18 RPLP2 PELP1 CSNK1E RPS15 RPL11 NCL NAT10 RPL34 RPS15A RPL9 UTP20 RPS23 WDR3 RPS8 EXOSC5 EXOSC2 HEATR1 RPS29 RPL31 CSNK1D RPS27A UBA52 MPHOSPH10 IMP4 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 RPP38 RPS4X RBM28 RPS3A UTP6 RPS7 RPL36AL up
## HOLLERN_EMT_BREAST_TUMOR_DN 0.0011990 0.0098351 0.5774255 2.388828 0 114 ATP6V1C2 SHROOM3 ARHGEF16 EPS8L1 TMPRSS2 WWC1 STARD10 RHPN2 TMEM30B ILDR1 STAP2 TMEM184A ST14 TMEM54 MYO5B EPB41L4B PTPRF LSR CDH1 HIP1R TFAP2C ELOVL7 KIF21A RAB25 PRSS8 EPHA1 EPS8L2 EFNA3 OCLN OVOL1 MAP7 RIPK4 GRHL2 TJP3 ESRP2 SPINT1 MYH14 TMPRSS13 EPCAM LRBA EHF FXYD3 CBLC AP1M2 PKP3 CELSR2 IRF6 KLC3 CDH3 GRHL1 MAL2 TNK1 DDR1 CKMT1A ELMO3 MARVELD2 PLEKHG6 ERBB3 ESRP1 EVPL SORT1 CRB3 C1orf210 CDCP1 CEACAM1 CCDC120 POF1B SPINT2 KCNK1 CHDH ACOT2 THRSP JUP GRB7 PLEKHH1 CD24 up
## REACTOME_NONSENSE_MEDIATED_DECAY_NMD 0.0012048 0.0098351 0.5796541 2.381225 0 108 GSPT1 RNPS1 RPL13 SMG1 RPLP0 RPS21 RPS5 RPL24 RPLP1 SMG5 RPL10A RPL22 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA RPL36 RPS12 RPS28 RPL13A UPF3B RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 RPLP2 RPS15 RPL11 SMG7 ETF1 RPL34 RPS15A RPL9 RPS23 RPS8 RPS29 MAGOH EIF4G1 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A RPS26 UPF1 RPS4X SMG6 RPS3A RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 RPL30 PPP2R1A RPL14 RPS16 RPL41 up
## chr1p34 0.0011299 0.0098351 0.5404199 2.381115 0 192 KIAA0319L MUTYH THRAP3 INPP5B ZSWIM5 SCMH1 ZMYM4 TRAPPC3 CITED4 GNL2 NCDN TMEM53 C1orf122 ADPRHL2 POMGNT1 STK40 ERI3 ZMYND12 FOXO6 TRIT1 MEAF6 MAP7D1 RIMKLA RHBDL2 OSTCP5 IPP PTPRF RPL5P4 RN7SL503P GPBP1L1 DPH2 ZMPSTE24 COL9A2 ELOVL1 MRPS15 PSMB2 AKIRIN1 GUCA2A GJA9 EIF2B3 MTF1 RLF MAST2 B4GALT2 PIK3R3 RNU6-1237P SNIP1 RNA5SP44 RNU6-584P DNALI1 OSCP1 TEKT2 ZC3H12A MANEAL NFYC HECTD3 SF3A3 IPO13 C1orf216 CCDC24 SLC2A1 PPIE KDM4A YRDC MACF1 MED8 SZT2 TSPAN1 COL8A2 HIVEP3 C1orf109 AGO3 ARTN ZMYM1 EXO5 EBNA1BP2 ERI3-IT1 HPCAL4 RNU6-608P FOXJ3 CTPS1 CLSPN RNF220 EPHA10 TMSB4XP1 PLK3 AGO1 RPS8 AGO4 SNORD46 TMEM125 NASP SLC2A1-AS1 C1orf210 PPCS ZNF684 ZMYM4-AS1 SNORA55 up
## GO_NCRNA_PROCESSING 0.0010707 0.0098351 0.5142387 2.379100 0 325 TYW1 SMAD3 PUSL1 CTU2 TBL3 POLR3K NOB1 MTFMT MRTO4 EXOSC10 BMS1 INTS5 RPUSD1 ERI1 UTP14A ERI3 PUS7 TRIT1 PWP2 METTL3 EXOSC6 SBDS NOP2 NOC4L INTS1 TRPT1 TRMT61A TSEN54 PES1 FAM207A MDN1 TSR3 GTPBP3 METTL16 NSUN4 RPS21 TRMU ISG20L2 RPP25 NOL9 CTU1 GEMIN4 NOP14 INTS4 SEPHS2 RPUSD2 SRRT ADAT1 NSUN2 RRNAD1 WDR55 NGDN XRN2 RSL1D1 TP53RK DDX51 TRMT1 KRI1 DUS3L TRMT11 DUS1L RRP9 TRMT5 RPL10A TARBP1 NOL6 TRMT12 DHX37 SART1 RPS2 BOP1 DDX27 ESF1 RPS28 WDR18 TFB2M RRP1 RPL35 NOLC1 DDX49 NSUN3 THUMPD1 AGO3 DROSHA TSR1 RPS14 RRP7A TRMT6 LAS1L IMP3 TRMT112 EBNA1BP2 DGCR8 NOP56 DDX56 AARS2 UTP18 PELP1 RTCB TRMT44 RPS15 RPL11 PARN ANKRD16 CSTF2 ZBTB8OS ADAT3 GTPBP4 ZNHIT6 URB1 LCMT2 NAT10 PUS1 NVL USB1 RRP1B POP7 RRP8 ADAR MRPS11 UTP20 WDR3 AGO1 RPS8 METTL15 AGO4 METTL1 TRDMT1 EXOSC5 EXOSC2 HEATR1 NOL10 TSEN2 RNF113A RPUSD4 DDX54 RRP15 RRS1 KTI12 LYAR MPHOSPH10 RBFA MOCS3 NAF1 FARS2 IMP4 CDK5RAP1 RPS27 RPS9 AGO2 SEPHS1 RPL35A DDX10 GRSF1 RPP38 CPSF4 DUS2 PUS10 NSUN5 UTP6 INTS7 PIH1D1 RPS7 up
## LIM_MAMMARY_STEM_CELL_DN 0.0010616 0.0098351 0.5041419 2.360851 0 387 GABRP GALE KIAA0319L SLC5A1 ARHGEF16 BAIAP2L1 RER1 CASZ1 SMIM1 GIPC1 SLC35A3 KIF1B TMPRSS2 FAAH STARD10 MARVELD3 KIAA1522 MBOAT1 FADD RHPN2 EPB41 PACSIN3 ZNF334 SUSD4 MPI ILDR1 ICA1 PPL FGF13 LIPH SLC37A1 CIB1 STAP2 ST14 TMEM54 NGEF MYO5B DLG3 ANO9 DECR2 ELF3 ALG8 PTPRF IFI35 LSR MYO5C TIRAP CDH1 GOLM1 BIK TMEM139 HAGH TMEM62 KRT8 LGALS3BP MTUS1 RAB11FIP1 COASY HMGXB4 SIGIRR RAB25 VILL HID1 CGN ADAT1 DHCR7 FOXA1 DBNDD2 VTCN1 AP1G2 PRLR PGAP2 TMED3 SNX8 ACOT8 MVP HOMER2 TLR3 CA2 RMDN3 ARRDC1 PAK1 TJP3 KIAA1324 SPINT1 TM7SF2 MYH14 RPL22 ATP6V0E2 HLCS TMPRSS13 EPCAM FRK LRBA SLC22A18 GRTP1 MANSC1 SLC9A3R1 BARX2 PIGO CBLC CPT2 HDHD3 AP1M2 ATG2A ABHD17C GSTK1 TFAP2A RBM47 DHCR24 CXCL17 ARPC1A SGSM3 TOM1L1 IBTK BDH1 GRHL1 FAM110A WNK4 RAB11FIP4 FAM221A KRT19 COBL CAMSAP3 NAT1 MAPK13 TPCN1 ELMO3 REEP6 ZSCAN20 SLC16A5 RFX1 GCC2 ALDH5A1 MLPH RABGAP1 SLC39A11 CTPS2 PPM1H PXMP2 ERBB2 CORO2A RAD51D ERBB3 OXLD1 ZDHHC12 EVPL OS9 PDZK1IP1 CLDN8 ZSWIM4 CRB3 NCOA2 TMEM125 IFT43 C1orf210 SLC35D2 ZFAND2B TCIRG1 MTA3 CGNL1 MB SSH3 CCT6B ANKRA2 SNRNP35 RALGPS1 RREB1 PRKCZ NUDT1 RASSF7 WFDC2 CEACAM1 SLC39A9 up
## GCM_TPT1 0.0013298 0.0098351 0.6284799 2.356482 0 59 RPLP0 RPS21 RPLP1 RPL10A RPS3 RPL29 RPS2 RPL18 RPSA RPS28 RPL13A RPL35 RPS14 RPS11 RPL32 RPL3 RPLP2 RPL11 NCL RPL34 RPL9 RPS23 RPS8 RPS29 RPL31 RPS27A UBA52 RPL38 RPL4 RPL27A RPL28 RPS9 RPL19 RPL35A EEF2 RPS3A RPS7 RPL27 RPL23A RPL23 CLEC18C RPL14 PPIA RPS16 up
## LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 0.0010091 0.0098351 0.4874588 2.355495 0 716 GALE RERE FBXO42 VPS13D SSU72 SPEN CEP104 KIAA0319L UBR4 SRSF4 ANKRD13C DNAJC16 DNAJC11 SLC9A1 THRAP3 ZSWIM5 UBE4B ACAD8 PHACTR4 ATP13A2 TTC39A SCMH1 ZMYM4 DDI2 DYNC2H1 RER1 TRNAU1AP AKR7A2 SRRM1 MFN2 COA4 B3GALT6 AKR7A3 PER3 TRAPPC3 C2CD3 TMEM234 EIF4G3 WRAP73 PHF13 FAF1 PANK4 KIF1B SESN2 MTOR MSANTD2 UBE2J2 BSDC1 NBPF3 DHDDS YTHDF2 KIAA1522 NADK ARHGAP32 BAD LYPLA2 NUMA1 RNF169 POLD3 GPN2 NCDN ZBTB48 TXLNA ZBTB17 EPB41 LRRC47 RSF1 PEF1 FAM76A TMEM201 CDON TMEM222 MTFR1L ICMT ARHGEF10L EXOSC10 CCNL2 C1orf122 ZNF362 ADPRHL2 POMGNT1 SC5D TPRG1L SDF4 DGAT2 STK40 FNDC5 ERI3 DCUN1D5 ZMYND12 AHDC1 TRAK1 MICU1 KPNA6 LRRC41 MEAF6 MAP7D1 PPME1 SDHB CREBZF PUM1 RHCE EMC1 KIAA2013 SPATA6 NARS2 MIIP LDLRAP1 PEX14 IPP ALG8 PTPRF CLSTN1 PAFAH2 EFCAB14 TP73-AS1 MIB2 FGFBP3 NSUN4 ARHGAP1 FOXRED1 LETM1 GPBP1L1 ZMPSTE24 SZRD1 LEPR CLPB ARID1A COL9A2 NOL9 LRTOMT CROCCP2 NOP14 TMEM126B ELOVL1 UBIAD1 CMPK1 ZBTB8A INTS4 MRPL48 RPS6KA1 LAMTOR1 ASAP3 SYNC PARK7 AKIRIN1 MUL1 DLG5 TNFRSF25 CLNS1A TRIM62 ME3 MTF1 AK2 NUDC RLF CEP85 UBE4A DDOST MAST2 CTNNBIP1 PAK1 PPP1R8 ZYG11B CMTM8 NELFA PIK3R3 CTBP1 MAD2L2 GLB1L2 PRDM2 GRPEL1 WDTC1 SNIP1 PCF11 RPS3 DNALI1 MANEAL TAF12 STX12 HECTD3 S100PBP RNF4 CPLX1 SF3A3 PRPF38A THAP3 IPO13 C1orf216 MARCKSL1 GAK HMGCL PPIE KDM4A PLEKHM2 CPEB3 MACF1 STT3A CTBP2 MED8 FAM193A SZT2 CLCN6 MAEA HIVEP3 PINK1 AGO3 RNF11 KHDRBS1 NMNAT1 PITHD1 CTDSPL TXNDC12 GNB1 TBRG1 TACC3 CCDC85B APLP2 BLOC1S4 PAAF1 ZMYM1 HK1 GLB1L3 VAMP3 RPL32 EXO5 EBNA1BP2 MAN1C1 PIGG NEAT1 MRFAP1 SNRNP40 TMEM51 DPF2 HPCAL4 TMEM175 CC2D2A MFSD10 GOLGA4 PAQR7 BTF3L4 ZBTB8OS MRFAP1L1 ATPAF1 ASRGL1 FOXJ3 SIK3 USP48 DNAJC6 WDR78 PCGF3 TIMM8B LRRC42 INPP5A OSBPL9 NFIA TSKU RBBP4 TAF1D PIGV RNF220 LCOR DHX15 SPSB1 EPHA10 NDUFC2 DNAJC8 ZCCHC17 ZNF202 SNX19 UVSSA MED18 LZIC CHD5 AGO4 CAMTA1 ACOT7 ZBTB8B IFIT5 ATXN7 NASP SCP2 SLBP PRDM10 PPCS ZNF684 BEND5 RPUSD4 THYN1 ECE1 TMEM59 KRBOX1 VGLL4 BMPR1A PRKCZ BUD13 up
## REACTOME_EUKARYOTIC_TRANSLATION_INITIATION 0.0012121 0.0098351 0.5711223 2.350314 0 112 EIF3B EIF3I RPL13 RPLP0 RPS21 RPS5 RPL24 EIF2B3 RPLP1 RPL10A RPL22 EIF3L EIF2B5 RPL39 RPS3 RPL29 RPL18A FAU RPS2 RPL18 RPSA EIF3D RPL36 RPS12 RPS28 RPL13A EIF3C RPL35 RPS14 RPS13 RPS11 RPL32 RPL3 RPL12 EIF2B2 RPLP2 RPS15 RPL11 RPL34 EIF3G RPS15A RPL9 RPS23 RPS8 RPS29 EIF4G1 RPL31 RPS27A UBA52 RPS20 RPL38 RPL4 RPS27 RPL27A RPL37A RPL28 RPS9 RPL19 RPL35A EIF3M RPS26 RPS4X RPS3A EIF5B EIF4EBP1 RPS7 RPL36AL RPL5 RPL27 RPL23A RPL23 RPL30 EIF3J RPL14 RPS16 RPL41 up
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0011299 0.0098351 0.5347527 2.348637 0 187 NOC2L UBN1 AURKAIP1 SRRM1 AMBRA1 E4F1 TAF4 TBL3 LPCAT4 OSBPL2 ZBTB17 PEF1 ADRM1 POLD2 DNAJC17 LRRC41 SLC7A5 ZNF512B SLC2A4RG CDC37 CFDP1 NAA60 TSR3 NADSYN1 PTBP1 SF3A2 SLC25A22 SIGIRR TMEM259 MRPS2 THOC6 XAB2 ABCF3 PPP6R2 VPS51 TSTA3 HRAS COPS7B TAF10 AAMP CDCA4 SART1 MARCKSL1 AP5Z1 UBE2M ANAPC2 RPL36 WDR18 PRCC SSRP1 TRAPPC2 GATAD2A TRIM28 STK25 DCAF15 TACC3 CCDC85B BRMS1 EXOC7 HSPA9 NONO RPLP2 HMG20B PSMB10 ATP13A1 MFSD10 RPL11 C9orf16 U2AF2 PRPF19 GADD45GIP1 TAF1C FUS SMARCD2 POLR2E PDLIM2 VPS9D1 FOXK2 PFDN2 NELFB TNFRSF14 THAP7 SH3GLB2 ATP1A1 DRAP1 RRS1 DGKZ PDAP1 RALY DAZAP1 RALGDS RPS27 STARD3 EDF1 SAFB2 KLF13 CCS SPINT2 EEF1D MRPL12 GCDH PIN1 NDUFC1 TP53 AEBP1 ABHD17A SRSF9 LSM12 PDIA4 up
Clusters: 3 vs 1+2
fgsea_res <- fgsea_res_3v12
cond_nm <- 'Clusters: 3 vs 1+2'
fgsea_plot(fgsea_res$res_hm, pathways_title='Hallmark', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------------------------------------- ---------- ---------- ----------- ---------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## HALLMARK_GLYCOLYSIS 0.0012315 0.0040796 0.5277797 2.422178 0 188 GALE B3GALT6 ALDOB POLR3K LHX9 RBCK1 MPI LCT GUSB TPBG PAXIP1 CTH PMM2 CYB5A AGRN SLC35A3 PKM ENO1 GFPT1 HS6ST2 ALG1 CHPF BPNT1 TSTA3 CHST12 B4GALT2 EGFR ELF3 EFNA3 CHST4 GAL3ST1 ADORA2B CLDN9 CHPF2 IDUA B3GAT1 AGL TFF3 GMPPA B3GNT3 B4GALT7 CLN6 ANGPTL4 XYLT2 SLC25A10 HAX1 SRD5A3 QSOX1 B3GAT3 ANKZF1 HDLBP ALDH7A1 MET PSMC4 BIK PHKA2 COG2 PRPS1 PAM NOL3 GOT2 SDC1 PYGB PPIA NASP HOMER1 SLC25A13 GYS1 ALDOA SOX9 PKP2 GALK1 GNE B4GALT1 PLOD1 DPYSL4 PFKP SLC37A4 ANG ARTN CHST2 CASP6 SPAG4 PPFIA4 PGLS STC2 P4HA2 MIOX AKR1A1 up
## HALLMARK_DNA_REPAIR 0.0012469 0.0040796 0.5343831 2.376918 0 141 NME3 POLR1C CMPK2 ADRM1 GUK1 TAF6 MPG APRT NME4 ITPA NELFCD POLD3 GTF2A2 SNAPC4 VPS37B FEN1 SSRP1 SNAPC5 POLR2J GMPR2 UPF3B DGCR8 TAF12 CCNO SF3A3 GTF2F1 ELL TAF10 CANT1 POLR2E ALYREF NELFB TAF1C EDF1 SUPT5H POLR2C TP53 STX3 POLR2F ZWINT NT5C POLD1 DGUOK POLE4 NT5C3A RPA3 LIG1 GTF3C5 POLR2H PCNA ERCC2 SMAD5 ERCC1 RAD52 POLR2A GPX4 POLH DDB1 UMPS GTF2H3 ERCC3 NME1 DUT IMPDH2 SEC61A1 TARBP2 POLR1D TYMS DCTN4 AAAS POLA2 POLA1 POLR2I CDA SRSF6 POLD4 ADCY6 COX17 SAC3D1 PNP NPR2 DDB2 ERCC4 TK2 up
## HALLMARK_MYC_TARGETS_V1 0.0012346 0.0040796 0.5092858 2.337766 0 189 EIF3B PSMC6 GSPT1 RNPS1 POLD2 SF3B3 TUFM AIMP2 RPLP0 RPS5 PSMD3 TFDP1 RRP9 RPS2 RPS3 NDUFAB1 PSMB2 RSL1D1 RANBP1 TARDBP CLNS1A RPL18 PSMA7 SRPK1 HDGF TRIM28 CSTF2 RPL22 PPM1G NOLC1 NOP56 EIF3D SRSF1 SRM RUVBL2 SNRPD3 PSMA6 TXNL4A HSP90AB1 FAM120A CTPS1 XPOT CYC1 PSMC4 SF3A1 CCT7 CCT5 MRPL23 CCT3 CDK4 GOT2 GLO1 SNRPA PHB PABPC4 RPL34 SNRPD2 SSBP1 PPIA NHP2 MCM7 PCNA UBE2L3 CUL1 LSM7 C1QBP RPL14 IFRD1 RAD23B PA2G4 CCT2 NME1 APEX1 DUT IMPDH2 EEF1B2 ILF2 VDAC1 TYMS FBL DHX15 PSMB3 MCM2 HNRNPU ETF1 CBX3 KPNB1 RPS6 GNL3 PSMD1 HNRNPA2B1 YWHAE HNRNPA1 SNRPB2 MCM4 SERBP1 NOP16 up
## HALLMARK_OXIDATIVE_PHOSPHORYLATION 0.0012285 0.0040796 0.4964692 2.265552 0 175 PDP1 MFN2 ECI1 IDH3B RHOT2 MRPS15 AIFM1 CYB5A ACADSB NDUFAB1 OGDH MTRR SDHB PDHA1 SDHA ETFA SLC25A5 NDUFB2 NDUFS6 GRPEL1 SUCLG1 UQCRC2 NDUFV1 MRPL11 NDUFS3 NDUFB7 HSPA9 IMMT TOMM22 PMPCA TIMM9 RETSAT LRPPRC TIMM8B TCIRG1 NDUFS8 TIMM13 BAX NDUFS4 CYC1 POLR2F UQCR10 NDUFA4 ETFB MRPS11 TIMM50 GOT2 IDH3A UQCRH CS PHYH DLST FXN COX4I1 UQCRQ ACADVL TIMM10 GPX4 MRPS12 SLC25A4 NDUFS7 NDUFC1 IDH2 ECHS1 OXA1L NDUFC2 COX7C NDUFA1 VDAC1 ATP1B1 COX8A SLC25A11 MRPL34 CYB5R3 NDUFA2 COX5B COX7A2L NDUFS2 COX6B1 MTX2 AFG3L2 SUPV3L1 ECH1 MRPS30 COX17 up
## HALLMARK_ESTROGEN_RESPONSE_EARLY 0.0012315 0.0040796 0.4646747 2.137194 0 191 NAV2 DHRS3 ADCY9 ADCY1 TTC39A AKAP1 WWC1 NADSYN1 ISG20L2 TFF1 SLC7A5 MYBBP1A TPBG KCNK15 SLC37A1 DHCR7 LRIG1 LAD1 TFAP2C NXT1 FDFT1 THSD4 HR KRT8 ELF3 ASB13 DHRS2 ESRP2 RHOD P2RY2 FRK FHL2 NCOR2 ABAT OVOL2 CANT1 TMPRSS3 TFF3 CELSR1 MLPH SLC1A1 CELSR2 TJP3 CALCR PTGES TUBB2B TSKU KCNK5 PEX11A TBC1D30 PMAIP1 RHOBTB3 SLC9A3R1 MYOF RRP12 RPS6KA2 TIPARP TPD52L1 SVIL RAB17 ANXA9 KRT18 KLK10 KRT19 RARA SLC22A5 FAM102A CCND1 MUC1 KDM4B CLDN7 B4GALT1 SLC19A2 BHLHE40 AQP3 FOXC1 RAPGEFL1 WFS1 ABHD2 ENDOD1 DLC1 STC2 FARP1 MREG KAZN MED24 up
## HALLMARK_UNFOLDED_PROTEIN_RESPONSE 0.0012755 0.0040796 0.4597474 1.967681 0 103 EDC4 ZBTB17 IFIT1 EXOSC10 SLC7A5 NOP14 GEMIN4 ARFGAP1 RRP9 TUBB2A NOLC1 NOP56 ATP6V0D1 CXXC1 SHC1 EXOSC5 RPS14 HSPA9 EIF4G1 NFYA LSM4 PARN KHSRP EXOSC2 CHAC1 FUS PAIP1 IMP3 XPOT EEF2 ASNS DCTN1 YIF1A NHP2 SRPRB PSAT1 ERN1 BANF1 SLC30A5 EIF4EBP1 PREB WFS1 ATF4 DDX10 STC2 up
## HALLMARK_INTERFERON_ALPHA_RESPONSE 0.0013055 0.0040796 0.4648487 1.953420 0 93 ISG15 USP18 HELZ2 CMPK2 RSAD2 MX1 LY6E TRIM5 IFI35 OGFR HERC6 LGALS3BP CMTR1 RNF31 BST2 OASL MVB12A TRAFD1 PNPT1 IRF7 IFI27 ADAR MOV10 PARP14 IFI44L PSME2 IL4R OAS1 PSMA3 NCOA7 DDX60 PARP12 IFIT3 IFI44 IFIT2 STAT2 TRIM21 PARP9 RTP4 IFIH1 EIF2AK2 BATF2 up
## HALLMARK_E2F_TARGETS 0.0012315 0.0040796 0.4103838 1.887492 0 191 GSPT1 TBRG4 HMGA1 POLD2 PMS2 WDR90 CHEK2 RAD50 AK2 POLD3 DCTPP1 DNMT1 TUBG1 RANBP1 PPP1R8 HUS1 SSRP1 SNRPB POLE TIPIN NOLC1 NOP56 SRSF1 ILF3 NUP205 TACC3 CDKN2A POP7 KIF22 CCP110 PRKDC CTCF PLK1 SLBP DDX39A PHF5A TP53 CTPS1 ATAD2 PAN2 WEE1 PRPS1 CDK4 POLD1 POLE4 RPA3 LIG1 MCM3 NASP TIMELESS UBE2S MCM7 PCNA UBE2T LYAR CDCA8 PA2G4 PSMC3IP NME1 DUT TK1 RPA1 PAICS NUP107 MCM2 EZH2 POLA2 KIF4A CHEK1 DSCC1 E2F8 RRM2 MCM4 BRMS1L XRCC6 MYBL2 CSE1L SHMT1 PRDX4 RNASEH2A MKI67 PNN CDC20 CDC25B ASF1B LUC7L3 MXD3 MCM5 BIRC5 KIF2C RAN BUB1B AURKA NUP153 BRCA1 up
## HALLMARK_MITOTIC_SPINDLE 0.0012346 0.0040796 0.3989088 1.834008 0 195 NUMA1 STAU1 EPB41 CTTN TAOK2 CEP72 KIF1B RHOT2 GEMIN4 KPTN OPHN1 SHROOM2 TUBGCP6 CDC42EP1 CEP250 ARFIP2 TUBGCP5 BCR CLIP1 NET1 EZR ARL8A MAP1S CDC42BPA MARK4 ABR KATNB1 TUBA4A KIF22 BCAR1 ARHGEF11 MAP3K11 WASL CSNK1D FGD6 TRIO ACTN4 PLK1 MID1 LRPPRC SPTAN1 PCNT DYNLL2 ARHGAP27 BIN1 ARHGEF2 DYNC1H1 MYH9 INCENP KIF3B ARF6 CYTH2 KIF3C ATG4B ARHGDIA MID1IP1 MYO9B CLASP1 PXN CNTROB CKAP5 RHOF LLGL1 NCK2 CDC42EP4 FARP1 DLG1 KIF4A CD2AP TBCD TSC1 TUBGCP2 ABL1 YWHAE SAC3D1 KIF23 SUN2 ARHGEF12 AKAP13 NF1 RANBP9 ALMS1 up
## HALLMARK_G2M_CHECKPOINT 0.0012270 0.0040796 0.3931594 1.805787 0 187 E2F4 GSPT1 SLC12A2 NUMA1 HMGA1 MNAT1 CHMP1A SMAD3 SLC7A5 LIG3 TLE3 TFDP1 PML TNPO2 ARID4A HUS1 ODF2 PRMT5 POLE NOLC1 NCL SRSF1 ILF3 TACC3 KIF22 CHAF1A CTCF HOXC10 CBX1 PLK1 DDX39A E2F1 UPF1 CDK4 EGF INCENP CCNF STIL BCL3 MCM3 NASP DTYMK UBE2S CCND1 CUL1 TOP1 HIRA RAD54L ORC5 RAD23B EFNA5 RBM14 SFPQ NUP98 MCM2 HNRNPU FANCC EZH2 SQLE POLA2 KIF4A KPNB1 CHEK1 NUP50 SLC7A1 CDC6 ABL1 UBE2C PURA E2F2 KIF23 MAPK14 MYBL2 MKI67 GINS2 CDC20 CDC25B EWSR1 MCM5 CUL4A SNRPD1 BIRC5 KIF2C MARCKS AURKA DBF4 MEIS2 RASAL2 NEK2 KIF5B HSPA8 CKS2 PRPF4B TPX2 SMARCC1 SRSF10 HIF1A CENPE CDC45 DMD AMD1 TROAP BUB1 EXO1 PAFAH1B1 PRC1 CCNT1 ESPL1 up
## HALLMARK_MTORC1_SIGNALING 0.0012346 0.0040796 0.3697959 1.698730 0 190 PSMC6 CYB5B SC5D TRIB3 SLC7A5 ABCF2 CTH DHCR7 CYP51A1 ENO1 RRP9 TM7SF2 TUBG1 STIP1 FDXR YKT6 SQSTM1 ACACA PFKL DDIT3 NMT1 NUP205 TUBA4A HSPA9 PSMB5 PDAP1 IMMT TOMM40 PSMA3 PSPH PLK1 FKBP2 DDX39A PSMC4 SLC9A3R1 ASNS PHGDH DHCR24 NFYC PSME3 CCNF HMBS PPIA ELOVL6 LDLR NFKBIB PSMD12 PSAT1 ACLY PPA1 MAP2K3 ALDOA PSMD13 CCT6A IFRD1 SRD5A1 SLC1A5 ARPC5L ATP2A2 BHLHE40 SLC37A4 SERPINH1 SYTL2 RPA1 MCM2 PSMC2 SQLE SERP1 ETF1 SORD SDF2L1 RRM2 GAPDH GGA2 SLC2A1 HSPA5 MCM4 PNP DDIT4 PIK3R3 GMPS TCEA1 up
## HALLMARK_ESTROGEN_RESPONSE_LATE 0.0012255 0.0040796 0.3669513 1.689665 0 193 GALE SCUBE2 TFF1 SLC7A5 GPER1 TPBG METTL3 ST14 LSR DHCR7 TFAP2C TSTA3 CDH1 NXT1 FDFT1 SLC2A8 HR DLG5 MAPK13 DHRS2 AGR2 PRLR ASCL1 FRK PKP3 NCOR2 OVOL2 TMPRSS3 TFF3 HOMER2 ASS1 CELSR2 TJP3 MDK CALCR PTGES XRCC3 KCNK5 SLC9A3R1 MYOF RPS6KA2 BTG3 TPD52L1 ETFB PLAC1 PERP DCXR STIL CKB ANXA9 KLK10 KRT19 SLC22A5 FAM102A CCND1 TFPI2 TSPAN13 LLGL2 FOXC1 HMGCS2 IDH2 TST DNAJC1 RAPGEFL1 up
## HALLMARK_UV_RESPONSE_UP 0.0012453 0.0040796 0.3774558 1.682577 0 147 CYB5B MARK2 NPTXR CDC34 COL2A1 GLS WIZ LHX2 CLTB TCHH PSMC3 STIP1 FEN1 SPR CLCN2 BAK1 YKT6 EPCAM STK25 SQSTM1 GRPEL1 PARP2 IGFBP2 MAPK8IP2 KCNH2 BSG TUBA4A CDC5L PDAP1 TYRO3 CHKA SIGMAR1 ONECUT1 MRPL23 ASNS TGFBRAP1 BTG3 AGO2 STARD3 POLR2H ICAM1 CYB5R1 ALDOA RAB27A SLC25A4 AQP3 SULT1A1 TST DLG4 UROD up
## HALLMARK_INTERFERON_GAMMA_RESPONSE 0.0012285 0.0040796 0.3493228 1.607440 0 194 ISG15 USP18 HELZ2 CMPK2 RBCK1 RSAD2 MX1 LY6E OAS3 IFIT1 IFI35 MX2 OGFR XAF1 HERC6 LGALS3BP CMTR1 RNF31 BST2 AUTS2 MVP ZNFX1 PSMB2 OASL TOR1B PML TRAFD1 SECTM1 PNPT1 IRF7 IFI27 ADAR RNF213 PARP14 NUP93 PTGS2 IFI44L PSME2 PLA2G4A IL4R PSMA3 ST3GAL5 PSMB10 VAMP8 OAS2 DDX60 SRI IFNAR2 PARP12 IFIT3 IFI44 ISOC1 IFIT2 STAT2 TRIM21 DDX58 LYSMD2 RTP4 ICAM1 UPP1 BPGM PELI1 TNFAIP2 IFIH1 NOD1 EIF2AK2 BATF2 PFKP up
## HALLMARK_ADIPOGENESIS 0.0012315 0.0040796 0.3480448 1.592507 0 183 AIFM1 DHCR7 AK2 PEX14 ESRRA NDUFAB1 SDHB ABCB8 DHRS7 CD151 GRPEL1 SUCLG1 REEP6 PFKL NMT1 MCCC1 NDUFS3 NDUFB7 BCL6 CHCHD10 IMMT HADH ANGPTL4 RETSAT RMDN3 SLC25A10 MGLL YWHAG GADD45A CPT2 SLC27A1 RREB1 APLP2 CYC1 UQCR10 COQ9 PFKFB3 PIM3 ATL2 ORM1 CRAT ETFB RAB34 ELMOD3 IDH3A ARAF CS GPHN PHYH LIPE UCK1 AGPAT3 ELOVL6 SLC5A6 UQCRQ ACLY VEGFB ALDOA ACADS SLC1A5 GPX4 PTCD3 SULT1A1 ECHS1 TST BAZ2A PREB UBC MRAP CMPK1 COX8A up
## HALLMARK_P53_PATHWAY 0.0012346 0.0040796 0.3290935 1.511755 0 190 WRAP73 LIF TRIB3 ST14 PHLDA3 FGF13 TM7SF3 CCNK TCHH HRAS TRAFD1 PLXNB2 RPL36 RAB40C FDXR BLCAP EPS8L2 RPL18 BAK1 EPHA2 RPS12 DDIT3 TRAF4 PVT1 CDKN2A ABAT MKNK2 EI24 CCP110 RETSAT APP STEAP3 VAMP8 GADD45A TP53 BAX HEXIM1 FUCA1 TPD52L1 PRKAB1 SLC3A2 PERP SDC1 DCXR RALGDS HINT1 AEN PCNA MAPKAPK3 RNF19B UPP1 PTPN14 PITPNC1 SERPINB5 POLH CSRNP2 SLC19A2 IER5 SEC61A1 RRP8 PLK3 VDR ZFP36L1 up
## HALLMARK_MYC_TARGETS_V2 0.0014184 0.0041719 0.6531821 2.519265 0 57 TBRG4 MRTO4 NIP7 IPO4 NOC4L PES1 MYBBP1A NOP2 AIMP2 SLC29A2 GRWD1 RRP9 DCTPP1 MAP3K6 FARSA LAS1L NOLC1 NOP56 SRM TFB2M EXOSC5 PPRC1 PUS1 IMP4 PLK1 PPAN MPHOSPH10 PRMT3 RRP12 CDK4 TCOF1 PHB up
## HALLMARK_PEROXISOME 0.0025510 0.0070862 0.4104043 1.756496 1 103 NR1I2 DHRS3 ALB ABCB9 ACOT8 PEX14 MVP CTBP1 HRAS SLC35B2 PRDX5 LONP2 GSTK1 PEX13 CEL HSD3B7 FIS1 CLN6 RETSAT PEX11A HMGCL CRABP1 FDPS CTPS1 SLC25A17 GNPAT CRAT ISOC1 DHCR24 ACSL5 ERCC1 SLC25A4 ERCC3 PEX6 IDH2 MLYCD DLG4 ABCD3 up
## HALLMARK_CHOLESTEROL_HOMEOSTASIS 0.0027137 0.0071413 0.4443173 1.776773 1 69 ACSS2 SC5D TRIB3 GUSB TNFRSF12A DHCR7 MVD CYP51A1 TM7SF2 FDFT1 PCYT2 ABCA2 SREBF2 PMVK CHKA MAL2 ATXN2 FDPS MVK ALDOC FBXO6 ALCAM LDLR up
## HALLMARK_IL6_JAK_STAT3_SIGNALING 0.0039062 0.0097656 -0.3713105 -1.756443 0 82 CSF3R A2M CSF2RB PF4 IL1B CCR1 CD36 IFNGR1 ITGA4 ACVRL1 IL18R1 CXCL13 ITGB3 HMOX1 IL2RG PIK3R5 EBI3 PLA2G2A CBL IL6 CXCL11 CXCL9 CXCL10 CD14 down
## HALLMARK_ALLOGRAFT_REJECTION 0.0053476 0.0103391 -0.4951699 -2.618041 0 187 LY86 GPR65 IGSF6 TLR1 SRGN KLRD1 CCL4 CCL19 IRF8 PTPRC CD86 FGR CD8A LCP2 CFP IL15 PF4 MBL2 TLR6 ETS1 CCR2 C2 IL1B GZMB FCGR2B IL16 GZMA CD4 CD8B PRKCB CCR1 IFNGR1 CD1D CXCL13 CD3G IL2 CTSS CCR5 IFNG IL18RAP CRTAM NLRP3 CD28 SIT1 CCND2 IL2RG PRF1 TRAT1 JAK2 CD3E CD96 CD40LG HCLS1 CD3D ITGAL FASLG ELANE STAB1 GBP2 ABI1 IL18 IL10 RIPK2 IL6 F2R CXCL9 CD80 CD2 CCL13 LY75 ITK CD247 B2M HLA-G CAPG TLR2 SPI1 UBE2N CCL22 LTB FAS STAT4 down
## HALLMARK_INFLAMMATORY_RESPONSE 0.0053763 0.0103391 -0.3939447 -2.097843 0 193 CYBB CD48 TLR1 GPR183 CSF3R CMKLR1 SELE CCRL2 CD69 OLR1 RGS1 CALCRL C3AR1 LTA LCP2 FPR1 IL15 IL1B SLC31A2 MSR1 C5AR1 PTAFR CSF3 ABCA1 SELL IL18R1 LPAR1 ITGB3 IL7R P2RX7 PDE4B BEST1 ATP2B1 IL18RAP PTGER4 NLRP3 SLC7A2 TACR1 CCR7 RNF144B SLAMF1 VIP EMP3 PIK3R5 MARCO LAMP3 EBI3 STAB1 KLF6 ABI1 IL18 IL1A IL10 IL10RA RIPK2 IL6 CXCL11 CXCL9 CXCL10 CD14 APLNR HBEGF PROK2 AQP9 TLR2 CCL22 SLC28A2 MEFV CXCR6 EDN1 IFNAR1 NMUR1 PTGIR HAS2 ITGA5 down
## HALLMARK_KRAS_SIGNALING_UP 0.0052083 0.0103391 -0.3500591 -1.859115 0 190 LCP1 IL33 HSD11B1 TLR8 CMKLR1 F13A1 CLEC4A IRF8 PECAM1 EPB41L3 FCER1G PRKG2 C3AR1 LAPTM5 PDCD1LG2 GYPC ETS1 IL1B CD37 LY96 CDADC1 DOCK2 RELN IL7R CXCR4 CTSS ID2 ADAMDEC1 RETN SPARCL1 ACE MMP10 CCND2 ARG1 IL2RG TSPAN7 SPON1 TMEM176A FLT4 SERPINA3 MAFB SNAP25 TMEM176B GLRX GNG11 IKZF1 GPNMB ENG KLF4 CPE USP12 AKAP12 IL10RA CBL down
## HALLMARK_COMPLEMENT 0.0053763 0.0103391 -0.3315754 -1.765713 0 193 CR1 LTF PLEK GNB4 GZMK OLR1 FCER1G CR2 C9 FCN1 LCP2 LIPA C2 GZMB GNG2 GZMA CASP3 PRCP SH2B3 C1QA CD36 KYNU CASP1 PLA2G7 CTSS CASP5 GNAI2 ITGAM DOCK10 GNGT2 C1QC SERPINA1 ZEB1 ANXA5 IRF2 JAK2 PIK3R5 CD40LG CDH13 CTSC S100A12 PIK3CA GCA MMP8 IL6 SERPING1 DOCK4 S100A9 SCG3 ACTN2 PIK3CG CTSB CTSD C1R DGKH CLU PDGFB DUSP5 CFB MMP12 CALM1 APOC1 LRP1 C3 SPOCK2 down
## HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 0.0052083 0.0103391 -0.3202164 -1.697007 0 189 GLIPR1 DAB2 NTM FBN2 PTX3 PCOLCE2 IL15 ABI3BP VIM SGCG POSTN SLIT3 SLIT2 ITGB3 ID2 PMP22 SERPINE2 SGCB LUM SFRP1 TGM2 NNMT CXCL12 TGFBR3 ECM2 LOX EMP3 SGCD LAMA2 DCN VCAM1 VEGFC THBS1 LAMA3 FAP IL6 TIMP3 GEM DKK1 BDNF TNFRSF11B EDIL3 SNAI2 CAPG MGP CDH6 WIPF1 FAS ITGA5 LRP1 LGALS1 DST PRSS2 FBLN5 GREM1 PRRX1 VCAN MYLK MYL9 ITGB1 SERPINE1 PDGFRB COL6A3 FGF2 PLAUR FOXC2 FBLN1 CD59 PLOD2 RGS4 NOTCH2 JUN SPP1 RHOB CALD1 MFAP5 TIMP1 COL4A1 FN1 TPM4 FSTL3 SCG2 BMP1 TNFAIP3 FERMT2 CXCL1 FSTL1 INHBA FBN1 down
## HALLMARK_IL2_STAT5_SIGNALING 0.0052083 0.0103391 -0.2548213 -1.353321 0 190 FGL2 SELP LRRC8C GPR65 CD48 IRF8 CD86 CD83 CST7 TLR7 CASP3 IFNGR1 SELL IL18R1 SCN9A ODC1 SLC2A3 SYT11 EOMES GLIPR2 CD79B CCND2 TGM2 BCL2 PLIN2 TWSG1 IL1RL1 GSTO1 CCR4 BMPR2 GBP4 ICOS ITIH5 SMPDL3A KLF6 IL10 IL10RA down
## HALLMARK_BILE_ACID_METABOLISM 0.0077121 0.0142816 0.3575877 1.536092 5 109 NR1I2 GC PEX16 NR0B2 SLC27A5 HSD17B6 SLC35B2 PRDX5 FDXR SLC22A18 ABCA4 LONP2 ABCA2 GSTK1 NUDT12 PEX13 HSD3B7 PEX7 RETSAT CYP8B1 ABCG8 BBOX1 PEX11A PXMP2 GNPAT ISOC1 DHCR24 ACSL5 PHYH LIPE CH25H up
## HALLMARK_COAGULATION 0.0100000 0.0178571 -0.2769524 -1.395985 1 127 PLEK FGA OLR1 PECAM1 THBD A2M C9 P2RY1 PF4 MBL2 C2 VWF FGG C1QA ITGB3 C8B MMP10 SERPINA1 CFD KLF7 THBS1 APOC2 MMP8 TIMP3 ANXA1 SERPING1 CTSB C1R CLU PDGFB CFB APOC1 LRP1 C3 F2RL2 MASP2 down
## HALLMARK_PI3K_AKT_MTOR_SIGNALING 0.0191327 0.0329873 0.3314553 1.418601 14 103 FGF6 TRIB3 GNA14 AKT1 RPTOR TSC2 HRAS PLCG1 ARF1 EGFR SQSTM1 ACACA RPS6KA1 RAC1 DDIT3 PRKAA2 PAK4 MKNK2 PLCB1 ECSIT E2F1 CDK4 STAT2 NFKBIB PIN1 RPS6KA3 ARHGDIA MAP2K3 NOD1 GNGT1 AKT1S1 up
## HALLMARK_WNT_BETA_CATENIN_SIGNALING 0.0206186 0.0332557 0.4262231 1.539036 13 42 DKK4 AXIN1 FZD8 NCOR2 WNT1 CSNK1E PPARD TP53 MAML1 PSEN2 HEY1 CUL1 CTNNB1 DVL2 HDAC11 HDAC5 FZD1 up
fgsea_plot(fgsea_res$res_c1, pathways_title='C1 positional genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------- ---------- --------- ---------- --------- ------------- ----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## chr16p13 0.0011792 0.012239 0.6532959 3.089101 0 272 PRSS33 C16orf91 PDXDC1 GLYR1 PRSS41 UBN1 DNAJA3 JMJD8 SNRNP25 TRAF7 PGP NME3 CARHSP1 TBL3 PRSS22 E4F1 POLR3K GSPT1 RAB11FIP3 HMOX2 TELO2 MLST8 RNPS1 METRN WDR24 ADCY9 PAQR4 MRPS34 AXIN1 SRRM2 NOMO1 RHBDF1 RPUSD1 PDPK1 FLYWCH2 GFER UBE2I PRSS27 CLEC16A WDR90 MPG ZNF598 NTHL1 ZNF174 NMRAL1 STUB1 ZC3H7A CAPN15 TSR3 PPL ECI1 NPRL3 KCTD5 CCDC154 NTN3 MGRN1 ANKS3 PMM2 DECR2 RHOT2 MPV17L SLX4 SMIM22 HAGH NUBP2 NME4 NDUFB10 PIGQ BRICD5 EME2 THOC6 TNFRSF12A CREBBP TBC1D24 KREMEN2 TSC2 LMF1 GNPTG DNASE1L2 CHTF18 RPS2 ZG16B METTL22 WFIKKN1 ZNF205 ALG1 MRPL28 MAPK8IP3 NUDT16L1 RSL1D1 RRN3 RAB40C ZNF263 SOX8 COX6CP1 C1QTNF8 IFT140 TMEM186 ZSCAN32 ZNF500 LUC7L RMI2 CLCN7 RHBDL1 ZNF213 SNHG9 SNORD60 DNASE1 NAA60 CLDN9 MTRNR2L4 HAGHL ABCC1 OR1F1 FAHD1 HS3ST6 PDIA2 ABAT MIR3180-4 PKD1P6 FBXL16 ZNF597 PARN MIR5587 TRAP1 UBALD1 GLIS2 WASH4P C16orf90 USP7 IMPDH1P11 WASIR2 IL9RP3 SLC9A3R2 ROGDI TXNDC11 HCFC1R1 PKD1 AMDHD2 TEKT5 C16orf72 TFAP4 NPIPP1 PKMYT1 NOMO3 UNKL NPIPA1 BFAR NUBP1 ERVK13-1 CCNF TPSP2 IGFALS TIGD7 CLUAP1 GRIN2A MIR4718 FOPNL MIR3176 up
## chr1p36 0.0011062 0.012239 0.6192226 3.017059 0 395 SNORA59A ISG15 SSU72 RERE GALE SPEN CEP104 NOC2L DHRS3 VPS13D RNF207 AURKAIP1 DNAJC11 ATAD3A KLHDC7A DNAJC16 MRPL20 FBXO42 RER1 UBR4 PEX10 ATAD3B B3GALT6 DVL1 C1orf174 ATAD3C CDK11B ATP13A2 UBE4B PUSL1 MFN2 NPHP4 FBXO44 DHDDS SMIM1 UBE2J2 ARHGEF16 SRRM1 MTOR NADK WRAP73 PANK4 LYPLA2 LRRC47 ZBTB48 EIF4G3 GPN2 ZBTB17 TMEM222 AKR7A2 PHF13 VWA1 SDF4 DDI2 CCNL2 PLEKHN1 TMCO4 MRTO4 CASZ1 RCC2 RNU6ATAC18P TMEM201 NBPF3 EXOSC10 HES4 KIAA2013 MIIP FBXO2 MIR34A C1orf159 KIF1B ARHGEF10L ARHGEF19 EMC1 CDK11A PGAM1P11 ICMT AKR7A3 RN7SL574P CROCCP3 MIB2 CLCNKB SLC9A1 NR0B2 MST1P2 ARID1A AGRN RNF223 TP73-AS1 CROCCP2 LINC00337 ENO1 PEX14 LDLRAP1 CEP85 SZRD1 MTFR1L GRHL3 NIPAL3 NUDC PRDM16 SLC25A33 DFFA MAP3K6 UBIAD1 OTUD3 LINC00339 SDHB TNFRSF25 PARK7 MAD2L2 MMP23A DDOST CNKSR1 GPR157 TARDBP PER3 NOL9 MUL1 ACAP3 TRNP1 MIR429 SCNN1D MORN1 KLHL17 TPRG1L EPHA2 RPL22 CALML6 RPS6KA1 RHCE THAP3 ASAP3 WDTC1 CTNNBIP1 HES5 SRM MTND2P28 TCEA3 RPL11 SLC35E2B PDIK1L ALDH4A1 SKI TMEM51-AS1 CLSTN1 PAFAH2 MEGF6 LINC00115 AGTRAP CLCNKA PRDM2 ESPNP AKR7L NPPA STPG1 TMEM52 ANKRD65 PINK1-AS TNFRSF18 OSTCP2 IFNLR1 HMGCL CD164L2 MIR4689 RNU6-1265P DRAXIN FAM131C TMEM88B MIR200A FUCA1 CLCN6 FBXO6 ZBTB40 PLEKHM2 PAQR7 IFFO2 IL22RA1 NCMAP EPHB2 SLC45A1 UBXN10 NBPF2P GNB1 AUNIP PRKCZ TMEM82 KDM1A NBPF1 SYTL1 MST1L PLEKHG5 NMNAT1 PINK1 PIGV H6PD DFFB ACOT7 PITHD1 MTHFR MXRA8 MTATP6P1 CROCC TTLL10-AS1 MIR200B RN7SL614P GPATCH3 CROCCP5 RN7SKP269 TP73 TMEM240 ECE1 MIR4684 PLA2G2C TMEM51 PLOD1 MMEL1 TNFRSF14 CICP27 CHD5 AGMAT TTC34 up
## chr7p22 0.0013532 0.012239 0.6800156 2.784135 0 85 SUN1 ZDHHC4 GET4 EIF3B ZNF12 IQCE ADAP1 MAD1L1 PMS2 PMS2CL EIF2AK1 GPER1 USP42 INTS1 WIPI2 AIMP2 FBXL18 PSMG3 TNRC18 FAM220A TMEM184A SNX8 RNF216P1 C7orf50 BRAT1 RNF216 CHST12 AP5Z1 ZNF316 KDELR2 COX19 CARD11 DAGLB FOXK1 RAC1 RBAK C7orf26 MIR589 C1GALT1 ZNF890P PRKAR1B MICALL2 NUDT1 CYTH3 SLC29A4 ANKRD61 MAFK CCZ1B UNC93B2 TTYH3 GPR146 ALG1L5P GNA12 CCZ1 AMZ1 OR7E136P up
## chr16q22 0.0012610 0.012239 0.5953681 2.605647 0 132 E2F4 ACD EDC4 NOB1 PARD6A DYNC1LI2 DDX19A CYB5B EXOSC6 MARVELD3 CES3 SF3B3 NIP7 SLC7A6 VPS4A NUTF2 COG4 WWP2 SLC7A6OS C16orf70 TRADD SLC9A5 CENPT PSKH1 CES2 PRMT7 FTLP14 DDX19B HSF4 PDF DHX38 CDH1 TERF2 FBXL8 KIAA0895L CMTM4 VAC14 LCAT TMEM208 ESRP2 CHST4 RANBP10 ENKD1 FHOD1 RN7SL279P ELMO3 HAS3 PDP2 ATP6V0D1 THAP11 NFAT5 NAE1 SMPD3 ZDHHC1 CTCF CDH3 PSMB10 TANGO6 PDXDC2P ZFHX3 MIR1972-2 NOL3 DDX28 CES4A B3GNT9 up
## chr16p11 0.0012788 0.012239 0.6007665 2.593281 0 120 RNF40 TBX6 ZNF629 ASPHD1 KCTD13 CD2BP2 ZNF768 FBXL19 QPRT TAOK2 TUFM ZNF764 SRCAP SETD1A TBC1D10B KAT8 NFATC2IP ATXN2L PHKG2 ZNF646 ZNF747 FBRS SEZ6L2 MVP DCTPP1 SULT1A2 RABEP2 PRR14 CTF1 PPP4C TMEM219 BCKDK EIF3C HERC2P4 PRSS8 SH2B1 SEPHS2 SLC7A5P1 GDPD3 MAPK3 KIF22 STX4 HSD3B7 ZNF771 ZNF48 SLC6A10P HIRIP3 C16orf58 ZNF688 CDIPT FUS MAZ YPEL3 HERC2P5 ZNF689 ZNF668 ZNF785 BMS1P8 up
## chr7q22 0.0012438 0.012239 0.5799210 2.590718 0 153 MUC17 BAIAP2L1 SMURF1 CYP3A5 ZNF3 PPP1R35 KPNA7 LRWD1 TAF6 CUX1 PUS7 SRRT UFSP1 NAPEPLD TRIP6 LRCH4 ZNHIT1 TRIM56 NAT16 AP4M1 AP1S1 GIGYF1 ARPC1A AGFG2 TSC22D4 PLOD3 POLR2J SPDYE6 ZKSCAN5 GNB2 SLC26A5 ZSCAN25 ALKBH4 MIR4653 ACHE MIR25 TRIM4 ZSCAN21 TRRAP SLC26A4 POP7 MEPCE RN7SL750P PDAP1 FIS1 PILRB GPC2 SLC12A9 ZNF394 EPHB4 RWDD4P1 VGF NYAP1 CPSF4 COPS6 MOSPD3 KMT2E-AS1 POLR2J3 RN7SL549P LAMTOR4 STAG3L5P-PVRIG2P-PILRB DNAJC2 AZGP1 LARP1BP2 FBXO24 SPDYE2 MCM7 SRPK2 TFR2 PMS2P1 ARMC10 BUD31 ORC5 PCOLCE-AS1 STAG3L5P FAM185A RINT1 PTCD1 CLDN15 SPDYE2B MBLAC1 C7orf61 PSMC2 ZKSCAN1 ORAI2 MUC3A ARPC1B SPDYE3 ACTL6B S100A11P1 PRKAR2B PMPCB MUC12 DUS4L FAM200A NPTX2 GJC3 RN7SL8P up
## chr11q13 0.0011628 0.012239 0.5319871 2.530926 0 290 SNORD15B COA4 OTUB1 C2CD3 RNF121 FADD NUMA1 STARD10 PPFIA1 BAD INPPL1 PLCB3 AP001372.2 MARK2 CTTN PPME1 ZNHIT2 DGAT2 NUDT22 IGHMBP2 TRPT1 NADSYN1 CAPN1 PGM2L1 CLPB CATSPER1 FAM86C1 KLHL35 SLC29A2 DPP3 SHANK2 CCDC87 RCOR2 MACROD1 CST6 DHCR7 LIPT2 OR7E128P LAMTOR1 MIR194-2 GPR137 POLD3 RNF169 MRPL49 PPP1R14B GDPD5 RPS6KA4 RPS3 ESRRA VPS51 DNAJC4 LRP5 TM7SF2 SART1 MEN1 MRPL48 PRDX5 STIP1 RELA TMEM134 BRMS1 SCYL1 ATG2A SF1 FIBP OR7E126P OVOL1 MUS81 RHOD P2RY2 AP000439.2 HNRNPA1P40 NAA40 TRMT112 KLC2 PAAF1 SF3B2 FAU RCE1 EIF1AD NDUFV1 MRPL11 PITPNM1 DOC2GP MAP3K11 DPF2 FRMD8 CHKA GPHA2 CCS TSKU TIGD3 SSH3 CDC42BPG DRAP1 LTBP3 FKBP2 TCIRG1 NDUFS8 ACY3 CCDC85B RPS6KB2 NEAT1 CNIH2 PPP2R5B XRRA1 RIN1 PELI3 YIF1A KDM2A MRPL21 RBM14-RBM4 FLRT1 ANKRD13D CCND1 FOSL1 NUDT8 KAT5 VEGFB BANF1 CCDC88B CORO1B SYVN1 PLEKHB1 BATF2 HMGN2P38 SERPINH1 SPTBN2 CCDC58P5 CARNS1 RBM14 MALAT1 MAP4K2 LRFN4 RNASEH2C ALDH3B2 NRXN2 SIPA1 ZFPL1 COX8A PACS1 up
## chr1p34 0.0012092 0.012239 0.5416927 2.486156 0 192 ZSWIM5 MUTYH THRAP3 TRAPPC3 SCMH1 KIAA0319L NCDN C1orf122 INPP5B STK40 TMEM53 GNL2 ADPRHL2 DPH2 POMGNT1 MAP7D1 ERI3 MRPS15 FOXO6 CITED4 TRIT1 PTPRF COL9A2 MEAF6 PSMB2 ZMYM4 MANEAL RHBDL2 IPP ELOVL1 B4GALT2 OSTCP5 GPBP1L1 RN7SL503P IPO13 EBNA1BP2 C1orf109 HECTD3 AKIRIN1 SZT2 MED8 ZMPSTE24 RPL5P4 SF3A3 EIF2B3 RIMKLA MTF1 SNORD46 SNIP1 KDM4A YRDC ZC3H12A RNF220 CCDC24 EPHA10 CLSPN MAST2 RNA5SP44 HPCAL4 EXO5 CTPS1 C1orf216 NDUFS5 SNORA55 GJA9 PPIE NFYC RPS8 HIVEP3 PPCS DNALI1 COL8A2 HYI PABPC4 C1orf210 NASP RNU6-1237P SLC6A9 LSM10 AGO1 ZMYND12 ERI3-IT1 RIMS3 TMEM125 TSPAN1 RAD54L PPIH ZNF691 CDCA8 OXCT2 ZMYM1 DMAP1 BMP8B ARTN MMACHC RLF UROD SFPQ NT5C1A PLK3 FOXJ3 AKR1A1 C1orf50 up
## chr15q15 0.0013245 0.012239 0.5870245 2.483769 0 108 RPAP1 MAPKBP1 PLA2G4B TP53BP1 ACTBP7 ZFYVE19 DNAJC17 SPTBN5 MGA C15orf56 FRMD5 RPUSD2 ITPKA TMEM62 TUBGCP4 RTF1 SPINT1 INO80 GAPDHP55 PIN4P1 EHD4 PAK6 PPIP5K1 PLA2G4D CDAN1 ZSCAN29 RNU6-1169P PPP1R14D TYRO3 JMJD7 CHAC1 VPS18 RMDN3 RPS3AP47 HNRNPMP1 LTK DISP2 CKMT1A CASC4 BAHD1 LCMT2 VPS39 TMEM87A GANC MFAP1 C15orf62 LRRC57 IVD CKMT1B UBR1 ELL3 JMJD7-PLA2G4B KRT8P50 up
## chr1p35 0.0013263 0.012239 0.5906886 2.475239 0 99 SRSF4 IFI6 SNORA73B PHACTR4 MECR SESN2 BSDC1 SNHG12 SNHG3 TXLNA KIAA1522 TRNAU1AP EPB41 OPRD1 YTHDF2 RCC1 TMEM234 EIF3I TMEM54 PTPRU ZNF362 PEF1 AHDC1 AK2 KPNA6 PUM1 HPCA HDAC1 PPP1R8 SCARNA1 IQCC TRIM62 TAF12 EYA3 FAM76A MARCKSL1 SERINC2 SNRNP40 MED18 ZSCAN20 ZBTB8OS SNORD99 KHDRBS1 SNORA44 S100PBP XKR8 TSSK3 MIR5585 RNF19B TMEM200B SPOCD1 TMEM39B RBBP4 RN7SL559P ZCCHC17 MATN1-AS1 MATN1 ZBTB8B ZBTB8A DNAJC8 SDC3 SYNC up
## chr16q24 0.0013333 0.012239 0.5937259 2.464316 0 92 CTU2 GSE1 CHMP1A RPL13 SLC7A5 SPATA33 APRT ZC3H18 ZFPM1 MVD SPATA2L EMC8 ZCCHC14 PIEZO1 AFG3L1P CDT1 SPG7 ANKRD11 IL17C VPS9D1-AS1 CENPBD1 GALNS TUBB8P7 ZDHHC7 USP10 CDK10 ZNF276 VPS9D1 GAS8 TRAPPC2L TAF1C MTHFSD URAHP FANCA SPIRE2 FAM157C DEF8 ACSF3 ZNF778 FBXO31 CPNE7 BANP AC010536.1 FOXL1 KLHL36 PRDM7 TCF25 COX4I1 HSDL1 MBTPS1 KLHDC4 JPH3 MIR5189 KIAA0513 DBNDD1 up
## chr19p13 0.0010661 0.012239 0.4845519 2.409935 0 544 ONECUT3 GIPC1 UCA1 SMARCA4 AMH FEM1A FZR1 CCDC130 SLC35E1 GDF15 NR2F6 SH2D3A CDC34 STAP2 REXO1 BTBD2 CDC37 AP3D1 CHERP EVI5L MLLT1 LRRC8E CSNK1G2 GTPBP3 RFX2 TIMM44 SF3A2 PTBP1 CCDC159 STK11 TMEM259 TRMT1 BST2 LRG1 MEX3D ODF3L2 PIAS4 TICAM1 KRI1 XAB2 WIZ DUS3L LONP1 TMEM161A CACTIN THOP1 DNMT1 NACC1 EPS15L1 SCAMP4 MVB12A HOOK2 RPL36 ZFR2 DHPS BRD4 WDR18 ALKBH7 FARSA POLRMT TNPO2 KXD1 MAP2K2 CC2D1A RPL18A EEF1DP1 FBXL12 AKAP8L NR2C2AP MIDN ADAMTSL5 RFXANK MAP2K7 YIPF2 SNORD105B MPND KLF16 MIER2 RPS28 INSL3 REEP6 ATP13A1 TRIP10 SBNO2 MAP1S PCSK4 RNF126 ILF3 DDX49 C19orf44 PLEKHJ1 C19orf71 RPS15 DCAF15 AP1M2 GATAD2A RAB11B GADD45GIP1 CYP4F23P STX10 ZBTB7A GTF2F1 ARMC6 ELL GNA11 ANO8 ELOF1 AKAP8 SIN3B HMG20B TGFBR3L DOHH RFX1 BSG CAMSAP3 NDUFB7 ILVBL RAD23A MED16 LMNB2 B3GNT3 POLR2E CD320 PBX4 MKNK2 MED26 SGTA LSM4 KHSRP EIF3G TJP3 ADAT3 CCDC124 R3HDM4 DOT1L FBXW9 ANGPTL4 USE1 MIR3189 SLC39A3 ZSWIM4 CHAF1A GPR108 MRPL4 SIRT6 ABCA7 CERS4 ATG4D LPAR2 ECSIT CELF5 PPAN DPP9 NCLN ZNF317 GCDH RAVER1 ANKRD24 DDA1 C19orf67 WDR83 DDX39A C19orf57 CRB3 RN7SL192P TIMM13 SLC27A1 CILP2 DAPK3 DAZAP1 SUGP2 MADCAM1 SPPL2B BABAM1 EFNA2 PRKCSH UPF1 EEF2 ELAVL1 TPGS1 NDUFA13 PRR22 PDE4A UBXN6 C19orf53 FUT3 KLHL26 ZNF414 PIP5K1C QTRT1 MRPL54 KEAP1 MPV17L2 SSBP4 ZNF823 SAMD1 ICAM5 HAUS8 SH3GL1 TYK2 P2RY11 RNU6-9 SNAPC2 LDLR PIN1 ZNF560 TLE2 GNA15 TUBB4A MFSD12 ICAM1 SAFB2 TMEM205 UBA52 CPAMD8 CARM1 ABHD17A LSM7 MISP TCF3 RAB11B-AS1 ZNF77 KDM4B MYO9B DNM2 GPX4 ARHGEF18 ZNF443 NDUFS7 ZNF562 ZNF440 CIRBP-AS1 GRIN3B RGL3 SLC25A23 STXBP2 PKN1 TMEM38A APBA3 ATP8B3 GAMT JUND PCP2 RTBDN MAST1 SAFB FKBP8 RN7SL619P MRPL34 SUGP1 PGLS TMED1 FGF22 OCEL1 NFIC HNRNPA1P10 HSH2D PRDX2 CRTC1 ZNF558 MAU2 ZNF563 HSD11B1L C2CD4C PDE4C NDUFA11 PLIN3 COPE PALM3 C19orf25 TECR MBD3 up
## chr22q13 0.0011962 0.012239 0.4951000 2.297359 0 215 GCAT TTLL12 NPTXR MCAT ZBED4 PACSIN2 NCAPH2 CACNA1I GTPBP1 ZC3H7B LMF2 ANKRD54 JOSD1 TRMU WNT7B RPS19BP1 PPP6R2 RN7SKP80 TRABD PLXNB2 CHKB TUBGCP6 SBF1 CDC42EP1 L3MBTL2 ADM2 CBY1 TTC38 EP300 XPNPEP3 PICK1 TOB2 FAM227A SULT4A1 C22orf46 RANGAP1 UPK3A PDXP CPT1B BRD1 CARD10 RPL3 CDPF1 DNAL4 FAM83F MAPK8IP2 RRP7A TCF20 SYCE3 CELSR1 SREBF2 LINC00634 POLDIP3 TOMM22 PRR5-ARHGAP8 SGSM3 CHADL MICALL1 MAPK12 MRPS18CP6 CSNK1E APOBEC3B CBX6 ALG12 GGA1 PHF5A ODF3B ELFN2 ATXN10 ARSA POLR2F BIK EIF3L CRELD2 SLC25A17 PIM3 SCO2 TYMP LRRC37A14P TMEM184B GRAMD4 DENND6B TBC1D22A ARHGAP8 SLC16A8 SNORD83A PPARA SLC25A5P1 TEF NOL12 HDAC10 LINC00899 TRIOBP PANX2 MIR3619 ATF4 RIBC2 TAB1 CYB5R3 APOBEC3A DESI1 MIOX ADSL CHKB-CPT1B CERK PRR5 NUP50 TSPO RNU6-379P CCDC134 up
## chr20q13 0.0011765 0.012239 0.4819553 2.274809 0 265 DIDO1 HELZ2 MRGBP YTHDF1 NTSR1 TAF4 PRPF6 STAU1 ADRM1 CABLES2 OSBPL2 GID8 SPATA2 UCKL1 TCFL5 GNAS MIR941-2 RPS21 OGFR LSM14B SLC2A4RG ZNF512B SS18L1 KCNK15 SNX21 ZGPAT MTG2 ZSWIM1 ACOT8 DNTTIP1 ARFGAP1 ZFP64 DNAJC5 RPS4XP3 NELFCD ZNFX1 TTPAL MIR941-3 PIGT KRT18P4 RIMS4 TFAP2C SDC4 DDX27 TMEM189 ZNF334 MIR941-1 SAMD10 RBBP8NL ARFRP1 GMEB2 ARFGEF2 PMEPA1 RN7SL197P SLC2A10 MATN4 ZSWIM3 PSMA7 TOMM34 DBNDD2 TPD52L2 EEF1A2 ZMYND8 RTEL1 ATP9A B4GALT5 TP53RK VAPB ABHD16B RNF114 PPP4R1L PABPC1L ZNF335 CDH4 FITM2 SLC35C2 HNF4A COL20A1 LAMA5 ZFAS1 LINC00659 NPEPL1 LIME1 SEMG1 PCIF1 NCOA5 GNAS-AS1 SLC9A8 PARD6B RPL12P4 ZNF663P RAB22A WFDC2 ZNF217 RN7SKP184 PTK6 TCEA2 PI3 TSHZ2 SALL4 RTEL1-TNFRSF6B MOCS3 RNU1-134P PPDPF SLCO4A1 COL9A3 OGFR-AS1 up
## chr7q36 0.0013228 0.012239 0.5328100 2.236725 0 101 ACTR3B ZNF282 SLC4A2 ZNF398 ZNF777 NOM1 UBE3C FASTK TMUB1 PAXIP1-AS1 CDK5 PAXIP1 ABCF2 SSPO KMT2C SHH REPIN1 WDR60 MNX1 ZNF783 ZNF786 ESYT2 ZNF212 ZNF746 MNX1-AS1 AGAP3 GALNT11 ABCB8 ATP6V0E2 KRBA1 CHPF2 ATP6V0E2-AS1 ZNF862 KCNH2 LRRC61 RNF32 LMBR1 RBM33 ZNF467 SMARCD3 MNX1-AS2 YBX1P4 PDIA4 RNY4 PTPRN2 ZBED6CL LINC01003 CUL1 LINC01006 MIR153-2 ZNF425 ACTR3C EN2 PAXIP1-AS2 CRYGN ZNF775 EZH2 RNU4-31P MIR3907 WDR86 ASIC3 ATG9B XRCC2 MIR595 NCAPG2 RHEB up
## chr1q22 0.0014245 0.012239 0.5833563 2.180446 0 53 SCARNA4 GBAP1 RAB25 SMG5 EFNA1 RUSC1 UBQLN4 DAP3 PAQR6 MTX1 ASH1L-AS1 RHBG YY1AP1 LMNA ASH1L GON4L THBS3 SLC50A1 DPM3 SSR2 FDPS GBA ARHGEF2 CCT3 MEF2D MUC1 TMEM79 MSTO1 MSTO2P POU5F1P4 KRTCAP2 MIR92B DAP3P1 LAMTOR2 ASH1L-IT1 MEX3A SEMA4A SLC25A44 up
## chr7q11 0.0013643 0.012239 0.5357988 2.174546 0 81 TYW1 TMEM248 CRCP ASL VKORC1L1 PMS2P4 STAG3L4 RPL35P5 GUSB CCT6P3 SKP1P1 ERV3-1 AUTS2 DTX2 LINC00174 ZNF117 RSBN1L PMS2P5 GTF2IRD2 DTX2P1 GTF2I ZNF107 YWHAG ZP3 POMZP3 PMS2P3 STAG3L3 PTPN12 GTF2IRD2B NSUN5P1 KCTD7 SBDS FDPSP7 STAG3L2 ZNF138 SNORA22 NSUN5 SBDSP1 FDPSP2 SPDYE9P POM121C RABGEF1 up
## chr9q34 0.0011947 0.012239 0.4608896 2.137645 0 210 PAEP FCN2 ZMYND19 FIBCD1 MRPS2 ASB6 SNAPC4 TOR1B PTGES2 DDX31 ARRDC1 SNHG7 ANAPC2 QSOX2 ODF2 SOHLH1 RABL6 PRDM12 NDOR1 C9orf16 TPRN SAPCD2 TMEM203 MAN1B1 AGPAT2 ZDHHC12 ABCA2 MRPL41 CIZ1 EHMT1 ASS1 CEL LCN2 NELFB NSMF SEC16A PPP1R26 EXOSC2 PMPCA DPP7 C9orf106 BRD3 PRRC2B PTGES USP20 EDF1 SSNA1 SPTAN1 ENTPD2 NTMT1 NOXA1 ZER1 SH3GLB2 RNF208 GOLGA2 QRFP LCN12 C9orf163 CRAT WDR34 GRIN1 DOLPP1 CAMSAP1 NUP214 TUBBP5 DPM2 STXBP1 GPSM1 RALGDS SURF4 TOR4A UCK1 GTF3C4 GTF3C5 PTRH1 COQ4 FAM102A SURF2 INPP5E WDR5 NUP188 BARHL1 ENDOG FAM157B EEF1A1P5 NCLP1 TUBB4B FPGS FBXW5 PRRX2 NPDC1 TOR2A TRUB2 ABO MAMDC4 NAIF1 IER5L FAM166A DPH7 SLC34A3 C8G SWI5 TSC1 TMEM141 ABL1 CDK9 VAV2 SLC27A4 URM1 RNF224 FUBP3 ADAMTS13 DOLK NTNG2 POMT1 C9orf78 UBAC1 TRAF2 ENTPD8 PHPT1 TBC1D13 GLE1 MED27 ADAMTSL2 up
## chr5p15 0.0013643 0.012239 0.5311676 2.125470 0 71 SLC9A3 SLC6A3 MYO10 CEP72 IRX4 TPPP LINC01019 ZDHHC11B PLEKHG4B NSUN2 ZDHHC11 EXOC3 BRD9 MTRR SDHA CLPTM1L NDUFS6 CCDC127 SLC12A7 DAP PDCD6 EEF1A1P13 TRIO SPCS2P3 LPCAT1 CCT5 SDHAP3 RN7SKP79 DNAH5 SRD5A1 TERT SLC6A19 MRPL36 ZNF622 up
## chr1q42 0.0012690 0.012239 0.4913578 2.123414 0 119 SNORA14B GUK1 MRPL55 GNG4 C1orf35 TMEM63A IRF2BP2 PYCR2 MAP10 C1orf198 ARF1 TRIM11 TARBP1 B3GALNT2 ARID4B TRIM67 DNAH14 CDC42BPA TBCE JMJD4 TAF5L NVL RNF187 SLC35F3 ACBD3 LINC00184 URB2 CNIH4 EXOC8 FTH1P2 SNAP47 GNPAT FBXO28 COG2 TOMM20 SIPA1L2 GJC2 RAB4A OBSCN RNU6-968P SPRTN PSEN2 NUP133 ENAH ABCB10 FAM96AP2 KCNK1 PARP1 GGPS1 ARV1 COA6 C1orf131 TTC13 PGBD5 MIR5008 WDR26 FAM89A ITPKB LYST MIR4427 RNY4P16 CNIH3 BTNL10 GALNT2 TRIM17 CICP5 SDE2 up
## chr4p16 0.0012706 0.012239 0.4848173 2.094177 0 118 LETM1 STK32B SCARNA22 NOP14 CTBP1 TNIP2 NELFA RNF212 RNF4 AFAP1-AS1 MAEA BLOC1S4 RN7SKP275 GRPEL1 FGFRL1 PIGG C4orf48 TMEM175 NOP14-AS1 STX18 IDUA FAM193A TACC3 TRMT44 MFSD10 FAM53A TADA2B GAK ZFYVE28 DOK7 SLBP MRFAP1L1 MRFAP1 LRPAP1 HTT PCGF3 UVSSA DGKQ CPLX1 TMED11P TMEM129 MAN2B2 AC097381.1 SLC26A1 TBC1D14 EVC2 LYAR ALG1L7P ALG1L3P UNC93B7 FAM86EP WFS1 SPON2 MYL5 EVC ZBTB49 ZNF518B ACOX3 JAKMIP1 up
## chr16p12 0.0013369 0.012239 0.4813921 2.007311 0 96 TMC5 GTF3C1 HS3ST4 POLR3E KIAA0556 ZKSCAN2 NOMO2 EARS2 SBK1 TMEM159 EEF2K GDE1 NSMCE1 COG7 XPO6 NDUFAB1 LCMT1 UBFD1 CDR2 SMG1 NPIPB5 KNOP1 PALB2 UQCRC2 TMC7 EIF3CL IL4R ERI2 NPIPB3 CCP110 RNU6-1340P CRYM-AS1 PLK1 SYT17 DCTN5 TNRC6A up
## chr20p12 0.0014045 0.012239 0.5133717 1.969191 0 58 KIF16B LRRN4 FERMT1 SLX4IP RRBP1 CHGB RNA5SP475 CRLS1 MACROD2 ANKEF1 PLCB1 TRMT6 ESF1 FLRT3 TASP1 DSTN SPTLC3 MACROD2-IT1 BTBD3 PCNA ENSAP1 MACROD2-AS1 RPS3P1 GAPDHP2 BFSP1 RNU6-115P MCM8 up
## chr2q37 0.0012516 0.012239 0.4454080 1.956325 0 138 SCARNA6 UGT1A10 THAP4 AGAP1 B3GNT7 RAMP1 ECEL1 DIS3L2 ARMC9 GAL3ST2 ATG16L1 UGT1A13P COPS7B NGEF TIGD1 SH3BP4 SCARNA5 D2HGDH STK25 NCL RNPEPL1 CAPN10 ANKMY1 C2orf72 PASK MLPH TRPM8 DUSP28 AGAP1-IT1 LINC00471 KIF1A FARP2 RN7SL204P HDLBP PER2 GIGYF2 ING5 HDAC4 RAB17 DGKD DTYMK ATG4B SNORD20 TRAF3IP1 MSL3P1 SP140L NDUFA10 CHRND GPR35 SAG ILKAP CHRNG USP40 MIR562 PSMD1 BOK-AS1 SCLY HTR2B AQP12A ASB18 ASB1 PTMA RN7SL359P UGT1A7 NEU4 ARL4C SPP2 up
## chr17q25 0.0012048 0.012239 0.4174127 1.921580 0 202 LRRC45 UBE2O LGALS3BP RPTOR CCDC137 DUS1L SECTM1 GGA3 FDXR HID1 HGS CHMP6 NAT9 CBX8 CDR2L GPS1 CBX4 PCYT2 RNF213 OGFOD3 FOXK2 CCDC40 B3GNTL1 SLC38A10 PYCR1 EXOC7 CANT1 ALYREF OXLD1 MYADML2 RPL38 SLC39A11 CSNK1D EVPL SLC25A10 ARL16 P4HB MRPL12 FN3KRP RECQL5 MRPS7 SLC9A3R1 SLC16A5 RAC3 ARMC7 COG1 FSCN2 CCDC57 SIRT7 NT5C NPLOC4 TSEN54 RAB40B SMIM5 RFNG RPL9P29 DCXR TEN1 FBF1 SNHG16 SAP30BP RNU6-24P ZNF750 TBC1D16 LINC00482 TMEM104 TMC6 FADS6 ST6GALNAC1 ARHGDIA SRP68 WDR45B NUP85 GALK1 ANAPC11 TRIM47 TSPAN10 LLGL2 up
## chr7p21 0.0014472 0.012239 0.5320848 1.909113 0 45 COL28A1 ICA1 PHF14 RAD17P1 MACC1 AGR3 AGR2 RNU6-534P MIOS BZW2 MACC1-AS1 NDUFA4 RPA3 TMEM196 SCIN AHR SNX13 HDAC9 TSPAN13 SP8 TMEM106B ITGB8 RPL21P75 THSD7A GLCCI1 TWISTNB up
## chr20p13 0.0013661 0.012239 0.4687527 1.908657 0 83 SLC52A3 CENPB RBCK1 TRIB3 DDRGK1 PTPRA STK35 IDH3B ZCCHC3 MAVS ITPA FASTKD5 ACTG1P3 LZTS3 NRSN2 TBC1D20 MRPS26 SNRPB UBOX5 PANK2 FAM110A NOP56 C20orf96 SOX12 NSFL1C PCED1A UBOX5-AS1 RNF24 VPS16 C20orf27 AP5S1 PSMF1 up
## chr11p11 0.0013870 0.012239 0.4783295 1.886977 0 66 AMBRA1 PACSIN3 ZNF408 FNBP4 PEX16 CRY2 MAPK8IP1 PSMC3 ARHGAP1 SNORD67 CELF1 NDUFS3 ARFGAP2 MADD MDK TP53I11 CREB3L1 C11orf49 NUP160 DGKZ SLC35C1 SEC14L1P1 NR1H3 CKAP5 AC068858.1 RN7SL652P HARBI1 PTPMT1 ALKBH3 SYT13 SLC39A13 DDB2 ACCS MTCH2 TRIM53CP ATG13 TRIM49B ACP2 MYBPC3 TRIM51GP CD82 up
## chr14q12 0.0013870 0.012239 0.4773692 1.876181 0 65 NOP9 REC8 IPO4 RNF31 NFATC4 EMC9 AKAP6 RN7SL660P GMPR2 TM9SF1 RABGGTA LTB4R NUBPL KHNYN PSME2 DHRS1 RIPK3 HECTD1 STRN3 NYNRIN NRL HIGD1AP17 SDR39U1 DCAF11 FOXG1 COCH RPL26P3 ARHGAP5-AS1 CBLN3 MIR624 up
## chr15q24 0.0013587 0.012239 0.4544409 1.825644 0 74 MPI TYRO3P EDC3 CLK3 LMAN1L TSPAN3 RPP25 PML SCAMP2 ETFA COMMD4 NEIL1 FBXO22 SIN3A SCAPER RPL36AP45 MAN2C1 IMP3 ISL2 STOML1 DNM1P35 NEO1 MIR3713 RN7SKP217 FAM219B LOXL1 STRA6 RN7SL278P LOXL1-AS1 C15orf39 PSTPIP1 RN7SL510P PPCDC NRG4 SNX33 SNUPN KRT8P23 HIGD2B RCN2 COX5A ARID3B CSK UBL7 UBL7-AS1 up
fgsea_plot(fgsea_res$res_c2, pathways_title='C2 curated genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0013263 0.0119096 0.7421987 3.117606 0 105 PRSS33 C16orf91 JMJD8 SNRNP25 TRAF7 NME3 TBL3 PRSS22 POLR3K RAB11FIP3 TELO2 METRN WDR24 PAQR4 MRPS34 AXIN1 SRRM2 RHBDF1 RPUSD1 FLYWCH2 GFER UBE2I PRSS27 WDR90 MPG ZNF598 NTHL1 STUB1 CAPN15 TSR3 NPRL3 KCTD5 DECR2 RHOT2 HAGH NUBP2 NME4 NDUFB10 PIGQ EME2 THOC6 TNFRSF12A KREMEN2 TSC2 LMF1 GNPTG CHTF18 RPS2 ZG16B WFIKKN1 ZNF205 MRPL28 MAPK8IP3 RAB40C SOX8 C1QTNF8 IFT140 LUC7L CLCN7 RHBDL1 ZNF213 CLDN9 HAGHL FAHD1 HS3ST6 PDIA2 FBXL16 up
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0011211 0.0119096 0.6485693 3.099451 0 308 SUN1 RNF207 ATAD3A SLC52A3 ATAD3B EIF3B FBXO44 RNPS1 MTOR KCTD13 SRRM2 SNHG3 CC2D1B SMARCA4 GAS5 MARK2 GFER TBC1D22B FBXL19 RCC1 TMEM201 FNBP4 ZNF598 CAPN15 REXO1 MIIP SRCAP EVI5L SETD1A INTS1 ZMYND19 KAT8 CSNK1G2 LSM14B ATXN2L PTBP1 FBXL18 XPO5 PHKG2 RTKN ZNF646 POLM STK11 TMEM259 HIP1R ZC3H7B CMTR1 SRRT TMEM63A AGRN ABCF3 MDN1 SMG5 HHLA3 TICAM1 ANKRD54 NSUN4 PPP1R12C HSF4 TRMU HPCA CACTIN SNAPC4 LRCH4 PPP6R2 SCAF1 MAPK8IP3 TRABD CDC42EP1 COPS7B L3MBTL2 TNPO2 TARDBP MAP2K2 PIP5K1A AP5Z1 CPSF7 GIGYF1 ZNF316 IL17C PICK1 TMEM86B RPL18 TNPO3 EPN1 ZNF692 TEAD3 SF1 CCAR2 RANGAP1 GRIPAP1 ZBTB7B PDXP PPM1G UBAP2L DAGLB KLF16 ACIN1 LTB4R RHBG SBNO2 BRD1 SZT2 C7orf26 ILF3 GATAD2A TRRAP GBA2 ARMC6 APBA1 AMPD2 SH3BP5L U2AF2 EYA3 CLASRP HDAC7 MYPOP PPRC1 SFSWAP ZNF133 PUS1 KMT2D KDM4A LMNA ARHGEF11 KHSRP NPIPB3 LARP1 R3HDM4 SMG7 RBM33 SGSM3 DOT1L LEMD2 GPC2 SLC39A3 USP21 SLC12A9 MICALL1 ZMIZ2 FBRSL1 ZNF202 CSNK1E ABCA7 TAF1C MOGS LPAR2 DHX33 URB2 KCNK5 FANCA GGA1 PHF5A DAZAP1 SUGP2 PPARD SPPL2B POLR2F AP5S1 ARHGEF2 UQCC2 NEURL4 RASSF7 ZNF444 CTNND1 NUP214 QTRT1 NPM3 HAUS8 TCOF1 DENND4B MEF2D CIC GRAMD4 FXR2 TNK2 NSUN5P1 ERCC2 SAFB2 ANKRD13D SNRNP70 HIRA TCF3 MYO9B B4GALT1 THOC2 CNTROB ARPC5L HDAC10 TCHP MAPRE3 MSTO1 RBM14 TECPR1 APBA3 LLGL1 TPM2 GLP1R ABCC10 SMARCD1 PABPN1 SPON2 TTC13 MCTP2 up
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 0.0011442 0.0119096 0.6421231 3.018758 0 256 GALE AURKAIP1 BAIAP2L1 GIPC1 TMC5 GSS STARD10 SMARCA4 TTLL12 CHMP1A TMEM30B MYO10 PACSIN2 MYO6 MRPS18A NADSYN1 RASEF ST14 ICA1 CIB1 ZGPAT RAB25 TMEM259 HIP1R TMEM63A JTB SLC35A3 MRPL14 MVP GFPT1 RRBP1 CHMP4C EIF2B5 TACSTD2 TNIP2 SLC22A23 RABEP2 MROH1 HDAC1 VPS37B SCAMP2 SART1 RNF128 TSTA3 ARRDC1 TTC22 CC2D1A EPS8L2 FDFT1 CLPTM1L AGR3 ELF3 SLC2A10 EPCAM AGR2 KDELR2 ESRP2 SRPK1 NET1 DDAH1 IFI27 RPS6KA1 ZMYND8 RABL6 PREP C1orf116 FRK RNF126 PLEKHJ1 TOX3 TRAF4 GNA11 DOK4 GSTK1 DOHH OVOL2 CANT1 VSIG2 MRPL41 C1GALT1 MT-ATP6 POP7 TUBA4A RRP7A DNAJB2 MED16 EIF4G1 FUT2 IL20RA MKNK2 OXLD1 PLS1 TOMM40 MLPH TJP3 SGPP2 SGSM3 GRTP1 RALY GPR160 MGLL CTBP2 QSOX1 EDF1 EPHB4 PSMB10 CRB3 HDLBP GOLGA2 ARHGAP27 STYK1 AACS CCDC107 TSPAN8 ABHD17C MRPL52 NOSIP ERBB3 BZW2 MARVELD2 EHF ABCC3 FNIP2 TRAK1 GALNT3 SIRT7 VSIG10 MLLT6 BPHL ETFB BTBD3 ESRP1 PSD4 BSPRY EIF5B LRRC8B PPIA PWWP2B SH3BGRL2 LMAN2 F11R CCND1 TMEM129 TOP1 MANSC1 TMC6 UQCRQ LSM7 TMEM125 MUC1 MPST PPDPF up
## CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 0.0010953 0.0119096 0.6068748 2.969893 0 406 USP18 SUN1 PDXDC1 SLC52A3 JMJD8 NME3 GSPT1 AAGAB IQCE KIAA0319L PAQR4 STARD10 KIAA1522 RHBDF1 DDI2 TRIB3 FAAH TTC39A MARVELD3 CASZ1 TMEM30B KIAA0556 NR2F6 SH2D3A MYO6 CNNM4 TMPRSS2 ISG20L2 TFF1 RASEF EXPH5 GGCT DAAM1 ST14 ICA1 TLE3 EPS8L1 DLG3 ZXDC SLC29A2 RAB25 HIP1R SHANK2 LSR SIGIRR SLC37A1 CYB5A JTB EPHA1 SPATA2L TMEM184A CYB561 ANK3 TMED3 COG7 CHMP4C ARHGEF5 ZG16B SLC25A29 CGN DEGS2 RABEP2 FAM214A MYO5C LAD1 RUSC1 SCAMP2 HOOK2 TM7SF2 TRPM4 CDH1 RAB40C EPN3 UBQLN4 ARRDC1 MSX2 ARFIP2 RMND5B TMEM134 GPR157 MACC1 C6orf132 SPINT1 LMTK3 MAP7 PGAP2 HID1 ELF3 CACNA1D PRSS8 EPHB3 EPCAM AGR2 BCR PPP1R16A SEPHS2 ZBTB7B ESRP2 TMPRSS13 FOXA1 PRLR OVOL1 TNKS1BP1 PRR15 RBM47 MPP7 FAM110A ZNF74 ELMO3 ZHX2 TOX3 AP1M2 IGFBP2 GRHL2 PKP3 ALDH4A1 TRAF4 FREM2 RHPN1 SH3YL1 INPP5J GRHL1 TSTD1 ABAT CAMSAP3 OVOL2 MRPL41 ARFGAP2 TFF3 SFI1 RAB11FIP4 PROM2 PATZ1 MYO5B CBLC TADA2B MKNK2 ZBTB42 HOOK1 ERBB2 MLPH TJP3 ZNF467 EFNA4 OCLN TMEM45B SERINC2 MYH14 DOK7 DBP GPR160 LNX1 SSH3 MYO1D CDH3 PPM1H P4HTM GPD1L CDS1 TTC9 PPP2R5A TMEM191A ENTPD2 TBC1D30 FLAD1 ROGDI MAL2 TMEM183A PER2 PLEKHA6 MRFAP1L1 C1orf43 SLC9A3R1 CADPS2 BIK PRR15L ENSA IRF6 ERBB3 MARVELD2 EHF CAPN8 CSAD TPD52L1 DHRS13 SPINT2 PCK2 NOL3 PPCS GOLT1A RAB17 ESRP1 SYNE4 MCCC2 BSPRY AZGP1 ABCA12 DCAF11 ANXA9 KIFC2 GGT6 MUCL1 KIAA1211L PGAP3 PAGR1 GRAMD4 PWWP2B SYTL1 KRT19 KIAA1324 MGMT ARHGAP8 TNK2 SUCO FAM102A F11R CERS6 MPZL3 TMEM125 MUC1 TSPAN1 SCYL3 CKMT1B ENPP5 PPDPF GRB7 ULK1 VRK3 CHMP2A CLDN7 ELL3 PLCH1 JUP MMEL1 TSPAN13 LLGL2 SELENBP1 CCDC97 IDH2 DNAJC1 TMEM79 FANCF DDR1 RAB27B ALDH3B2 C4orf19 WFS1 CCDC6 PPP1R3D TMEM41A FXYD3 NPDC1 ABCC11 SYMPK RALGPS1 SORL1 ZNF385A PLXNA3 ZKSCAN1 MREG PRRG4 up
## REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION 0.0013514 0.0119096 0.7080354 2.898000 0 86 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 EEF1A2 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 EEF1D RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 EEF2 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 EEF1B2 up
## COLDREN_GEFITINIB_RESISTANCE_DN 0.0011820 0.0119096 0.6289971 2.885431 0 206 KCNMB4 SPINK2 TMC5 PRSS22 ADAP1 STARD10 KIAA1522 MARVELD3 GUK1 TMEM30B MYO6 GNAS STAP2 RASEF WLS PPL EXPH5 TMEM54 ST14 EPS8L1 MBOAT1 RAB25 SMIM22 LSR LRG1 SLC35A3 EPHA1 ADK CST6 GRHL3 STK39 CGN TACSTD2 MROH1 LAD1 SCAMP2 CDH1 EPN3 CNKSR1 TTC22 MACC1 EPS8L2 C6orf132 SPINT1 SMAGP MAPK13 ELF3 PRSS8 AGR2 ESRP2 OVOL1 RBM47 RHOD MPP7 CLDN9 FAM110A ELMO3 LIPH C1orf116 AP1M2 ERP27 GRHL2 PLEKHA7 KLC3 SH3YL1 GRHL1 RNF114 OVOL2 RAB11FIP4 B3GNT3 SLC1A1 TBC1D8B TJP3 SYTL5 TMEM45B KANSL1-AS1 MYH14 DOK7 GPR160 LNX1 TJP2 MYO1D QSOX1 CDH3 VAMP8 CDS1 HMGCL CYP2J2 HS3ST1 MAL2 MST1R PITPNM3 BIK PRR15L IRF6 ERBB3 WEE1 EHF CCDC57 SPTLC3 CAPN8 GALNT3 PRRG2 SVIL REPS2 SMIM5 PSD4 SYNE4 RIPK4 BSPRY ANXA9 PTK6 KIAA1211L SYTL1 KRT19 SH3BGRL2 MPZL3 AIG1 TMEM125 TSPAN1 ENPP5 MFSD6 CLDN7 LIMA1 up
## REACTOME_RRNA_PROCESSING 0.0011962 0.0119096 0.6311146 2.863090 0 184 NOB1 TBL3 UTP14A BMS1 PWP2 EXOSC6 NIP7 RPL13 NOC4L TSR3 ISG20L2 EXOSC10 PES1 RPS21 NOP2 RPLP0 NOP14 RPS5 NOL6 RPP25 RPL24 RRP9 NSUN4 RPS2 RPLP1 RPS3 DHX37 RPL36 RPL10A WDR18 RPL39 RRP1 RPSA NOL9 RPL18A RPL12 RPL18 ERI1 RPL35 RPL29 EBNA1BP2 RPL22 RPL13A LAS1L RPS12 NCL PELP1 NOP56 RPS28 RPL3 TRMT112 DDX49 RPLP2 RPS15 RPL11 FAU NAT10 TSR1 RPL32 RRP7A EXOSC5 RPS14 RPS11 IMP4 RPL38 EXOSC2 CSNK1D CSNK1E RPS20 IMP3 RPS29 MPHOSPH10 RPL37A UTP18 RPL31 HEATR1 RPS27 BOP1 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPS8 RPL37 WDR3 RBM28 RPS7 FTSJ3 RPL34 RPS16 RPS15A RPS26 RPL8 UTP3 RPL35A NHP2 RPS4X RPS27A RPL30 UBA52 UTP20 RPS23 RPL14 RPP38 ELAC2 UTP6 NOL12 RPL39L RPL41 RPL23 up
## KEGG_RIBOSOME 0.0013870 0.0119096 0.7063876 2.859103 0 81 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL41 RPL23 RPL4 RPL23A RPS13 up
## REACTOME_NONSENSE_MEDIATED_DECAY_NMD 0.0013298 0.0119096 0.6711097 2.822534 0 108 GSPT1 RNPS1 RPL13 RPS21 RPLP0 RPS5 SMG5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 SMG1 RPL35 RPL29 RPL22 RPL13A UPF3B RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 EIF4G1 RPL38 SMG7 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 UPF1 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL39L MAGOH RPL41 RPL23 RPL4 PPP2R1A RPL23A RPS13 up
## REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY 0.0013316 0.0119096 0.6792534 2.811195 0 94 TRIB3 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 DDIT3 RPS15 RPL11 FAU RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 ASNS RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 ATF4 RPS3A RPS6 RPL5 RPL26L1 CEBPB EIF2AK4 RPS24 up
## REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0013193 0.0119096 0.6665552 2.803698 0 104 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 DDOST RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 SSR2 RPS27 RPL27A RPL19 RPL28 RPL9 SEC61G RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A SRPRB RPL30 UBA52 RPS23 SRP68 RPL14 SRP54 RPL39L RPL41 RPL23 RPL4 RPN2 SEC61A1 RPL23A RPS13 up
## REACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS 0.0012240 0.0119096 0.6257830 2.790875 0 159 PSMC6 GSPT1 LHX9 RNPS1 RPL13 RPS21 RPLP0 RPS5 ISL1 PSMD3 RPL24 RPS2 RPLP1 LHX2 RPS3 PSMB2 PSMD11 RPL36 PSMC3 RPL10A RPL39 RPSA PSMA5 RPL18A RPL12 RPL18 RPL35 RPL29 PSMA7 RPL22 RPL13A UPF3B RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU PSME2 RPL32 PSMA6 RPS14 RPS11 EIF4G1 PSMB5 LDB1 RPL38 PSMA3 RPS20 PSMB10 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 PSMC4 RPL9 SLIT1 PSMD4 RPL36AL PSMF1 RPL27 RPS8 RPL37 RPS7 PSME3 MSI1 RPL34 RPS16 RPS15A RPS26 PSMC1 RPL8 ZSWIM8 RPL35A RPS4X RPS27A PSMD12 RPL30 PSMD2 UBA52 DAG1 RPS23 RPL14 PSMD13 PSMB4 RPL39L MAGOH RPL41 RPL23 RPL4 PSMC5 RPL23A RPS13 up
## REACTOME_METABOLISM_OF_RNA 0.0010593 0.0119096 0.5549670 2.777123 0 626 TYW1 SRSF4 EDC4 RPPH1 SNRNP25 NOB1 TBL3 PSMC6 CTU2 GSPT1 SRRM1 RNPS1 USP39 PRPF6 SRRM2 MNAT1 CD2BP2 UTP14A BMS1 PWP2 EXOSC6 SF3B3 NIP7 RPL13 EDC3 NOC4L TSR3 ISG20L2 EXOSC10 CWC25 PES1 CHERP AKT1 RPS21 METTL3 PUS7 NOP2 GTPBP3 SF3A2 PTBP1 TRMT61A RPLP0 SNRNP200 NOP14 RPS5 TRMT1 GEMIN4 SRRT CTU1 PSMD3 THOC6 SMG5 NSUN2 NOL6 TRIT1 XAB2 RPP25 RPL24 RRP9 NSUN4 RPS2 TRMU RPLP1 RPS3 PSMB2 PSMD11 DHX37 DHX38 SART1 TRMT12 RPL36 PSMC3 ADAT1 RNPC3 RPL10A WDR18 RPL39 RRP1 NXT1 RPSA PSMA5 LSM5 PRCC CLNS1A NOL9 RPL18A CPSF7 RPL12 RPL18 SMG1 ERI1 RPL35 SF1 SNRPB PRMT5 RPL29 EBNA1BP2 POLR2L PSMA7 POLR2J TNKS1BP1 CSTF2 RPL22 RPL13A DDX23 ADAR PRPF8 LAS1L UPF3B RPS12 NCL PELP1 NOP56 RPS28 RPL3 TRMT112 SRSF1 NUP93 DDX49 TFIP11 RPLP2 RPS15 NUP205 PRPF19 RPL11 TP53RK SF3B2 SF3A3 GTF2F1 FAU NAT10 TSR1 SNRPD3 DDX46 U2AF2 TRMT44 PSME2 RPL32 POP7 RRP7A EXOSC5 PSMA6 RPS14 CDC5L METTL1 RPS11 EIF4G1 POLR2E TXNL4A PSMB5 ALYREF PUS1 IMP4 POLDIP3 LSM4 PARN RPL38 KHSRP ADAT3 SMG7 DCPS EXOSC2 CSNK1D PSMA3 FUS TRMT5 TRMT11 CSNK1E PAIP1 APOBEC3B RPS20 PRKCA A1CF IMP3 SNRNP40 HNRNPUL1 SLBP PSMB10 RPS29 MPHOSPH10 TRMT6 NUP88 RPL37A UTP18 RPL31 DDX39A PHF5A WDR4 SUPT5H TPR POLR2C HEATR1 RPS27 BOP1 RPL27A XPOT RPL19 RPL28 DHX9 PSMC4 CPSF4 UPF1 POLR2F ELAVL1 SF3A1 RTCB RPL9 PAN2 PSMD4 WDR77 WDR33 PPIE NUP160 GEMIN8 RPL36AL PSMF1 RPL27 SNRNP35 ZBTB8OS RPS8 RPL37 NUP214 QTRT1 WDR3 DDX42 CNOT11 TSEN54 ZMAT5 RBM28 RPS7 PSME3 SNRPA LCMT2 FTSJ3 RPL34 NUP133 EFTUD2 SNRPD2 PCF11 RPS16 RPS15A RPS26 SNRPE PSMC1 RPL8 UTP3 RPL35A NHP2 POLR2H RPS4X RPS27A LSM10 PSMD12 ERCC2 RPL30 PSMD2 UBA52 LSM7 UTP20 RPS23 SNRNP70 DUS2 RPL14 RPP38 PSMD13 PSMB4 POLR2A NUP188 ELAC2 BUD31 NUP85 UTP6 THOC2 NOL12 RPL39L MAGOH PPIH RPL41 SNRPC RPL23 IGF2BP3 GTF2H3 ERCC3 IGF2BP1 GEMIN5 RPL4 PPP2R1A PRPF38A PSMC5 RPL23A RPS13 GEMIN6 HNRNPF RBM17 UBC TSEN2 PABPN1 ANP32A FBL XRN2 SRSF9 DHX15 ZFP36L1 SUGP1 POP1 APOBEC3A PDCD11 RPS3A PSMB3 NUP98 SYMPK NUP107 CSTF1 NUP210 PSMC2 APOBEC1 HNRNPU CCAR1 PUS3 POM121C DNAJC8 THOC3 ZC3H11A SF3B5 GAR1 ETF1 APOBEC2 PDCD7 AAAS POLR2I RPS6 GNL3 RPL5 RPL26L1 NUP50 WDR43 PSMD1 SRSF6 RBMX HNRNPA2B1 SMG6 NOP58 PRPF4 HNRNPM HNRNPA1 HSPB1 MAPK11 SNRPB2 RPS24 NUP62 PSMB6 NOP10 up
## LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 0.0011792 0.0119096 0.6056167 2.776294 0 202 SLC4A2 FADD MIPOL1 NUMA1 PPFIA1 ZNF3 INPPL1 LY6E TAF6 FASTK AKT1 CDK5 ABCF2 DPP3 JTB DHCR7 TFDP1 LAMTOR1 MTRR TSTA3 SDHA TMEM134 PRCC PI4KB BLCAP PIP5K1A CLCN2 CLPTM1L RMI2 EGFR YKT6 CCDC85C NDUFS6 CCDC127 PPP1R16A HDGF POLR2J BAZ1A ADAR ZNF74 GNB2 MAGEF1 ALKBH4 DDIT3 SLC12A7 ZSCAN21 KCNH2 NAT10 DAP SHC1 MRPL11 RAD23A METTL1 DVL3 EIF4G1 ARHGEF11 PDCD6 NKX2-1 PMVK USP21 USP13 STRN3 NUDT1 CCS HAX1 GCDH PYGO2 TMEM191A SSR2 RPS27 LPCAT1 PI4KA MET CCDC107 CCT5 MRPL23 COPS6 SEC61G JPH1 TRIM44 CDK4 CERS2 DUSP12 NUBP1 FIGNL1 NRDE2 IGSF8 AGO2 DENND4B KDM2A PAX9 PARD3 FAM131A B4GALT3 COCH MANBAL MCM7 POLR2H MED15 YY1 EAPP SRP54 PSMB4 CCT6A POGZ SRD5A1 MAF1 SLC39A1 CORO1B TPM3 TSFM S100A13 CRKL ILF2 FKBP9 MRPL36 FAM177A1 SIVA1 AP4S1 PPP1R3D DDX10 LANCL2 RTN4R TECPR2 ABCC5 NDUFS2 up
## REACTOME_INFLUENZA_INFECTION 0.0012563 0.0119096 0.6310041 2.772758 0 145 ISG15 KPNA7 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 POLR2L POLR2J CLTA RPL22 RPL13A RPS12 RPS28 RPL3 NUP93 RPLP2 RPS15 NUP205 RPL11 GTF2F1 FAU RPL32 RPS14 RPS11 POLR2E RPL38 RPS20 RPS29 NUP88 RPL37A RPL31 TPR POLR2C RPS27 RPL27A RPL19 RPL28 CPSF4 POLR2F RPL9 NUP160 RPL36AL RPL27 RPS8 RPL37 NUP214 RPS7 RPL34 NUP133 GRSF1 RPS16 RPS15A RPS26 RPL8 RPL35A POLR2H RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 POLR2A NUP188 NUP85 RPL39L RPL41 EIF2AK2 RPL23 RPL4 RPL23A RPS13 PABPN1 RPS3A NUP98 NUP107 NUP210 POM121C AAAS POLR2I KPNB1 RPS6 RPL5 RPL26L1 NUP50 up
## REACTOME_EUKARYOTIC_TRANSLATION_INITIATION 0.0013193 0.0119096 0.6522006 2.770340 0 112 EIF3B RPL13 EIF3I RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 EIF2B5 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 EIF3C RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 EIF3D RPL3 RPLP2 RPS15 RPL11 FAU EIF2B3 RPL32 RPS14 RPS11 EIF4G1 RPL38 EIF3G RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 EIF3L RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 EIF5B EIF2B4 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A EIF2B2 RPL30 UBA52 RPS23 RPL14 RPL39L RPL41 RPL23 EIF4EBP1 RPL4 RPL23A RPS13 up
## REACTOME_TRANSLATION 0.0011534 0.0119096 0.5881040 2.767696 0 262 AURKAIP1 MRPL20 EIF3B GSPT1 MRPS34 RPL13 MRPS18A TUFM EIF3I MRPL55 RPS21 EARS2 FARSB MRPS2 AIMP2 RPLP0 NARS2 MRPS15 RPS5 MRPL14 RPL24 MRPL49 RPS2 RPLP1 RPS3 EIF2B5 MRPL28 RPL36 MRPL48 DDOST DAP3 RPL10A RPL39 FARSA RPSA RPL18A RPL12 RPL18 MRPS26 EIF3C RPL35 MRPL17 ERAL1 RPL29 RPL22 RPL13A AARS2 RPS12 EEF1A2 RPS28 MTFMT EIF3D RPL3 TRMT112 RPLP2 RPS15 GADD45GIP1 RPL11 FAU EIF2B3 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 EIF4G1 EEF1D RPL38 MRPS35 EIF3G MRPL4 RPS20 MRPS33 MRPL12 MARS2 HARS2 RPS29 RPL37A RPL31 SSR2 RPS27 RPL27A RPL19 RPL28 MRPS7 TARS2 EEF2 MRPL23 RPL9 MRPL52 EIF3L MRPS6 SEC61G MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MRPS23 RPS7 RPL34 EIF5B MRPL21 EIF2B4 FARS2 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A SRPRB EIF2B2 RPL30 UBA52 RPS23 SRP68 MRPL10 CHCHD1 RPL14 MRPL27 PPA1 SARS2 SRP54 AIMP1 MRPS12 RPL39L PTCD3 RPL41 RPL23 YARS2 MRPS27 EIF4EBP1 TSFM RPL4 RPN2 OXA1L SEC61A1 RPL23A RPS13 EEF1B2 up
## REACTOME_SELENOAMINO_ACID_METABOLISM 0.0013175 0.0119096 0.6529731 2.746253 0 102 RPL13 RPS21 AIMP2 CTH RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 AHCY RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 SEPHS2 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 EEFSEC RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 AIMP1 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 up
## WELCSH_BRCA1_TARGETS_DN 0.0012853 0.0119096 0.6183726 2.666541 0 127 EDC4 EIF3B NME3 BMS1 SMARCA4 PWP2 RCC1 SLC7A5 CDC37 AP3D1 AIMP2 PHKG2 PIEZO1 HRAS FARSA POLRMT FDFT1 ANXA11 SSRP1 ATIC SRPK1 CLTA EZR UBAP2L NOLC1 NMT1 SRM AGPAT2 RRP1B SF3B2 SOX4 SF3A3 LMNB2 TRAP1 HK1 POLG NPIPB3 CKAP4 PMPCA CHAF1A TAF1C CHD4 MOGS SEC24C GTF3C2 HDLBP BOP1 CCDC85B CTPS1 CYC1 RPIA RASSF7 DHCR24 CDK4 ALG3 NUP214 POLD1 SON TCOF1 PABPC4 SSBP1 MLEC EIF2B2 SCAP GCSH CCND1 SNRNP70 NUP188 GALK1 SLC1A5 MRPS12 APEX1 PKN1 VDAC1 SAFB DDX10 PDCD11 MCM2 up
## HOLLERN_EMT_BREAST_TUMOR_DN 0.0013072 0.0119096 0.6185096 2.636083 0 114 ARHGEF16 STARD10 ATP6V1C2 SHROOM3 TMEM30B WWC1 TMPRSS2 STAP2 TMEM54 ST14 EPS8L1 RAB25 HIP1R LSR ILDR1 EPHA1 TMEM184A PTPRF TFAP2C CDH1 EPS8L2 SPINT1 MAP7 RHPN2 PRSS8 EPCAM ESRP2 TMPRSS13 EFNA3 OVOL1 ELMO3 AP1M2 GRHL2 PKP3 KLC3 LRBA GRHL1 TNK1 MYO5B CBLC EPB41L4B KIF21A CELSR2 TJP3 OCLN EVPL MYH14 CDH3 CRB3 MAL2 IRF6 ERBB3 MARVELD2 EHF ELOVL7 PLEKHG6 CKMT1A SPINT2 CEACAM1 ESRP1 RIPK4 BSPRY C1orf210 CCDC120 GRB7 KCNK1 CLDN7 JUP LLGL2 SPTBN2 TMEM79 DDR1 up
## NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON 0.0014881 0.0119096 0.7044214 2.634941 0 51 CTU2 GSE1 CHMP1A RPL13 SLC7A5 SPATA33 APRT ZC3H18 ZFPM1 MVD SPATA2L EMC8 ZCCHC14 PIEZO1 CDT1 SPG7 ANKRD11 IL17C CENPBD1 GALNS CDK10 ZNF276 VPS9D1 GAS8 TRAPPC2L FANCA SPIRE2 DEF8 ACSF3 ZNF778 CPNE7 BANP PRDM7 TCF25 COX4I1 KLHDC4 JPH3 DBNDD1 up
## LI_DCP2_BOUND_MRNA 0.0013736 0.0119096 0.6500180 2.620792 0 78 SPEN HMOX2 SRRM2 TRIB3 MRTO4 APRT RPS5 FAM50A ENO1 DUS1L DEAF1 PSMC3 RPSA MAP2K2 MTX1 POLR2L BAZ1A NOP56 FAHD2A RUVBL2 NDUFB7 EEF1D EIF3G CHAF1A TRAPPC2L EDF1 MRPL12 NDUFS8 TPR CYC1 NDUFA13 MRPL23 UBXN6 PHGDH SCO2 ETFB MRPS11 PITRM1 C12orf10 DCXR SAP30BP FLII TACO1 CHMP2A MRPS12 NDUFS7 UFC1 TST PSMC5 PDXK GATAD1 APEH CUEDC2 TSPAN31 TTC3 up
## SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5 0.0014184 0.0119096 0.6645432 2.611171 0 66 CD2BP2 SMARCA4 FZR1 NR2F6 CHERP FBRS SEZ6L2 XAB2 CDK16 OTUD3 RALGAPA1 LCMT1 HOOK2 ARID4A HAUS5 DHRS2 YIPF2 DCAF15 AP1M2 GNA11 SIN3B DNAJB2 MKNK2 NPIPB3 CERS4 SYT17 PKP4 TSN ZNF444 WDR33 VSIG10 KLHL26 RIPK4 DLX4 TLE2 F11R KDM4B ANKS1A ARHGEF18 CDIP1 ZNF443 ZNF562 ZNF34 SLC25A23 up
## WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP 0.0012771 0.0119096 0.5972584 2.593055 0 134 SH3RF1 TMEM30B MYO10 MYO6 RASEF GOLPH3 SLC35A3 CYP51A1 ARHGAP12 GFPT1 CHMP4C STK39 TMED4 RNF128 TSTA3 FDFT1 AGR3 MAP7 GGT1 EPCAM PHLDA2 KDELR2 NET1 DDAH1 CLDN23 GPATCH4 FRK TOX3 BRI3BP DOK4 PLS1 SGSM3 CASK EDEM3 GRTP1 SLC39A11 GPR160 CTBP2 QSOX1 EPHB4 MAL2 PDIA4 NME7 TSPAN8 ABHD17C SH2D4A ERBB3 BZW2 HINT3 ABCC3 FNIP2 OCIAD2 GALNT3 VSIG10 MLLT6 ETFB ASPHD2 PERP ESRP1 SAR1B LRRC8B ELOVL6 SH3BGRL2 F11R MUC1 KCNK1 ELL3 ARPC5L LLGL2 GMDS SYTL2 ETNK1 PBLD ATP1B1 FZD5 ABCD3 CMPK1 ABHD2 up
## CAIRO_HEPATOBLASTOMA_CLASSES_UP 0.0010638 0.0119096 0.5198474 2.588203 0 560 ACTR3B PIK3C2G EIF3B MLST8 TBRG4 POLR1C HMGA1 PRPF6 MNAT1 UTP14A POLR3E MAD1L1 SMARCA4 OSBPL2 RCC1 MRTO4 SF3B3 NIP7 IPO4 THAP4 NR2F6 MYBBP1A RPS21 GGCT LIG3 CHEK2 PUS7 PTPRA PAXIP1 ABCF2 RPLP0 SNRNP200 MAVS UBAP2 APRT MDN1 PRMT1 ENO1 ARMC9 RPL24 DDX41 AP1G2 TRMU NLE1 RPS3 DNMT1 DNAJC4 AHCY RSL1D1 CDT1 TUBG1 AAMP RPL36 CCDC47 DDX27 RANBP1 SUPT3H DDOST RPL10A FARSA CLNS1A RPL18A RPL18 SSRP1 ODF2 SNRPB PRMT5 DDX56 RFXANK EPCAM GPS1 ATIC UPK3A TOMM34 SRPK1 TRIM28 GMPR2 AP2B1 CIAO1 STK25 RPL22 TPD52L2 C1orf109 NOLC1 NCL NOP56 TAF12 SRSF1 RNF126 NUP93 ILF3 AATF NUP205 RUVBL1 MAN1B1 RPL11 USP10 RUVBL2 CPNE1 SNTB1 ERGIC3 CCNB1IP1 PNKP TRRAP GTF2F1 NONO NAT10 CHCHD2 TSR1 TCERG1 BSG POP7 SFI1 RPS14 KIF22 CIZ1 TXNL4A PSMB5 PUS1 IMP4 EEF1D LSM4 LRRC59 TRAP1 GTPBP4 SUPT16H EXOSC2 NAE1 TIMM9 PRKDC CHAF1A PSPH CDCA4 MAZ STOML2 MRPS33 CIAPIN1 RRS1 GTF3C2 P4HB SNHG14 PLK1 MRPL12 HSP90AB1 LRPPRC FANCA NCLN RPL37A UTP18 DDX39A ESF1 PRMT3 HDLBP HEATR1 BOP1 DAZAP1 SMARCB1 PI4KA MRS2 RPL19 RPL28 CYC1 MRPS7 PDIA4 PTK2 C20orf27 SF3A1 TASP1 CCT7 CCT5 EIF3L CCT3 BZW2 SEC61G MMS19 WDR77 CDK4 PSMF1 SNX5 MYL6B BFAR RPS8 TOMM20 POLD1 WDR3 DGUOK DDX42 MIS18A LIG1 FOCAD NPM3 UQCRH CCNF RAB4A DLST PHB PFAS PABPC4 EIF5B FXN MCM3 EIF2B4 TAF1D RPS16 KDM1A GART CSNK2A1 TIMELESS DGKD KRT19 HOMER1 SAP130 DTYMK MAPKAPK5 RPL8 NHP2 UBE2S ENOPH1 MCM7 TPGS2 GCSH WDYHV1 CERS6 FAM136A UTP20 C1QBP POLR3D RPL14 ACLY PPA1 SLC35F5 SLCO4A1 SAE1 CCT6A NUP85 UTP6 PARP1 SLCO4C1 ZFR RPL23 CDCA8 MRPS27 HIC2 CCT2 NME1 APEX1 LAPTM4B RPL4 MPZL1 CKAP5 RPN2 IMPDH2 OXA1L EEF1B2 ILF2 SFPQ FBL MYCN SRSF9 AARSD1 DDX10 KLHL7 RBM12 PDCD11 MCM2 DNMT3A LANCL2 NUP210 ADSL RFWD3 MSH6 EZH2 SQLE EIF3H GRK6 PLIN3 CTSV CBX3 KIF4A KPNB1 RPS6 CHEK1 GNL3 RPL5 EIF3M YEATS2 RRM2 CDC6 CENPN HUWE1 UBE2C PRDX6 MCM4 SERBP1 NCAPG2 NOP16 KIF23 CAPRIN1 HSF1 KDELR1 BYSL AGPAT5 XRCC6 MCM10 up
## MANALO_HYPOXIA_DN 0.0011299 0.0119096 0.5454821 2.587305 0 270 FBXO42 MFN2 POLR3K TELO2 TTLL4 USP39 HMGA1 POLD2 DDX19A UTP14A PWP2 MRTO4 IPO4 AKAP1 LRP8 CLPB LETM1 ABCF2 AIMP2 NARS2 FAM86C1 SRRT FERMT1 DHCR7 GRWD1 RRP9 PRMT7 RSAD1 NLE1 UBIAD1 PSMD11 TUBGCP4 TUBG1 RANBP1 RRP1 FEN1 GGT1 PRMT5 SNAPC5 ATIC EBNA1BP2 POLR2L CIAO1 PCYT2 TIPIN DDX23 NOLC1 NOP56 PARP2 ILF3 NUP205 RUVBL1 SRM RRP1B ARMC6 EIF2B3 NAT10 TSR1 NVL POP7 URB1 LMNB2 PUS1 GTPBP4 EXOSC2 CHAF1A FUS SLC25A10 MAZ PAIP1 RRS1 URB2 GPD1L NCLN POMT2 WDR4 HEATR1 BOP1 AMDHD2 PPARD CTPS1 C20orf27 PKMYT1 ZWINT WDR77 PRPS1 DHCR24 NUP160 RBM28 IDH3A PSME3 CCNF PHB PFAS STIL SAR1B HMBS FXN MCM3 PAK1IP1 GART NASP ELOVL6 UBE2S METTL2B BCS1L GCSH SLC5A6 FANCG FAM136A UTP20 C1QBP RRP15 MAP2K3 SLCO4A1 NUP188 NUP85 SLC1A5 PARP1 MRPS12 NOL12 RPL39L UMPS PA2G4 PSMC3IP CPN2 CISD1 NME1 TSFM TUBB4B GEMIN6 TSEN2 TOR3A ELK1 POLE2 SLC25A15 CD3EAP NUP98 MCM2 HEATR3 HNRNPU C3orf52 GMNN NEK4 DGCR11 POLA2 up
## SANSOM_APC_TARGETS_REQUIRE_MYC 0.0011792 0.0119096 0.5607771 2.577132 0 209 PRSS41 MUTYH GIPC1 TELO2 CCDC86 ZBTB48 RCC2 LRP8 MYBBP1A DPH2 ZMYND19 GTPBP3 FARSB TRMT61A SLC29A2 MDN1 TNFRSF12A CREBBP ARX EMC8 GRWD1 RAI14 RRP9 DUS3L PPP1R14B THOP1 NELFA SLC35B2 ADAT1 TUBB2A D2HGDH ZNF213 KNOP1 ZSWIM3 POLE DDAH1 MUS81 FHOD1 NOLC1 NOP56 HAGHL DDX49 TFIP11 SAPCD2 SRM CDC42BPA TP53RK SOX4 RAD23A GAS8 METTL1 SFSWAP LMNB2 VEZT LDB1 SMYD5 USP20 SIGMAR1 SRD5A3 AAR2 PPAN RPL31 NTMT1 WDR4 TP53 SMPD4 PTOV1 MVK CCT7 WDR62 WDR34 PHGDH ZNF444 CDK4 IFFO2 QTRT1 EPHB2 POLR1A CITED1 STOML1 PABPC4 MCM3 NASP TIMELESS SYTL1 HOMER1 DTYMK DENND6B NHP2 NRF1 MCM7 MYEF2 ATMIN ERCC1 ZBTB21 HIRA GORASP1 RAD54L NCEH1 TXNRD3 NME1 GEMIN5 ALKBH2 TK1 NSUN5 RPS13 RNASEH2C ANKRD39 NBEAL2 FBL NFS1 SIVA1 PDXK LANCL2 GAR1 ATRIP MBD3 AAAS FADS3 DRG2 ATG9B TMEM141 WDR54 ZFP2 SIDT1 PCBP4 METTL2A LFNG EXOSC1 SNRPF TRIB1 ERCC4 ARHGEF12 SHMT2 SHMT1 CAD RNASEH2A POMT1 GINS2 PTHLH PMM1 SLC1A4 SNRPG up
## WONG_EMBRYONIC_STEM_CELL_CORE 0.0011186 0.0119096 0.5343745 2.563466 0 318 ACAD8 POLR3K RNPS1 RCC1 MRTO4 RCC2 NIP7 GNA14 EIF6 RPL13 NTHL1 CDC34 EIF3I CHEK2 NOP2 TIMM44 MRPS2 RPS5 DPP3 NME4 NDUFB10 PRMT1 ENO1 KPNA6 EMC8 RPS3 TRIP6 NDUFAB1 DNMT1 HDAC1 PPP4C PDHA1 STIP1 DAP3 RPL10A FARSA RPSA PSMA5 LSM5 ETFA MAPK13 SLC25A5 EBNA1BP2 PSMA7 SEPHS2 RPL22 PPM1G RPS12 NCL IPO9 RUVBL1 RUVBL2 HNRNPAB NONO MRPL11 NDUFB7 POP7 MRPL37 HSPA9 KIF22 PSMB5 PUS1 LSM4 HADH CHAF1A MRPL4 STOML2 SNRNP40 PLK1 MRPL12 TIMM8B UTP18 PHF5A PRMT3 BTF3 TIMM13 CDCA7 RPS27 FDPS TP53 RPL27A BAX ALDH7A1 DHX9 PDIA4 POLR2F EEF2 CCT5 ALDOC EIF3L TMEFF1 WEE1 WDR77 PRPS1 CDK4 SNX5 RPS8 POLD1 RAB34 RPA3 UQCRH GLO1 PSME3 CCNF SNRPA TCOF1 PHB MCM3 RPS16 GART NASP ELOVL6 DTYMK HSPA14 NHP2 MCM7 LSM10 PCNA CCND1 FAM136A YY1 RPS23 MID1IP1 BANF1 UBE2V2 NIPSNAP1 PARP1 RAD23B CDCA8 PA2G4 EIF4EBP1 CISD1 SERPINH1 APEX1 ECHS1 BRIX1 SOX2 GEMIN6 YAP1 FBL POLE2 NUP107 MCM2 ADSL MRPS28 COX5B CTNNA1 NDUFS2 GMNN SQLE THOC3 NDUFA11 CBX3 NLN EIF3A KIF4A CHEK1 GNL3 RRM2 CDC6 SLC2A1 MRPS30 HNRNPA1 PSMB6 NOP10 CLPP MCM4 up
## AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 0.0011468 0.0119096 0.5406352 2.560855 0 276 TMEM248 LMTK2 YTHDF1 CRCP TAF4 ASL SMURF1 PRPF6 CYP3A5 FBXO34 MAD1L1 OSBPL2 GID8 TAF6 UCKL1 TCFL5 CEP72 GPER1 RPS21 INTS1 SPATA20 SS18L1 ZGPAT PRMT1 GRWD1 SNAPC1 NUDC RSAD1 EXOC3 BRD9 ZNHIT1 THEM6 SLC35B1 TSTA3 EPN3 SDHA AP4M1 CREB3 ZNF787 ARFRP1 RPL18 ARPC1A EPN1 NDUFS6 PSMA7 SHARPIN PLOD3 CLTA ZKSCAN5 TPD52L2 RPL13A ARHGAP35 GNB2 NUBPL NMT1 NR1H2 RUVBL2 ACSF2 TRRAP CASD1 U2AF2 PVT1 CDKN2A SLC26A4 PAK4 FIS1 EEF1D PDCD6 LRRC59 MICALL2 MLX SLC12A9 XYLT2 RCN3 NAPA DBP LAMA5 CBX1 PLEKHA4 SYT5 UTP18 ZC3H3 STRN4 LPCAT1 TMEM8B BAX CYC1 PPP1R13L PTK2 GSDMD KTN1 ASNS NOSIP ZNF444 RPL27 BECN1 COA3 WDR3 IRF3 LIG1 PSME3 MAFK ZNF623 PHB PON2 SNRPD2 SAMD4A PAF1 NFKBIB PMS2P1 GPATCH8 SLC25A13 KCTD7 GYS1 WDYHV1 LHB OPLAH SNRNP70 PON3 EAPP ACLY SARS2 MPP2 SLC1A5 MRPS12 ACTR10 GIPR PSMC3IP NME1 TPM2 ATP6V0A1 AP4S1 PLEKHG3 AARSD1 TMUB2 PPP1R3D CD3EAP PCTP ORAI2 G6PC3 DGAT1 ARPC1B SPAG9 EML2 PNPO RABGEF1 TAF2 KPNB1 up
## LIM_MAMMARY_STEM_CELL_DN 0.0010989 0.0119096 0.5227083 2.552055 0 387 GALE GABRP RER1 BAIAP2L1 GIPC1 SMIM1 FADD ARHGEF16 KIAA0319L STARD10 KIAA1522 PACSIN3 EPB41 MPI FAAH MARVELD3 CASZ1 TMPRSS2 STAP2 IFI35 PPL TMEM54 ANO9 COASY KIF1B ALG8 ST14 SUSD4 ICA1 DECR2 MBOAT1 CIB1 DLG3 RAB25 HAGH LGALS3BP LSR SIGIRR FGF13 ACOT8 SLC37A1 SLC35A3 ILDR1 DHCR7 SNX8 PTPRF TMED3 MVP AP1G2 HLCS CGN MYO5C TMEM62 TM7SF2 PIGO CDH1 ADAT1 TIRAP ZNF334 ARRDC1 HMGXB4 NGEF ATP6V0E2 SPINT1 SLC22A18 GOLM1 ATG2A KRT8 ARPC1A PGAP2 MAPK13 RHPN2 HID1 ELF3 SLC5A1 EPCAM TMPRSS13 DBNDD2 FOXA1 PRLR RBM47 RPL22 HDHD3 FAM110A ELMO3 REEP6 LIPH FRK AP1M2 PAK1 ZDHHC12 OS9 TPCN1 LRBA GSTK1 GRHL1 RFX1 CAMSAP3 MTUS1 RAB11FIP4 HOMER2 MYO5B CBLC BDH1 OXLD1 ERBB2 MLPH TJP3 TOM1L1 SGSM3 GRTP1 SLC39A11 ZSWIM4 RMDN3 EVPL NUDT1 MYH14 SSH3 TSPAN17 PPM1H ZSCAN20 CRB3 TCIRG1 CXCL17 CPT2 RREB1 ZFAND2B CORO2A SLC9A3R1 BIK PXMP2 ABHD17C SLC16A5 RAD51D ALDH5A1 BARX2 ERBB3 RAB11FIP1 TLR3 RASSF7 TFAP2A FBXO6 DHCR24 SNRNP35 CTPS2 NCOA2 SIL1 CEACAM1 WFDC2 MCCC2 BCL3 C1orf210 KRT18 PRKCZ PGAP3 KRT19 ZNF750 KIAA1324 COBL PAFAH1B3 VTCN1 SLC5A6 MANSC1 OPLAH IVD TMEM125 MUC1 SCYL3 FAM221A GRB7 MTA3 VRK3 CLDN7 TNFAIP2 ELL3 TRIM68 HDAC10 IBTK STXBP2 TST CLDN8 PKN1 CHCHD5 MIF4GD ALDH3B2 ATP1B1 PLEKHG3 TMEM41A RALGPS1 SLC39A9 SORL1 NUP210 ALAD IFT43 C1orf50 STAT6 TMEM139 PYROXD2 ANKRA2 up
fgsea_plot(fgsea_res$res_c3, pathways_title='C3 regulatory target genes', condition_name= cond_nm)##
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## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## FXR1_TARGET_GENES 0.0010163 0.0069322 0.5123317 2.624126 0 1002 KIF16B C16orf91 NOP9 DNAJC11 RNF40 DNAJA3 RER1 PEX10 ATAD3B TBX6 ZNF462 SNRNP25 PUSL1 POLR3K ASPHD1 TAF4 METRN SESN2 NUMA1 ADCY9 PAQR4 SMURF1 NOM1 PGBD2 LIF KIAA1522 TRNAU1AP MAD1L1 AMH ZNF3 INPPL1 FEM1A ZNF768 MPI FAAH UBE3C SNORA14B RCC1 EXOSC6 CASZ1 TMEM201 VPS4A PPP1R37 DDRGK1 TAOK2 RPL13 CXorf56 IGHMBP2 SPRED2 STUB1 CAPN15 CLK3 TSR3 NADSYN1 CWC25 ZNF764 SRCAP ABCB9 PPFIA3 FAM118B LSM14B SUSD4 KCTD5 NOP2 PHF12 DAGLA ATXN2L CDK11A TRMT61A ZNF609 SS18L1 RHOT2 ZGPAT HMGXB3 RPS5 AIFM1 HAGH PHLDB3 WDR55 CMTR1 LSR SIGIRR GEMIN4 FBRS SRRT SLC25A22 ARID1A PIGQ FRMD5 ZBTB45 SLC35A3 SEZ6L2 SLX4IP DHCR7 ARFGAP1 CHD8 FAM50A KPTN ARX RPTOR GRWD1 RAI14 LAMTOR1 PACS2 MTFR1L COG7 GNPTG ANKRD54 GTF2A2 MVP PPP6R1 WDR73 UNC45A TRIP6 PRR7 NELFA SIPA1L3 ALG1 MRPL28 ENTPD6 SLC35B2 SLC35B1 HOOK2 DEAF1 SART1 TRABD PPP4C BPNT1 PIGO RPL36 MNT LRRC73 AGK PRDX5 ADAT1 DHPS LSM5 TNPO2 CDR2 ANAPC2 PAQR6 LINC00630 B4GALT2 ARFRP1 LRRC14 MORN1 GMEB2 MTX1 MRPS26 ARFGEF2 ZNF213 INTS4 EPN1 ZNF692 CHMP6 DBNL ZNF839 DDX56 SNAPC5 DDX55 IRF7 KLHDC2 PSMA7 CD55 CCAR2 NEIL1 SHARPIN ZNRF2P2 CD151 DBNDD2 ATG9A PCYT2 UBTF C1orf109 NAA60 AARS2 NOLC1 ACIN1 ELMO3 TAF12 NOP14-AS1 TRMT112 OGFOD3 THAP3 TPRN ATXN7L3 DDIT3 NMT1 SRM RABIF FAHD1 TULP4 HNRNPAB SIN3A XXYLT1 PFDN2 PNKP SF3A3 JMJD4 SRRM5 AKAP8 KANSL3 MRPL11 GRHL1 TAF10 RNF114 MFSD10 TSTD1 NSFL1C KCNC3 C1GALT1 RRP7A SGMS1 DHRS1 MADD SREBF2 RNF32 EHMT1 B4GALT7 PDAP1 KMT2D PRKAR1B CAPN12 ZBTB42 POLDIP3 MED26 PLS1 LZTR1 MLPH MAP3K11 EIF3G TJP3 GTPBP4 MLX SGSM3 ZC3H4 FBXW9 EFNA4 SUSD2 PCED1A XYLT2 MAZ ABCA7 DBP PAIP1 INPP5K PRKCA SUMF2 PLEKHA8 TXN2 SEC24C LAMA5 HAX1 B3GNT8 THBS3 CDC42BPB ZFAS1 PPIL2 AAR2 PLK1 SLC50A1 SLBP MRPL12 SSNA1 VPS16 RPS29 RPUSD4 CNIH4 PYGO2 LTBP3 SMARCD2 FARP2 POMT2 ZC3H3 MAMSTR WDR83 FKBP2 GDI1 WDR4 TCIRG1 NKAP STRN4 SNX19 TIMM13 ATG14 ANKZF1 POLR2C RREB1 AMDHD2 ZFAND2B ATXN10 SNAP47 PARP12 TSN CORO2A CYC1 CNIH2 USF1 PTOV1 DAB2IP C9orf163 PPP1R13L PKMYT1 GBA TMEM179B BPTF POMZP3 ALDOC DNAH2 MARVELD2 XRRA1 TMEM144 NDUFA4 CRTC2 RPL36AL DHRS13 TYSND1 TOMM20 POLD1 RIN1 NPLOC4 DPM2 CASC4 MRPS11 TSEN54 MIS18A PAM BAG5 RBM28 PCK2 IMPDH1 NOL3 CRK AVIL RPS7 C12orf10 CITED1 CCNF RALGDS SLC9A2 HYI ZNF623 CYTH2 VPS39 FTSJ3 TOR4A SH3GL1 TRAPPC9 FAM193B RFFL HMBS HMGB3P22 UCK1 MRPL21 CAAP1 FAM131A GTF2H2C KDM1A CIC PTOV1-AS1 PTDSS2 SYTL1 SNRPE GTF3C5 CLUAP1 RARA ZNF579 ZSWIM8 DENND6B DTD1 CDKN2AIPNL PIGV METTL2B MFSD3 SH3BGRL2 ERCC2 TACO1 TOP3B F11R ANKRD13D DZANK1 CCND1 ATMIN EBF4 FOXA3 C1QBP FAM133B ARHGDIA ACADVL HIRA RRP15 MUC1 SCYL3 MRPL10 CHCHD1 PRDM15 ZNF77 LINC01006 ALDOA SLCO4A1 PSMB4 SAE1 ZNF544 POLR2A RAB27A FOXM1 VRK3 CHMP2A POLR2J4 CLDN7 MAF1 NUP85 SLC1A5 ELL3 ECE1 CORO1B PLCH1 NOL12 ANKDD1B TRIM47 ASB16 TSPAN10 DPCD SNRPC CSRNP2 COPB1 FKRP WDR87 PLLP RECQL4 HDDC3 PA2G4 CASP2 NDUFC1 MRPS27 CISD1 TSFM DMAP1 STX6 APEX1 TIGD6 SEPHS1 ARHGAP44 ZNF513 PSMC5 RHOF MPV17 MAP4K2 MSTO2P ALKBH5 ATP8B3 AHCTF1 WDR70 FBXW5 ATPAF1 C8orf76 KAZALD1 TBC1D10A AP2A2 RPS6KL1 UBC RTBDN SIPA1 KRTCAP3 AC007389.1 ELK1 COX8A TRIP11 CASP6 SPAG4 BICD2 IARS2 MLLT3 GPR35 SLC25A15 SYMPK NFIC DNMT3A LANCL2 CTSA NECAB3 PIP4K2B USP19 EIF2D NAGPA HSD11B1L VEZF1 NHEJ1 RBM42 POM121C INO80E ZMAT2 DGAT1 EML2 CDYL ACOX3 ATRIP IL17RC TAF2 ZNF576 RPS6 DPH7 PSTPIP1 MORC2-AS1 SEC1P IRF9 C8G MTHFS MXRA7 DRG2 SRSF6 MYLK3 ATP2A1 CDC6 SUPV3L1 CTXN1 MRPL3 COQ7 HUWE1 BRAP NAB2 IKBKE BCRP8 UBE2C ALKBH3 MED29 SAC3D1 CYBA FAM200A MDFI TXNDC16 ZNF211 NOP16 LRIG3 WDHD1 SEC13 DDX24 SLC4A11 ZHX1 SLC35E3 RBM23 DMKN ACCS SNTB2 TMEM147 ZNRF3-AS1 METTL15 SLC39A6 PIGM up
## THAP1_TARGET_GENES 0.0010030 0.0069322 0.5013630 2.605457 0 1667 ISG15 TYW1 SSU72 C16orf91 ACTR3B VPS13D NUDCD3 E2F4 AURKAIP1 ATAD3A MRPL20 DIDO1 DNAJA3 PEX10 B3GALT6 JMJD8 C1orf174 CDK11B PGP TBL3 MFN2 ZNF398 NPHP4 SNX18 E4F1 CTU2 DHDDS HMOX2 FADD YTHDF1 ARHGEF16 TBRG4 KIAA0319L LRRC47 MRPS34 CCDC86 PRPF6 RBCK1 DDX19A CD2BP2 SNHG12 NCDN POLR3E ZBTB17 TMEM222 SMARCA4 RPUSD1 BAD GID8 ZNF3 SDF4 TBC1D22B PRSS27 CCNL2 FAF1 EXOSC6 STK40 MCAT CCDC130 GUK1 TMEM53 WDR90 GDF15 MPG TAOK2 NUDT22 NMRAL1 IGHMBP2 RSF1 NOC4L WWP2 TRPT1 LINC00853 TSR3 ADPRHL2 GUSB TUFM ISG20L2 NCAPH2 ECI1 MRPL55 CHERP ZNF764 EVI5L ZKSCAN2 USP42 METTL3 FAM118B NPRL3 COASY ALG8 CSNK1G2 KCTD5 GTPBP3 PHF12 C16orf70 FIBCD1 CDK11A MRPS2 PTBP1 MKRN3 RAD50 RHOT2 PTPRU CIB1 FAM86C1 ICMT MRPS15 GBAP1 UBAP2 ZXDC C1orf35 ZGPAT MTG2 ZNF747 HMGXB3 RPS5 AIFM1 PEX16 TMEM259 NUBP2 ZDHHC5 ZC3H18 PLAGL2 SLC9A1 ZNF384 WDR60 RCOR2 FBRS PEF1 MST1P2 DNTTIP1 CTU1 ZBTB45 EME2 PHLPP1 DNPEP ANKRD13A FASTKD5 LMF2 SLX4IP CROCCP2 MDN1 ADK LINC00337 RRNAD1 SMG5 MVD CYP51A1 AUP1 NSUN2 KPTN KPNA6 PIAS4 PSKH1 UQCC1 SNX8 DDX51 RPTOR SZRD1 ARHGAP12 SLC27A5 XAB2 LMF1 GPR137 GNPTG RRP9 NIPAL3 DDX41 CHTF18 LONP1 RPS2 TM9SF4 PPP6R1 CCDC137 PPP1R12C NUDC TRMU TTPAL DUS1L PDF ZNF212 CACTIN VPS51 DNMT1 OTUD3 GCC1 ZNHIT1 OGDH ZNF746 SIPA1L3 RPS19BP1 ALG1 EPS15L1 LRRCC1 ATP13A4 PRR14 PYCR2 RUSC1 SLC35B2 THEM6 MAPK8IP3 DHX38 TRAFD1 HOOK2 C7orf50 TRMT12 TUBG1 RPL36 PSMC3 TMEM219 RAB40C HPS4 TUBGCP6 DDX27 ATG16L1 RANBP1 PRDX5 CEP250 SUPT3H FAM86GP IFT140 WDR18 IPP RPL39 SAMD10 ARFIP2 AP4M1 POLRMT PSMA5 DUSP8 SNHG7 MAP2K2 PPP1R8 RPL18A IWS1 AP5Z1 ZNF787 KDM5B IQCC UBE2M INO80 KRBA1 ARFRP1 RPL12 RPL18 CLPTM1L LMTK3 HUS1 MTX1 BAK1 CLCN7 PGAP2 TTLL11 ARFGEF2 YKT6 ZNF213 GPBP1L1 EPN1 AGFG2 AHCYL1 SNHG9 TRIM41 ZNF839 TTC31 PRMT5 ADAMTSL5 RFXANK SNAPC5 DDX55 PARP3 SH2B1 NDUFS6 SSR4P1 CCAR2 SHARPIN GDPGP1 PLOD3 COX19 TM9SF1 AP2B1 UBOX5 GALNS PDXP TPD52L2 SQSTM1 NAA60 DDX23 AARS2 EP400 RHPN1-AS1 NOLC1 REV1 PIGG RPS12 OSBP CYP4A22-AS1 TMEM175 REEP6 CFDP1 STX18 AKIRIN1 PCSK4 EIF3D THAP3 ZMPSTE24 NDOR1 PTRHD1 FAM13A C9orf16 ILF3 TFIP11 RPLP2 DNAL4 DNAH14 ATP6V0D1 TMEM203 RUVBL1 DROSHA CHMP4B MAN1B1 ST7 PKP3 SLC35E2B TULP4 RRP1B ZNF276 LGALS8 TAX1BP1 STX10 ZBTB7A GBA2 MGME1 JMJD4 MARK4 RHPN1 TAF5L SH3YL1 OS9 NAT10 CHCHD2 CLSTN1 SNRPD3 TACC3 NDUFV1 SH3BP5L SHC1 VPS9D1 TRMT44 RPL32 NDUFS3 RFX1 ZNF584 CANT1 KATNB1 RAB11FIP4 URB1 SGMS1 PSMA6 RPS14 RAD23A PABPC1L HSPBP1 MED16 RPS11 EML4 PITPNM1 EIF4G1 TXNL4A PSMB5 PTPN23 PEX7 ALYREF B4GALT7 LINC00115 OXLD1 IMP4 POLDIP3 GUCD1 MED26 NELFB SGTA BOD1 AGTRAP TOMM40 HK1 ERI2 POLG CCDC124 GAK USE1 EXOSC2 DPF2 ZNF688 ETV3 MAN2C1 USP21 DPP7 PCED1A TRAPPC2L TRMT5 MRPL4 ADCK1 SIRT6 POLR1B STPG1 NAPA DBP TRMT2A RPS20 MTHFSD IMP3 CTCF GON4L CIAPIN1 HNRNPUL1 GTF3C2 P4HB MPDU1 ZNF689 CDK5RAP1 THBS3 ZBTB11-AS1 TSPAN17 URB2 B3GAT3 EDF1 POLR3B RNF24 STRADB RIC8A GNAZ HARS2 SEC23B VPS16 DIAPH1 NCLN SYT5 ALG12 ZNF341 MED18 RPUSD4 GGA1 PHKB PYGO2 ANKRD24 LTBP3 HMGCL ZSCAN20 CCDC9 ZNF785 DDX39A MIR320A PHF5A DEF8 NOXA1 ACSF3 BTF3 GGNBP1 MZT2B LINC00881 SRI VGF AMDHD2 PPARD TP53 MADCAM1 ATXN10 RPL27A SMPD4 TOM1 SNAP47 BAX XPOT SLC37A3 SMKR1 FN3KRP RECQL5 ZNF778 CNIH2 USF1 PTOV1 PSMC4 ROMO1 CPSF4 MFSD5 C17orf75 TAPT1 TPGS1 GBA CCT7 BPTF COG1 ENSA ASNS CCDC92 SAMD4B COPS6 TOP1MT NFE2L1 CRELD2 DCTN1 COQ9 FBXO31 UVSSA PMS2P3 NEURL4 UBE2Q1 ABCC3 PPP2R5E CCDC57 TMEM144 WDR34 CLCN6 ZBTB40 CSAD DHRS13 TATDN1 RPL27 SNRNP35 SNX5 NOA1 BECN1 ZBTB8OS NUP214 ZNF79 POLD1 RBFA NPLOC4 CCDC142 SREK1 QTRT1 WDR3 DGUOK PRKAB1 MZT2A KHDRBS1 MIS18A LAMTOR4 MON1B MRPS23 RPA3 CRK TIGD4 CD46 RPS7 HDAC4 POLR1A BANP DGKZ ST7-OT4 TRAPPC2 PSME3 CS UBTD1 C2CD2L STOML1 VKORC1 KRTAP5-AS1 YIF1A FAM193B SAR1B BCL2L2 EFTUD2 MFAP1 LRSAM1 S100PBP MRPL21 FAM83G CAAP1 RNU6-9 EEFSEC C18orf25 CIC MKS1 PTOV1-AS1 WAC-AS1 SAP30BP PROB1 AKT2 PPIA ZNF664 PTDSS2 RPS26 MSANTD4 B4GALT3 SNAPC2 COCH HSDL1 STARD3 ZNF579 MANBAL NMNAT1 ZSWIM8 MLEC HSPA14 DLX4 PTRH1 NRF1 PIGV MBD1 MCM7 NFKBIB COQ4 PIN1 MZF1 PSAT1 LMAN2 MED15 MTHFR NDUFB9 ITFG1 FAM102A TOP3B LINC00649 SLC5A6 TMEM129 SERINC5 ATP11A UBA52 LNX2 TMEM9 FIZ1 RCCD1 ZNF497 SNRNP70 KAT5 POLR3D SRD5A3-AS1 HIRA SCYL3 SRP68 EAPP ACLY ZC3H11B TAZ GORAB LRRC37A3 VRK3 PTPN18 WDR53 AIMP1 DCBLD1 SRD5A1 UBAP1 MAF1 DNM2 GPX4 DSN1 TBC1D14 SPRYD4 ANAPC11 CDNF ZNF425 RNF123 RPL39L IRF2BP1 PTCD3 GLTP TSPAN10 SNRPC UMPS RBBP4 PDCL3 WDR87 CHAMP1 GNA12 BBS9 LYAR DHODH GTF2H3 KCTD21-AS1 YARS2 PA2G4 DPH6 CISD1 MSRB2 DNPH1 UBXN1 TMEM101 UFC1 PPP2R1A ZNF507 TIGD6 IBTK GRHPR STXBP2 TUBB4B DCAF6 OFD1 OXA1L TMEM79 TECPR1 TARBP2 AKT1S1 POLR1D UBAC2-AS1 CRKL CHCHD5 FPGS WDR70 BRIX1 ATG4A PREB MIR4258 C15orf41 SDHAF1 APMAP PTCD1 ILF2 SP2 RNASEH2C ABCC10 RPA1 SPSB3 MRPL36 FAM86EP MTCH1 RBM17 TMEM106B UBC SRRD SMARCD1 TMEM160 PABPN1 ANP32A ABCD3 DPAGT1 NFS1 CTNNB1 TAF3 SIVA1 KRBOX4 DCTN4 POLE2 PGLS ZNF484 FOXJ3 ZNF581 RPS3A TMED1 NUP98 TRUB2 SRA1 SLC39A9 AP2A1 WFDC3 CSTF1 SMYD4 LANCL2 METTL17 RTN4R CTSA DNAJC14 BAP1 FOXJ1 EIF2D ZBTB49 TBC1D17 NAIF1 METTL9 DVL2 NAGPA ABCC5 FANCC ATR HSD11B1L NDUFS2 DNAJC8 SF3B5 ZMAT2 EIF3H CHFR G6PC3 FTH1 N4BP1 ETF1 SPAG9 LASP1 USP40 COX6B1 ACOX3 MIR210HG CUEDC2 IPPK MBD3 TAB3 SENP5 COMMD1 STX16 MTX2 DPH7 FAM86C2P EIF5A PRKAR2B ACY1 SEC1P RPL26L1 CUL7 TRAPPC13 KIF27 NUP50 up
## GGAANCGGAANY_UNKNOWN 0.0013210 0.0069322 0.6099055 2.577217 0 103 E2F4 BMS1 RNF25 IGHMBP2 MRPS18A ZDHHC5 ZNF384 FARSA EPN1 DDX55 EBNA1BP2 SUPT6H SZT2 MED8 RUVBL2 TFB2M STK36 EIF1AD U2AF2 TAF10 CLASRP MTF1 SNIP1 PDAP1 ZNF597 RPL38 ZNF48 PCED1A TRMT11 SEC24C VPS16 GGA1 RPL28 SEC61G RIC3 CNST PRKAB1 MRPS23 MRPL21 SNRPE DLX4 MBD1 GYS1 UBA52 MOCS3 SRP54 PSMB4 BANF1 CHMP2A BUD31 TMCO1 UBXN1 SMUG1 PEX6 ZNF513 SEC61A1 TMEM38A FEV up
## CEBPZ_TARGET_GENES 0.0010091 0.0069322 0.4959479 2.560388 0 1304 TYW1 VPS13D DNAJC11 COA4 JMJD8 SNRNP25 TRAF7 CDK11B PGP NOB1 TBL3 NPHP4 SNX18 POLR3K AMBRA1 LMTK2 MLST8 MTOR WDR24 LRRC47 POLD2 NOM1 SNHG12 ADRM1 INTS5 BMS1 OSBPL2 CYB5B TP53BP1 INPP5B FLYWCH2 PMS2 CCNL2 STK40 MCAT CCDC130 TMEM53 FNBP4 IPO4 THAP4 PACSIN2 ZNF174 IGHMBP2 TSR3 FAM207A ISG20L2 ZNF830 CWC25 MIIP AP3D1 EVI5L MAP3K9 MORC2 MLLT1 DPH2 GGCT LRRC45 TBC1D10B KIF1B NFATC2IP KCTD5 GTPBP3 ZNF672 RFX2 ARHGEF19 EARS2 TIMM44 AIMP2 PTBP1 MGRN1 IDH3B RPLP0 GTPBP1 TRIP4 MRPS15 GNG4 CCDC159 TSPAN15 MCU POLM STK11 FAN1 DPP3 PEX16 ZSWIM1 HAGH NUBP2 WDR60 TRMT1 FAM220A FBRS NSMCE1 ACOT8 PCGF1 PEF1 MST1P2 ARID1A CYB5A FRMD5 PSMD3 BRPF3 CROCCP2 DHCR7 ARFGAP1 CHD8 MVD PRMT1 AK2 ENO1 NOL6 PEX14 RPTOR CEP85 XAB2 WIZ GPR137 GNPTG ANKRD54 NIPAL3 DDX41 RRBP1 CCDC137 PPP1R12C DDX19B DCTPP1 NUDC TRMU CHCHD3 ZBTB18 VPS51 SNAPC4 LRCH4 PSMD11 SPATC1L MROH1 ALG1 CCNK MRPL28 LCMT1 PYCR2 HRAS NGDN MAPK8IP3 DHX38 TRAFD1 C7orf50 AAMP RAB40C ZDHHC9 EMC9 ATG16L1 UBFD1 FAM120AOS STIP1 COPS7B DDOST ZNF354A ABCB8 ALKBH7 NXT1 POLRMT PSMA5 TMEM134 SPG7 ANKRD11 LSM5 HINT2 HMGXB4 ZSCAN32 CDR2 ANAPC2 RNF4 RPL18A RSBN1L FDFT1 INO80 SLC2A8 KIAA0895L RMI2 PGAP2 AKAP8L MAEA ZNF213 INTS4 GPBP1L1 AGFG2 GLOD4 HGS DDX56 TPRG1L DDX55 ZSWIM3 YIPF2 CCAR2 SNORD60 SHARPIN HDGF COX19 PDXP ATG9A RPL22 MED19 RPL13A C1orf109 NAA60 PANK2 RHPN1-AS1 PRPF8 ONECUT2 GRPEL1 PALB2 DGCR8 OSBP GOLGA3 RHCE RBM15 TRIP10 STX18 SZT2 MED8 OGFOD3 ZMPSTE24 NDOR1 ASAP3 CA13 TPRN DDX49 DNAL4 PDP2 PAAF1 RPS15 DCAF15 ZNF324B TMEM203 RUVBL1 NR1H2 GATAD2A DROSHA RAB11B FAHD1 RUVBL2 HNRNPAB SIN3A GOLGB1 PNKP SF3A3 ZDHHC12 ARMC6 FOXK2 RHPN1 TAF5L OS9 AKAP8 TPCN1 EIF2B3 CHCHD2 TSR1 EIF1AD SHC1 ABR TCERG1 TRMT44 C12orf76 NDUFS3 RFX1 RNF187 ZNF584 MTF1 KATNB1 MTMR12 SEMA4F MRPL37 MED16 KIF22 ANKRD16 SFSWAP VEZT CIZ1 B4GALT7 PBX4 PDAP1 ZNF597 OXLD1 CEP164 SGTA RPL38 TOMM40 MAP3K11 KHSRP NABP2 TRIM45 FAM76A LARP4B EDEM3 SLC39A3 MAN2C1 ZSWIM4 ZNF687 CDIPT CHAF1A DPH1 ZNF774 TNFRSF10B GPR108 MRPL4 FGD6 STPG1 ABCA7 DBP ARL16 IQCD STOML2 RPS20 TAF1C FAM222B SNRNP40 CCDC61 FAM98C HNRNPUL1 XRCC3 P4HB CDK5RAP1 ECSIT URB2 COMTD1 PSMB10 SSNA1 ISOC2 DRAP1 MPHOSPH10 SYT5 PPP2R5A TIMM8B DDA1 STT3A ZSCAN20 FLAD1 ROGDI DDX39A BCL2L1 ESF1 PHF5A DEF8 E2F1 NDUFS8 ATG14 ANKZF1 RGMB ERICH1 DCTN5 MAGI3 DAPK3 APLP2 C16orf72 SNX12 HIBADH CTPS1 RECQL5 NEAT1 BABAM1 COX14 TARS2 CPSF4 HTT MVK PDIA4 GBA CCT7 TMEM179B NRL ENSA TMX2 RPL9 RPIA UBXN6 SAMD4B CDK5RAP3 NFE2L1 NF2 C19orf53 TIMM22 PPP2R5E RASSF7 DOLPP1 CRTC2 NFYC MOSPD3 PSMF1 C12orf49 NCOA2 RPL37 NUP214 NPLOC4 MTR MYH9 INCENP MRPS11 MIS18A MPV17L2 LAMTOR4 RAB40B MON1B MRPS23 RBM28 WHAMM GLO1 RPS7 HDAC4 MIR4449 ZNF823 LINC01003 C12orf10 ZNF574 CS CCNF SNRPA GPHN PHYH CYTH2 YIF1A RNU6-1310P TYK2 DCAF11 SNRPD2 S100PBP PCF11 FXN MCM3 MRPL21 SSBP1 RNU6-9 TOM1L2 CIC SAP30BP PPIA RPS15A FBXO24 SND1 MSANTD4 GTF3C5 CHD6 MANBAL MAPKAPK5 BLOC1S3 NMNAT1 ZFP41 PAF1 TBC1D22A MBD1 ATG4B RGMB-AS1 PIN1 MZF1 PXMP4 RBM14-RBM4 EIF2B2 ERCC2 LMAN2 TACO1 PWWP2A FAM102A TOP3B DZANK1 KCTD7 GYS1 TMEM205 SLC4A1AP LNX2 TMEM9 MIEF2 IVD DUS2 HIRA RRP15 TCF3 RAB11B-AS1 ZNF77 HOMEZ SARS2 RSPRY1 GPATCH3 GORASP1 KDM4B BPGM BANF1 RAD54L POLR2A BAIAP3 ELAC2 WDR53 IFRD1 OTUB2 MAF1 BUD31 ZFYVE21 SLC1A5 DNM2 GNE CLASP1 MRPS12 SLC39A1 TBC1D14 JUP CCDC12 VPS72 TRIM68 TSPAN10 SNRPC UMPS ZNF691 ZNF443 GNA12 PLLP NDUFS7 DHODH GTF2H3 CDCA8 PSMC3IP ZNF138 NME1 GBF1 SPAG7 MPZL1 PPP2R1A TRIOBP TUBB4B BAZ2A DCBLD2 C14orf93 RBM14 TECPR1 TARBP2 TMEM38A AKT1S1 LLGL1 ALKBH5 POLR1D PEX1 TTC26 ATP8B3 FBXW5 FAM161A SDHAF1 TBCB APMAP PTCD1 SP2 KCTD2 SPSB3 ZCCHC17 TTLL5 ANKRD39 WFS1 MAST1 TMEM160 PABPN1 SFPQ ZNF837 HLTF UBALD2 ABHD2 COX8A TAF3 SIVA1 TMUB2 DCTN4 QPCTL ZNF726 TMEM41A MYL5 NDUFA2 ZNF581 PDCD11 PSMB3 NUP98 ZC3HC1 CCDC51 GLRX3 NUP107 AP2A1 CAMTA1 CSTF1 SETD3 RTN4R ADSL RFWD3 CTSA ZNF100 DNAJC14 ZNF547 ZC2HC1C EIF2D FAM126A SHKBP1 ZNF775 NAIF1 NAGPA ZNF563 ATR CLUHP3 IER5L RBM42 TSR2 ZMAT2 GRK6 NDUFA11 EML2 PNPO PLIN3 COPE ACOX3 ITFG2 FHIT SFXN5 TSPAN31 POLR2I KPNB1 STX16 HDAC11 SLC35F2 LRRC27 DPH7 VMAC SEC1P C8G TP53TG1 up
## SUPT20H_TARGET_GENES 0.0010101 0.0069322 0.4957121 2.552513 0 1169 SSU72 C16orf91 E2F4 AURKAIP1 DNAJC11 MRPL20 DNAJA3 ATAD3B ZNF12 TBL3 RNF121 CTU2 DHDDS MLST8 MTOR WDR24 CCDC86 PRPF6 MNAT1 DDX19A POLR3E INTS5 ZBTB17 TMEM222 BMS1 ZNF408 FEM1A UBE2I FBXL19 FAF1 PMS2CL LSG1 MRTO4 CCDC130 IPO4 SLC35E1 IGHMBP2 NOC4L TSR3 ADPRHL2 FAM207A ISG20L2 ZNF830 NCAPH2 CWC25 MRPL55 EVI5L CLPB ABCB9 USP42 TBC1D10B POMGNT1 COASY SLC7A6OS NFATC2IP KCTD5 GTPBP3 PHF12 FOXRED1 RFX2 ABCF2 EMC1 INO80B CDK11A IDH3B TRIP4 NOP14 USP54 GTPBP2 CCDC159 ZNF646 SAYSD1 HMGXB3 TMEM259 HAGH NUBP2 TRMT1 FAM220A PHF14 LGALS3BP ACOT8 PEF1 MST1P2 FRMD5 ZBTB45 PHLPP1 LMF2 ABCF3 CROCCP2 CREBBP RRNAD1 MVD PRMT1 AK2 NSUN2 UQCC1 DDX51 RPTOR SLC27A5 XAB2 GNPTG RPL24 ZNFX1 PRMT7 DDX41 RPUSD2 MRPL49 LONP1 PPP6R1 DCTPP1 CHCHD3 UNC45A ANKFY1 NDUFAB1 CACTIN VPS51 LRCH4 ZNHIT1 RN7SL1 MAD2L1BP ALG1 CCNK MRPL28 RALGAPA1 PIGT ATP13A4 NGDN DHX38 SLC35B1 C7orf50 RPL36 PSMC3 RAB40C HPS4 ZNF263 CCDC47 MRPL48 RANBP1 STIP1 CEP250 COPS7B RELA ABCB8 ALKBH7 ARHGAP1 SPG7 ANKRD11 LSM5 PRCC ANAPC2 NOL9 MUL1 AP5Z1 RPL12 RPL18 LRRC14 CLPTM1L AKAP8L TNPO3 GLOD4 ERAL1 TTC31 PRMT5 DDX56 RFXANK DDX55 MAP2K7 ZSWIM3 TMEM208 YIPF2 POLE CCAR2 SHARPIN PLOD3 HDGF AP2B1 RANBP10 C1orf109 DDX23 DAGLB ADAR LAS1L PIGG PALB2 KLHL20 RPS28 GOLGA3 RTEL1 RBM15 TRIP10 STX18 ZMPSTE24 NDOR1 RBAK FBXO22 SRSF1 ILF3 DDX49 NUBPL RPLP2 NMT1 DCAF15 TMEM203 RUVBL1 NR1H2 GATAD2A B4GALT5 RAB11B CHMP4B FAHD1 TMEM63C SIN3A ZNF276 SF3A3 ARMC6 FAU JMJD4 CXXC1 SRRM5 RCE1 SH3YL1 TPCN1 NAT10 EIF1AD MRPL24 VPS9D1 TCERG1 TRMT44 NVL CDK12 C12orf76 NDUFS3 RFX1 KATNB1 PEX13 EXOSC5 MYPOP RAD23A CDC5L PPRC1 STRIP1 RPS11 ANKRD16 SFSWAP PRPF18 SREBF2 STX4 EHMT1 PTPN23 RBBP5 B4GALT7 MOK KMT2D ALG10B POLDIP3 EEF1D BOD1 NFAT5 PDCD6 TOMM40 MAP3K11 TOMM22 KHSRP POLG SMG7 GTPBP4 DNAJC21 MCRS1 FAM76A FBXW9 DPF2 ZNF26 SLC39A3 MAN2C1 TIMM9 ZNF687 EMC10 ZFYVE28 MTND5P11 GPR108 MRPL4 TRMT2A IQCD STOML2 TSKU GAN MTHFSD FAM222B CIAPIN1 TXN2 HNRNPUL1 HAX1 XRCC3 DHX33 CDK5RAP1 ZFAS1 AAR2 MT-TP SSNA1 DPP9 ISOC2 LRPPRC RPS29 MPHOSPH10 MED18 THAP7 ZNF668 GCDH STT3A ZC3H3 WNK1 FLAD1 RPL31 WDR83 PHF5A EXOC8 WDR4 ACSF3 SMARCD3 TMEM183A MZT2B DCTN5 HOXC5 SUGP2 ACAD9 FDPS MRS2 SNX12 SPPL2B SMPD4 SNAP47 TSN RECQL5 RPS6KB2 PSMC4 VPS25 TARS2 C17orf75 MVK MED9 PPP1R13L PXMP2 C11orf49 ENSA RPL9 RPIA PDE4A NOSIP ARHGEF2 UBXN6 NFE2L1 NF2 TIMM22 RNU6-418P COQ9 RPRD2 PMS2P3 TIGD5 NBR2 CHRNB1 CRTC2 NUP160 PSMF1 PRRG2 BECN1 RPL37 NUP214 ZNF79 CCDC142 RHBDD3 DDX42 MIS18A KIAA0586 MPV17L2 MRPS23 RBM28 NPM3 RPS7 BANP CHCHD4 PSME3 FAM71E1 MAFK RAB35 CYTH2 SPRTN DNAJC2 TMEM87A SAR1B GANC EFTUD2 HMGB3P22 DCAF11 LRSAM1 MRPL21 EIF2B4 FARS2 SSBP1 EEFSEC TOM1L2 PAK1IP1 CIC MKS1 SAP30BP PAGR1 FBXO24 RPS26 SCFD2 GTF3C5 MT-ND1 MAPKAPK5 BLOC1S3 UTP3 NMNAT1 SCNM1 NFKBIB COQ4 PXMP4 LMAN2 TACO1 SAFB2 PWWP2A TOP3B DZANK1 TMEM205 SLC4A1AP TMEM9 SNX1 NPRL2 LSM7 RBM19 RTEL1-TNFRSF6B DUS2 HIRA RRP15 MOCS3 TCF3 RAB11B-AS1 ZNF77 GPATCH3 BPGM TUT1 BANF1 POLR2A DCAKD GK5 WDR53 MAF1 ZFYVE21 DNM2 UBR1 JUP GTPBP10 NR1H3 CCDC12 NOL12 CCDC106 MAGOH SNRPC C5orf17 NDUFS7 RPL23 RECQL4 ZNF131 CDCA8 SOX6 NME1 TSFM TMEM101 DMAP1 GBF1 SPAG7 PPP2R1A CCDC97 TIGD6 FAM185A TUBB4B TMEM38A NDUFC2 ALKBH5 RPL23A PEX1 TSSC4 LRRC29 TTC26 RPS13 WDR70 BRIX1 PREB PTCD1 ILF2 SP2 KCTD2 SPSB3 TMEM209 MMACHC TMEM106B RLF TTLL5 SRRD LAMA1 TMEM160 PABPN1 SAFB ABHD2 APTX SIVA1 SLC25A11 MT-TF AARSD1 DCTN4 TMEM41A NDUFA2 ZNF581 CD3EAP TRUB2 ZC3HC1 SLC39A9 NFIC NUP107 AP2A1 CAMTA1 SETD3 PSMC2 JARID2 BAP1 USP19 CTNNA1 EIF2D NAIF1 METTL9 NAGPA PEMT RBM42 POM121C DNAJC8 SF3B5 ZMAT2 GAR1 MED24 COPE KRTCAP2 ACOX3 THAP7-AS1 PDCD7 RNF167 AAAS POLA2 TSPAN31 COMMD1 ZNF576 STX16 RPS6 LRRC27 up
## EPC1_TARGET_GENES 0.0011074 0.0069322 0.5266016 2.530787 0 332 ISG15 SSU72 GALE TMEM248 SLC4A2 RNPS1 HMGA1 CCDC86 CLUH GSE1 ADRM1 PMS2 GFER YTHDF2 THAP4 NOC4L GUSB HES4 PGM2L1 FLVCR1 ZKSCAN2 SETD1A INTS1 LSM14B C16orf70 AIMP2 PTBP1 MKRN3 DECR2 ZGPAT HAGH REPIN1 MST1P2 ZBTB45 CROCCP2 MDN1 PKM PRMT1 NELFCD DDX51 MRPL14 EMC8 DUS3L PIEZO1 POFUT2 ESRRA ZNHIT1 DHX37 HRAS TRPC4AP CCDC47 RANBP1 RPL10A AP4M1 RPSA SNHG7 ARFRP1 TOB2 ZNF839 SF1 TMEM63B PLOD3 POLR2J KLF16 B3GALNT2 NCL NOP56 RABGGTA SLC25A51 FAHD1 CCNB1IP1 ECE2 MGME1 TAF5L EIF1AD U2AF2 ANPEP PINX1 TXNL4A PUS1 PDAP1 MRPS35 LRRC59 LARP1 MRPL4 MAZ TRMT2A LRRC56 HNRNPUL1 URB2 SLBP DIAPH1 ALG12 ESF1 TIMM13 SNX12 XPOT GNAS-AS1 MVK ZP3 RTCB GBA ASNS MMP15 CRELD2 TIMM22 CAMTA2 SPRED1 CCDC57 SNRNP35 SNX5 ALG3 SLC3A2 DDX42 CNOT11 GOT2 C12orf66 RALGDS SURF4 STAG3L3 S100PBP SKIDA1 F12 COX4I1 RPS26 MAPKAPK5 RPL35A SCNM1 UBE2S MCM7 RNF44 ATG4B MTHFD1L SCAP FBXO41 CERS6 UBA52 FBXW8 ARHGDIA DUS2 BANF1 WDR5 BUD31 SPRYD4 CCDC106 RAD23B BUD13 CCT2 ANXA2 DNPH1 NME1 TSFM COA6 MALAT1 RPL23A LSS HNRNPF ANP32A FZD5 DHX15 METAP1D FOXJ3 ZNF581 PDXK ZNF775 PEMT EZH2 G6PC3 GRK6 NDUFA11 COMMD1 KPNB1 VMAC EIF5A RNF145 DYNLT1 up
## ELF2_TARGET_GENES 0.0010341 0.0069322 0.5014870 2.530044 0 722 TYW1 NUDCD3 SLC52A3 SHB CDK11B OTUB1 RNF121 AAGAB RPAP1 TELO2 TBRG4 GTF3C1 WDR24 CD2BP2 ZBTB17 FZR1 FAF1 TMEM234 KIAA0556 EIF3I AP3D1 EVI5L TERC COASY NFATC2IP ATXN2L STK35 LRRC41 INO80B CDK11A PTBP1 PMM2 TRIP4 PHKG2 PEX16 ZDHHC5 ZNF384 PHF14 IRF2BP2 ZBTB45 ANKRD13A FASTKD5 SLC35A3 CYP51A1 ENO1 NUTM1 NOL6 UQCC1 RNF181 ARHGAP12 SLC27A5 LONP1 PPP6R1 PPP1R12C DDX19B UNC45A RPS3 CACTIN VPS51 LRCH4 RPS19BP1 PIGT ATP13A4 PRR14 LCMT1 SCAMP2 PPP4C CCDC47 TTI1 RNPC3 ARFIP2 PSMA5 SPG7 TXNDC17 ANKRD11 LSM5 FDXR ARID4A TMEM186 BNIP1 MUL1 RNF4 AP5Z1 ZNF787 FDFT1 INO80 PICK1 RPL18 STAMBP TNPO3 ODF2 HGS RHOQP1 DDX56 RPL29 KIAA0753 SH2B1 TMEM208 KIFC3 CLTA AP2B1 UBOX5 ZKSCAN5 RPL22 MED19 UBAP2L TOX4 OSBP ATP13A1 UQCRC2 ZDHHC7 CSNK1A1 AGAP2-AS1 EIF3D ZSCAN25 TPRN DDX49 C19orf44 TFIP11 RPLP2 AATF RPS15 NUP205 RUVBL1 AP1M2 RAB11B RPRD1B CHMP4B MAN1B1 RPL11 CAPN10 SF3B2 STX10 RN7SL2 ELL OS9 ELOF1 CHCHD2 SLC38A10 U2AF2 NVL CDK12 C12orf76 RPL32 KATNB1 SMARCC2 RPS14 GMPPA HSPBP1 METTL1 SREBF2 SNIP1 RBBP5 FIS1 ALG10B CEP164 RPL38 TOMM40 GPATCH2 GTPBP4 FBXW9 USE1 MALSU1 GHDC ZNF688 ZNF26 ACBD3 UBE4A ZNF774 ZNF394 ARL16 SIGMAR1 SPATS2L GON4L CCDC61 GTF3C2 AAR2 SLBP ZNF107 SEC23B LRPPRC RPS29 DPM3 DIAPH1 NCLN TRMT6 ZNF317 GGA1 PKP4 UTP18 FLAD1 TXNDC12 WDR83 DDX39A PHF5A EXOC8 CRB3 PRMT3 WDR4 TMEM183A RPS27 LINC00893 FDPS RPL27A RPL19 C1orf43 COX14 VPS25 POLR2F RRP12 CCT5 TMX2 RPIA UBXN6 PMS2P3 WDR34 MRPL33 MRPL51 SLC25A14 NFYC MOSPD3 RPL27 KLHL26 NOA1 BECN1 PHF23 RPL37 NUP214 RIN1 ANKRD42 HECTD4 NUBP1 DGUOK INCENP PRKAB1 DDX42 SIL1 MRPL54 AC092118.1 LAMTOR4 MON1B MRPS23 BIN3 PPCS TIGD4 UQCRH RPS7 POLR1A STAG3L5P-PVRIG2P-PILRB PSME3 DDX28 ZNF217 HAUS8 MPLKIP KTI12 VPS39 FTSJ3 SPRTN STIL RPL34 COPG1 MFAP1 TMEM67 MCM3 EXOC4 SSBP1 RNH1 C18orf25 FBXO24 SND1 BLOC1S3 MLEC HSPA14 PTRH1 UBE2S TBC1D22A MBD1 MZF1 LMAN2 SLC35C1 ZMYND12 ARMC5 KLHDC4 RCCD1 NPRL2 DUS2 MOCS3 SCYL3 RAB11B-AS1 MRPL27 ANXA4 TIMM10 MYO9B RAB27A CCDC148 VRK3 ELAC2 AIMP1 DNM2 UBR1 GTPBP10 CDNF PTCD3 PDCL3 RPL23 GTF2H3 UBXN1 SMUG1 C6orf62 STAG3L5P SPAG7 RPN2 BAZ2A DCAF6 PSMC5 TMEM38A PEX1 LRRC29 MCM8 CLPTM1 C15orf41 APMAP TMEM160 ZNF837 TMEM260 ZNF622 COX8A APTX ZNF581 ZNF343 SLC39A9 AP2A1 PRSS16 RFWD3 NSUN3 DNAJC14 COPA SHKBP1 GATAD1 NAA25 TFCP2 NDUFS2 RBM42 SF3B5 ZMAT2 EIF3H CHFR PNPO COPE C19orf25 RABGEF1 TAF2 TAB3 BTF3L4 up
## RBM34_TARGET_GENES 0.0010267 0.0069322 0.4937067 2.507679 0 846 SUN1 PDXDC1 AURKAIP1 MRPL20 PDP1 RER1 EDC4 B3GALT6 JMJD8 ZNF398 E4F1 CABIN1 HMOX2 RNPS1 ASL SCMH1 USP39 PANK4 POLD2 SRRM2 MGAT4B KIAA1522 ADRM1 ACSS2 RPUSD1 TTLL12 AP001372.2 SDF4 FLYWCH2 GFER PRSS27 CTTN CCNL2 UBE3C LRWD1 SLC7A6 MYO6 ZNF174 FASTK NMRAL1 NBPF3 FAM207A AP3D1 KIAA0895 CAPN1 PPFIA3 LRRC45 KIF1B PTPRA C16orf70 PAXIP1 RFX2 FIBCD1 AVL9 MRPS2 DECR2 MBOAT1 ADAM15 STK11 APRT MIB2 TMEM259 NME4 SLC35A3 TP73-AS1 DHCR7 LIPT2 ARFGAP1 MVD PKM SPATA2L AHDC1 ZFP64 DNAJC5 KRI1 WRNIP1 EMC8 RUNDC1 WIZ ZNF786 LMF1 POLD3 PUM1 RRBP1 CHTF18 LONP1 TRMU PIEZO1 ZNF212 TNIP2 SNAPC4 DNMT1 PSMD11 NELFA TOR1B PARK7 PHRF1 PPP4C MAD2L2 TUBG1 RPL36 RAB40C SOX8 RANBP1 TMEM189 TIRAP HOXC-AS1 TMEM177 RMND5B PLCG1 TUBGCP5 SPG7 ANKRD11 LSM5 ZSCAN32 EPS8L2 TUBB2A SLC2A8 MORN1 GMEB2 ANXA11 CLCN7 PGAP2 BCKDK MOCOS RPL35 SF1 NAT9 ADAMTSL5 MKRN1 CHGB DDX55 HABP4 IRF7 ATIC YIPF2 CD55 CCAR2 CNNM3 TRIM28 DBNDD2 SLC7A5P1 GALNS ERF SQSTM1 EZR PANK2 FGFRL1 DGCR8 CHPF2 TMEM175 NAA40 SBNO2 MTFMT BRSK2 OGFOD3 ALKBH4 WDTC1 FHL2 CDON RPLP2 C19orf73 GATAD2A BRD7 EHD4 ZNF276 SF3B2 VAPB FOXK2 SOX12 TACC3 SLC38A10 VPS9D1 HMG20B NSFL1C SEMA4F PPP4R1L ANKRD16 FBXL16 CIZ1 TADA2B ALYREF CAPN12 MKNK2 IMMT LMNA YRDC PDCD6 LRRC59 MAP3K10 CLN6 TRIM45 HADH GAK RBM33 SLC35C2 SGSM3 LARP4B SMYD5 ASH1L MAN2C1 PRKDC SLC12A9 TRAPPC2L PROCA1 ZNF774 GPSM2 FRMD8 SLC25A10 NUDT1 USP20 MYH14 DBP TRMT2A MIOS ATG4D HNRNPUL1 P4HB CTBP2 QSOX1 ACTN4 EDF1 PPM1H RIC8A DPP9 KCNK5 CDS1 FANCA PPP2R5A SPIRE2 PYGO2 FARP2 POMT2 WDR83 BCL2L1 PRMT3 E2F1 TCIRG1 ZER1 TXNDC11 PCNT CDCA7 ERICH1 SMARCB1 PPARD SPPL2B HIBADH PDXDC2P CAMK2G C1orf216 ZNF778 CHID1 HTT PDIA4 PKMYT1 TRIM7 GIGYF2 SAMD4B WDR62 NF2 CRELD2 RAB11FIP1 SPRED1 FHDC1 CCDC57 TFAP2A UNKL SVIL CTSH CERS2 ETFB SPECC1L-ADORA2A GORASP2 CNOT11 POLE4 RN7SL525P STXBP1 NLRX1 PITRM1 BAHD1 RAB40B IMPDH1 C2orf68 MON1A RAB22A IDH3A MIR4449 DCXR RALGDS PHYH FANCE TRAPPC9 UCK1 AGPAT3 KIFC2 EEFSEC FAM131A TCF25 COX4I1 SNAPC2 FOXJ2 ABCB10 SAV1 DENND6B SLC8A2 CDKN2AIPNL PIN1 CIB2 SUCO ACOT7 LINC00482 TUBB4A SLC25A13 SCAP MAPKAPK3 TMEM129 ATP11A SURF2 TMEM104 MBTPS1 DAG1 PPARA C2CD2 RCCD1 ZBTB21 LSM7 TONSL HIRA TEF DHX30 XYLB ZNF77 WDR45B MTMR3 RPP38 GORASP1 KDM4B TAZ LZTS2 DRG1 NETO2 PTPN18 ACADS GALK1 SLC1A5 TMEM39B NOD1 PLOD1 CCDC12 ANAPC11 ZNF425 SPIRE1 ACTR3C ARPC5L TMCO1 BHLHE40 PLLP HDDC3 STRIP2 BMP8B MPZL1 STXBP2 TUBB4B TECPR1 SLC25A43 CRKL FPGS ACTR1B KAZALD1 APMAP NEK9 RNASEH2C RPA1 TMEM106B NNT-AS1 WFS1 NBEAL2 ZNF837 FZD5 PACS1 MRPL34 PLEKHF1 TSC22D2 BICD2 TOR2A NDUFAF6 KIF1C ZNF18 NUP98 C21orf58 GLRX3 P4HA2 AMACR SMYD4 CTSA NECAB3 MRPS28 ALAD AFF4 HNRNPU GPR3 ZNF558 ZNF775 HSD11B1L REEP4 IER5L C15orf39 ANK1 ARPC1B ZSWIM7 NDE1 ACTL6B SENP5 POLA1 KPNB1 FADS3 STX16 SLC35F2 LRRC27 DPH7 up
## GABP_B 0.0011494 0.0069322 0.5311647 2.494447 0 249 NOC2L EDC4 TBX6 RNPS1 ASPHD1 VPS53 CD2BP2 PPME1 SF3B3 COG4 TMUB1 CHERP STK35 LRRC41 DIS3L2 RHOT2 ZDHHC5 ZNF384 PHLDB3 LSR PCGF1 DNTTIP1 SEZ6L2 GTF2A2 DTX2 MAD2L1BP CHPF SCAMP2 PIGO C9orf40 RANBP1 DDOST LSM5 KXD1 CPSF7 EPN1 KLHL17 FIBP EBNA1BP2 TMEM208 USB1 CIAO1 PDZD11 NAA60 ACIN1 GNB2 ZNF485 DDIT3 RAB11B AGL FAM219A HERPUD2 CLDN12 TAF5L EIF1AD SLC38A10 U2AF2 TAF10 RPL32 CELF1 PATZ1 PLA2G4D SNIP1 TOMM40 TOMM22 SUPT16H USE1 PCED1A ZNF687 BCAT2 ZNF394 TRMT2A B3GAT3 HARS2 VPS16 DIAPH1 SYT5 ZSCAN20 CRB3 SUPT5H CPT2 PER2 CCDC85B TMEM127 SF3A1 GALNT10 TRIM44 CSAD PHF23 ZNF79 PRKAB1 MON1B UQCRH C12orf66 C12orf10 RPL34 NMNAT1 MLEC DLX4 CCZ1B CLMN MPZL3 RPS6KA3 TMX1 KAT5 MOCS3 RSPRY1 SRP54 BANF1 SART3 GNL3L SDHAF2 MYO19 TMCO1 up
## ZC3H11A_TARGET_GENES 0.0010299 0.0069322 0.4918142 2.494416 0 811 ISG15 SSU72 RERE VPS13D AURKAIP1 MRPL20 EDC4 TBX6 ZDHHC4 PHACTR4 TBL3 SNX18 AMBRA1 MLST8 WDR24 PANK4 HMGA1 MRPS34 BSDC1 FBXO34 ADRM1 INTS5 TMEM222 BMS1 ZNF408 FEM1A ZNF768 YTHDF2 CHMP1A MCAT LRWD1 IPO4 GDF15 PPP1R37 IGHMBP2 NOC4L LINC00853 CLK3 FAM207A TUFM HES4 CWC25 MRPL55 SPATA33 INTS1 FBXO2 KAT8 KCTD5 GTPBP3 SPATA20 INO80B TRADD CDK11A MKRN3 TRIP4 SNRNP200 PTPRU PSMG3 TNRC18 CROCCP3 HMGXB3 KMT2C TMEM259 CHD2 NDUFB10 GEMIN4 SRRT MST1P2 TMEM63A ZBTB45 EME2 SLC35A3 THOC6 ILDR1 CROCCP2 NOL6 DDX51 SLC27A5 ZNF786 GPR137 EVA1C NSUN4 MRPL49 PPP6R1 DTX2 TRMU DUS1L GDPD5 NLE1 CLTB VPS51 ZNF746 PSMD11 ZNF205 TOR1B ATP13A4 DGCR2 BRAF VPS37B MAPK8IP3 SART1 TRPC4AP SDC4 LPIN3 RPL36 RAB40C AGK PRDX5 ZNF76 COPS7B RNF216 GGA3 ARHGAP1 LSM5 ARF1 XPNPEP3 TIGD1 HUS1 ERI1 TNPO3 KLHL17 CA11 RFXANK DDX55 SH2B1 YIPF2 SSR4P1 CCAR2 SHARPIN USB1 CIAO1 UBTF EP400 DAGLB ACACA REV1 ZNF74 PIGG DGCR8 CLDN23 ZMYND8 KLHL20 GOLGA3 CYP4A22-AS1 RTEL1 CSNK1A1 STX18 MTFMT TRMT112 ALKBH4 ZMPSTE24 FBXO22 ILF3 CFTR DDIT3 NR1H2 RAB11B ZNF276 PAK1 SF3A3 FAU JMJD4 MARK4 CASD1 EIF1AD MRPL24 VPS9D1 PVT1 TRMT44 EXOC7 C12orf76 UBE2H NDUFS3 RFX1 RNF187 SCAND1 GAS8 KIF22 PRPF18 STX4 HSD3B7 DMTN RBBP5 B4GALT7 MKNK2 EI24 NELFB NFAT5 PDCD6 GAK SMG7 ZC3H4 EXOSC2 MIR3189 SLC39A3 MAN2C1 TIMM9 CTNNA2 EMC10 PRAME RNU6-1340P MAZ STOML2 RPS20 TAF1C SPATS2L FAM98C TXN2 DHX33 PPIL2 AAR2 B3GAT3 POLR3B COMTD1 GNAZ DRAP1 MPHOSPH10 DIAPH1 ZNF341 ZC3H3 NOXA1 NKAP ACSF3 ZER1 SUPT5H HCFC1R1 PI4KA PPARD SLC25A16 MADCAM1 SNAP47 PARP12 SLC37A3 NEAT1 TMEM127 VPS25 NYAP1 TARS2 CPSF4 PRKCSH C17orf75 MVK C9orf163 GBA C11orf49 PDE4A LTK NOSIP CDK5RAP3 HINT3 SLC20A2 CCDC57 PHKA2 AKAP9 FBXO28 DHRS13 PSMF1 PRRG2 BECN1 NPAS1 RPL37 NUP214 NPLOC4 DPM2 MAP4K5 TSEN54 KEAP1 KIAA0586 RBM28 CPNE7 RPS7 SON SSBP4 BANP PSME3 FAM71E1 MPLKIP CYTH2 PFAS DNAJC2 SAR1B TYK2 JOSD2 PCF11 MRPL21 EIF2B4 SSBP1 EEFSEC TMEM82 GART PPIA GTF3C5 CLUAP1 PLEKHG5 HOMER1 UTP3 MLEC PINK1 CDKN2AIPNL NFKBIB COQ4 ETV4 TACO1 MED15 SAFB2 TOP3B ATMIN AIG1 NUDT8 ZBTB21 FBXW8 RTEL1-TNFRSF6B DUS2 HIRA RRP15 WDR45B ALDOA TUT1 BANF1 SAE1 LRRC37A3 CHMP2A GNL3L CCDC88B MAF1 PARP1 CLASP1 NR1H3 CCDC12 NOL12 CCDC106 VPS13C TSPAN10 BHLHE40 NDUFS7 RNF168 CASP2 AGMAT HPCAL1 SLC37A4 NME1 TMEM101 DMAP1 GEMIN5 C6orf62 TIGD6 COA6 DHX8 NDUFC2 DDR1 CRKL TTC26 FBXW5 ATPAF1 SDHAF1 R3HCC1 PTCD1 GLG1 SAFB NBEAL2 SBDSP1 DHTKD1 SLFN12 CTNNB1 SLC30A1 PLK3 FAM222A KIAA0100 TMEM41A ZNF581 TRUB2 ZC3HC1 NUP107 KDM3B RTN4R ZNF385A PSMC2 JARID2 up
## NPAT_TARGET_GENES 0.0012077 0.0069322 0.5392497 2.473804 0 204 DNAJA3 ZNF12 FADD MLST8 TOLLIP-AS1 ZBTB17 SMARCA4 AP001372.2 SNORA14B NPRL3 PHF12 RFX2 SAYSD1 ZDHHC5 FAM220A FBRS MST1P2 CROCCP2 LIPT2 SMG5 POLD3 LONP1 PPP6R1 VPS51 ENTPD6 RPL36 RANBP1 CEP250 RRP1 ATP6V0E2 IQCC BLOC1S4 DAGLB CSNK1A1 NUP93 ATP6V0E2-AS1 MAN1B1 VAPB ARMC6 JMJD4 SRRM5 SIN3B NVL CDK12 EHMT1 CD320 MOK MCRS1 DPF2 EMC10 SIRT6 TRMT2A FAM222B THAP7 ANKRD24 EXOC8 TIMM13 TOLLIP SUGP2 SPPL2B SNAP47 SEC61G RPRD2 ZBTB40 RPL27 PHF23 TOMM20 KHDRBS1 MIS18A KIF3B SAMD1 CHCHD4 FAM71E1 RAB35 SPRTN HMGB3P22 NBPF1 PAGR1 HINT1 FXR2 SMAD5 RNF19B SNX1 LSM7 RPP38 VRK3 CCDC12 CISD1 TMEM79 PREB RBM17 GLG1 CDC42EP4 VPS26B PRELID2 THOC3 NDUFA11 THAP7-AS1 POLA2 ZNF576 LRRC27 VMAC WDR43 TMEM141 PDRG1 COPS7A HNRNPA1 RMND1 RANBP3 TK2 HINFP STK32C SLC2A11 ASPSCR1 CKLF-CMTM1 CXorf38 PRPF40B MTCH2 YEATS4 PVR TMEM43 MRPL45P2 EIF3E FAM24B CCDC7 ANKRD26 BNIP3 up
## ZNF711_TARGET_GENES 0.0010060 0.0069322 0.4771335 2.467987 0 1465 SSU72 CDK13 SUN1 NUDCD3 E2F4 AURKAIP1 FBXO42 EDC4 ZDHHC4 TMEM248 EIF3B TRAF7 OTUB1 ZNF12 ZNF398 PSMC6 UBE2J2 MLST8 SRRM1 MTOR TBRG4 TAF4 WDR24 PANK4 POLD2 SRRM2 MNAT1 SLTM DDX19A SNHG3 URGCP INTS5 GPN2 BMS1 ZNF408 SMARCA4 BAD C1orf122 ZNF3 AP001372.2 MARK2 PPP1R35 UBE2I YTHDF2 PPP1R9A UBE3C SNORA14B RCC1 LSG1 SF3B3 TAF6 SLC7A6 IPO4 AKAP1 ZNF174 FASTK IGHMBP2 COG4 WWP2 GNAS CLK3 TSR3 FAM207A TUFM CWC25 MRPL55 KIAA0895 SRCAP ZKSCAN2 USP42 CDK5 TULP3 KCTD5 GTPBP3 SLC2A4RG PAXIP1 STK35 AVL9 INO80B SF3A2 MRPS2 MKRN3 MGRN1 TRIP4 SS18L1 ERI3 PSMG3 PHLDA3 MRPS15 USP54 TNRC18 ZXDC ZNF362 ERV3-1 ZGPAT HMGXB3 RPS5 DPP3 CREBZF ZNF496 TRMT1 METTL16 LGALS3BP GEMIN4 SRRT SLC37A1 MST1P2 EPS8 PIGQ ZBTB45 PSMD3 JTB DNPEP SLC35A3 MAGI2 CROCCP2 LIPT2 CHD8 SMG5 CYP51A1 ZFP64 NAPEPLD SNX8 RPTOR SZRD1 SLC27A5 ZNF786 GPR137 GNPTG POLD3 RILPL1 ZNFX1 DDX19B WDR73 TRMU DUS1L CHCHD3 CTBP1 HLCS BRD9 ANKFY1 VPS51 RN7SL1 ZNF205 RNF10 ATP13A4 TMEM62 SCAF1 CHPF PYCR2 NGDN TMED4 PARK7 PHRF1 ZNF592 TSTA3 MANEAL CCDC47 AGK MRPL48 RANBP1 FAM120AOS PPM1A STIP1 COPS7B ABCB8 BRD4 ZNF319 C1orf53 ARHGAP1 TUBGCP5 SPG7 ANKRD11 LSM5 ETFA PRCC PI4KB TARDBP MAP2K2 ZSCAN32 AP1S1 NOL9 MUL1 RNF4 CPSF7 TIGD1 DHRS7 SLC2A8 ARFRP1 RPL12 SCYL1 HUS1 ATG2A ARFGEF2 TNPO3 BCKDK ZNF213 GPBP1L1 NDUFB2 ZNF32 SNRPB RFXANK RPL29 DDX55 SH2B1 KLHDC2 ATIC PSMA7 CCAR2 SNORD60 SHARPIN ZNRF2P2 HDGF CLTA USB1 TM9SF1 RPL22 UBAP2L NAA60 LAS1L PIGG DGCR8 NCL ZMYND8 KLHL20 GOLGA3 RTEL1 ACBD6 TAF12 IFT57 STX18 ZSCAN25 RPL3 ATP9A OGFOD3 THAP3 ZMPSTE24 RBAK FBXO22 PTRHD1 ARID4B SLC25A51 CA13 RPLP2 NMT1 PLEKHJ1 KLC2 TMEM203 RUVBL1 NR1H2 B4GALT5 RANBP17 ZNF862 CPNE1 ANKMY1 ZNF276 SF3B2 GOLGB1 ECE2 HERPUD2 SF3A3 ZBTB7A MGME1 JMJD4 FOXK2 MARK4 CASD1 CCDC40 SH3YL1 CHCHD2 TSR1 EIF1AD MRPL24 KHNYN VPS9D1 ABR TCERG1 CDK12 C12orf76 RPL32 CELF1 RFX1 RNF187 NSFL1C PEX13 PPP4R1L GAS8 CDC5L HSPA9 RPS11 SFSWAP RELL2 DVL3 EIF4G1 SNORD46 CIZ1 TXNL4A DMTN RBBP5 B4GALT7 ALG10B IMP4 EEF1D BOD1 ARHGEF11 CLPX MAP3K10 ERI2 POLG SMG7 RBM33 SUPT16H FAM76A ZC3H4 LEMD2 NAE1 DUSP28 HECTD1 C16orf58 MAN2C1 TIMM9 RNF19A PSMA3 RETSAT PSPH TRIM52 PROCA1 ZNF774 USP7 MRPL4 PPP4R1 NCOA7 POU3F2 TRMT2A PAIP1 STK16 STOML2 PLEKHA8 CIAPIN1 TXN2 HNRNPUL1 DHX33 ZNF689 CDK5RAP1 ZFAS1 CBX1 EDF1 MRPL12 PPAN MT-TP MCM3AP GPD1L MPHOSPH10 RPL37A MT-ND2 SMARCD2 ZC3H3 WDR83 ZNF785 BCL2L1 ESF1 PHF5A EXOC8 NOXA1 NKAP ACSF3 ZER1 SNX19 FAM120A ATG14 HDLBP CDCA7 RPS27 PIH1D1 FDPS C16orf72 MADCAM1 MRS2 RPL27A NCOA5 TOM1 SNAP47 TSN C1orf43 SPIDR DHX9 USF1 PTOV1 TARS2 UPF1 C17orf75 MVK PDIA4 C9orf163 TAPT1 PCGF3 C11orf49 BPTF COG1 RPL9 PPP2R5B DIS3L PDE4A NOSIP STEAP2-AS1 COQ9 SEC61G FBXO31 PMS2P3 UBE2Q1 CCDC57 XRRA1 MAML1 MRPL33 TGFBRAP1 AKAP9 UBE3A CRTC2 CDK4 PSMF1 PRRG2 SNX5 ALG3 NT5C NOA1 ZBTB8OS ING5 CERS2 RPL37 COA3 TOMM20 NUP214 NPLOC4 RHBDD3 MTR NUBP1 MT-TM TESK1 MAP4K5 SIL1 ZNF354B ELMOD3 KIAA0586 NT5C3A BAG5 RBM28 MON1A PPCS RPS7 HDAC4 SON BANP NRDE2 TRAPPC2 ZNF346 SURF4 MPLKIP SPRTN ZNF628 DNAJC2 SAR1B NUP133 EIF5B BCL2L2 GRSF1 LRSAM1 AGPAT3 FXN MRPL21 EIF2B4 GOSR1 SSBP1 EEFSEC TCF25 SNHG16 PTOV1-AS1 NBPF1 GART LINC01023 DTNB GTF3C5 CLUAP1 ZNF579 ATXN7 MAPKAPK5 TSSK3 LTBR UTP3 NMNAT1 DENND6B SCNM1 DTD1 PINK1 PIGV H6PD POLR2H COQ4 TBC1D16 RBM14-RBM4 MYEF2 SLC22A5 SMAD5 TACO1 UIMC1 MED15 ZMYND12 SPG11 TOP3B SLC5A6 ANKRD13D MIR191 PSMD2 SLC4A1AP MBTPS1 GPLD1 TMEM9 RCCD1 ANKRD46 C1QBP RPS23 SNRNP70 FAM133B SRD5A3-AS1 ARHGDIA HIRA RRP15 ARMC10 DHX30 PRDM15 EAPP RPL14 MRPL27 WDR45B RAD52 ANXA4 RPP38 TUT1 LARP1B BANF1 MTA3 SAE1 ZNF544 SLC30A5 RHNO1 DCAKD FOXM1 DRG1 GOLGA1 CCDC88B CCT6A SDHAF2 MAF1 LIMA1 LRP11 NRBP1 ORC5 GTPBP10 NR1H3 NOL12 RAD23B VPS72 PTCD3 TSPAN10 CDIP1 RBBP4 PDCL3 COPB1 TMCO1 ZFR NDUFS7 GGPS1 NDUFC1 CBLN3 CCT2 SOX6 NME1 TMEM101 DMAP1 CCDC97 TIGD6 SEPHS1 COA6 DCAF6 OFD1 YLPM1 TMEM79 RBM14 SNX27 LINC00552 TARBP2 NDUFC2 AKT1S1 RPL23A TSSC4 TTC26 ATPAF1 RINT1 EEF1B2 BRF1 ILF2 TMEM209 RBM17 RLF ANKRD39 NNT-AS1 FAM3A TSEN2 PBLD PEG10 ZNF714 PABPN1 COMMD10 USP8 SLC25A11 MT-TF SUGP1 PTPMT1 TMEM41A NCK2 CCDC117 ZNF581 ABCC11 TMEM198 TRUB2 ZC3HC1 GPD2 SLC39A9 PDXK NUP107 DNMT3A RFWD3 PSMC2 ATP6V1E2 AFF4 EIF2D MAU2 MSH6 GSTA4 TBC1D17 NAIF1 ANKRA2 PEMT NFKBIZ OTUD7B TMEM214 ZNF337 NDUFAF3 SERP1 CHFR ATL1 ZNF446 USP40 SNAPIN FTO ITFG2 TMEM64 IPPK RNF167 TSPAN31 NGRN STX16 ASXL1 MTX2 RPS6 LRRC27 DPH7 up
## ZMYM2_TARGET_GENES 0.0013004 0.0069322 0.5743271 2.465420 0 115 GET4 EIF4G3 RN7SL3 ADRM1 MARK2 ZNHIT2 GDF15 MLLT1 STK35 NR6A1 ICMT RCOR2 CREBBP LINC00337 WRNIP1 PPP1R14B FAF2 AHCY PPP4C DAP3 MIDN CHMP6 SHARPIN RAC1 SKI DAP RFX1 RPS14 BCAR1 YY1AP1 EEF1D TJP3 ZC3H4 DOT1L RNF19A SERINC2 CDH3 SMARCD2 HIBADH RPL28 PPP1R13L PCGF3 RAC3 GALNT10 PDE4A TIGD5 NLRX1 HAUS8 PFAS PPIA VEPH1 NEMF TMCO3 MPST SAE1 MYO9B MAF1 TST GAMT FBXW5 AP2A2 CD3EAP PRDX2 MTA2 PDE4C CDYL RPS6 LRRC27 C8G CENPN BRAP LFNG RHEB ERCC4 ADPRHL1 STEAP1B RNU6-1 EPB41L4A-AS1 PPIB SAMD15 TDRD7 CDC25B up
## KAT5_TARGET_GENES 0.0010309 0.0069322 0.4849683 2.457312 0 768 C16orf91 MRPL20 DIDO1 THRAP3 SLC4A2 TBL3 RNPS1 HMGA1 CLUH POLD2 MAPKBP1 DDX19A SNHG12 FBXO34 TRNAU1AP BMS1 C1orf122 GID8 ZNF3 AP001372.2 PMS2 UBE2I YDJC SNORA14B FNBP4 ZNF598 RPL13 ISG20L2 PES1 SRCAP ZKSCAN2 PPFIA3 USP42 CDK5 PUS7 GTPBP3 PHF12 ATXN2L LRRC41 EARS2 AIMP2 PTBP1 IDH3B MRPS15 USP54 UBAP2 APRT ZGPAT PLAGL2 CREBZF WDR60 CENPT EEF2K CHD2 PHF14 MST1P2 JTB CROCCP2 MDN1 LIPT2 RRNAD1 PRMT1 NSUN2 NELFCD NAPEPLD GPR137 POLD3 DUS3L PIGU MT-CO3 NLE1 TNIP2 UBIAD1 RN7SL1 NELFA SIPA1L3 RALGAPA1 SCAF1 DGCR2 SLC35B2 TMED4 DDX31 HOOK2 SART1 RSL1D1 RPL36 CCDC47 MT-ND3 UBFD1 RANBP1 RPL10A C1orf53 NXT1 RPSA ARID4A PRCC SNHG7 RTF1 RPL18A CPSF7 GIT1 ARFRP1 LRRC14 MTX1 C22orf46 ZNF692 GLOD4 PNPT1 VPS9D1-AS1 ZNF839 SF1 SNRPB ZNF239 NAT9 PRMT5 DDX56 SNAPC5 DDX55 MAP2K7 TMEM208 RANGAP1 HDGF RBM12B TM9SF1 AP2B1 RPL22 PPM1G UBAP2L KLF16 ACACA NOLC1 GNB2 PELP1 RABGGTA TAF12 RPLP2 RPS15 GADD45GIP1 MAPK8IP2 LGALS8 MGME1 MARK4 TSR1 TACC3 EIF1AD AMPD2 MRPL11 VPS9D1 PYCR1 RPL32 RPS14 RAD23A HSPA9 PPRC1 METTL1 POLR2E TXNL4A PUS1 CHCHD10 NFAT5 LZTR1 TOMM40 MRPS35 EIF3G POLG LARP1 RBM33 GTPBP4 USE1 UBE4A DPH1 TRIM52 MTND5P11 ZNF202 CTDP1 MRPL4 USP20 DBP TRMT2A JKAMP RPS20 HAX1 THBS3 PLK1 SLBP COMTD1 STRADB PPAN DPP9 HSP90AB1 RPS29 DIAPH1 RPL37A TIMM8B TXNDC12 ZNF785 SUPT5H HCFC1R1 HDLBP ERICH1 ACAD9 TP53 NCOA5 XPOT RPL19 TSN MRFAP1L1 NEAT1 C1orf43 ATAD2 DHX9 PSMC4 MRFAP1 L3HYPDH C17orf75 RRP12 RAD51D NRL ASNS NOSIP UBXN6 NFE2L1 TIMM22 HINT3 PGBD4 ZNF444 DHRS13 RPL27 PRRG2 SNX5 BECN1 ING5 SLC3A2 DDX42 POLE4 SIL1 RBM28 RNF7 RGL4 UQCRH GLO1 STAG3L5P-PVRIG2P-PILRB C12orf66 ZNF574 PSME3 C2CD2L ARF6 DCXR PFAS RPL34 KDM2A SAR1B XIST HMGB3P22 DCAF11 LRRC8B S100PBP PCF11 EIF2B4 MEF2D GOSR1 GTF3C4 F12 PPIA AEN SNRPE UBE2S DTD1 MFSD3 SRPRB MED15 C17orf100 CERS6 TMEM129 ERCC1 SFT2D2 UBE2T TMEM104 TOP1 RCCD1 RPS23 ARHGDIA PRDM15 SARS2 PPDPF TIMM10 BANF1 TAZ POLR2A MORF4L2 GNL3L SDHAF2 SRD5A1 PARP1 MRPS12 MAP3K14 SPOCD1 SPRYD4 RNF123 RAD23B VPS72 PPIH ARPC5L UMPS WDR87 NDUFS7 ZNF131 PFKP PA2G4 CCT2 DNPH1 NME1 DMAP1 UFC1 C6orf62 STAG3L5P SPAG7 PITPNA YLPM1 TRA2A TAGLN2 MALAT1 RPL23A LRRC29 FPGS FBXW5 RINT1 EEF1B2 ILF2 LSS HNRNPF AP2A2 RBM17 UBC SFPQ DPAGT1 DHX15 MRPL34 DESI2 ULBP1 NDUFA2 COX10-AS1 MCM2 VPS26B BAP1 ATP6V1E2 EIF2D ZNF558 PEMT HSD11B1L EZH2 SLC9B2 CHFR G6PC3 NPW CBX3 IMMP2L POLA2 BTF3L4 KPNB1 RPS6 SLC35F2 DIP2A RPL5 C8G MTHFS RNF145 GALK2 SENP2 WDR43 up
## HJURP_TARGET_GENES 0.0013850 0.0069322 0.6487372 2.448468 0 51 RPPH1 MT-TN MT-TC PHF14 MT-CYB MT-TV CRY2 VPS37B DEAF1 MT-ND3 SDHA MT-ND4L CCDC127 RPL3 MT-ND5 PARP2 MT-TT MT-ND4 NCOA7 MT-ND6 MT-TH MT-TP SPTAN1 MT-TS2 WDR4 CCT3 RPS15A IFRD1 TUBB4B MALAT1 ILF2 MT-TF up
## DIDO1_TARGET_GENES 0.0010070 0.0069322 0.4737974 2.447315 0 1381 SSU72 C16orf91 NUDCD3 ATAD3A DNAJC16 MRPL20 RER1 EDC4 ATAD3B TMEM248 CDK11B TBL3 MFN2 AMBRA1 ZNF629 DHDDS HMOX2 TELO2 MTOR WDR24 PANK4 STARD10 MRPS34 CCDC86 MNAT1 INTS5 ZBTB17 BMS1 ZNF408 BAD ZNF3 FEM1A UBE2I SPATA2 CCNL2 FAF1 LSG1 MCAT IPO4 SLC35E1 PPP1R37 CXorf56 NMRAL1 EDC3 NOC4L WWP2 CLK3 ADPRHL2 GUSB FAM207A ZNF830 CWC25 PES1 MRPL55 ZKSCAN2 MORC2 INTS1 FAM118B COASY SLC7A6OS KCTD5 GTPBP3 ATXN2L ABCF2 INO80B MKRN3 MGRN1 FBXL18 IDH3B RPLP0 TRIP4 ERI3 NOP14 PSMG3 MRPS15 GBAP1 GNG4 CCDC159 C1orf35 ZGPAT HMGXB3 PEX16 ASB6 HAGH ZDHHC5 ZC3H18 SLC9A1 FAM220A PEF1 PSMD3 EME2 SLC35A3 CHD8 SMG5 AUP1 NUTM1 NSUN2 UFSP1 PEX14 UQCC1 DDX51 RPTOR SLC27A5 GPR137 POLD3 PRMT7 RPUSD2 PPP1R12C TRMU ZNF212 DFFA RPS3 EIF2B5 ANKFY1 CACTIN VPS51 NELFA ZNF205 ALG1 VPS41 TOR1B PIGT ATP13A4 PRR14 NGDN DDX31 SDHB SLC35B1 HOOK2 AHCY C7orf50 SART1 TRPC4AP BPNT1 MEN1 AAMP RPL36 PSMC3 RRN3 HPS4 ZNF263 TUBGCP6 MRPL48 COPS7B RNPC3 ABCB8 RNF216 FARSA AP4M1 ARHGAP1 TNPO2 TARDBP MACC1 COMMD4 BNIP1 ANAPC2 BRMS1 FEN1 LINC00630 TIGD1 IQCC ARFRP1 RPL18 HUS1 ERI1 LUC7L FBXL12 YKT6 TNPO3 GLOD4 VAC14 DBNL TTC31 SNRPB KNOP1 SNAPC5 RPL29 DDX55 BLZF1 EBNA1BP2 TMEM208 YIPF2 CCAR2 SHARPIN POLR2J COX19 AP2B1 CSTF2 RANBP10 TIPIN MED19 UBAP2L AARS2 ADAR TOX4 LAS1L ST7-AS1 PIGG PALB2 DGCR8 SUCLG1 KLHL20 RABGGTA RPS28 GOLGA3 RTEL1 BBS5 ZDHHC7 ZDHHC16 GPATCH4 STX18 BRPF1 ZSCAN25 SZT2 MED8 NDOR1 TFIP11 LONP2 NUP205 TMEM203 RUVBL1 BRD7 ST7 FAHD1 RRP1B DYNC2H1 ZSCAN21 GOLGB1 ECE2 HERPUD2 SF3A3 JMJD4 CXXC1 SRRM5 MARK4 KCNH2 SIN3B NAT10 SNRPD3 EIF1AD NDUFV1 TRMT44 NVL CDK12 C12orf76 NDUFS3 DOHH CLASRP RNF187 NDUFB7 KATNB1 PEX13 PPP4R1L MRPL37 URB1 SCAND1 RPS14 ZNF335 SNHG11 STRIP1 SFSWAP PINX1 PRPF18 SNIP1 EHMT1 TJAP1 ZNF133 RBBP5 KMT2D ALG10B LINC00115 GUCD1 ERBB2 BOD1 FAM50B WDR25 TOMM22 MRPS35 CLPX LRRC59 NABP2 EIF3G CCDC124 SMG7 CAMK2D SUPT16H MCRS1 FBXW9 ANGPTL4 LEMD2 USE1 MALSU1 ZNF688 ZNF26 ACBD3 SLC39A3 MAN2C1 UBE4A RETSAT PRAME DPH1 MAP2K1 TRMT5 RMDN3 CTDP1 ZNF394 STK16 STOML2 RPS20 TSKU GAN TAF1C MRPS33 CIAPIN1 TXN2 SEC24C SNHG17 DHX33 ZNF689 CDK5RAP1 ECSIT AAR2 POLR3B STRADB SSNA1 HARS2 MPHOSPH10 DPM3 NCLN MED18 RPUSD4 TRMT6 ZNF317 GGA1 SMARCD2 FLAD1 WDR83 ZNF785 ESF1 PHF5A GDAP1 PRMT3 WDR4 NKAP ZER1 BMS1P1 POLR2C ATXN2 CDCA7 HEATR1 MZT2B DCTN5 ACAD9 SMPD4 SNAP47 TSN RECQL5 TMEM258 C1orf43 ATAD2 SPATA5L1 VPS25 ROMO1 TARS2 KLHL12 PRKCSH C17orf75 NME7 GBA CCT7 C11orf49 TMX2 RPL9 RPIA UBXN6 WDR62 NFE2L1 COQ9 HINT3 ATL2 UBE2Q1 TFAP2A WDR34 MRPL33 WDR77 FBXO28 ZBTB40 PSMF1 SNRNP35 ALG3 BECN1 ZBTB8OS RPL37 POLR2J3 CCDC142 SREK1 QTRT1 MZT2A GORASP2 MIS18A MRPL54 ELMOD3 MRPS23 RPA3 RBM28 TIGD4 RPS7 HDAC4 BANP NRDE2 ST7-OT4 PSME3 C2CD2L MPLKIP ZNF623 TRAPPC9 SAR1B NUP133 BCL2L2 EFTUD2 S100PBP EXOC4 FARS2 EEFSEC C18orf25 SAP30BP PGAP3 RPS26 SNRPE GTF3C5 CLUAP1 MANBAL MAPKAPK5 NMNAT1 ZSWIM8 MLEC NHP2 C1QL4 CDKN2AIPNL MCM7 METTL2B COQ4 LSM10 CCZ1B PITHD1 DNM1P35 LMAN2 TACO1 SCAP MED15 TOP3B DZANK1 PARGP1 TMEM205 MPZL3 SLC4A1AP INTS7 OPLAH FIZ1 KLHDC4 UTP20 RTEL1-TNFRSF6B KAT5 DUS2 HIRA RRP15 SCYL3 CHCHD1 COA1 XYLB MRPL27 SRP54 TIMM10 GPATCH3 BPGM TUT1 BANF1 RAD54L POLR2J4 POGZ WDR53 IFRD1 AIMP1 SRD5A1 MAF1 NUP85 GTPBP10 NR1H3 NOL12 VPS72 MAGOH BUD13 DPCD SNRPC UMPS RBBP4 TMCO1 PCCB NDUFS7 DHODH ZNF562 POLR3A ZNF131 GTF2H3 ARV1 GATM ANXA2 CCZ1 NME1 TSFM TMEM101 DMAP1 UFC1 RPL4 CCDC97 ZNF507 TIGD6 CKAP5 THTPA DNAJC1 TMEM79 SP8 APBA3 NDUFC2 LRRC29 TTC26 CASP9 WDR70 BRIX1 MCM8 IQCK CLPTM1 GEMIN6 SP2 KCTD2 FAM135A MMACHC GUSBP1 C19orf47 RLF UBC SRRD DPAGT1 NFS1 HARBI1 APTX CTNNB1 TAF3 TMED9 SUGP1 TTC13 TMEM41A CPNE2 ZNF484 FOXJ3 ZNF581 WSB1 RPS3A TMED1 PSMB3 TRUB2 ZC3HC1 LRP6 ATP2B4 SLC39A9 NUP107 NAA20 CSTF1 VPS26B METTL17 ADSL CTSA LINC00680 STAT6 EIF2D ZNF558 MAU2 METTL9 NAGPA PEMT TFCP2 COX7A2L ATR HSD11B1L CBFB RBM42 ZNF2 TSR2 SERP1 ZMAT2 EIF3H CHFR NDUFA11 MED24 up
## ETF_Q6 0.0013089 0.0069322 0.5693382 2.436061 0 112 RERE UBR4 MFN2 SRRM1 MTOR ZBTB17 TMEM222 PHF13 YTHDF2 FAF1 MRTO4 LRP8 KIAA2013 SLC41A1 POMGNT1 EMC1 MCU ZNF362 ZNF496 ARID1A KPNA6 PRDM16 LAD1 RUSC1 DAP3 EFNA3 CAMK1D CTNNBIP1 CLSTN1 XPR1 YY1AP1 CELSR2 RNF220 FAM76A MARCKSL1 ASH1L USP21 ZNF687 ATXN7L2 MAST2 HPCAL4 CAMK2G C1orf43 RPRD2 CRTC2 NFYC GNB1 SKIDA1 KDM1A ZSWIM8 AGO1 PITHD1 ST6GALNAC5 SCYL3 up
## KLF13_TARGET_GENES 0.0010040 0.0069322 0.4690065 2.435229 0 1766 ISG15 KIF16B NOP9 CDHR1 AURKAIP1 DNAJC11 ATAD3A MUTYH PEX10 EDC4 ATAD3B THRAP3 TBX6 GET4 SLC4A2 CARHSP1 PUSL1 MECR RNF121 CTU2 GSPT1 ZNF629 DHDDS SMIM1 AAGAB TELO2 ASL METRN USP39 KIAA0319L WRAP73 HMGA1 MRPS34 PRPF6 AXIN1 BSDC1 PGBD2 TXLNA NCDN POLR3E GPN2 TMEM222 ZNF408 RHBDF1 SMARCA4 PHF13 ZNF3 INPPL1 GAS5 VWA1 MARK2 TP53BP1 PPP1R35 FZR1 PMS2 UBE2I FBXL19 CHMP1A UBE3C TTC39A LSG1 TMEM201 TAF6 IPO4 DCUN1D5 UCKL1 PPP1R37 EIF6 ZNF598 SH2D3A ZNF174 EDC3 STUB1 CAPN15 CLK3 TSR3 TUFM HES4 KIAA2013 MRPL55 EXPH5 AP3D1 CHERP SRCAP EVI5L ZKSCAN2 CLPB MORC2 SPATA33 PPFIA3 LRRC45 LETM1 LIG3 C1orf159 CSNK1G2 LSM14B KCTD5 PHF12 ATXN2L LRRC41 ABCF2 EARS2 INO80B SF3A2 AIMP2 PTBP1 ANKS3 TRIP4 SNRNP200 ADAM15 PSMG3 DLG3 FOXO6 GBAP1 GNG4 C1orf35 ZNF646 APRT CLCNKB TMEM159 KMT2C HAGH ZC3H18 SLC9A1 ZNF384 CENPT EEF2K CMTR1 PEF1 ARID1A FRMD5 AGRN ADK DHCR7 NR1D1 CYP51A1 PRMT1 PELI2 DNAJC5 NXN KPTN NELFCD PIAS4 NAPEPLD CES2 MTFR1L ADNP2 RUNDC1 MICU1 ESYT2 GNPTG C16orf46 HSD17B6 GFPT1 ZNFX1 NSUN4 PPP6R1 CCDC137 XPO6 PPP1R14B PIEZO1 HPCA DFFA MAP3K6 NLE1 CLTB MLXIP TNIP2 BRD9 RABEP2 GCC1 ITPKA SIPA1L3 TOR1B SCAMP4 ATP13A4 SCAF1 CHPF HDAC1 VPS37B PTGES2 DDX31 MAPK8IP3 PHRF1 SART1 TRMT12 MAD2L2 BPNT1 GALNT11 RPL36 TMEM219 RRN3 HPS4 MNT TUBGCP6 CCDC47 BRAT1 ZDHHC9 AGK EMC9 UBFD1 RANBP1 PRDX5 SDHA TMEM150A ZNF76 COPS7B ZNF354A SAMD10 RRP1 AP4M1 ARHGAP1 TERF2 TMEM134 FBXL8 SNHG7 MAP2K2 ZSCAN32 PER3 CLNS1A BLCAP EPS8L2 NOL9 CPSF7 ZNF787 ANKRD36C ZNF500 SGSM2 TUBB2A ACAP3 LRRC14 SCYL1 HUS1 SMG1 KRT8 ERI1 LUC7L WDR59 FBXL12 TTLL11 BCKDK GPBP1L1 GLOD4 MIDN PMEPA1 RPL35 AHCYL1 VAC14 ZNF839 ZNF239 NAT9 ADAMTSL5 TPRG1L RFXANK SNAPC5 CHGB DDX55 TSC22D4 SH2B1 ATIC EBNA1BP2 CBX4 CCDC127 POLE CCAR2 CNNM3 ZNRF2P2 EFNA3 SUPT6H SLC25A39 RPL22 TIPIN C1QL1 NAA60 KLF16 RND2 NOLC1 REV1 USP35 B3GALNT2 DGCR8 NCL PELP1 MIER2 GOLGA3 TLCD1 TRIP10 STX18 BRPF1 TRMT112 ZMPSTE24 FBXO22 ILF3 NMT1 PLEKHJ1 KLC2 PDP2 BTBD9 RPS15 ATP6V0D1 RUVBL1 NR1H2 SLC12A7 CHMP4B USP10 FAHD1 SLC35E2B CAPN10 PDIK1L RRP1B DYNC2H1 ERGIC3 ZNF276 PFDN2 SEMA4B TRAF4 PNKP SF3A3 JMJD4 TAF5L OS9 AKAP8 KCNH2 SIN3B TSR1 EIF1AD NDUFV1 KANSL3 AMPD2 VPS9D1 CGB7 ZNRF3 EYA3 HMG20B C12orf76 CELF1 UBE2H NDUFS3 CLASRP NSFL1C MTMR12 SCAPER ILVBL PPP4R1L URB1 DHRS1 RAD23A PATZ1 HSPBP1 ZNF335 MED16 HSPA9 PAFAH2 SNHG11 ANKRD16 PAK4 SNORD46 VEZT CIZ1 TXNL4A STX4 EPB41L4B PTPN23 RBBP5 ALYREF PRKAR1B MKNK2 LINC00115 ZBTB42 EEF1D CDAN1 NELFB LMNA BOD1 MAP3K11 PISD CLPX KCTD21 TJP3 ADAT3 LMBR1 SMG7 UBALD1 MCRS1 LEMD2 NAE1 SMYD5 IGSF9 ETV3 SLC39A3 SLC39A11 CHAC1 SLC12A9 VPS18 CSNK1D PRAME DDX54 DPH1 NEK8 MAP2K1 FGD6 SIRT6 NCOA7 USP20 BCAT2 CHKA TMEM52 TRMT2A INPP5K PDE11A FAM98C HNRNPUL1 HAX1 ZNF689 CTBP2 ZFAS1 ZNRF2 URB2 B3GAT3 POLR3B RNF24 PSMB10 DPP9 VAMP8 DRAP1 YWHAG MPHOSPH10 DIAPH1 ZNF668 GGA1 ANKRD24 TMEM191A UTP18 HMGCL TXNDC12 TIGD2 NOXA1 DHX34 ACSF3 ZER1 ARHGAP33 RHOBTB3 SLC27A1 ZNF784 PCNT ATXN2 HEATR1 LINC00881 VGF DAZAP1 LRP2BP APLP2 SUGP2 PI4KA PPARD MADCAM1 SPPL2B GOLGA2 SNAP47 CREB3L1 PARP12 TSN ATAD2 CHID1 TFAP4 PTOV1 VPS25 ROMO1 NYAP1 AACS NAPB C17orf75 HEXIM1 HTT C9orf163 PPP1R13L CCDC107 PXMP2 GBA KDM6B BPTF NIT1 LTK ASNS NOSIP SAMD4B COPS6 TOP1MT CDK5RAP3 WEE1 DSTN TIMM22 MRPS6 PFKFB3 FBXO31 SPRED1 NEURL4 UBE2Q1 EFCAB14 TIGD5 WDR34 GRIN1 C15orf61 PHKA2 WDR77 ZBTB40 TIPARP UBE3A ISOC1 NUP160 CDK4 DHRS13 PSMF1 PRRG2 UNKL MYL6B BPHL CAMSAP1 RPS8 MAN2A2 ZNF414 POLD1 NPLOC4 CCDC136 MYH9 HECTD4 NUBP1 TESK1 CASC4 KHDRBS1 TSEN54 KEAP1 NT5C3A BAG5 RBM28 LIG1 TIMM50 HIVEP3 MON1A CD46 IDH3A UQCRH RPS7 HDAC4 SAMD1 ARHGAP40 CHCHD4 CDC14B PRKAA1 GNB1 CCNF RAB4A STOML1 RALGDS SURF4 HAUS8 AUNIP MPLKIP DGCR6L AGO2 TOR4A NIPA2 FOXL1 ZNF628 AJUBA UBA1 DNAJC2 TMEM87A GANC TYK2 KLHL36 CKB LRRC8B KRT18 PRKCZ MEF2D RNH1 RAB24 RNU6-9 GTF3C4 EEFSEC FAM131A PAK1IP1 KDM1A CIC NBPF1 TCEA2 TIMELESS PTDSS2 CLUAP1 ZNF703 RPL8 NMNAT1 SCNM1 DTD1 C1QL4 SLC8A2 PINK1 MCM7 TAF6L H6PD METTL2B NFKBIB SMPD2 MFSD3 LSM10 MTHFD1L CIB2 PAFAH1B3 ACOT7 AGO1 ASPH TIPRL UBE2L3 MFSD12 SCAP TOP3B BCL7C WDYHV1 MAPKAPK3 MXRA8 FOSL1 SFT2D2 UBA52 TMEM104 FANCG OPLAH CPAMD8 SUMO3 ANKRD46 LSM7 ZFP62 FBXW8 ZNF497 FOXN4 RTEL1-TNFRSF6B TMEM125 FAM133B HIRA RRP15 TCF3 CA5BP1 XYLB SLC35F5 SRP54 PSMD13 ANKS1A BANF1 MYO9B RAD54L NPHS1 MORF4L2 TMEM102 DCAKD LRRC37A3 NIPSNAP1 VRK3 SDHAF2 WDR53 ACADS LIMA1 GPX4 PARP1 GNE SPOCD1 ARHGEF18 TBC1D14 SPRYD4 GTPBP10 PXN ANAPC11 CCDC106 RNF123 TSPAN10 ARPC5L PDCL3 CLDN6 WDR87 PLLP GIPR RPL23 LYAR ARV1 CHCHD6 PCOLCE-AS1 ZMYM1 NME1 DMAP1 CAMKK1 G0S2 STAG3L5P SPAG7 CCDC97 DUT FAM185A SEPHS1 TUBB4B BAZ2A DNAJC1 MSTO1 SNX27 BFSP1 AKT1S1 RPL23A RRP8 FBXW5 NDUFA10 CLPTM1 LRFN4 ATP8B2 TBCB CYP2E1 COX7C ABCC10 HNRNPF MMACHC GUSBP1 MTCH1 YAP1 SRRD PBLD ZFPL1 MAST1 HNRNPLL PRRC1 HLTF ELK1 CECR2 TNFRSF21 CTNNB1 PLK3 ATXN1L TTC13 SIRT3 PPP1R3D PLCH2 ULBP1 CASP6 TMEM41A NDUFAF6 ZNF581 CD3EAP RPS3A TMEM198 C21orf58 LRP6 COX10-AS1 PDXK CAMTA1 LINC00896 JRKL KDM3B CTSA PSMC2 ALAD HNRNPU CRTC1 EIF2D ZBTB49 MSH6 ZNF775 TBC1D17 PRELID2 METTL9 ANKRA2 C11orf24 FANCC PEMT NEURL3 EZH2 PDE4C C15orf39 SQLE ZC3H11A GRK6 NDUFA11 NPW LASP1 EML2 PLIN3 CBX3 CACNB3 BTF3L4 POLA1 POLR2I NGRN FADS3 STX16 SLC35F2 LRRC27 VMAC MAPK6 DIP2A ACY1 RPL5 IQCH CUL7 C8G MTHFS FBXO33 RNF145 PGPEP1 DYNLT1 SWI5 TBCD ZBTB12 TSC1 up
## JDP2_TARGET_GENES 0.0010030 0.0069322 0.4680360 2.432019 0 1661 ISG15 TYW1 SSU72 RERE SPEN C16orf91 SUN1 NUDCD3 ATAD3A MRPL20 PDP1 ACD DIDO1 DNAJA3 RER1 UBR4 PEX10 ZDHHC4 CDK11B ZNF12 TRAPPC3 UBE4B NOB1 PUSL1 TBL3 MFN2 SNX18 CABIN1 DHDDS MRGBP UBE2J2 FADD YTHDF1 TELO2 PARD6A GTF3C1 USP39 KIAA0319L KCTD13 NUMA1 CLUH PRPF6 MAPKBP1 DDX19A TOLLIP-AS1 FBXO34 SNHG3 CC2D1B EIF4G3 NCDN POLR3E PPFIA1 TRNAU1AP ADRM1 TMEM222 AKR7A2 UXS1 C1orf122 GID8 PHF13 ZNF3 TTLL12 PLCB3 DDI2 PPP1R35 FZR1 GFER FBXL19 CCNL2 FAF1 SNORA14B RCC1 LSG1 STK40 ZBED4 LRWD1 TMEM201 IPO4 EIF2AK1 ZNHIT2 AKAP1 GDF15 UCKL1 KIAA0556 TAOK2 NUTF2 NOC4L CDC34 GNAS CNNM4 ADPRHL2 EXOSC10 REXO1 HES4 MRPL55 AP3D1 CHERP FLVCR1 MAP3K9 PPFIA3 LETM1 C1orf159 PUS7 WIPI2 FOXRED1 RFX2 BCL9L INO80B TIMM44 CDK11A RAD50 IDH3B XPO5 RHOT2 NARS2 SNRNP200 CIB1 ICMT MRPS15 ZXDC SLX4 MGA MTG2 ZNF747 PEX16 HAGH SLC9A1 REPIN1 WDR60 CENPT FAM220A CHD2 CCDC87 CMTR1 SIGIRR ACOT8 DNTTIP1 PSMD3 MEX3D ABCF3 CREBBP CHD8 LINC00337 SMG5 MVD PELI2 ENO1 DNAJC5 NELFCD PIAS4 NAPEPLD UQCC1 DDX51 WRNIP1 MRPL14 FGFBP3 TRIT1 TMED3 ESYT2 MEAF6 MRPL49 PPP6R1 XPO6 PPP1R12C HOXB9 WDR73 DCTPP1 CTBP1 DFFA POFUT2 MLXIP CACTIN VPS51 THOP1 ZNHIT1 MROH1 PLEKHH3 PIGT ATP13A4 MVB12A ENTPD6 MAPK8IP3 SDHB PARK7 SART1 TUBG1 AAMP RPL36 TMEM219 HPS4 MNT CCDC47 SBF1 RANBP1 SDHA PPM1A FAM86GP IFT140 RPL10A WDR18 RRP1 AP4M1 POLRMT SPG7 ANKRD11 LSM5 PRCC KXD1 ATP6V0E2 AP1S1 ARF1 HAUS5 ANAPC2 RSBN1L SLC22A18 ACAP3 NEIL2 RPL18 LRRC14 CLPTM1L MORN1 ARPC1A ERI1 PGAP2 WDR59 YKT6 NR2C2AP INTS4 SCAF4 TRIM11 HGS MRPL17 SF1 TMEM63B NAT9 CBX8 PRMT5 SPAG1 TPRG1L RFXANK SNAPC5 MAP2K7 BLZF1 ZSWIM3 CBX4 YIPF2 CCDC127 AGR2 BLOC1S4 CCAR2 RANGAP1 GDPGP1 PLOD3 HDGF TRIM28 AP2B1 CIAO1 PDXP RBM47 DNASE1 TPD52L2 UBTF RPL13A DDX23 DAGLB NOLC1 REV1 GNB2 PELP1 NOP56 RPS28 IRF2BPL MAGEF1 TMEM175 ATP13A1 RABL6 ZDHHC7 CSNK1A1 RAC1 STX18 RPL3 CDPF1 RNF213 OGFOD3 ALKBH4 ZMPSTE24 RBAK ARID4B SRSF1 RNF126 FAM13A PARP2 C1orf226 OSBP2 WDTC1 ILF3 ATP6V0E2-AS1 NUBPL DDIT3 NMT1 NR1H2 C19orf73 SRM GATAD2A RABIF CHMP4B USP10 FAHD1 PDIK1L CPNE1 XXYLT1 SKI ARMC6 TFB2M FAU ELL JMJD4 SRRM5 RCE1 CASD1 B3GNTL1 AKAP8 NAT10 FAM193A KANSL3 MRPL24 PRPF39 U2AF2 GRHL1 PYCR1 TRMT44 PTTG1IP CDK12 BSG NSFL1C CANT1 HDAC7 POP7 RRP7A EXOSC5 DNAJB2 MYPOP RAD23A ZNF335 KIF22 SNHG11 STRIP1 BCL6 SNORD46 EHMT1 PTPN23 ALYREF PDAP1 MOK UBN2 CUEDC1 EEF1D MED26 CDAN1 IMMT PARN RPL38 YRDC NFAT5 PDCD6 LRRC59 TRAP1 ERI2 CCDC124 SEC16A GAK LARP1 FITM2 LMBR1 SLC35C2 CAMK2D LARP4B NAE1 HNF4A TIMM9 USP21 RNF19A UBE4A PSMA3 RETSAT RNASEH1 CDCA4 RMDN3 SIRT6 SNORA37 PITPNA-AS1 DBP TRMT2A ARL16 INPP5K CCS MTHFSD SPATS2L MRPS33 GON4L TXN2 HAX1 P4HB KRT80 ACTN4 CBX1 CBX6 ZNRF2 RNF24 ENC1 MRPL12 SSNA1 DPP9 HSP90AB1 DRAP1 BCL2L14 SEC23B RPS29 FANCA TRMT6 GCDH SPTAN1 RPL37A MAST2 ANKRD24 DDA1 STT3A ZC3H3 IFT81 EXOC8 TIGD2 E2F1 WDR4 DHX34 SUPT5H TPR MLF2 ZNF784 CMIP PIGX ERICH1 MZT2B TOLLIP XRCC1 BOP1 ZFAND2B SUGP2 ACAD9 C16orf72 MADCAM1 SNX12 NCOA5 DYNLL2 SMPD4 TOM1 SNAP47 XPOT TSN RECQL5 RPS6KB2 NEAT1 BCL2L15 CHID1 TMEM127 USF1 PTOV1 ZFYVE27 SLC9A3R1 NAPB MED9 RRP12 PCGF3 NME7 C20orf27 GBA CCT5 ZNF865 ARMC7 RPL9 PPP2R5B WEE1 MRPS6 FBXO31 DYNC1H1 ZWINT PGBD4 DISP2 FNIP2 TIGD5 MMS19 TBCC ZBTB40 TIPARP PARD6B CDK4 RPL27 CNST ING5 PHF23 RPS8 TOMM20 NUP214 ZNF79 MYH9 HECTD4 PRKAB1 SPECC1L-ADORA2A SLC3A2 DDX42 CNOT11 RN7SL525P SIL1 STXBP1 KHDRBS1 MIS18A PITRM1 ELMOD3 KIAA0586 BAG5 MRPS23 RPA3 KIF3B RNF7 CRK CHCHD4 UBTD1 RAB4A STOML1 RALGDS ZNF217 SURF4 LIPE RAB35 SPRTN NIPA2 SH3GL1 PFAS KDM2A UBA1 SDR39U1 HMBS COPG1 HMGB3P22 KIFC2 S100PBP MCM3 MEF2D RAB24 RPS16 PAK1IP1 CIC MYO9A MKS1 SAP30BP ZNF536 SNAPC2 SCFD2 PLEKHG5 SAP130 DTYMK MAPKAPK5 TSSK3 RPL8 MGMT PAF1 SCNM1 DTD1 LDLR MBD1 MCM7 H6PD POLR2H MTHFD1L AGO1 PCNA SNX13 SMAD5 SCAP MED15 SAFB2 MIR191 PSMD2 ATMIN ARMC5 SLC4A1AP ERCC1 UBA52 TMEM104 INTS7 TOP1 SYNJ1 RPS6KA3 TMX1 ZBTB21 NPRL2 FBXW8 RPS23 SNRNP70 HOMEZ PPA1 MAP2K3 RPP38 SLC35F5 C12orf65 TUT1 LARP1B SAE1 WDR89 ULK1 DCAKD UBE2V2 NUP188 CHMP2A RAB3GAP2 WDR53 BUD31 LIMA1 SLC1A5 UTP6 DSN1 POLH ARHGEF18 ANAPC11 RNF123 RAD23B CNTROB MAGOH ATP2A2 RPL23 GTF2H3 GGPS1 PA2G4 CASP2 NDUFC1 CISD1 STX6 IER5 RPL4 CCDC97 DUSP10 IMPDH2 TEX264 OXA1L TMEM79 SEC61A1 SENP8 TK1 MALAT1 AKT1S1 ALKBH5 CCPG1 UBAC2-AS1 CRKL TSSC4 CASP9 BRIX1 MCM8 FBXW5 MIF4GD ACTR1B PREB ILF2 COX7C JUND LSS TBC1D10A AP2A2 TERF2IP MRPL36 RBM17 TTLL5 SRRD TSEN2 ZFPL1 MATN1-AS1 TMEM160 FAM177A1 SAFB DHTKD1 UBALD2 MYCN COX8A USP8 ATXN1L ZFP36L1 TMED9 TMUB2 INPP4A TAB1 TMEM41A BICD2 RBM12 MLLT3 PAICS CBR3-AS1 RPS3A NUP98 CCDC51 NUP107 WFDC3 ZHX3 NISCH TECPR2 ATP6V1E2 ZNF547 COPA MTA2 HNRNPU CRTC1 ZNF775 TBC1D17 METTL9 NAA25 CCAR1 up
## SETD1A_TARGET_GENES 0.0010081 0.0069322 0.4702120 2.425848 0 1272 TYW1 SSU72 RERE KIF16B USP18 NOP9 NAV2 CDK13 NOC2L NUDCD3 E2F4 AURKAIP1 DNAJC11 ATAD3A DIDO1 UBR4 MUTYH OTUB1 SLC4A2 TBL3 PSMC6 E4F1 AMBRA1 UBE2J2 MLST8 MTOR TBRG4 KIAA0319L MAPKBP1 BSDC1 NOM1 DDX19A SNHG3 NCDN TMEM222 ZNF408 CYB5B BAD GID8 FEM1A GAS5 UBE2I YTHDF2 EXOSC6 LSG1 STK40 SF3B3 SLC35E1 UCKL1 PPP1R37 DDRGK1 ZNF598 FASTK IGHMBP2 COG4 SPRED2 ADPRHL2 TUFM STAP2 REXO1 PES1 KIAA2013 SRCAP EVI5L CLPB ABCB9 SETD1A CDK5 METTL3 KAT8 C1orf159 KCTD5 FOXRED1 LRRC41 INO80B TIMM44 FBXL18 IDH3B TRIP4 MRPS15 UBAP2 ZNF646 ZNF384 RMRP TRMT1 PHF14 ACOT8 EPS8 ARID1A PSMD3 ANKRD13A TP73-AS1 SLX4IP MDN1 CHD8 AK2 KPNA6 NOL6 PSKH1 PEX14 RPTOR GRWD1 CES2 SZRD1 C19orf48 MICU1 GPR137 ANKRD54 RPL24 DUS3L DDX41 MRPL49 LONP1 XPO6 PPP1R12C NUDC RSAD1 RPS3 LRIG1 NDUFAB1 CACTIN RABEP2 ZNHIT1 PSMD11 MAD2L1BP AFG3L1P NELFA SIPA1L3 ALG1 MRPL28 RALGAPA1 ATP13A4 SCAF1 HDAC1 PTGES2 SDHB SLC35B1 C7orf50 SART1 TRIM56 RPL36 PSMC3 HPS4 TUBGCP6 MRPL48 RANBP1 COPS7B DHPS DAP3 FARSA ARHGAP1 TERF2 TXNDC17 LSM5 TNPO2 ARID4A PRCC IL23A PI4KB HMGXB4 TARDBP BNIP1 PPP1R8 RTF1 IWS1 CPSF7 ZNF787 XPNPEP3 INO80 RPL18 ERI1 STAMBP AKAP8L SETD1B GPBP1L1 SCAF4 PNPT1 ZNF839 SF1 SNRPB RFXANK SNAPC5 RPL29 KIAA0753 SH2B1 TRIM62 GPS1 ZSWIM3 POLR2L NDUFS6 CCAR2 RANGAP1 GRIPAP1 SHARPIN PLOD3 HDGF RBM12B CENPBD1 ATG9A CA1 RPL22 TIPIN DDX23 TOX4 LAS1L NOLC1 RPS12 SUCLG1 RPS28 GOLGA3 UQCRC2 TRIP10 STX18 BRPF1 RPL3 OGFOD3 NUP93 PARP2 NUBPL RPLP2 NMT1 RPS15 NUP205 ATP6V0D1 ZNF324B TLN2 NR1H2 CHMP4B CDC42BPA ANKMY1 RRP1B PAK1 SF3A3 GTF2F1 ZDHHC12 FAU CXXC1 RCE1 CHCHD2 SNRPD3 EIF1AD SH3BP5L TCERG1 TRMT44 DOHH RFX1 CLASRP EXOSC5 DHRS1 GAS8 HSPA9 PAFAH2 HOMER2 STRIP1 SFSWAP LMNB2 BCL6 SNORD46 PSMB5 YY1AP1 RBBP5 PDAP1 ALG10B TTBK1 IMP4 GUCD1 MED26 BOD1 FAM50B MAP3K11 TOMM22 MRPS35 PISD CLPX ERI2 LMBR1 SMG7 SUPT16H RNF220 MCRS1 LEMD2 SLC39A3 MAN2C1 TIMM9 ZSWIM4 PSMA3 DPH1 RNASEH1 GPR108 TRMT5 MRPL4 MAZ TRMT2A TMEM126B IMP3 MRPS33 PLEKHA8 HAX1 ZNF219 MPDU1 ZNF689 CDK5RAP1 ATXN7L2 ECSIT AAR2 STRADB CAST DPP9 SEC23B LRPPRC ALG12 MED18 TRMT6 ZNF668 GCDH GGA1 DDA1 SMARCD2 FLAD1 WDR83 MIR320A ESF1 SUPT5H TPR ANKZF1 TMEM183A HEATR1 MZT2B VGF AMDHD2 FDPS RPL27A HIBADH NCOA5 SMPD4 BAX TSN RECQL5 MRFAP1L1 NDUFS4 PSMC4 MRFAP1 HEXIM1 MED9 PPP1R13L CCDC107 RTCB GBA CCT7 CCT5 RPIA PAN2 CRELD2 TIMM22 SLC25A17 ZNHIT6 PMS2P3 PGBD4 EFCAB14 TFAP2A MRPL51 COG2 ZBTB40 RPL27 BECN1 PHF23 RPS8 RPL37 POLR2J3 ZNF414 RHBDD3 NUBP1 SLC3A2 KIAA0586 BAG5 MRPS23 RBM28 RFNG UQCRH RPS7 STAG3L5P-PVRIG2P-PILRB ICAM5 PSME3 CS SNRPA PHB NIPA2 TMEM87A SAR1B NUP133 GANC HMBS EFTUD2 S100PBP MRPL21 FARS2 SSBP1 RPS16 EEFSEC TOM1L2 KDM1A GART SAP30BP AKT2 CSNK2A1 RPS15A MSANTD4 SNAPC2 CLUAP1 MANBAL MAPKAPK5 UTP3 NMNAT1 ZSWIM8 SCNM1 DTD1 METTL2B NFKBIB COQ4 RPS27A PITHD1 TIPRL RPL30 TACO1 MED15 DZANK1 C17orf100 MAPKAPK3 SLC4A1AP ERCC1 SURF2 FIZ1 SNX1 SYNJ1 LETMD1 KAT5 POLR3D FAM133B DUS2 DHX30 RAD52 TIMM10 PSMD13 TUT1 BANF1 WDR89 RAB27A DCAKD SART3 ELAC2 POLR2J4 SDHAF2 MAF1 BUD31 NUP85 DNM2 DSN1 IFIH1 GTPBP10 CCDC12 ACTR10 BUD13 DPCD RPL41 SNRPC WDR87 NDUFS7 BBS9 DHODH POLR3A ZNF131 YARS2 NDUFC1 MRPS27 UBXN1 TSFM GBF1 GEMIN5 STAG3L5P SPAG7 CCDC97 ZNF507 TCHP COA6 BAZ2A TMEM38A NDUFC2 ZBTB43 RHOF MPV17 MAP4K2 CHCHD5 RPS13 WDR70 MCM8 ZFAND1 EEF1B2 TBCB R3HCC1 SP2 CEP350 FAM135A HNRNPF TERF2IP MRPL36 MTCH1 C19orf47 RLF UBC TTLL5 SRRD ZFPL1 TMEM160 FAM177A1 HARBI1 SLC25A11 ATXN1L ZFP36L1 MT-TF DESI2 AARSD1 TMUB2 SIRT3 TRIP11 TMEM41A SPAG4 KLHL7 FOXJ3 CD3EAP TRUB2 NUP107 CAMTA1 CSTF1 LANCL2 TECPR2 MRPS28 ALAD DNAJC14 PIP4K2B LINC00680 ZC2HC1C SHKBP1 NLGN2 METTL9 CCAR1 ANKRA2 NAGPA ATR HSD11B1L VEZF1 NDUFS2 PUS3 CBFB RBM42 TSR2 GAR1 MED24 NPW SPAG9 ACOX3 CUEDC2 ITFG2 IPPK RNF167 CMTR2 TSPAN31 POLR2I COMMD1 up
## SCGGAAGY_ELK1_02 0.0010101 0.0069322 0.4696697 2.416054 0 1148 SSU72 CDK13 NOC2L SRSF4 E2F4 UBR4 EDC4 B3GALT6 TBX6 TRAF7 OTUB1 RNF121 GSPT1 AAGAB RPAP1 RNPS1 SLC12A2 GTF3C1 WRAP73 KCTD13 LYPLA2 POLR1C VPS53 PRPF6 GSE1 RBCK1 CD2BP2 GPN2 TMEM222 ZNF408 BAD C1orf122 MARK2 PPP1R35 YTHDF2 PPME1 STK40 CCDC130 GNL2 SF3B3 IPO4 EIF2AK1 ZNHIT2 NTHL1 NUDT22 CXorf56 NUTF2 COG4 SPRED2 TMUB1 TRPT1 MRPS18A TUFM MSANTD2 CWC25 CDC37 CHERP DPH2 KCTD5 DAGLA FOXRED1 LRRC41 INO80B TRADD ANKS3 PMM2 XPO5 KLHL35 ZNF646 RPS5 DPP3 PEX16 ASB6 ZDHHC5 ZNF384 CREBZF TRMT1 SHANK2 PHLDB3 WDR55 GDE1 LSR SIGIRR PCGF1 DNTTIP1 ITPA FASTKD5 ARFGAP1 ZFP64 NSUN2 GRWD1 CES2 RNF181 TSC2 MTFR1L XAB2 COG7 GTF2A2 MRPL49 WDR73 NUDC TTPAL MAP3K6 RPS3 DNMT1 MAD2L1BP DHX37 RPS19BP1 PIGT TMEM62 CHPF SCAMP2 MAPK8IP3 TUBGCP4 SART1 PPP4C TFAP2C PIGO TSTA3 CCDC47 C9orf40 ATG16L1 PRDX5 FAM120AOS ZNF70 COPS7B DDOST SAMD10 ARFIP2 AP4M1 ARHGAP1 RMND5B PSMA5 LSM5 FDXR FBXL8 ARID4A KXD1 TMEM186 EP300 CPSF7 CLCN2 INO80 PICK1 ERI1 YKT6 TNPO3 SLC25A5 EPN1 TRIM11 KLHL17 ODF2 TRIM41 VAC14 SNRPB CBX8 ADAMTSL5 FIBP RFXANK MKRN1 DDX55 BLZF1 EBNA1BP2 TMEM208 GRIPAP1 GMPR2 SUPT6H USB1 TM9SF1 LRP10 CIAO1 ZKSCAN5 PDZD11 NAA60 LAS1L ACIN1 PALB2 RABGGTA GOLGA3 GGT7 ATP13A1 SPICE1 ZSCAN25 SZT2 TRMT112 MED8 FBXO22 DDX49 RPLP2 AATF DDIT3 NMT1 PRPF19 NR1H2 RAB11B EHD4 RPL11 AGPAT2 PGAM5 AGL TAX1BP1 STX10 FAM219A HERPUD2 SF3A3 TBCE TFB2M CXXC1 TAF5L EIF1AD KANSL3 SHC1 SLC38A10 U2AF2 NUDT12 TAF10 RPL32 CELF1 THAP11 CLASRP MTF1 KATNB1 EXOSC5 PSMA6 RPS14 RAD23A SFSWAP PRPF18 SNIP1 STX4 PTPN23 RBBP5 PUS1 PDAP1 CEP164 LSM4 THAP10 ZNF48 YRDC ZSCAN29 PDCD6 TOMM40 MAP3K11 TOMM22 ERI2 YIPF3 GPATCH2 HIRIP3 SLC35C2 SUPT16H WNT1 MCRS1 EDEM3 FBXW9 USE1 CCP110 PCED1A ZNF687 VPS18 UBE4A SIRT6 CSNK1E BCAT2 ZNF394 STOML2 GON4L SEC24C RRS1 GTF3C2 MPDU1 PPIL2 B3GAT3 PPAN HSP90AB1 HARS2 VPS16 DIAPH1 SYT5 TRMT6 ZNF668 GGA1 RPL37A PHKB RAVER1 TMEM191A PEX11A ZSCAN20 RPL31 TXNDC12 BCL2L1 KRIT1 C19orf57 PHF5A CRB3 ZER1 SUPT5H FAM120A CPT2 DCTN5 PER2 TNRC6A CCDC85B TP53 SH3GLB2 ATXN10 SNX12 RPL19 BABAM1 CHID1 TMEM127 USF1 SLC9A8 PSMC4 ROMO1 ZFYVE27 DAB2IP MFSD5 POLR2F NME7 TPGS1 SF3A1 CCT7 ARMC7 RAD51D GALNT10 MRPL52 NOSIP EIF3L BZW2 SLC25A17 WDR34 MRPL33 TBCC SLC25A14 CSAD MLLT6 RPL36AL MOSPD3 RPL27 CTPS2 MYL6B CNST BECN1 ZBTB8OS PHF23 RPL37 TOMM20 ZNF79 DGUOK PRKAB1 DDX42 TYMP STIM1 MON1B BIN3 TIGD4 UQCRH SON WFDC2 C12orf66 C12orf10 PSME3 DNAAF2 RNF41 DLST TCOF1 KTI12 PABPC4 UBA1 EFTUD2 C1orf210 JOSD2 CAAP1 SSBP1 RAB24 EEFSEC GART NASP SND1 SNRPE SCFD2 PSMC1 STARD3 SAP130 UTP3 NMNAT1 ZSWIM8 MLEC DLX4 TBC1D22A TNK2 MCM7 POLR2H NFKBIB EVX1 CCZ1B PSMD12 EIF2B2 TIPRL LMAN2 MED15 ITFG1 ROM1 F11R CLMN MPZL3 ERCC1 SNX1 SYNJ1 RPS6KA3 TMX1 NPRL2 C1QBP RBM19 KAT5 POLR3D HIRA RRP15 MOCS3 DHX30 EAPP MRPL27 VEGFB RSPRY1 SRP54 ALDOA TIMM10 PSMD13 ANKS1A BANF1 DCAKD UBE2V2 VRK3 CHMP2A GNL3L POGZ SDHAF2 CLDN7 SRD5A1 BUD31 UBR1 CLASP1 POLH EVC2 RALGAPB NOL12 TPM3 CNTROB SLC25A4 DPCD MYO19 RBBP4 ATP2A2 TMCO1 HDAC10 RNF168 ERCC3 UBXN1 TMEM101 UFC1 STX6 SMUG1 TIGD6 PITPNA PEX6 ZNF513 STXBP2 DHX8 DNAJC1 EFNA5 SEC61A1 LEPR ZBTB43 FANCF MLYCD MAP4K2 AKT1S1 LRRC29 MCM8 IQCK EEF1B2 C19orf47 SIPA1 HNRNPLL EML3 NFS1 SRSF9 COX8A APTX DHX15 GJB1 SUGP1 SIRT3 RPS3A SLC39A9 NUP107 FNDC8 WFDC3 NAA20 CSTF1 KDM3B PSMC2 ALAD DNAJC14 COX5B MTA2 SHKBP1 TBC1D17 TFCP2 ATR C15orf39 NDUFAF3 INO80E EIF3H GAR1 MGAT2 LASP1 EML2 COX6B1 COPE APEH KRTCAP2 RABGEF1 NMNAT2 IPPK CMTR2 TSPAN31 POLA1 KIF4A C14orf119 MTX2 RPS6 EIF5A IQCH CUL7 FBXO33 SLC25A38 CETN3 GCC2 CLEC18C SRSF6 EIF3M TTC25 NUDT5 up
## PIAS4_TARGET_GENES 0.0014104 0.0069322 0.6335822 2.415910 0 57 ISG15 C16orf91 FBXO34 TP53BP1 ISG20L2 STAP2 HES4 CAPN1 PPFIA3 CSNK1G2 TMEM259 RRNAD1 AHDC1 NSUN4 RALGAPA1 PML BRAF VPS37B CA1 RFX1 DNAJB2 RPL38 EMC10 PDE4A C12orf66 FAM71E1 CDC14B STOML1 JOSD2 CSNK2A1 ZBTB21 CCDC106 MSRB2 up
## DLX6_TARGET_GENES 0.0010549 0.0069322 0.4878704 2.410284 0 486 DNAJA3 THRAP3 TBX6 EIF3B ZNF398 GSPT1 KIAA0319L ADCY9 SRRM2 NCDN RHBDF1 FEM1A TRIB3 FBXL19 TMCO4 STK40 SF3B3 EIF6 MPG SH2D3A COG4 EDC3 TMEM54 ABCB9 SETD1A COASY ALG8 ATXN2L STK35 LRRC41 EARS2 FARSB RAD50 GOLPH3 HOXA11 MRPS15 USP54 GTPBP2 ZDHHC5 SRRT BST2 ENO1 NSUN2 KPTN NAPEPLD SNX8 ZNF786 TM9SF4 HOXB9 EFNA1 PPP1R14B FAF2 BRD9 ZNHIT1 HOXC-AS2 SCAF1 MVB12A HDAC1 CISD3 TRMT12 HKDC1 UBFD1 TTI1 PSMA5 ARID4A PRCC IL23A RTF1 FEN1 AP5Z1 KRT8 TNPO3 ZNF692 PHLDA2 SEPHS2 ESRP2 PLOD3 HDGF GPRC5A GMPR2 TM9SF1 AP2B1 PRLR RBM47 RPL22 DAGLB RPS12 OSBP ZMYND8 NOP56 GOLGA3 UQCRC2 FAM13A PDP2 PAAF1 LBX2 PDIK1L MEGF11 STX10 CLDN12 SHC1 RPL32 RPS14 HOXA11-AS SNHG11 SFSWAP SNORD46 PSMB5 STX4 SNHG8 ZNF133 RBBP5 PDAP1 SNORA84 GTF2I ZNF48 WDR25 YIPF3 CCDC124 HIRIP3 HNF4A TFF2 CTDP1 MRPS33 SEC24C HAX1 MPDU1 LRPPRC TIMM13 ACY3 ACAD9 RPL27A XPOT RPL19 TMEM258 SPATA5L1 USF1 PPP1R13L SLC16A5 PAN2 ARHGEF2 HM13-AS1 EHF TFAP2A AKAP9 NDUFA4 UBE3A CDK4 BECN1 ZBTB8OS RPS8 SLC3A2 MRPS11 MRPL54 IDH3A UQCRH SON BANP ZNF574 PSME3 CS SNRPA LINC00910 FTSJ3 MCCC2 BCL3 RNH1 TAF1D GART CSNK2A1 HINT1 MAPKAPK5 LTBR LDLR RPS27A TTC7A PSAT1 RPL30 NEMF OPLAH UQCRQ RPS23 MRPL27 SRP54 SAE1 RAB27A CLDN7 SRD5A1 BUD31 DSN1 CLASP1 NOD1 WSB2 RPL41 ARPC5L RBBP4 ZNF131 KCTD21-AS1 YARS2 PRDM10 FAM219B RHOC RNU4-86P IBTK PSMC5 OXA1L MALAT1 CCPG1 FPGS KAZALD1 MIR4258 SPATA24 NEK9 up
## ZNF592_TARGET_GENES 0.0010050 0.0069322 0.4637291 2.405189 0 1572 RERE SRSF4 VPS13D DNAJC11 MRPL20 FBXO42 DNAJA3 BAIAP2L1 ZNF282 TBX6 TMEM248 EIF3B ZNF12 SLC4A2 ZNF398 SNX18 MECR CTU2 DHDDS HMOX2 YTHDF1 TELO2 SLC12A2 NADK ADAP1 TTLL4 PANK4 NUMA1 HMGA1 DYNC1LI2 SRRM2 NOM1 FBXO34 PGBD2 TXLNA UTP14A STAU1 POLR3E PPFIA1 TRNAU1AP ADRM1 PACSIN3 ZNF408 FEM1A TTLL12 VWA1 SDF4 PMS2 TRIB3 FBXL19 CTTN TTC39A MRTO4 STK40 RCC2 TMEM201 FNBP4 EIF2AK1 VPS4A UCKL1 ZNF598 RPL13 DGAT2 NMRAL1 NOC4L TCFL5 STUB1 WWP2 GNAS ZC3H7A FAM207A REXO1 CWC25 SLC7A5 KIAA2013 SNORA74B MYBBP1A ZKSCAN2 CLPB MORC2 PAXIP1-AS1 PPFIA3 CDK5 INTS1 GLS TULP3 COASY C1orf159 SLC7A6OS KCTD5 PAXIP1 RFX2 L2HGDH BCL9L LRRC41 EMC1 SF3A2 AIMP2 TLE3 RAD50 FBXL18 IDH3B PMM2 NR6A1 ZNF609 RHOT2 NOP14 GNG4 MGA ZNF646 SAYSD1 ZGPAT SLC9A5 ZNF747 HMGXB3 DPP3 KMT2C ZNF384 REPIN1 ZNF496 EEF2K CHD2 SRRT NR0B2 IRF2BP2 RNF223 ANKRD13A ABCF3 MDN1 ADK FAM50A TMEM184A UFSP1 NAPEPLD PEX14 UQCC1 DDX51 CYB561 WRNIP1 RPTOR LAMTOR1 SZRD1 TMED3 WIZ LGALS8-AS1 ESYT2 ANKRD54 EVA1C PUM1 PRMT7 COL9A2 JOSD1 CCDC137 PPP1R12C DDX19B DCTPP1 ARHGEF5 RSAD1 PPP1R14B DUS1L PIEZO1 CTBP1 HLCS PDF DFFA CLTB EIF2B5 TRIP6 MLXIP TNIP2 CACTIN SNAPC4 ZNF746 PYCR2 LRP5 HRAS VPS37B THEM6 MAPK8IP3 DEAF1 PARK7 C7orf50 ZMYM4 TRMT12 TRPC4AP TSTA3 CDH1 HOXB6 TMEM189 PPM1A ZNF76 RNPC3 FARSA RRP1 NXT1 ARHGAP1 RBBP8NL C1orf198 PRCC SNHG7 MACC1 MAP2K2 TMEM186 ARF1 CC2D1A PER3 HOXB3 RNF4 FEN1 IWS1 FAM157A TUBB2A GIT1 ELOVL1 ARFRP1 RPL12 PICK1 THSD4 DLG5 ERI1 ANXA11 LUC7L EEF1DP1 RMI2 MAP7 CLCN7 GGT1 RHPN2 ARFGEF2 BCKDK INTS4 CCDC85C MIDN KLHL17 PNPT1 VAC14 TEAD3 ZNF32 PRSS8 TMEM63B DDX55 ATIC EBNA1BP2 TOMM34 SEPHS2 HDGF SNX25 SLC7A5P1 GALNS STK25 IFI27 RANBP10 UBTF EZR DDX23 ADAR REV1 DGCR8 ZMYND8 KLHL20 RABGGTA MIER2 DHX29 FOXK1 RHCE SBNO2 RNF213 SRSF1 ASAP3 FHL2 NMT1 PLEKHJ1 GATAD2A CHMP4B USP10 ANKLE2 RRP1B MAPK3 ZNF276 LGALS8 AGL TRAF4 CLDN12 MGME1 FOXK2 RCE1 LRRC61 KANSL3 KHNYN TADA2A VPS9D1 PVT1 TCERG1 EXOC7 C12orf76 CELF1 NDUFS3 NSFL1C ZNF584 SLC26A4 KCNC3 CANT1 SCAPER PPP4R1L SMARCC2 FAM53A MADD GAS8 MED16 HSPA9 HOMER2 STRIP1 RPS11 EML4 EPDR1 MYO18A MEPCE CHST10 PUS1 CHCHD10 PRKAR1B GOLGA8A POGK SGTA BOD1 ZNF48 LZTR1 LRRFIP1P1 TOMM40 MLPH KHSRP CLPX TRAP1 POLG TRIM45 LARP1 SUPT16H MCRS1 FAM76A CCDC88C LEMD2 MALSU1 HOXB-AS3 DUSP28 SMPD3 DPP7 CSNK1D ZMIZ2 NEK8 ZFYVE28 PROCA1 CDCA4 FRMD8 SLC25A10 PPP4R1 POLR1B MAZ YPEL3 DOK7 DBP ARL16 LRRC56 JKAMP CCS GPR160 LNX1 RPS20 ANKRD65 MGLL CERS4 SEC24C MYO1D MPDU1 B3GNT4 ZNRF2 B3GAT3 COMTD1 PPAN ST3GAL5 CAST DPP9 HARS2 DRAP1 VPS16 PCIF1 DIAPH1 SYT5 SYT17 ZNF341 ZNF668 SMARCD2 POMT2 RPL31 CYTH3 WDR83 ESF1 KRIT1 C19orf57 DEF8 NOXA1 ACSF3 SUPT5H TPR RHOBTB3 TANGO6 TMEM183A NCOA6 CILP2 TOLLIP RPS27 EXO5 LINC00893 PIH1D1 ASCC2 TP53 STX3 NCOA5 PARP12 TMEM258 CYC1 CHID1 ZFYVE27 NYAP1 MIR193A FOXRED2 L3HYPDH PRKCSH UPF1 HEXIM1 MVK ANKRD52 RNY4 NDUFA13 BPTF ARMC7 PDE4A MRPL52 ALDH5A1 NOSIP EIF3L ECHDC3 COPS6 CDK5RAP3 WEE1 NFE2L1 LACTB2 HM13-AS1 MRPS6 CP PFKFB3 FBXO31 PIM3 EHF ABCC3 CRAT CCDC57 FNIP2 TFAP2A TMEM144 MRPL33 C15orf61 SIRT7 ZNF444 DHRS13 TYSND1 SNX5 NT5C BFAR CTSH ZBTB8OS ING5 RPL37 COA3 TOMM20 POLD1 RHBDD3 CCDC136 MYH9 DGUOK SLC3A2 POLE4 SPINT2 RBM28 LIG1 TIMM50 CRK SMIM5 UQCRH POLR1A SSBP4 NRDE2 DGKZ DLG5-AS1 UBTD1 DNALI1 RAB4A ARF6 STOML1 RALGDS SURF4 PSD4 FTSJ3 MCCC2 SH3GL1 PABPC4 ZNF628 RFFL HMBS DUSP14 HMGB3P22 LRSAM1 AGPAT3 MEF2D SKIDA1 RNH1 RNU6-9 GTF3C4 TCF25 TOM1L2 CIC TCEA2 PTDSS2 RPS26 GOLGA5 ALCAM COCH CCDC120 MAPKAPK5 TSSK3 LTBR DENND6B PINK1 NRF1 METTL2B SMPD2 MFSD3 LSM10 ASPH DNM1P35 ICAM1 MTHFR ROM1 SPG11 BCL7C CERS6 CCND1 ATMIN SFT2D2 CFLAR TMC6 OPLAH C2CD2 UQCRQ CARM1 LETMD1 RPS6KA3 NPRL2 TONSL SNRNP70 KAT5 FAM133B ARHGDIA TMCO3 CHCHD1 MID1IP1 PRDM15 XYLB ZNF77 MRPL27 TSNARE1 PPA1 ALDOA SLCO4A1 PSMB4 RAB3IL1 LARP1B FBXW11 WDR89 RHNO1 DCAKD UBE2V2 LRRC37A3 SART3 GNL3L NETO2 CCDC88B DNM2 DDX11L10 ADCK2 ECE1 PXN CCDC106 FAM171A2 PTCD3 PPIH TRIM47 ACTR3C CDIP1 RBBP4 ATP2A2 PCCB PLLP POLR3A ZNF131 KCTD21-AS1 ARV1 CBLN3 SOX6 CDK20 CISD1 DNPH1 NME1 BMP8B C6orf62 RILP ALKBH2 XKR9 IMPDH2 IDH2 ZNF513 STXBP2 DHX8 PSMC5 OXA1L PKN1 SNX27 TARBP2 MALAT1 RHOF NSUN5 TSSC4 RPS13 FPGS AHCTF1 FBXW5 NDUFA10 LRFN4 BRF1 TBCB APMAP R3HCC1 PTCD1 CEP350 JUND UBXN11 HNRNPF ZNF815P RBM17 GLG1 ADI1 AC007389.1 HLTF CCDC6 EML3 PLK3 VDR FAM222A RIBC2 PTPMT1 TTC13 PPP1R3D INPP4A POLE2 SPAG4 PPFIA4 BICD2 ENDOD1 CPNE2 PAICS ZNF581 WSB1 TMED1 NUP98 STC2 ATP2B4 AKR1A1 VPS26B KDM3B NUP210 NEK11 ZNF385A STAT6 AFF4 HNRNPU GPR3 EIF2D ZNF775 CCAR1 DEF6 ABCC5 PEMT up
## HOXA1_TARGET_GENES 0.0010173 0.0069322 0.4687595 2.400751 0 1005 C16orf91 NOP9 CDK13 PDXDC1 ATAD3A DNAJC16 SLC52A3 THRAP3 RPPH1 EIF3B CDK11B NOB1 TBL3 MFN2 RAB11FIP3 DHDDS FADD RNPS1 TBRG4 ADAP1 KIAA0319L STARD10 MRPS34 CCDC86 PRPF6 TXLNA NCDN ADRM1 GPN2 TMEM222 SMARCA4 ZNF3 AP001372.2 TP53BP1 PMS2 UBE2I SPATA2 CTTN FAF1 STK40 CCDC130 ZNHIT2 THAP4 RPL13 MYO10 ZNF174 NUDT22 CXorf56 NBPF3 TMUB1 TRPT1 ISG20L2 ZNF830 CWC25 AP3D1 KIAA0895 METTL3 NPRL3 PHF12 RFX2 ABCF2 TIMM44 CDK11A SF3A2 AIMP2 FBXL18 IDH3B TRIP4 MTG2 NUBP2 WDR60 CENPT FAM220A CMTR1 EPS8 ITPA RRNAD1 SMG5 ENO1 ACP6 NSUN2 KPTN FAM122C SNX8 SLC27A5 XAB2 RPL24 POLD3 NSUN4 MRPL49 LONP1 TM9SF4 RALGAPA2 DCTPP1 EFNA1 FAF2 CHCHD3 RPS3 F2RL1 CACTIN VPS51 GCC1 RN7SL1 ATP13A4 SCAF1 PYCR2 NGDN C7orf50 PIGO TUBGCP6 ATG16L1 RANBP1 ADAT1 SDHA PPM1A SUPT3H DAP3 WDR18 RNF216 ARFIP2 NXT1 RPSA LSM5 FDXR TNPO2 PRCC ZSCAN32 HAUS5 BRMS1 SPINT1 AP5Z1 XPNPEP3 SGSM2 PICK1 ZNF692 GLOD4 SNAPC5 DDX55 TMEM208 CCDC127 BLOC1S4 CD55 CCAR2 RANGAP1 HDGF COX19 C1orf109 LINC00857 PANK2 PIGG B3GALNT2 RPS6KA1 NOP56 DHX29 RPS28 TMEM175 UQCRC2 CFDP1 TAF12 GPATCH4 ZMPSTE24 NDOR1 PTRHD1 FAM13A PARP2 C1orf226 NUBPL TFIP11 CDON NMT1 PLEKHJ1 TMEM203 CHMP4B MAN1B1 RUVBL2 CPNE1 SEMA4B TRAF4 CLDN12 ZDHHC12 FAU CXXC1 SRRM5 SH3YL1 TPCN1 NAT10 TSR1 SNRPD3 NDUFV1 MRPL24 SHC1 C12orf76 NDUFS3 THAP11 ZNF584 MYPOP DHRS1 RAD23A METTL1 SFSWAP PINX1 MAP3K13 SNORD46 YY1AP1 ZNF133 CD320 RBBP5 PUS1 MOK UBN2 ALG10B GUCD1 BOD1 MAP3K11 TOMM22 KHSRP LRRC59 ERI2 POLG PDSS2 GAK LARP1 HIRIP3 SUPT16H FBXW9 MALSU1 NAE1 ZNF26 IGSF9 MAN2C1 VPS18 UBE4A RMDN3 CTDP1 SIRT6 USP20 KIF3A TMEM52 TRMT2A PAIP1 IQCD MTHFSD FAM222B HAX1 CDK5RAP1 CBX1 ECSIT PPAN KCNK5 HARS2 VAMP8 SEC23B RPS29 DIAPH1 MED18 THAP7 ZNF317 RAVER1 ANKRD24 FLAD1 ESF1 PRMT3 ATG14 HDLBP MZT2B TM4SF1-AS1 SRI XRCC1 PIH1D1 SLC25A16 SMPD4 TOM1 PARP12 TSN RECQL5 RPS6KB2 NEAT1 RPL28 MET STYK1 TARS2 CPSF4 NAPB MVK CCT7 ENSA DMRT2 PPP2R5B SAMD4B DNAH2 STEAP2-AS1 ZNHIT6 PGBD4 NEURL4 TIPARP ZNF444 PDCD2L NIPA1 PSMF1 BECN1 RPS8 COA3 NUP214 ZNF79 TXLNG FIGNL1 GORASP2 MIS18A PSME3 ZNF217 FTSJ3 PHB PFAS BCL2L2 TYK2 SLC25A48 CAAP1 TCF25 TOM1L2 CIC MKS1 SAP30BP RPS15A FXR2 HOMER1 PARP9 DENND6B PTRH1 ATG4B FOPNL NFKBIB COQ4 GPATCH8 ERCC2 SAFB2 SPG11 DZANK1 GYS1 ARMC5 SLC4A1AP TOP1 LRRC57 KLHDC4 SNX1 ZNF324 UPP1 RC3H1 ZNF497 DUS2 RRP15 TMEM216 SRP68 ACLY MAP2K3 SLCO4A1 KDM4B ANKS1A WDR89 MORF4L2 RAB27A DCAKD GOLGA1 IFRD1 AIMP1 SRD5A1 UBAP1 SLC39A1 GTPBP10 CCDC12 ZNF425 WSB2 RAD23B MAGOH TRIM47 PCCB RPL23 GTF2H3 CDCA8 ARV1 ERCC3 MRPS27 CCT2 CISD1 SYAP1 DMAP1 GBF1 DUT ALKBH2 PSMC5 TMEM79 SEC61A1 NDUFC2 LRRC29 CASP9 MIR4258 TBCB PTCD1 ILF2 NEK9 KCTD2 COX7C SPSB3 MMACHC MRPL36 TMEM106B RLF TTLL5 TSEN2 PABPN1 SAFB up
## HOXB4_TARGET_GENES 0.0010204 0.0069322 0.4687025 2.396326 0 980 PDXDC1 SLC52A3 LINC00265 RPPH1 TBX6 GET4 SLC9A4 PUSL1 ZNF398 E4F1 GSPT1 ZNF629 HMOX2 ASPHD1 NADK KIAA0319L WRAP73 POLR1C ZNF777 MRPS34 GSE1 SLTM MGAT4B NCDN STAU1 PHF13 TP53BP1 DDI2 STK40 MCAT TAF6 PPP1R37 ZNF598 SH2D3A FASTK NMRAL1 EDC3 CDCA7L TSR3 STAP2 ECI1 METTL3 TULP3 SLC2A13 GTPBP3 ATXN2L ARHGEF19 AVL9 TRADD TIMM44 ANKS3 GOLPH3 XPO5 TRIP4 USP54 SERTAD4-AS1 SAYSD1 DPP3 ZDHHC5 FAM220A MNX1 MST1P2 ZBTB45 EME2 SLC35A3 SEZ6L2 CROCCP2 DHCR7 MVD PKM PEX14 ANK3 TRIT1 XAB2 LMF1 ANKRD54 HSD17B6 DDX41 MRPL49 CHMP4C NUDC TRMU PPP1R14B RPLP1 DFFA NLE1 CLTB TRIP6 MLXIP LRCH4 GCC1 ZNHIT1 FAM214A HOXC-AS2 SCAMP4 TMEM62 PYCR2 DDX31 MAPK8IP3 DEAF1 C7orf50 SART1 TRMT12 TRPC4AP TRIM56 TUBG1 RAB40C TUBGCP6 DDX27 RNPEP FAM120AOS L3MBTL2 RNF216 FARSA TTC22 LSM5 ETFA TNPO2 FBXL8 ARID4A IL23A MACC1 ACAP3 ELOVL1 B4GALT2 ATG2A KRT8 KIAA0895L ERI1 MAP7 FBXL12 YKT6 PNPT1 TTC31 EPHB3 MKRN1 PLOD3 HDGF NET1 TM9SF1 STK25 MPND RBM47 SLC25A39 TPD52L2 SQSTM1 AARS2 PANK2 B3GALNT2 OSBP GOLGA3 RTEL1 BRSK2 CDPF1 FBXO22 PARP2 ILF3 AATF RPS15 AP1M2 GATAD2A EHD4 PGAM5 SIN3A MAPK8IP2 PNKP ZDHHC12 GBA2 FAU NAT10 LRBA LINC00511 CHCHD2 NDUFV1 C12orf76 RFX1 ZNF584 C1GALT1 ILVBL MRPL37 ZNF335 EPDR1 EIF4G1 SREBF2 STX4 EHMT1 SNHG8 CD320 LCLAT1 FIS1 POLDIP3 IMMT PLS1 NFAT5 ERI2 ADAT3 POLG YIPF3 R3HDM4 SMG7 RBM33 LEMD2 DUSP28 HECTD1 EFNA4 IGSF9 HNF4A SLC12A9 RNF19A ZNF687 CEP70 SNORA65 RETSAT TRIM52 CCDC24 PPP4R1 NCOA7 TMEM65 POLR1B STPG1 TMEM52 DBP TMEM126B STOML2 RPS20 TJP2 CIAPIN1 SNRNP40 PPIL2 SLC50A1 DPP9 HSP90AB1 PPP2R5A NUP88 PKP4 PYGO2 RAVER1 SMARCD2 POMT2 MIR320A LMLN WDR4 NOXA1 PCNT KCTD14 FDPS PLEKHA6 MRS2 CHID1 USF1 CCDC107 NRL ACKR2 RPL9 PPP2R5B LTK ASNS PAN2 SAMD4B STEAP2-AS1 MARVELD2 COQ9 ZWINT CRAT WDR34 MAML1 OARD1 CSAD RPL27 UNKL RPS8 NUP214 RIN1 CCDC142 ZNF608 HECTD4 TESK1 FIGNL1 MZT2A SIL1 MRPS11 ELMOD3 ZMAT5 MPV17L2 BAG5 LIG1 NOL3 PPCS NPM3 HDAC4 POLR1A STAG3L5P-PVRIG2P-PILRB BANP AMER1 CS ZNF346 C2CD2L HAUS8 VKORC1 RAB35 FTSJ3 BCL3 AJUBA STAT2 GANC HMBS COPG1 HMGB3P22 AGPAT3 MEF2D GOSR1 RNH1 GTF3C4 EEFSEC KDM1A CIC WAC-AS1 USP2 NASP TIMELESS FBXO24 GOLGA5 SNRPE STARD3 PTPN12 TBC1D22A RNF44 POLR2H COQ4 RPS4X RPS27A MTHFD1L GPATCH8 SNX13 UIMC1 ZMYND12 MIR191 PTPN13 SURF2 KANK1 UQCRQ SYNJ1 IVD ZNF497 RTEL1-TNFRSF6B SNRNP70 POLR3D FAM133B RRP15 MUC1 ARMC10 XYLB PPA1 FAM221A TUT1 FBXW11 SAE1 MYO9B SHISA5 CCDC148 VRK3 SART3 NUP85 BARHL1 POLH TMEM39B IFIH1 SLC39A1 NOD1 ACTR3C SMOX PDCL3 BHLHE40 PCCB IGF2BP3 ZNF131 GTF2H3 CDCA8 YARS2 MRPS27 CCT2 DMAP1 STAG3L5P SPAG7 DUT ALKBH2 ACTR5 TMEM223 TEX264 TST PSMC5 SNX27 RHOF AKT1S1 HOTTIP CRKL RAB27B TSSC4 TTC26 ATP8B3 AHCTF1 APMAP SP2 NEK9 RNASEH2C RPS6KL1 ETNK1 MMACHC ZCCHC17 MRPL36 YAP1 C19orf47 ADI1 TYMS PABPN1 FBL DHTKD1 PLK3 SIVA1 TRIP11 MYL5 NDUFA2 ZNF860 ASAH2B TRUB2 C21orf58 SLC39A9 NISCH PIP4K2B MTA2 AFF4 USP19 ZC2HC1C TBC1D17 DVL2 ABCC5 TFCP2 COX7A2L REEP4 C3orf52 PDE4C NDUFAF3 RCN1 up
## AEBP2_TARGET_GENES 0.0010142 0.0069322 0.4671479 2.396249 0 1030 KIF16B PDXDC1 DNAJA3 GIPC1 RPPH1 EIF3B TRAF7 ZNF12 PGP NPHP4 AMBRA1 GSPT1 ZNF629 MTOR KIAA0319L RBCK1 NCDN TRNAU1AP CYB5B INPP5B SHROOM3 SCUBE2 LSG1 TMEM53 SLC7A6 DGAT2 SPRED2 CDCA7L STAP2 EVI5L ABCB9 PPFIA3 DPH2 TPBG GGCT TBC1D10B TULP3 CHEK2 KIF1B NFATC2IP NOP2 STK35 LRRC41 AVL9 TIMM44 MGRN1 NR6A1 RPLP0 ERI3 NUBP2 ZDHHC5 PHF14 LSR FBRS SRC ACOT8 EPS8 ARID1A FRMD5 ANKRD13A MVD PRMT1 ACP6 KPNA6 NOL6 SNX8 RNF181 LINC00461 MVP NIPAL3 RRBP1 MEAF6 TM9SF4 EFNA1 TMEM161A CDK16 RPLP1 DNMT1 OGDH VPS41 TMEM62 SCAF1 PRR14 HDAC1 NGDN DHX38 TRAFD1 PARK7 PHRF1 AAMP TMEM219 MNT BRAT1 MRPL48 HOXB6 FAM120AOS CEP250 COPS7B DDOST DAP3 ALKBH7 AP4M1 RMND5B CBY1 SPG7 ANKRD11 ARID4A IL23A TARDBP BNIP1 RPL18A AP5Z1 NRSN2 PRKCE FDFT1 PICK1 RPL18 KRT8 FAM227A RMI2 AKAP8L MAEA GPBP1L1 NDUFB2 AGFG2 HGS CA11 IPO13 ADAMTSL5 ZSWIM3 GRIPAP1 SHARPIN GPRC5A PDXP ATG9A PRR15 MPND RBM47 ZKSCAN5 RPL22 MED19 SQSTM1 TOX4 FAM110A GNB2 RPS12 DGCR8 OSBP ZMYND8 KLHL20 RHCE RBM15 UQCRC2 ZDHHC7 TRIP10 AKIRIN1 SRSF1 FAM13A PARP2 C9orf16 ILF3 DDX49 CDON AATF NMT1 DCAF15 RUVBL1 GATAD2A DROSHA RAB11B PCAT7 RPRD1B SLC35E2B MEGF11 ALDH4A1 SEMA4B STX10 SRRM5 DOK4 OS9 TPCN1 LRRC61 SHC1 TRMT44 TSTD1 DOHH RFX1 KATNB1 MTMR12 RPS14 MADD MAP3K13 BCL6 YY1AP1 MEPCE RBBP5 PUS1 FIS1 VPS37C EEF1D CEP164 KDM4A LSM4 PLS1 KHSRP ERI2 TJP3 POLG CCDC124 GPATCH2 LMBR1 MALSU1 DPF2 ASH1L PRKDC ZSWIM4 ZNF687 CDIPT PSMA3 ZNF774 FUS GPR108 RMDN3 RALY POLR1B STPG1 ABCA7 ARL16 SIGMAR1 GPR160 IQCD SUMF2 HOXC6 OXR1 CCDC61 HNRNPUL1 XRCC3 P4HB ZNF219 ZNF689 SLBP RIC8A DPP9 HSP90AB1 LRPPRC DIAPH1 PPP2R5A PYGO2 TIMM8B DDA1 UTP18 STT3A ZSCAN20 FLAD1 ZNF785 BCL2L1 BET1L ANKZF1 RHOBTB3 RGMB PCNT LINC00881 SRI RPS27 PER2 MAGI3 FDPS PDXDC2P RPL19 BABAM1 PTOV1 HHAT TARS2 C17orf75 IFIT3 CADPS2 PPP1R13L SLC16A5 GBA CCT7 CCT5 NRL TMX2 ASNS PAN2 UQCR10 WDR62 BZW2 NFE2L1 ZWINT ISL2 TIGD5 AKAP9 DOLPP1 DHCR24 MOSPD3 NCOA2 RPL37 ZNF414 RHBDD3 SREK1 CASC4 MRPS11 ZNF354B MPV17L2 WHAMM IDH3A UQCRH POLR1A ZNF823 CEACAM1 ZNF574 PYGB HAUS8 LIPE RUFY1 CYTH2 YIF1A UBA1 DCAF11 MCM3 EXOC4 SSBP1 TOM1L2 CIC CSNK2A1 PPIA MSANTD4 GTF3C5 PLEKHG5 CHD6 MLEC PTRH1 NHP2 UBE2S MSH3 TBC1D22A MCM7 NFKBIB RGMB-AS1 PAFAH1B3 SUCO TTC7A LMAN2 RPL30 UIMC1 PWWP2A LINC00649 SERINC5 UBA52 STARD3NL FIZ1 SNX1 RCCD1 MOCS3 RAB11B-AS1 ZNF77 HOMEZ SARS2 ANXA4 STK11IP KDM4B MYO9B POLR2A DCAKD VRK3 SART3 MFSD6 CLDN7 OTUB2 MAF1 ZFYVE21 LIMA1 DNM2 ECE1 IFIH1 JUP SYVN1 VPS72 PTCD3 TRIM68 ACTR3C TMCO1 ZNF691 BATF2 IGF2BP3 POLR3A STRIP2 PSMC3IP MRPS27 CHCHD6 FAM219B GBF1 C6orf62 SPAG7 MPZL1 GNG12-AS1 DUT CKAP5 RPN2 IBTK TUBB4B DCAF6 OXA1L TK1 MALAT1 TMEM38A PAXIP1-AS2 DDR1 AKT1S1 RPL23A GMDS POLR1D FAM161A TBCB SP2 FKBP9 SPSB3 ZNF815P MRPL36 TTLL5 VDAC1 TYMS TMEM160 PABPN1 ANP32A TMEM260 DPAGT1 UBALD2 ABHD2 VDR TTC13 DCTN4 ARG2 NPDC1 CD3EAP PDCD11 ZC3HC1 C21orf58 CDC42EP4 AMACR AP2A1 CAMTA1 LANCL2 METTL17 RFWD3 ATP6V1E2 NEDD4L PIP4K2B PRDX2 HNRNPU ZC2HC1C FAM126A SHKBP1 TBC1D17 PRELID2 NAIF1 ANKRA2 up
## CASP8AP2_TARGET_GENES 0.0011351 0.0069322 0.5044770 2.392236 0 276 DNAJA3 ZNF12 MT-TN MFN2 AAGAB WDR24 SNHG3 ZBTB17 BMS1 RCC1 MT-TC USP42 RFX2 MKRN3 TRIP4 MRPS15 SAYSD1 RNF31 PSMD3 ANKRD13A SMG5 ZNFX1 VPS51 ZMYM4 HPS4 SBF1 RANBP1 COPS7B IPP CBY1 LSM5 HMGXB4 AP5Z1 TIGD1 HUS1 FAM227A CLCN7 SCAF4 DDX55 CCAR2 SHARPIN CLIP1 COX19 TIPIN DAGLB LAS1L NOLC1 NCL RABGGTA RPL3 RBAK ARID4B TLN2 NR1H2 ZNF276 ECE2 SF3A3 JMJD4 CHCHD2 KANSL3 VPS9D1 PSME2 NDUFS3 NSFL1C C1GALT1 ALG10B POLG MAN2C1 MTND5P11 FUS TRMT2A FAM222B ZFAS1 EDF1 DPM3 EXOC8 NOXA1 THNSL1 SNX12 SNAP47 VPS25 TARS2 C17orf75 TPGS1 BZW2 FBXO31 CCDC57 FBXO28 PDCD2L PSMF1 ALG3 RPL37 MYH9 ASPHD2 NT5C3A MRPS23 RPS7 SPRTN CAAP1 SSBP1 GTF3C5 ZNF579 PTRH1 UIMC1 TOP3B SLC4A1AP NPRL2 HIRA TUT1 MAF1 LIMA1 CCDC12 GGPS1 NME1 TMEM101 DMAP1 RPN2 COA6 TMEM79 NDUFC2 FBXW5 ILF2 up
## DBP_TARGET_GENES 0.0010081 0.0069322 0.4624953 2.385682 0 1251 RNF207 AURKAIP1 MRPL20 RER1 LINC00265 C1orf174 TMEM248 EIF3B ZNF12 SLC4A2 ZNF398 GSPT1 HMOX2 RNPS1 NUMA1 STARD10 RNU4-1 MAPKBP1 SLTM TOLLIP-AS1 CD2BP2 TRNAU1AP INTS5 MAD1L1 ZNF408 ZNF3 FEM1A CCNL2 STK40 NIP7 SLC7A6 THAP4 PPP1R37 NMRAL1 GUSB EXOSC10 EXPH5 KIAA0895 ZNF764 SRCAP CLPB SETD1A PPFIA3 CDK5 METTL3 GGCT INTS1 TULP3 C1orf159 CHEK2 NOP2 PHF12 ZNF672 RFX2 ABCF2 INO80B SF3A2 TLE3 MGRN1 RAD50 FBXL18 PMM2 NR6A1 TRIP4 SNRNP200 TNRC18 TMEM259 NUBP2 ZDHHC5 PLAGL2 WDR60 FAM220A CHD2 WDR55 SRRT PCGF1 CYB5A CTU1 PSMD3 ANKRD13A THOC6 SLX4IP ADK SMG5 MVD ACP6 NSUN2 TMEM184A SNX8 CEP85 SZRD1 RPP25 GPR137 ESYT2 RPL24 ZNFX1 LONP1 EEPD1 PPP1R12C CHCHD3 DFFA EIF2B5 BRD9 CACTIN LRCH4 GCC1 OGDH EGR4 AFG3L1P NELFA VPS41 SCAF1 LCMT1 CHPF MVB12A VPS37B DDX31 DHX38 SLC35B1 AHCY SART1 AAMP RPL36 ATG16L1 TM4SF5 HOXB6 TMEM189 STIP1 TTI1 COPS7B L3MBTL2 DHPS ALKBH7 FARSA ARHGAP1 SPG7 ANKRD11 LSM5 PRCC TMEM186 AP1S1 HOXB3 PRKCE RSBN1L FDFT1 UBE2M INO80 RPL12 PICK1 RPL18 MORN1 KRT8 AKAP8L TNPO3 INTS4 NDUFB2 PRR14L ERAL1 SF1 DDX55 SH2B1 ATIC CCAR2 ARHGEF28 HDGF CLTA CENPBD1 STK25 RANBP10 ZKSCAN5 RPL22 TPD52L2 MED19 PPM1G MUS81 RPL13A C1orf109 NAA60 TOX4 GRPEL1 RPS6KA1 ACBD6 CFDP1 TRIP10 EIF3D SRSF1 SLC25A51 C9orf16 ILF3 CTNNBIP1 C19orf44 PLEKHJ1 NUP205 PRPF19 DROSHA RAB11B RPRD1B MAN1B1 CCNB1IP1 ZSCAN21 SF3A3 TFB2M ELL CXXC1 NAT10 LINC00511 SNRPD3 SH3BP5L GSTK1 SLC38A10 MED25 EXOC7 CDK12 CELF1 UBE2H DOHH KATNB1 C1GALT1 ILVBL SYNJ2 MYPOP RPS14 GMPPA HSPA9 PPRC1 KIF22 STRIP1 PITPNM1 SFSWAP PSMB5 RBBP5 PRR26 FIS1 UBN2 GUCD1 MED26 RAB19 IMMT BOD1 FAM81A LZTR1 MAP3K11 TOMM22 NABP2 CLN6 CCDC124 MCRS1 ZC3H4 LEMD2 SMPD3 ZNF688 CHAC1 ZSWIM4 USP21 SLC12A9 CDIPT UBE4A PSMA3 PSPH GPR108 CTDP1 MRPL4 TRMT11 NCOA7 MAZ BCAT2 ZNF394 DBP FAM222B MRPS33 PLEKHA8 HNRNPUL1 BCL2L12 HAX1 P4HB ZNF219 MPDU1 ZNF689 TSPAN17 ZFAS1 PPIL2 ECSIT ENC1 EPHB4 FAR2 DPP9 GPD1L BCL2L14 DIAPH1 PHKB HS3ST1 BCL2L1 KRIT1 PRMT3 WDR4 SUPT5H HCFC1R1 TOLLIP RPS27 HOXC5 TSN RECQL5 RPS6KB2 NDUFS5 USF1 TARS2 PRKCSH TPGS1 SF3A1 TSPAN8 TMEM179B TMX2 PPP2R5B ASNS SAMD4B UQCR10 MMP15 C19orf53 TIMM22 PFKFB3 RPRD2 CAMTA2 UQCC2 PGBD4 SPTLC3 CAPN8 WDR34 C15orf61 MRPL51 TBCC CHRNB1 ZBTB40 ZNF444 UBE3A CDK4 TYSND1 TATDN1 RPL27 CTNND1 CNST ZBTB8OS C12orf49 RPL37 COA3 SREK1 MYH9 ERC1 CASC4 IRF3 SIL1 NLRX1 MRPS11 ZMAT5 RBM28 TIMM50 CRK TIGD4 NPM3 RPS7 HDAC4 SON BANP C12orf10 ARF6 SNRPA PYGB GOLGA4 RUFY1 MPLKIP FTSJ3 PHB NIPA2 FOXL1 KDM2A SDR39U1 STAT2 TMEM87A GANC LRSAM1 JOSD2 SLC25A48 S100PBP EIF2B4 GTF3C4 RPS16 SNHG16 PAK1IP1 C18orf25 NBPF1 GART SAP30BP PELO TIMELESS FBXO24 RPS26 HOMER1 MAPKAPK5 NMNAT1 MBD1 RNF44 ATG4B METTL2B COQ4 RPS27A PCNA LMAN2 SMAD5 SAFB2 NEMF LINC00649 DZANK1 KCTD7 FOSL1 UPP1 LETMD1 LSM7 FAM133B MUC1 TEF COA1 RAB11B-AS1 XYLB RPL14 RAD52 SARS2 ALDOA TIMM10 SAE1 POLR2A SLC30A5 OSBPL3 RHNO1 ZSCAN22 NUP188 VRK3 SART3 GOLGA1 CCT6A WDR53 PKP2 IFRD1 SRD5A1 UBAP1 LIMA1 GPX4 UBR1 ELL3 MRPS12 MAP3K14 JUP GTPBP10 ZNF425 WSB2 IRF2BP1 SNHG15 RBBP4 PDCL3 SP140L YARS2 PA2G4 NDUFC1 CHCHD6 PRDM10 NME1 TMEM101 GBF1 C6orf62 SPAG7 ALKBH2 ETV6 BAZ2A DCAF6 PSMC5 TMEM79 SEC61A1 MPV17 AKT1S1 TTC26 RPS13 AHCTF1 CLPTM1 TMEM106C EEF1B2 GEMIN6 C15orf41 SPATA24 COX7C RPL7L1P8 SPSB3 ZNF815P MMACHC UBC SAFB XRN2 FAM83E ZNF622 COX8A ATF4 USP8 PLK3 SLC25A11 MRPL34 BBC3 AARSD1 DCTN4 MYL5 BICD2 KLHL7 NDUFA2 ZNF484 ZNF343 TMEM198 TRUB2 SYMPK LRP6 CDC42EP4 OCEL1 SLC39A9 NUP107 AP2A1 CSTF1 FBXO46 DNAJC14 NEDD4L STAT6 FAM126A TBC1D17 PEMT LRTOMT HSD11B1L NDUFS2 NDUFAF3 SF3B5 SERP1 ZMAT2 EIF3H GRK6 NDUFA11 MED24 RABGEF1 FTO ITFG2 CBX3 TMEM30A IPPK RNF167 AAAS SFXN5 C14orf119 NGRN STX16 CHEK1 VMAC EIF5A RPL5 TP53TG1 TAF1A FBXL15 TRAPPC6B GALK2 up
## FOXG1_TARGET_GENES 0.0010604 0.0069322 0.4806847 2.383236 0 508 NOP9 SRSF4 ZNF12 MLST8 RNPS1 MAPKBP1 BSDC1 SNHG12 GID8 UBE2I TBC1D22B FASTK SPRED2 WWP2 ZFYVE19 SETD1A TULP3 COASY C1orf159 LRRC41 ABCF2 EARS2 MGRN1 NARS2 ZNF747 TMEM259 HAGH SLC9A1 WDR60 PHF14 CCDC87 WDR55 LSR FBRS ARID1A MACROD1 BRPF3 ENO1 KPTN KRI1 C19orf48 GRHL3 ZNF786 RPL24 DDX41 SLC16A13 MRPL49 TM9SF4 FAF2 PDF RPS3 ZNHIT1 OASL PPP6R2 RNF10 ZMYM4 PIGO RPL36 UBFD1 DAP3 LGR6 RNF216 PSMA5 PSMG4 BNIP1 RTF1 AP5Z1 FDFT1 TNPO3 NDUFB2 CA11 CBX8 FIBP SNAPC5 EPCAM CLIP1 PLOD3 RBM47 SQSTM1 USP35 B3GALNT2 HECTD3 TLCD1 RPL3 ARID4B SLC25A51 C1orf226 PDP2 EHD4 FAHD1 SEMA4B ECE2 ARMC6 FAU EYA3 DHRS1 PAFAH2 PPRC1 SFSWAP SREBF2 YY1AP1 LZTR1 MAP3K11 TOMM22 PISD TRAP1 KCTD21 HIRIP3 FAM76A USE1 GHDC ASH1L MAN2C1 CHAC1 ZNF687 EMC10 RETSAT SLC30A10 NEK8 RALY MAZ ABCA7 CCS SPATS2L PLEKHA8 TXN2 ECSIT SLC50A1 ENC1 DPP9 DIAPH1 NCLN GGA1 UTP18 TBC1D30 TXNDC12 WDR83 TIGD2 ZER1 TPR SRI SUGP2 FDPS HIBADH MRFAP1 TARS2 C17orf75 MVK AP5S1 SAMD4B CCT3 BZW2 EHF DISP2 TMEM144 MAML1 SIL1 ELMOD3 UQCRH CS FAM71E1 MPLKIP DNAJC2 SDR39U1 TMEM87A GANC EIF2B4 NASP GOLGA5 HOMER1 POLR2H LMAN2 SLC4A1AP TSPAN1 STK11IP ALDOA C12orf65 IFRD1 OTUB2 LIMA1 SPRYD4 CSRNP2 GGPS1 YARS2 NDUFC1 CCT2 TMEM223 AKT1S1 RAPGEFL1 ILF2 RNASEH2C CEP350 RPL7L1P8 MRPL36 TMEM106B UROD CCDC6 BBC3 CDC42EP4 SRA1 AMACR PSMC2 COPA EIF2D TBC1D17 DVL2 ABCC5 HSD11B1L OTUD7B INO80E GRK6 ZNF446 RABGEF1 ITFG2 CBX3 BTF3L4 TSPAN31 PCDH1 C14orf119 KPNB1 SLC35F2 MAPK6 MTHFS FBXO33 RNF145 CAMSAP2 XRCC2 HNRNPA2B1 GAPDH PRPF4 HNRNPM DUS4L SIDT1 HNRNPA1 COL17A1 TADA3 PSPC1 MMAB TMEM170A NDUFB1 DNMBP DNAJB12 DDIT4 RSPH3 BYSL up
fgsea_plot(fgsea_res$res_c4, pathways_title='C4 cancer', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------ ---------- ---------- ---------- --------- ------------- ----- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## MORF_AATF 0.0012285 0.0061414 0.6012577 2.758964 0 191 DNAJC11 TRAPPC3 MFN2 SRRM1 RNPS1 MTOR TXLNA BMS1 TP53BP1 UBE2I GNL2 EIF6 TUFM EIF3I AIMP2 IDH3B SNRNP200 SRRT PSMD3 GTF2A2 XPO6 NUDC EIF2B5 THOP1 DHX38 SDHA DAP3 WDR18 KXD1 CLNS1A MTX1 SSRP1 FIBP PRPF8 NCL PREP DDX49 AATF RUVBL1 RUVBL2 ALDH4A1 HNRNPAB TRRAP NONO CLSTN1 ARFGAP2 SMARCC2 RAD23A SFSWAP IMMT NELFB SGTA HADH NAE1 PRKDC FUS RALY LRPPRC DDX39A POLR2C ATXN10 CYC1 TFAP4 PRKCSH PKMYT1 RTCB COPS6 COQ9 MMS19 ALG3 KHDRBS1 IDH3A CS SNRPA TCOF1 PHB PABPC4 SDR39U1 SSBP1 MLEC PIN1 UBE2L3 PSMD2 CUL1 LSM7 ACLY POLR2A NUP188 SART3 DRG1 DDB1 CCT2 BRD8 OXA1L ILF2 TERF2IP PABPN1 SAFB PSMB3 MCM2 KDM3B ADSL HNRNPU DNAJC8 SERP1 ETF1 POLR2I AFG3L2 CNPPD1 EIF3M HNRNPA2B1 HUWE1 NUP62 PSMB6 SERBP1 up
## MORF_DDB1 0.0011990 0.0061414 0.5863184 2.746862 0 226 RERE PDXDC1 OTUB1 SLC4A2 MFN2 TXLNA BMS1 TP53BP1 UBE3C GNL2 DOCK3 EIF6 CSNK1G2 PTPRA ATXN2L IDH3B SNRNP200 ADAM15 CIB1 SRRT PCGF1 PSMD3 KPNA6 XPO6 EIF2B5 MRPL28 TSTA3 SDHA TTI1 DAP3 WDR18 FDXR KXD1 PCGF2 MTX1 AHCYL1 SSRP1 SNAPC5 SH2B1 TOMM34 ATG9A PRPF8 RABGGTA GOLGA3 RAC1 PARP2 AATF RUVBL2 ALDH4A1 HNRNPAB NCOR2 TRRAP NONO FOXK2 CLSTN1 DDX46 ABR ILVBL SMARCC2 SFSWAP PDAP1 NELFB SGTA PARN PRKDC CSNK1D BRD3 ACTN4 DRAP1 LRPPRC DDX39A TPR POLR2C ATXN2 STX3 TFAP4 CPSF4 PRKCSH PDIA4 PKMYT1 RTCB SMC5 WDR62 COPS6 RPRD2 PMS2P3 MMS19 OARD1 ALG3 BECN1 BPHL KHDRBS1 BAHD1 CS TCOF1 PHB YIF1A SDR39U1 CSNK2A1 B4GALT3 MLEC PIN1 ERCC2 PSMD2 CUL1 FANCG MPST POLR2A NUP188 SART3 DRG1 DDB1 DNPH1 PEX6 BRD8 ILF2 TERF2IP HLTF ELK1 EML3 COX8A SLC25A11 CHD3 TMED1 MCM2 KDM3B DNAJC8 SERP1 PLIN3 AFG3L2 CETN3 HNRNPA2B1 TUBGCP2 HUWE1 PRPF4 STK19 NFRKB NUP62 PSMB6 up
## MORF_CSNK2B 0.0011655 0.0061414 0.5771141 2.739346 0 258 RER1 EIF3B SLC4A2 TRAPPC3 TBL3 AKR7A2 DOCK3 TUFM EIF3I AP3D1 CHERP GGCT ALG8 SF3A2 SNRNP200 JTB DHCR7 PRMT1 DDX19B CTBP1 NDUFAB1 PSMB2 HDAC1 SDHB PARK7 RNPEP SDHA DDOST DAP3 KXD1 TARDBP COMMD4 MAP2K2 FEN1 TUBB2A MAEA EIF3C FIBP ATIC HDGF TRIM28 CLTA PPM1G UBAP2L PRRC2C GNB2 UQCRC2 RAC1 SRSF1 ILF3 DDX49 RUVBL2 HNRNPAB SF3B2 NONO DAP NDUFV1 NDUFS3 RAD23A HSPA9 LMNB2 EIF4G1 PDAP1 EI24 LSM4 PDCD6 LARP1 SMG7 FUS RALY CHD4 HNRNPUL1 SEC24C HAX1 SMARCD2 FAM120A NDUFS8 ATXN10 NDUFS4 CYC1 NDUFS5 PTOV1 SF3A1 CCT7 CCT5 CCT3 CDK4 DGUOK SLC3A2 KHDRBS1 IMPDH1 UQCRH GLO1 CS GNB1 SNRPA UBA1 MFAP1 SNRPD2 EIF2B4 SSBP1 COX4I1 SNRPE NHP2 MCM7 ACOT7 PCNA UBE2L3 MBTPS1 C1QBP ARHGDIA COA1 ACLY PSMB4 BANF1 DRG1 IFRD1 SLC1A5 GPX4 RAD23B RBBP4 NDUFC1 CCT2 PPP2R1A RBM14 MPV17 LSS VDAC1 FBL SRSF9 TMED9 COX5B NDUFS2 COX6B1 COPE CBX3 TECR POLR2I AFG3L2 RBMX HNRNPA2B1 HUWE1 YWHAE CLPP RHEB SEC13 KDELR1 XRCC6 GMPS TMEM147 TCEA1 URM1 up
## MORF_PHB 0.0013228 0.0061414 0.6274286 2.692890 0 113 OTUB1 MFN2 BMS1 TP53BP1 GNL2 EIF6 IGSF9B ADAM15 CIB1 SRRT PCGF1 PSMD3 XPO6 MRPL28 TSTA3 WDR18 FDXR PCGF2 MTX1 ERAL1 SH2B1 TOMM34 PRPF8 RABGGTA AATF ALDH4A1 HMG20B ILVBL SFSWAP NELFB PARN MCRS1 CSNK1D BRD3 TPR TFAP4 CPSF4 PRKCSH PKMYT1 RTCB WDR62 COPS6 RPRD2 BPHL BAHD1 IDH3A CS TCOF1 PSD4 PHB SDR39U1 B4GALT3 MLEC PSMD2 FANCG MPST POLR2A NUP188 DRG1 DDB1 LSM12 ILF2 TERF2IP SLC12A4 PABPN1 ELK1 EML3 SLC25A11 CHD3 DNAJC8 GRK6 PLIN3 AFG3L2 DRG2 CNPPD1 TUBGCP2 STK19 NFRKB NUP62 PSMB6 up
## MORF_BUB3 0.0011820 0.0061414 0.5687058 2.681820 0 243 DNAJC11 EDC4 TRAPPC3 SRRM1 AKR7A2 DOCK3 TUFM EIF3I CHERP SF3A2 SNRNP200 AK2 TFDP1 GTF2A2 DDX19B NUDC THOP1 DNMT1 PSMB2 HDAC1 SDHB PARK7 RSL1D1 RNPEP SDHA DDOST DAP3 KXD1 TARDBP MAP2K2 FEN1 TNPO3 SSRP1 FIBP RANGAP1 TRIM28 PPM1G UBAP2L PRPF8 NCL SRSF1 ILF3 DDX49 AATF SRM RUVBL2 HNRNPAB SF3B2 NONO NDUFV1 NDUFS3 RAD23A HSPA9 LMNB2 SREBF2 TXNL4A EI24 IMMT LSM4 KHSRP HADH NAE1 PRKDC CHAF1A FUS NUDT1 HNRNPUL1 SEC24C HAX1 SLBP LRPPRC ATXN10 XPOT NDUFS4 CYC1 NDUFS5 CCT7 CCT5 CCT3 ZWINT PPIE DGUOK KHDRBS1 IMPDH1 GOT2 UQCRH GLO1 CS GNB1 SNRPA PABPC4 MCM3 SSBP1 NASP SNRPE UBE2S MCM7 PCNA UBE2L3 LSM7 ACLY NUP188 DRG1 IFRD1 SLC1A5 RBBP4 NDUFC1 MRPS27 CCT2 PPP2R1A DUT IMPDH2 BRD8 ILF2 VDAC1 TYMS SAFB ANP32A FBL SRSF9 TMED9 PAICS MCM2 HNRNPU NDUFS2 DNAJC8 SERP1 CBX3 POLA2 POLR2I AFG3L2 STK24 RBMX HNRNPA2B1 up
## MORF_FBL 0.0013055 0.0061414 0.6162106 2.678553 0 129 EIF3B TBL3 RNPS1 UBE2I DOCK3 TUFM EIF3I SF3A2 IDH3B JTB PRMT1 PSMB2 AHCY PARK7 RSL1D1 DDOST RPL10A KXD1 TARDBP CLNS1A EIF3C SNRPB FIBP HDGF TRIM28 PPM1G NCL ILF3 DDX49 RUVBL2 HNRNPAB FAU NONO NDUFV1 NDUFS3 RAD23A PDAP1 LSM4 EIF3G FUS RALY NUDT1 HNRNPUL1 HSP90AB1 BTF3 ATXN10 CYC1 CCT7 CCT3 TOMM20 KHDRBS1 UQCRH CS SNRPA SNRPD2 SSBP1 SNRPE MCM7 PCNA UBE2L3 SUMO3 LSM7 C1QBP COA1 RPL14 BANF1 DRG1 RBBP4 CCT2 NME1 PPP2R1A IMPDH2 ILF2 FBL SRSF9 up
## MORF_NME2 0.0012788 0.0061414 0.6058539 2.670571 0 141 OTUB1 LYPLA2 UBE2I RPL13 GNAS TSR3 RPLP0 RPS5 JTB DNPEP ENO1 RPL24 RPS3 RPL18A RPL12 RPL18 RPL35 SNRPB HDGF RPL13A RPS12 EEF1A2 C9orf16 RPLP2 RPL11 FAU RPL32 RPS14 RPS11 PDAP1 EEF1D RPL38 RALY STOML2 RPS20 SSNA1 HSP90AB1 RPS29 RPL31 BTF3 SSR2 RPS27 RPL27A RPL19 CYC1 EEF2 CCT7 MRPL23 RPL9 COPS6 RPL36AL RPL27 RPS8 RPS7 RPL34 UBA1 RPS16 COX4I1 PPIA RPS15A HINT1 SNRPE PSMC1 RPL8 POLR2H RPS4X RPS27A RPL30 SUMO3 RPS23 ALDOA PSMB4 BANF1 DRG1 NME1 SPAG7 RPL23A RPS13 TBCB COX7C NDUFA1 UBC COX8A NDUFA2 RPS3A COX5B COX7A2L up
## MORF_RAD23A 0.0011377 0.0061414 0.5529123 2.665476 0 304 DNAJC11 EDC4 EIF3B TRAPPC3 TBL3 SRRM1 RNPS1 DDX19A AKR7A2 DOCK3 TUFM EIF3I AP3D1 CHERP SF3A2 MGRN1 IDH3B SNRNP200 JTB DHCR7 AK2 TFDP1 GTF2A2 DDX19B NUDC PIEZO1 CTBP1 THOP1 DNMT1 PSMB2 HDAC1 DHX38 SDHB DEAF1 PARK7 RSL1D1 RNPEP SDHA DDOST FARSA KXD1 TARDBP MAP2K2 TNPO3 FIBP HDGF TRIM28 CLTA CIAO1 PPM1G UBAP2L PRPF8 PRRC2C GNB2 NCL PREP SRSF1 RNF126 ILF3 DDX49 AATF NUP205 RUVBL2 HNRNPAB SF3B2 NONO NDUFV1 NDUFS3 RAD23A HSPA9 LMNB2 SREBF2 TXNL4A EI24 IMMT LSM4 KHSRP HADH LARP1 PRKDC FUS NUDT1 CHD4 HNRNPUL1 SEC24C HAX1 SLBP LRPPRC DIAPH1 SMARCD2 DDX39A KRIT1 FAM120A NDUFS8 ATXN10 XPOT NDUFS4 CYC1 NDUFS5 SF3A1 RTCB CCT7 CCT5 RPIA ZWINT PPIE TOMM20 DGUOK SLC3A2 KHDRBS1 IMPDH1 NPM3 GOT2 UQCRH GLO1 DGKZ CS GNB1 SNRPA PABPC4 MFAP1 MCM3 SSBP1 SNRPE ACOT7 UBE2L3 ACLY POLR2A NUP188 CHMP2A DRG1 IFRD1 SLC1A5 MRPS12 MAGOH RBBP4 ZNF131 NDUFC1 CCT2 PPP2R1A DUT PKN1 ILF2 VDAC1 TYMS PABPN1 SAFB ANP32A FBL SRSF9 DHX15 TMED9 MCM2 HNRNPU NDUFS2 DNAJC8 SERP1 EIF3H COPE CBX3 POLA2 POLR2I up
## MORF_SOD1 0.0011792 0.0061414 0.5617683 2.654301 0 247 EIF3B SLC4A2 TRAPPC3 TBL3 GSPT1 AKR7A2 DOCK3 PGRMC1 TUFM EIF3I CHERP GGCT ALG8 AIMP2 SNRNP200 PRMT1 NUDC NDUFAB1 PSMB2 PARK7 SDHA ETFA KXD1 TARDBP MAP2K2 CLNS1A FEN1 EIF3C FIBP ATIC TRIM28 PPM1G UBAP2L UQCRC2 CFDP1 RAC1 SRSF1 ILF3 DDX49 RUVBL2 HNRNPAB SF3B2 NONO DAP NDUFV1 NDUFS3 RAD23A HSPA9 EI24 LSM4 PDCD6 LARP1 SMG7 PSMA3 FUS STOML2 HAX1 LRPPRC UTP18 SMARCD2 FAM120A NDUFS8 FDPS ATXN10 XPOT CYC1 NDUFS5 CCT7 CCT5 ENSA CCT3 SEC61G MAML1 CDK4 DGUOK SLC3A2 KHDRBS1 UQCRH GLO1 CS SNRPA MFAP1 EIF2B4 SSBP1 COX4I1 SNRPE PSMC1 NHP2 ACOT7 PCNA UBE2L3 TPGS2 C1QBP COA1 ACLY PSMB4 FBXW11 BANF1 MORF4L2 SART3 DRG1 IFRD1 RAD23B MAGOH FAM20B NDUFC1 CCT2 NME1 C6orf62 PPP2R1A MPV17 TMEM106C ILF2 LSS RPA1 VDAC1 FBL SRSF9 up
## MORF_UBE2I 0.0012077 0.0061414 0.5679384 2.648571 0 219 UBN1 OTUB1 RNPS1 LYPLA2 UBE2I EIF6 RPL13 GNAS TUFM EIF3I PTBP1 IDH3B SNRNP200 RPS5 ZNF384 JTB RPL24 PUM1 CTBP1 NGDN DHX38 PARK7 SART1 DAP3 RPL10A KXD1 TARDBP RPL18A RPL18 HGS SNRPB HDGF TRIM28 RPL22 PRPF8 GNB2 RPS12 NCL EIF3D ILF3 DDX49 RPLP2 AATF RPL11 HNRNPAB FAU NONO NDUFS3 ARFGAP2 RPS11 PDAP1 EEF1D FUS RALY NUDT1 CHD4 HNRNPUL1 HSP90AB1 RPL31 BTF3 SSR2 ATXN10 RPL19 CYC1 EEF2 CCT7 MRPL23 RPL9 COPS6 RPL27 KHDRBS1 UQCRH RPS7 CS RPL34 UBA1 SDR39U1 COX4I1 PPIA HINT1 SNRPE RPS27A RPL30 UBE2L3 TOP1 SUMO3 LSM7 SNRNP70 RPL14 BANF1 POLR2A NUP188 DRG1 CCT2 PPP2R1A BRD8 OXA1L RPS13 TBCB ILF2 COX7C UBC ZFPL1 FBL SRSF9 COX8A ATF4 FOXJ3 RPS3A PSMB3 COX5B COX7A2L DNAJC8 EIF3H COX6B1 CBX3 POLR2I RPS6 RPL5 CNPPD1 EIF3M RBMX HNRNPA2B1 HUWE1 HNRNPM HNRNPA1 SNRPB2 RPS24 up
## MORF_RAD54L 0.0013605 0.0061414 0.6395464 2.648033 0 88 DNAJC11 SRRM1 TXLNA BMS1 PWP2 GNL2 EIF3I CDK11A TFDP1 GTF2A2 XPO6 NUDC DFFA THOP1 DNMT1 TNPO3 SSRP1 SRPK1 PRPF8 PREP RUVBL2 TRRAP DDX46 SFSWAP IMMT SGTA KHSRP HADH NAE1 PRKDC CHAF1A LRPPRC DDX39A PKMYT1 ZWINT MMS19 ALG3 GOT2 IDH3A CS TCOF1 PABPC4 SSBP1 MLEC MZF1 RAD54L POLR2A NUP188 THOC2 ZNF131 up
## MORF_PRKDC 0.0012547 0.0061414 0.5830365 2.630608 0 166 DNAJC11 SRRM1 TXLNA BMS1 AKR7A2 PWP2 GNL2 EIF3I CDK11A SNRNP200 PSMD3 AK2 TFDP1 GTF2A2 XPO6 DDX19B NUDC DFFA THOP1 DNMT1 DEAF1 RNPEP WDR18 KXD1 TNPO3 SSRP1 SRPK1 PRPF8 AATF RUVBL1 RUVBL2 TRRAP NONO DDX46 RAD23A SREBF2 TXNL4A EI24 IMMT KHSRP HADH NAE1 PRKDC CHAF1A NUDT1 SLBP LRPPRC DIAPH1 DDX39A ATXN10 TFAP4 PKMYT1 CCT5 RPIA COQ9 ZWINT MMS19 PPIE ALG3 KHDRBS1 NPM3 GOT2 IDH3A CS GNB1 SNRPA TCOF1 PABPC4 MCM3 SSBP1 MLEC PIN1 MZF1 PSMD2 RAD54L POLR2A NUP188 DDB1 ZNF131 MRPS27 DUT BRD8 ILF2 TYMS PABPN1 SAFB ANP32A up
## GCM_TPT1 0.0014225 0.0061414 0.6787051 2.613096 0 59 RPS21 RPLP0 RPS2 RPLP1 RPS3 RPL10A RPSA RPL18 RPL35 RPL29 RPL13A NCL RPS28 RPL3 RPLP2 RPL11 RPL32 RPS14 RPS11 RPL38 RPS29 RPL31 RPL27A RPL19 RPL28 EEF2 RPL9 RPL27 RPS8 RPS7 RPL34 RPS16 PPIA RPL35A RPS27A UBA52 RPS23 RPL14 RPL23 RPL4 RPL23A up
## MORF_DAP3 0.0012361 0.0061414 0.5725840 2.613049 0 179 TRAPPC3 TBL3 UBE2I EIF6 TUFM EIF3I IDH3B SNRNP200 JTB DNPEP CTBP1 EIF2B5 PSMB2 PARK7 SDHA DDOST DAP3 KXD1 CLNS1A SLC25A5 AHCYL1 SNRPB FIBP NCL DDX49 AATF RUVBL2 HNRNPAB NONO NDUFV1 NDUFS3 ARFGAP2 SMARCC2 PDAP1 NELFB BRD3 RALY STOML2 HNRNPUL1 HAX1 HSP90AB1 LRPPRC FAM120A SSR2 FDPS ATXN10 CYC1 RTCB CCT7 MRPL23 COPS6 CCT3 ALG3 DGUOK KHDRBS1 IMPDH1 UQCRH CS SNRPA UBA1 SDR39U1 EIF2B4 COX4I1 SNRPE POLR2H PIN1 UBE2L3 PSMD2 ACLY PSMB4 FBXW11 BANF1 NUP188 NIPSNAP1 DRG1 DDB1 CCT2 PPP2R1A RPN2 BRD8 OXA1L TBCB ILF2 COX7C SRSF9 COX8A PSMB3 SETD3 COX5B COX7A2L DNAJC8 SERP1 COX6B1 CBX3 POLR2I AFG3L2 EIF3M DDT HNRNPA2B1 HUWE1 up
## MORF_EIF3S2 0.0012077 0.0061414 0.5590022 2.607935 0 220 SLC4A2 TBL3 SRRM1 RNPS1 TXLNA AKR7A2 UBE2I DOCK3 TUFM EIF3I SF3A2 IDH3B SNRNP200 AK2 GTF2A2 DDX19B NUDC THOP1 DNMT1 PSMB2 SDHB DEAF1 PARK7 RSL1D1 RNPEP DDOST DAP3 WDR18 KXD1 MAP2K2 CLNS1A SLC25A5 SSRP1 FIBP CIAO1 PPM1G PRPF8 GNB2 NCL EIF3D ILF3 DDX49 AATF SRM RUVBL2 HNRNPAB NONO NDUFV1 RAD23A SREBF2 TXNL4A IMMT LSM4 HADH NAE1 PRKDC CHAF1A FUS NUDT1 LRPPRC POLR2C ATXN10 CYC1 NDUFS5 PKMYT1 RTCB CCT7 RPIA COQ9 PPIE ALG3 TOMM20 DGUOK SLC3A2 KHDRBS1 IMPDH1 NPM3 UQCRH CS GNB1 SNRPA TCOF1 PABPC4 SSBP1 SNRPE MLEC PIN1 UBE2L3 PSMD2 LSM7 RPL14 ACLY RAD54L POLR2A NUP188 DRG1 IFRD1 ZNF131 MRPS27 CCT2 PPP2R1A DUT IMPDH2 BRD8 OXA1L ILF2 VDAC1 PABPN1 SAFB FBL SRSF9 ATF4 MCM2 NDUFS2 DNAJC8 SERP1 EIF3H CBX3 POLR2I AFG3L2 EIF3M HNRNPA2B1 HUWE1 CLPP SERBP1 RHEB CAPRIN1 XRCC6 TCEA1 TIMM17A up
## MORF_RAN 0.0011862 0.0061414 0.5534935 2.604345 0 239 RNPS1 UBE2I DOCK3 RPL13 GNAS TUFM PTBP1 IDH3B SNRNP200 RPS5 JTB PRMT1 RPL24 CTBP1 NDUFAB1 PSMB2 HDAC1 PARK7 SDHA DAP3 KXD1 TARDBP COMMD4 CLNS1A TUBB2A RPL18 SLC25A5 EIF3C SNRPB FIBP HDGF TRIM28 CLTA PPM1G RPS12 NCL UQCRC2 RAC1 DDX49 RPLP2 RPL11 RUVBL2 HNRNPAB FAU NONO NDUFV1 NDUFS3 RAD23A PDAP1 EEF1D PDCD6 FUS RALY STOML2 HNRNPUL1 HAX1 HSP90AB1 UTP18 SMARCD2 BTF3 SSR2 FDPS ATXN10 CYC1 NDUFS5 EEF2 CCT7 MRPL23 COPS6 CCT3 RPL36AL MYL6B KHDRBS1 UQCRH CS SNRPA UBA1 SNRPD2 SSBP1 COX4I1 PPIA HINT1 SNRPE PSMC1 POLR2H RPS27A PCNA RPL30 UBE2L3 SUMO3 C1QBP COA1 RPL14 ACLY PSMB4 BANF1 NIPSNAP1 DRG1 MRPS12 CCT2 NME1 PPP2R1A RPN2 RPL23A RPS13 ILF2 COX7C NDUFA1 FBL SRSF9 COX8A NDUFA2 PSMB3 COX5B COX7A2L DNAJC8 EIF3H COX6B1 COPE CBX3 POLR2I RPS6 RPL5 EIF3M RBMX HNRNPA2B1 HUWE1 SNRPB2 RPS24 PSMB6 up
## MORF_TPT1 0.0013587 0.0061414 0.6226284 2.597252 0 92 LYPLA2 RPL13 RPLP0 RPS5 RPL24 RPLP1 RPS3 RPL10A RPL18A RPL12 RPL18 RPL29 RPL22 RPL13A RPS12 RPL3 RPLP2 RPL11 FAU RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL31 BTF3 RPS27 RPL27A RPL19 RPL28 EEF2 RPL9 RPL27 RPS8 RPL37 RPS7 ARAF RPL34 RPS16 PPIA RPS15A RPL8 RPS4X RPS27A RPL30 RPS23 RPL23 RPL4 RPL23A RPS13 EEF1B2 COX7C JUND UBC ZFPL1 up
## MORF_XRCC5 0.0012034 0.0061414 0.5573173 2.583842 0 209 DNAJC11 TRAPPC3 SRRM1 RNPS1 DDX19A TXLNA AKR7A2 UBE2I DOCK3 TUFM EIF3I AP3D1 PTPRA PTBP1 MGRN1 IDH3B SNRNP200 JTB GTF2A2 DDX19B NUDC CTBP1 THOP1 DNMT1 HDAC1 SDHB PARK7 RNPEP DAP3 WDR18 KXD1 TARDBP SSRP1 FIBP PPM1G PRPF8 NCL EIF3D SRSF1 DDX49 AATF RUVBL2 HNRNPAB TRRAP NONO NDUFV1 TCERG1 SMARCC2 RAD23A SREBF2 TXNL4A IMMT HADH NAE1 PRKDC CHAF1A FUS NUDT1 HNRNPUL1 HAX1 SLBP LRPPRC DIAPH1 ATXN10 NDUFS4 DHX9 NDUFS5 CCT7 RPIA COQ9 PPIE TOMM20 KHDRBS1 IMPDH1 UQCRH CS GNB1 SNRPA PABPC4 SSBP1 SNRPE MLEC RNF44 PIN1 UBE2L3 LSM7 SNRNP70 ACLY POLR2A NUP188 IFRD1 CCT2 DUT BRD8 ILF2 TYMS PABPN1 SAFB ANP32A SRSF9 MCM2 COX5B HNRNPU NDUFS2 CBFB DNAJC8 EIF3H POLA2 AFG3L2 STK24 EIF3M HNRNPA2B1 up
## MORF_GNB1 0.0011628 0.0061414 0.5430305 2.583064 0 274 EDC4 TRAPPC3 SRRM1 RNPS1 DDX19A TXLNA AKR7A2 DOCK3 GUSB TUFM EIF3I AP3D1 PTPRA ATXN2L SF3A2 PTBP1 MGRN1 IDH3B SNRNP200 JTB AK2 GTF2A2 XPO6 DDX19B NUDC CTBP1 THOP1 DNMT1 PSMB2 HDAC1 SDHB PARK7 RNPEP SDHA DDOST KXD1 TARDBP MAP2K2 RNF4 TNPO3 AHCYL1 TRIM28 PPM1G PRPF8 PRRC2C GNB2 NCL EIF3D ILF3 DDX49 RUVBL2 HNRNPAB TAX1BP1 NCOR2 NONO CLSTN1 NDUFV1 SMARCC2 RAD23A SREBF2 TXNL4A EI24 IMMT MAP3K11 KHSRP HADH GAK PRKDC FUS NUDT1 CHD4 HNRNPUL1 SEC24C HAX1 SLBP LRPPRC DIAPH1 POLR2C SUGP2 ATXN10 NDUFS4 NDUFS5 SF3A1 RTCB CCT7 RPIA TRAK1 PPIE TOMM20 DGUOK KHDRBS1 IMPDH1 GOT2 UQCRH DGKZ CS GNB1 SNRPA PABPC4 SSBP1 SND1 SNRPE MLEC UBE2S RNF44 PIN1 UBE2L3 LSM7 FBXW11 POLR2A NUP188 IFRD1 RBBP4 ZNF131 NDUFC1 PPP2R1A DUT BAZ2A BRD8 OXA1L PKN1 ILF2 VDAC1 TYMS PABPN1 SAFB ANP32A SRSF9 ATF4 TMED9 MCM2 HNRNPU NDUFS2 CBFB DNAJC8 SERP1 EIF3H COPE CBX3 POLA2 ASXL1 AFG3L2 RMND5A STK24 EIF3M RBMX HNRNPA2B1 up
## MORF_HDAC2 0.0011792 0.0061414 0.5454699 2.577293 0 247 DNAJC11 EDC4 TRAPPC3 SRRM1 DDX19A TXLNA BMS1 AKR7A2 GNL2 DOCK3 TUFM EIF3I CHERP CDK11A AIMP2 SNRNP200 TFDP1 GTF2A2 TM9SF4 XPO6 DDX19B NUDC DFFA DNMT1 PSMB2 NELFA HDAC1 SDHB ZMYM4 RANBP1 RNPEP SDHA KXD1 TARDBP MAP2K2 CLNS1A TNPO3 SSRP1 FIBP PPM1G PRPF8 UQCRC2 PREP SRSF1 RNF126 ILF3 AATF RUVBL2 HNRNPAB NONO NDUFV1 DDX46 TCERG1 RAD23A HSPA9 TXNL4A EI24 IMMT SGTA KHSRP HADH NAE1 PRKDC CHAF1A FUS SEC24C SLBP LRPPRC DDX39A KRIT1 FAM120A POLR2C ATXN10 XPOT TFAP4 RTCB CCT5 COQ9 ZWINT MMS19 DGUOK KHDRBS1 GOT2 SON DGKZ CS GNB1 SNRPA PABPC4 MFAP1 SSBP1 SNRPE MLEC RNF44 CUL1 FBXW11 RAD54L POLR2A NUP188 SART3 DRG1 IFRD1 THOC2 MAGOH ZNF131 NDUFC1 MRPS27 CCT2 C6orf62 DUT ILF2 RPA1 VDAC1 PABPN1 SAFB ANP32A MCM2 HNRNPU DNAJC8 SERP1 ETF1 POLR2I MTX2 AFG3L2 STK24 EIF3M RBMX HNRNPA2B1 up
## GNF2_EIF3S6 0.0013193 0.0061414 0.6002853 2.573132 0 110 SRRM1 RPL13 RPS21 RPL24 RPS2 RPS3 RPL36 DAP3 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 SLC7A5P1 RPL22 RPL13A RPS12 RPS28 EIF3D RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPL38 RPS20 RPS29 RPL31 BTF3 RPL27A RPL19 RPL28 RPL9 EIF3L RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 TAF1D RPS16 RPL8 RPL35A RPS4X RPL30 UBA52 LSM7 RPS23 RPL14 AIMP1 RPL41 RPL23 RPL4 RPL23A POLR1D RPS13 EEF1B2 COX7C FBL RPS3A EIF3H RPS6 PABPC3 RPL5 PMPCB HNRNPA1 RPS24 up
## MORF_NPM1 0.0012626 0.0061414 0.5773576 2.571797 0 149 RNPS1 UBE2I RPL13 GNAS RPLP0 RPS5 JTB ENO1 RPL24 RPS2 RPLP1 RPS3 PARK7 RPL10A RPL18A RPL12 RPL18 RPL35 SNRPB RPL29 HDGF RPL22 RPL13A RPS12 NCL RPS28 EIF3D RPL3 DDX49 RPLP2 RPL11 FAU NONO RPL32 RPS14 RPS11 EEF1D RPL38 MAZ RPS20 HSP90AB1 RPS29 RPL31 BTF3 RPS27 RPL27A RPL19 RPL28 EEF2 CCT7 MRPL23 RPL9 COPS6 RPL27 RPS8 RPL37 UQCRH RPS7 RPL34 RPS16 COX4I1 PPIA RPS15A HINT1 SNRPE RPL8 RPS4X RPS27A RPL30 UBE2L3 SUMO3 RPS23 RPL14 DRG1 RPL23 CCT2 RPL4 RPL23A RPS13 EEF1B2 COX7C UBC up
## MORF_PRKAG1 0.0012092 0.0061414 0.5562036 2.568370 0 203 PDXDC1 OTUB1 SLC4A2 MFN2 TXLNA BMS1 TP53BP1 UBE3C GNL2 DOCK3 EIF3I CSNK1G2 ATXN2L PMM2 SNRNP200 ADAM15 CIB1 SRRT PCGF1 PSMD3 KPNA6 XPO6 EIF2B5 MRPL28 TSTA3 SDHA DAP3 KXD1 MTX1 AHCYL1 SH2B1 TOMM34 PRPF8 GOLGA3 RAC1 PARP2 AATF RUVBL2 ALDH4A1 NCOR2 NONO CLSTN1 ABR ILVBL SFSWAP NELFB SGTA PARN CSNK1D BRD3 DRAP1 LRPPRC TPR POLR2C ATXN2 TFAP4 CPSF4 PRKCSH PKMYT1 RTCB COPS6 COQ9 RPRD2 MMS19 OARD1 ALG3 BECN1 BPHL KHDRBS1 BAHD1 CS TCOF1 PHB YIF1A SDR39U1 CSNK2A1 B4GALT3 MLEC MZF1 PSMD2 FANCG RPS6KA3 MPST FBXW11 POLR2A NUP188 NIPSNAP1 SART3 DRG1 DDB1 LSM12 PPP2R1A RPN2 BRD8 ILF2 TERF2IP GLG1 PABPN1 HLTF EML3 COX8A SLC25A11 CHD3 TMED1 KDM3B DNAJC8 SERP1 PLIN3 AFG3L2 CETN3 HNRNPA2B1 HUWE1 STK19 NFRKB NUP62 PSMB6 up
## MORF_DNMT1 0.0013316 0.0061414 0.6006255 2.546385 0 103 DNAJC11 SRRM1 EIF3I CDK11A SNRNP200 TFDP1 GTF2A2 DDX19B NUDC DNMT1 KXD1 TARDBP TNPO3 SSRP1 EBNA1BP2 SRPK1 PPM1G PRPF8 SRSF1 RUVBL2 SF3A3 TRRAP NONO TCERG1 RAD23A LMNB2 SREBF2 TXNL4A IMMT KHSRP HADH NAE1 PRKDC CHAF1A FUS NUDT1 SLBP LRPPRC CCT5 RPIA ZWINT PPIE KHDRBS1 GOT2 CS GNB1 SNRPA PABPC4 MCM3 SSBP1 NASP RAD54L NUP188 ZNF131 MRPS27 DUT TYMS SAFB ANP32A MCM2 HNRNPU CBFB POLA2 AFG3L2 HNRNPA2B1 HNRNPM CLPP up
## MORF_PSMC1 0.0012469 0.0061414 0.5594066 2.542066 0 175 RER1 EIF3B PSMC6 ADRM1 TSR3 AKT1 GGCT JTB DNPEP PRMT1 NDUFAB1 MAD2L1BP PPP4C PSMC3 ETFA COMMD4 MAEA EIF3C GLOD4 ATIC SEPHS2 CLTA SLC7A5P1 TM9SF1 ADAR EEF1A2 CFDP1 C9orf16 HNRNPAB SF3B2 NDUFS3 PSMB5 EEF1D PDCD6 SMG7 CDIPT UBE4A PSMA3 STOML2 CTCF HNRNPUL1 SSNA1 HARS2 UTP18 SMARCD2 SSR2 TMEM183A CYC1 PSMC4 CCT7 ENSA RPL36AL MRPS11 PITRM1 BAG5 UBA1 COX4I1 SNRPE PSMC1 PAF1 POLR2H MBTPS1 SUMO3 YY1 ARHGDIA RPP38 PSMB4 BANF1 MORF4L2 DRG1 BUD31 RAD23B VPS72 FAM20B CCT2 PPP2R1A PSMC5 LSS NDUFA1 SIVA1 NDUFA2 SETD3 PSMC2 COX7A2L RBM42 COX6B1 CBX3 TECR STX16 CLEC18C ARF5 YWHAE UBR5 COX17 ZC3H14 VCP NDUFB1 SEC13 TMEM147 URM1 IST1 TBCA PSMD9 MRPL9 RAE1 COIL PUF60 SNRPG HSBP1 up
## GNF2_FBL 0.0012887 0.0061414 0.5809257 2.540114 0 133 SRRM1 POLR3E UBE2I RPL13 RPS21 SNRNP200 RPL24 RPS2 RPS3 HDAC1 RPL36 DAP3 RPL10A RPSA TARDBP RPL12 RPL35 SF1 RPL29 SLC7A5P1 RPL22 RPL13A RPS12 NCL RBM15 EIF3D RPL3 SRSF1 RPS15 RRP1B NONO SNRPD3 TCERG1 RPL32 RPL38 NAE1 RPS20 RPS29 BTF3 RPL19 RPL28 RPL9 EIF3L RPL27 RPS8 RPL37 KHDRBS1 RPS7 SNRPD2 TAF1D RPS16 PPIA HINT1 SNRPE RPL8 UTP3 RPL35A HSPA14 RPS4X LSM7 RPS23 RPL14 AIMP1 PPIH APEX1 RPL4 RPL23A POLR1D NSUN5 EEF1B2 COX7C HNRNPF PABPN1 FBL DHX15 RBM12 NUP210 EIF3H KPNB1 RPS6 RPL5 RBMX HNRNPA2B1 PMPCB up
## MODULE_257 0.0012723 0.0061414 0.5689889 2.531817 0 150 RNF40 MUTYH TELO2 NUMA1 URGCP ZNF3 INPPL1 FZR1 CCNL2 PACSIN2 EDC3 AKT1 GABRB1 TLE3 RTKN SRRT PIGQ TSC2 DCTPP1 HPCA DNAJC4 CHPF LRP5 CDC42EP1 MYH7B ARFIP2 TNPO2 ANAPC2 EPS8L2 CPSF7 MKRN1 GPS1 ERF PRPF8 DGCR8 PFKL RAB11B SKI ELL CLSTN1 LRRC61 SHC1 VPS9D1 HMG20B PTTG1IP CAMSAP3 HDAC7 KMT2D PMPCA CHAF1A ABCA7 TSKU OXR1 ATXN2 TNRC6A APLP2 SH3GLB2 MED9 EEF2 MMP15 IMPDH1 DGKZ UBTD1 SNRPA FAT1 RAB35 VPS39 YIF1A MEF2D FBF1 AKT2 STARD3 RARA TAF6L ZDHHC8 SLC35C1 ATP11A SNRNP70 ECE1 HDAC10 PNPLA2 SEC61A1 RBM14 TRA2A MAP4K2 up
## MORF_ARAF1 0.0013793 0.0061414 0.6249824 2.524043 0 73 OTUB1 LMTK2 LYPLA2 PDPK1 FZR1 IGHMBP2 IGSF9B BTBD2 CNTN1 ADAM15 SLC9A1 HSF4 CACTIN PML PCGF2 MTX1 RABGGTA RPLP2 ALDH4A1 GTF2F1 PVT1 HMG20B DHRS1 CIZ1 NELFB MAN2C1 SLC9A3R2 LPAR2 PRKCSH MVK ACKR2 LTK COPS6 RASSF7 GRM4 ARAF B4GALT3 TNK2 TUB SLC12A4 ZFPL1 EML3 GPR35 GRK6 PLIN3 DRG2 CNPPD1 TUBGCP2 STK19 RPS24 MR1 PTMA LGALS9 ARVCF up
## MORF_ACTG1 0.0012920 0.0061414 0.5803588 2.523034 0 127 LYPLA2 UBE2I RPL13 GNAS BTBD2 RPLP0 RPS5 JTB ENO1 RPL24 RPLP1 RPS3 RPL10A RPL18A RPL12 RPL18 SNRPB RPL29 HDGF RPL22 RPL13A RPS12 NCL RPS28 RPL3 RPLP2 RPL11 FAU RPL32 RPS14 RPS11 RPL38 MAZ RPS20 HSP90AB1 RPS29 RPL31 BTF3 SSR2 RPS27 RPL27A RPL19 RPL28 EEF2 RPL9 RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 COX4I1 PPIA RPS15A HINT1 RPL8 RPS4X RPS27A RPL30 SUMO3 RPS23 RPL14 RPL23 RPL4 TAGLN2 RPL23A RPS13 EEF1B2 COX7C JUND UBC ZFPL1 COX8A RPS3A COX5B up
## MORF_RPA2 0.0012422 0.0061414 0.5541835 2.522812 0 176 E2F4 OTUB1 MFN2 SRRM1 TXLNA EIF6 IGSF9B EIF3I CNTN1 ATXN2L SNRNP200 ADAM15 GTF2A2 XPO6 THOP1 OGDH ZMYM4 MEN1 WDR18 FDXR KXD1 MTX1 PRPF8 PARP2 DDX49 AATF ALDH4A1 GTF2F1 NONO CLSTN1 KHNYN SMARCC2 PITPNM1 SFSWAP SREBF2 IMMT NELFB PARN MAP3K11 MCRS1 PRKDC NUDT1 LRPPRC DIAPH1 PRKCSH MVK PKMYT1 RTCB COPS6 COQ9 RPRD2 PMS2P3 PPIE KHDRBS1 CS TCOF1 PSD4 PHB CSNK2A1 B4GALT3 MLEC PSMD2 FANCG RPS6KA3 TAZ RAD54L POLR2A NUP188 DRG1 DDB1 ZNF131 GTF2H3 CASP2 TSFM LSM12 BRD8 ILF2 SMARCD1 PABPN1 ELK1 EML3 TMED9 MCM2 KDM3B ADSL USP19 DNAJC8 SERP1 GRK6 PLIN3 POLA2 AFG3L2 CNPPD1 EIF3M HNRNPA2B1 ABL1 NFRKB NUP62 up
fgsea_plot(fgsea_res$res_c5, pathways_title='C5 GO genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ---------------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 0.0013441 0.0154727 0.6633931 2.833284 0 114 HELZ2 GSPT1 RNPS1 RPL13 EXOSC10 RPS21 RPLP0 RPS5 SMG5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 SMG1 RPL35 RPL29 RPL22 RPL13A UPF3B RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 RPL32 RPS14 RPS11 EIF4G1 PARN RPL38 SMG7 RPS20 RPS29 RPL37A RPL31 DHX34 RPS27 RPL27A RPL19 RPL28 UPF1 RPL9 RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 MAGOH RPL41 RPL23 RPL4 PPP2R1A RPL23A RPS13 up
## GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 0.0012870 0.0154727 0.6340206 2.822039 0 152 MRPL20 MRPS34 RPL13 MRPS18A MRPL55 RPS21 MRPS2 RPLP0P6 RPLP0 MRPS15 RPS5 MRPL14 RPL24 MRPL49 RPS2 RPLP1 RPS3 MRPL28 RPL36 DAP3 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 MRPL17 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 RPL38 MRPS35 MRPL4 RPS20 MRPS33 MRPL12 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 MRPS7 MRPL23 RPL9 MRPL52 MRPS6 MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MRPS23 RPS7 RPL34 MRPL21 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 MRPL10 RPL14 MRPL27 MRPS12 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 MRPL36 up
## GO_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0013624 0.0154727 0.6747627 2.803299 0 94 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 SSR2 RPS27 ZFAND2B RPL27A RPL19 RPL28 RPL9 RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 SRP68 RPL14 SRP54 RPL41 RPL23 RPL4 SEC61A1 RPL23A RPS13 up
## GO_RIBOSOME_BIOGENESIS 0.0011834 0.0154727 0.5883896 2.780204 0 259 NOC2L MRPL20 NOB1 TBL3 NOM1 UTP14A BMS1 RPUSD1 PWP2 EXOSC6 MRTO4 GNL2 NIP7 EIF6 NOC4L TSR3 FAM207A ISG20L2 EXOSC10 PES1 MYBBP1A RPS21 NOP2 MRPS2 RPLP0P6 RPLP0 ERI3 NOP14 MTG2 RPS5 METTL16 WDR55 GEMIN4 MDN1 RRNAD1 NOL6 KRI1 DDX51 RPP25 RPL24 RRP9 RPUSD2 NSUN4 RPS2 NLE1 DHX37 NGDN DDX31 SART1 RSL1D1 RRN3 DDX27 RPL10A WDR18 RRP1 RPSA NOL9 RPL12 ERI1 RPL35 ERAL1 DDX56 EBNA1BP2 VCX LAS1L NOLC1 PELP1 NOP56 RPS28 RPL3 TRMT112 DDX49 AATF RPS15 DROSHA RPL11 RRP1B TFB2M NAT10 TSR1 MRPL11 NVL POP7 RRP7A EXOSC5 URB1 RPS14 IMP4 RPL38 GTPBP4 MALSU1 EXOSC2 DDX54 IMP3 RRS1 URB2 PPAN MPHOSPH10 NUP88 UTP18 ESF1 HEATR1 RPS27 BOP1 PIH1D1 MRPS7 ZNHIT6 RPL27 RPS8 RBFA WDR3 MRPS11 MPV17L2 NPM3 RPS7 DDX28 FTSJ3 RPS16 PAK1IP1 UTP3 RPL35A NHP2 ERCC2 SBDS UTP20 C1QBP RRP15 MRPL10 DHX30 RPL14 RPP38 GNL3L UTP6 GTPBP10 LYAR PA2G4 RPL23A NSUN5 RRP8 BRIX1 MRPL36 FBL XRN2 ZNF622 DDX10 PDCD11 HEATR3 NSUN3 up
## GO_RIBOSOMAL_SUBUNIT 0.0012690 0.0154727 0.6147092 2.767280 0 172 MRPL20 MRPS34 RPL13 MRPS18A MRPL55 RPS21 MRPS2 RPLP0P6 RPLP0 MRPS15 RPS5 MRPL14 RPL24 NSUN4 MRPL49 RPS2 RPLP1 RPS3 NDUFAB1 MRPL28 RPL36 MRPL48 DAP3 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 MRPS26 RPL35 MRPL17 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 RPL38 MRPS35 MALSU1 MRPL4 RPS20 MRPS33 MRPL12 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 MRPS7 MRPL23 RPL9 MRPL52 MRPS6 MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MPV17L2 RPS7 RPL34 MRPL21 RPS16 RPS15A RPS26 FXR2 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 MRPL10 RPL14 MRPL27 C12orf65 MRPS12 RPL39L RPL41 RPL23 MRPS27 RPL4 RPL23A RPS13 MRPL36 MRPL34 RPS3A NSUN3 MRPS5 MRPS28 EIF2D up
## GO_RIBOSOME 0.0012315 0.0154727 0.5959649 2.754003 0 211 AURKAIP1 MRPL20 MRPS34 RPL13 MRPS18A MRPL55 RPS21 MRPS2 RPLP0P6 RPLP0 MRPS15 MTG2 RPS5 MRPL14 RPL24 RRBP1 NSUN4 MRPL49 RPS2 RPLP1 RPS3 NDUFAB1 MRPL28 RPL36 MRPL48 DAP3 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 MRPS26 RPL35 PNPT1 MRPL17 SF1 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 GADD45GIP1 RPL11 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 RPL38 MRPS35 LARP1 DNAJC21 LARP4B MALSU1 MRPL4 RPS20 MRPS33 MRPL12 RPS29 RPL37A RPL31 BTF3 RPS27 RPL27A RPL19 RPL28 DHX9 MRPS7 EEF2 MRPL23 RPL9 MRPL52 MRPS6 MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MPV17L2 MRPS23 RPS7 RPL34 MRPL21 RPS16 RPS15A RPS26 FXR2 RPL8 RPL35A HSPA14 RPS4X RPS27A RPL30 UBA52 RPS23 SRP68 MRPL10 CHCHD1 RPL14 MRPL27 C12orf65 MRPS12 RPL39L PTCD3 RPL41 EIF2AK2 APOD RPL23 MRPS27 APEX1 RPL4 RPL23A RPS13 RPS6KL1 MRPL36 MRPL34 RPS3A METTL17 NSUN3 MRPS5 MRPS28 EIF2D SERP1 EIF3H RPS6 RPL5 RPL26L1 up
## GO_NCRNA_PROCESSING 0.0011377 0.0154727 0.5668328 2.750522 0 325 TYW1 NOB1 PUSL1 TBL3 POLR3K CTU2 UTP14A INTS5 BMS1 RPUSD1 PWP2 EXOSC6 MRTO4 NOC4L TRPT1 TSR3 FAM207A ISG20L2 EXOSC10 PES1 SMAD3 RPS21 METTL3 INTS1 PUS7 NOP2 GTPBP3 TRMT61A ERI3 NOP14 TRMT1 METTL16 WDR55 GEMIN4 SRRT CTU1 MDN1 RRNAD1 NSUN2 NOL6 KRI1 DDX51 TRIT1 RPP25 RRP9 DUS3L RPUSD2 NSUN4 RPS2 TRMU DUS1L DHX37 NGDN SART1 TRMT12 RSL1D1 DDX27 ADAT1 RPL10A WDR18 RRP1 NOL9 ERI1 INTS4 RPL35 TARBP1 DDX56 EBNA1BP2 SEPHS2 USB1 CSTF2 AARS2 ADAR LAS1L NOLC1 DGCR8 PELP1 NOP56 RPS28 MTFMT TRMT112 DDX49 RPS15 DROSHA RPL11 RRP1B TP53RK TFB2M NAT10 TSR1 TRMT44 NVL POP7 RRP7A EXOSC5 URB1 RPS14 METTL1 ANKRD16 PUS1 IMP4 PARN ADAT3 GTPBP4 EXOSC2 DDX54 TRMT5 TRMT11 IMP3 RRS1 CDK5RAP1 MPHOSPH10 RPUSD4 TRMT6 UTP18 ESF1 WDR4 HEATR1 RPS27 BOP1 PIH1D1 CPSF4 RTCB RNF113A ZNHIT6 RPL27 ZBTB8OS RPS8 RBFA QTRT1 WDR3 MRPS11 TSEN54 NPM3 RPS7 KTI12 LCMT2 AGO2 FTSJ3 GRSF1 FARS2 RPS16 UTP3 RPL35A NHP2 METTL2B AGO1 ERCC2 INTS7 SBDS UTP20 DUS2 RRP15 MOCS3 RPL14 RPP38 TUT1 up
## GO_RIBOSOME_ASSEMBLY 0.0014535 0.0154727 0.7300998 2.750222 0 52 MRPL20 PWP2 MRTO4 NIP7 EIF6 NOP2 MRPS2 RPLP0P6 RPLP0 RPS5 MDN1 RPL24 NSUN4 NLE1 RPSA RPL12 ERAL1 VCX RPS28 RPL3 RPS15 RPL11 MRPL11 RRP7A RPS14 RPL38 RRS1 PPAN RPS27 BOP1 MRPS7 MRPS11 MPV17L2 DDX28 SBDS C1QBP DHX30 up
## GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 0.0011148 0.0154727 0.5593237 2.745922 0 382 NOC2L MRPL20 EIF3B NOB1 TBL3 USP39 PRPF6 NOM1 CD2BP2 UTP14A BMS1 RPUSD1 PWP2 EXOSC6 MRTO4 GNL2 NIP7 EIF6 NOC4L TSR3 FAM207A ISG20L2 EXOSC10 PES1 EIF3I MYBBP1A RPS21 NOP2 SF3A2 MRPS2 RPLP0P6 RPLP0 SNRNP200 ERI3 NOP14 MTG2 RPS5 METTL16 WDR55 GEMIN4 MDN1 RRNAD1 NOL6 KRI1 DDX51 XAB2 RPP25 RPL24 RRP9 PRMT7 RPUSD2 NSUN4 RPS2 NLE1 DHX37 NGDN DDX31 SART1 RSL1D1 RRN3 DDX27 RPL10A WDR18 RRP1 RPSA CLNS1A NOL9 CPSF7 RPL12 ERI1 LUC7L EIF3C RPL35 ERAL1 SF1 SNRPB PRMT5 DDX56 EBNA1BP2 VCX SRPK1 RPL13A DDX23 ADAR PRPF8 LAS1L NOLC1 PELP1 NOP56 RPS28 EIF3D RPL3 TRMT112 SRSF1 DDX49 AATF RPS15 PRPF19 RUVBL1 DROSHA RPL11 RUVBL2 RRP1B SF3A3 TFB2M NAT10 TSR1 SNRPD3 EIF3CL PRPF39 MRPL11 NVL CELF1 POP7 RRP7A EXOSC5 URB1 RPS14 SFSWAP PRPF18 TXNL4A IMP4 LSM4 RPL38 EIF3G GTPBP4 MALSU1 EXOSC2 DDX54 IMP3 RRS1 AAR2 URB2 CELF5 PPAN HSP90AB1 MPHOSPH10 NUP88 UTP18 ESF1 HEATR1 RPS27 BOP1 PIH1D1 DHX9 MRPS7 SF3A1 EIF3L ZNHIT6 WDR77 GEMIN8 RPL27 RPS8 RBFA WDR3 MRPS11 MPV17L2 NOL3 NPM3 RPS7 DDX28 AGO2 FTSJ3 CELF4 SNRPD2 RPS16 PAK1IP1 SNRPE UTP3 RPL35A NHP2 SRPK2 AGO1 ERCC2 SBDS UTP20 C1QBP RRP15 MRPL10 DHX30 RPL14 RPP38 SART3 GNL3L UTP6 GTPBP10 SNRPC LYAR PA2G4 GEMIN5 TARBP2 RPL23A NSUN5 RRP8 BRIX1 GEMIN6 MRPL36 FBL XRN2 ZNF622 SRSF9 up
## GO_CYTOSOLIC_RIBOSOME 0.0013680 0.0154727 0.6498064 2.702640 0 95 RPL13 RPS21 RPLP0P6 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 FXR2 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL39L RPL41 APOD RPL23 RPL4 RPL23A RPS13 up
## GO_LARGE_RIBOSOMAL_SUBUNIT 0.0013495 0.0154727 0.6357081 2.695896 0 108 MRPL20 RPL13 MRPS18A MRPL55 RPLP0P6 RPLP0 MRPL14 RPL24 NSUN4 MRPL49 RPLP1 NDUFAB1 MRPL28 RPL36 MRPL48 RPL10A RPL39 RPL18A RPL12 RPL18 RPL35 MRPL17 RPL29 RPL22 RPL13A RPL3 RPLP2 RPL11 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPL38 MALSU1 MRPL4 MRPL12 RPL37A RPL31 RPL27A RPL19 RPL28 MRPL23 RPL9 MRPL52 MRPL33 MRPL51 RPL36AL RPL27 RPL37 MRPL54 MPV17L2 RPL34 MRPL21 FXR2 RPL8 RPL35A RPL30 UBA52 MRPL10 RPL14 MRPL27 C12orf65 RPL39L RPL41 RPL23 RPL4 RPL23A MRPL36 MRPL34 up
## GO_NCRNA_METABOLIC_PROCESS 0.0011086 0.0154727 0.5459499 2.688157 0 396 MAEL TYW1 TDRD1 NOB1 PUSL1 TBL3 POLR3K CTU2 UTP14A INTS5 BMS1 RPUSD1 PWP2 EXOSC6 MRTO4 NOC4L TRPT1 TSR3 FAM207A ISG20L2 EXOSC10 PES1 SMAD3 RPS21 METTL3 INTS1 PUS7 NOP2 GTPBP3 DIS3L2 EARS2 FARSB AIMP2 TRMT61A XPO5 NARS2 ERI3 NOP14 TRMT1 METTL16 WDR55 GEMIN4 SRRT GPAT2 CTU1 MDN1 RRNAD1 NSUN2 NOL6 KRI1 DDX51 TRIT1 RPP25 RRP9 DUS3L RPUSD2 NSUN4 RPS2 TRMU DUS1L DHX37 HRAS NGDN SART1 TRMT12 RSL1D1 DDX27 ADAT1 RELA RPL10A WDR18 FARSA RRP1 NOL9 ERI1 INTS4 RPL35 PNPT1 TARBP1 DDX56 EBNA1BP2 SEPHS2 USB1 CSTF2 AARS2 ADAR LAS1L NOLC1 DGCR8 PELP1 NOP56 RPS28 MTFMT TRMT112 DDX49 RPS15 DROSHA RPL11 RRP1B TP53RK TFB2M NAT10 TSR1 TRMT44 NVL POP7 RRP7A EXOSC5 URB1 RPS14 METTL1 ANKRD16 MEPCE PUS1 IMP4 PARN KHSRP ADAT3 ZC3H12A GTPBP4 EXOSC2 DDX54 TRMT5 TRMT11 IMP3 RRS1 CDK5RAP1 MARS2 HARS2 MPHOSPH10 RPUSD4 TRMT6 UTP18 ESF1 WDR4 HEATR1 RPS27 BOP1 PIH1D1 TARS2 CPSF4 RTCB DIS3L RNF113A ZNHIT6 RPL27 ZBTB8OS RPS8 RBFA QTRT1 WDR3 MRPS11 TSEN54 NPM3 RPS7 KTI12 LCMT2 AGO2 FTSJ3 GRSF1 FARS2 RPS16 PELO SND1 UTP3 RPL35A NHP2 DTD1 METTL2B AGO1 ERCC2 INTS7 SBDS UTP20 RC3H1 DUS2 RRP15 MOCS3 RPL14 PPA1 SARS2 RPP38 TUT1 ELAC2 AIMP1 UTP6 SLFN13 LYAR YARS2 PA2G4 SEPHS1 TARBP2 NSUN5 TRMT2B RRP8 PTCD1 TSEN2 DDX4 FBL XRN2 AARSD1 DDX10 POP1 IARS2 PDCD11 up
## GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS 0.0012484 0.0154727 0.5886189 2.680741 0 189 EDC4 THRAP3 HELZ2 GSPT1 RNPS1 EXOSC6 MRTO4 RPL13 EDC3 EXOSC10 RPS21 DIS3L2 RPLP0 GTPBP2 RPS5 SMG5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA LSM5 RPL18A RPL12 RPL18 SMG1 RPL35 RPL29 TNKS1BP1 RPL22 RPL13A UPF3B RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 RPL32 EXOSC5 RPS14 RPS11 PRPF18 EIF4G1 LSM4 PARN RPL38 SMG7 ZC3H12A DCPS EXOSC2 RPS20 RPS29 RPL37A RPL31 DHX34 RPS27 TNRC6A RPL27A RPL19 RPL28 UPF1 RPL9 PAN2 SAMD4B RPL27 RPS8 RPL37 CNOT11 RPS7 AGO2 RPL34 SAMD4A RPS16 PELO RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A AGO1 RPL30 UBA52 LSM7 RC3H1 RPS23 RPL14 MAGOH RPL41 RPL23 RPL4 PPP2R1A RPL23A RPS13 up
## GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 0.0013158 0.0154727 0.6165718 2.677920 0 128 ANKRD13C RER1 DDRGK1 RPL13 RPS21 PMM2 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 KDELR2 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 CHMP4B RPL11 OS9 PDIA2 RPL32 RPS14 RPS11 SGTA RPL38 SEC16A RPS20 RPS29 RPL37A RPL31 RPS27 ZFAND2B RPL27A RPL19 RPL28 TAPT1 RPL9 SEC61G RPL27 RPS8 RPL37 RPS7 GRIK5 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 SRP68 RPL14 SRP54 RAB3GAP2 RPL41 RPL23 GBF1 RPL4 SEC61A1 RPL23A LRRK2 RPS13 up
## GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT 0.0014514 0.0154727 0.7046663 2.667882 0 53 RPL13 RPLP0P6 RPLP0 RPL24 RPLP1 RPL36 RPL10A RPL39 RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPL3 RPLP2 RPL11 RPL32 RPL38 RPL37A RPL31 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPL37 RPL34 FXR2 RPL8 RPL35A RPL30 UBA52 RPL14 RPL39L RPL41 RPL23 RPL4 RPL23A up
## GO_RIBONUCLEOPROTEIN_COMPLEX 0.0010571 0.0154727 0.5272384 2.666200 0 630 NOC2L SNORA74A MRPL20 SNRNP25 EIF3B NOB1 TBL3 SRRM1 GTF3C1 USP39 MRPS34 PRPF6 SRRM2 CD2BP2 UTP14A BMS1 PWP2 MRTO4 SF3B3 NIP7 EIF6 RPL13 IGHMBP2 NOC4L MRPS18A FAM207A ZNF830 CWC25 PES1 EIF3I MRPL55 RPS21 TERC DIS3L2 SF3A2 MRPS2 MKRN3 RPLP0P6 RPLP0 XPO5 SNRNP200 NOP14 MRPS15 RPS5 RMRP GEMIN4 RBMX2 SMG5 NOL6 KRI1 MRPL14 XAB2 RPP25 RPL24 RRP9 DDX41 NSUN4 MRPL49 RPS2 RPLP1 RPS3 NDUFAB1 CACTIN MRPL28 NGDN DHX38 SART1 RSL1D1 RPL36 MRPL48 RNPC3 DAP3 RPL10A RPL39 RRP1 RPSA LSM5 TARDBP PPP1R8 RPL18A RPL12 RPL18 ERI1 LUC7L MRPS26 AKAP8L EIF3C RPL35 PNPT1 MRPL17 SF1 SNRPB RPL29 EBNA1BP2 RPL22 RPL13A DDX23 ADAR PRPF8 LAS1L NOLC1 RPS12 NCL NOP56 DHX29 RPS28 CSNK1A1 DDX53 EIF3D RPL3 SRSF1 HTATSF1 ILF3 TFIP11 RPLP2 RPS15 PRPF19 RUVBL1 PKP3 RPL11 RUVBL2 HNRNPAB RRP1B SF3B2 SF3A3 NAT10 TSR1 SNRPD3 MRPL24 EIF3CL PRPF39 MRPL11 U2AF2 NVL RPL32 CELF1 MRPL41 POP7 RRP7A MRPL37 PSMA6 RPS14 PABPC1L CDC5L RPS11 PRPF18 EIF4G1 SNIP1 TXNL4A ALYREF IMP4 LSM4 RPL38 MRPS35 EIF3G LARP1 SMG7 MCRS1 LARP4B FBXW9 MALSU1 FUS RALY MRPL4 RPS20 IMP3 MRPS33 SNRNP40 RRS1 ACTN4 AAR2 SLBP MRPL12 CELF5 PPAN LRPPRC RPS29 MPHOSPH10 RPL37A UTP18 RPL31 WDR83 PHF5A BTF3 ATXN2 HEATR1 RPS27 BOP1 DAZAP1 TNRC6A PIH1D1 RPL27A RPL19 RPL28 DHX9 MRPS7 UPF1 EEF2 ELAVL1 SF3A1 MRPL23 RPL9 MRPL52 EIF3L MRPS6 RNF113A ZNHIT6 MRPL33 MRPL51 PPIE RPL36AL RPL27 SNRNP35 RPS8 RPL37 SREK1 WDR3 MRPS11 MRPL54 ZMAT5 MPV17L2 RBM28 RPS7 MSI1 SNRPA AGO2 FTSJ3 CELF4 PABPC4 RPL34 EFTUD2 MFAP1 SNRPD2 MRPL21 RPS16 EEFSEC RPS15A RPS26 SND1 SNRPE FXR2 TRIM21 RPL8 UTP3 RPL35A HSPA14 NHP2 RPS4X RPS27A LSM10 MYEF2 AGO1 RPL30 UBA52 LSM7 UTP20 RPS23 SNRNP70 RRP15 SRP68 MRPL10 MSI2 RPL14 MRPL27 RPP38 SRP54 C12orf65 SART3 DRG1 GNL3L BUD31 UTP6 MRPS12 CCDC12 RPL39L MAGOH PPIH BUD13 RPL41 SNRPC RPL23 MRPS27 IGF2BP1 RPL4 TERT PRPF38A DHX8 RBM14 TRA2A TARBP2 RPL23A LRRK2 RPS13 ILF2 HNRNPF MRPL36 RBM17 PABPN1 FBL ZNF622 DHX15 ZFP36L1 MRPL34 SUGP1 POP1 PDCD11 RPS3A NUP98 SRA1 NSUN3 MRPS5 MRPS28 HNRNPU EIF2D TEP1 RBM42 SF3B5 ZMAT2 EIF3H GAR1 NOL10 PDCD7 EIF3A JAKMIP1 RPS6 PABPC3 RPL5 RPL26L1 EIF3M RBMX HNRNPA2B1 SMG6 MRPL3 EIF2AK4 GAPDH NOP58 PRPF4 HNRNPM MRPS30 HNRNPA1 SNRPB2 RPS24 LGALS3 NUP62 ZC3H14 NOP10 up
## GO_VIRAL_GENE_EXPRESSION 0.0012531 0.0154727 0.5859487 2.663967 0 185 EIF3B SMARCA4 RPL13 RSF1 RPS21 PTBP1 RPLP0 RPS5 NELFCD RPL24 RPS2 RPLP1 RPS3 NELFA HDAC1 RPL36 PSMC3 RPL10A RPL39 RPSA TARDBP EP300 RPL18A RPL12 RPL18 TRIM11 RPL35 RPL29 TRIM62 POLR2L POLR2J RPL22 RPL13A RPS12 RPS28 EIF3D RPL3 NUP93 RPLP2 RPS15 NUP205 RPL11 RRP1B GTF2F1 RPL32 RPS14 RPS11 POLR2E NELFB RPL38 EIF3G CTDP1 INPP5K RPS20 RPS29 NUP88 RPL37A RPL31 SUPT5H TPR POLR2C RPS27 SMARCB1 RPL27A RPL19 RPL28 TFAP4 DHX9 USF1 POLR2F RPL9 EIF3L MID2 NUP160 RPL27 RPS8 RPL37 NUP214 MON1B RPS7 RPL34 NUP133 RPS16 RPS15A RPS26 TRIM21 RPL8 RPL35A POLR2H RPS4X RPS27A RPL30 POU2F3 UBA52 RPS23 RPL14 POLR2A NUP188 NUP85 RPL41 RPL23 RPL4 TARBP2 RPL23A RPS13 RPS3A NUP98 NUP107 NUP210 EIF2D POM121C AAAS EIF3A POLR2I RPS6 RPL5 NUP50 TRIM14 EIF2AK4 RPS24 NUP62 CDK9 up
## GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 0.0013532 0.0154727 0.6301622 2.662876 0 106 RPL13 RPS21 PMM2 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 CHMP4B RPL11 RPL32 RPS14 RPS11 SGTA RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 ZFAND2B RPL27A RPL19 RPL28 RPL9 SEC61G RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 SRP68 RPL14 SRP54 RAB3GAP2 RPL41 RPL23 RPL4 SEC61A1 RPL23A RPS13 up
## GO_RRNA_METABOLIC_PROCESS 0.0012547 0.0154727 0.5782015 2.642932 0 195 NOB1 TBL3 UTP14A BMS1 RPUSD1 PWP2 EXOSC6 MRTO4 NOC4L TSR3 FAM207A ISG20L2 EXOSC10 PES1 RPS21 NOP2 ERI3 NOP14 METTL16 WDR55 GEMIN4 MDN1 RRNAD1 NOL6 KRI1 DDX51 RPP25 RRP9 RPUSD2 NSUN4 RPS2 DHX37 NGDN SART1 RSL1D1 DDX27 RPL10A WDR18 RRP1 NOL9 ERI1 RPL35 DDX56 EBNA1BP2 LAS1L NOLC1 PELP1 NOP56 RPS28 TRMT112 DDX49 RPS15 DROSHA RPL11 RRP1B TFB2M NAT10 TSR1 NVL POP7 RRP7A EXOSC5 URB1 RPS14 IMP4 GTPBP4 EXOSC2 DDX54 IMP3 RRS1 MPHOSPH10 UTP18 ESF1 HEATR1 RPS27 BOP1 PIH1D1 DIS3L ZNHIT6 RPL27 RPS8 RBFA WDR3 MRPS11 NPM3 RPS7 FTSJ3 RPS16 PELO UTP3 RPL35A NHP2 ERCC2 SBDS UTP20 RRP15 RPL14 RPP38 UTP6 SLFN13 LYAR PA2G4 up
## GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 0.0014124 0.0154727 0.6659731 2.607966 0 62 NOC2L MRPL20 MRTO4 NIP7 EIF6 PES1 NOP2 RPLP0P6 RPLP0 MDN1 RPL24 NLE1 RSL1D1 RPL10A NOL9 RPL12 RPL35 EBNA1BP2 LAS1L RPL3 RPL11 MRPL11 NVL URB1 RPL38 GTPBP4 MALSU1 RRS1 PPAN BOP1 ZNHIT6 DDX28 FTSJ3 PAK1IP1 RPL35A NHP2 DHX30 RPL14 up
## GO_PRERIBOSOME 0.0014124 0.0154727 0.6457782 2.579780 0 71 NOC2L NOB1 TBL3 UTP14A BMS1 PWP2 MRTO4 NIP7 EIF6 NOC4L FAM207A PES1 NOP14 NOL6 KRI1 RRP9 NGDN RSL1D1 RRP1 EBNA1BP2 LAS1L NOP56 RRP1B TSR1 RRP7A IMP4 FBXW9 IMP3 RRS1 PPAN MPHOSPH10 UTP18 HEATR1 BOP1 WDR3 RPS7 FTSJ3 UTP3 UTP20 RRP15 UTP6 up
## GO_MITOCHONDRIAL_PROTEIN_COMPLEX 0.0012195 0.0154727 0.5565086 2.579706 0 217 DNAJC11 MRPL20 MRPS34 MRPS18A MRPL55 FOXRED1 MRPS2 MRPS15 MCU NDUFB10 MRPL14 MT-CYB MICU1 NSUN4 MRPL49 CHCHD3 NDUFAB1 MRPL28 SDHB AGK MRPL48 MT-ND3 SDHA DAP3 POLRMT SPG7 MT-ND4L MTX1 MRPS26 BCKDK NDUFB2 PNPT1 MRPL17 NDUFS6 GRPEL1 UQCRC2 MT-ND5 NDUFV1 MRPL24 MRPL11 MCCC1 NDUFS3 MT-CO1 NDUFB7 MRPL41 MT-ATP6 MRPL37 CHCHD10 IMMT TOMM40 TOMM22 MRPS35 CLPX POLG MT-ND4 MALSU1 PMPCA TIMM9 MRPL4 MRPS33 MRPL12 TIMM8B MT-ND2 NDUFS8 TIMM13 ANKZF1 BAX NDUFS4 CYC1 NDUFS5 MRPS7 ROMO1 NDUFA13 MRPL23 MRPL52 UQCR10 TIMM22 MRPS6 TOMM7 MRPL33 MRPL51 NDUFA4 COA3 TOMM20 MRPS11 MRPL54 MPV17L2 TIMM50 UQCRH MCCC2 MRPL21 COX4I1 MT-ND1 BCS1L NDUFB9 MT-ATP8 UQCRQ MRPL10 MRPL27 TIMM10 C12orf65 MRPS12 NDUFS7 NDUFC1 MRPS27 CHCHD6 NDUFC2 NDUFA10 NDUFA1 MRPL36 VDAC1 MRPL34 NDUFA2 COX6A2 NSUN3 MRPS5 MRPS28 NDUFS2 NDUFA11 IMMP2L MTX2 AFG3L2 BCKDHB PMPCB SUPV3L1 MRPL3 up
## GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION 0.0012500 0.0154727 0.5683300 2.575484 0 177 MRPL20 EIF3B USP39 PRPF6 CD2BP2 PWP2 MRTO4 EIF6 EIF3I NOP2 SF3A2 RPLP0P6 RPLP0 SNRNP200 RPS5 GEMIN4 MDN1 XAB2 RPL24 PRMT7 NLE1 SART1 RPSA CLNS1A CPSF7 RPL12 LUC7L EIF3C ERAL1 SF1 SNRPB PRMT5 SRPK1 RPL13A DDX23 ADAR PRPF8 RPS28 EIF3D RPL3 SRSF1 TFIP11 RPS15 PRPF19 RUVBL1 RPL11 RUVBL2 SF3A3 SNRPD3 EIF3CL PRPF39 MRPL11 CELF1 RRP7A RPS14 SFSWAP PRPF18 TXNL4A LSM4 RPL38 EIF3G RRS1 AAR2 CELF5 PPAN HSP90AB1 RPS27 BOP1 PIH1D1 DHX9 MRPS7 SF3A1 EIF3L ZNHIT6 WDR77 GEMIN8 MRPS11 NOL3 DDX28 AGO2 CELF4 SNRPD2 SNRPE SRPK2 AGO1 DHX30 SART3 SNRPC GEMIN5 DHX8 TARBP2 RPL23A BRIX1 ZFAND1 GEMIN6 up
## GO_RNA_PROCESSING 0.0010331 0.0154727 0.5044476 2.569162 0 817 TYW1 SSU72 CDK13 SRSF4 AURKAIP1 RNF40 THRAP3 SNRNP25 CDK11B NOB1 PUSL1 TBL3 POLR3K CTU2 SRRM1 RNPS1 TBRG4 USP39 PRPF6 SRRM2 MNAT1 SLTM CD2BP2 UTP14A INTS5 BMS1 RPUSD1 PWP2 RP9 EXOSC6 MRTO4 SF3B3 FASTK NOC4L TRPT1 ZC3H7A CLK3 TSR3 FAM207A ISG20L2 ZNF830 EXOSC10 CWC25 PES1 SMAD3 CHERP RPS21 METTL3 INTS1 PUS7 NOP2 GTPBP3 CDK11A SF3A2 PTBP1 TRMT61A SNRNP200 ERI3 NOP14 RMRP TRMT1 METTL16 WDR55 ZC3H7B CMTR1 GEMIN4 SRRT CTU1 RBMX2 FASTKD5 THOC6 MDN1 RRNAD1 NSUN2 NOL6 KRI1 DDX51 TRIT1 XAB2 RPP25 RRP9 PUM1 PRMT7 DUS3L DDX41 RPUSD2 NSUN4 RPS2 TRMU DUS1L CACTIN DHX37 SCAF1 NGDN DHX38 PHRF1 SART1 TRMT12 RSL1D1 DDX27 ADAT1 RNPC3 RPL10A WDR18 RRP1 LSM5 PRCC TARDBP MAP2K2 PPP1R8 CLNS1A NOL9 IWS1 CPSF7 ERI1 LUC7L EGFR AKAP8L INTS4 RPL35 PNPT1 AHCYL1 SF1 SNRPB TARBP1 PRMT5 DDX56 HABP4 EBNA1BP2 POLR2L CCAR2 SEPHS2 ESRP2 SRPK1 POLR2J SUPT6H USB1 CSTF2 LEO1 DDX23 AARS2 ADAR PRPF8 LAS1L NOLC1 UPF3B ACIN1 DGCR8 NCL PELP1 NOP56 RPS28 RBM15 MTFMT TRMT112 ZMPSTE24 SRSF1 HTATSF1 DDX49 TFIP11 RPS15 PRPF19 DROSHA RPRD1B RPL11 RRP1B TP53RK SF3B2 NCOR2 SF3A3 ZBTB7A GTF2F1 TFB2M NONO NAT10 TSR1 SNRPD3 DDX46 PRPF39 U2AF2 TRMT44 NVL CDK12 CELF1 CLASRP POP7 RRP7A EXOSC5 URB1 RPS14 PABPC1L CDC5L METTL1 ANKRD16 SFSWAP PRPF18 POLR2E SNIP1 TXNL4A ALYREF PUS1 IMP4 POLDIP3 LSM4 PARN KHSRP ADAT3 ZC3H12A GTPBP4 DCPS EXOSC2 DDX54 MAP2K1 FUS TRMT5 RALY TRMT11 TRMT2A A1CF IMP3 SNRNP40 HNRNPUL1 RRS1 CDK5RAP1 AAR2 SLBP CELF5 APP MPHOSPH10 RPUSD4 TRMT6 UTP18 ZC3H3 WDR83 DDX39A ESF1 PHF5A WDR4 SUPT5H POLR2C HEATR1 RPS27 BOP1 DAZAP1 SUGP2 PIH1D1 TP53 TSN DHX9 CPSF4 POLR2F ELAVL1 SF3A1 RTCB PAN2 RPRD2 RNF113A ZNHIT6 RBPMS WDR77 WDR33 PPIE GEMIN8 RPL27 SNRNP35 ZBTB8OS RPS8 RBFA SREK1 QTRT1 WDR3 DDX42 MRPS11 KHDRBS1 TSEN54 ZMAT5 RBM28 NOL3 NPM3 RPS7 SON ESRP1 SNRPA KTI12 LCMT2 AGO2 FTSJ3 CELF4 PABPC4 EFTUD2 MFAP1 GRSF1 SNRPD2 PCF11 FARS2 RPS16 KDM1A RPS26 SNRPE FXR2 UTP3 RPL35A PAF1 SCNM1 NHP2 METTL2B POLR2H SRPK2 LSM10 AGO1 ERCC2 SAFB2 INTS7 ERN1 SBDS LSM7 UTP20 C1QBP RBM19 SNRNP70 DUS2 RRP15 MOCS3 RPL14 RPP38 TUT1 POLR2A PPP1R9B SART3 ELAC2 BUD31 UTP6 THOC2 MAGOH PPIH BUD13 SNRPC LYAR GTF2H3 PA2G4 ERCC3 ADARB2 GEMIN5 PPP2R1A TERT SEPHS1 PRPF38A DHX8 TRA2A TARBP2 ALKBH5 NSUN5 TRMT2B RRP8 RPS13 GEMIN6 PTCD1 HNRNPF RBM17 TSEN2 PABPN1 HNRNPLL SAFB SFPQ FBL XRN2 MYCN SRSF9 DHX15 ZFP36L1 SUGP1 DDX10 POP1 PDCD11 NUP98 TRUB2 SYMPK CSTF1 NSUN3 APOBEC1 HNRNPU RNASEL CCAR1 PUS3 RBM42 DNAJC8 THOC3 ZC3H11A TSR2 SF3B5 ZMAT2 GAR1 up
## GO_PROTEIN_TARGETING_TO_MEMBRANE 0.0012579 0.0154727 0.5669637 2.555784 0 173 ZDHHC4 TAOK2 RPL13 RPS21 CDK5 MYO1C ZDHHC11B RPLP0 CIB1 ICMT RPS5 PEX16 ANK3 RPL24 RPS2 ZDHHC11 RPLP1 HPCA RPS3 HRAS VPS37B RPL36 ZDHHC9 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 ZDHHC7 RPL3 RPLP2 RPS15 CHMP4B RPL11 PAK1 ZDHHC12 RPL32 RPS14 RPS11 DMTN FIS1 VPS37C ERBB2 SGTA RPL38 ZDHHC1 MICALL1 INPP5K RPS20 RPS29 RPL37A RPL31 GDI1 SSR2 RPS27 ZFAND2B RPL27A RPL19 RPL28 RPL9 RPL27 RPS8 RPL37 RPS7 RPL34 EXOC4 PARD3 RPS16 AKT2 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 RTP4 UBA52 MIEF2 RPS23 SRP68 RPL14 SRP54 RPL41 RPL23 RPL4 SEC61A1 RPL23A RPS13 up
## GO_RRNA_BINDING 0.0014388 0.0154727 0.6702524 2.555215 0 55 MRPL20 MRPS18A RPLP0P6 RPLP0 RPS5 FASTKD5 NSUN4 RPS3 RPL12 ERI1 ERAL1 RPL3 RPL11 MRPL11 RPS14 RPS11 IMP3 RRS1 MRPS7 EEF2 RPL9 MRPS6 RPL37 MRPS11 DDX28 RPL8 RPS4X SBDS NOL12 PTCD3 RPL23 MRPS27 TST RPL23A ANG RPS13 up
## GO_RNA_CATABOLIC_PROCESS 0.0011173 0.0154727 0.5167342 2.529231 0 366 EDC4 THRAP3 HELZ2 CARHSP1 PSMC6 GSPT1 RNPS1 MTOR TBRG4 YTHDF2 PLEKHN1 EXOSC6 MRTO4 RPL13 EDC3 EXOSC10 AKT1 RPS21 METTL3 DIS3L2 RPLP0 GTPBP1 GTPBP2 RPS5 METTL16 PSMD3 MEX3D SMG5 RPL24 PUM1 RPS2 RPLP1 RPS3 PSMB2 PSMD11 RPL36 PSMC3 TIRAP RPL10A RPL39 RPSA PSMA5 LSM5 TARDBP PPP1R8 FEN1 RPL18A RPL12 RPL18 SMG1 RPL35 PNPT1 RPL29 PSMA7 TNKS1BP1 RPL22 STK31 RPL13A UPF3B RPS12 MOV10 RPS28 RPL3 ZHX2 RPLP2 RPS15 DROSHA PKP3 RPL11 NUDT12 PSME2 RPL32 EXOSC5 PSMA6 RPS14 RPS11 PRPF18 EIF4G1 PSMB5 LSM4 PARN RPL38 KHSRP LARP1 SMG7 ZC3H12A DCPS EXOSC2 PSMA3 RNASEH1 FUS PAIP1 RPS20 PRKCA PSMB10 LRPPRC RPS29 RPL37A OAS2 RPL31 E2F1 DHX34 RPS27 TNRC6A RPL27A RPL19 RPL28 DHX9 PSMC4 UPF1 ELAVL1 GIGYF2 RPL9 DIS3L PAN2 SAMD4B PSMD4 PSMF1 RPL27 RPS8 RPL37 NUP214 CNOT11 RPS7 NRDE2 PSME3 AGO2 PABPC4 RPL34 GRSF1 SAMD4A RNH1 RPS16 PELO RPS15A RPS26 AEN SND1 FXR2 PSMC1 RPL8 RPL35A RPS4X RPS27A PSMD12 MYEF2 AGO1 RPL30 PSMD2 UBA52 ERN1 LSM7 RC3H1 RPS23 RPL14 PSMD13 PSMB4 SLFN13 MAGOH RPL41 RPL23 IGF2BP3 IGF2BP1 APEX1 RPL4 PPP2R1A PSMC5 ALKBH5 RPL23A RPS13 RNASEH2C UBC ANP32A XRN2 ZFP36L1 POP1 RPS3A PSMB3 PSMC2 APOBEC1 HNRNPU up
## GO_MRNA_METABOLIC_PROCESS 0.0010460 0.0154727 0.4946773 2.511961 0 763 SSU72 CDK13 SRSF4 AURKAIP1 RNF40 EDC4 THRAP3 SNRNP25 HELZ2 CDK11B CARHSP1 PSMC6 GSPT1 SRRM1 RNPS1 MTOR TBRG4 USP39 PRPF6 SRRM2 MNAT1 SLTM CD2BP2 YTHDF2 PLEKHN1 EXOSC6 MRTO4 SF3B3 RPL13 EDC3 ZNF830 EXOSC10 CWC25 CHERP AKT1 RPS21 METTL3 PUS7 DIS3L2 CDK11A SF3A2 PTBP1 TRMT61A RPLP0 GTPBP1 SNRNP200 GTPBP2 RPS5 METTL16 CMTR1 GEMIN4 SRRT PSMD3 RBMX2 FASTKD5 MEX3D THOC6 SMG5 XAB2 RPL24 PUM1 PRMT7 DDX41 RPS2 RPLP1 RPS3 CACTIN PSMB2 PSMD11 SCAF1 DHX38 PHRF1 SART1 RPL36 PSMC3 TIRAP RNPC3 RPL10A RPL39 RPSA PSMA5 LSM5 PRCC TARDBP PPP1R8 CLNS1A RPL18A IWS1 CPSF7 RPL12 RPL18 SMG1 LUC7L AKAP8L RPL35 PNPT1 AHCYL1 SF1 SNRPB PRMT5 RPL29 HABP4 POLR2L PSMA7 CCAR2 ESRP2 SRPK1 POLR2J SUPT6H TNKS1BP1 CSTF2 RPL22 LEO1 RPL13A DDX23 ADAR PRPF8 UPF3B ACIN1 RPS12 NCL MOV10 RPS28 RBM15 RPL3 ZHX2 SRSF1 HTATSF1 TFIP11 RPLP2 DDIT3 RPS15 PRPF19 RPRD1B PKP3 RPL11 RRP1B SF3B2 SF3A3 ZBTB7A GTF2F1 NONO FOXE3 SNRPD3 DDX46 PRPF39 U2AF2 NUDT12 CDK12 PSME2 RPL32 CELF1 CLASRP EXOSC5 PSMA6 RPS14 PABPC1L CDC5L RPS11 SFSWAP PRPF18 EIF4G1 POLR2E SNIP1 TXNL4A PSMB5 ALYREF PUS1 POLDIP3 LSM4 PARN RPL38 KHSRP LARP1 SMG7 ZC3H12A DCPS EXOSC2 PSMA3 FUS RALY PAIP1 RPS20 PRKCA A1CF SNRNP40 HNRNPUL1 AAR2 SLBP CELF5 APP PSMB10 RPS29 PCIF1 TRMT6 RPL37A ZC3H3 RPL31 WDR83 DDX39A PHF5A E2F1 DHX34 SUPT5H POLR2C RPS27 DAZAP1 TNRC6A SUGP2 PPARD TP53 RPL27A RPL19 RPL28 DHX9 PSMC4 CPSF4 UPF1 POLR2F ELAVL1 SF3A1 GIGYF2 RPL9 PAN2 SAMD4B RPRD2 RNF113A PSMD4 WDR77 WDR33 PPIE GEMIN8 PSMF1 RPL27 SNRNP35 RPS8 RPL37 NUP214 SREK1 DDX42 CNOT11 KHDRBS1 TSEN54 ZMAT5 RBM28 NOL3 RPS7 SON PSME3 ESRP1 SNRPA AGO2 CELF4 PABPC4 RPL34 EFTUD2 MFAP1 GRSF1 SNRPD2 SAMD4A PCF11 RNH1 RPS16 KDM1A PELO RPS15A RPS26 SNRPE FXR2 PSMC1 RPL8 RPL35A PAF1 SCNM1 POLR2H RPS4X RPS27A SRPK2 LSM10 PSMD12 MYEF2 AGO1 ERCC2 RPL30 SAFB2 PSMD2 UBA52 ERN1 LSM7 C1QBP RC3H1 RBM19 RPS23 SNRNP70 RPL14 PSMD13 PSMB4 TUT1 POLR2A SART3 BUD31 THOC2 MAGOH PPIH BUD13 RPL41 SNRPC RPL23 IGF2BP3 GTF2H3 ERCC3 ADARB2 IGF2BP1 APEX1 GEMIN5 RPL4 PPP2R1A PRPF38A DHX8 PSMC5 TRA2A ALKBH5 RPL23A RPS13 GEMIN6 HNRNPF RBM17 UBC TSEN2 PABPN1 HNRNPLL SAFB SFPQ ANP32A XRN2 SRSF9 ATF4 DHX15 ZFP36L1 SUGP1 PDCD11 RPS3A PSMB3 NUP98 TRUB2 SYMPK CSTF1 PSMC2 APOBEC1 HNRNPU RNASEL CCAR1 TFCP2 PUS3 RBM42 DNAJC8 THOC3 ZC3H11A SF3B5 ZMAT2 ETF1 APOBEC2 FTO PDCD7 CMTR2 RBM11 POLR2I RPS6 PABPC3 RPL5 PSMD1 SRSF6 RBMX HNRNPA2B1 SMG6 SUPV3L1 PRPF4 HNRNPM PCBP4 HNRNPA1 PRDX6 HSPB1 SNRPB2 RPS24 LGALS3 ZC3H14 PSMB6 up
## GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE 0.0011547 0.0154727 0.5207296 2.508733 0 296 ZDHHC4 GET4 BAD TAOK2 RPL13 RPS21 CDK5 MYO1C C16orf70 ZDHHC11B GOLPH3 RPLP0 CIB1 ICMT RPS5 PEX16 TFDP1 ANK3 RPL24 RILPL1 RPS2 ZDHHC11 RPLP1 HPCA RPS3 BRAF HRAS VPS37B RPL36 ZDHHC9 AGK RPL10A RPL39 GGA3 RPSA RPL18A ARFRP1 RPL12 RPL18 EGFR RPL35 RPL29 BLZF1 GRIPAP1 CLIP1 RPL22 RPL13A RPS12 RPS28 ZDHHC7 RPL3 RPLP2 NMT1 RPS15 RAB11B CHMP4B RPL11 PAK1 ZDHHC12 CLSTN1 RPL32 RPS14 RPS11 DMTN FIS1 VPS37C ERBB2 SGTA RPL38 TOMM22 SEC16A TIMM9 ZDHHC1 MICALL1 INPP5K RPS20 YWHAG RPS29 GGA1 RPL37A RPL31 GDI1 E2F1 TIMM13 PMAIP1 SSR2 RPS27 ZFAND2B TP53 RPL27A STX3 SNAP47 BAX RPL19 RPL28 ROMO1 NDUFA13 RPL9 TIMM22 RPL27 CNST RPS8 RPL37 RAB34 GORASP2 CPLX1 RPS7 GOLGA4 RPL34 PPP1R13B KRT18 EXOC4 PARD3 RPS16 AKT2 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 RTP4 UBA52 MIEF2 RPS23 SRP68 RPL14 SRP54 TIMM10 GORASP1 TP73 RAB3GAP2 RPL41 RPL23 RPL4 GRIN3B ARHGAP44 OXA1L SEC61A1 RPL23A GRIP1 RPS13 up
## GO_TRANSLATIONAL_INITIATION 0.0012579 0.0154727 0.5506267 2.496065 0 179 EIF3B YTHDF1 MTOR EIF4G3 YTHDF2 EIF2AK1 EIF6 RPL13 EIF3I RPS21 METTL3 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 EIF2B5 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 EIF3C RPL35 RPL29 HABP4 RPL22 RPL13A RPS12 DHX29 RPS28 MTFMT EIF3D RPL3 RPLP2 RPS15 RPL11 EIF2B3 EIF1AD EIF3CL RPL32 RPS14 RPS11 EIF4G1 RPL38 EIF3G LARP1 PAIP1 RPS20 DHX33 RPS29 RPL37A RPL31 TPR RPS27 RPL27A RPL19 RPS6KB2 RPL28 RPL9 EIF3L RPL27 RPS8 RPL37 KHDRBS1 RPS7 AGO2 RPL34 EIF5B EIF2B4 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A EIF2B2 RPL30 UBA52 RPS23 RPL14 RPL41 EIF2AK2 RPL23 EIF4EBP1 KLHL25 RPL4 RPL23A RPS13 MIF4GD up
fgsea_plot(fgsea_res$res_c6, pathways_title='C6 oncogenic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ----------------------- ---------- ---------- ---------- --------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## MYC_UP.V1_UP 0.0012837 0.0074715 0.5789805 2.579186 0 157 UTP14A TRNAU1AP MRTO4 TMEM201 NIP7 IPO4 DGAT2 NOC4L CDCA7L PES1 PUS7 FARSB PMM2 NOP14 FAM86C1 REPIN1 TRMT1 SLC25A22 NOL6 RPTOR C19orf48 MICU1 RRP9 HS6ST2 DCTPP1 NLE1 UBIAD1 SPATC1L PRR7 MNT QSOX2 NR2C2AP KLF16 LAS1L ECE2 TFB2M B3GNTL1 LRRC61 AMPD2 VPS9D1 MTFP1 EXOSC5 PPRC1 METTL1 PLA2G4A CD320 PUS1 CHCHD10 CCDC124 USE1 SMYD5 DPP7 CHKA ISOC2 GPD1L MPHOSPH10 RPUSD4 WDR83 ESF1 PRMT3 WDR4 SLC29A4 RRP12 C20orf27 DIS3L TOP1MT JPH1 SIX3 TGFBRAP1 ALG3 QTRT1 MON1A C12orf66 ICAM5 AGPAT3 DGKD SCFD2 RRP15 ABCC6P2 TSFM GEMIN5 GP2 CCDC78 TSSC4 DPYSL5 TMEM132B DDX10 SLC25A15 CD3EAP TDRD10 LYPD6 PUS3 C5orf46 TMEFF2 NEFH SORD KLRG2 CALML4 WDR43 GLRX5 up
## CAMP_UP.V1_UP 0.0012579 0.0074715 0.4821780 2.188798 0 181 FBXO42 WDR24 SESN2 RBCK1 GAS5 TRIM2 IPO4 MRPS18A EARS2 TRMT61A RHOT2 CMTR1 PRMT1 LONP1 PYCR2 CEP250 DAP3 ARF1 BLCAP RPL18A AKAP6 NRSN2 MAEA SLC25A5 MIDN AHCYL1 SRPK1 DDX23 RABGGTA AATF RUVBL1 FAHD2A EIF2B3 NDUFV1 KANSL3 GMPPA HSPBP1 HSPA9 CCDC124 SAT2 SMYD5 CHAF1A GPR160 HAX1 P4HB ECSIT PMAIP1 CRABP1 HDLBP TMEM8B CKMT1A DPM2 SIL1 TYMP IFIT2 CS RNF41 XIST TAF1D TMEM9 UPP1 LETMD1 KAT5 ALDOA TFPI2 IFRD1 PLCH1 MAGOH ATP1A1 PA2G4 NME1 SELENBP1 OXA1L SEC61A1 CLPTM1 ILF2 IFITM1 DPAGT1 COX8A ATF4 SLC25A11 TMED9 ZDHHC23 TNIK METTL17 ZNF385A NSUN3 HNRNPU ANKRA2 NDUFS2 COPE AAAS up
## PRC2_EED_UP.V1_DN 0.0012642 0.0074715 0.4366478 1.975912 0 179 MFHAS1 THRAP3 ATP13A2 TBL3 PACSIN3 PWP2 BTBD2 CLPB ABCB9 PHKG2 MVD TSC2 WIZ PRMT7 AP1G2 MAP3K6 LRRC20 DDX31 TRPM4 FZD8 ABCB8 BCKDK ODF2 VAC14 RANGAP1 CDK18 CHAF1B TACC3 DNAJB2 TNS4 MICALL2 SLC35C2 EXOSC2 RNF19A USP20 TRMT2A TAF1C SLC9A3R2 APLP1 XRCC3 PLK1 CLSPN ALG12 TCIRG1 ANKZF1 CA9 AMDHD2 NYNRIN GSDMD POLD1 QTRT1 INCENP HIVEP3 LIPE PAGR1 TNK2 ERCC2 TOP3B SURF2 MISP TUT1 RAD54L SLC26A1 MIA NUP188 GALK1 DBF4B JUP RECQL4 CDCA8 IDH2 STXBP2 LSS SLC12A4 SIPA1 PACS1 BBC3 SYMPK MCM2 up
## RPS14_DN.V1_DN 0.0012642 0.0074715 0.4332220 1.958682 0 172 TBRG4 EPB41 MRTO4 IPO4 ZNHIT2 AGAP1 PES1 MRPS2 SLC29A2 GEMIN4 MACROD1 LGR4 RPUSD2 NLE1 LRRC20 THEM6 TUBGCP4 TUBG1 CDR2 TUBB2A AGFG2 EPCAM ZNF74 RPS28 ELMO3 GPATCH4 TLN2 SRM EIF2B3 PYCR1 EYA3 CD320 CHAC1 TUBB2B RRS1 SRD5A3 PLK1 SH3TC2 MRPL12 ISOC2 STEAP3 GCDH PRMT3 ATAD2 ASNS REPS2 POLD1 INCENP PSAT1 ERCC2 MYO19 TK1 SLC25A21 FZD5 KLHL7 APOBEC3A ALAD ZC2HC1C GSTA4 IL15RA COLEC11 DGCR11 NEFH E2F8 CDC6 RAP1GAP KIF23 DOCK9 BYSL MCM10 TPRA1 MYBL2 TWISTNB NDC1 SHMT1 CAD GATC MKI67 GINS2 DDN PCK1 CDC20 ORC1 PCSK7 SLC29A1 CBS KIF5A MCM5 KIF2C SUV39H2 SPHK1 up
## AKT_UP.V1_UP 0.0012887 0.0074715 0.4331547 1.922856 0 152 GIPC1 PACSIN3 IFIT1 GUSB PLAT GDE1 LRG1 TNFRSF12A DHCR7 CYP51A1 MICU1 HOXB9 TACSTD2 SECTM1 FDFT1 CD55 PDZD11 ADORA2B PREP TPRN PAK1 TRAF4 SNHG11 MYO5B RIPK3 TJP3 TOM1L1 GAK SGSM3 ABCA7 GSDMC COMTD1 KCNK5 SYT17 MAL2 IFIT3 ALDOC MMP15 FBXO6 DHCR24 IFIT2 PON2 FXR2 PTRH1 LDLR PARM1 SH3BGRL2 SUCO CLMN MAN2B2 PTPN14 BPGM PFKP HIC2 CAMKK1 DUSP10 ACOT9 LSS DLG4 TOR3A up
## P53_DN.V1_UP 0.0012531 0.0074715 0.4187763 1.904109 0 182 DHRS3 SUN1 SNHG3 MARK2 TMEM30B PPL EXPH5 RAMP1 TPBG DAAM1 LSR CST6 AUTS2 LRIG1 TACSTD2 SDC4 PTPRH LZTS3 SMAGP EGFR LPCAT4 EPCAM AGR2 IFI27 ADORA2B CTNNBIP1 FHL2 TOX3 ME3 CDKN2A TUBA4A SYNJ2 ASS1 NKX2-1 PTK7 GPSM2 CHKA TJP2 ELF4 PPARD CORO2A MYOF TSPAN8 PTN SPINT2 UQCRH AZGP1 KRT18 AHR ITGA2 KLK10 KRT19 ANXA2P1 LRRC42 MISP KAT5 HDAC9 SOX9 SERPINB5 up
## MTOR_UP.V1_UP 0.0012903 0.0074715 0.4261326 1.891708 0 153 USP18 GSS NTSR1 CCDC86 SC5D TMEM53 IFIT1 SCGB3A2 IFI35 PLAT RCOR2 BST2 TNFRSF12A DHCR7 CYP51A1 MSX2 FDFT1 KRBA1 CCAR2 AP2B1 PCYT2 TIPIN ADORA2B PREP ABCA2 PAFAH2 CAPN12 BDH1 TRMT5 ADRA1B PRKCA GSDMC CYP26A1 COMTD1 PPAN OAS2 FDPS TARS2 HTT ALDOC DHCR24 HIVEP3 IDH3A IFIT2 FAM131A LDLR H6PD COQ4 PSAT1 PCNA ERN1 PTPN14 SERPINB5 up
## PDGF_UP.V1_UP 0.0013123 0.0074715 0.4190135 1.824677 0 133 PSMC6 MPI PPP1R37 EXOSC10 SLC7A5 MORC2 JOSD1 ZBTB18 PSMC3 RNF4 GLOD4 CBX4 EZR LAS1L TAF12 TFIP11 SNRPD3 MADD GPSM2 CHKA ZNF394 TJP2 SNRNP40 URB2 PEX11A GADD45A FKBP2 ATXN2 HDLBP LRPAP1 PFKFB3 NUP160 SNRNP35 ETFB MRPS11 RAB40B HDAC4 CITED1 RAB35 VPS39 ATXN7 UTP3 PAF1 FOSL1 MBTPS1 RNF19B TFPI2 THOC2 up
## CSR_LATE_UP.V1_UP 0.0012887 0.0074715 0.4102177 1.823924 0 156 NOC2L EIF3B POLR3K CDK5 CHEK2 FARSB ASB6 C19orf48 DCTPP1 NUDC TUBG1 PSMC3 ALKBH7 FARSA FEN1 PRMT5 TOMM34 SRM TUBA4A KIF22 LMNB2 IMP4 NKX2-1 YIPF3 MAZ BEX1 CIAPIN1 CLSPN DRAP1 FANCA NUP88 UTP18 CTPS1 MET SLC16A5 ZWINT POLD1 PPP5C KRT18 MCM3 DTYMK GYS1 PSMD2 FOXM1 NETO2 DCBLD1 WSB2 UMPS TSPAN13 PDCL3 CCDC34 LYAR CDCA8 PA2G4 CASP2 KCNC4 TPM2 PREB ILF2 SLC25A11 PAICS SAMD11 EZH2 GMNN CBFB up
## LTE2_UP.V1_DN 0.0012531 0.0074715 0.3989852 1.814122 0 182 ISG15 USP18 NAV2 IFI6 UTP14A PPM1E OAS3 NIP7 MYO10 IFIT1 IFI35 GPER1 HERC6 LGALS3BP BST2 LGR4 ARHGAP12 OASL RRN3 MOCOS IRF7 IFI27 ASCL1 TAF12 FHL2 NCOR2 IFI44L SLC16A7 GTF2I SLC1A1 OAS1 MDK CALCR PTGES PLCB1 ZNF107 GADD45A OAS2 PMAIP1 RHOBTB3 CRABP1 DDX60 ELF4 PARP12 IFIT3 IFI44 PTPRK TFAP2A BTG3 NUP160 SVIL GART DDX58 PSAT1 AMIGO2 RPS6KA3 TFPI2 COL9A3 IFRD1 IFIH1 EIF2AK2 UBE2L6 GRB10 SYTL2 IFITM1 HERC5 PEG10 DLC1 STC2 RFWD3 KAZN FTO PRKAR2B IRF9 TSPO SATB2 TRIM14 up
## E2F3_UP.V1_DN 0.0013038 0.0074715 0.4091675 1.789045 0 137 PRSS33 TBRG4 AXIN1 SNHG3 LIF ZNF3 MARK2 FBXL19 STK40 SNORA28 PLAT MRPL55 LRRC8E NR6A1 ZNF646 SNAPC4 RAB43 ADM2 BDKRB2 NAT9 GPRC5A RNF215 HOXC4 EIF3CL PVT1 SOX1 URB1 MEGF6 CBLC B3GNT3 EHMT1 ETV3 STPG1 DOK7 KRT80 ZFAS1 PPAN ESF1 PMAIP1 PPARD NYNRIN NRL up
## E2F1_UP.V1_UP 0.0012706 0.0074715 0.3942286 1.779953 0 173 SRSF4 UBN1 USP39 GPN2 TAF6 SLC35E1 EIF6 MPG PHF12 PTPRU ZFPM1 UQCC1 GRWD1 DCTPP1 THOP1 VPS37B FEN1 CDR2L CSTF2 RND2 NOLC1 NOP56 RBM15 CHAF1B USP10 RRP1B DDX46 HSPBP1 PITPNM1 MAP3K11 CLN6 DNAJC21 LARP4B TYRO3 SLBP PKP4 CNIH2 SLC9A3R1 ELAVL1 PSME3 AGO2 STIL DNAJC2 GRSF1 BOLA3 NASP MSH3 ARHGAP8 ERCC2 UBE2T PARP1 DDB1 ARHGAP39 TK1 DLX1 TPM2 SHBG TYMS PIGA PACS1 EZH2 INO80E ZSWIM7 POLA2 CHEK1 E2F8 SLC7A1 ADCY6 MCM4 CYBA WDHD1 TINF2 MCM10 MAPK14 RBM22 UPK2 CAD CASP7 MRPL46 KLHL21 up
## PDGF_ERK_DN.V1_UP 0.0013158 0.0074715 0.4055340 1.753119 0 128 ANXA10 AAGAB RALYL MPI PPP1R37 EXOSC10 CHEK2 CMTR1 TSPAN5 RRBP1 LRCH4 NTNG1 CLCN2 ANXA11 PHLDA2 LAS1L CFDP1 TAF12 SOX21 SNRPD3 ZIC4 CLEC2B CCP110 SNRNP40 PSMB10 MID1 SNX19 ATXN2 HDLBP LRPAP1 C17orf75 MVK RPIA ALDH5A1 PAN2 GALNT3 NUP160 MRPS11 CDC14B VPS39 ATXN7 MTHFR ABCC6P2 THOC2 AQP3 up
## RAPA_EARLY_UP.V1_DN 0.0012674 0.0074715 0.3885286 1.748902 0 167 TAF4 NUMA1 OSBPL2 ZNF3 MARK2 GABRB1 SF3A2 STK11 LGALS3BP MICU1 COL9A2 CRY2 GDPD5 HLCS ESRRA SNAPC4 ABTB2 CHKB BRMS1 PRKCE ATG2A BCKDK CBX4 YIPF2 PSMA7 GALNS IFI27 OVOL1 WDTC1 SNTB1 INPP5J KDM4A LMNA PISD SEC16A DPH1 BCAT2 EPHB4 MID1 FARP2 WNK1 XRCC1 CCDC85B MET SLC9A3R1 NFE2L1 TFAP2A GRIN1 SCO2 DUSP14 ITPKC PINK1 CIB2 GPT LHB SPRR1B MTMR3 KDM4B PSMD13 EDDM3A CDH12 EIF4EBP1 GBF1 APBA3 ACTR1B WFS1 MYCN GNRH2 BBC3 up
## CRX_NRL_DN.V1_DN 0.0013441 0.0074715 0.4099622 1.748732 0 115 TRAPPC3 METRN INPPL1 RNF25 WWC1 CLPB TNFRSF12A PRMT1 SDC4 TNPO2 SPINT1 AP2B1 GGT7 ACBD6 SLC25A51 GDPD3 HES5 SLC26A4 GTF2I QSOX1 ENC1 HS3ST1 RREB1 BAX ELOVL7 PAM SALL3 CITED1 NTN4 BSPRY TMEM87A LRRC4 ASPH SLC25A13 PTPN13 ECE1 LSM12 RGL3 ATOH7 FMN1 RAB27B TMEM106B FZD5 GRIK2 up
## AKT_UP_MTOR_DN.V1_UP 0.0012610 0.0074715 0.3875375 1.747374 0 166 GIPC1 PACSIN3 IFIT1 GUSB PLAT MLLT1 SUSD4 GDE1 LRG1 TNFRSF12A DHCR7 MICU1 MVP TACSTD2 ZNF746 DUSP8 TMEM186 HOXB3 CD55 HOXB5 PDZD11 ADORA2B DAGLB TPRN PFDN2 PAK1 ELL SNHG11 MYO5B TJP3 GAK ABCA7 GSDMC KCNK5 SYT17 GGA1 MAL2 ALDOC FBXO6 DHCR24 RNF41 PON2 FXR2 PARM1 SH3BGRL2 SUCO CLMN MAN2B2 RNF19B ZBTB21 MPP2 NOL12 HIC2 BMP8B CAMKK1 CXCL5 DUSP10 UBE2R2 LSS TOR3A FKBP8 MYCN PON1 GPD2 up
## RB_DN.V1_UP 0.0013351 0.0074715 0.4055898 1.741114 0 123 PMS2 STUB1 TMEM54 NME4 MRPL49 DNMT1 LCMT1 SLC35B2 AHCY PLXNB2 TUBG1 TTI1 NXT1 PRKCE SLC2A8 MAPK13 PDXP TIPIN SPICE1 MAN1B1 OVOL2 EI24 CLN6 CCDC88C TNFRSF18 SLBP VPS16 PLEKHA6 C20orf27 PRKAB1 DCXR GANC UCK1 TIMELESS MCM7 IL36RN PCNA UBE2T MANSC1 GRB7 RAD54L ZSCAN22 DSN1 ARTN RPA1 SIVA1 BBC3 POLE2 MSH6 ZBTB8A ACOX3 AAAS NUDT5 POLD4 RRM2 CTC1 ARHGEF40 TNFSF9 TPRA1 up
## CYCLIN_D1_KE_.V1_UP 0.0012723 0.0074715 0.3831423 1.731323 0 178 E2F4 SLC6A3 CENPB AXIN1 MAD1L1 TTLL12 ZIC1 COASY NTN3 PHKG2 PTPN3 LMF2 TSC2 HSF4 CTBP1 THOP1 PTPRH CDR2 ZNF787 PCGF2 CDR2L EPHA2 DNASE1 PFKL FHL2 FOXK2 DAP CDKN2A KIF22 LCN2 PMPCA CHKA TRIO CDS1 STT3A SUPT5H POLR2C PKD1 HOXC5 ASNS MMP15 RASSF7 TFAP2A ADRA2A MAN2A2 POLD1 PPP5C AHR DGKD LTBR EVX1 GPT SCAP KAT5 PLOD1 SNRPC GP2 PKN1 FAM189A2 BRF1 CYP2E1 KCTD2 IFITM1 FZD5 PLK3 RUNX1 PDE4C MED24 BATF EIF5A CEBPD SLC38A3 RGS3 DMWD COX17 SNRPB2 GGT5 PHF20 MALL NPR2 up
## LEF1_UP.V1_DN 0.0012706 0.0074715 0.3821524 1.725429 0 173 USP18 NME3 KIAA0319L OAS3 TMEM53 TFF1 HERC6 RAB25 GDE1 ANK3 TMED3 MVP ANKFY1 TRPM4 BDKRB2 SLC22A18 MOCOS ELF3 PRSS8 AGR2 FOXA1 RBM47 RABL6 CFTR GDPD3 AP1M2 ACSF2 PAK1 KCNV1 TMPRSS3 IL20RA SLC1A1 OAS1 ENTPD3 ENC1 CYP2J2 HCFC1R1 TSPAN8 PRR15L ALDH5A1 SLC6A20 EHF TLR3 TMEM144 CTSH ACSL5 GALNT12 ALCAM MST1L COCH DDX58 PTPN13 MANSC1 TSPAN1 DPP4 ELL3 HAUS4 DAPK1 PLLP CXCL5 SCG5 SELENBP1 RAB27B ATP1B1 FAM83E CPOX MLLT3 TRAF3IP2 SORL1 C4BPB HNF1B FBXL15 RHOBTB2 PDZK1IP1 ATP2A1 up
## GCNP_SHH_UP_LATE.V1_DN 0.0012674 0.0074715 0.3823053 1.720889 0 167 ATAD3A ADCY9 AXIN1 UBE3C ZNHIT2 EIF6 WWC1 NTHL1 ZFYVE19 WLS MIIP MLLT1 WIPI2 PTPRU SNX21 ZDHHC5 LSR EEPD1 ACVR1 PIP5K1A LGALS4 FAHD1 PITPNM1 PAK4 EPB41L4B PUS1 AGTRAP IL4R RMDN3 NCOA7 NUDT1 ACTN4 B3GAT3 DDA1 HTR3A NCOA6 STX3 WNK2 CLCN6 DSCR8 RAB34 SSBP4 ARAF ESRP1 BCL2L2 TCEA2 CSF2RBP1 SH3BGRL2 PLD2 PITX3 GRB7 MED12 UBE2V2 PTPN18 DHODH S100A13 NDUFA10 DLG4 NBEAL2 CDCP1 PPFIA4 COX6A2 GPR3 PEMT TMEM214 MUC3A PDCD7 SLC25A45 IRF9 PDZK1IP1 POLD4 MRPL3 CLRN3 SLC2A1 up
## PDGF_ERK_DN.V1_DN 0.0012920 0.0074715 0.3898293 1.714666 0 141 GIPC1 FADD ARHGEF16 NCAPH2 FBXL18 ISL1 PHLPP1 PPP6R1 DTX2 SNAPC4 MAD2L1BP MNT PPM1A DUSP8 PRCC ZNF500 CDR2L EFNA3 ERF BRPF1 TFIP11 IDUA MAPK3 THAP11 PPRC1 PITPNM1 FAM50B PISD ZNF202 MOGS TBKBP1 DHX34 MFSD5 PPP2R5B PDE4A TBCC SCO2 SLC3A2 BAG5 MON1B CCNF C2CD2L ARF6 KDM2A CIC FAM102A ZNF324 BPGM SMOX HIC2 SULT1A1 KLHL25 MYCN PRSS16 FAM89B MBD3 NEFH DIP2A CEBPB TMEM115 SAC3D1 NOP16 FBXL14 SUOX LRRC6 TRIB1 SLC25A44 HINFP up
## MTOR_UP.N4.V1_UP 0.0012469 0.0074715 0.3745870 1.706979 0 183 GALE USH1C RPAP1 ASPHD1 TBRG4 CCDC86 TRIB3 SPRED2 SLC7A5 CLPB COASY TIMM44 DHCR7 GFPT1 RRP9 CDK16 LHX2 TUBB2A LPCAT4 EBNA1BP2 ACACA DDIT3 EIF2B3 PYCR1 STX4 ASS1 PLS1 YRDC CHAC1 PSPH PLCB1 ISOC2 MAST2 CNIH4 RRP12 NME7 PTPRK ASNS PHGDH SLC3A2 RBM28 PCK2 IDH3A BSPRY SAR1B PAK1IP1 KIF21B ELOVL6 PJA1 LDLR SLC6A9 SLC4A1AP RIMS3 RRP15 SLCO4A1 IFRD1 LIMA1 SLC1A5 BHLHE40 EIF4EBP1 MCPH1 GAS2L1 ETNK1 ULBP1 ARG2 KLHL7 PDXK TRAF3IP2 CASR BATF GALK2 CALML4 SDF2L1 VPS33B CEBPB up
## EGFR_UP.V1_DN 0.0012610 0.0074715 0.3771652 1.700606 0 166 IFI6 NME3 PRPF6 TTC39A GPER1 METTL3 HERC6 BST2 EPS8 MEX3D FAM50A TSPAN5 ARMC9 ANK3 RPP25 PRR7 BDKRB2 MOCOS NET1 IRS1 IFI27 ASCL1 TAF12 NUP205 AGL IFI44L OVOL2 TMPRSS3 BDH1 GTF2I GOLGA8A SLC1A1 CELSR2 MDK CALCR PSPH SIGMAR1 ZNF107 KRIT1 RHOBTB3 DDX60 SH3GLB2 IFI44 TRIM24 PRR15L BTG3 CTSH RUFY1 STIL ANXA9 KIAA1324 up
## NRL_DN.V1_UP 0.0013351 0.0074715 0.3932323 1.688066 0 123 SPEN DHRS3 RNF207 STARD10 RFX2 STK35 SLC29A2 KMT2C PLAGL2 NME4 CNGA1 CNGB1 LAD1 NGDN CDR2 SUPT6H CLDN23 REEP6 RHPN1 TFF3 GRTP1 GPSM2 GADD45A ZC3H3 KCNJ14 NRL GALNT10 IRF6 GNB1 GRIK5 BCL3 NR2E3 DUSP14 KLHL36 PPARA POLR2A TNFAIP2 B4GALT1 LLGL2 BBS9 HIC2 ALPL PROSER2 GRIP1 EML3 ARG2 SAMD11 NLGN2 up
## MEK_UP.V1_DN 0.0012610 0.0074715 0.3712391 1.673885 0 166 ISG15 USP18 IFI6 UTP14A QPRT TTC39A OAS3 GNL2 IFIT1 IFI35 GPER1 METTL3 HERC6 BST2 AUTS2 LRIG1 OASL RALGAPA1 MOCOS IRF7 IFI27 ASCL1 IFT57 AGL IFI44L ASS1 GOLGA8A OAS1 CALCR PSPH ZNF107 OAS2 GDAP1 PRMT3 RHOBTB3 DDX60 IFI44 GOLGA4 ABCA12 ANXA9 F12 ELOVL6 DDX58 KIAA1324 AMIGO2 LSM7 HIRA TFPI2 COL9A3 IFIH1 UBE2L6 DCAF6 IFITM1 DLC1 FTO TCN1 TAF2 PRKAR2B IRF9 CETN3 SATB2 TRIM14 up
## ESC_J1_UP_LATE.V1_DN 0.0012723 0.0074715 0.3670576 1.657366 0 174 POLR3K CRCP BMS1 AMH WWP2 MSANTD2 PUS7 MTG2 MDN1 RPP25 RRP9 NSUN4 CLTB HOOK2 DDX27 TRH RNPC3 PRMT6 ATG2A SULT4A1 KNOP1 PHLDA2 POLE GPATCH4 DDX49 TCEA3 TBCE ARMC6 LMNB2 PASK ANGPTL4 PPP4R1 TUBB2B TSPAN17 HARS2 WDR83 SMARCD3 PIH1D1 MVK RRP12 PPCS PHB BCL3 SLC4A3 ZNF428 ETV4 ICAM1 GYS1 ZFP62 FOXN4 NPHS1 SLC1A5 ENDOG NNAT BHLHE40 DHODH MSRB2 CAMKK1 GNG3 up
## RB_P130_DN.V1_UP 0.0013333 0.0074715 0.3848091 1.644635 0 114 GC POLD2 ZBTB17 GFER ICA1 FAM220A NSMCE1 DCTPP1 SIM2 SNRPB ENKD1 RUVBL2 TRAF4 ELOF1 VSIG2 KIF22 RIPK3 OXLD1 LSM4 SGSM3 GLIS2 EXOSC2 GRTP1 USP13 CRB3 RAD51D QTRT1 PCSK5 C12orf10 AQP5 EFTUD2 HINT1 ZNF428 CHCHD6 RGL3 TK1 KAZN CUEDC2 MBD3 POLR2I ZBTB12 SDF2L1 ATP2A1 RSPH9 UBE2C STMN3 CYBA PPP1R15B CASP7 TEAD1 TRAF2 TINAG ORC1 RGS16 SLC29A1 ART1 BIRC5 TWIST2 SLC22A3 CACNG4 AURKA FADS2 ANAPC5 PARS2 up
## E2F3_UP.V1_UP 0.0012626 0.0074715 0.3619320 1.635249 0 171 MFHAS1 SNRNP25 CMPK2 CABLES2 TMEM201 NUDT22 TPPP LRRC45 MBOAT1 SBK1 MNX1 TSPAN5 MANEAL EMC9 NGEF FEN1 RTN4RL1 POLE DDAH1 PDXP KLF16 EEF1A2 TLCD1 ANKRD18A BRI3BP ZDHHC12 PDIA2 TP53I13 FBXL16 CCP110 GPR160 CYP26A1 FGF9 FANCA ATAD2 PXMP2 ANTXRL MMP15 JPH1 DHRS13 NPAS1 SAMD1 ZIC2 FAXC SLC4A3 ZNF703 HEY1 PIN1 TLE2 PCNA CDC20B RECQL4 TMEM106C PEG10 CHST2 FAM222A ZDHHC23 POLE2 RTN4R SAMD11 SLC6A2 LIN7B RHOBTB2 MAP6D1 ATRNL1 GAD1 SAC3D1 SYNGR3 NAT8L UGT8 SLC27A2 SH3BGR RASGRP1 MSRB1 KCNS3 HRK KISS1R PYGO1 TSHZ1 up
## RB_P107_DN.V1_DN 0.0013245 0.0074715 0.3765678 1.606555 0 113 BSDC1 RNF25 AP3D1 COASY PMM2 NSUN2 GALNT11 BLCAP ELOVL1 EIF3C TPRG1L LAS1L PLEKHA7 PINX1 BDH1 PDCD6 CHAC1 SIGMAR1 MOGS TXN2 MYO1D SRI NME7 NFE2L1 LACTB2 COQ9 AKAP9 BIN3 SAR1B ELOVL6 SYTL1 PAFAH1B3 SPG11 ACADVL ANXA4 NIPSNAP1 AIMP1 TXNRD3 NRBP1 ERCC3 APTX PLK3 STAT6 GSTA4 DGAT1 ARPC1B up
## ERBB2_UP.V1_UP 0.0012706 0.0074715 0.3554467 1.604701 0 175 PCDH8 SLC12A2 METRN PACSIN3 VWA1 MPI CAPN2 GDF15 PTPRU NME4 FGF13 MVD DNAJC4 SCAMP4 LRP5 BMPR1B THEM6 MSX2 HOXB7 SLC2A10 DBNDD2 GDPD3 ACHE ALDH4A1 BCL6 ZNF467 ANGPTL4 APOBEC3B SLC9A3R2 APLP1 MYO1D CAST TTC9 SH3GLB2 PTOV1 CADPS2 ALDOC ABCC3 LMO3 PRPS1 GALNT12 BCL3 TCEA2 GABBR2 HEY1 PARM1 ASPH VTCN1 CLMN MUC1 TSPAN1 VEGFB SOX9 PLEKHB1 AQP3 GBF1 KIAA0513 SPTBN2 MAPRE3 LOXL1 GAMT TNFRSF21 PACS1 SPAG4 P4HA2 up
fgsea_plot(fgsea_res$res_c7, pathways_title='C7 immunologic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ---------------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0012225 0.0087574 0.6274850 2.840717 0 187 NOC2L AURKAIP1 UBN1 TBL3 E4F1 AMBRA1 SRRM1 TAF4 POLD2 ADRM1 ZBTB17 OSBPL2 TSR3 DNAJC17 NADSYN1 SLC7A5 CDC37 SLC2A4RG LRRC41 SF3A2 MRPS2 PTBP1 ZNF512B TMEM259 SIGIRR PEF1 SLC25A22 ABCF3 THOC6 XAB2 VPS51 PPP6R2 HRAS SART1 TSTA3 AAMP RPL36 COPS7B WDR18 PRCC ANAPC2 BRMS1 AP5Z1 UBE2M SSRP1 LPCAT4 TRIM28 STK25 NAA60 ATP13A1 CFDP1 C9orf16 RPLP2 PRPF19 DCAF15 GATAD2A GADD45GIP1 RPL11 PFDN2 NONO FOXK2 TACC3 U2AF2 VPS9D1 TAF10 MFSD10 HMG20B EXOC7 HSPA9 POLR2E PDAP1 EEF1D NELFB MARCKSL1 CDCA4 FUS RALY CCS TAF1C RRS1 EDF1 MRPL12 PSMB10 DRAP1 THAP7 GCDH SMARCD2 RPS27 DAZAP1 CCDC85B TP53 SH3GLB2 PDIA4 RPL37 QTRT1 IRF3 SPINT2 DGKZ TRAPPC2 RALGDS COPG1 STARD3 PAF1 UBE2S NFKBIB PIN1 SAFB2 FBXO41 ABHD17A SNRNP70 BANF1 ATP1A1 TNFRSF14 NDUFC1 LSM12 IMPDH2 APBA3 TSSC4 CLPTM1 SIPA1 SAFB SRSF9 TMED9 up
## GSE6269_FLU_VS_E_COLI_INF_PBMC_UP 0.0012563 0.0087574 0.6005271 2.649589 0 153 ISG15 USP18 GLYR1 RNF40 IFI6 SLC4A2 C2CD3 KCTD13 GSE1 RSAD2 MARK2 MX1 OAS3 CAPN15 IFI35 AP3D1 MX2 NFATC2IP XAF1 HERC6 GTPBP2 POLM LGALS3BP CMTR1 AGRN PKM SZRD1 OGDH DNAJC4 OASL TRABD CHST12 PI4KB ARPC1A IRF7 SUPT6H ADAR ACIN1 HECTD3 ATP13A1 SZT2 DCAF15 USP10 CXXC1 SHC1 IFI44L EIF4G1 SREBF2 OAS1 GAK LARP1 SMG7 C16orf58 SPATS2L MOGS ACTN4 OAS2 STRN4 DDX60 NCOA6 GOLGA2 PARP12 IFI44 BPTF DCTN1 NPIPA1 IRF3 PSME3 VPS39 UBA1 TYK2 TRIM21 ZSWIM8 MLEC GPATCH8 ARHGDIA MYO9B SART3 DNM2 NRBP1 EIF2AK2 ATP2A2 up
## GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_DN 0.0012255 0.0087574 0.5736510 2.588080 0 184 EIF3B TBL3 CTU2 MTOR NADK LYPLA2 CLUH MNAT1 SNHG3 ZNF768 FAF1 GNL2 CDC34 EIF3I LETM1 ZMYND19 ALG8 TRMT61A CYP51A1 AHCY TSTA3 CLNS1A FDFT1 MRPS26 BCKDK PDZD11 ACACA LAS1L GRPEL1 GPATCH4 NMT1 SRM NAT10 NDUFV1 TCERG1 NDUFB7 MRPL37 PPRC1 EIF4G1 LZTR1 EIF3G SMYD5 SLC25A10 CNIH4 NTMT1 HDLBP BOP1 PTOV1 CCT7 MRPL23 UQCR10 BZW2 FBXO6 PHF23 RPA3 HIVEP3 IDH3A BSPRY PABPC4 HMBS EIF5B PPIA HINT1 NHP2 PIN1 PCNA GCSH ITFG1 CERS6 UQCRQ MAP2K3 ACADS LRP11 SPRYD4 TMEM51 DDB1 RAD23B ATP2A2 ZMYM1 NME1 LSM12 DUT POLR1D LSS MRPL36 UROD ADI1 NFS1 PGLS CD3EAP ALAD C1orf50 GATAD1 SQLE EML2 MBD3 POLA2 ACY1 FBXL15 GFOD2 NUDT5 SUPV3L1 PRDX6 CLPP up
## GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0012300 0.0087574 0.5732457 2.584775 0 181 AURKAIP1 SRRM1 RNPS1 LRRC47 RBCK1 ADRM1 GID8 VPS4A NUTF2 CAPN15 TSR3 NADSYN1 CDC37 SF3A2 PTBP1 ZNF512B MRPS15 APRT THOC6 ADNP2 XAB2 MVP MEAF6 PPP1R14B CHCHD3 VPS51 HRAS AHCY DEAF1 SART1 COPS7B WDR18 PRCC MAP2K2 AP5Z1 SSRP1 LPCAT4 CBX4 STK25 NAA60 CFDP1 RNF126 C9orf16 DDX49 RPLP2 IDUA GATAD2A PFDN2 GTF2F1 NONO FOXK2 U2AF2 TAF10 MFSD10 HMG20B ILVBL HSPA9 POLR2E PDAP1 NSMF MARCKSL1 CDCA4 RALY HNRNPUL1 ECSIT EDF1 MRPL12 PSMB10 DRAP1 SMARCD2 BTF3 NDUFS8 DAZAP1 ELF4 CCDC85B TP53 SH3GLB2 PDIA4 SEC61G BECN1 RPL37 MYH9 DGKZ TRAPPC2 C12orf10 COPG1 STARD3 UBE2S SAFB2 BCL7C FBXO41 RNF19B SUMO3 CORO1B TNFRSF14 NDUFC1 RDH14 LSM12 PKN1 R3HCC1 PABPN1 SAFB SFPQ SRSF9 TMED9 up
## GSE16385_MONOCYTE_VS_12H_IL4_TREATED_MACROPHAGE_DN 0.0012300 0.0087574 0.5724800 2.582788 0 183 GLYR1 TBX6 UBE4B ZNF777 GSE1 ZBTB48 UCKL1 PPP1R37 FASTK TUFM MIIP AP3D1 ABCB9 ATXN2L TMEM259 ZNF384 CENPT RNF31 ARID1A LMF2 MEX3D AUP1 ANKRD54 NIPAL3 PPP1R12C RPS6KA4 SNAPC4 MAPK8IP3 PHRF1 TRABD RNPEP TBC1D9B POLRMT CPSF7 CLCN7 RHBDL1 TRIM11 TSC22D4 SH2B1 NEIL1 TOMM34 AP2B1 LRP10 PCYT2 FHOD1 GNB2 TFIP11 DNAL4 VAPB KANSL3 EYA3 HMG20B RFX1 HDAC7 STRIP1 CIZ1 STX4 GUCD1 NELFB MAP3K11 MRPS35 ABCA7 CHD4 THBS3 NCLN STRN4 CPT2 XRCC1 ZFAND2B RPS6KB2 UBE2Q1 CHRNB1 MLLT6 BFAR TESK1 WHAMM NPM3 LIPE DLST RAB35 DENND4B FAM193B KLHL36 LRSAM1 JOSD2 PELO UTP3 SLC5A6 ADIPOR1 FGF8 RNF19B SNRNP70 ANKS1A NUP188 DDB1 CCDC97 MAP4K2 AKT1S1 KAZALD1 PTCD1 PRRC1 OCEL1 RALGPS1 PITPNM2 CTSA PPP2R3A DGAT1 LASP1 up
## GSE41867_DAY6_VS_DAY8_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN 0.0012255 0.0087574 0.5677575 2.564510 0 185 MFHAS1 NOC2L NOB1 RPAP1 SRRM1 LYPLA2 UBE2I EIF6 NUTF2 FAM118B AIMP2 CTH UBAP2 MTG2 HAGH MDN1 LIPT2 WDR73 NUDC TRMU DUS1L NLE1 MTRR SLC35B1 AHCY TMEM177 SUPT3H SNHG7 MRPS26 ZNF213 MRPL17 GPS1 BLOC1S4 SRPK1 UBOX5 SLC25A39 GRPEL1 TRMT112 DDX49 USP10 JMJD4 RCE1 SNRPD3 TADA2A NSFL1C POP7 EXOSC5 RAD23A PPRC1 POLR2E TOMM22 YWHAG TIMM8B DDX39A PHF5A NCOA5 SPATA5L1 CCT5 MRPL52 COPS6 BZW2 C19orf53 TIMM22 TRIM44 NDUFA4 PPIE CDK4 DNAJC2 MCM3 EEFSEC PAK1IP1 TIMELESS ELOVL6 AEN UTP3 ACOT7 NDUFB9 LSM7 SRP54 PSMD13 NUP188 DYNLRB1 CLDN7 IFRD1 SPRYD4 ACTR10 CHAMP1 NDUFS7 DPH6 MSRB2 DNPH1 NME1 SPAG7 TBC1D10A TMEM209 HNRNPLL DDX10 POP1 PAICS CD3EAP MCM2 C1orf50 SF3B5 FTO AAAS SLC25A38 HNRNPM COPS7A MED29 BTBD19 HSPA5 up
## GSE45837_WT_VS_GFI1_KO_PDC_DN 0.0012346 0.0087574 0.5573586 2.508930 0 180 SNRNP25 NUMA1 MRPS34 RBCK1 CD2BP2 MPI UCKL1 MPG NTHL1 FASTK COG4 EIF3I ECI1 TRADD DECR2 BST2 PRMT1 AUP1 LCMT1 AHCY AAMP DAP3 EPS8L2 ANXA11 ZNF32 RFXANK EBNA1BP2 NDUFS6 AP2B1 HDHD3 C7orf26 DDX49 PLEKHJ1 CLASRP TCF20 PITPNM1 TRAPPC2L FUS TRMT5 NUDT1 STOML2 MPDU1 ECSIT EDF1 NENF DRAP1 DPM3 MZT2B IGBP1 POLR2F EEF2 CCT7 MRPL23 ENSA UQCR10 COPS6 PSMD4 SNRNP35 ETFB MZT2A MRPS11 NPM3 UQCRH RPS7 BANP RALGDS SNRPD2 AEN ZNF428 DFFB PIN1 SRPK2 BCS1L LMAN2 SLC35C1 UQCRQ LSM7 HIVEP2 PSMD13 SAE1 NIPSNAP1 DYNLRB1 GNA12 NDUFS7 YARS2 PFKP DNPH1 NME1 GRHPR PSMC5 CLPTM1 R3HCC1 HNRNPF TOR3A COX8A NFATC1 NDUFA2 OCEL1 ADSL ARPC1B COX6B1 POLR2I DDT ARF5 HSPB1 PSMB6 LAMTOR2 SNRPF XRCC6 UQCR11 SUN2 CYB561D2 DALRD3 SHMT2 COPZ1 TBCA MRPS16 up
## GSE33162_HDAC3_KO_VS_HDAC3_KO_MACROPHAGE_UP 0.0012346 0.0087574 0.5558786 2.502268 0 180 USP18 EPHA5 B3GALT5 TBX6 NME3 PRPF6 AXIN1 PWP2 MARK2 OAS3 STUB1 IFI35 ZNF764 TPBG BCL9L AIMP2 ANKS3 GTPBP1 LGALS3BP CMTR1 SRRT BST2 AGRN REG4 LONP1 PPP1R14B MAPK8IP1 TRAFD1 HOOK2 PSMC3 RAB40C PSMG4 TMEM186 BNIP1 IQCC SCYL1 PMEPA1 TOMM34 CLIP1 SUPT6H CIAO1 PARP14 TFIP11 PLA2G12B ACHE TRAF4 ZDHHC12 POLR2E PSMB5 ASS1 MEPCE LMNA IL4R OAS1 SGSM3 FBXW9 ZMIZ2 PTGES SIGMAR1 MOGS ATG4D MCM3AP OLIG1 TXNDC11 DDX60 RREB1 PARP12 PTOV1 HTT IFIT3 ERBB3 CAMSAP1 NUBP1 KEAP1 CITED1 ZNF574 TEX13B CIC AEN STARD3 PARP9 SLC22A5 RTP4 CYB5R1 RRP15 ELAC2 BUD31 TNFAIP2 ENDOG up
## GSE45365_WT_VS_IFNAR_KO_CD11B_DC_MCMV_INFECTION_UP 0.0012407 0.0087574 0.5595007 2.498500 0 168 GIPC1 EIF3B CABIN1 RPAP1 SRRM1 AMH YDJC NTHL1 CAPN15 MYBBP1A LETM1 NOP2 BCL9L RRNAD1 UQCC1 SNX8 KRI1 RPTOR WIZ ZNF786 LMF1 RRP9 NSUN4 TRMU MAP3K6 ESRRA CACTIN TMEM150A TNPO2 CLCN7 DISP1 VAC14 NAT9 UBTF EZR PRPF8 PELP1 HECTD3 ALKBH4 IDUA TCEA3 ZBTB7A RCE1 TSR1 RRP7A PINX1 CLPX POLG PRR12 RCN3 TAF1C CHD4 CCDC61 PPIL2 DPP9 TTC9 ALG12 BET1L EXO5 HHAT LTK NF2 NEURL4 ZBTB40 ZNF79 RIN1 CCDC142 GLO1 TCOF1 ZNF628 RNF26 AZGP1 DUSP14 KLHL36 PPP1R13B MEF2D CIC PGAP3 ANXA2P1 MYEF2 SLC35C1 TMEM129 SURF2 MBTPS1 IVD up
## GSE32034_LY6C_HIGH_VS_LOW_MONOCYTE_DN 0.0012063 0.0087574 0.5493633 2.494976 0 190 USP18 CDK11B PGP RNPS1 CMPK2 PRPF6 AXIN1 STUB1 CAPN15 FAM207A IFI35 ZNF764 KIF1B AVL9 HOXA11 MIB2 LGALS3BP BST2 AGRN RBMX2 COL9A2 RRBP1 NSUN4 CRY2 LONP1 XPO6 DUS1L SART1 CHKB RRN3 RAB40C RELA DAP3 NXT1 PPP1R8 OLFM3 NDUFS6 RANBP10 LAS1L OSBP EIF3D ALKBH4 FBXO22 PARP14 ATP6V0D1 TRAF4 RPP25L RNF114 POP7 GRAMD1A PITPNM1 SFSWAP CELSR1 TXNL4A OAS1 LARP1 CTDP1 ZNF394 NRG3 TNFRSF18 MPDU1 ENC1 PPAN HARS2 VPS16 DDX60 HEATR1 PARP12 PTOV1 IFIT3 RRP12 TDRP MARVELD2 SEC61G POLR1A CTDSP2 IFIT2 HAUS8 LCMT2 XDH SPRTN DCAF11 GTF3C4 GOLGA5 PARP9 PITHD1 RTP4 ULK1 ELAC2 UBAP1 MAF1 SLFN13 up
## GSE15624_CTRL_VS_6H_HALOFUGINONE_TREATED_CD4_TCELL_DN 0.0012484 0.0087574 0.5608153 2.479769 0 155 DNAJA3 TRAPPC3 TMEM238 NADK PWP2 LRWD1 TAF6 IPO4 DGAT2 LRP8 CDC37 MYBBP1A PHLDA3 RPP25 DUS1L PSMD11 FDFT1 ERI1 PGAP2 BCKDK CCDC127 PPM1G UBAP2L C3orf33 XXYLT1 SNRPD3 PSME2 CELF1 NDUFS3 HSPBP1 PPRC1 IMP4 EEF1D TRAP1 TUBG2 ANGPTL4 CHAC1 RMDN3 GAN IMP3 PLEKHA8 MPDU1 ECSIT SLBP COMTD1 SLC26A6 DPP9 SEC23B C19orf67 C19orf57 HEATR1 BOP1 HIBADH CHID1 CPSF4 SF3A1 SPRED1 KLHL26 FIGNL1 KEAP1 PCK2 TRAPPC2 EFTUD2 MRPL21 SND1 MSANTD4 TRIM21 BCS1L GYS1 TMEM129 RRP15 FBXW11 AIMP1 MRPS12 ECE1 SPRYD4 PA2G4 SPAG7 RPN2 SPATA24 SLC12A4 CCDC6 GLRX3 PDXK HEATR3 FARP1 COX6B1 IMMP2L MBD3 EIF5A SWI5 up
## GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY6_EFFECTOR_CD8_TCELL_DN 0.0012151 0.0087574 0.5404556 2.451338 0 188 MFHAS1 DNAJC11 DHDDS TELO2 RHBDF1 RPUSD1 CYB5B FAF1 YDJC RCC1 OAS3 LRP8 IFI35 PES1 MLLT1 MRPS2 RHOT2 MTG2 PEX16 FGF13 ITPA RBMX2 MVP AP1G2 PSMD11 DHX37 LCMT1 RANBP1 STIP1 NXT1 FEN1 YKT6 BCKDK FIBP ADAR NUP205 PGAM5 RCE1 TADA2A RAD23A POLR2E LARP1 GTPBP4 DOT1L PMPCA AAR2 PPAN HSP90AB1 POLR2C TMEM183A NDUFS4 UPF1 MRPL52 CCT3 UQCC2 TRIM44 PPIE GEMIN8 ALG3 QTRT1 CNOT11 POLE4 MRPS11 ZNF823 TCOF1 HMBS EEFSEC PPIA POLR2H PCNA CFLAR CARM1 LSM7 TMEM216 TTYH3 WDR5 NUP188 IFRD1 TXNRD3 NUP85 NOL12 MAGOH YARS2 CCT2 IMPDH2 ECHS1 TARBP2 LLGL1 NSUN5 WDR70 ZCCHC17 TOR3A up
## GSE43863_NAIVE_VS_MEMORY_LY6C_INT_CXCR5POS_CD4_TCELL_D150_LCMV_DN 0.0012210 0.0087574 0.5413755 2.449741 0 186 NOP9 GIPC1 TMEM248 TBL3 UBE2J2 MLST8 MTOR TBRG4 WRAP73 KCTD13 C1orf122 YDJC UBE3C ECI1 CHERP FLVCR1 SLC41A1 TRMT61A USP54 APRT DPP3 AGRN PSMD3 THOC6 AK2 TSPAN5 KPNA6 WDR73 NUDC DUS1L NDUFAB1 THOP1 PTGES2 DDX31 TMEM150A C1orf53 GGA3 TXNDC17 GIT1 ELOVL1 LUC7L ZNF213 PNPT1 CLIP1 SUPT6H LAS1L ACIN1 REEP6 RABL6 MTFMT MAP1S SRM CCNB1IP1 EIF2B3 NAT10 TADA2A MTFP1 PDAP1 ZNF771 GTPBP4 SMYD5 TRMT6 WDR83 NTMT1 WDR4 TIMM13 TMEM183A BAX MRPS7 AACS MFSD5 TMEFF1 TOP1MT RPS6KA2 TRIM44 CLCN6 TYSND1 WDR3 NUBP1 TESK1 BOLA3 SND1 NHLRC1 HSPA14 NEO1 SCYL3 MRPL27 ELAC2 MAGOH MYO19 CHAMP1 DNPH1 LSM12 DUSP10 SLC23A3 TMEM209 MRPL34 PTPMT1 TMEM41A POP1 CD3EAP PDXK CSTF1 C1orf50 NFKBIZ ETF1 TMTC2 TAF1A RBPMS2 WDR43 SLC7A1 PMPCB up
## GSE360_L_DONOVANI_VS_T_GONDII_MAC_DN 0.0012151 0.0087574 0.5381540 2.440899 0 188 MUC6 DNAJC11 ACD FADD TELO2 SMURF1 POLD2 ADRM1 INPP5B MX1 RCC1 TUFM CHERP KIF1B TIMM44 AIMP2 MGRN1 HAGH NME4 PHLPP1 PIEZO1 RUSC1 HRAS MEN1 CDH1 FEN1 HGS SF1 IRF7 TOMM34 EZR FAM13A C9orf16 ILF3 AATF CPNE1 NONO GNA11 SCGN AMPD2 TCERG1 NDUFS3 SGTA TRAP1 GAK RALY PLCB1 LPAR2 MRPL12 ST3GAL5 PRMT3 PMAIP1 ATXN2 FDPS TFAP4 CCT7 NIT1 MRPL23 ZWINT NFYC ALG3 RIN1 TYMP SPINT2 SNRPA MCCC2 PABPC4 SNRPD2 CH25H NHP2 POLR2H FLII GNA15 SCAP MAPKAPK3 AMHR2 TCF3 ACADS PFKP HPCAL1 SLC37A4 GBF1 TARBP2 GNB5 TLE1 EEF1B2 FKBP9 SRRD FAM3A TYMS SAFB CPOX SIVA1 NCK2 PPFIA4 MCM2 SEL1L3 PRDX2 IL15RA EZH2 ANK1 DGAT1 POLR2I LCOR AFG3L2 up
## GSE21927_BALBC_VS_C57BL6_MONOCYTE_TUMOR_UP 0.0012346 0.0087574 0.5387613 2.425215 0 180 ISG15 USP18 AURKAIP1 PSMC6 RNPS1 HMGA1 MNAT1 TRIB3 MX1 LY6E OAS3 DDRGK1 MRPS18A CLPB PAXIP1 MRPS2 PMM2 ERI3 UBAP2 PSMD3 DNPEP TRIT1 ESRRA PML RUSC1 TRAFD1 PDHA1 TARDBP BNIP1 BLVRA PGAP2 STAMBP ERAL1 NDUFS6 IFI27 PPM1G C1orf109 NIT2 RAC1 STX18 MED8 PRPF19 GADD45GIP1 EHD4 USP10 NAT10 TSR1 MRPL11 PSME2 RAD23A METTL1 POLR2E LSM4 PMPCA MRPS33 CBX6 PPAN DRAP1 NCLN TIMM8B CCDC85B CYC1 MRPL23 MRPL52 ALG3 MIS18A GOT2 UQCRH PSME3 DNAAF2 PFAS CSNK2A1 TRIM21 UTP3 NHP2 ENOPH1 UBE2L3 TACO1 MAPKAPK3 MRPS12 MAGOH DHODH MRPS27 CISD1 UBE2L6 up
## GSE369_SOCS3_KO_VS_WT_LIVER_UP 0.0012255 0.0087574 0.5365939 2.420893 0 184 TMEM248 NOB1 TTLL4 CCDC86 PWP2 CYB5B GFER GUK1 SLC7A6 AKAP1 EIF6 NUTF2 EIF3I FLVCR1 KCTD5 NOP2 FOXRED1 NARS2 PSMG3 MRPS15 WDR55 NXN LGR4 TMED3 RPP25 RPUSD2 RSAD1 PIEZO1 DDX31 SDHB RNPEP STIP1 WDR18 C1orf198 PPP1R8 NR2C2AP ACACA GRPEL1 SUCLG1 ATP13A1 AATF ST7 RUVBL2 TFB2M MRPL11 TADA2A DOHH TXNL4A PDSS2 LARP1 MALSU1 RRS1 DHX33 COMTD1 SMYD2 HSP90AB1 UTP18 CCDC85B FDPS DYNLL2 XPOT CORO2A TFAP4 RRP12 COPS6 CDK5RAP3 CRELD2 FBXO31 MLLT6 QTRT1 CASC4 CS HMBS MRPL21 ELOVL6 LSM7 C1QBP CHMP2A IFRD1 NUP85 CHAMP1 APEX1 FAM185A TEX264 TSEN2 TMEM160 ZDHHC23 CD3EAP TMED1 MRPS5 PRELID2 PUS3 ETF1 PNPO up
## GSE16451_IMMATURE_VS_MATURE_NEURON_CELL_LINE_WEST_EQUINE_ENC_VIRUS_DN 0.0012300 0.0087574 0.5334510 2.406705 0 183 DNAJA3 MFN2 TBRG4 POLR1C CCDC86 TXLNA PWP2 IPO4 MRPS18A LRP8 CLPB CDK5 LIG3 COASY PLAGL2 TSPAN5 NSUN2 ADNP2 C19orf48 GFPT1 CCDC137 WDR73 THOP1 CISD3 MTX1 ARPC1A SSRP1 ZNF239 DDX56 SLC25A39 LAS1L TLCD1 MED8 SRM EYA3 XPR1 HSPBP1 LMNB2 TOMM40 TOMM22 TRAP1 CLN6 HIRIP3 SLC39A3 CHAC1 PSMA3 DDX54 RMDN3 RRS1 TNFRSF18 URB2 POLR3B PCBD1 ACAD9 C1orf216 VPS25 CCT5 CAMTA2 PHGDH QTRT1 SPINT2 IMPDH1 HIVEP3 CHCHD4 FANCE PFAS SND1 HOMER1 BCS1L LAG3 EIF2B2 TACO1 ITFG1 MAPKAPK3 FAM136A RBM19 TIMM10 RAB27A NETO2 SLC1A5 PCCB LYAR ARV1 DPH6 CISD1 SERPINH1 ALKBH2 PITPNA up
## GSE45365_WT_VS_IFNAR_KO_CD11B_DC_UP 0.0012376 0.0087574 0.5355204 2.395254 0 169 MFHAS1 DHRS3 GIPC1 EIF3B CABIN1 SCMH1 CLUH YDJC ANO9 LETM1 POMGNT1 NOP2 BCL9L NOP14 SBK1 CMTR1 MACROD1 CST6 KRI1 DDX51 ANK3 LMF1 TMEM161A TRMU CACTIN ZNF827 TNFRSF25 HPS4 TMEM150A L3MBTL2 IL23A DISP1 NAT9 LCAT CAMK1D PCYT2 UBTF AARS2 RPS12 PELP1 SKI SOX12 TCF20 PINX1 ANKEF1 CLPX RNF220 SMYD5 PRR12 CERS4 ATXN7L2 PPIL2 MARS2 LIME1 ALG12 STYK1 LTK NOSIP ZNF444 TYSND1 ALG3 MPV17L2 GLO1 TCOF1 PSEN2 PPP1R13B MEF2D ANXA2P1 TTC39B FAM102A SURF2 KLHDC4 UTP20 VEGFB C12orf65 TUT1 NIPSNAP1 MAP3K14 RPL39L SLC25A4 CDIP1 C5orf17 EIF4EBP1 MSTO1 ALKBH5 PEG10 SNPH TRUB2 KLHL13 CRTC1 KLF3 MAMDC4 CLUHP3 TRIM3 JAKMIP1 ACY1 up
## GSE40274_CTRL_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN 0.0012500 0.0087574 0.5414396 2.391505 0 148 PIK3C2G PUSL1 TBRG4 POLR1C SESN2 URGCP GUK1 IPO4 FAM207A ZMYND19 FOXO6 GNG4 PEX14 RSAD1 PIEZO1 THOP1 OASL CHPF SLC35B2 C7orf50 SUPT3H POMC NOL9 GIT1 PICK1 PPP1R16A OVOL1 PRR15 SLC25A39 REM2 CCNO SRM CRLS1 ARL14 PFDN2 ECE2 GTF2F1 MRPL11 SIX4 HOOK1 TOMM22 MCRS1 SYTL5 PSPH POLR1B CCDC9 TMEM183A SMARCB1 FOXRED2 AACS DHCR24 PIP5K1C SCIN DNAJC2 GOLGA5 SNRPE HOMER1 RTP4 SLC5A6 SLC52A1 KLHDC4 TMEM200B TOR1AIP2 VEGFB NETO2 CCT6A AIMP1 UBE2U RAB6B MYO19 RPN2 IMPDH2 NDUFC2 GEMIN6 up
## GSE21927_SPLEEN_C57BL6_VS_EL4_TUMOR_BALBC_MONOCYTES_DN 0.0012300 0.0087574 0.5285326 2.383163 0 181 NOC2L EIF3B GSPT1 HMGA1 CLUH POLD2 MNAT1 UTP14A TTLL12 RNF25 GNL2 MRPS18A SLC7A5 CLPB DPH2 ALG8 MRPS2 PMM2 DPP3 NUDC TUBG1 NXT1 RPSA BLVRA DDX56 PSMA7 CLTA PPM1G C1orf109 GRPEL1 RAC1 STX18 PARP2 DDX49 AATF PRPF19 GADD45GIP1 NAT10 PSME2 HSPA9 POLR2E PDAP1 LSM4 CLPX NABP2 GTPBP4 DCPS PMPCA STOML2 SNRNP40 URB2 SLBP NUP88 TIMM8B UTP18 DEF8 PMAIP1 CCDC85B ATAD2 PDIA4 RTCB MRPL52 CRELD2 WDR77 PHGDH ALG3 MYL6B ETFB UQCRH PSME3 DNAAF2 DNAJC2 GRSF1 CSNK2A1 NASP SNRPE NHP2 UBE2S MCM7 POLR2H PSAT1 UBE2L3 MAPKAPK3 UQCRQ ALDOA MORF4L2 NUP188 BUD31 MRPS12 up
## GSE21380_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_DN 0.0012300 0.0087574 0.5277584 2.379672 0 181 GLYR1 TELO2 TMEM150C FBXO34 AMH C1orf122 PPP1R35 EIF2AK1 LRP8 C1orf159 NTN3 ERI3 FAM160B2 TSPAN15 SLC29A2 PLAGL2 SLC25A22 ZBTB45 REG4 WIZ NLE1 ESRRA THOP1 ALG1 TNFRSF25 AGAP3 PRDX5 UBE2M YKT6 SETD1B GNB2 NAA40 RPLP2 PLEKHJ1 CDK10 FOXK2 CHCHD2 EIF4G1 CNFN LDB1 NKX2-1 R3HDM4 C16orf58 NINL TRAPPC2L MRPL4 PLCB1 SIGMAR1 CIAPIN1 TXN2 MPDU1 CDC42BPG PLK1 NCLN PYGO2 FKBP2 FAM120A TXNDC11 CCDC85B C16orf72 RPS6KB2 TFAP4 NDUFS5 C19orf53 FBXO31 TOMM7 DGKQ NT5C ARAF ICAM5 UNC13C AKT2 RPS26 SRPRB LMAN2 SLC5A6 RNF19B TMX1 RC3H1 SARS2 CUBN DCBLD1 NDUFC1 UBXN1 TMEM101 FOXD4L1 AKT1S1 FBXW5 ATP6V0A1 TMED9 TAB1 NDUFAF2 SAG SMTNL1 ZMAT2 G6PC3 CHRNG NOL10 LCOR ATG9B SLC7A1 ARF5 up
## GSE6269_FLU_VS_STREP_PNEUMO_INF_PBMC_UP 0.0012469 0.0087574 0.5326618 2.370337 0 163 ISG15 USP18 GLYR1 IFI6 C2CD3 RSAD2 SMARCA4 MARK2 MX1 REC8 LY6E OAS3 AKAP1 IFIT1 IFI35 AP3D1 MX2 NFATC2IP XAF1 ZNF609 HERC6 HMGXB3 LGALS3BP CMTR1 UBE2D4 OASL PML SBF1 CHST12 SMG1 IRF7 ADAR PARP2 ILF3 DCAF15 IFI44L PSME2 EIF4G1 OAS1 SMG7 C16orf58 SPATS2L CHD4 ACTN4 ST3GAL5 OAS2 ESF1 DDX60 KCTD14 PARP12 RPL28 IFIT3 IFI44 BPTF OARD1 RHBDD3 TYMP SON STIL EIF5B GART MLEC GPATCH8 RTP4 MED15 SART3 THOC2 IFIH1 JUP EIF2AK2 IDH2 UBE2L6 IFITM1 HERC5 GLG1 PABPN1 COX8A SLC25A11 DESI2 TNIK RFWD3 N4BP1 MED24 KPNB1 PRR5 CD2AP IRF9 ZNF264 TRIM14 TRIM22 ABL1 TRANK1 PURA NUP62 up
## GSE24634_TREG_VS_TCONV_POST_DAY3_IL4_CONVERSION_UP 0.0012330 0.0087574 0.5258061 2.369398 0 182 NUDCD3 POLR3K CRCP WRAP73 POLD2 LIF PWP2 MCAT NTHL1 NOC4L TSR3 ISG20L2 NCAPH2 SLC7A5 EIF3I NPRL3 PTBP1 RAD50 UBAP2 ENO1 RPUSD2 LONP1 DUS1L CDT1 ATP6V0E2 HAUS5 NOL9 UBE2M MRPL17 PRMT5 SPAG1 FIBP ATIC POLE EZR PRPF8 NOLC1 NCL IFT57 NUP93 NMT1 RUVBL1 SRM HNRNPAB PFDN2 AKAP8 EIF2B3 SNRPD3 TACC3 MRPL24 NVL POP7 IMP4 POLDIP3 SGTA LSM4 SUPT16H EXOSC2 PMPCA CIAPIN1 PLK1 DDX39A BCL2L1 PMAIP1 CTPS1 CCT7 MRPL23 BZW2 RBM28 LIG1 CS AGO2 TMEM184B HINT1 DTYMK FBXO41 FAM136A C1QBP MRPS12 MAGOH CDCA8 CCT2 MCPH1 TSFM TUBB4B TARBP2 TTC26 TMEM106C ILF2 SRRD PABPN1 up
## GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP 0.0012469 0.0087574 0.5270084 2.362302 0 176 ACD EIF3B ATP13A2 AMBRA1 SCMH1 SRRM2 POLR3E FAM160B2 GEMIN4 ABCF3 CHD8 INHBE KPNA6 ARHGAP32 TSC2 SIM2 BRD9 RUSC1 TRPC4AP PLXNB2 MEN1 DDX27 BRD4 RNF216 CNKSR1 SPG7 EP300 ANAPC2 EPS8L2 ZNF500 LUC7L CLCN7 TEAD3 ERAL1 HDGF SUPT6H CAMK1D ACIN1 SZT2 TFIP11 IDUA PNKP TRRAP TPCN1 SIN3B NAT10 HDAC7 TCF20 MADD CELSR1 POLR2E POGK ERBB2 ZC3H4 FAM222B MOGS DAZAP1 APLP2 PPP2R5B DCTN1 COG2 ZNF79 TESK1 PRKAB1 ERC1 LIPE TCOF1 KLK10 KDM1A PMP2 MED12 POLR2A DSN1 JUP PLOD1 ERCC3 C6orf62 BRF1 TMEM132A TYMS ELK1 SRSF9 DESI1 CCDC51 NFIC NISCH AFF4 C11orf24 up
## GSE43863_TH1_VS_LY6C_INT_CXCR5POS_MEMORY_CD4_TCELL_UP 0.0012210 0.0087574 0.5219353 2.361774 0 186 MFHAS1 NOP9 TBL3 TMEM238 MTOR KCTD13 HMGA1 UTP14A TRNAU1AP SF3B3 SLC7A6 MLLT1 GLS ABCF2 MRPS2 AIMP2 WDR55 GEMIN4 NSUN2 GRWD1 WIZ RRP9 SLC25A33 PDF NLE1 THOP1 PSMB2 MTRR DDX31 C7orf50 WDR18 ARFRP1 GMEB2 LUC7L INTS4 PNPT1 DDX56 GPS1 ATIC CLIP1 PELP1 RABGGTA RABL6 ATXN7L3 AATF RUVBL1 SRM B4GALT5 RUVBL2 CCNB1IP1 ECE2 EIF2B3 NAT10 TADA2A RRP7A LMNB2 PUS1 PDAP1 ZC3H12A SMYD5 STOML2 URB2 TRMT6 IFNLR1 WDR4 CTPS1 SLC9A8 FOXRED2 CPSF4 ELAVL1 TRIM44 TSEN54 IDH3A PPP5C TMEM184B DNAJC2 HOMER1 NFKBIB ICAM1 CFLAR POLR3D WDR5 CCT6A UTP6 PXN PTCD3 MYO19 UMPS CHAMP1 LSM12 BRIX1 RBM17 TSEN2 CCDC6 PTPMT1 POP1 up
## GSE27434_WT_VS_DNMT1_KO_TREG_UP 0.0012438 0.0087574 0.5250556 2.358935 0 178 RERE JMJD8 UBE4B GTF3C1 LYPLA2 RBCK1 FAF1 GUK1 AKAP1 FASTK CDCA7L GNAS ZFYVE19 CDC37 CSNK1G2 RAD50 RPS5 TMEM259 PSMD3 ENO1 LMF1 EFNA1 DFFA ESRRA OGDH HRAS TM7SF2 CDT1 DDX27 BAK1 NR2C2AP SNRPB CLTA LRP10 CIAO1 GOLGA3 STX18 TFIP11 ZNF276 PNKP RPP25L DAP SLC38A10 NDUFS3 MKNK2 CLN6 YIPF3 SLC39A3 BCAT2 SEC24C SLC50A1 SYT17 ANKZF1 XRCC1 RPL19 RPS6KB2 RPL28 PTOV1 MFSD5 PRKCSH TMEM179B CDK4 NUBP1 TYMP PAM PCK2 ZNF574 RAB4A YIF1A RNF26 RPL34 JOSD2 SCNM1 PAFAH1B3 LMAN2 RPS23 SLC6A13 SART3 KCNK1 MRPS12 ANAPC11 FGF12 up
## GSE6674_ANTI_IGM_VS_ANTI_IGM_AND_CPG_STIM_BCELL_DN 0.0012255 0.0087574 0.5223480 2.356621 0 184 NOC2L ATAD3A DNAJA3 EIF3B TBRG4 SESN2 CCDC86 POLD2 BMS1 TRIB3 YDJC GNL2 NIP7 NOC4L CDCA7L LRP8 SLC7A5 MYBBP1A FAM118B ZMYND19 NOP2 FARSB GEMIN4 CYB5A PRMT1 NLE1 NDUFAB1 C7orf50 NOL9 CLPTM1L GPS1 ATIC EBNA1BP2 NOLC1 SRM RRP1B EIF2B3 HSPA9 BDH1 HOOK1 EIF3G LARP1 EXOSC2 SMYD5 CHAC1 DDX54 SNHG17 PPAN SMYD2 KCNK5 UTP18 BCL2L1 BOP1 CTPS1 XPOT SPATA5L1 ELAVL1 ASNS CCT3 SPRED1 PIM3 FNIP2 BTG3 ZNF608 IDH3A CHCHD4 SNRPA PHB AGPAT3 AEN SND1 HOMER1 NHP2 GCSH C1QBP TMCO3 ACLY TUT1 GADD45G up
## GSE14000_TRANSLATED_RNA_VS_MRNA_DC_DN 0.0012547 0.0087574 0.5308627 2.352869 0 160 SSU72 ZDHHC4 TRAF7 TRAPPC3 ADAP1 TMEM222 ATP6V1C2 RPUSD1 GUK1 RPLP0 RPS5 GDE1 NDUFB10 JTB LAMTOR1 RPLP1 HPCA RPS3 CISD3 DEAF1 C7orf50 RPL36 TMEM219 RPSA TMEM134 RPL12 RPL18 ARPC1A RPL35 ZNF32 KDELR2 RPL13A C4orf48 RPS12 SLC25A51 RPLP2 RPL11 STX10 DAP PDIA2 RPL32 POP7 RPS14 RPS11 B4GALT7 EEF1D ZNF688 YPEL3 EPHB4 SSNA1 SLC29A4 RPL19 CPSF4 IGBP1 AP5S1 EIF3L HOXB1 DNAJC22 FOXB1 RNF7 C2orf68 PABPC4 RPS15A RPL8 LSM10 RPL30 BCL7C SLC9C2 ZNF511 PTPN18 ZFYVE21 GPX4 RPL39L RPL23 RPL4 LSM12 IMPDH2 RPL23A RPS13 EEF1B2 ANKRD39 ORAI2 NDUFAF3 SERP1 RPS6 TP53TG1 BATF3 SDF2L1 OST4 TMEM141 SLC4A5 MAPK11 BRI3 SPG21 SYS1 TMEM147 PRMT2 LZIC DUSP23 up
## GSE14908_ATOPIC_VS_NONATOPIC_PATIENT_RESTING_CD4_TCELL_DN 0.0012346 0.0087574 0.5226304 2.352603 0 180 AURKAIP1 CRCP SH3RF1 ADRM1 BMS1 PWP2 MPI FZR1 GNL2 LRWD1 ZNHIT2 GUSB EIF3I CLPB MLLT1 ZMYND19 IDH3B NSUN2 NXN KPNA6 TBC1D24 RAI14 WIZ RPL24 TNIP2 RNPEP POLRMT BNIP1 NDUFB2 GLOD4 COX19 UQCRC2 AATF GATAD2A MFSD10 NDUFS3 EXOSC5 CD320 BDH1 NELFB PSPH STT3A EXOC8 WDR4 HDLBP NDUFS4 PSMC4 ELAVL1 SPRED1 OARD1 GALNT3 PRPS1 MRPS23 RBM28 HIVEP3 C2CD2L SURF4 RNF26 SSBP1 NASP NMNAT1 POLR2H CYB5R1 FANCG UPP1 FBXW8 RBM19 TMEM216 ACLY SRP54 CLASP1 DHODH COA6 R3HCC1 LSS OXCT1 WFS1 FBL COX8A GLRX3 LANCL2 ALAD EIF2D C11orf24 NDUFA11 COX6B1 EIF3A up
## GSE28737_FOLLICULAR_VS_MARGINAL_ZONE_BCELL_UP 0.0012225 0.0087574 0.5180067 2.345093 0 187 TYW1 RER1 COA4 MECR DHDDS YDJC NADSYN1 ECI1 MIB2 ZNF496 WDR55 LAMTOR1 LMF1 DNASE1L2 MEN1 ZDHHC9 RAB11FIP5 TTC38 RPL18 CLPTM1L ZNF692 TSC22D4 KLHDC2 ATIC CCAR2 ZDHHC16 ENTPD5 GDPD3 TMEM203 MGME1 XPR1 RNF187 KATNB1 PPRC1 METTL1 LMNB2 LCLAT1 LZTR1 PDSS2 EMC10 FBRSL1 SUMF2 IMP3 CTCF FAM98C NPEPL1 P4HTM VPS16 PRMT3 DHX34 TXNDC11 TNRC6A TARS2 ANKRD52 RAD51D MRPL23 MRPL33 QTRT1 DUSP12 GORASP2 POLR1A PYGB JOSD2 EIF2B4 RPS16 TEN1 FBF1 DTD1 PIGV SMPD2 PSAT1 SCAP TRAF3IP1 MBTPS1 TMC6 TEF PON3 C12orf65 SLC6A13 SLC1A5 POLH TBC1D14 SPIRE1 HDAC10 PPP2R1A TMEM223 ARHGAP39 FPGS PREB TMEM106C LSS PLEKHG3 TTC13 up
fgsea_plot(fgsea_res$res_msg, pathways_title='All signatures', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
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## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0013316 0.0088814 0.7421987 3.149826 0 105 PRSS33 C16orf91 JMJD8 SNRNP25 TRAF7 NME3 TBL3 PRSS22 POLR3K RAB11FIP3 TELO2 METRN WDR24 PAQR4 MRPS34 AXIN1 SRRM2 RHBDF1 RPUSD1 FLYWCH2 GFER UBE2I PRSS27 WDR90 MPG ZNF598 NTHL1 STUB1 CAPN15 TSR3 NPRL3 KCTD5 DECR2 RHOT2 HAGH NUBP2 NME4 NDUFB10 PIGQ EME2 THOC6 TNFRSF12A KREMEN2 TSC2 LMF1 GNPTG CHTF18 RPS2 ZG16B WFIKKN1 ZNF205 MRPL28 MAPK8IP3 RAB40C SOX8 C1QTNF8 IFT140 LUC7L CLCN7 RHBDL1 ZNF213 CLDN9 HAGHL FAHD1 HS3ST6 PDIA2 FBXL16 up
## GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 0.0011614 0.0088814 0.6485693 3.121102 0 308 SUN1 RNF207 ATAD3A SLC52A3 ATAD3B EIF3B FBXO44 RNPS1 MTOR KCTD13 SRRM2 SNHG3 CC2D1B SMARCA4 GAS5 MARK2 GFER TBC1D22B FBXL19 RCC1 TMEM201 FNBP4 ZNF598 CAPN15 REXO1 MIIP SRCAP EVI5L SETD1A INTS1 ZMYND19 KAT8 CSNK1G2 LSM14B ATXN2L PTBP1 FBXL18 XPO5 PHKG2 RTKN ZNF646 POLM STK11 TMEM259 HIP1R ZC3H7B CMTR1 SRRT TMEM63A AGRN ABCF3 MDN1 SMG5 HHLA3 TICAM1 ANKRD54 NSUN4 PPP1R12C HSF4 TRMU HPCA CACTIN SNAPC4 LRCH4 PPP6R2 SCAF1 MAPK8IP3 TRABD CDC42EP1 COPS7B L3MBTL2 TNPO2 TARDBP MAP2K2 PIP5K1A AP5Z1 CPSF7 GIGYF1 ZNF316 IL17C PICK1 TMEM86B RPL18 TNPO3 EPN1 ZNF692 TEAD3 SF1 CCAR2 RANGAP1 GRIPAP1 ZBTB7B PDXP PPM1G UBAP2L DAGLB KLF16 ACIN1 LTB4R RHBG SBNO2 BRD1 SZT2 C7orf26 ILF3 GATAD2A TRRAP GBA2 ARMC6 APBA1 AMPD2 SH3BP5L U2AF2 EYA3 CLASRP HDAC7 MYPOP PPRC1 SFSWAP ZNF133 PUS1 KMT2D KDM4A LMNA ARHGEF11 KHSRP NPIPB3 LARP1 R3HDM4 SMG7 RBM33 SGSM3 DOT1L LEMD2 GPC2 SLC39A3 USP21 SLC12A9 MICALL1 ZMIZ2 FBRSL1 ZNF202 CSNK1E ABCA7 TAF1C MOGS LPAR2 DHX33 URB2 KCNK5 FANCA GGA1 PHF5A DAZAP1 SUGP2 PPARD SPPL2B POLR2F AP5S1 ARHGEF2 UQCC2 NEURL4 RASSF7 ZNF444 CTNND1 NUP214 QTRT1 NPM3 HAUS8 TCOF1 DENND4B MEF2D CIC GRAMD4 FXR2 TNK2 NSUN5P1 ERCC2 SAFB2 ANKRD13D SNRNP70 HIRA TCF3 MYO9B B4GALT1 THOC2 CNTROB ARPC5L HDAC10 TCHP MAPRE3 MSTO1 RBM14 TECPR1 APBA3 LLGL1 TPM2 GLP1R ABCC10 SMARCD1 PABPN1 SPON2 TTC13 MCTP2 up
## chr16p13 0.0011834 0.0088814 0.6532959 3.095014 0 272 PRSS33 C16orf91 PDXDC1 GLYR1 PRSS41 UBN1 DNAJA3 JMJD8 SNRNP25 TRAF7 PGP NME3 CARHSP1 TBL3 PRSS22 E4F1 POLR3K GSPT1 RAB11FIP3 HMOX2 TELO2 MLST8 RNPS1 METRN WDR24 ADCY9 PAQR4 MRPS34 AXIN1 SRRM2 NOMO1 RHBDF1 RPUSD1 PDPK1 FLYWCH2 GFER UBE2I PRSS27 CLEC16A WDR90 MPG ZNF598 NTHL1 ZNF174 NMRAL1 STUB1 ZC3H7A CAPN15 TSR3 PPL ECI1 NPRL3 KCTD5 CCDC154 NTN3 MGRN1 ANKS3 PMM2 DECR2 RHOT2 MPV17L SLX4 SMIM22 HAGH NUBP2 NME4 NDUFB10 PIGQ BRICD5 EME2 THOC6 TNFRSF12A CREBBP TBC1D24 KREMEN2 TSC2 LMF1 GNPTG DNASE1L2 CHTF18 RPS2 ZG16B METTL22 WFIKKN1 ZNF205 ALG1 MRPL28 MAPK8IP3 NUDT16L1 RSL1D1 RRN3 RAB40C ZNF263 SOX8 COX6CP1 C1QTNF8 IFT140 TMEM186 ZSCAN32 ZNF500 LUC7L RMI2 CLCN7 RHBDL1 ZNF213 SNHG9 SNORD60 DNASE1 NAA60 CLDN9 MTRNR2L4 HAGHL ABCC1 OR1F1 FAHD1 HS3ST6 PDIA2 ABAT MIR3180-4 PKD1P6 FBXL16 ZNF597 PARN MIR5587 TRAP1 UBALD1 GLIS2 WASH4P C16orf90 USP7 IMPDH1P11 WASIR2 IL9RP3 SLC9A3R2 ROGDI TXNDC11 HCFC1R1 PKD1 AMDHD2 TEKT5 C16orf72 TFAP4 NPIPP1 PKMYT1 NOMO3 UNKL NPIPA1 BFAR NUBP1 ERVK13-1 CCNF TPSP2 IGFALS TIGD7 CLUAP1 GRIN2A MIR4718 FOPNL MIR3176 up
## chr1p36 0.0011111 0.0088814 0.6192226 3.034614 0 395 SNORA59A ISG15 SSU72 RERE GALE SPEN CEP104 NOC2L DHRS3 VPS13D RNF207 AURKAIP1 DNAJC11 ATAD3A KLHDC7A DNAJC16 MRPL20 FBXO42 RER1 UBR4 PEX10 ATAD3B B3GALT6 DVL1 C1orf174 ATAD3C CDK11B ATP13A2 UBE4B PUSL1 MFN2 NPHP4 FBXO44 DHDDS SMIM1 UBE2J2 ARHGEF16 SRRM1 MTOR NADK WRAP73 PANK4 LYPLA2 LRRC47 ZBTB48 EIF4G3 GPN2 ZBTB17 TMEM222 AKR7A2 PHF13 VWA1 SDF4 DDI2 CCNL2 PLEKHN1 TMCO4 MRTO4 CASZ1 RCC2 RNU6ATAC18P TMEM201 NBPF3 EXOSC10 HES4 KIAA2013 MIIP FBXO2 MIR34A C1orf159 KIF1B ARHGEF10L ARHGEF19 EMC1 CDK11A PGAM1P11 ICMT AKR7A3 RN7SL574P CROCCP3 MIB2 CLCNKB SLC9A1 NR0B2 MST1P2 ARID1A AGRN RNF223 TP73-AS1 CROCCP2 LINC00337 ENO1 PEX14 LDLRAP1 CEP85 SZRD1 MTFR1L GRHL3 NIPAL3 NUDC PRDM16 SLC25A33 DFFA MAP3K6 UBIAD1 OTUD3 LINC00339 SDHB TNFRSF25 PARK7 MAD2L2 MMP23A DDOST CNKSR1 GPR157 TARDBP PER3 NOL9 MUL1 ACAP3 TRNP1 MIR429 SCNN1D MORN1 KLHL17 TPRG1L EPHA2 RPL22 CALML6 RPS6KA1 RHCE THAP3 ASAP3 WDTC1 CTNNBIP1 HES5 SRM MTND2P28 TCEA3 RPL11 SLC35E2B PDIK1L ALDH4A1 SKI TMEM51-AS1 CLSTN1 PAFAH2 MEGF6 LINC00115 AGTRAP CLCNKA PRDM2 ESPNP AKR7L NPPA STPG1 TMEM52 ANKRD65 PINK1-AS TNFRSF18 OSTCP2 IFNLR1 HMGCL CD164L2 MIR4689 RNU6-1265P DRAXIN FAM131C TMEM88B MIR200A FUCA1 CLCN6 FBXO6 ZBTB40 PLEKHM2 PAQR7 IFFO2 IL22RA1 NCMAP EPHB2 SLC45A1 UBXN10 NBPF2P GNB1 AUNIP PRKCZ TMEM82 KDM1A NBPF1 SYTL1 MST1L PLEKHG5 NMNAT1 PINK1 PIGV H6PD DFFB ACOT7 PITHD1 MTHFR MXRA8 MTATP6P1 CROCC TTLL10-AS1 MIR200B RN7SL614P GPATCH3 CROCCP5 RN7SKP269 TP73 TMEM240 ECE1 MIR4684 PLA2G2C TMEM51 PLOD1 MMEL1 TNFRSF14 CICP27 CHD5 AGMAT TTC34 up
## WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP 0.0011820 0.0088814 0.6421231 3.030904 0 256 GALE AURKAIP1 BAIAP2L1 GIPC1 TMC5 GSS STARD10 SMARCA4 TTLL12 CHMP1A TMEM30B MYO10 PACSIN2 MYO6 MRPS18A NADSYN1 RASEF ST14 ICA1 CIB1 ZGPAT RAB25 TMEM259 HIP1R TMEM63A JTB SLC35A3 MRPL14 MVP GFPT1 RRBP1 CHMP4C EIF2B5 TACSTD2 TNIP2 SLC22A23 RABEP2 MROH1 HDAC1 VPS37B SCAMP2 SART1 RNF128 TSTA3 ARRDC1 TTC22 CC2D1A EPS8L2 FDFT1 CLPTM1L AGR3 ELF3 SLC2A10 EPCAM AGR2 KDELR2 ESRP2 SRPK1 NET1 DDAH1 IFI27 RPS6KA1 ZMYND8 RABL6 PREP C1orf116 FRK RNF126 PLEKHJ1 TOX3 TRAF4 GNA11 DOK4 GSTK1 DOHH OVOL2 CANT1 VSIG2 MRPL41 C1GALT1 MT-ATP6 POP7 TUBA4A RRP7A DNAJB2 MED16 EIF4G1 FUT2 IL20RA MKNK2 OXLD1 PLS1 TOMM40 MLPH TJP3 SGPP2 SGSM3 GRTP1 RALY GPR160 MGLL CTBP2 QSOX1 EDF1 EPHB4 PSMB10 CRB3 HDLBP GOLGA2 ARHGAP27 STYK1 AACS CCDC107 TSPAN8 ABHD17C MRPL52 NOSIP ERBB3 BZW2 MARVELD2 EHF ABCC3 FNIP2 TRAK1 GALNT3 SIRT7 VSIG10 MLLT6 BPHL ETFB BTBD3 ESRP1 PSD4 BSPRY EIF5B LRRC8B PPIA PWWP2B SH3BGRL2 LMAN2 F11R CCND1 TMEM129 TOP1 MANSC1 TMC6 UQCRQ LSM7 TMEM125 MUC1 MPST PPDPF up
## CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 0.0011050 0.0088814 0.6068748 2.983783 0 406 USP18 SUN1 PDXDC1 SLC52A3 JMJD8 NME3 GSPT1 AAGAB IQCE KIAA0319L PAQR4 STARD10 KIAA1522 RHBDF1 DDI2 TRIB3 FAAH TTC39A MARVELD3 CASZ1 TMEM30B KIAA0556 NR2F6 SH2D3A MYO6 CNNM4 TMPRSS2 ISG20L2 TFF1 RASEF EXPH5 GGCT DAAM1 ST14 ICA1 TLE3 EPS8L1 DLG3 ZXDC SLC29A2 RAB25 HIP1R SHANK2 LSR SIGIRR SLC37A1 CYB5A JTB EPHA1 SPATA2L TMEM184A CYB561 ANK3 TMED3 COG7 CHMP4C ARHGEF5 ZG16B SLC25A29 CGN DEGS2 RABEP2 FAM214A MYO5C LAD1 RUSC1 SCAMP2 HOOK2 TM7SF2 TRPM4 CDH1 RAB40C EPN3 UBQLN4 ARRDC1 MSX2 ARFIP2 RMND5B TMEM134 GPR157 MACC1 C6orf132 SPINT1 LMTK3 MAP7 PGAP2 HID1 ELF3 CACNA1D PRSS8 EPHB3 EPCAM AGR2 BCR PPP1R16A SEPHS2 ZBTB7B ESRP2 TMPRSS13 FOXA1 PRLR OVOL1 TNKS1BP1 PRR15 RBM47 MPP7 FAM110A ZNF74 ELMO3 ZHX2 TOX3 AP1M2 IGFBP2 GRHL2 PKP3 ALDH4A1 TRAF4 FREM2 RHPN1 SH3YL1 INPP5J GRHL1 TSTD1 ABAT CAMSAP3 OVOL2 MRPL41 ARFGAP2 TFF3 SFI1 RAB11FIP4 PROM2 PATZ1 MYO5B CBLC TADA2B MKNK2 ZBTB42 HOOK1 ERBB2 MLPH TJP3 ZNF467 EFNA4 OCLN TMEM45B SERINC2 MYH14 DOK7 DBP GPR160 LNX1 SSH3 MYO1D CDH3 PPM1H P4HTM GPD1L CDS1 TTC9 PPP2R5A TMEM191A ENTPD2 TBC1D30 FLAD1 ROGDI MAL2 TMEM183A PER2 PLEKHA6 MRFAP1L1 C1orf43 SLC9A3R1 CADPS2 BIK PRR15L ENSA IRF6 ERBB3 MARVELD2 EHF CAPN8 CSAD TPD52L1 DHRS13 SPINT2 PCK2 NOL3 PPCS GOLT1A RAB17 ESRP1 SYNE4 MCCC2 BSPRY AZGP1 ABCA12 DCAF11 ANXA9 KIFC2 GGT6 MUCL1 KIAA1211L PGAP3 PAGR1 GRAMD4 PWWP2B SYTL1 KRT19 KIAA1324 MGMT ARHGAP8 TNK2 SUCO FAM102A F11R CERS6 MPZL3 TMEM125 MUC1 TSPAN1 SCYL3 CKMT1B ENPP5 PPDPF GRB7 ULK1 VRK3 CHMP2A CLDN7 ELL3 PLCH1 JUP MMEL1 TSPAN13 LLGL2 SELENBP1 CCDC97 IDH2 DNAJC1 TMEM79 FANCF DDR1 RAB27B ALDH3B2 C4orf19 WFS1 CCDC6 PPP1R3D TMEM41A FXYD3 NPDC1 ABCC11 SYMPK RALGPS1 SORL1 ZNF385A PLXNA3 ZKSCAN1 MREG PRRG4 up
## REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION 0.0013624 0.0088814 0.7080354 2.910071 0 86 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 EEF1A2 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 EEF1D RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 EEF2 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 EEF1B2 up
## COLDREN_GEFITINIB_RESISTANCE_DN 0.0012240 0.0088814 0.6289971 2.893216 0 206 KCNMB4 SPINK2 TMC5 PRSS22 ADAP1 STARD10 KIAA1522 MARVELD3 GUK1 TMEM30B MYO6 GNAS STAP2 RASEF WLS PPL EXPH5 TMEM54 ST14 EPS8L1 MBOAT1 RAB25 SMIM22 LSR LRG1 SLC35A3 EPHA1 ADK CST6 GRHL3 STK39 CGN TACSTD2 MROH1 LAD1 SCAMP2 CDH1 EPN3 CNKSR1 TTC22 MACC1 EPS8L2 C6orf132 SPINT1 SMAGP MAPK13 ELF3 PRSS8 AGR2 ESRP2 OVOL1 RBM47 RHOD MPP7 CLDN9 FAM110A ELMO3 LIPH C1orf116 AP1M2 ERP27 GRHL2 PLEKHA7 KLC3 SH3YL1 GRHL1 RNF114 OVOL2 RAB11FIP4 B3GNT3 SLC1A1 TBC1D8B TJP3 SYTL5 TMEM45B KANSL1-AS1 MYH14 DOK7 GPR160 LNX1 TJP2 MYO1D QSOX1 CDH3 VAMP8 CDS1 HMGCL CYP2J2 HS3ST1 MAL2 MST1R PITPNM3 BIK PRR15L IRF6 ERBB3 WEE1 EHF CCDC57 SPTLC3 CAPN8 GALNT3 PRRG2 SVIL REPS2 SMIM5 PSD4 SYNE4 RIPK4 BSPRY ANXA9 PTK6 KIAA1211L SYTL1 KRT19 SH3BGRL2 MPZL3 AIG1 TMEM125 TSPAN1 ENPP5 MFSD6 CLDN7 LIMA1 up
## KEGG_RIBOSOME 0.0013928 0.0088814 0.7063876 2.873974 0 81 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL41 RPL23 RPL4 RPL23A RPS13 up
## REACTOME_RRNA_PROCESSING 0.0012300 0.0088814 0.6311146 2.870182 0 184 NOB1 TBL3 UTP14A BMS1 PWP2 EXOSC6 NIP7 RPL13 NOC4L TSR3 ISG20L2 EXOSC10 PES1 RPS21 NOP2 RPLP0 NOP14 RPS5 NOL6 RPP25 RPL24 RRP9 NSUN4 RPS2 RPLP1 RPS3 DHX37 RPL36 RPL10A WDR18 RPL39 RRP1 RPSA NOL9 RPL18A RPL12 RPL18 ERI1 RPL35 RPL29 EBNA1BP2 RPL22 RPL13A LAS1L RPS12 NCL PELP1 NOP56 RPS28 RPL3 TRMT112 DDX49 RPLP2 RPS15 RPL11 FAU NAT10 TSR1 RPL32 RRP7A EXOSC5 RPS14 RPS11 IMP4 RPL38 EXOSC2 CSNK1D CSNK1E RPS20 IMP3 RPS29 MPHOSPH10 RPL37A UTP18 RPL31 HEATR1 RPS27 BOP1 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPS8 RPL37 WDR3 RBM28 RPS7 FTSJ3 RPL34 RPS16 RPS15A RPS26 RPL8 UTP3 RPL35A NHP2 RPS4X RPS27A RPL30 UBA52 UTP20 RPS23 RPL14 RPP38 ELAC2 UTP6 NOL12 RPL39L RPL41 RPL23 up
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0012270 0.0088814 0.6274850 2.864624 0 187 NOC2L AURKAIP1 UBN1 TBL3 E4F1 AMBRA1 SRRM1 TAF4 POLD2 ADRM1 ZBTB17 OSBPL2 TSR3 DNAJC17 NADSYN1 SLC7A5 CDC37 SLC2A4RG LRRC41 SF3A2 MRPS2 PTBP1 ZNF512B TMEM259 SIGIRR PEF1 SLC25A22 ABCF3 THOC6 XAB2 VPS51 PPP6R2 HRAS SART1 TSTA3 AAMP RPL36 COPS7B WDR18 PRCC ANAPC2 BRMS1 AP5Z1 UBE2M SSRP1 LPCAT4 TRIM28 STK25 NAA60 ATP13A1 CFDP1 C9orf16 RPLP2 PRPF19 DCAF15 GATAD2A GADD45GIP1 RPL11 PFDN2 NONO FOXK2 TACC3 U2AF2 VPS9D1 TAF10 MFSD10 HMG20B EXOC7 HSPA9 POLR2E PDAP1 EEF1D NELFB MARCKSL1 CDCA4 FUS RALY CCS TAF1C RRS1 EDF1 MRPL12 PSMB10 DRAP1 THAP7 GCDH SMARCD2 RPS27 DAZAP1 CCDC85B TP53 SH3GLB2 PDIA4 RPL37 QTRT1 IRF3 SPINT2 DGKZ TRAPPC2 RALGDS COPG1 STARD3 PAF1 UBE2S NFKBIB PIN1 SAFB2 FBXO41 ABHD17A SNRNP70 BANF1 ATP1A1 TNFRSF14 NDUFC1 LSM12 IMPDH2 APBA3 TSSC4 CLPTM1 SIPA1 SAFB SRSF9 TMED9 up
## REACTOME_NONSENSE_MEDIATED_DECAY_NMD 0.0013193 0.0088814 0.6711097 2.862577 0 108 GSPT1 RNPS1 RPL13 RPS21 RPLP0 RPS5 SMG5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 SMG1 RPL35 RPL29 RPL22 RPL13A UPF3B RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 EIF4G1 RPL38 SMG7 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 UPF1 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL39L MAGOH RPL41 RPL23 RPL4 PPP2R1A RPL23A RPS13 up
## GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 0.0013158 0.0088814 0.6633931 2.849826 0 114 HELZ2 GSPT1 RNPS1 RPL13 EXOSC10 RPS21 RPLP0 RPS5 SMG5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 SMG1 RPL35 RPL29 RPL22 RPL13A UPF3B RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 RPL32 RPS14 RPS11 EIF4G1 PARN RPL38 SMG7 RPS20 RPS29 RPL37A RPL31 DHX34 RPS27 RPL27A RPL19 RPL28 UPF1 RPL9 RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 MAGOH RPL41 RPL23 RPL4 PPP2R1A RPL23A RPS13 up
## REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0013351 0.0088814 0.6665552 2.824476 0 104 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 DDOST RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 SSR2 RPS27 RPL27A RPL19 RPL28 RPL9 SEC61G RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A SRPRB RPL30 UBA52 RPS23 SRP68 RPL14 SRP54 RPL39L RPL41 RPL23 RPL4 RPN2 SEC61A1 RPL23A RPS13 up
## REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY 0.0013587 0.0088814 0.6792534 2.821856 0 94 TRIB3 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 DDIT3 RPS15 RPL11 FAU RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 ASNS RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 ATF4 RPS3A RPS6 RPL5 RPL26L1 CEBPB EIF2AK4 RPS24 up
## GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 0.0012853 0.0088814 0.6340206 2.821528 0 152 MRPL20 MRPS34 RPL13 MRPS18A MRPL55 RPS21 MRPS2 RPLP0P6 RPLP0 MRPS15 RPS5 MRPL14 RPL24 MRPL49 RPS2 RPLP1 RPS3 MRPL28 RPL36 DAP3 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 MRPL17 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 RPL38 MRPS35 MRPL4 RPS20 MRPS33 MRPL12 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 MRPS7 MRPL23 RPL9 MRPL52 MRPS6 MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MRPS23 RPS7 RPL34 MRPL21 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 MRPL10 RPL14 MRPL27 MRPS12 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 MRPL36 up
## REACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS 0.0012642 0.0088814 0.6257830 2.804445 0 159 PSMC6 GSPT1 LHX9 RNPS1 RPL13 RPS21 RPLP0 RPS5 ISL1 PSMD3 RPL24 RPS2 RPLP1 LHX2 RPS3 PSMB2 PSMD11 RPL36 PSMC3 RPL10A RPL39 RPSA PSMA5 RPL18A RPL12 RPL18 RPL35 RPL29 PSMA7 RPL22 RPL13A UPF3B RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU PSME2 RPL32 PSMA6 RPS14 RPS11 EIF4G1 PSMB5 LDB1 RPL38 PSMA3 RPS20 PSMB10 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 PSMC4 RPL9 SLIT1 PSMD4 RPL36AL PSMF1 RPL27 RPS8 RPL37 RPS7 PSME3 MSI1 RPL34 RPS16 RPS15A RPS26 PSMC1 RPL8 ZSWIM8 RPL35A RPS4X RPS27A PSMD12 RPL30 PSMD2 UBA52 DAG1 RPS23 RPL14 PSMD13 PSMB4 RPL39L MAGOH RPL41 RPL23 RPL4 PSMC5 RPL23A RPS13 up
## GO_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0.0013587 0.0088814 0.6747627 2.803200 0 94 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 SSR2 RPS27 ZFAND2B RPL27A RPL19 RPL28 RPL9 RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 SRP68 RPL14 SRP54 RPL41 RPL23 RPL4 SEC61A1 RPL23A RPS13 up
## REACTOME_INFLUENZA_INFECTION 0.0012953 0.0088814 0.6310041 2.795702 0 145 ISG15 KPNA7 RPL13 RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 POLR2L POLR2J CLTA RPL22 RPL13A RPS12 RPS28 RPL3 NUP93 RPLP2 RPS15 NUP205 RPL11 GTF2F1 FAU RPL32 RPS14 RPS11 POLR2E RPL38 RPS20 RPS29 NUP88 RPL37A RPL31 TPR POLR2C RPS27 RPL27A RPL19 RPL28 CPSF4 POLR2F RPL9 NUP160 RPL36AL RPL27 RPS8 RPL37 NUP214 RPS7 RPL34 NUP133 GRSF1 RPS16 RPS15A RPS26 RPL8 RPL35A POLR2H RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 POLR2A NUP188 NUP85 RPL39L RPL41 EIF2AK2 RPL23 RPL4 RPL23A RPS13 PABPN1 RPS3A NUP98 NUP107 NUP210 POM121C AAAS POLR2I KPNB1 RPS6 RPL5 RPL26L1 NUP50 up
## REACTOME_METABOLISM_OF_RNA 0.0010616 0.0088814 0.5549670 2.789492 0 626 TYW1 SRSF4 EDC4 RPPH1 SNRNP25 NOB1 TBL3 PSMC6 CTU2 GSPT1 SRRM1 RNPS1 USP39 PRPF6 SRRM2 MNAT1 CD2BP2 UTP14A BMS1 PWP2 EXOSC6 SF3B3 NIP7 RPL13 EDC3 NOC4L TSR3 ISG20L2 EXOSC10 CWC25 PES1 CHERP AKT1 RPS21 METTL3 PUS7 NOP2 GTPBP3 SF3A2 PTBP1 TRMT61A RPLP0 SNRNP200 NOP14 RPS5 TRMT1 GEMIN4 SRRT CTU1 PSMD3 THOC6 SMG5 NSUN2 NOL6 TRIT1 XAB2 RPP25 RPL24 RRP9 NSUN4 RPS2 TRMU RPLP1 RPS3 PSMB2 PSMD11 DHX37 DHX38 SART1 TRMT12 RPL36 PSMC3 ADAT1 RNPC3 RPL10A WDR18 RPL39 RRP1 NXT1 RPSA PSMA5 LSM5 PRCC CLNS1A NOL9 RPL18A CPSF7 RPL12 RPL18 SMG1 ERI1 RPL35 SF1 SNRPB PRMT5 RPL29 EBNA1BP2 POLR2L PSMA7 POLR2J TNKS1BP1 CSTF2 RPL22 RPL13A DDX23 ADAR PRPF8 LAS1L UPF3B RPS12 NCL PELP1 NOP56 RPS28 RPL3 TRMT112 SRSF1 NUP93 DDX49 TFIP11 RPLP2 RPS15 NUP205 PRPF19 RPL11 TP53RK SF3B2 SF3A3 GTF2F1 FAU NAT10 TSR1 SNRPD3 DDX46 U2AF2 TRMT44 PSME2 RPL32 POP7 RRP7A EXOSC5 PSMA6 RPS14 CDC5L METTL1 RPS11 EIF4G1 POLR2E TXNL4A PSMB5 ALYREF PUS1 IMP4 POLDIP3 LSM4 PARN RPL38 KHSRP ADAT3 SMG7 DCPS EXOSC2 CSNK1D PSMA3 FUS TRMT5 TRMT11 CSNK1E PAIP1 APOBEC3B RPS20 PRKCA A1CF IMP3 SNRNP40 HNRNPUL1 SLBP PSMB10 RPS29 MPHOSPH10 TRMT6 NUP88 RPL37A UTP18 RPL31 DDX39A PHF5A WDR4 SUPT5H TPR POLR2C HEATR1 RPS27 BOP1 RPL27A XPOT RPL19 RPL28 DHX9 PSMC4 CPSF4 UPF1 POLR2F ELAVL1 SF3A1 RTCB RPL9 PAN2 PSMD4 WDR77 WDR33 PPIE NUP160 GEMIN8 RPL36AL PSMF1 RPL27 SNRNP35 ZBTB8OS RPS8 RPL37 NUP214 QTRT1 WDR3 DDX42 CNOT11 TSEN54 ZMAT5 RBM28 RPS7 PSME3 SNRPA LCMT2 FTSJ3 RPL34 NUP133 EFTUD2 SNRPD2 PCF11 RPS16 RPS15A RPS26 SNRPE PSMC1 RPL8 UTP3 RPL35A NHP2 POLR2H RPS4X RPS27A LSM10 PSMD12 ERCC2 RPL30 PSMD2 UBA52 LSM7 UTP20 RPS23 SNRNP70 DUS2 RPL14 RPP38 PSMD13 PSMB4 POLR2A NUP188 ELAC2 BUD31 NUP85 UTP6 THOC2 NOL12 RPL39L MAGOH PPIH RPL41 SNRPC RPL23 IGF2BP3 GTF2H3 ERCC3 IGF2BP1 GEMIN5 RPL4 PPP2R1A PRPF38A PSMC5 RPL23A RPS13 GEMIN6 HNRNPF RBM17 UBC TSEN2 PABPN1 ANP32A FBL XRN2 SRSF9 DHX15 ZFP36L1 SUGP1 POP1 APOBEC3A PDCD11 RPS3A PSMB3 NUP98 SYMPK NUP107 CSTF1 NUP210 PSMC2 APOBEC1 HNRNPU CCAR1 PUS3 POM121C DNAJC8 THOC3 ZC3H11A SF3B5 GAR1 ETF1 APOBEC2 PDCD7 AAAS POLR2I RPS6 GNL3 RPL5 RPL26L1 NUP50 WDR43 PSMD1 SRSF6 RBMX HNRNPA2B1 SMG6 NOP58 PRPF4 HNRNPM HNRNPA1 HSPB1 MAPK11 SNRPB2 RPS24 NUP62 PSMB6 NOP10 up
## REACTOME_EUKARYOTIC_TRANSLATION_INITIATION 0.0013263 0.0088814 0.6522006 2.787283 0 112 EIF3B RPL13 EIF3I RPS21 RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 EIF2B5 RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 EIF3C RPL35 RPL29 RPL22 RPL13A RPS12 RPS28 EIF3D RPL3 RPLP2 RPS15 RPL11 FAU EIF2B3 RPL32 RPS14 RPS11 EIF4G1 RPL38 EIF3G RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 EIF3L RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 EIF5B EIF2B4 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A EIF2B2 RPL30 UBA52 RPS23 RPL14 RPL39L RPL41 RPL23 EIF4EBP1 RPL4 RPL23A RPS13 up
## GO_RIBOSOME_BIOGENESIS 0.0011779 0.0088814 0.5883896 2.781433 0 259 NOC2L MRPL20 NOB1 TBL3 NOM1 UTP14A BMS1 RPUSD1 PWP2 EXOSC6 MRTO4 GNL2 NIP7 EIF6 NOC4L TSR3 FAM207A ISG20L2 EXOSC10 PES1 MYBBP1A RPS21 NOP2 MRPS2 RPLP0P6 RPLP0 ERI3 NOP14 MTG2 RPS5 METTL16 WDR55 GEMIN4 MDN1 RRNAD1 NOL6 KRI1 DDX51 RPP25 RPL24 RRP9 RPUSD2 NSUN4 RPS2 NLE1 DHX37 NGDN DDX31 SART1 RSL1D1 RRN3 DDX27 RPL10A WDR18 RRP1 RPSA NOL9 RPL12 ERI1 RPL35 ERAL1 DDX56 EBNA1BP2 VCX LAS1L NOLC1 PELP1 NOP56 RPS28 RPL3 TRMT112 DDX49 AATF RPS15 DROSHA RPL11 RRP1B TFB2M NAT10 TSR1 MRPL11 NVL POP7 RRP7A EXOSC5 URB1 RPS14 IMP4 RPL38 GTPBP4 MALSU1 EXOSC2 DDX54 IMP3 RRS1 URB2 PPAN MPHOSPH10 NUP88 UTP18 ESF1 HEATR1 RPS27 BOP1 PIH1D1 MRPS7 ZNHIT6 RPL27 RPS8 RBFA WDR3 MRPS11 MPV17L2 NPM3 RPS7 DDX28 FTSJ3 RPS16 PAK1IP1 UTP3 RPL35A NHP2 ERCC2 SBDS UTP20 C1QBP RRP15 MRPL10 DHX30 RPL14 RPP38 GNL3L UTP6 GTPBP10 LYAR PA2G4 RPL23A NSUN5 RRP8 BRIX1 MRPL36 FBL XRN2 ZNF622 DDX10 PDCD11 HEATR3 NSUN3 up
## REACTOME_TRANSLATION 0.0011848 0.0088814 0.5881040 2.779400 0 262 AURKAIP1 MRPL20 EIF3B GSPT1 MRPS34 RPL13 MRPS18A TUFM EIF3I MRPL55 RPS21 EARS2 FARSB MRPS2 AIMP2 RPLP0 NARS2 MRPS15 RPS5 MRPL14 RPL24 MRPL49 RPS2 RPLP1 RPS3 EIF2B5 MRPL28 RPL36 MRPL48 DDOST DAP3 RPL10A RPL39 FARSA RPSA RPL18A RPL12 RPL18 MRPS26 EIF3C RPL35 MRPL17 ERAL1 RPL29 RPL22 RPL13A AARS2 RPS12 EEF1A2 RPS28 MTFMT EIF3D RPL3 TRMT112 RPLP2 RPS15 GADD45GIP1 RPL11 FAU EIF2B3 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 EIF4G1 EEF1D RPL38 MRPS35 EIF3G MRPL4 RPS20 MRPS33 MRPL12 MARS2 HARS2 RPS29 RPL37A RPL31 SSR2 RPS27 RPL27A RPL19 RPL28 MRPS7 TARS2 EEF2 MRPL23 RPL9 MRPL52 EIF3L MRPS6 SEC61G MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MRPS23 RPS7 RPL34 EIF5B MRPL21 EIF2B4 FARS2 RPS16 RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A SRPRB EIF2B2 RPL30 UBA52 RPS23 SRP68 MRPL10 CHCHD1 RPL14 MRPL27 PPA1 SARS2 SRP54 AIMP1 MRPS12 RPL39L PTCD3 RPL41 RPL23 YARS2 MRPS27 EIF4EBP1 TSFM RPL4 RPN2 OXA1L SEC61A1 RPL23A RPS13 EEF1B2 up
## LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 0.0012300 0.0088814 0.6056167 2.778920 0 202 SLC4A2 FADD MIPOL1 NUMA1 PPFIA1 ZNF3 INPPL1 LY6E TAF6 FASTK AKT1 CDK5 ABCF2 DPP3 JTB DHCR7 TFDP1 LAMTOR1 MTRR TSTA3 SDHA TMEM134 PRCC PI4KB BLCAP PIP5K1A CLCN2 CLPTM1L RMI2 EGFR YKT6 CCDC85C NDUFS6 CCDC127 PPP1R16A HDGF POLR2J BAZ1A ADAR ZNF74 GNB2 MAGEF1 ALKBH4 DDIT3 SLC12A7 ZSCAN21 KCNH2 NAT10 DAP SHC1 MRPL11 RAD23A METTL1 DVL3 EIF4G1 ARHGEF11 PDCD6 NKX2-1 PMVK USP21 USP13 STRN3 NUDT1 CCS HAX1 GCDH PYGO2 TMEM191A SSR2 RPS27 LPCAT1 PI4KA MET CCDC107 CCT5 MRPL23 COPS6 SEC61G JPH1 TRIM44 CDK4 CERS2 DUSP12 NUBP1 FIGNL1 NRDE2 IGSF8 AGO2 DENND4B KDM2A PAX9 PARD3 FAM131A B4GALT3 COCH MANBAL MCM7 POLR2H MED15 YY1 EAPP SRP54 PSMB4 CCT6A POGZ SRD5A1 MAF1 SLC39A1 CORO1B TPM3 TSFM S100A13 CRKL ILF2 FKBP9 MRPL36 FAM177A1 SIVA1 AP4S1 PPP1R3D DDX10 LANCL2 RTN4R TECPR2 ABCC5 NDUFS2 up
## chr7p22 0.0013812 0.0088814 0.6800156 2.778815 0 85 SUN1 ZDHHC4 GET4 EIF3B ZNF12 IQCE ADAP1 MAD1L1 PMS2 PMS2CL EIF2AK1 GPER1 USP42 INTS1 WIPI2 AIMP2 FBXL18 PSMG3 TNRC18 FAM220A TMEM184A SNX8 RNF216P1 C7orf50 BRAT1 RNF216 CHST12 AP5Z1 ZNF316 KDELR2 COX19 CARD11 DAGLB FOXK1 RAC1 RBAK C7orf26 MIR589 C1GALT1 ZNF890P PRKAR1B MICALL2 NUDT1 CYTH3 SLC29A4 ANKRD61 MAFK CCZ1B UNC93B2 TTYH3 GPR146 ALG1L5P GNA12 CCZ1 AMZ1 OR7E136P up
## GO_RIBOSOMAL_SUBUNIT 0.0012531 0.0088814 0.6147092 2.769705 0 172 MRPL20 MRPS34 RPL13 MRPS18A MRPL55 RPS21 MRPS2 RPLP0P6 RPLP0 MRPS15 RPS5 MRPL14 RPL24 NSUN4 MRPL49 RPS2 RPLP1 RPS3 NDUFAB1 MRPL28 RPL36 MRPL48 DAP3 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 MRPS26 RPL35 MRPL17 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 RPL38 MRPS35 MALSU1 MRPL4 RPS20 MRPS33 MRPL12 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 MRPS7 MRPL23 RPL9 MRPL52 MRPS6 MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MPV17L2 RPS7 RPL34 MRPL21 RPS16 RPS15A RPS26 FXR2 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 MRPL10 RPL14 MRPL27 C12orf65 MRPS12 RPL39L RPL41 RPL23 MRPS27 RPL4 RPL23A RPS13 MRPL36 MRPL34 RPS3A NSUN3 MRPS5 MRPS28 EIF2D up
## REACTOME_SELENOAMINO_ACID_METABOLISM 0.0013441 0.0088814 0.6529731 2.756930 0 102 RPL13 RPS21 AIMP2 CTH RPLP0 RPS5 RPL24 RPS2 RPLP1 RPS3 AHCY RPL36 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 RPL35 RPL29 SEPHS2 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 RPL11 FAU RPL32 RPS14 RPS11 RPL38 RPS20 RPS29 RPL37A RPL31 RPS27 RPL27A RPL19 RPL28 RPL9 RPL36AL RPL27 RPS8 RPL37 RPS7 RPL34 RPS16 EEFSEC RPS15A RPS26 RPL8 RPL35A RPS4X RPS27A RPL30 UBA52 RPS23 RPL14 AIMP1 RPL39L RPL41 RPL23 RPL4 RPL23A RPS13 up
## GO_RIBOSOME 0.0012151 0.0088814 0.5959649 2.755773 0 211 AURKAIP1 MRPL20 MRPS34 RPL13 MRPS18A MRPL55 RPS21 MRPS2 RPLP0P6 RPLP0 MRPS15 MTG2 RPS5 MRPL14 RPL24 RRBP1 NSUN4 MRPL49 RPS2 RPLP1 RPS3 NDUFAB1 MRPL28 RPL36 MRPL48 DAP3 RPL10A RPL39 RPSA RPL18A RPL12 RPL18 MRPS26 RPL35 PNPT1 MRPL17 SF1 RPL29 RPL22 RPL13A RPS12 RPS28 RPL3 RPLP2 RPS15 GADD45GIP1 RPL11 MRPL24 MRPL11 RPL32 MRPL41 MRPL37 RPS14 RPS11 RPL38 MRPS35 LARP1 DNAJC21 LARP4B MALSU1 MRPL4 RPS20 MRPS33 MRPL12 RPS29 RPL37A RPL31 BTF3 RPS27 RPL27A RPL19 RPL28 DHX9 MRPS7 EEF2 MRPL23 RPL9 MRPL52 MRPS6 MRPL33 MRPL51 RPL36AL RPL27 RPS8 RPL37 MRPS11 MRPL54 MPV17L2 MRPS23 RPS7 RPL34 MRPL21 RPS16 RPS15A RPS26 FXR2 RPL8 RPL35A HSPA14 RPS4X RPS27A RPL30 UBA52 RPS23 SRP68 MRPL10 CHCHD1 RPL14 MRPL27 C12orf65 MRPS12 RPL39L PTCD3 RPL41 EIF2AK2 APOD RPL23 MRPS27 APEX1 RPL4 RPL23A RPS13 RPS6KL1 MRPL36 MRPL34 RPS3A METTL17 NSUN3 MRPS5 MRPS28 EIF2D SERP1 EIF3H RPS6 RPL5 RPL26L1 up
## MORF_AATF 0.0012392 0.0088814 0.6012577 2.741552 0 191 DNAJC11 TRAPPC3 MFN2 SRRM1 RNPS1 MTOR TXLNA BMS1 TP53BP1 UBE2I GNL2 EIF6 TUFM EIF3I AIMP2 IDH3B SNRNP200 SRRT PSMD3 GTF2A2 XPO6 NUDC EIF2B5 THOP1 DHX38 SDHA DAP3 WDR18 KXD1 CLNS1A MTX1 SSRP1 FIBP PRPF8 NCL PREP DDX49 AATF RUVBL1 RUVBL2 ALDH4A1 HNRNPAB TRRAP NONO CLSTN1 ARFGAP2 SMARCC2 RAD23A SFSWAP IMMT NELFB SGTA HADH NAE1 PRKDC FUS RALY LRPPRC DDX39A POLR2C ATXN10 CYC1 TFAP4 PRKCSH PKMYT1 RTCB COPS6 COQ9 MMS19 ALG3 KHDRBS1 IDH3A CS SNRPA TCOF1 PHB PABPC4 SDR39U1 SSBP1 MLEC PIN1 UBE2L3 PSMD2 CUL1 LSM7 ACLY POLR2A NUP188 SART3 DRG1 DDB1 CCT2 BRD8 OXA1L ILF2 TERF2IP PABPN1 SAFB PSMB3 MCM2 KDM3B ADSL HNRNPU DNAJC8 SERP1 ETF1 POLR2I AFG3L2 CNPPD1 EIF3M HNRNPA2B1 HUWE1 NUP62 PSMB6 SERBP1 up
## GO_RIBOSOME_ASSEMBLY 0.0014306 0.0088814 0.7300998 2.737397 0 52 MRPL20 PWP2 MRTO4 NIP7 EIF6 NOP2 MRPS2 RPLP0P6 RPLP0 RPS5 MDN1 RPL24 NSUN4 NLE1 RPSA RPL12 ERAL1 VCX RPS28 RPL3 RPS15 RPL11 MRPL11 RRP7A RPS14 RPL38 RRS1 PPAN RPS27 BOP1 MRPS7 MRPS11 MPV17L2 DDX28 SBDS C1QBP DHX30 up
Clusters: 4 vs 1+2+3
fgsea_res <- fgsea_res_4v123
cond_nm <- 'Clusters: 4 vs 1+2+3'
fgsea_plot(fgsea_res$res_hm, pathways_title='Hallmark', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ----------------------------------------- ---------- ---------- ---------- --------- ------------- ----- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## HALLMARK_E2F_TARGETS 0.0034965 0.0053729 0.5524090 2.914792 0 191 CDKN2C UNG MCM2 MCM5 HMGB2 RANBP1 TIMELESS CDKN2A POLE4 TK1 GINS3 SSRP1 CENPM POLA2 TACC3 POLD1 ESPL1 DNMT1 POLE SLBP SPC24 PLK1 LIG1 HMGA1 NCAPD2 CHEK1 MCM7 KIF22 LMNB1 MCM3 MCM6 GINS4 KIF2C PTTG1 DONSON UBE2S KIF4A ASF1B MCM4 MXD3 RACGAP1 CDC20 DSCC1 NASP RNASEH2A NME1 MTHFD2 DDX39A RAN AURKB ATAD2 KIF18B MKI67 PA2G4 BIRC5 TUBG1 CDCA8 CDC25A WDR90 DEK DCTPP1 SNRPB SPAG5 MYBL2 STMN1 PPP1R8 POP7 CCNE1 CCNB2 TBRG4 EZH2 BRCA1 PNN SMC4 RAD51AP1 RRM2 DUT RPA2 UBE2T XRCC6 ILF3 BUB1B PLK4 GINS1 PRPS1 DIAPH3 HMMR DCLRE1B TRIP13 POLD2 NAA38 RPA1 STAG1 TOP2A CENPE PSMC3IP DLGAP5 PHF5A CDK4 AURKA SRSF1 TFRC MELK NOP56 CDKN1B up
## HALLMARK_MTORC1_SIGNALING 0.0034247 0.0053729 0.5176228 2.740950 0 190 GPI UNG MCM2 NUPR1 RPN1 NFKBIB DDIT4 ALDOA SLC9A3R1 GAPDH TOMM40 PSMD13 GMPS PLK1 PSMC4 PFKL SHMT2 ITGB2 TXNRD1 DDIT3 GLRX SLC2A1 P4HA1 ATP2A2 CORO1A SQSTM1 SLC1A5 MCM4 FKBP2 FDXR CTSC SDF2L1 AK4 ENO1 HK2 GSR PSMB5 ARPC5L MTHFD2 CCNF PDAP1 DDX39A PLOD2 CALR G6PD PPP1R15A FADS1 M6PR MLLT11 TUBA4A PRDX1 TUBG1 CDC25A BUB1 RDH11 STIP1 PHGDH LDHA HMBS TM7SF2 IMMT ACLY ABCF2 PGM1 SLC37A4 ME1 GGA2 PSAT1 IFI30 RRP9 SLC1A4 TRIB3 RRM2 CYP51A1 FADS2 YKT6 INSIG1 HSP90B1 HSPA9 PSMC2 SRD5A1 RPA1 GSK3B EGLN3 SLC7A5 AURKA GCLC PPIA TFRC CANX DHCR7 EIF2S2 GOT1 IGFBP5 NUP205 TES HSPD1 SERPINH1 SLA HSPA5 VLDLR CD9 PNP ELOVL6 up
## HALLMARK_DNA_REPAIR 0.0033003 0.0053729 0.5366322 2.710215 0 141 TARBP2 AAAS GTF3C5 POLE4 FEN1 TAF10 SUPT5H GMPR2 SSRP1 POLA2 NT5C POLD1 RFC5 POLR2H NME3 MRPL40 ADRM1 LIG1 NELFB USP11 POLD4 POLR2E POLR2F SAC3D1 DDB1 POLR2A GPX4 ALYREF DGCR8 GTF2F1 POLR2G POLR2I UMPS POLR2J NME4 RAD51 CLP1 ELL TAF1C NME1 DGUOK BRF2 SEC61A1 SNAPC5 COX17 EDF1 SF3A3 NCBP2 CDA ERCC1 APRT MPG DDB2 POLR3GL ERCC2 RFC4 HCLS1 VPS28 ZWINT PRIM1 TYMS TAF6 POLL SNAPC4 DUT GUK1 RPA2 up
## HALLMARK_MYC_TARGETS_V2 0.0026667 0.0053729 0.6307956 2.708519 0 57 UNG MCM5 DUSP2 PLK1 MRTO4 PUS1 LAS1L IMP4 WDR74 FARSA MCM4 NOC4L EXOSC5 HK2 TCOF1 NOP16 PHB GRWD1 PA2G4 PES1 DCTPP1 TBRG4 MYBBP1A RRP9 SRM PLK4 IPO4 RABEPK RRP12 PPAN SLC29A2 NOP2 NPM1 CDK4 NOP56 HSPD1 PPRC1 up
## HALLMARK_G2M_CHECKPOINT 0.0035461 0.0053729 0.5004091 2.632461 0 187 CDKN2C MCM2 MCM5 CDC45 INCENP POLA2 TACC3 ESPL1 POLE CHAF1A PLK1 HMGN2 TNPO2 PRC1 HMGA1 E2F2 POLQ CHEK1 SLC7A1 KIF22 ATF5 LMNB1 RAD54L MCM3 MCM6 PML SAP30 CHMP1A KPNB1 KIF2C PTTG1 UBE2S KIF4A TGFB1 NUMA1 CBX1 RACGAP1 CDC20 NASP CCNF TROAP PRMT5 DTYMK DDX39A CCNA2 TRAIP TLE3 SNRPD1 AURKB CDC6 MKI67 TPX2 BIRC5 CDC25A BUB1 ODF2 NCL E2F1 KIF11 NEK2 RAD23B GINS2 MYBL2 STMN1 MT2A SS18 EGF CCNB2 EZH2 PBK KIF15 HIRA KIF23 HOXC10 SMC4 UBE2C SMAD3 RPA2 CENPA FBXO5 ILF3 STIL PLK4 NUP50 HMMR STAG1 TOP2A CENPE NUSAP1 MARCKS CDK4 HSPA8 SMC2 SLC7A5 AURKA SRSF1 CDKN1B TTK KIF20B up
## HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 0.0025773 0.0053729 0.6390073 2.620706 0 46 ABCC1 CDKN2D ATOX1 PFKP LSP1 TXNRD1 GLRX GPX4 FES SOD1 GCLM SBNO2 GSR HMOX2 TXNRD2 G6PD JUNB MBP MPO PRDX1 ERCC2 NDUFS2 FTL STK25 EGLN2 up
## HALLMARK_MYC_TARGETS_V1 0.0034965 0.0053729 0.4610142 2.434005 0 189 FBL MCM2 MCM5 RANBP1 CDC45 MRPL23 CNBP PCBP1 HNRNPA1 PSMC4 RUVBL2 CCT7 RPLP0 MCM7 PSMA7 CYC1 MCM6 APEX1 PPM1G KPNB1 CAD SNRPA PSMD8 TRIM28 MCM4 SNRPD3 CDC20 PSMD3 NOP16 NME1 RRM1 PSMB3 CCNA2 RAN LSM7 SNRPD1 UBE2L3 SNRPD2 COX5A PHB PA2G4 EIF3D NCBP2 LDHA RFC4 DEK RAD23B CCT5 TUFM SET NDUFAB1 TYMS RRP9 RPS2 RPL22 RPL18 DUT SRM HDGF CSTF2 XRCC6 PSMD7 TXNL4A RPS3 RPS6 CDK2 UBA2 MRPL9 POLD2 TARDBP ILF2 NPM1 CDK4 SRSF1 POLE3 PPIA CANX NOP56 EIF2S2 HSP90AB1 NHP2 C1QBP RSL1D1 EIF4A1 PABPC1 HSPD1 SF3B3 PSMB2 PWP1 PRDX4 PCNA VDAC1 SNRPG MAD2L1 EIF3B SLC25A3 IMPDH2 STARD7 RPL14 BUB3 HDDC2 YWHAQ COPS5 CCT4 up
## HALLMARK_HYPOXIA 0.0033898 0.0053729 0.4617396 2.423390 0 180 TPST2 GPI FAM162A CHST3 DDIT4 HK1 ALDOA NDST2 DPYSL4 GAPDH GYS1 SCARB1 GALK1 PFKP PFKL PRDX5 DDIT3 GLRX SLC2A1 PPFIA4 P4HA1 S100A4 GRHPR MYH9 JMJD6 ALDOC ADM SAP30 SIAH2 SLC2A5 NAGK AK4 ENO1 HK2 JUN ILVBL XPNPEP1 PPP1R15A TGFBI STC2 VHL GAPDHS AMPD3 FBP1 B3GALT6 PIM1 LDHA P4HA2 PGM1 MT2A SLC37A4 MT1E HMOX1 PFKFB3 GCK TIPARP KIF5A VEGFA PGF FOXO3 GCNT2 GAA KDM3A IGFBP3 FOSL2 RRAGD PCK1 BCL2 CDKN1B HOXB9 GPC1 TES PLAUR HSPA5 CP COL5A1 VLDLR SDC3 TPBG TNFAIP3 BCAN PLIN2 STC1 CDKN1A ANKZF1 CHST2 up
## HALLMARK_GLYCOLYSIS 0.0034843 0.0053729 0.4582032 2.418945 0 188 ARTN FAM162A B3GAT3 PKM MPI DDIT4 ALDOA SLC16A3 DPYSL4 GYS1 GALK1 PLOD1 PFKP TALDO1 PSMC4 CLN6 PGAM1 GLRX PPFIA4 P4HA1 AKR1A1 SOD1 XYLT2 SAP30 POLR3K MED24 AGRN FKBP4 AK4 ENO1 HK2 NASP KIF20A GNPDA1 PLOD2 COPB2 G6PD TGFBI STC2 GAPDHS LHPP PC ALDH7A1 B4GALT7 SPAG4 SOX9 HAX1 CHPF2 B3GALT6 LDHA P4HA2 STMN1 RBCK1 SLC37A4 ME1 GALE GUSB ALG1 VEGFA MIOX SLC25A10 CENPA GPR87 PHKA2 PGLS B4GALT2 PRPS1 HMMR ABCB6 EXT2 IGFBP3 MDH1 TXN PAXIP1 CYB5A RRAGD EGLN3 AURKA GCLC PPIA GOT1 ECD GPC1 GFPT1 HSPA5 COL5A1 TPST1 VLDLR GMPPA SDC3 TPBG STC1 CHST12 ANKZF1 CHST2 CHST6 FBP2 GMPPB ISG20 up
## HALLMARK_P53_PATHWAY 0.0034247 0.0053729 0.4519126 2.392997 0 190 SLC3A2 HEXIM1 HRAS FAM162A NUPR1 TPD52L1 RAD9A CDKN2A RAP2B DDIT4 SERTAD3 ST14 CD82 ABHD4 CSRNP2 MXD4 DDIT3 TNFSF9 S100A4 DEF6 RNF19B IL1A IER5 TGFB1 BAX FDXR CTSF PROCR TRAFD1 RPS12 JUN SEC61A1 BAK1 PPP1R15A UPP1 RXRA WRAP73 DDB2 ACVR1B EPS8L2 JAG2 RHBDF2 RALGDS CCND3 PLXNB2 IFI30 CTSD TP63 SOCS1 SP1 HMOX1 MKNK2 RPL36 TRIB3 HDAC3 FBXW7 RPL18 DCXR APAF1 FOXO3 BLCAP CD81 VDR PLK3 VAMP8 APP ISCU ZFP36L1 TCN2 LDHB NINJ1 HBEGF HSPA4L SPHK1 NOTCH1 OSGIN1 MAPKAPK3 PRMT2 KRT17 CYFIP2 DGKA PHLDA3 DNTTIP2 SFN GADD45A ABCC5 ITGB4 STEAP3 CASP1 TCHH PCNA CEBPA TRAF4 CDKN1A EPHX1 CDK5R1 SLC7A11 RGS16 GPX2 MXD1 RRAD KLK8 S100A10 BTG1 GLS2 RRP8 PVT1 PPM1D ADA AEN up
## HALLMARK_OXIDATIVE_PHOSPHORYLATION 0.0034247 0.0053729 0.4564877 2.374167 0 175 GPI TIMM10 NDUFS7 MRPL11 MRPS11 NDUFB7 TIMM8B NDUFA1 COX5B ETFB NDUFS3 NDUFV1 TIMM50 ECH1 HTRA2 ECI1 RHOT2 UQCRC1 TCIRG1 MFN2 UQCR11 NDUFS8 TIMM13 POLR2F COX6B1 MRPS12 IDH3B GPX4 CYC1 PDHA1 COX4I1 NDUFC1 COX8A BAX ACADVL VDAC2 CPT1A NDUFB6 UQCRH COX17 COX5A ACAA1 HADHA CS NDUFB2 IDH2 NQO2 LDHA IMMT AFG3L2 ATP6V0C TOMM22 COX6A1 NDUFS6 SDHA MRPS22 MRPL34 NDUFAB1 PMPCA NDUFS2 NDUFA2 ECHS1 COX6C ATP6V1G1 ISCU LDHB NDUFA7 ATP6V1F HSPA9 AIFM1 COX7C OXA1L FDX1 MDH1 CYB5A SDHB ATP6V0B up
## HALLMARK_UV_RESPONSE_UP 0.0034364 0.0053729 0.4643534 2.341860 0 147 AP2S1 PPIF RPN1 PSMC3 FEN1 MRPL23 ALDOA KCNH2 SULT1A1 POLR2H BID STARD3 UROD CLTB ARRB2 MGAT1 SQSTM1 CDC34 PRKACA FKBP4 PDAP1 NPTX2 SHOX2 JUNB BAK1 SPR DNAJB1 SIGMAR1 KLHDC3 CEBPG BSG ACAA1 DLG4 TUBA4A CLCN2 MARK2 STIP1 RFC4 PARP2 WIZ MMP14 MAPK8IP2 CCND3 CCNE1 GAL CTSV STK25 HMOX1 IRF1 HTR7 LYN YKT6 DGAT1 ATP6V1F CDK2 DNAJA1 TGFBRAP1 TYRO3 POLE3 TFRC SLC6A12 NFKBIA up
## HALLMARK_INTERFERON_ALPHA_RESPONSE 0.0028986 0.0053729 0.4580263 2.164880 0 93 TRIM21 UBE2L6 PSME2 CSF1 PSME1 STAT2 RNF31 OGFR BATF2 BST2 MVB12A RIPK2 PARP9 TMEM140 PROCR TRAFD1 RTP4 IFI35 MOV10 IRF9 CD74 UBA7 PARP12 NUB1 IRF7 IFI30 LY6E IFITM3 LAP3 IRF1 IL4R PLSCR1 CMTR1 IFI27 IL15 USP18 GBP2 TRIM25 ADAR SP110 CASP1 LGALS3BP PSMB8 TRIM14 IRF2 up
## HALLMARK_ALLOGRAFT_REJECTION 0.0035461 0.0053729 0.4035972 2.123171 0 187 NOS2 IL10 CDKN2A CSF1 STAB1 SPI1 CSK CAPG ITGB2 APBB1 RIPK2 NCF4 PSMB10 IL27RA TGFB1 ELF4 NME1 CD4 CD40 EIF5A FCGR2B NLRP3 IFNGR2 EIF3D CCR2 ICOSLG CD1D GZMB CD74 ZAP70 FGR HCLS1 EIF4G3 LCK IRF7 CCND3 CD3D CCL19 EIF3A CD7 SOCS1 SIT1 MAP4K1 BRCA1 IL4R MRPL3 ITGAL IL12RB1 LYN CCL13 IL2RB PF4 IL15 STAT1 LCP2 HLA-G IL2RA PRKCG TRAF2 FASLG NPM1 AKT1 SRGN IL18 IL1B CCR5 PRF1 CD247 CCL4 GBP2 CXCR3 IKBKB CD8B CD3E TIMP1 IGSF6 MMP9 CCR1 NCK1 TNF IL2RG up
## HALLMARK_INTERFERON_GAMMA_RESPONSE 0.0034722 0.0053729 0.3889055 2.060000 0 194 TRIM21 UBE2L6 PSME2 PSME1 METTL7B PFKP STAT2 RNF31 OGFR BATF2 BST2 PML RIPK2 IL15RA IRF5 PSMB10 ITGB7 MTHFD2 TRAFD1 CD40 RTP4 IFI35 IL18BP UPP1 NUP93 NLRC5 CD274 CIITA IRF9 CD74 PIM1 PARP12 IRF7 MT2A RBCK1 IFI30 CSF2RB LY6E IFITM3 SOCS1 RNF213 LAP3 IL10RA IRF1 OAS3 IL4R TNFSF10 PLSCR1 IL2RB LYSMD2 VAMP8 CMTR1 IFI27 MVP IL15 STAT1 LCP2 C1R XCL1 HLA-G MYD88 USP18 CMKLR1 NFKBIA TNFAIP2 TRIM25 ADAR PSMB2 OAS2 SP110 VAMP5 APOL6 CASP1 STAT3 SECTM1 LGALS3BP PSMB8 TRIM14 TNFAIP3 PNP IRF2 ZNFX1 CDKN1A up
## HALLMARK_ADIPOGENESIS 0.0034364 0.0053729 0.3896162 2.047088 0 183 CDKN2C UBC SNCG PEX14 PEMT ESRRA ITGA7 NDUFB7 ALDOA ETFB NDUFS3 SCARB1 FAH SULT1A1 ECH1 UQCRC1 TALDO1 CHCHD10 ACADS PFKL CD151 VEGFB UQCR11 BAZ2A GPX4 UCK1 BCL2L13 CYC1 RETN SOD1 ESYT1 COX8A ALDH2 SLC1A5 RAB34 LIPE ARAF RMDN3 STAT5A RREB1 CS YWHAG PREB BCL6 IMMT ACLY COX6A1 PGM1 APOE ME1 NDUFAB1 RIOK3 ABCB8 PFKFB3 ECHS1 ANGPT1 AGPAT3 APLP2 ELMOD3 SLC25A10 DHRS7 COQ5 DGAT1 EPHX2 SLC27A1 C3 AIFM1 DDT up
## HALLMARK_MYOGENESIS 0.0034247 0.0053729 0.3824583 2.025218 0 190 AKT2 PFKM CAMK2B MYL6B ACTC1 TPD52L1 NOS1 ITGA7 KCNH2 ATP2A1 SIRT2 FOXO4 LSP1 MYOG PICK1 SVIL PPFIA4 MYH9 PDLIM7 MAPRE3 SH2B1 TPM2 HDAC5 HRC TNNT1 TGFB1 TNNI2 AGRN COX7A1 SPTAN1 PVALB STC2 TPM3 BIN1 RYR1 PC GSN MYOZ1 FLII CHRNB1 TEAD4 PLXNB2 MYLPF ITGB5 ACTN3 MB ACTA1 APP GAA FABP3 CASQ1 CKM TSC2 HBEGF SPHK1 NOTCH1 IGFBP3 OCEL1 EPHB3 SYNGR2 COX6A2 SORBS3 COL6A2 MYO1C BAG1 SPEG CRAT LPIN1 ITGB4 PDE4DIP CHRNG PRNP KIFC3 up
## HALLMARK_MITOTIC_SPINDLE 0.0034722 0.0053729 0.3748881 1.991468 0 195 RHOF INCENP SHROOM2 CLIP1 ACTN4 ESPL1 SUN2 PXN MAP3K11 RHOT2 PLK1 PRC1 SAC3D1 KPTN KIF22 LMNB1 MYH9 ARHGDIA TUBGCP2 MAP1S KIF2C CEP250 TAOK2 KIF4A CAPZB PIF1 NUMA1 RACGAP1 MYO9B PREX1 KNTC1 TRIO SPTAN1 VCL FSCN1 BIN1 TPX2 LLGL1 KIF3C TUBA4A BIRC5 CDC42EP4 GSN BUB1 DYNLL2 TIAM1 ABR ARF6 KIF11 NEK2 ARFIP2 ARL8A CCNB2 MARK4 KIF15 KATNB1 WASF2 KIF23 CKAP5 SMC4 KIF1B CEP72 FBXO5 CDK5RAP2 ATG4B PLEKHG2 MID1IP1 TBCD PCNT BCR CSNK1D TOP2A CENPE NUSAP1 MARCKS DLGAP5 ANLN DOCK2 AURKA CTTN BCAR1 TTK KIF20B up
## HALLMARK_IL6_JAK_STAT3_SIGNALING 0.0028736 0.0053729 0.4294476 1.989647 0 82 IL17RA CSF1 CD14 STAT2 TNFRSF1B IL15RA TNFRSF1A TGFB1 TYK2 GRB2 JUN LTBR CSF2 BAK1 PIK3R5 IFNGR2 ACVR1B HAX1 IRF9 IL10RB EBI3 PIM1 CSF2RB SOCS1 HMOX1 IRF1 TNFRSF12A IL4R INHBE IL12RB1 PF4 STAT1 IL2RA MYD88 IL1B PTPN11 STAT3 CCR1 CD9 TNF IL2RG up
## HALLMARK_APOPTOSIS 0.0033670 0.0053729 0.3874400 1.978879 0 155 AIFM3 HMGB2 GNA15 CD14 RHOT2 NEFH BID DDIT3 GPX1 GPX4 SOD1 TSPO PLCB2 IL1A SQSTM1 BAX HSPB1 FDXR VDAC2 GSR IGF2R JUN MADD SPTAN1 MGMT RELA CREBBP KRT18 BCL2L2 GSN RARA PPP2R5B DFFA CASP2 IFITM3 HMOX1 IRF1 BRCA1 TNFRSF12A CASP9 TNFSF10 DIABLO APP CDK2 SMAD7 FASLG DNAJA1 TOP2A IL18 IL1B PRF1 ADD1 CDKN1B GADD45A BMF TIMP1 BCL2L1 CASP1 PAK1 TNF PMAIP1 CDKN1A DPYD up
## HALLMARK_APICAL_JUNCTION 0.0034965 0.0053729 0.3733880 1.971367 0 189 AKT2 RHOF HRAS ACTC1 VASP ZYX KCNH2 SHROOM2 ACTN4 CD276 STX4 PFN1 MAP4K2 MYH9 ACTB GTF2F1 RAC2 MDK TAOK2 NLGN3 GAMT SYMPK SRC GNAI2 VCL TGFBI FSCN1 FLNC CD274 YWHAH TUBG1 AMH SYK TRAF1 MSN TMEM8B TSPAN4 BMP1 INPPL1 CLDN11 MADCAM1 NRXN2 LAMA3 SIRPA NFASC MAPK13 PARD6G ACTN3 NLGN2 ACTA1 CD209 DMP1 RRAS MAPK11 ADAM9 INSIG1 GRB7 EVL ACTN1 TRO PDZD3 CDH3 LAMB3 VAV2 LAYN CDSN SORBS3 SPEG CRAT IKBKG ITGB4 ITGA3 CERCAM MVD SDC3 MMP9 CAP1 up
## HALLMARK_PEROXISOME 0.0030581 0.0053729 0.3990710 1.920164 0 103 CEL ABCB9 HRAS ALDH1A1 PEX14 CNBP ECH1 CACNA1B CLN6 PRDX5 ITGB1BP1 SLC25A19 SOD1 TSPO FIS1 FABP6 PEX5 DHRS3 FADS1 ACAA1 DLG4 PRDX1 YWHAH ERCC1 IDH2 RDH11 GSTK1 HSD3B7 CTBP1 ACSL4 up
## HALLMARK_APICAL_SURFACE 0.0026042 0.0053729 0.4642827 1.841740 0 42 LYPD3 FLOT2 SHROOM2 CROCC RHCG HSPB1 AFAP1L2 GHRL GATA3 TMEM8B BRCA1 LYN IL2RB APP GAS1 GSTM3 MDGA1 DCBLD2 PLAUR EFNA5 IL2RG SLC2A4 SULF2 up
## HALLMARK_UNFOLDED_PROTEIN_RESPONSE 0.0030581 0.0053729 0.3798081 1.827479 0 103 DCTN1 EIF4EBP1 DDIT4 BANF1 CEBPB EIF4G1 IMP3 KHSRP CXXC1 TATDN2 EXOSC2 LSM4 ZBTB17 EXOSC5 MTHFD2 CALR PDIA5 ARFGAP1 EIF4A3 STC2 CEBPG SRPRB PREB NOP14 PSAT1 ATF4 POP4 BAG3 FUS RRP9 SLC1A4 VEGFA LSM1 PDIA6 HSP90B1 EEF2 HSPA9 NFYB CHAC1 NPM1 RPS14 EIF2AK3 EDC4 SLC7A5 NOP56 NHP2 EIF4A1 up
## HALLMARK_TNFA_SIGNALING_VIA_NFKB 0.0034722 0.0053729 0.3437895 1.826268 0 195 CSF1 FJX1 CEBPB DUSP2 G0S2 NFKBIE TNIP1 TNFSF9 TNIP2 RIPK2 RNF19B ZC3H12A IL15RA IL1A IER5 SQSTM1 PHLDA2 IL23A JUN CSF2 STAT5A JUNB TRIP10 PPP1R15A CCL20 IFNGR2 RELA ICOSLG PLEK TRAF1 NFKB2 BCL6 SNN ZBTB10 RELB EHD1 TNC B4GALT5 PFKFB3 IRF1 TIPARP VEGFA SMAD3 PANX1 TNFRSF9 FOSL1 NINJ1 HBEGF SPHK1 BCL2A1 FOSL2 LAMB3 IL18 MARCKS MSC IL1B PLAU CCL4 NFKBIA SPSB1 TNFAIP2 GADD45A PLAUR up
## HALLMARK_COMPLEMENT 0.0035088 0.0053729 0.3407144 1.801256 0 193 SIRT6 LTF S100A9 CEBPB ATOX1 CALM3 FCN1 STX4 RHOG PFN1 PPP4C PRSS36 ITGAM C1QC MT3 PRDM4 CTSC C1QA MSRB1 SRC GNAI2 GRB2 XPNPEP1 PHEX PIK3R5 KCNIP2 RCE1 CDA PLEK GZMB SH2B3 CTSL PIM1 APOBEC3F GATA3 MMP14 GNGT2 LCK IRF7 EHD1 CTSB S100A13 ME1 GNB2 LRP1 KLK1 CTSD CTSV LAP3 DGKG APOBEC3G IRF1 GP1BA SPOCK2 CASP9 PLSCR1 LYN ADAM9 APOC1 FCER1G LCP2 C1R C3 up
## HALLMARK_PI3K_AKT_MTOR_SIGNALING 0.0030581 0.0053729 0.3736408 1.797804 0 103 HRAS AP2M1 PIN1 NFKBIB CFL1 PAK4 AKT1S1 PFN1 DDIT3 PPP1CA STAT2 SLC2A1 ECSIT ARHGDIA TNFRSF1A SQSTM1 GRB2 CALR RPS6KA1 RPTOR TIAM1 E2F1 LCK FGF22 ATF1 MKNK2 TRIB3 HSP90B1 TSC2 CDK2 MAPKAP1 MKNK1 TRAF2 MYD88 FASLG AKT1 GSK3B CAB39 CDK4 GNGT1 PTPN11 CDKN1B up
## HALLMARK_XENOBIOTIC_METABOLISM 0.0034843 0.0053729 0.3347623 1.767276 0 188 CRP MPP2 BLVRB PEMT NPC1 GSTA3 FAH ABCC2 ECH1 DHPS GSS SPINT2 ACP2 SHMT2 COMT LONP1 GSTM4 CNDP2 PGD PSMB10 ATP2A2 SERTAD1 TNFRSF1A ALDH2 SLC1A5 PPARD PINK1 GSR GABARAPL1 ADH5 CYP2S1 CSAD GSTO1 UPP1 DHRS1 MAN1A1 PC CDA FBP1 MT2A APOE HMOX1 DCXR AHCY DHRS7 CCL25 ADH1C GCNT2 ASL NINJ1 SLC46A3 DDT SLC12A4 CYB5A NDRG2 ADH7 GCLC SLC6A12 ESR1 CYFIP2 BCAR1 SERPINA6 MTHFD1 up
## HALLMARK_INFLAMMATORY_RESPONSE 0.0035088 0.0053729 0.3331044 1.761024 0 193 IL10 CSF1 STAB1 CCL17 GNA15 CD82 CD14 ADRM1 RHOG NOD2 TNFSF9 OSM SLC7A1 ATP2C1 BST2 TNFRSF1B RIPK2 ADM IL15RA IL1A EMP3 ATP2A2 MARCO BEST1 P2RX4 KCNMB2 PVR CD40 RTP4 NLRP3 PIK3R5 CCL20 IFNGR2 RELA ICOSLG PTAFR ACVR1B EBI3 P2RX7 MMP14 LCK IRF7 LY6E IL10RA IRF1 GP1BA IL4R SCARF1 TNFSF10 LYN KIF1B IL2RB GPR132 TNFRSF9 IL15 MEFV LCP2 HPN HBEGF SPHK1 ITGA5 SEMA4D IL18 IL1B CMKLR1 up
## HALLMARK_ESTROGEN_RESPONSE_LATE 0.0035088 0.0053729 0.3280773 1.734447 0 193 RBBP8 PPIF BLVRB TPD52L1 LTF S100A9 SLC9A3R1 ETFB ST14 SCARB1 DUSP2 CPE LSR FAM102A SIAH2 AMFR MDK DLG5 ITPK1 FKBP4 CDC20 RNASEH2A KIF20A NAB2 HOMER2 KRT19 PKP3 TRIM29 CDC6 IDH2 RAPGEFL1 SLC26A2 TIAM1 METTL3 GINS2 DNAJC1 ST6GALNAC2 GALE GAL NCOR2 IGSF1 MAPK13 SERPINA5 SLC1A4 ANXA9 NXT1 COX6C DCXR CYP4F11 STIL PLK4 CHST8 HSPA4L PLAC1 SLC2A8 TOP2A PLXNB1 SCNN1A ASS1 BATF SLC7A5 up
fgsea_plot(fgsea_res$res_c1, pathways_title='C1 positional genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## --------- ---------- ---------- ----------- ---------- ------------- ----- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## chr1q24 0.0015504 0.0102949 -0.5901897 -2.474969 0 82 CCDC181 BLZF1 VAMP4 SLC19A2 TADA1 KIFAP3 SUCO RNU6-1310P SCYL3 SFT2D2 MIR214 PIGC DUTP6 MGST3 DNM3 DNM3OS AIMP1P2 MYOC GORAB TMCO1 MRPS10P1 MPZL1 MPC2 LRRC52 ATP1B1 MROH9 RPL29P7 FMO2 NME7 TIPRL ADCY10 RNU6-157P SELP SUMO1P2 FMO3 LINC00970 RN7SL269P RN7SL333P DNM3-IT1 FMO4 MIR1295A FMO6P C1orf112 C1orf105 POU2F1 PRRC2C MAEL SELE ALDH9A1 METTL18 MIR1255B2 POGK DCAF6 down
## chr13q32 0.0015723 0.0102949 -0.6062271 -2.458863 0 67 PCCA-AS1 MBNL2 UGGT2 DOCK9-AS1 PCCA TM9SF2 RNU6-83P TGDS RPL7L1P12 TMTC4 FARP1-AS1 SOX21 DCT ABCC4 DOCK9 MTCYBP3 DNAJC3 CLYBL-AS1 MTND5P2 RN7SKP8 FARP1 GPR18 MTND6P18 SOX21-AS1 GPR180 RPL15P18 IPO5 RNY3P8 RNU6-62P CLYBL-AS2 MIR3170 LINC00391 LINC00449 NALCN-AS1 ZIC5 FTLP8 CLYBL ASNSP3 ZIC2 down
## chr5q12 0.0015898 0.0102949 -0.6514663 -2.376353 0 39 ERCC8 LRRC70 PDE4D TRAPPC13 MAST4-IT1 RNF180 RGS7BP IPO11 DIMT1 SREK1IP1 PPWD1 RNU6-540P SREK1 MAST4 PART1 MIR582 SMIM15 ADAMTS6 TRIM23 MAST4-AS1 RPEP1 down
## chr2q33 0.0015015 0.0102949 -0.5370365 -2.356107 0 105 CYP20A1 CARF TYW5 NBEAL1 CREB1 MOB4 TRAK2 ORC2 STRADB FAM126B FASTKD2 SF3B1 INO80D PGAP1 RPL7P14 RFTN2 CCNYL1 ABI2 GPR1 ALS2 CFLAR-AS1 ICA1L CPO C2orf69 RNU7-45P COQ10B AOX3P MIR2355 BMPR2 KLF7-IT1 RNU6-762P MPP4 PSMA2P3 RAPH1 GTF3C3 HNRNPA3P15 MTND4P29 NDUFS1 PPIL3 BOLL METTL21A ANKRD44-IT1 FAM117B RNU6-1206P PARD3B AOX1 MRPL50P2 CLK1 DAZAP2P1 SNORD51 SNORD70 MTND5P31 SNORD11B C2orf66 CDK15 BZW1 MTND5P25 MARS2 KLF7 CASP10 KCTD18 ZDBF2 CFLAR SNORD11 SATB2 SEPHS1P6 WDR12 TMEM237 FZD7 down
## chr2q31 0.0015060 0.0102949 -0.5367167 -2.312739 0 94 DCAF17 SESTD1 KLHL41 LRP2 PLEKHA3 CWC22 KLHL23 SCRN3 PRKRA ATF2 FKBP7 UBR3 CCDC173 OSBPL6 TTN-AS1 CYBRD1 ZNF385B GAD1 TTC30A PHOSPHO2 RN7SL65P MIR3128 NFE2L2 ABCB11 PPIG CHN1 ERICH2 CHRNA1 AGPS HAT1 SLC25A12 SP5 TTN HNRNPA3 RAPGEF4 HOXD1 TTC30B RNU6-182P FASTKD1 CERKL DYNC1I2 GPR155 RBM45 ITGA6 TLK1 CIR1 RPS6P2 OLA1 down
## chr13q14 0.0014286 0.0102949 -0.4985302 -2.310323 0 151 ALG11 TPTE2P5 SUGT1 PCNPP5 FNDC3A RB1 KPNA3 NEK5 CAB39L LRRC63 RNU6-57P PHF11 FAM216B TRIM13 ESD COG3 SUGT1P3 CTAGE3P TPT1 UTP14C KCTD4 VPS36 NAA16 COG6 KCNRG CCDC122 CPB2 CDADC1 SNRPGP14 MTRF1 ENOX1-AS2 RCBTB1 RNY1P6 ITM2B INTS6 INTS6-AS1 SUCLA2 DHRS12 CPB2-AS1 RAD17P2 RNY3P2 RN7SL413P RPS4XP16 RNA5SP28 PCDH8 GUCY1B2 RNA5SP29 SUCLA2-AS1 FABP5P2 ATP7B RNU6-60P RNY4P24 CCDC70 SLC25A30 SPRYD7 DNAJC15 ENOX1-AS1 DLEU2 MED4-AS1 AKAP11 OLFM4 LINC00330 MRPS31P5 GPALPP1 RNASEH2B ELF1 MED4 RN7SL515P THSD1 SETDB2 LINC00562 LPAR6 SMARCE1P5 down
## chr1p31 0.0014663 0.0102949 -0.5091096 -2.282361 0 120 ZRANB2-AS2 MIR186 FPGT ANGPTL3 RN7SL370P TM2D1 MIR3671 LEPR WDR78 FPGT-TNNI3K ATG4C RNU6-1176P ZRANB2 KANK4 SRSF11 LRRC40 NEGR1 EFCAB7 ALG6 TCTEX1D1 ARL5AP3 PTGFR RNU6-387P ITGB3BP RNU6-414P LRRIQ3 LEPROT RNA5SP20 MIR4794 PIGK PTGER3 TNNI3K DOCK7 GNG12-AS1 MIR1262 RAVER2 IL23R ZRANB2-AS1 RNA5SP23 NFIA MIR3117 RNU4-88P TTLL7 CRYZ TTLL7-IT1 UBE2U SLC2A3P2 RNU6-809P MED28P8 DLEU2L L1TD1 GNG12 MIER1 TYW3 RNU6-1102P GIPC2 PRKACB RNU6-503P SGIP1 DIRAS3 GDI2P2 CTH HNRNPA3P14 CACHD1 ANKRD13C PSAT1P3 RABGGTB RN7SL488P NEXN FUBP1 USP33 RNU7-80P ST13P20 RNU7-123P IFI44 WLS CTBP2P8 PDE4B LHX8 RN7SL180P LRRC53 MIR101-1 SAMD13 RNFT1P2 ST6GALNAC5 down
## chr3p14 0.0015480 0.0102949 -0.5407748 -2.276581 0 83 MAGI1-IT1 RPL17P17 PRDX3P4 SNTN PRICKLE2-AS3 CCDC66 C3orf14 MAGI1-AS1 DNAH12 PRICKLE2-AS2 RNF7P1 FAM3D APPL1 RNU6-1181P C3orf49 ADAMTS9-AS1 ILF2P1 LMOD3 MIR3136 RNU6-787P FAM107A UBA3 PRICKLE2 ARF4 MAGI1 FHIT LINC00994 EOGT ASB14 ADAMTS9-AS2 RPL10AP6 PSMD6-AS2 PTPRG-AS1 NDUFB4P1 RBM43P1 TMF1 PSMD6 RNU2-10P RPP14 ARHGEF3-AS1 DENND6A RNU6-108P FRMD4B PDHB FLNB-AS1 PPIAP16 ARHGEF3 SYNPR down
## chr2q32 0.0015949 0.0102949 -0.5564040 -2.227891 0 63 RPL21P32 ORMDL1 ANKAR RN7SL820P TFPI TMEFF2 RNU6-1045P PMS1 RNU6-915P NUP35 DUSP19 ST13P2 OSGEPL1 WDR75 DNAH7 HIBCH HECW2 CALCRL ASNSD1 MIR561 RN7SKP42 NCKAP1 MED28P3 FSIP2 MIR1245A GULP1 MYO1B C2orf88 OSGEPL1-AS1 SLC39A10 NABP1 RPL23AP35 RN7SKP179 MSTN PDE1A DNAJC10 DIRC1 MFSD6 DPRXP1 ZC3H15 down
## chr15q21 0.0014837 0.0102949 -0.5031215 -2.201508 0 102 EID1 POLR2M ARPP19 ZNF280D DTWD1 TRPM7 RNA5SP395 MIR4712 COPS2 AP4E1 SECISBP2L PYGO1 FAM227B CNOT6LP1 HNRNPA3P11 PIGB SPG11 SEMA6D CCPG1 PRTG SLC24A5 TCF12 FGF7 USP8 EEF1A1P22 SLC28A2 RNU6-844P MNS1 EIF3J RN7SL577P GCOM1 CGNL1 DUOX1 MIR628 RN7SKP139 UNC13C RPSAP55 MYO5C RAB27A MIR1266 SHC4 SLC27A2 DUOXA2 BLOC1S6 TEX9 NEDD4 SPPL2A NDUFAF4P1 DUOXA1 TMOD2 SLC12A1 SCG3 DCAF13P3 SLC30A4 TMOD3 FAM214A RSL24D1 EEF1B2P1 RFX7 down
## chr7p21 0.0015699 0.0102949 -0.5863157 -2.199042 0 45 TMEM106B AGR2 ETV1 AGR3 SOSTDC1 SNX13 ICA1 SCIN RNU6-534P TSPAN13 RAD17P1 COL28A1 DGKB MACC1-AS1 NDUFA4 NPM1P11 MIOS RPL36AP29 ANKMY2 AHR MACC1 TWISTNB MIR3146 ABCB5 NPM1P13 GLCCI1 RN7SKP266 PHF14 NXPH1 MEOX2 down
## chr13q33 0.0016103 0.0102949 -0.5902685 -2.113744 0 35 FGF14 ABHD13 LIG4 RPL39P29 MYO16-AS1 LIPT1P1 TPP2 FGF14-IT1 METTL21C RNA5SP39 MIR4705 HMGB3P7 TEX30 BIVM NALCN MIR1267 FAM155A METTL21EP MYO16 FGF14-AS1 down
## chr13q22 0.0016447 0.0102949 -0.6250830 -2.111337 0 26 LMO7 FAM204CP RNU6-79P RNY3P7 SCEL SCEL-AS1 RPL21P108 FBXL3 EDNRB CLN5 KLF12 SLAIN1 KLF5 EDNRB-AS1 MYCBP2-AS2 UCHL3 MYCBP2 down
## chr5q11 0.0015699 0.0102949 -0.5602965 -2.101454 0 45 SLC38A9 ARL15 MIR581 RNU6-272P ITGA1 NDUFB4P2 RN7SL801P EMB ITGA2 IL6ST MIR5687 GPBP1 MIER3 DHX29 CDC20B HSPB3 MOCS2 RPL17P22 PARP8 DDX4 SETD9 LINC01033 RNF138P1 HNRNPH1P3 ANKRD55 AK4P2 down
## chr5p13 0.0015528 0.0102949 -0.4921690 -2.069386 0 84 RANBP3L C1QTNF3 C6 C5orf51 RNU6-378P RNU6-1190P RPS4XP6 RICTOR RNU6-484P RNU6-1079P OFD1P17 ZFR LIFR RNU7-75P RN7SL37P CAPSL CDH6 LMBRD2 RNU7-161P MIR579 PDZD2 NPR3 PLCXD3 GHR RAI14 SPEF2 MTMR12 AIG1P1 GDNF GDNF-AS1 RAD1 C9 TTC33 FBXO4 PRKAA1 AGXT2 MROH2B RNU6-358P RPL5P14 DAB2 NIPBL MTHFD2P6 SERBP1P6 NUP155 TTC23L MIR580 EGFLAM-AS2 LSP1P3 SLC1A3 LIFR-AS1 down
## chr13q31 0.0015924 0.0102949 -0.5629075 -2.035969 0 36 NDFIP2 GPC5 RBM26 GPC5-AS2 FABP5P4 RNA5SP33 GPC5-IT1 BCAS2P3 MIR17HG NIPA2P5 GPC6-AS2 RBM26-AS1 LINC01068 SPRY2 SP3P down
## chr1q41 0.0015773 0.0102949 -0.5290111 -2.032401 0 49 RNU6-403P BROX LYPLAL1 CAPN8 DISP1 TLR5 NDUFB1P2 SNRPEP10 MIR215 TAF1A AIDA MIR194-1 SNORA36B RAB3GAP2 RRP15 MARC1 SPATA17 RNU6ATAC35P MARC2 RN7SL464P GPATCH2 RPS15AP12 MIA3 RIMKLBP2 TGFB2 down
## chr19p12 0.0015924 0.0102949 -0.5597662 -2.024608 0 36 VN1R83P VN1R81P VN1R82P ZNF431 ZNF708 ZNF728 ZNF493 ZNF430 ZNF429 ZNF91 ZNF681 ZNF714 VN1R80P ZNF257 ZNF208 RPL7AP10 ZNF209P down
## chr13q13 0.0015601 0.0102949 -0.5369918 -2.023578 0 46 FREM2 SUPT20H STOML3 UFM1 KL N4BP2L2 FREM2-AS1 PDS5B LINC00457 SERTM1 SCAND3P1 NBEA N4BP2L1 ALG5 RNY1P4 MAB21L1 FRY CCDC169 SMAD9 RXFP2 EXOSC8 FRY-AS1 down
## chr9q31 0.0015625 0.0102949 -0.4931572 -1.980382 0 61 STX17 ALDOB FKTN MRPL50 FYTTD1P1 DNAJC25 FSD1L C9orf152 ERP44 BAAT TXNDC8 FRRS1L MIR4668 ZNF462 OR13D1 RNU6-432P TMEM245 NIPSNAP3A TEX10 PTPN3 RNU6-1013P INVS CTNNAL1 ZNF483 OR13D3P RNA5SP294 SLC44A1 UGCG LRRC37A5P NR4A3 MUSK EPB41L4B YBX1P6 NIPSNAP3B OR2K2 NANOGP5 ZNF189 ACTL7A RNU6-1039P MIR32 ACTL7B SVEP1 down
## chr2p16 0.0015504 0.0102949 -0.5058901 -1.960734 0 51 PAPOLG CLHC1 PNPT1 RNA5SP93 FSHR RNU4-51P NRXN1 RNU4-49P RNU6-282P FBXO11 STON1-GTF2A1L MIR3682 GTF2A1L STON1 PPP1R21 RNA5SP95 C2orf73 FOXN2 CTBP2P5 ERLEC1 LHCGR FANCL RNU7-172P EML6 NONOP2 PSME4 GPR75 EFEMP1 RPL36AP15 down
## chr6q14 0.0015773 0.0102949 -0.5077443 -1.950697 0 49 IMPG1 RN7SKP163 IBTK FILIP1 RNU6-155P SNX14 RNU1-34P SH3BGRL2 TMEM30A MYO6 HMGB1P39 BCKDHB RPL17P25 RNU6-1016P LAP3P1 SENP6 IRAK1BP1 SYNCRIP PHIP RNA5SP210 PGM3 CYB5R4 PKMP3 RNU6-130P MIR4463 LCA5 UBE3D MRAP2 HMGN3 NT5E ZNF292 down
## chr10p13 0.0015974 0.0102949 -0.5242357 -1.933460 0 41 TRDMT1 RNU6ATAC39P VIM-AS1 NMT2 CUBN PRPF18 BTBD7P1 PHYH RNU6-6P SNRPGP5 OLAH PTER MIR4480 PPIAP30 MIR548Q BEND7 ITGA8 HSPA14 MEIG1 FAM107B RNA5SP300 RSU1 CCDC3 SUV39H2 CAMK1D down
## chr3p26 0.0016340 0.0102949 -0.5609194 -1.933015 0 27 CHL1-AS1 CNTN4 CNTN6 CHL1 CNTN4-AS2 CRBN RPS8P6 RNU6-1194P TRNT1 CNTN4-AS1 CHL1-AS2 MRPS10P2 PNPT1P1 EGOT ITPR1 IL5RA down
## chrYq11 0.0016420 0.0102949 -0.5507047 -1.928642 0 31 CD24P4 RNU6-255P PSMA6P1 ARSDP1 FAM224B DPPA2P1 GYG2P1 TAB3P1 AGKP1 NEFLP1 ARSFP1 ZNF839P1 TMSB4Y CDY4P NLGN4Y-AS1 TTTY25P RN7SL702P RBMY2FP CASKP1 NLGN4Y USP9Y TMEM167AP1 DDX3Y TTTY10 UTY FAM8A4P TTTY14 down
## chr2q34 0.0016694 0.0102949 -0.5898968 -1.926735 0 23 ERBB4 MIR548F2 MYL1 RNA5SP118 LANCL1 ACADL CPS1 KANSL1L RPL5P8 VWC2L IKZF2 MTND2P23 PIKFYVE SPAG16 PKP4P1 down
## chr4q21 0.0015504 0.0102949 -0.4576817 -1.919295 0 82 HNRNPDL THAP9 RN7SKP96 RCHY1 USO1 MAPK10 SLC25A14P1 LINC01088 RNU6-469P FAM47E THAP6 TMEM150C PAQR3 SEC31A MRPL1 RPL3P13 MIR4451 NPM1P41 SNX5P1 RPL7AP26 PLAC8 NAA11 FRAS1 MIR4450 SHROOM3 SCARB2 CCDC158 CDKL2 WDFY3 BMP3 MIR575 PTPN13 NUP54 PPEF2 THAP9-AS1 ARHGAP24 RASGEF1B CNOT6L HELQ CXCL11 SDAD1 SERBP1P5 TECRP1 RN7SL552P CDS1 HNRNPD down
## chr2p22 0.0016077 0.0102949 -0.4779467 -1.917011 0 64 RNU6-198P MAP4K3 SLC30A6 SOS1 SOS1-IT1 FEZ2 BIRC6-AS1 CYP1B1-AS1 HEATR5B CDKL4 ARHGEF33 THUMPD2 BIRC6 CRIM1 RNU6-951P SPAST EIF2AK2 RMDN2 RNU6-647P RNU6-851P HNRNPA1P61 ATL2 RNA5SP91 MIR558 NDUFAF7 GPATCH11 PRKD3 CEBPZ YIPF4 STRN VIT down
## chr18p11 0.0015152 0.0102949 -0.4448994 -1.912466 0 93 LINC00667 NAPG DLGAP1-AS5 USP14 METTL4 RNU5F-3P THOC1 VAPA DLGAP1 L3MBTL4 PPP4R1 ANKRD12 RNA5SP450 ANKRD20A5P RNU2-27P CLUL1 DLGAP1-AS4 GAPDHP66 CEP76 NDUFV2 DLGAP1-AS3 KRT18P8 SPIRE1 FEM1AP2 RNA5SP449 MYL12A LPIN2 PTPRM RNMT RNU6-831P YES1 RNU6-316P PSMG2 ARHGAP28 FAM210A ROCK1P1 TWSG1 APCDD1 ZNF519 CYP4F35P GNAL RHOT1P1 MYOM1 PTPN2 DLGAP1-AS2 ZBTB14 RN7SL362P SMCHD1 LINC00470 PIEZO2 RNU1-109P IMPA2 down
## chr2q36 0.0015601 0.0102949 -0.5073449 -1.911858 0 46 FBXO36 FBXO36-IT1 SLC16A14 FARSB CUL3 NYAP2 PID1 TM4SF20 RNY4P19 RPL7L1P10 RN7SKP283 RHBDD1 COL4A3 MFF RNU6-613P SPHKAP COL4A4 RNU6-964P AP1S3 SCG2 MIR4439 AGFG1 ATG12P2 IRS1 down
fgsea_plot(fgsea_res$res_c2, pathways_title='C2 curated genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ---------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 0.0032258 0.0189957 0.7024960 3.446846 0 130 MCM2 HMGB2 CDKN2A TK1 EIF4EBP1 FEN1 TMSB10 CENPM POLA2 TACC3 ESPL1 PLK1 BID PRC1 HMGA1 POLQ CHEK1 SAC3D1 LMNB1 GINS4 KIF2C PTTG1 LSM4 SHCBP1 UBE2S KIF4A ASF1B CHAF1B MCM4 RACGAP1 CDC20 GTSE1 KIF20A CCNF FOXM1 DPP3 DTYMK CCNB1 CCNA2 AURKB ATAD2 KIF18B CDC6 MKI67 LRP8 TPX2 OIP5 NCAPH BIRC5 CDCA8 BUB1 MCM10 E2F1 KIF11 NEK2 SPAG5 MYBL2 ZWINT FANCI TYMS PAQR4 CCNB2 EZH2 MAPK13 CEP55 PBK BRCA1 KIF15 KIF23 GMNN SMC4 RAD51AP1 RRM2 UBE2C CENPA DTL FBXO5 DNMT3B NCAPG STIL BUB1B ASPM GINS1 HMMR TRIP13 TOP2A CENPE NUSAP1 DLGAP5 HJURP SMC2 PLEK2 AURKA MELK TTK KIF20B PAFAH1B3 TMPO CENPF ECT2 CKS2 KIF14 up
## SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 0.0032468 0.0189957 0.6828265 3.398856 0 138 HMCES TIMM10 MCM2 CDC45 TIMELESS NUDT1 FEN1 PKMYT1 TACC3 MRPL12 ESPL1 DNAJC9 GMPS PLK1 SHMT2 PRC1 TXNRD1 TUBA1B CENPN MIS18A POLQ CHEK1 PSMA7 LMNB1 JMJD6 MCM3 MCM6 KIF2C PTTG1 NCAPG2 DONSON RAD51 UBE2S KIF4A ORMDL2 MCM4 RACGAP1 CDC20 GTSE1 DSCC1 SNRPF RNASEH2A KIF20A NME1 TUBA1C FOXM1 TROAP CCNB1 DDX39A CCNA2 AURKB KIF18B MKI67 TPX2 OIP5 NUP93 NCAPH BIRC5 CDCA8 CDC25A BUB1 STIP1 MCM10 RFC4 E2F1 KIF11 NEK2 SPAG5 CCT5 MYBL2 ZWINT STMN1 BLM CCNB2 EZH2 CEP55 KIF15 RRM2 UBE2C CENPA FBXO5 QPRT NCAPG STIL BUB1B ASPM GINS1 CDK2 HMMR TRIP13 PARPBP DSN1 TOP2A TXN CENPE NUSAP1 DLGAP5 HJURP SLC7A5 AURKA MELK TTK TMPO CENPF ECT2 CKS2 KIF14 up
## CROONQUIST_IL6_DEPRIVATION_DN 0.0029070 0.0189957 0.6863885 3.206446 0 91 MCM2 HMGB2 CDC45 TK1 GALK1 POLD1 CHAF1A GMPS PLK1 LIG1 HMGA1 CHEK1 MCM7 KIF22 GPX4 MCM3 KIF2C PTTG1 MCM4 SBNO2 CDC20 NASP KNTC1 CCNF FOXM1 DTYMK CCNB1 CCNA2 TRAIP AURKB CDC6 MKI67 TPX2 OIP5 NCAPH CDC25A BUB1 KIF11 SPAG5 MYBL2 ZWINT FANCI STMN1 GALE TYMS CCNB2 BRCA1 SMC4 RRM2 DUT UBE2C CENPA STIL BUB1B PLK4 GINS1 RRP12 HMMR TRIP13 TOP2A CENPE SMC2 AURKA up
## KANG_DOXORUBICIN_RESISTANCE_UP 0.0026667 0.0189957 0.7676460 3.201687 0 51 HMGB2 ABCC1 TK1 CENPM POLA2 PLK1 PRC1 POLQ LMNB1 NCAPG2 KIF4A ASF1B MCM4 CDC20 DSCC1 RRM1 FOXM1 DTYMK ATAD2 CDC6 MKI67 TPX2 OIP5 BIRC5 CDCA8 BUB1 RFC4 ZWINT FANCI TYMS PBK RAD51AP1 RRM2 CENPA NCAPG BUB1B PLK4 ASPM GINS1 HMMR TOP2A NUSAP1 HJURP AURKA up
## WHITEFORD_PEDIATRIC_CANCER_MARKERS 0.0029940 0.0189957 0.6573277 3.180702 0 108 MCM5 CDC45 TK1 EIF4EBP1 NUDT1 GAPDH ESPL1 DNMT1 PRC1 MFN2 CENPN UHRF1 POLQ CDCA5 MCM7 LMNB2 CDCA2 ZNF367 PTTG1 CCDC34 ASF1B MCM4 RCC2 ENO1 NASP RNASEH2A TMEFF1 NME1 RECQL4 DTYMK CCNB1 CCNA2 ADCY3 ATAD2 MKI67 TPX2 MLLT11 RRP1 NCAPH BIRC5 CDCA8 CDC25A BUB1 ZNF300 RFC4 E2F1 KIF11 NEK2 GINS2 MYBL2 ZWINT STMN1 TYMS PSAT1 CCNB2 MND1 PBK SMC4 TWIST1 RRM2 UBE2C MYCN UBE2T CENPA ILF3 MEX3B PLK4 SNRNP200 TOP2A CENPE NUSAP1 ILF2 DLGAP5 CDK4 AURKA MELK TTK EIF4A1 PAFAH1B3 TMPO CENPF CKS2 KIF14 up
## CROONQUIST_NRAS_SIGNALING_DN 0.0028169 0.0189957 0.7101504 3.141126 0 68 MCM2 HMGB2 TK1 POLD1 CHAF1A PLK1 HMGA1 CHEK1 MCM7 KIF22 GPX4 MCM3 KIF2C PTTG1 MCM4 SBNO2 CDC20 NASP FOXM1 CCNB1 CCNA2 PLOD2 TRAIP AURKB CDC6 MKI67 TPX2 OIP5 NCAPH CDC25C KIF11 SPAG5 MYBL2 ZWINT STMN1 GALE CCNB2 SMC4 BRD8 DUT UBE2C CENPA STIL BUB1B PLK4 GINS1 TRIP13 TOP2A SMC2 AURKA up
## NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 0.0030864 0.0189957 0.6563273 3.140406 0 105 MRPL28 FLYWCH1 GFER PKMYT1 SNRNP25 MRPS34 TSR3 SPSB3 CHTF18 NME3 FLYWCH2 RHOT2 HCFC1R1 CLCN7 TELO2 UNKL STUB1 TBL3 EME2 TRAF7 NUBP2 KCTD5 HBA1 NDUFB10 ZNF205 PRSS21 JMJD8 AXIN1 POLR3K NME4 ZNF598 C16orf91 NPRL3 RAB26 WDR24 HAGHL SYNGR3 IGFALS PIGQ MSRB1 FAHD1 MAPK8IP3 CAPN15 UBE2I HBQ1 GNPTG RPUSD1 MPG GNG13 WDR90 MMP25 ZNF213 PAQR4 THOC6 RPS2 TNFRSF12A KREMEN2 HAGH ZSCAN10 HBA2 FBXL16 DECR2 TSC2 PRSS22 RHBDL1 up
## LI_DCP2_BOUND_MRNA 0.0027701 0.0189957 0.6868230 3.138341 0 78 AP2S1 C12orf10 UBXN6 NDUFS7 PSMC3 MRPS11 PSMC5 NDUFB7 MRPL23 ETFB CHMP2A MRPL12 CUEDC2 CHAF1A UQCRC1 DEAF1 MRTO4 BID RUVBL2 NDUFS8 MRPS12 CYC1 JMJD6 TACO1 WDR74 ENO1 HMOX2 MAP2K2 SCO2 POLR2L APEH EIF3G EDF1 ZNF593 APRT RPSA NQO2 SPEN FAM50A PHGDH FLII WDR45 DUS1L EEF1D TRIB3 TRAPPC2L NDUFA13 MTX1 DCXR NARF up
## FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN 0.0026455 0.0189957 0.7641455 3.095698 0 47 CDKN2C MCM2 MCM5 TIMELESS TK1 NUDT1 POLA2 RFC5 POLE CHAF1A POLRMT MCM7 RNF126 MCM3 MCM6 KIF2C MAZ CDC20 RNASEH2A RRM1 HOXA11 FOXM1 CCNA2 BRPF1 E2F1 TTLL4 KIF11 STMN1 PRIM1 BLM GAL up
## KIM_ALL_DISORDERS_DURATION_CORR_DN 0.0031646 0.0189957 0.6231515 3.085711 0 134 HRAS NDUFS7 PIN1 NDUFA1 MRPL23 RNH1 ETFB CLTA ATOX1 CHMP2A DHPS ECI1 TALDO1 HCFC1R1 SF3B2 RUVBL2 C9orf16 CCT7 NDUFS8 SAC3D1 AKR1B1 SPAG7 CDIPT AKR1A1 KLHL21 GPX1 ACOT7 PARP1 ECSIT GRHPR ARRB2 VPS51 ATP6V0E2 FXYD7 ESYT1 COX4I1 NDUFC1 SNRPA COX8A TRAPPC12 DPF2 CTDNEP1 NUDC PSMB5 GNPDA1 COX7A1 MADD GTF3C1 ENDOG CREB3 RPL13 AMPD2 STOML1 EIF3G NUP93 MAPK3 DCTN2 TUBA4A MAST3 EXOC3 LMAN2L HAX1 PES1 TUFM VPS28 ACTR1A OS9 EIF6 NIPSNAP1 DHX30 NDUFAF3 TMEM147 DCXR GDI1 HDGF NDUFA7 COX7C TRAP1 CX3CR1 KLK6 ATP6V0B ACTL6B FBXO9 PPIA SLC25A11 PUF60 PAFAH1B3 SUMO3 AHSA1 ACD up
## KONG_E2F3_TARGETS 0.0029070 0.0189957 0.6581561 3.071348 0 88 RBBP8 HMGB2 TK1 FEN1 INCENP TACC3 IGF2BP1 PLK1 PRC1 NCAPD2 CDCA5 LMNB1 RAD54L MCM3 KIF2C NCAPG2 SHCBP1 RAD51 ASF1B CHAF1B RACGAP1 CDC20 NASP KIF20A CCNF CCNB1 CCNA2 CDC6 MKI67 TPX2 NCAPH BUB1 KIF11 PRIM1 CCNE1 TYMS CENPH RPL3 EZH2 GP1BA RPL12 PBK BRCA1 RAD51AP1 UBE2C UBE2T NCAPG NR1D1 BUB1B IQGAP3 NUP50 HMMR F13A1 TOP2A NUSAP1 DLGAP5 HJURP SMC2 AURKA MELK up
## BURTON_ADIPOGENESIS_3 0.0028902 0.0189957 0.6574379 3.070547 0 90 MCM2 MCM5 HMGB2 CDC45 TK1 RNASEH2C FEN1 INCENP TACC3 RFC5 DNMT1 SLBP PLK1 PRC1 KIF22 MCM3 KIF2C RAD51 KIF4A ASF1B MCM4 ADAM8 RACGAP1 CDC20 NASP KIF20A RRM1 CD4 CCNF DTYMK CCNB1 SLCO3A1 CDC6 MKI67 NCAPH BIRC5 CDCA8 BUB1 TOPBP1 NUP85 MCM10 TUBB6 KIF11 PRIM1 TYMS CCNB2 EZH2 BRCA1 RAD51AP1 RRM2 DTL CSTF2 TOP2A NUSAP1 ILF2 DLGAP5 SMC2 AURKA up
## ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_6HR 0.0027855 0.0189957 0.6679265 3.066410 0 79 MCM2 MCM5 HMGB2 RANBP1 TIMELESS GINS3 CDT1 RFC5 DNAJC9 UHRF1 CDCA5 MCM7 KIF22 NCAPH2 LMNB1 RAD54L MCM3 MCM6 SAP30 RAD51 CHAF1B HAUS8 POC1A RACGAP1 KIF20A KNTC1 DTYMK GPN3 CCNA2 CDCA8 TOPBP1 RFC4 E2F1 DEK KIF11 NEK2 DCTPP1 GINS2 MYBL2 EZH2 CEP55 BRCA1 GMNN MTFR2 RPA2 UBE2T CENPA DTL FBXO5 CDK2 TRIP13 PARPBP DSN1 NUSAP1 DLGAP5 SMC2 up
## MORI_IMMATURE_B_LYMPHOCYTE_DN 0.0028329 0.0189957 0.6585894 3.052604 0 84 CDKN2C MCM2 HMGB2 CDC45 ACTN4 DNMT1 SLBP LIG1 HMGN2 PCK2 PRC1 TUBA1B CHEK1 CDCA5 MCM7 LMNB1 RAD54L MCM3 MCM6 LGALS1 RAD51 CBX1 CDC20 MTHFD2 RRM1 HNRNPAB CCNB1 CCNA2 MKI67 NCAPH GSN MCM10 NEK2 RAG1 STMN1 PRIM1 CCNB2 EZH2 CKAP5 SMC4 RRM2 UBE2C TUBB4B CENPA DTL XRCC6 IQGAP3 TOP2A TXN NUSAP1 DLGAP5 HJURP SMC2 MELK SMARCA4 TTK TMPO PRDX4 PCNA NDC80 CDKN1A SLC29A1 up
## HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 0.0032154 0.0189957 0.6077400 3.047288 0 141 CDKN2C HMGB2 CDC45 PSMC3 ANP32A TK1 PIH1D1 FEN1 INCENP ACTN4 RFC5 DNMT1 LIG1 PCK2 PRC1 TUBA1B PPP1CA CDCA5 KIF22 NCAPH2 RAD54L MCM6 CAMP KIF2C RAD51 UBE2S KIF4A CHAF1B ITGB7 CBX1 RACGAP1 CDC20 ENO1 ANP32B NASP NUDC KIF20A MTHFD2 RRM1 CCNB1 CCNA2 AURKB STIM1 MKI67 NCAPH CDC25C GSN BUB1 ABR LDHA MCM10 NEK2 FLII DCTPP1 MMP14 STMN1 CCNE1 CCNB2 ZNF358 KIF23 CKAP5 SMC4 RRM2 HOXC5 UBE2C TUBB4B UBE2T CENPA PLK4 TRIP13 RPA1 TOP2A CENPE NUSAP1 DLGAP5 ANLN COIL HJURP SMC2 AURKA up
## ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR 0.0030395 0.0189957 0.6043270 2.939099 0 116 RBBP8 MCM2 HMGB2 RANBP1 TIMELESS GINS3 POLD1 RFC5 DNAJC9 CLN6 SMPD4 PRC1 CENPN UHRF1 MCM7 KIF22 NCAPH2 ALYREF LMNB1 NEIL3 RAD54L MCM3 PTTG1 HAUS8 POC1A RACGAP1 CDC20 NASP KIF20A KNTC1 DTYMK GPN3 CCNB1 CCNA2 BIRC5 CDCA8 BUB1 TOPBP1 ODF2 RFC4 E2F1 KIF11 NEK2 DCTPP1 SPAG5 MYBL2 CCNB2 EZH2 CEP55 KIF23 MTFR2 UBE2C RPA2 UBE2T CENPA FBXO5 ASPM CDK2 HMMR TRIP13 PARPBP TOP2A NUSAP1 DLGAP5 ANLN SMC2 PLEK2 up
## CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_UP 0.0033003 0.0189957 0.6007683 2.933444 0 131 AP2S1 CDC45 TK1 EIF4EBP1 MZT2B MZT2A CHAF1A GMPS MICALL1 SHMT2 PRC1 UHRF1 SLC35G2 KPTN SLC7A1 LMNB1 FBXO17 PTTG1 SNRPA LARP1 C19orf48 PCBD1 UBE2S ASF1B TRIM28 MCM4 GTSE1 RNASEH2A NOP16 KIF20A NUP210 MTHFD2 CHMP7 CCNB1 PCGF1 PRAF2 ATAD2 CDC6 MKI67 TPX2 KIF3C MLLT11 NCAPH BIRC5 SH3KBP1 AFAP1L2 ERCC1 BUB1 SCNM1 TFAP2A-AS1 SPAG5 SAE1 PRR11 BOLA3 CCNB2 SMC4 RRM2 UBE2C MTA3 TNFRSF9 NCAPG BUB1B DGAT1 POLR3D ASPM PWWP2A IQGAP3 DYSF HSPA9 TOP2A CENPE NUSAP1 NPM1 WDR76 ADAM19 DLGAP5 HJURP AURKA GRAMD1A WDFY2 TTK RPL8 CENPF CKS2 AFAP1L1 LINC00839 up
## KUUSELO_PANCREATIC_CANCER_19Q13_AMPLIFICATION 0.0023981 0.0189957 0.8133046 2.906337 0 27 AKT2 FBL C19orf47 PAF1 EID2 MED29 LRFN1 SUPT5H TIMM50 DYRK1B PSMC4 PLD3 GMFG CNTD2 SAMD4B MAP3K10 FCGBP CLC RPS16 up
## FAELT_B_CLL_WITH_VH3_21_UP 0.0025063 0.0189957 0.7409996 2.903549 0 41 TK1 PRKCSH STXBP2 VCP PKMYT1 TOMM40 ZBTB48 UBTF ACTN4 EIF4G1 HMGA1 TOP3B PPP5C CDK16 KCNAB2 FAM214B SBNO2 MYO9B SAFB SRC SASH3 CALR CLUH PTPN7 DVL1 TYMS SMG5 YKT6 SMARCD1 BCR up
## GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN 0.0028818 0.0189957 0.6262496 2.890958 0 83 PPIF MCM2 MCM5 CDC45 TK1 FEN1 SNRNP25 NPM3 CENPM PRC1 CHEK1 SAC3D1 COTL1 MCM6 KIF2C MCM4 RACGAP1 CDC20 DSCC1 RNASEH2A RRM1 CCNA2 KIF18B CDC6 OIP5 BIRC5 GZMB CDC25A BUB1 NUP85 MCM10 RFC4 KIF11 GINS2 ZWINT CCNE1 TYMS CSF2RB CCNB2 LAT HBB CEP55 KIF15 GMNN RAD51AP1 RRM2 DUT DTL NCAPG BUB1B GINS1 MINPP1 TRIP13 TOP2A NUSAP1 DLGAP5 SMC2 SLC7A5 MELK up
## ISHIDA_E2F_TARGETS 0.0026178 0.0189957 0.7057140 2.884347 0 48 CDKN2C HMGB2 TK1 FEN1 CDT1 SLBP LIG1 PRC1 MCM3 KIF2C PTTG1 RAD51 ASF1B CDC20 RRM1 CCNB1 CCNA2 AURKB MKI67 NCAPH BUB1 DCTPP1 STMN1 PRIM1 CCNE1 CCNB2 EZH2 RRM2 DUT UBE2T CDK2 TRIP13 RPA1 TOP2A NUSAP1 ANLN SMC2 up
## WELCSH_BRCA1_TARGETS_DN 0.0031746 0.0189957 0.5893135 2.874279 0 127 NOS2 HRAS MCM2 HK1 CLTA SSRP1 CHD4 GALK1 POLD1 PKN1 NME3 CHAF1A MOGS SF3B2 CCDC85B MRPS12 POLRMT LMNB2 CYC1 APEX1 SEC24C POLG CAD CDC37 SLC1A5 CKAP4 PRKACA FARSA FKBP4 AP3D1 SAFB P2RX4 TAF1C TCOF1 PPM1F ANXA11 RXRA PDCD11 SF3A3 ALG3 SNRNP70 RCC1 CCNE1 DDX11 PWP2 PMPCA GAL FASN BOP1 SRM RABEPK PHKG2 HSP90B1 DDT TRAP1 RASSF7 RAE1 SCAP EDC4 CDK4 SLC7A5 SMARCA4 MTHFD1 DNTTIP2 PIEZO1 SKIV2L VDAC1 STC1 EIF3B GCSH SLC29A1 RPIA EMG1 up
## CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 0.0032895 0.0189957 0.5614877 2.863465 0 164 COLCA2 MCM2 HMGB2 PKM ABCC1 FEN1 SLC16A3 TMEM51 PRC1 VEGFB RMI2 CDCA5 LMNB1 FUNDC1 KIF2C PTTG1 SHCBP1 KIF4A SLC1A5 CKAP4 ELF4 RACGAP1 CDC20 HK2 DSCC1 KIF20A FOXM1 CCNB1 CCNA2 G6PD CKAP2L AURKB KIF18B CDC6 MKI67 TPX2 OIP5 TUBA4A BIRC5 B3GNT5 SOX9 CYBA PNMA1 RFC4 KIF11 NEK2 ZWINT FANCI CHST11 PRR11 CCNE1 SLC7A7 DBN1 CCNB2 SALL2 EZH2 MAPK13 B4GALT5 CEP55 PBK KIF23 SMC4 RAD51AP1 H19 UBE2C FHOD3 TTF2 DTL FBXO5 CMTM3 BUB1B ASPM SPHK1 SLAMF8 TRIP13 ARID3A TOP2A CENPE NUSAP1 MARCKS DLGAP5 ANLN HJURP AURKA TMEM65 GLIS2 DEPDC1B TTK FMNL2 PAFAH1B3 CENPF ECT2 YBX3 KIF14 ORC6 ZNF532 MMP9 IGF2BP3 MAD2L1 NDC80 CTBP2 FAM118A TMED3 up
## REACTOME_DNA_STRAND_ELONGATION 0.0024272 0.0189957 0.7680023 2.856200 0 31 MCM2 MCM5 CDC45 FEN1 GINS3 POLA2 POLD1 RFC5 LIG1 POLD4 MCM7 MCM3 MCM6 GINS4 MCM4 RFC4 GINS2 PRIM1 RPA2 GINS1 POLD2 RPA1 up
## RHODES_UNDIFFERENTIATED_CANCER 0.0028011 0.0189957 0.6501536 2.843208 0 64 MCM2 HMGB2 NUDT1 TMSB10 PSMD2 ADRM1 NCAPD2 MCM3 MCM6 GCLM KIF2C UBE2S CDC20 NME1 MTHFD2 FOXM1 CCNB1 CCNA2 CEBPG CDC6 NCAPH BIRC5 CTSL RFC4 MYBL2 YBX1 IFI30 EZH2 KIF23 PSMB7 UBE2C CENPA TRIP13 TOP2A ILF2 DLGAP5 SLC7A5 MELK EIF2S2 CKS2 KIF14 PRDX4 PCNA MAD2L1 up
## SANSOM_APC_TARGETS_REQUIRE_MYC 0.0035971 0.0189957 0.5343889 2.831266 0 209 AAAS FBL PTOV1 TIMELESS ATG9B MBD3 TK1 HOXA9 RNASEH2C ASCL2 MUS81 EPHB2 FADS3 ZBTB48 THOP1 POLE DUS3L TELO2 BID SHMT2 SMPD4 CCT7 WDR62 MCM7 WDR54 LMNB2 RAD54L MCM3 NELFA SIVA1 WDR34 ARX QTRT1 CAD HAGHL PPP1R14B CCDC86 RCC2 DDX49 GTSE1 NASP SNRPF RNASEH2A NME1 CENPP PRSS41 DTYMK TXNRD2 MAPK7 SIGMAR1 MVK BCL11A SMYD5 SYTL1 SLCO3A1 GRWD1 STOML1 LHPP LRP8 RGS12 CREBBP ERCC1 LDB1 NFKB2 ZMYND19 PHGDH RASSF4 GTPBP3 IFFO2 GINS2 SFSWAP MRPL38 ZNF213 RAD23A MUTYH MYBBP1A RANGRF NTMT1 RRP9 SLC1A4 OGG1 TNFRSF12A HIRA TMEM141 ALKBH2 POLR1A TRDN FADS2 SRM SAPCD2 TFIP11 AAR2 BUB1B PPAN SLC29A2 ZNF444 TRIM9 RNF157 POMT1 GORASP1 TGIF2 CDK4 KNOP1 NOP56 NBEAL2 NHP2 MED22 ATRIP USP20 TMPO D2HGDH YBX3 GIPC1 NEUROG3 EMC8 LFNG POFUT1 DRG2 SNRPG up
## SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 0.0029851 0.0189957 0.5922922 2.825200 0 101 RBM42 PKM KCNH2 SUPT5H RNH1 NDUFV1 TMED9 UBTF NUP62 AIP PPP2R1A MLF2 C9orf16 KAT5 UQCR11 PRPF19 DNPH1 TAF6L AHCYL1 OSM IDH3B STK11 OGFR PPP5C CYC1 ARHGDIA UBE2M KCNAB2 UBE2S TMEM109 MED24 SLC2A5 OTUB1 MAZ CABIN1 SYMPK CCNF PDAP1 AURKB P4HB HGS SUPT6H ZNF593 ERCC1 SF3A2 MAST1 CLPTM1 CYHR1 LCK JAK3 RAD23A NCOR2 GUK1 BRD3 HDGF NFATC2IP NUP50 TCF25 BCR RGP1 KXD1 SYNGR2 up
## SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP 0.0025510 0.0189957 0.6986835 2.814297 0 44 PKM HCK PSME2 ALDOA CLTA THOP1 PLOD1 PFKP HMGA1 PGAM1 MCM7 SLC1A5 ENO1 NME1 MTHFD2 CCNB1 P4HB PRDX1 IDH2 LDHA SNRPB CCT5 IFI30 CTSD CENPA BCL2A1 TRAP1 PSMC1 DLGAP5 TFRC MELK HSP90AB1 HSPD1 up
## MISSIAGLIA_REGULATED_BY_METHYLATION_DN 0.0030960 0.0189957 0.5809341 2.812469 0 114 CDKN2C FBL MCM5 HMGB2 RANBP1 CDC45 TK1 CENPM NDUFS3 CDT1 MTFP1 RFC5 ESPL1 DNMT1 HNRNPA1 GMPS LIG1 HMGN2 PRC1 CHEK1 KIF22 ALYREF LMNB1 CAD SNRPA RAB26 TRIM28 ANP32B RNASEH2A NCAPD3 RRM1 KNTC1 HNRNPAB FOXM1 DTYMK CCNA2 CDC6 MKI67 NCAPH CDC25C RFC4 DEK RCC1 NEK2 HNRNPL ZWINT STMN1 PRIM1 TYMS FASN EZH2 MICU1 KIF23 GMNN SMC4 DUT MDFI SNRNP40 UBE2C FOSL1 ILF3 BUB1B MSH6 POLD2 CENPE NUSAP1 ACAT2 DLGAP5 SMC2 AURKA HMGB1P10 PRKDC TMPO CENPF PIR KIF14 ITGB4 up
## SONG_TARGETS_OF_IE86_CMV_PROTEIN 0.0027174 0.0189957 0.6692993 2.800793 0 52 UNG MCM2 MCM5 HMGB2 TK1 DDX23 CDT1 DNAJC9 MCM7 MCM3 MCM6 UMPS PTTG1 CORT NASP RRM1 FOXM1 TPX2 TMEM106C TOPBP1 E2F1 KIF11 MYBL2 PPIH ZWINT BLM CCNE1 TYMS EZH2 up
fgsea_plot(fgsea_res$res_c3, pathways_title='C3 regulatory target genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ---------------------- ---------- ---------- ----------- ---------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## MIR1250_3P 0.0012092 0.0125369 -0.4285983 -2.256037 0 464 TRDMT1 ZC3H6 TIA1 UBE2W TMEM106B IMPG1 VAMP4 PCMTD1 ZNF597 CREB1 ZDHHC21 CNTN4 RAB11FIP2 DSTN CLOCK TRIP11 SMAD5 ERBB4 PAPOLG SCAI C8orf34 PTPN4 ZMAT1 CLHC1 DNAJC27 ATG2B SRSF2 CNOT6 SLC4A4 UBE2K PUM2 USP14 RC3H1 CHURC1 SPOPL GPM6B VAPB CHD9 FRMPD4 ZNF326 MOB1B OMA1 SLC35F5 ATP8A1 RPS6KB1 SLC18A2 PGAP1 GNPAT RCAN2 SLC12A2 DAAM1 RPGRIP1L TOR1AIP2 STXBP5 SLC16A7 SCNN1G TFB1M TMTC4 PLGLB1 SLC38A2 RAB27B ARHGAP29 ANKRD46 TCTEX1D1 CNIH1 THAP2 ATXN3 PTGFR PTBP3 PDS5B SNTB2 DICER1 CCNC NTRK2 HOOK3 GABPA CA5B SPATA6 CLDN8 ZBTB41 TMEM135 PANK1 MAB21L3 NPY1R ZNF138 SLC36A4 SREK1 GUCY1A2 ONECUT2 MAP3K2 MBNL3 RAB8B CENPC LAMTOR3 ADRA1A RNF138 SCEL KNDC1 DENND1B TNPO1 TM4SF18 NIPA1 PDS5A SPCS3 MYCT1 SLC6A4 ARF4 RPAP2 ZNF512 EXOC5 GREM2 BMPR2 PTPRB TMEM33 TRMT5 PHIP CHMP2B SESN3 PNISR A1CF SSR1 RIF1 ZSCAN16 CAST RAPH1 UBA6 PLCXD3 SEMA5A CCDC82 LPGAT1 ZNRF3 MMAA ELL2 IKZF2 ADAMTS6 ACSL6 NDUFS1 WARS2 TNKS KLF12 C5orf24 ZMAT3 RBL2 PICALM TMF1 HEATR1 GPATCH2L HERC4 AMD1 EBF2 ATE1 AQP11 AKAP11 GPCPD1 IGF1 ATL3 ATG14 ZIC5 LIPA COL8A1 SGMS1 FAM117B STK17A POU2F1 GALNT13 MFAP3L PDCD6IP CHIC1 SGIP1 PPP4R2 RFTN1 ARMC3 BMP7 VGLL3 PRKAB2 APBB2 ISCA1 RAB11A CACHD1 PAN3 PTPN21 LGALSL FBXO48 SGCD POGK SOX6 MYCBP2 DOK6 CSRNP3 SYT4 GPR34 PDE1A TMOD2 IRS1 RBM11 GRAMD1C VIT IPO7 FRK ZFAND6 PSD3 NAP1L3 SKIL QKI LPCAT2 COBLL1 BCAT1 FUT9 KIF5B EFEMP1 FAM214A RIMKLB IFNG CTNNA3 FUBP1 PCDH10 NKX2-1 DCUN1D4 CACNB4 SLC10A2 RSBN1 down
## MIR607 0.0011062 0.0125369 -0.4106356 -2.250685 0 906 KIAA0825 IGIP CD302 GTPBP10 ZDHHC15 TMEM106B VAMP4 PCMTD1 TYW5 CCNT2 CREB1 ZDHHC21 ETV1 KIAA0408 POLR2M TMEM260 KLHL28 CNTN4 RAB11FIP2 CRYZL1 CLOCK TRIP11 MAMDC2 SMAD5 PAPOLG ABHD13 ERCC6L2 SCAI C8orf34 PTPN4 KIAA1109 ACVR2A CFTR LMO7 CWC22 SOCS4 CCZ1B LRP2BP SLC30A7 SRSF2 TMED7 TTC14 THAP9 ZNF708 RC3H1 SPOPL TRAPPC13 USP53 SUCO TSNAX TMEFF2 PPIL6 NUFIP2 TSPAN12 EXTL2 REEP1 ZBTB1 MOB1B CHM ATG4C C9orf72 UBLCP1 CDKL1 RCHY1 ZFYVE16 AP1G1 TTC39B PFKFB2 INO80D RPS6KB1 LYSMD3 PGAP1 NEGR1 STXBP4 RCAN2 RNF180 UBE2B SLC12A2 APPL1 STXBP5 KL SLC16A7 MED13 CEACAM5 FSD1L DBT MDM4 PTPN12 ARL5A ELK4 RUFY2 PGR SAR1B CTNND2 THAP2 REEP3 RFTN2 ATXN3 CCNYL1 KDELR2 PTBP3 SMAD2 CRIPT NFAT5 GTF2A1 DNM3 RICTOR PDS5B DUS4L NAA16 HOOK3 GABPA SLC25A24 RBBP9 HTR1F YTHDF3 CCDC126 MFAP3 DLGAP1 SH3BGRL2 DNAJC3 AASDH NRG3 ZNF770 GJA1 ZBTB41 PURB FAM13B PIAS2 PREPL GABRA2 NDUFA5 LZIC MOSPD1 THAP6 BIRC6 CUL3 FBLN5 ALS2 PRPF4B YTHDC2 AK7 ERP44 ARIH1 CNOT8 RORA STRBP ZNF471 FRS2 NPY1R GPM6A CXADR LIN7A DDX52 RASA2 GUCY1A2 ONECUT2 MAP3K2 SSBP2 MBNL3 ZFR RAB8B SLC38A4 NUDT21 SP4 C2orf49 NKIRAS1 PRDM5 DENND1B PDE8B TM9SF3 NIPA1 SPCS3 REPS2 ITM2B FMR1 NCKAP1 ZC3H14 TSPAN13 ARRDC3 TMEM170B CDH6 TRPC6 WWC3 FBXW2 KANSL1L INTS6 NFIA ZKSCAN8 MTMR9 ARHGAP12 UBXN2B TMEM245 SPAG9 SERINC1 PRTG MTMR10 SPIRE1 TOX WDR17 ZNF112 BMPR2 TCF12 TEX10 FGF7 PTPRB TMEM33 PDZD2 SYPL1 RAPGEF6 CBLL1 NNT SPRY2 FGL1 MPP4 CASQ2 ARL5B PHIP ASF1A EOGT IKZF5 AGPS MSRB3 NMBR API5 DNAH10 VPS26A PNISR FOXN2 CNKSR2 MAB21L1 ZFP91 RIF1 C1orf146 HSPB3 LYPLA1 C1GALT1 SUZ12 SEMA5A NAALADL2 PCNP PLEKHA1 LPGAT1 DPY19L3 FOXF1 AGAP11 DENND4A CTBS MITF MBTD1 FOXJ3 DDX5 ALG10B ATP10D ZBTB8A PRKAA2 GPAM NDUFS1 SLC35A3 EIF1AX AFF4 RBM18 KLF12 FAM13C TEX30 PREX2 C10orf90 BIVM COG5 ZMAT3 TMF1 MTMR12 XKR9 C2orf88 ANKRD28 MMP16 TRA2A MCTS1 KIAA1841 CADM2 RECK LHCGR ETNK1 GPHN FAM126A MIB1 EDNRA SCML1 TRIM71 POGLUT1 TRPC5 AKAP11 MIA3 NAPB TET1 IGF1 C15orf41 GIPC2 BTBD3 MBTPS2 SLC25A46 SPAG16 AHR PRKACB ICK ZFC3H1 MGAT4A SERPINB4 PARP8 GPATCH11 PDCD6IP CHIC1 PRRC2C UBE2D1 PPP4R2 LCORL S100PBP BMP3 ENPP1 PPP1R3B NAA30 DCX TTC33 DCUN1D1 SYNPO2 MAP3K7 SERPINB3 VGLL3 AGFG1 GTF2I ZNF717 PARP11 PRKAA1 BLOC1S6 GNAQ SIRT1 SV2C IL5RA SWAP70 SLC44A1 DLD NRBF2 ZNF454 SUPT3H APOOL BACE2 PIK3CA POGK TACC1 NEK1 DOK6 NECAP1 CCDC71L STX12 CSRNP3 PPP2R2A C5orf49 SH3BGRL NSUN6 CSPG5 ELAVL2 ENPP5 CNST ARFGAP3 SLIT2 STRN CNTN1 GLRB LRRC8B IMPA1 PDHB NEK7 MACROD2 MDM1 CCNT1 PKNOX1 PEX13 COA1 SMC5 TMEM59 CPSF6 HMGCS1 CTSE CEACAM8 TWSG1 PTBP2 JAG1 CBFB TLL1 TMEM43 AZIN1 QKI BZW1 COBLL1 BCAT1 GOLGA6L9 FUT9 C2orf72 SP3 TRPC5OS PCDH15 CYP4V2 IFNG TP53BP2 IDI1 UNC5C KLF7 RPRD1A down
## MIR4677_5P 0.0013405 0.0125369 -0.4545672 -2.228793 0 236 SOX14 TCAIM PIGF CCNJ TSPAN2 ANKHD1 ZDHHC21 ETV1 ORC4 PPARGC1A DNAL1 MAP4K3 ERCC6L2 SCAI PLEKHA3 ZMAT4 SOS1 SH3GLB1 STXBP3 ZNF277 BTBD7 SRP19 FAM98B RASSF8 FBXO36 CEPT1 INO80D GCSAM TTC3 SLC18A2 RASEF DAAM1 TMEM209 NRXN1 KCNJ13 TSTD2 ELK4 MYL1 CRIPT TMPRSS11D NFAT5 YOD1 ODF2L HUS1 IQCH ENTPD1 CBR4 ALS2 RORA CHML NPY1R EIF2S1 CRISP3 ONECUT2 MBNL3 GFM2 NBEA DTD2 C3orf35 CSNK2A1 SEMA6D LAMP3 KLF3 FBXW2 METTL21C GATAD1 PPP1R21 TCF12 FGF7 RAPGEF6 SEMA3D PTPN3 COL4A3 CAST PLCXD3 EXOC6B LPGAT1 FOXF1 UST MOCS2 B3GALT1 C2orf88 KCNA1 SLC10A7 TTC30B down
## MIR3168 0.0014306 0.0125369 -0.4844174 -2.223422 0 126 TMEM106B KATNBL1 CA8 BRWD1 TSPAN2 ZDHHC21 ORC2 LZTFL1 NECAB1 PAPOLA BNIP2 RNFT1 FAM126B UBR3 VAPB PHF11 SPA17 RCHY1 RASEF TOR1AIP2 TMED5 NFAT5 CLCC1 SLC39A9 CROT CCDC91 RAP1GDS1 RORA ZNF644 NR2C1 SP4 PCYOX1 ZMYM2 PROX1 PIK3C2A NFIA BMPR2 SLAIN2 ERICH2 BMPR1A DIP2C PLEKHA1 ALG10B ZMAT3 ANKRD28 MMP16 SCML1 MBLAC2 TXLNG ITGA8 DUSP6 FAM117B DYNC1I2 TTC28 MGA ARMC3 down
## MIR7_1_3P 0.0011587 0.0125369 -0.4112552 -2.211813 0 619 FGF14 HMGCLL1 MBNL2 CC2D2B SLC9C1 PTAR1 EID1 CCNT2 CDH19 STAM2 TM9SF2 PPARGC1A SLC19A2 TMX3 MED6 ANGPTL3 GGPS1 CTDSPL2 ABHD13 MYSM1 PTPN4 TMEM220 FAM184A SENP7 BNIP2 PIGM CNOT6 AQR USP34 SOS1 PDE4D USP14 RC3H1 ZMYND11 ZNF23 GOPC MAPK1IP1L TMEFF2 SPIN1 NUFIP2 ROBO2 UPRT REEP1 CDC73 CHM GLCE APC SF3B1 CLCA4 ZFYVE16 PTGS2 INO80D FBXO28 ATP8A1 ZMYM5 SRSF11 PMS1 GMFB SLC5A7 NRXN3 GRIA1 UFM1 SCYL3 PGAP1 RAB18 SLC12A2 RPGRIP1L TOR1AIP2 STXBP5 EML5 FSD1L NRXN1 CDC27 PTP4A1 ANKRD46 FER SLC30A5 CPEB2 BCLAF1 CTNND2 THAP2 REEP3 IREB2 NMT2 GTF2A1 SEC23IP PDS5B DICER1 EIF4E HOOK3 SLC25A24 RPS6KA3 GAB1 YOD1 YTHDF3 RAB2A CCDC126 EDEM3 SREK1IP1 SH3BGRL2 GJA1 ATAD1 PIAS2 DNAH14 CAMSAP2 VPS41 PCDH9 CDH10 GPM6A PDE5A CXADR ARHGAP42 CCSER2 ACTR10 GUCY1A2 AQP4 ONECUT2 MAP3K2 MBNL3 ZFR C2orf69 BTF3L4 CMPK1 RNF138 CEP350 SENP6 MAST4 SCEL DENND1B PRKAR1A RWDD3 NFE2L2 TM9SF3 ZMYM2 PRICKLE2 KLF3 TMEM170B N4BP2L1 GPR180 TMPRSS11A KHDRBS2 CNR1 ARHGAP12 TMEM245 ZFP42 PRTG EXOC5 TMEM47 NUCKS1 FGF7 FAT4 TMEM33 HCFC2 PHF20L1 SETD2 RAPGEF6 MIER3 WDR48 CBLL1 RBM12 EEF1E1 RNF111 ASF1A NPAS3 FGFR1OP2 SESN3 LCLAT1 RBM7 VPS26A FOXN2 GPR22 SLC25A16 GOLGA7 UHMK1 RIF1 TBC1D32 FBXL3 EPS15 DIP2C TMEM181 ZFX KHDRBS3 ELL2 ANK3 DPY19L3 TOR1AIP1 ATL2 MAPK9 GULP1 MANEA SLC35A3 AFF4 KLF12 TAOK1 FAM13C SLAIN1 C5orf24 PICALM GPATCH2 ITPR2 SMIM14 KIAA1841 SMNDC1 TAL1 HNRNPA3 FNIP1 GRIA3 CADM2 SLC10A7 TTC30B ETNK1 FAM126A MIB1 EBF2 CNOT7 PDGFA MBLAC2 AMMECR1 EXOC6 DLG2 FZD8 AHR RORB SLC39A8 DDX6 MGAT4A ARHGEF7 down
## MIR7_2_3P 0.0011601 0.0125369 -0.4111678 -2.210796 0 617 FGF14 HMGCLL1 MBNL2 CC2D2B SLC9C1 PTAR1 EID1 CCNT2 CDH19 STAM2 TM9SF2 PPARGC1A SLC19A2 TMX3 MED6 ANGPTL3 GGPS1 CTDSPL2 ABHD13 MYSM1 PTPN4 TMEM220 FAM184A SENP7 BNIP2 PIGM CNOT6 AQR USP34 SOS1 PDE4D USP14 RC3H1 ZMYND11 ZNF23 GOPC MAPK1IP1L TMEFF2 SPIN1 NUFIP2 ROBO2 UPRT REEP1 CDC73 CHM GLCE APC SF3B1 CLCA4 ZFYVE16 PTGS2 INO80D FBXO28 ATP8A1 ZMYM5 SRSF11 PMS1 GMFB SLC5A7 GRIA1 UFM1 SCYL3 PGAP1 RAB18 SLC12A2 RPGRIP1L TOR1AIP2 STXBP5 EML5 FSD1L NRXN1 CDC27 PTP4A1 ANKRD46 FER SLC30A5 CPEB2 BCLAF1 CTNND2 THAP2 REEP3 IREB2 NMT2 GTF2A1 SEC23IP PDS5B DICER1 EIF4E HOOK3 SLC25A24 RPS6KA3 GAB1 YOD1 YTHDF3 RAB2A CCDC126 EDEM3 SREK1IP1 SH3BGRL2 GJA1 ATAD1 PIAS2 DNAH14 CAMSAP2 VPS41 PCDH9 CDH10 GPM6A PDE5A CXADR ARHGAP42 CCSER2 ACTR10 GUCY1A2 AQP4 ONECUT2 MAP3K2 MBNL3 ZFR C2orf69 BTF3L4 CMPK1 RNF138 CEP350 SENP6 MAST4 SCEL DENND1B TNPO1 PRKAR1A RWDD3 NFE2L2 TM9SF3 ZMYM2 PRICKLE2 KLF3 TMEM170B N4BP2L1 GPR180 TMPRSS11A KHDRBS2 CNR1 ARHGAP12 TMEM245 ZFP42 PRTG EXOC5 TMEM47 NUCKS1 FGF7 FAT4 TMEM33 HCFC2 PHF20L1 SETD2 RAPGEF6 MIER3 WDR48 CBLL1 RBM12 EEF1E1 RNF111 ASF1A NPAS3 FGFR1OP2 SESN3 LCLAT1 RBM7 VPS26A FOXN2 GPR22 SLC25A16 GOLGA7 UHMK1 RIF1 TBC1D32 FBXL3 EPS15 DIP2C TMEM181 ZFX KHDRBS3 ELL2 ANK3 DPY19L3 TOR1AIP1 ATL2 MAPK9 GULP1 MANEA SLC35A3 AFF4 KLF12 TAOK1 FAM13C SLAIN1 C5orf24 PICALM GPATCH2 ITPR2 SMIM14 KIAA1841 SMNDC1 TAL1 HNRNPA3 FNIP1 GRIA3 CADM2 SLC10A7 TTC30B ETNK1 FAM126A MIB1 EBF2 CNOT7 PDGFA down
## MIR3662 0.0011086 0.0125369 -0.4024399 -2.204443 0 897 SERPINB13 GDAP2 ALG11 FGF14 GTPBP10 MAPK8 CA8 B3GALT2 GNPDA2 PTAR1 BRWD1 PCMTD1 NDFIP2 CREB1 ZNF510 RANBP3L KIAA0408 CGGBP1 ORC4 TRAK2 DNAL1 CLOCK MAP4K3 CTDSPL2 LZTFL1 PIGN DNAJB14 ERBB4 PRPF39 SCAI PTPN4 SMARCAD1 PBRM1 SOCS4 HS3ST5 PLEKHH2 RCOR3 SLC30A7 PAPOLA SRSF2 ZBTB6 FKTN CNOT6 FNDC3A UBE2K USP44 PDE4D ZNF451 ARL15 HHIP RC3H1 CAB39L GPM6B GOPC PCSK2 USP53 FAM126B FGG VAPB C5orf51 THOC2 FAM216B NUFIP2 SNX13 BTBD7 ZBTB1 ZNF326 MOB1B RASSF8 PDE6C TAB3 ZNF268 ACADSB FGA INO80D ANGPTL1 GABRB2 LYSMD3 RNF2 PGAP1 RAB18 PIK3C2G APPL1 EFCAB7 TOR1AIP2 STXBP5 KL ZNF385B SLC16A7 NCAM2 NRXN1 RAB27B ARHGAP29 FBXO38 ELK4 RTKN2 FER SOX21 RUFY2 UBR1 PGR HEATR5A SOGA3 SAR1B REEP3 VPS36 COPG2 MGST3 RAB28 C8A NFAT5 GTF2A1 RICTOR LRRN3 PDS5B NAA16 DICER1 EIF4E CCNC HOOK3 GABPA DPP4 SRBD1 EPC2 PTPRD BAZ2B EDEM3 GPR1 SCN1A HUS1 EVI5 CNTN3 FAR1 YIPF5 TMEM135 PIAS2 PREPL NDUFA5 ZC3H12C HMCN1 HECW2 CALCRL SPON1 RORA PIGK CAMSAP2 XG VPS13A LMO3 SIKE1 ANKRD12 PCDHB16 FARP1 BAAT GPM6A CXADR ARHGAP42 LIN7A SREK1 TMEM144 LSAMP MAP3K2 PAQR3 MBNL3 LIFR CLDND1 MAP4K5 MTMR6 NR2C1 CDC14B DOCK7 LIN7C GPR18 MAST4 SLC9C2 PRDM5 DENND1B TNPO1 VKORC1L1 YY2 GRIA4 PHF3 EPHA7 TRPC3 ELMOD2 POU1F1 SPCS3 REPS2 FMR1 RP1 SFPQ KLF3 APPBP2 PDE8A XPR1 PCDH20 INTS6 TOMM20 SYNCRIP CPNE3 ZKSCAN8 CNR1 MTX3 ARHGAP12 TMEM245 PRTG EXOC5 TOX HDX TMEM47 EXPH5 BMPR2 TTLL7 FGF7 FAT4 PTPRB TMEM33 CBLL1 MSANTD2 ZNF197 SGCB PPM1B ADAT2 PDE1C NPR3 EEF1E1 RUNX1T1 ZNF649 GUF1 EOGT RALGAPA1 IKZF5 VSIG1 RNF170 RHBDD1 MMRN1 RAB21 LCLAT1 LGALS8 RBM7 PNISR GAN KCNJ3 ATG10 TBC1D32 BMX C1GALT1 PHACTR2 ZFX PCNP ACER3 PLEKHA1 IKZF2 RB1CC1 MBTD1 UGT1A10 ZBTB24 ALG10B GULP1 PRKAA2 MANEA PHYHIPL EIF1AX KLF12 MIER1 TAOK1 CCL16 EBF3 TRIM23 C5orf24 BIVM ZMAT3 TMF1 MFF ZC3H8 ERLEC1 ANKRD28 UNC13C MMP16 PCP4L1 HIPK1 CNTD1 GPATCH2L SH3D19 WDR20 CADM2 ZDHHC2 ETNK1 TMEM182 ST8SIA6 ATE1 EPM2AIP1 ZEB1 MBLAC2 GOLGA8M IGF1 CDC42BPA MAPRE2 ATAD2B STAG2 XIAP ARHGAP28 AMMECR1 CELF2 MBTPS2 SLC25A46 RAD1 SLC39A10 PRKACB ICK FAM117B FGFR1OP MGAT4A ZADH2 GALNT13 SEC22C DYNC1I2 EPHA3 MFAP3L PLEKHA5 SDHC SHC4 MEF2C SGIP1 UBE2D1 LCORL LRRTM3 PPP1R3B NAA30 TNFRSF11B DCUN1D1 SLC35F1 PDE10A SYNPO2 CTTNBP2NL PRPF40A FAM133B YME1L1 SEC62 PLAG1 AGFG1 PRKAA1 RALGPS1 MED1 MYOZ2 TEDDM1 NRP1 down
## MIR3606_3P 0.0012887 0.0125369 -0.4295436 -2.194753 0 332 TRDMT1 CARF KLHDC1 ZNF678 CDH19 CREB1 ZDHHC21 RANBP3L ANGPTL3 ANGEL2 CTDSPL2 SLC30A6 ABHD13 SCAI SMARCAD1 CNOT6 UBE2K RC3H1 SH3GLB1 TSNAX NUFIP2 CDC73 ZNF326 MOB1B NCBP1 RASSF8 SLC35F5 ZFYVE16 ZNF22 CYBRD1 PGAP1 NT5DC1 SLC12A2 APPL1 TOR1AIP2 STXBP5 MED13 RXFP1 FSD1L MDM4 C14orf28 PTP4A1 ARHGAP29 ITCH CALB1 ELK4 RUFY2 CCDC39 RICTOR UEVLD ZC2HC1A GAB1 MTM1 YTHDF3 ZBTB41 LEPROT HIBCH NDUFA5 DCAF10 CUL3 PRPF4B ICA1L ENKUR DR1 CXADR SREK1 LSAMP ZFP28 LRRC3B MBNL3 RAB8B SAR1A GYPA PTEN RNF138 RELN TNPO1 ZNF714 SLC2A13 IL6ST RNF146 SPG11 FMR1 SLC6A4 RANBP9 TMEM170B PDE8A GPR180 SPIRE1 HDX TCF12 UFL1 PTPRB TMEM33 PHF20L1 SYPL1 PHIP FGFR1OP2 PCDH8 SHANK2 BMX FAM118B LYPLA1 SEMA5A IKZF2 ZBTB8A DRD1 AFF4 C5orf24 ALDH6A1 SPRYD7 TMF1 WDR20 CADM2 ZDHHC2 ETNK1 DGKI BOLL UBE2D3 SLC25A46 PRKACB CDK19 SERINC5 TTC28 CHIC1 ELF1 SGIP1 LCORL WASF3 FBXO4 AGFG1 PPP2R1B TWF1 FSBP SLC22A5 PIK3CA NEDD4L SUV39H2 CSRNP3 SMARCA1 SYT4 GTF2H5 RUNDC3B ELAVL2 CNST STRN MATR3 ABI1 CHST9 LRP6 AZIN1 CNOT6L FUT9 TOP2B SP3 ZNF320 KIF13A CACNB4 SEC23A RNF103 NDUFB8 MTF2 TRGC1 ALCAM RPS6KA5 down
## MIR186_5P 0.0012019 0.0125369 -0.4125462 -2.189752 0 529 CYP20A1 ZDHHC15 CA8 MBNL2 PTAR1 PCMTD1 RANBP3L KIAA0408 EPC1 ZC3H12B MAP4K3 SCAI SNRNP48 PTPN4 NECAB1 SOCS4 VPS13C SLC30A7 TMED7 UBE2K KPNA3 PDE4D DMD RC3H1 CHURC1 MAPK1IP1L FAM126B FKBP7 UBR3 FAM122A TMEFF2 CHD9 GCC2 MOB1B CHM ZFYVE16 CEPT1 TRAPPC8 INO80D RPS6KB1 RNF2 NEGR1 RNF180 PACRGL FEZ2 STXBP5 ZC3H11A ZNF117 FSD1L TRMT10A CALB1 TCTEX1D1 REEP3 MTMR7 CYP39A1 COPG2 NFAT5 PDS5B NAA16 DICER1 HOOK3 RPS6KA3 PKN2 FAM114A2 EPC2 RAB2A SPATA6 KCTD16 ZFP3 GJA1 CROT ATAD1 ACSS3 SHE KDSR DLC1 PYGO1 AK7 TAF1B ARIH1 CAMSAP2 SCN7A ZNF644 SEC63 PID1 TMEM168 VPS13B SLC36A4 LIN7A SREK1 GRIK1 GUCY1A2 PTGER3 ONECUT2 MAP3K2 SSBP2 MAP4K5 RNF138 SP4 SENP6 ZNF776 CLCA2 DENND1B SPAST PKHD1L1 ZMYM2 SGMS2 TRHDE APPBP2 UBE3A XPR1 ENTPD5 SYNCRIP CPNE3 ZKSCAN8 ASPN TMEM245 PRTG FAM76B SLAIN2 SUCLA2 MIER3 TICAM2 PPM1B PHIP PDE1C RUNX1T1 NPAS3 SESN3 RAB21 API5 FOXN2 MICU3 BMPR1A BRINP2 SUZ12 HECTD2 ACER3 ZNRF3 IKZF2 RB1CC1 SMIM15 ATL2 DENND4A CGNL1 MAPK9 RAB6A TMBIM4 PRKAA2 MANEA GNG12 HEY1 MIER1 C5orf24 ZMAT3 ALDH6A1 SPRYD7 TMF1 ITPR2 MATN3 ANKRD28 HIPK1 GPATCH2L TDRD15 WDR20 FNIP1 TMEM167A CADM2 FERMT1 FAM126A MIB1 AMD1 SCML1 PDGFA DYNC2H1 MBLAC2 SHPRH INTS2 GPCPD1 XIAP BTBD3 GOLT1B MBTPS2 RBFOX2 AHR ZADH2 MACC1 DDX4 STAU2 CHIC1 CYYR1 SPTLC1 NPHP3 COL6A6 PPP4R2 LCORL S100PBP PDE10A OPRK1 ARMC3 C8orf37 TGFBR3 C14orf132 SEC62 SLC16A9 UBE2N NRP1 SIRT1 PHF6 TOB1 CEP170 INSM1 ITGA6 PIK3CA RC3H2 ARAP2 FRMD4B MCC NEK7 ANGPT2 ZNF713 SOX11 PSME4 UBR2 PEG3 EPB41L4B PTP4A2 ARFGEF1 PSD3 LRRC66 VPS4B EIF2D AZIN1 PPP3CB QKI COBLL1 BCAT1 LPP SP3 NIT2 UNC5C KLF7 SIDT1 HNMT down
## MIR153_5P 0.0011013 0.0125369 -0.3978340 -2.186917 0 979 IGIP TIA1 HMGCLL1 TMEM106B VAMP4 PCMTD1 GAS2 CCNT2 NDFIP2 CREB1 KIAA0408 ORC4 POLR2M TMEM260 KLHL28 EPC1 LTN1 CNTN4 RAB11FIP2 KLHL41 ALDOB CLOCK ZCWPW2 TRIP11 SMAD5 LZTFL1 ERBB4 ERCC6L2 PRPF39 SCAI MYSM1 C8orf34 PTPN4 GPC5 RBM25 ACVR2A STEAP4 CLHC1 ZNF124 CWC22 ZNF33A HS3ST5 GRIK2 PLEKHH2 LIG4 TMEM68 CD24 PIGM NKTR ZRANB3 PTCHD1 SLC4A4 TBCK ZNF10 UBE2K PUM2 PRKRA CHL1 SPOPL IBTK LRRK2 PCSK2 RBAK AASDHPPT SH3GLB1 FAM126B VAPB ANKRD50 PIGA FRMPD4 ZNF277 ALG13 DYNC2LI1 CDC73 ZNF326 MOB1B RASSF8 OMA1 TAB3 C1QTNF7 ZNF506 CDKL1 FBXO36 INO80D EIF4E3 ATP8A1 ZNF22 RPS6KB1 GABRB2 SPATA18 COPS2 ZNF568 PGAP1 NEGR1 PRG4 OMG PCGF5 ATP13A4 PRDM16 RBM39 TOR1AIP2 STXBP5 ZC3H11A SLC16A7 TFB1M RXFP1 ALG6 PIGC TSPAN7 SLC15A5 MDM4 RRM2B PLGLB1 SLC38A2 RAB27B USP3 TMEM233 TCTEX1D1 CNIH1 VAPA NEDD9 IFNAR1 PGR SOGA3 TMED5 BCLAF1 THAP2 ATXN3 VPS36 MTMR7 DUSP19 TC2N PTBP3 CRIPT FCHO2 SEC23IP C12orf40 DICER1 NTRK2 HOOK3 GABPA SLC25A24 RPS6KA3 PCDH11Y ABI2 PTPRD KLHDC10 YTHDF3 FBXO11 CLDN8 DPH6 FAM210B CROT ZBTB41 TBCEL FRYL THUMPD1 IL12B PURB TMEM30A TMEM135 TMCO1 KBTBD3 ZC3H12C RBMX RBMS1 RFESD MOSPD1 PYGO1 DCAF10 ENTPD1 MYO6 SPON1 CLEC19A KRAS FRS2 MYOCD CHML FHL1 PCDH9 TMEM87B TMEM168 NPY1R SLC36A4 TOX3 ARHGAP42 SREK1 VNN1 TMEM144 CCSER2 GUCY1A2 LSAMP ZFP28 NEMF ONECUT2 MAP3K2 MBNL3 ZFR RAB8B C2orf69 CLDND1 NR3C2 ADRA1A RNF138 CEP350 RELN SENP6 SNX25 LRRTM2 TTC8 MARC1 SCEL SNRK KNDC1 YY2 SPAST OSBPL9 TM9SF3 PDS5A RP1 ARF4 RPAP2 TMEM170B RABGAP1L PDE8A AUTS2 USP13 KHDRBS2 PROX1 ZNF512 GPBP1 PDC GATAD1 C11orf16 MTX3 SERINC1 PRTG CLIC6 IPO5 CUL4B OMD PTPRB TMEM33 PHF20L1 PDZD2 SLAIN2 CBLL1 WNT16 TICAM2 ZNF197 ERICH2 PTPN3 DACH1 PHIP CHMP2B PDE1C RUNX1T1 SESN3 AGPS LCOR MSRB3 AP3S1 RGS18 A1CF DCP2 SLC22A15 KCNJ3 NDFIP1 FBXL3 SEMA5A IFIT5 ACER3 PLEKHA1 NCKAP5 ACMSD ZNRF3 ELL2 ATP8B1 CYP2C18 IKZF2 FOXF1 SMIM15 MITF MBTD1 ACSL6 PRKAA2 GHR PHYHIPL UST TNKS MIER1 TAOK1 PREX2 C5orf63 NALCN TMF1 PIKFYVE MMP16 DDHD2 PNPLA8 SP5 GPATCH2L PCMTD2 TMEM167A CADM2 SPINK13 CAV2 NOTUM SHROOM3 GPHN TFAP2D AMD1 EBF2 ATE1 DENND4C DGKI MYO5C SOBP SHPRH INTS2 CHUK GPCPD1 ATL3 MRPS36 ATG14 KLHL32 ZMPSTE24 STAG2 HPGD ARHGAP28 CELF2 CERKL SGMS1 ICK DCP1A RORB DDX6 MGAT4A ZADH2 POU2F1 ATMIN FAM210A ATG5 EPHA3 MFAP3L SDHC PDCD6IP UBE2A CHIC1 MEF2C SGIP1 IGSF10 PPP4R2 BMP3 LRRTM3 DIRAS3 TSEN2 SELE SYNPO2 CTTNBP2NL MAP3K7 VGLL3 PRKAB2 CLDN2 APBB2 AGFG1 CD59 MS4A14 MIPOL1 SLIT3 PIAS1 PPP2R1B RAB11A NRP1 PHF6 TOB1 CHD1 ELOVL2 EXOSC8 APOOL SGCD NEDD4L DENND6A SOX6 CCSER1 NECAP1 CCDC71L VPS29 RBMS2 NMNAT2 CSRNP3 RAB30 ZNF670 GTF2H5 GPR34 RNF11 NAT1 C2CD5 LSM11 ATP1A2 NEK7 APH1B CCNT1 PEX13 PHF14 C4orf33 MTPAP CPSF6 IPO7 SLC35E3 SLC6A14 PSMD5 FRK CBFB FGFR2 SKIL ARHGAP24 WNT3 LRP6 TMEM41B QKI CCDC180 LPCAT2 COBLL1 MFSD6 BCAT1 BTG2 HDAC2 FUT9 KIF5B down
## MIR3671 0.0011601 0.0125369 -0.4065252 -2.184405 0 596 IGIP CD302 TMEM106B PCMTD1 TYW5 CCNT2 ZDHHC21 POLR2M KLHL28 LTN1 CRYZL1 DPP8 SMAD5 PAPOLG ABHD13 ERCC6L2 SCAI C8orf34 PTPN4 ACVR2A BLOC1S5 SMARCAD1 CFTR LMO7 CWC22 HS3ST5 CCZ1B IYD LRP2BP SLC30A7 BNIP2 TMED7 ZBTB21 CNOT6 FNDC3A ZNF451 DMD RC3H1 TRAPPC13 SUCO TMEFF2 NUFIP2 TSPAN12 LYPLAL1 REEP1 CHM ZNF720 SPAG6 UBLCP1 TTC39B LYSMD3 SLC18A2 STXBP5 ZC3H11A SLC16A7 CEACAM5 FSD1L MDM4 PTPN12 ARL5A ELK4 ZNF354C THAP2 REEP3 ATXN3 IPO11 CCNYL1 PTBP3 SMAD2 ABCC4 DNM3 DICER1 SLC25A24 ZC2HC1A MPP5 PKN2 MAP9 FAM114A2 HTR1F RAB2A FBXO11 DLGAP1 DNAJC3 NRG3 ZNF770 GJA1 ZBTB41 ATP11A FAM13B GABRA2 NDUFA5 ZC3H12C LZIC MOSPD1 THAP6 BIRC6 ST3GAL5 FBLN5 PRPF4B AK7 CNOT8 RORA EIF2S1 GPM6A ARHGAP42 LIN7A DMXL1 RASA2 GUCY1A2 MAP3K2 RAB8B SLC38A4 RCBTB1 DENND1B EPHA7 SRRM4 ZMYM2 REPS2 ZCCHC10 ITM2B FMR1 CCDC121 NCKAP1 TSPAN13 PROX1 PCDH20 C14orf39 TDRD3 CPNE3 MTMR9 MTX3 UBXN2B SERINC1 PRTG NIPSNAP3A EXOC5 SPIRE1 TOX WDR17 HSPA13 BMPR2 UFL1 CUL4B TEX10 FGF7 TMEM33 SUCLA2 TIAL1 RAPGEF6 SEMA3D SPRY2 MPP4 PPM1B ARL5B ADAT2 PDE1C EOGT MMRN1 LGALS8 LCOR NMBR API5 MAB21L1 CHORDC1 RIF1 CAST LYPLA1 SUZ12 GCOM1 ACER3 FOXF1 MBTD1 DDX5 ALG10B EIF1AX AFF4 KLF12 MIER1 FAM13C DPP10 TMF1 XKR9 C2orf88 MMP16 TRA2A KIAA1841 TDRD15 CADM2 LHCGR GPHN EDNRA AMD1 TRIM71 POGLUT1 TRPC5 AKAP11 CHUK TET1 IGF1 C15orf41 MID2 AHR PRKACB ZFC3H1 MGAT4A POU2F1 VEZT PARP8 CHIC1 PRRC2C S100PBP SYNRG NAA30 DCX TTC33 MAP3K7 ERAP2 VGLL3 ZIC2 GTF2I BLOC1S6 DTHD1 NRBF2 INSM1 SUPT3H APOOL BACE2 PIK3CA POGK TDRD6 SOX6 NEK1 NECAP1 CCDC71L STX12 SPATA22 PPP2R2A SYT4 NSUN6 ELAVL2 IVNS1ABP CNST ARFGAP3 CNTN1 GLRB KATNAL1 IMPA1 PDHB MCC NR4A3 NEK7 SMC5 TMEM59 CPSF6 HOOK1 CEACAM8 JAG1 CBFB TMEM165 down
## MIR513A_3P_MIR513C_3P 0.0012547 0.0125369 -0.4170618 -2.168805 0 411 TRDMT1 CARF KLHDC1 TMEM106B ZNF678 CDH19 CREB1 ZDHHC21 RANBP3L ANGPTL3 ANGEL2 CTDSPL2 SLC30A6 ABHD13 SCAI ACVR2A SMARCAD1 UGT2B4 ZBTB21 CNOT6 FAM135A UBE2K RC3H1 SH3GLB1 TSNAX NUFIP2 CDC73 ZNF326 MOB1B NCBP1 RASSF8 SLC35F5 KANK4 ZFYVE16 ZNF22 RPS6KB1 CYBRD1 PGAP1 NT5DC1 SLC12A2 APPL1 TOR1AIP2 STXBP5 MED13 RXFP1 FSD1L MDM4 C14orf28 PTP4A1 ARHGAP29 ITCH CALB1 ELK4 RUFY2 CCDC39 RICTOR UEVLD SNX14 ZC2HC1A GAB1 MTM1 YTHDF3 ZBTB41 LEPROT NDUFA5 DCAF10 CUL3 PRPF4B ICA1L NYAP2 ENKUR DR1 CXADR SREK1 LSAMP ZFP28 LRRC3B MBNL3 RAB8B SAR1A BTF3L4 GYPA LAMTOR3 PTEN RNF138 NUDT21 RYBP RELN LIN7C TNPO1 TIPRL SLC2A13 IL6ST RNF146 SPG11 FMR1 SLC6A4 RANBP9 TMEM170B PDE8A GPR180 XPA EPDR1 GPBP1 SPIRE1 HDX TCF12 UFL1 PTPRB TMEM33 PHF20L1 SYPL1 PHIP RNF111 FGFR1OP2 PCDH8 SHANK2 RAPH1 BMX FAM118B LYPLA1 SEMA5A IKZF2 ZBTB8A DRD1 AFF4 PREX2 C5orf24 ALDH6A1 SPRYD7 TMF1 TDRD15 WDR20 CADM2 ZDHHC2 ETNK1 DGKI INTS2 BOLL XIAP UBE2D3 SLC25A46 PRKACB CDK19 SERINC5 TTC28 CHIC1 BAG4 ELF1 SGIP1 PPP4R2 LCORL WASF3 ADAMTSL3 SETD9 NCOA1 FBXO4 VGLL3 AGFG1 PPP2R1B TWF1 FSBP CEACAM1 SLC22A5 MBOAT2 PIK3CA NEDD4L SUV39H2 CSRNP3 SMARCA1 SYT4 GTF2H5 RUNDC3B ELAVL2 CNST STRN FNDC1 MATR3 ABI1 PHF14 CHST9 SKIL LRP6 AZIN1 CNOT6L FUT9 TOP2B SP3 BRMS1L NIPBL ZNF320 KIF13A CACNB4 SEC23A RNF103 NDUFB8 MTF2 TRGC1 ALCAM RPS6KA5 SCAF11 TCEANC2 MAL2 GGCX TRIP12 SLC4A7 NUS1 EFCAB14 LHX8 SPOCK3 LRRC4C LACC1 EEA1 down
## MIR3646 0.0011287 0.0125369 -0.3953152 -2.150597 0 797 GDAP2 UBE2W FGF14 MAPK8 ZDHHC15 CA8 BRWD1 PCMTD1 SLC38A9 SC5D NDFIP2 CREB1 SORBS1 KIAA0408 CGGBP1 ORC4 KLHL28 MAP2K4 CLOCK ZC3H12B CTDSPL2 LZTFL1 PIGN ABHD13 SCAI MYSM1 PTPN4 ACVR2A SMARCAD1 SEC61A2 SOCS4 DNAJC27 SENP7 LRP2BP SLC30A7 SRSF2 TMED7 ZBTB6 NKTR FKTN TFPI USP34 UBE2K ZNF280D ZNF451 SPOPL ZMYND11 GPM6B PCSK2 FAM126B TSNAX ANKRD50 SPIN1 SNX13 CHM RCHY1 INO80D XPO4 LRRC40 PUS10 RNF180 SLC12A2 APPL1 RPGRIP1L SNAP23 KL SLC16A7 FSD1L CCDC144A NRXN1 RAB27B TRMT10A ITCH AHCYL2 ANKRD46 TTC30A FER SOX21 SOGA3 TMED5 SAR1B CTNND2 REEP3 MTMR7 PTBP3 CRIPT DPY19L4 RAB28 NFAT5 RICTOR PDS5B SRI SNTB2 POLK HOOK3 GABPA MTM1 DPP4 BAZ2B YTHDF3 CCDC126 BBS10 EDEM3 TMEM170A CLIC5 FILIP1L DLGAP1 ATAD1 CNTN3 TBCEL ATP11A PURB TMEM135 TMCO1 PIAS2 CUL3 HSD17B6 CA10 CALCRL PANK1 PRPF4B YTHDC2 WDR33 RORA STRBP SCN7A GOLGA8B NPTX1 FRS2 SEC63 GPM6A HELZ CXADR ARHGAP42 LIN7A RASA2 GUCY1A2 LSAMP NEMF ONECUT2 MAP3K2 MBNL3 LIFR FMO2 ZMYM4 CNEP1R1 SLC38A4 SP4 VWA3B LIN7C POT1 COPS8 DENND1B TNPO1 GAPVD1 LIMCH1 PHF3 NIPA1 MYCT1 KLHL20 CRY1 GLMN APPBP2 PDE8A XPR1 MKLN1 RBM4 INTS6 CPNE3 ZKSCAN8 GATAD1 CNR1 ARHGAP12 TMEM245 TOX BMPR2 CUL4B USP8 PHF20L1 MRPL42 TIAL1 ALG5 MIER3 SEMA3D MSANTD2 KRIT1 CNOT2 PHIP NPR3 EEF1E1 ZNF649 IKZF5 NPAS3 RAB21 LCLAT1 LCOR PNISR FOXN2 SSR1 RIF1 DZIP3 RAPH1 GYS2 UBA6 TBC1D32 DPM1 PLCXD3 ZFX PCNP CCDC82 PLEKHA1 ZNRF3 IKZF2 PTER SMCO3 FAM204A CTBS MBTD1 PRKAA2 RAI14 EIF1AX KLF12 CCL16 LATS1 EBF3 ZMAT3 SPEF2 RASGRF2 ZC3H8 KCNA1 HIPK1 SMNDC1 SH3D19 HERC4 CADM2 LHCGR MYT1L POC1B TMEM182 EBF2 AKAP11 STMND1 BOLL MAPRE2 XIAP UBE2D3 HPGD FBXL5 AXIN2 WAC RAD1 EDAR SLC39A10 PRKACB MGAT4A ATG5 DYNC1I2 PDCD6IP MRPL19 WDFY3 SGIP1 BMP3 CCDC125 CD200 PDE10A FAM133B VGLL3 ABCB5 PLAG1 BCAP29 GABRB3 ITPR1 NRP1 PAN3 BCL9 FSBP SLC44A1 RSU1 C16orf87 STX7 LGSN TMX4 APOOL SGCD PIK3CA SOX6 MYCBP2 VPS29 NR2F1 RAB30 KMT2E GPR34 ZNF14 POU3F2 RNF145 SLC12A1 IRS1 IMPAD1 CUL4A MATR3 CSNK1G3 TMEM59 CPSF6 GDAP1 CDK15 EPB41L4B TCEAL7 GRPEL2 SLC30A4 CBFB SKIL ZNF519 NREP CCNK QKI BZW1 C6orf118 LPCAT2 CRLF3 BCAT1 SCAPER HDAC2 CNOT6L GOLGA6L9 SOCS6 USP47 ACTN2 GRID2 ZNF292 FNBP1L down
## MIR5590_3P 0.0012953 0.0125369 -0.4201926 -2.142870 0 334 STX17 CA8 ZBTB37 CCNT2 ETV1 TMX3 MED6 ZC3H12B MAP4K3 ANGEL2 SMAD5 ABHD13 C8orf34 PTPN4 PLEKHA3 PPP6C BNIP2 ZBTB11 DMD RC3H1 ZMYND11 GOPC CLK4 TRIM13 GCC2 ZNF326 ACADSB MLH3 DNAJC25 BMI1 LHFPL3 SLC18A2 STXBP4 SLC12A2 APPL1 CAPN7 SLC15A5 PTP4A1 CEP57L1 SMAD2 NFAT5 FCHO2 PDS5B HOOK3 GAB1 YOD1 VPS54 DLGAP1 ZNF770 LEPROT ZC3H12C TVP23B ZNF624 ALS2 PRPF4B RORA NR1I2 ZNF471 KRAS ATP1B1 CXADR GUCY1A2 ONECUT2 MAP3K2 MBNL3 NR2C1 CNEP1R1 RNF138 NBEA RRP15 DENND1B NFE2L2 KITLG NCKAP1 ZNF587 APPBP2 MKLN1 PIK3C2A CASC1 FHIT SPAG9 MTMR10 SYNJ1 ZCCHC14 UFL1 MCMDC2 LDB2 NPAT FGFR1OP2 CSMD3 MOSPD2 MAGI2 BMPR1A FBXL3 EPAS1 IFIT5 ACER3 RB1CC1 SACS ACSL6 PHYHIPL AFF4 GNG12 SLAIN1 NUP133 TRIM23 SOX7 TCF21 ANKRD28 STK38L HIPK1 CADM2 ZDHHC2 CAV2 FAM126A ANGPTL5 GDNF AQP11 IGF1 MRPS36 RAD50 MID2 SGMS1 AHR ICK CDK19 DYNC1I2 FAM155A PDCD6IP UBE2A GPR155 UBE2D1 DNAJC7 MTR PRPF40A ERH VGLL3 ABCB5 ADAM20 S1PR1 TVP23C IGFL1 VMP1 ZNF454 PIK3CA NEDD4L CCSER1 down
## MIR4735_5P 0.0013966 0.0125369 -0.4495586 -2.132451 0 174 BRWD1 TSPAN2 CREB1 SHH MAP2K4 DNAJB14 SCAI SLC4A4 RB1 PUM2 RC3H1 SPOPL PCSK2 FAM126B TMEFF2 RASSF8 SF3B1 PTGS2 INO80D ZNF382 SEC24B ELK4 SOX21 CPEB2 FCHO2 HOOK3 PKN2 EPC2 ARHGEF33 ZC3H12C DCAF10 ENKUR AQP4 GOLGA4 MBNL3 NR2C1 VWA3B IGFBPL1 RCBTB1 VKORC1L1 STYX AUTS2 SRPX OMD PHF20L1 SLAIN2 TRMT5 SPRY2 AGPS LCOR A1CF DCP2 RAB6A UACA DPP10 RBL2 ZDHHC17 CNTD1 CADM2 STAG2 CELF2 AHR PPP4R2 CYSLTR1 EED ZFP14 SYNE2 SIX2 CSRNP3 EFHB SLIT2 C2orf66 ANKRD13C NR4A3 TMEM59 ZNF519 QKI CNOT6L FUT9 EFEMP1 GRID2 TP53BP2 PCDH10 SUSD5 YIPF6 FZD3 RABEP1 down
## MIR4762_3P 0.0013316 0.0125369 -0.4286164 -2.124063 0 254 FREM2 MAPK8 MBD5 STAM2 CLOCK KCNJ16 SLC30A6 SCAI RBM25 SOCS4 N6AMT1 TRIQK BROX POLR3F RC3H1 SPOPL SH3GLB1 FAM216B NUFIP2 TSPAN12 MOB1B C9orf72 DNAJC25 LHFPL3 STXBP5 SLC16A7 MZT1 DBT ITCH RTKN2 FER JMJD1C CEP57L1 PTBP3 CRIPT NFAT5 GTF2A1 AHCTF1 SNTB2 RPS6KA3 PCDH11Y MAP9 SRBD1 PTPRD GORAB BAG5 ZBTB41 SHE TMEM135 ANKRD49 NYAP2 MYOCD GLRA4 ZFP28 ZNF24 DENND1B PDE8B TSEN15 USP12 TRHDE UBXN2B SMG7 TRMT1L TMEM47 SYNJ1 TCF12 PHF20L1 MRPL42 NPAS3 AGPS RGS18 GALNT7 ZFX LPGAT1 IKZF2 RB1CC1 ZNF302 ATL2 PRKAA2 ZNF208 ZDHHC17 HSD17B11 UNC13C GDPD1 TMEM167A ZDHHC2 SHROOM3 CNOT7 TRPC5 ATL3 STAG2 FBXL5 RBFOX2 DDX6 POU2F1 ZNF480 SHC4 ASAH1 NABP1 SGIP1 down
## MIR142_5P 0.0012920 0.0125369 -0.4157353 -2.123219 0 331 STX17 CA8 ZBTB37 ETV1 TMX3 MED6 ZC3H12B MAP4K3 ANGEL2 SMAD5 C8orf34 PTPN4 PLEKHA3 PPP6C BNIP2 ZBTB11 DMD RC3H1 ZMYND11 GOPC CLK4 TRIM13 GCC2 ZNF326 ACADSB MLH3 DNAJC25 BMI1 LHFPL3 SLC18A2 STXBP4 SLC12A2 APPL1 CAPN7 SLC15A5 PTP4A1 CEP57L1 SMAD2 NFAT5 FCHO2 PDS5B HOOK3 GAB1 YOD1 VPS54 DLGAP1 ZNF770 LEPROT ZC3H12C TVP23B ZNF624 ALS2 PRPF4B RORA NR1I2 ZNF471 KRAS ATP1B1 CXADR GUCY1A2 ONECUT2 MAP3K2 MBNL3 NR2C1 CNEP1R1 RNF138 NBEA RRP15 DENND1B NFE2L2 KITLG NCKAP1 ZNF587 APPBP2 MKLN1 PIK3C2A CASC1 FHIT SPAG9 MTMR10 SYNJ1 ZCCHC14 UFL1 MCMDC2 LDB2 NPAT FGFR1OP2 CSMD3 MOSPD2 MAGI2 BMPR1A FBXL3 EPAS1 IFIT5 ACER3 RB1CC1 SACS ACSL6 PHYHIPL AFF4 GNG12 SLAIN1 NUP133 TRIM23 SOX7 TCF21 ANKRD28 STK38L HIPK1 CADM2 ZDHHC2 CAV2 FAM126A ANGPTL5 GDNF AQP11 IGF1 MRPS36 RAD50 MID2 SGMS1 AHR ICK CDK19 DYNC1I2 FAM155A PDCD6IP UBE2A GPR155 UBE2D1 DNAJC7 MTR PRPF40A ERH VGLL3 ABCB5 ADAM20 S1PR1 TVP23C IGFL1 VMP1 ZNF454 PIK3CA NEDD4L CCSER1 DIAPH2 CLIC4 CNTN1 ZNF239 CUL4A ANGPT2 TNS1 CYLD DUSP18 SLC30A4 LMX1A SRSF6 down
## MIR579_3P 0.0012034 0.0125369 -0.4016751 -2.119451 0 470 ZC3H6 NDFIP2 SORBS1 SWT1 POLR2M DPP8 ANGEL2 CTDSPL2 MAMDC2 DNAJB14 PAPOLG TMEM220 PLEKHA3 ACVR2A NKTR FNDC3A PTCHD1 SLC4A4 GPM6B GOPC LRRK2 RAB22A ROBO2 SRP19 FAM98B SPA17 CDC73 ZNF326 MOB1B CHM APC TTC17 OSBPL6 LRRC19 ATP8A1 GABRB2 XPO4 PHKB OMG STXBP5 SLC16A7 CAPN7 DBT ARL5A SEC24B TMEM233 RUFY2 PARM1 CEP57L1 SPTLC3 AHCTF1 SNTB2 CCNC HSD17B12 NTRK2 HOOK3 GABPA RPS6KA3 ABI2 PKN2 SRBD1 YOD1 YTHDF3 CLIC5 CLDN8 KCTD16 GJA1 ATAD1 FRYL ZNF655 DNAI2 TMEM135 PIAS2 PYGO1 DCAF10 MYO6 PANK1 PRPF4B YTHDC2 WDR89 ERP44 CDH10 SMIM8 GUCY1A2 LSAMP AQP4 PTGER3 MBNL3 MAP4K5 GYPA ZMYM4 SENP6 LRRTM2 STMN2 IL6ST PRICKLE2 LAMP3 GPR180 RIOK2 GPBP1 SERINC1 PRTG FAM76B SPIRE1 UFL1 CUL4B PHF20L1 MAATS1 SYPL1 SULT1B1 PHIP ANKRD10 IKZF5 NPAS3 MMRN1 AGPS OGT SLC25A16 PLAC8 COL4A3 RIF1 DCP2 EIF3J BMPR1A PHACTR2 DIP2C NAALADL2 PTCHD4 ZFX GCOM1 NCKAP5 ZNRF3 ELL2 ZNF347 SMIM15 DENND4A MBTD1 ACSL6 KLF12 TAOK1 RASGRF2 TMF1 C2orf88 CTNNAL1 SMIM14 KLF5 MCTS1 PNPLA8 FNIP1 CADM2 CAV2 SHROOM3 ETNK1 GPHN POC1B CMTM4 ATE1 TMEM45A DENND4C SOBP STAG2 GIPC2 ARHGAP28 DLG2 MBTPS2 FAM210A EPHA3 SGIP1 SHC3 MED4 LRRTM3 METTL14 CTTNBP2NL MAP3K7 ERAP2 LACTB2 SETX VGLL3 DSCAML1 APBB2 AGFG1 ITPR1 GNAQ SIRT1 MEGF11 MAP3K13 KCNH8 AK3 ZFP14 TMX4 MBOAT2 PIK3CA NEDD4L CCSER1 CAPZA1 C5orf49 NSUN6 GPR34 POU3F2 ZBTB34 C2CD5 AP1S2 LSM11 NR4A3 NEK7 PSMD12 PCDH18 ZNF713 IPO7 SLC6A11 SKIL DOCK1 LRP6 QKI BZW1 COBLL1 MFSD6 F5 FUT9 KIF5B ACTN2 KLF7 HNMT RAP1A CD2AP ARRB1 CCAR1 HEY2 TMEM99 CACNB4 PPP2R3A SLC10A2 ALCAM NPY5R HAS2 YIPF6 FZD3 down
## MIR6739_3P 0.0013850 0.0125369 -0.4455043 -2.119206 0 178 SOX14 CCDC181 TCAIM CA8 RIMS1 TSPAN2 DNAL1 ERBB4 ERCC6L2 PLEKHA3 PBRM1 SLC4A4 PDE4D GPM6B FAM122A ANKRD50 CEPT1 UFM1 ZNF385B KCNJ13 ELK4 BRINP1 YOD1 MED31 EIF2S1 DMXL1 EMB MAP3K2 PAQR3 MBNL3 SLCO4C1 NBEA LRIT3 COG2 CSNK2A1 KLHL20 ZC3H14 UBE3A SPAG9 GREM2 BMPR2 TCF12 ZFP69 SEMA3D INSIG2 COL4A3 CAST DIP2C NAALADL2 FOXF1 UST PREX2 ITPR2 KLF5 SLC10A7 GPHN POC1B SYTL5 ZNF470 DUSP6 DLG2 ZIC5 FZD8 MID2 CHIC1 NXT2 PDE10A SOCS5 SETX SERAC1 down
## MIR664B_3P 0.0012107 0.0125369 -0.4018034 -2.114777 0 465 ZC3H6 NDFIP2 SORBS1 SWT1 POLR2M DPP8 ANGEL2 CTDSPL2 MAMDC2 DNAJB14 PAPOLG TMEM220 PLEKHA3 ACVR2A NKTR FNDC3A PTCHD1 SLC4A4 GPM6B GOPC LRRK2 RAB22A ROBO2 SRP19 FAM98B SPA17 CDC73 ZNF326 MOB1B CHM APC TTC17 OSBPL6 LRRC19 ATP8A1 GABRB2 PHKB OMG STXBP5 SLC16A7 CAPN7 DBT ARL5A RAB27B SEC24B TMEM233 RUFY2 PARM1 CEP57L1 SPTLC3 AHCTF1 SNTB2 CCNC HSD17B12 NTRK2 HOOK3 GABPA RPS6KA3 ABI2 PKN2 SRBD1 YOD1 YTHDF3 CLIC5 CLDN8 GJA1 ATAD1 FRYL ZNF655 DNAI2 TMEM135 PIAS2 PYGO1 DCAF10 MYO6 PANK1 PRPF4B YTHDC2 WDR89 ERP44 CDH10 SMIM8 GUCY1A2 LSAMP AQP4 PTGER3 MBNL3 MAP4K5 GYPA ZMYM4 SENP6 LRRTM2 STMN2 IL6ST PRICKLE2 LAMP3 GPR180 RIOK2 GPBP1 SERINC1 PRTG FAM76B SPIRE1 UFL1 CUL4B PHF20L1 MAATS1 SYPL1 SULT1B1 PHIP ANKRD10 IKZF5 NPAS3 MMRN1 OGT SLC25A16 PLAC8 COL4A3 RIF1 DCP2 EIF3J BMPR1A PHACTR2 DIP2C NAALADL2 PTCHD4 ZFX GCOM1 NCKAP5 ZNRF3 ELL2 ZNF347 SMIM15 DENND4A MBTD1 ACSL6 KLF12 TAOK1 RASGRF2 TMF1 C2orf88 CTNNAL1 SMIM14 KLF5 MCTS1 PNPLA8 FNIP1 CADM2 CAV2 SHROOM3 ETNK1 GPHN POC1B CMTM4 ATE1 TMEM45A DENND4C SOBP STAG2 GIPC2 ARHGAP28 DLG2 MBTPS2 FAM210A EPHA3 SGIP1 SHC3 MED4 LRRTM3 METTL14 CTTNBP2NL MAP3K7 ERAP2 LACTB2 SETX VGLL3 DSCAML1 APBB2 AGFG1 ITPR1 GNAQ SIRT1 MEGF11 MAP3K13 KCNH8 AK3 ZFP14 TMX4 MBOAT2 PIK3CA NEDD4L CCSER1 CAPZA1 C5orf49 NSUN6 GPR34 POU3F2 ZBTB34 C2CD5 AP1S2 LSM11 NR4A3 PSMD12 PCDH18 ZNF713 IPO7 SLC6A11 SKIL DOCK1 LRP6 QKI BZW1 COBLL1 MFSD6 F5 FUT9 KIF5B ACTN2 KLF7 HNMT RAP1A CD2AP ARRB1 CCAR1 HEY2 TMEM99 CACNB4 PPP2R3A SLC10A2 ALCAM NPY5R HAS2 YIPF6 FZD3 down
## MIR32_3P 0.0013158 0.0125369 -0.4148184 -2.103618 0 310 TRDMT1 ZC3H6 MBNL2 PTAR1 BRWD1 NDFIP2 ZDHHC21 PPARGC1A EPC1 ABHD13 SCAI PTPN4 GPC5 ACVR2A NDNF SENP7 PPP6C PAPOLA STRADB INO80D EIF4E3 FBXO28 DAAM1 CD58 STXBP5 MED13 PTPN12 ARL5A CNIH1 HEATR5A HOOK3 GABPA MTM1 YOD1 SYNJ2BP NPHP1 FAM210B RNF141 TAPT1 KBTBD3 NDUFA5 KIAA1143 YTHDC2 ARIH1 RORA KRAS ATP1B1 SLC36A4 CXADR ONECUT2 NR3C2 NEK10 CNEP1R1 CMPK1 VWA3B TNPO1 PDE8B TIPRL FAM8A1 TBC1D23 USP12 MKLN1 CPNE3 SEPSECS SPIRE1 USP8 NHLRC2 TRMT5 GUF1 RAB21 CNKSR2 TBC1D32 PDE3A NAALADL2 ACER3 MMAA ANK3 ADAMTS6 GK NDUFS1 PREX2 DPP10 ZDHHC17 ANKRD28 KLF5 SMNDC1 CAV2 TYW3 CNOT7 PCM1 ARHGEF28 ATP11B C15orf41 USP24 STAG2 CELF2 SGMS1 AHR SERPINB4 TTC28 SGIP1 PPP4R2 LRRTM3 CCDC125 NAA30 PDE10A L3HYPDH PRPF40A MNX1 SERPINB3 TMEM108 PIAS1 TWF1 STX7 MYCBP2 GNPTAB PPP2R2A SLIT2 IRS1 STRN NR4A3 SMC5 ARHGEF3 TM6SF1 HTR2A SKIL NPAS2 SRSF6 FERMT2 QKI SEC24D CNOT6L FUT9 KIF5B SOCS6 EFEMP1 ACTN2 down
## MIR7856_5P 0.0012739 0.0125369 -0.4045611 -2.088659 0 376 CCNJ ZDHHC21 ETV1 KIAA0408 TMEM260 KLHL28 CLOCK CTDSPL2 SMAD5 SCAI PTPN4 ACVR2A KLHL23 VPS13C RCOR3 SRSF2 TTC21B ARPP19 ZBTB6 BROX FNDC3A PTCHD1 SLC4A4 RC3H1 SPOPL RBAK THOC2 SPIN1 NUFIP2 SNX13 ROBO2 VMA21 CDC73 MOB1B GLCE TRAPPC2 BBIP1 OSBPL6 UBLCP1 LRRC19 INO80D DNAJC25 COPS2 NRXN3 RNF2 ZNF568 NEGR1 SLC12A2 DAAM1 FSD1L TMTC4 RRM2B RTKN2 FAM172A THAP2 RICTOR SRI DICER1 NTRK2 PCDH11Y YOD1 SCN1A ZBTB41 ATP11A PANK3 KRAS AIDA MASP2 EIF2S1 SREK1 DMXL1 GUCY1A2 MAP3K2 PAQR3 KLB RYR3 CLUL1 DOCK7 TIPRL EPHA7 SULT1C4 ITM2B REV1 MKLN1 PIK3C2A SRPX REV3L ARHGAP12 HDX BMPR2 ZCCHC14 TTLL7 RAPGEF6 ING3 DDX31 DACH1 IDE PNISR A1CF CNKSR2 OGT GPR22 MAB21L1 SSR1 RIF1 MOSPD2 PHACTR2 SUZ12 DNAH6 ELL2 DPY19L3 PRKAA2 DRD1 UNC50 OARD1 MCTS1 KIAA1841 SLC10A7 ZDHHC2 SHROOM3 XIAP GIPC2 MBTPS2 THRB MGAT4A EPHA3 MFAP3L UBE2A BAG4 TGFBR3 C14orf132 RWDD2B TMEM108 GTF2I NANP SIRT1 TWF1 PTPN13 ZBTB43 TRAF6 TMX4 LGALSL SGCD WDR26 MBOAT2 ZRANB1 RAB30 POU3F2 IRS1 CNTN1 GLRB ZYG11B CPSF6 ARL8B HOOK1 LRIF1 METTL8 LPAR4 LRP6 PPP3CB DCDC1 BZW1 COBLL1 DHX40 F5 PPP1CB SP3 NEXN down
## MIR548N 0.0011834 0.0125369 -0.3901889 -2.083279 0 568 ZC3H6 RHOT1 UBE2W SMARCE1 ZDHHC15 CCNJ CA8 B3GALT2 BRWD1 CDKL5 RIMS1 SC5D CCNT2 STOML3 ZDHHC21 KLHL28 DNAL1 FAM221A MAP4K3 DPP8 PRPF39 SCAI DMTF1 ACVR2A SEC61A2 VPS13C APLF SLC30A7 PAPOLA ARPP19 ZBTB6 TRIQK ZRANB3 SLC4A4 FAM135A USP44 PDE4D RC3H1 PPIP5K2 GPM6B UBR3 TSNAX TTC13 C5orf51 TMEFF2 EPB41L5 ROBO2 ZNF326 MOB1B OMA1 C9orf72 TAB3 DIS3 ANGPTL1 BMI1 RNF2 UFM1 PGAP1 NEGR1 UBE2B DAAM1 APPL1 RPGRIP1L DESI2 STXBP5 GPD1L MZT1 CLASP2 AQP3 NRXN1 SLC38A2 RAB27B C14orf28 ARHGAP29 ZNF493 TTC30A EMCN RUFY2 DCT SAR1B RGS7BP REEP3 PTBP3 NFAT5 ATF6 DUS4L HOOK3 GABPA PCDH11Y PKN2 CLCC1 BBS10 ECHDC1 ZBTB41 CCT6B THAP6 PTGR2 ARIH1 STRBP KRAS SKIDA1 LANCL1 GPM6A HELZ TOX3 CXADR SREK1 MAP3K2 ZFR FMO2 MAP4K5 LAMTOR3 CPS1 RYBP LIN7C SERINC3 ZNF681 TM9SF3 ZMYM2 ABCB11 CSNK2A1 USP12 KITLG APPBP2 RABGAP1L AUTS2 ANAPC1 ABI3BP PCDH20 ABCA8 INTS6 SYNCRIP REV3L USP6NL EXOC5 FAM76B EXPH5 BMPR2 C2orf73 SLAIN2 MIER3 KRIT1 ANKRD10 ZNF649 C4orf19 AKAP7 FAM200B PNISR ZFP91 ZNF106 MICU3 NAALADL2 TMEM181 EXOC6B ELL2 IKZF2 FOXF1 ALG10B SACS PRKAA2 GNG12 TAOK1 SLAIN1 LATS1 C5orf24 BIVM C11orf87 CCDC179 ERLEC1 TAL1 SCML1 CCP110 GPR137C SPHKAP SOBP SIM2 BOLL STAG2 UBE2D3 RBFOX2 PRKACB MGAT4A UNC45B SAV1 DYNC1I2 VEZT PDCD6IP ZKSCAN7 STAU2 CHIC1 NABP1 MEF2C SGIP1 NCOR1 CCNG1 S100PBP BMP3 EMP1 NAA30 FMN2 DCUN1D1 CYSLTR1 FAM133B VGLL3 PLAG1 AGFG1 GTF2I PRKAA1 GPR171 MEGF11 TVP23C TWF1 CHD1 NUP54 AK3 INSM1 WDR26 MBOAT2 DENND6A PPEF2 SOX6 CCSER1 GNPTAB CSRNP3 SH3BGRL GLIPR1 TIAM2 IVNS1ABP ZBTB34 TMOD2 IMPAD1 CNTN1 KATNAL1 HAUS2 NEK7 MATR3 PEX13 SMC5 C4orf33 ATP10B SEC22B DIRC1 CHST9 SKIL LMX1A SRSF6 QKI ZIK1 LPP CNOT6L SOCS6 CTNNA3 RPRD1A CD2AP FUBP1 CXCL11 AADAT PCDH10 down
## MIR195_3P 0.0013550 0.0125369 -0.4271129 -2.077124 0 214 FGF14 MBD5 ZNF678 NBEAL1 KIAA0408 CNTN4 ALDOB CLOCK PBRM1 IYD TMED7 THAP9 BROX ZNF280D RC3H1 SPOPL FAM126B TMEM161B MOB1B OMA1 USP16 FBXO28 NEGR1 AP4E1 TSPAN19 UBE2B ZNF117 FSD1L CLASP2 NCAM2 PTPN12 SLC38A2 CPEB2 SOGA3 CTNND2 DPY19L4 MPP5 BBS10 ATAD1 COG6 CNTN3 TCTEX1D2 SOAT1 PIAS2 RORA CHML MTMR6 SNRK ZNF681 DENND1B TNPO1 ZNF714 SLC2A13 PEX5L ZCCHC10 BAHCC1 CNR1 SEPSECS UFL1 MIER3 KERA MARC2 PLCXD3 ZFX CCDC82 ACER3 RB1CC1 PTER RAB6A TMBIM4 RAI14 PREX2 GPATCH2 BTG3 CADM2 INTU AGL RPP30 BTBD8 ICK CHIC1 SGIP1 CD200 PLAG1 MIPOL1 PRKAA1 NAT2 RGS5 PTPN13 C16orf87 TLK1 ARAP2 OLA1 STRN SHQ1 ANKRD13C IPO7 FRK ARFGEF1 down
## MIR12124 0.0013316 0.0125369 -0.4107531 -2.077043 0 303 GDAP2 TMEM106B CA8 SESTD1 ORC4 CNTN4 TRIP11 SCAI LRP2 SOCS4 SLC30A7 BNIP2 ARPP19 CNOT6 ABCA13 KPNA3 SOS1 DYNLT3 CAB39L PPIP5K2 FAM126B FAM122A NUFIP2 SNX13 UPRT ZBTB1 TRAPPC2 ASH1L LRRC19 INO80D GABRB2 UBE2B KL SAR1B ZNF430 PTBP3 SMAD2 GTF2A1 DNM3 RICTOR PDZRN4 DUS4L HOOK3 BAZ2B FBXO11 KIF3A EVI5 ZBTB41 TAPT1 PURB TMEM30A GABRA2 MORC3 HECW2 BCKDHB KRAS AIDA SEC63 RAB3GAP2 TOX3 DDX52 NEMF ZNF24 SAR1A BTF3L4 TUB PEX1 BRAF RRP15 TM9SF3 ELMOD2 HTR2B LAMP3 LMBRD2 IRAK1BP1 ZNF772 CUL4B FAT4 RBM12 PHIP ASF1A EOGT A1CF ACER3 PTER ADAMTS6 CTBS TFCP2L1 ATP10D KLF12 SOX7 TRAPPC11 PIKFYVE GRIA3 SHROOM3 COL4A4 ITGA8 USP24 PSMG2 AGL FBXL5 CERKL RAD1 SGMS1 PRKACB MGAT4A ATG5 down
## MIR4699_3P 0.0012136 0.0125369 -0.3948364 -2.072718 0 449 ALG11 RHOT1 KATNBL1 B3GALT2 TYW5 DCAF17 SESTD1 TM9SF2 CGGBP1 RAB11FIP2 MAMDC2 ERBB4 SACM1L ABHD13 SCAI PTPN4 TMEM220 FGF9 RBM25 IYD RCOR3 ARPP19 NKTR UBE2K LRRK2 FAM126B UBR3 RAB14 NUFIP2 NCBP1 APC INO80D RALGAPB GABRB2 TUBGCP3 NEGR1 RBM39 STXBP5 SLC38A2 PTP4A1 KCTD4 RGS7BP IREB2 FCHO2 RICTOR AHCTF1 DICER1 PCDH11Y GAB1 PKN2 ITGB3BP EDEM3 MFAP3 FILIP1L CASD1 ZNF33B DLC1 KBTBD3 ZC3H12C SRP9 CALCRL WDR89 RORA STRBP TXNL1 PIP5K1B PCDH9 CDH10 OCLN GUCY1A2 MAP3K2 PAQR3 MBNL3 C1orf21 CNEP1R1 CMPK1 ADRA1A CEP350 STMN2 C2orf49 COG2 VKORC1L1 PHF3 NIPA1 TBC1D23 ZMYM2 USP12 CRY1 KLF3 TMEM170B N4BP2L1 CDH6 CCPG1 INTS6 CACNB2 TOX EXPH5 ZCCHC14 PTPRB TMEM33 TIAL1 ING3 LRIG2 BMP6 ZNF197 DACH1 PDE1C NPAT AP3S1 DNAH10 A1CF PLAC8 SUZ12 RAD17 HECTD2 PCNP IFIT5 PLEKHA1 ZNF257 LARP7 FOXJ3 ALG10B PTPRM UNC50 B3GALT1 TSGA10 PIKFYVE DDHD2 KLF5 RAPGEF4 GRIA3 ETNK1 FAM126A CNOT7 INTS2 ITGA8 DUSP6 HNF1B GOLT1B DLG2 MPP7 ADRA2A RAB27A ICK CRLS1 CDK19 ATMIN HSD17B13 PARP8 CHIC1 ASAH1 ELF1 SGIP1 NCOR1 BMP3 ADAMTSL3 EMP1 DCUN1D1 OPRK1 SLC27A2 UBE2V2 TGFB2 PRKD3 PRPF40A APBB2 ZIC2 ITPR1 GNAQ PAN3 SYT15 PTPN13 CYTH3 STX12 RASA1 FASTKD5 ELAVL2 VIP LONRF3 PDE1A ZBTB34 STRN LGR5 ATP1A2 ANGPT2 CSNK1G3 DNAJC10 CPSF6 ARL8B HOOK1 SLC35D2 NF1 PSD3 NAP1L3 CBFB FGFR2 SKIL LRP6 TMEM41B AZIN1 DHX40 CNOT6L FUT9 SVIP FBXO3 PEX2 SLC1A1 P2RY14 RFX7 down
## MIR6507_5P 0.0013106 0.0125369 -0.4079707 -2.070819 0 311 KLHDC1 PTAR1 PCMTD1 ZDHHC21 RANBP3L KIAA0408 KLHL28 MFSD8 ORC2 SCAI MYSM1 ARPP19 RBM26 CD55 CLK4 FAM126B EPB41L5 NUFIP2 TSPAN12 ZBTB1 SLC35F5 CEPT1 TUBGCP3 AP4E1 RNF180 PCGF5 PACRGL APPL1 STXBP5 ZC3H11A ZNF117 RAB27B TRMT10A AHCYL2 TMEM233 CNIH1 TTC30A SOGA3 ZNF354C COPG2 NFAT5 RICTOR HOOK3 MPP5 RPS6KA3 DOCK9 USP45 DNAJC3 ZBTB41 COG6 CNTN3 FAR1 MYO6 ARIH1 CAMSAP2 DRAM1 SLC36A4 PDE5A CXADR GRIK1 MAP3K2 PTEN ADRA1A LIN7C BRAF PRDM5 VKORC1L1 SPAST GAPVD1 NOX1 FAM8A1 OSBPL9 MYCT1 REPS2 MKLN1 ASCC3 SLC5A8 SMG7 CDC40 PGGT1B BMPR2 SLAIN2 SUCLA2 PPM1B ARL5B RALGAPA1 IL2 A1CF MICU3 RIF1 CAST HECTD2 ANK3 UGT1A10 ALG10B PTPRM PRKAA2 WARS2 EIF1AX SPRYD7 MCTS1 WDR20 SHROOM3 CCP110 AGL XIAP AMMECR1 AHR ZADH2 QRFPR STAU2 CHIC1 CCNG1 LRRTM3 NCOA1 FAM107B APBB2 ZNF43 SYT15 ROCK2 down
## MIR1252_3P 0.0013228 0.0125369 -0.4120720 -2.070443 0 281 STX17 MBNL2 VAMP4 BRWD1 NDFIP2 CREB1 CGGBP1 KLHL28 CLOCK ZCWPW2 SMAD5 MYSM1 BNIP2 TMED7 GOPC ZNF529 FAM126B SPIN1 FRMPD4 UPRT LRRC40 RNF2 MFAP5 PGAP1 ZNF621 SLC12A2 SNAP23 ITGA1 GPD1L FSD1L RRM2B ITCH JMJD1C CCDC39 HOOK3 DPP4 YTHDF3 ECHDC1 ODF2L EVI5 PIAS2 ZNF91 THAP6 CUL3 ZNF624 PRPF4B STRBP CHML ZNF644 OGN CDH10 GPM6A CXADR LIN7A MBNL3 RAB8B CNEP1R1 LIN7C LRRTM2 UBA3 SLC2A13 CSNK2A1 KLHL20 KITLG GLMN ABI3BP TPK1 GPBP1 SPAG9 TOX BMPR2 CUL4B FAT4 MRPL42 SEMA3D EOGT IKZF5 SSR1 CSMD3 NUMB HECTD2 NT5C1B MAPK9 ACSL6 GULP1 GLO1 EIF1AX ZMAT3 CCDC179 PIKFYVE MCTS1 GDPD1 CADM2 TMEM182 GDNF AKAP11 INTS2 BOLL AGL EDAR SMAD9 WDFY3 SGIP1 BMP3 DCX CYSLTR1 down
## MIR16_2_3P 0.0013423 0.0125369 -0.4245712 -2.068760 0 213 FGF14 MBD5 ZNF678 NBEAL1 KIAA0408 CNTN4 ALDOB CLOCK PBRM1 IYD TMED7 THAP9 BROX ZNF280D RC3H1 SPOPL FAM126B TMEM161B MOB1B OMA1 USP16 FBXO28 NEGR1 AP4E1 TSPAN19 UBE2B ZNF117 FSD1L CLASP2 NCAM2 PTPN12 CPEB2 SOGA3 CTNND2 DPY19L4 MPP5 BBS10 ATAD1 COG6 CNTN3 TCTEX1D2 SOAT1 PIAS2 RORA CHML MTMR6 SNRK ZNF681 DENND1B TNPO1 ZNF714 SLC2A13 PEX5L ZCCHC10 BAHCC1 CNR1 SEPSECS UFL1 MIER3 KERA MARC2 PLCXD3 ZFX CCDC82 ACER3 RB1CC1 PTER RAB6A TMBIM4 RAI14 PREX2 GPATCH2 BTG3 CADM2 INTU AGL RPP30 BTBD8 ICK CHIC1 SGIP1 CD200 PLAG1 MIPOL1 PRKAA1 NAT2 RGS5 PTPN13 C16orf87 TLK1 ARAP2 OLA1 STRN SHQ1 ANKRD13C IPO7 FRK ARFGEF1 down
## MIR380_3P 0.0013405 0.0125369 -0.4238933 -2.067000 0 217 GDAP2 CA8 BRWD1 ZNF678 LTN1 CNTN4 RAB11FIP2 ANGEL2 ERCC6L2 SOSTDC1 CCDC68 RCOR3 RBM26 FNDC3A RC3H1 PPIP5K2 CHD9 WDR78 ABO MOB1B ZNF720 ZFYVE16 FBXO36 STXBP5 SLC16A7 MZT1 FSHR NRXN1 PGR HEATR5A KCNK10 EIF4E GABPA YTHDF3 DOCK9 CNTN3 KDSR NDUFA5 RORA TOX3 GRM6 GUCY1A2 GYPA NME7 SCEL TNPO1 UFSP2 SPAST STYX ZMYM2 SLC2A13 SHOC2 THSD4 TSTD3 STON1 ASCC3 UFL1 TMEM33 PHIP ZNF649 RAB21 MS4A7 SUZ12 ITFG1 MMAA DPY19L3 SMIM15 PTER DDX5 THUMPD3 PRKAA2 MANEA GPATCH2 HYDIN PROS1 SLC10A7 SHPRH C15orf41 MBTPS2 MID2 AHR PRKACB SDHC ASAH1 PPP4R2 LRRTM3 down
fgsea_plot(fgsea_res$res_c4, pathways_title='C4 cancer', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------ ---------- --------- ---------- --------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## MORF_NME2 0.0035587 0.012315 0.6588520 3.328078 0 141 UBC AP2M1 MYL6 TBCB NDUFA1 OAZ1 COX5B CFL1 MRPL23 ALDOA BANF1 ARF5 TSR3 GANAB POLR2H SSNA1 HMGN2 URM1 C9orf16 TUBA1B FAU CCT7 PFN1 COX6B1 RPLP0 SPAG7 CYC1 ACTB COX4I1 COX8A OTUB1 PSMD8 STOML2 UBB ENO1 HUWE1 NME1 RPS12 PSMB4 PDAP1 RAN DNPEP CALR RPL13 UBE2I GNAS RPL19 COPS6 LYPLA2 RPL38 LDHA RPS16 RPL27A RALY COX6A1 RPL35 SNRPB RPLP2 PSMB1 UBA1 NDUFA2 EEF1D RPL12 TMEM147 RPL18 RPS24 HDGF ATP6V1F RPS3 EEF2 RPS6 COX7C RPL13A PSMC1 NPM1 RPL18A RPS14 RPL11 RPL36AL NACA PPIA CANX PUF60 HSP90AB1 EIF4A1 PABPC1 RPL23A RPS20 SUMO3 HSPD1 RPL8 SRP14 RPS27A up
## MORF_MAP2K2 0.0034965 0.012315 0.6630411 3.259012 0 117 GPI SRSF9 AP2S1 SLC3A2 AP2M1 RPN1 DGKZ EIF3K COX5B BANF1 NDUFS3 NDUFV1 TMED9 GANAB PPP2R1A SF3B2 RUVBL2 TBL3 PARK7 CCT7 ERP29 IDH3B GPX4 NONO CYC1 SOD1 PPM1G POLR2I FIBP NDUFC1 SNRPA LSM4 COX8A UBE2S PSMD8 TRIM28 RANGAP1 CTDNEP1 VDAC2 DDX49 AP3D1 MAP2K2 HNRNPAB DDOST SLC4A2 EIF3I COPE ANAPC5 PCMT1 KHDRBS1 NDUFS5 HADHA DCTN2 CS HNRNPUL1 IMPDH1 HAX1 TRAPPC3 AFG3L2 GNB1 SDHA CCT5 TUFM SET RAD23A GNB2 up
## MORF_ANP32B 0.0035971 0.012315 0.6162297 3.219793 0 183 SRSF9 FBL COMMD4 AP2M1 HMGB2 EIF3K NUDT1 NDUFA1 COX5B BANF1 NDUFS3 CNBP NDUFV1 CALM3 CHD4 GANAB PPP2R1A HNRNPA1 SART1 SF3B2 URM1 PARK7 FAU CCT7 ERP29 COX6B1 PPP1CA MCM7 NONO CYC1 SOD1 TATDN2 PPM1G COX4I1 SNRPA PSMD8 TRIM28 EIF3C VDAC2 DDX49 HDAC1 ANP32B HNRNPAB RPS12 PSMB4 PDAP1 RAN DDOST LSM7 UQCRH SMARCD2 COPE UBE2L3 AURKB SNRPD2 ANAPC5 UBE2I PCMT1 KHDRBS1 EIF3G GNAS HADHA COPS6 HNRNPUL1 SF3A2 NCL DEK RALY COX6A1 SNRPB SDHA TUFM DAZAP2 CTBP1 SET RPLP2 PTBP1 RAD23A GNB2 YBX1 PSMB1 EEF1D FUS EIF3M RPL18 PSMB7 EIF4B RPS24 HDGF XRCC6 ILF3 SNRNP200 MTDH EEF2 RPS6 UBA2 COX7C MRPL9 TARDBP PSMC1 NPM1 RPL36AL NACA KXD1 POLE3 CANX PUF60 HSP90AB1 RSL1D1 EIF4A1 PABPC1 SUMO3 HSPD1 up
## GNF2_PCNA 0.0028818 0.012315 0.7246420 3.178123 0 65 MCM2 MCM5 HMGB2 FEN1 ESPL1 DNAJC9 SLBP PRC1 MCM7 RAD54L MCM3 MCM6 SHCBP1 MCM4 RACGAP1 CDC20 RRM1 HNRNPAB FOXM1 CCNA2 KIF18B MKI67 TPX2 PA2G4 BIRC5 CDCA8 RFC4 KIF11 GINS2 MYBL2 ZWINT FANCI PRIM1 TYMS CCNB2 KIF15 GMNN SMC4 RAD51AP1 RRM2 DTL BUB1B PLK4 ASPM GINS1 HMMR TOP2A PAXIP1 CENPE NUSAP1 DLGAP5 SMC2 AURKA MELK TTK TMPO CENPF CKS2 up
## GNF2_CCNA2 0.0028818 0.012315 0.7215419 3.164526 0 65 MCM2 HMGB2 FEN1 ESPL1 PLK1 PRC1 NCAPD2 MCM7 MCM3 MCM6 SHCBP1 KIF4A ASF1B MCM4 RACGAP1 CDC20 KIF20A RRM1 FOXM1 CCNA2 AURKB KIF18B MKI67 TPX2 BIRC5 CDCA8 RFC4 KIF11 GINS2 ZWINT FANCI PRIM1 TYMS CCNB2 EZH2 GMNN SMC4 RAD51AP1 RRM2 UBE2C CENPA NCAPG BUB1B ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 HJURP SMC2 AURKA MELK TTK TMPO CENPF CKS2 KIF14 up
## GNF2_CCNB2 0.0027027 0.012315 0.7319489 3.111676 0 54 MCM2 HMGB2 FEN1 ESPL1 PRC1 KIF2C PTTG1 SHCBP1 UBE2S KIF4A MCM4 RACGAP1 CDC20 KIF20A RRM1 FOXM1 CCNA2 KIF18B TPX2 OIP5 NCAPH BIRC5 CDCA8 BUB1 RFC4 KIF11 SPAG5 ZWINT TYMS CCNB2 PBK GMNN SMC4 RRM2 UBE2C BUB1B PLK4 ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 SMC2 AURKA MELK TTK CENPF CKS2 up
## MORF_FBL 0.0036496 0.012315 0.6182818 3.084562 0 129 GPI SRSF9 FBL MCM2 EIF3K NUDT1 BANF1 NDUFS3 NDUFV1 PPP2R1A HNRNPA1 PRMT1 RUVBL2 TBL3 PARK7 FAU CCT7 IDH3B MCM7 NONO CYC1 SOD1 PPM1G POLR2I FIBP SNRPA LSM4 PSMD8 TRIM28 EIF3C VDAC2 DDX49 ANP32B NME1 HNRNPAB PDAP1 RAN DDOST LSM7 UQCRH EIF3I UBE2L3 AURKB SNRPD2 ANAPC5 UBE2I KHDRBS1 EIF3G CS HNRNPUL1 SF3A2 NCL DEK RALY SNRPB TUFM SET RAD23A YBX1 PSMB1 FUS TMEM147 PSMB7 AHCY EIF4B HDGF XRCC6 ILF3 UBA2 MRPL9 TARDBP ILF2 KXD1 POLE3 PUF60 HSP90AB1 C1QBP RSL1D1 EIF4A1 SUMO3 HSPD1 up
## GCM_CSNK2B 0.0031056 0.012315 0.6533484 3.080233 0 87 SRSF9 HNRNPM PSMC3 TBCB CFL1 PSME1 GPS2 PCBP1 DHPS HNRNPA1 PRMT1 SF3B2 PFN1 PTMA LMNB2 NONO POLR2G APEX1 POLG SNRPA PSMD8 TRIM28 SNRPD3 EIF3C UBB ANP32B NASP PSMB4 SNRPD2 KHDRBS1 RPL19 RPSA NCL RPS16 IK HNRNPL SET EIF3F YBX1 RPL3 FUS RPL18 EIF4B EEF2 ILF2 NPM1 RPL11 NACA SRSF4 PPIA HSP90AB1 RPL23 BUD31 RHOA RPL4 PSMB2 PWP1 NDUFA12 up
## MORF_PHB 0.0032787 0.012315 0.6244502 3.064670 0 113 RBBP8 MRPL28 HMG20B PRKCSH ELK1 EML3 MCRS1 PKMYT1 SCARB1 FANCG NUP62 PSMD2 SDR39U1 MEA1 GRK6 NELFB PLIN3 MFN2 WDR62 DDB1 POLR2A MGAT1 SH2B1 ESYT1 TUBGCP2 CAD XPO6 PCGF2 NAP1L4 OTUB1 FDXR CHD3 RABGGTA PSMD3 WDR18 TCOF1 PSMB6 PCGF1 ILVBL SRRT ALDH4A1 PHB ERAL1 TERF2IP CS CNPPD1 CDC25C COPS6 AATF TFAP4 AFG3L2 RTCB HNRNPL SFSWAP BAHD1 EIF6 DDX11 TOMM34 PABPN1 CPSF4 MTX1 BRD3 RPA2 CIB1 NFYB CSNK1D ILF2 SLC12A4 up
## GNF2_CDC20 0.0026667 0.012315 0.7226913 3.054815 0 53 MCM2 ESPL1 PLK1 PRC1 KIF2C PTTG1 SHCBP1 UBE2S KIF4A MCM4 RACGAP1 CDC20 KIF20A RRM1 FOXM1 CCNA2 RAN AURKB KIF18B MKI67 TPX2 NCAPH BIRC5 CDCA8 BUB1 KIF11 SPAG5 ZWINT TYMS CCNB2 GMNN SMC4 RRM2 UBE2C BUB1B PLK4 ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 SMC2 AURKA MELK TTK CENPF CKS2 up
## GNF2_MCM4 0.0027778 0.012315 0.7329234 3.051374 0 52 MCM2 MCM5 FEN1 CENPM POLD1 ESPL1 MCM7 LMNB1 MCM3 MCM6 ASF1B MCM4 RACGAP1 CDC20 NASP RRM1 FOXM1 CCNA2 AURKB KIF18B PA2G4 CDCA8 BUB1 RFC4 KIF11 GINS2 ZWINT FANCI TYMS CCNB2 GMNN SMC4 RAD51AP1 RRM2 UBE2C BUB1B ASPM GINS1 HMMR TOP2A AURKA MELK TTK CKS2 KIF14 PCNA MAD2L1 NDC80 up
## GNF2_CENPF 0.0028011 0.012315 0.7036046 3.045105 0 58 MCM2 HMGB2 FEN1 DNAJC9 PRC1 MCM7 MCM3 PTTG1 SHCBP1 UBE2S KIF4A CDC20 RRM1 CCNF FOXM1 DTYMK CCNA2 KIF18B MKI67 TPX2 BIRC5 CDCA8 MCM10 RFC4 KIF11 GINS2 MYBL2 ZWINT FANCI PRIM1 TYMS CCNB2 KIF15 SMC4 RRM2 UBE2C PLK4 ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 HJURP SMC2 AURKA TTK TMPO CENPF CKS2 up
## MORF_AATF 0.0036630 0.012315 0.5801246 3.035890 0 191 MCM2 MCM5 PIN1 RPN1 SART3 EIF3K PRKCSH CLSTN1 PKMYT1 SSRP1 SCARB1 THOP1 NUP62 PSMD2 SGTA EIF2B5 CSK SDR39U1 NELFB RUVBL2 MFN2 RUVBL1 SMARCC2 DDB1 POLR2A ARFGAP2 IDH3B NONO CYC1 POLR2I FIBP ESYT1 TXLNA CAD XPO6 SNRPA NAP1L4 CTDNEP1 VDAC2 DDX49 PSMD3 HUWE1 WDR18 POP5 SAFB NUDC TCOF1 HNRNPAB PSMB6 PSMB3 DDX39A LSM7 EIF3I DHX38 UBE2L3 SRRT ALDH4A1 ANAPC5 PHB UBE2I KHDRBS1 ALG3 TERF2IP CS CNPPD1 COPS6 AATF TFAP4 TRAPPC3 NCL IMMT AFG3L2 DEK RALY ACLY IK SDHA TUFM RTCB SET SFSWAP RAD23A EIF6 FUS EIF3M PABPN1 BRD8 MTX1 PSMB7 RPA2 PTDSS1 KDM3B SNRNP200 CDK2 MTOR OXA1L MRPL9 MDH1 ILF2 DNAJC11 PDE6D HSPA8 KXD1 POLE3 CANX PUF60 up
## MORF_DAP3 0.0035461 0.012315 0.5798139 3.032708 0 179 SRSF9 AP2M1 PIN1 EIF3K TBCB COX5B MRPL23 BANF1 NDUFS3 CNBP NDUFV1 GANAB PSMD2 EIF2B5 SDR39U1 PPP2R1A POLR2H NELFB RUVBL2 TBL3 PARK7 CCT7 COX6B1 SMARCC2 DDB1 AHCYL1 ARFGAP2 IDH3B NONO CYC1 POLR2I FIBP COX4I1 SNRPA NAP1L4 COX8A CAPZB PSMD8 CTDNEP1 VDAC2 DDX49 STOML2 HUWE1 POP5 DGUOK HNRNPAB PSMB4 PDAP1 PSMB6 PSMB3 RAN DNPEP DDOST UQCRH EIF3I UBE2L3 ANAPC5 UBE2I KHDRBS1 ALG3 CS NCBP2 COPS6 HNRNPUL1 AATF IMPDH1 HAX1 TRAPPC3 NCL AFG3L2 DEK RALY ACLY COX6A1 IK SNRPB SDHA TUFM RTCB CTBP1 SET VGLL4 EIF6 PSMB1 NIPSNAP1 UBA1 RHEB EIF3M TMEM147 BRD8 PSMB7 BRD3 SNRNP200 ATP6V1F COX7C DDT OXA1L MRPL9 MDH1 up
## GNF2_CDC2 0.0028329 0.012315 0.6985399 3.021587 0 59 MCM2 HMGB2 FEN1 DNAJC9 PRC1 PTTG1 SHCBP1 UBE2S KIF4A CDC20 KIF20A RRM1 CCNF FOXM1 CCNA2 KIF18B MKI67 TPX2 BIRC5 CDCA8 RFC4 KIF11 GINS2 MYBL2 ZWINT FANCI PRIM1 TYMS CCNB2 EZH2 KIF15 SMC4 RRM2 UBE2C NCAPG PLK4 ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 HJURP SMC2 AURKA MELK TTK TMPO CENPF CKS2 up
## GNF2_RRM1 0.0031949 0.012315 0.6463726 3.015169 0 86 MCM2 MCM5 HMGB2 FEN1 SSRP1 CENPM SLBP PRC1 MCM7 MCM3 MCM6 PCCB SHCBP1 MCM4 CHCHD3 RACGAP1 CDC20 NASP RRM1 HNRNPAB FOXM1 DTYMK CCNA2 RAN SNRPD1 AURKB KIF18B MKI67 PA2G4 BIRC5 CDCA8 NUP37 RFC4 KIF11 GINS2 ZWINT FANCI PRIM1 TYMS CCNB2 GMNN SMC4 RAD51AP1 RRM2 UBE2C DTL BUB1B PLK4 ASPM GINS1 HMMR TOP2A CENPE NUSAP1 DLGAP5 SMC2 AURKA MELK TTK TMPO CENPF CKS2 KIF14 PCNA SNRPG NDC80 up
## GNF2_HMMR 0.0026882 0.012315 0.7343434 3.000832 0 46 MCM2 FEN1 ESPL1 PLK1 PRC1 SHCBP1 MCM4 CDC20 KIF20A RRM1 FOXM1 CCNA2 AURKB KIF18B MKI67 BIRC5 CDCA8 BUB1 KIF11 GINS2 ZWINT TYMS CCNB2 GMNN SMC4 RRM2 UBE2C BUB1B PLK4 ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 SMC2 AURKA MELK TTK CENPF CKS2 PCNA NDC80 up
## GNF2_CKS2 0.0027100 0.012315 0.7233010 2.981978 0 48 MCM2 HMGB2 FEN1 SLBP PRC1 PTTG1 SHCBP1 MCM4 RACGAP1 CDC20 KIF20A RRM1 HNRNPAB FOXM1 CCNA2 SNRPD1 BIRC5 RFC4 GINS2 ZWINT FANCI TYMS CCNB2 GMNN SMC4 DTL PLK4 ASPM GINS1 HMMR TOP2A CENPE NUSAP1 DLGAP5 SMC2 TTK CENPF CKS2 PCNA NDC80 up
## MORF_PPP1CA 0.0036496 0.012315 0.5843863 2.971235 0 153 SRSF9 BLOC1S1 AP2S1 AP2M1 PSMC3 MBD4 EIF3K NDUFA1 COX5B VCP CLTA BANF1 NDUFS3 ARF5 CNBP NDUFV1 GANAB PPP2R1A PRMT1 SF3B2 URM1 C9orf16 PARK7 CCT7 ERP29 COX6B1 PPP1CA UTP18 CDIPT NONO CYC1 ARHGDIA POLR2G SOD1 PPM1G POLR2I FIBP AP1B1 COX4I1 ENSA ARPC1B PSMD8 TRIM28 EIF3C DDX49 STOML2 HDAC1 ANP32B PSMD9 HNRNPAB PSMB4 PDAP1 RAN DNPEP SMARCD2 COPE SNRPD2 COX5A KHDRBS1 DCTN2 HNRNPUL1 RALY RAD23B COX6A1 TUFM CTBP1 SET PSMB1 UBA1 ARF3 NDUFA2 EEF1D TMEM147 COX6C HDGF PSMD7 MTDH HARS2 MRPL9 MDH1 TECR PSMC1 COIL RPL36AL POLE3 CANX PUF60 SUMO3 HSPD1 BUD31 PSMB2 RER1 up
## GNF2_RFC4 0.0027933 0.012315 0.6883067 2.959938 0 57 MCM2 RANBP1 TIMELESS FEN1 SSRP1 RFC5 SLBP LIG1 NCAPD2 MCM7 RAD54L SUPT16H MCM3 MCM6 MCM4 RRM1 KNTC1 FOXM1 CCNA2 RAN SNRPD1 BIRC5 MCM10 RFC4 KIF11 GINS2 ZWINT FANCI PRIM1 TYMS CCNB2 GMNN SMC4 RAD51AP1 UBE2C PLK4 ASPM GINS1 MSH6 TOP2A SMC2 TTK CENPF CKS2 up
## GNF2_SMC4L1 0.0030769 0.012315 0.6448948 2.950804 0 80 MCM2 MCM5 HMGB2 FEN1 SSRP1 DNAJC9 SLBP PRC1 MCM7 SUPT16H MCM3 PCCB SHCBP1 MCM4 RACGAP1 CDC20 ANP32B NASP RRM1 HNRNPAB FOXM1 DTYMK CCNA2 SNRPD1 KIF18B CDCA8 RFC4 DEK KIF11 GINS2 ZWINT FANCI PRIM1 TYMS CCNB2 GMNN SMC4 RAD51AP1 DUT DTL FBXO5 BUB1B PLK4 ASPM GINS1 HMMR TOP2A NUSAP1 DLGAP5 SMC2 AURKA SRSF1 TTK TMPO CENPF CKS2 PCNA SNRPG NDC80 up
## MORF_CTBP1 0.0036630 0.012315 0.5747390 2.944610 0 159 SRSF9 AP2M1 PIN1 RPN1 TADA3 MBD4 EIF3K COX5B MRPL23 CLTA NDUFS3 CNBP NDUFV1 CHD4 GANAB CSK PPP2R1A WDR1 SF3B2 PARK7 CCT7 COX6B1 MRPS12 PPP1CA ZNF384 ARFGAP2 IDH3B NONO CYC1 POLR2I AP1B1 COX4I1 CAPZB CTDNEP1 VDAC2 DDX49 AP3D1 HDAC1 ANP32B HNRNPAB RAN DHX38 UBE2L3 ANAPC5 UBE2I PCMT1 KHDRBS1 ACAA1 HADHA SNRNP70 COPS6 HNRNPUL1 IMPDH1 LYPLA2 ARHGAP1 DIAPH1 TRAPPC3 NCL DEK ACLY GNB1 DAZAP2 CTBP1 SET PTBP1 RAD23A GNB2 MAEA PSMB1 UBA1 RHEB NDUFA2 GAK PSMB7 HDGF XRCC6 SNRNP200 MTDH UBA2 COX7C MRPL9 MDH1 TARDBP NACA FBXO9 ADD1 KXD1 MGRN1 CANX PUF60 up
## MORF_ESPL1 0.0027027 0.012315 0.6874803 2.922630 0 54 MCM2 NUDT1 FEN1 SSRP1 POLA2 ESPL1 DNMT1 DNAJC9 PLK1 KHSRP LMNB2 MCM3 MCM6 PPM1G SNRPA TRIM28 CLPP NUDC RRM1 HNRNPAB FOXM1 MFAP1 AURKB CS BUB1 RFC4 AFG3L2 KIF11 GNB1 CCT5 ZWINT RAD23A TYMS FUS up
## GNF2_BUB1B 0.0026596 0.012315 0.7035208 2.915359 0 49 MCM2 CENPM POLD1 ESPL1 PLK1 NCAPD2 LMNB1 MCM3 ASF1B MCM4 RACGAP1 CDC20 NASP KIF20A RRM1 CCNA2 AURKB PA2G4 CDCA8 BUB1 KIF11 SPAG5 ZWINT FANCI TYMS CCNB2 CEP55 GMNN SMC4 RRM2 UBE2C BUB1B ASPM GINS1 HMMR TOP2A HJURP AURKA MELK TTK NUP205 KIF14 PCNA NDC80 up
## GNF2_RRM2 0.0025575 0.012315 0.7377554 2.911497 0 39 MCM2 CENPM ESPL1 PLK1 LMNB1 MCM3 MCM6 MCM4 CDC20 RRM1 FOXM1 CCNA2 AURKB KIF18B MKI67 BIRC5 CDCA8 BUB1 KIF11 ZWINT TYMS CCNB2 GMNN RRM2 UBE2C BUB1B ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 AURKA MELK CENPF PCNA NDC80 up
## MORF_G22P1 0.0035842 0.012315 0.5642926 2.902605 0 158 SRSF9 HNRNPM FBL MYL6B COMMD4 AP2M1 EIF3K NUDT1 COX5B MRPL23 NDUFS3 NDUFV1 CHD4 GANAB HNRNPA1 WDR1 PRMT1 PARK7 FAU CCT7 COX6B1 IDH3B MCM7 NONO PPM1G POLR2I AP1B1 COX4I1 CDC37 SNRPA PSMD8 TRIM28 EIF3C CTDNEP1 VDAC2 DDX49 AP3D1 HDAC1 ANP32B PSMB3 RAN LSM7 UQCRH EIF3I UBE2L3 SNRPD2 TTC1 ANAPC5 UBE2I PCMT1 KHDRBS1 EIF3G NDUFS5 HADHA EIF3D HNRNPUL1 IMPDH1 NCL DEK ACLY SNRPB TUFM CTBP1 SET PTBP1 RAD23A NDUFAB1 MAEA YBX1 PSMB1 FUS EIF3M PSMB7 PDIA6 HDGF XRCC6 TXNL4A SNRNP200 CDV3 UBA2 COX7C MDH1 TARDBP ILF2 NPM1 SDHB NACA KXD1 PUF60 HSP90AB1 EIF4A1 SUMO3 HSPD1 up
## GNF2_FEN1 0.0027027 0.012315 0.6803102 2.892148 0 54 MCM2 MCM5 HMGB2 FEN1 RFC5 DNAJC9 PRC1 MCM7 MCM3 PCCB SHCBP1 MCM4 RACGAP1 NASP RRM1 HNRNPAB FOXM1 DTYMK CCNA2 SNRPD1 KIF18B RFC4 KIF11 GINS2 ZWINT FANCI TYMS CCNB2 GMNN SMC4 RAD51AP1 DUT DTL PLK4 GINS1 HMMR TOP2A NUSAP1 DLGAP5 TTK CENPF CKS2 up
## MORF_NPM1 0.0036232 0.012315 0.5665159 2.869369 0 149 UBC RPLP1 OAZ1 CFL1 MRPL23 HNRNPA1 HMGN2 PARK7 TUBA1B FAU CCT7 PFN1 RPLP0 PTMA NONO ACTB COX4I1 DDX49 MAZ UBB ENO1 ANP32B RPS12 RAN UQCRH RPL13 UBE2L3 UBE2I GNAS EIF3D RPL19 COPS6 RPL38 LDHA NCL RPS16 RPL27A COX6A1 RPL35 SNRPB RPS28 RPLP2 EIF3F YBX1 RPL3 PSMB1 EEF1D RPL12 RPS2 RPL22 EIF3M RPL18 RPS24 HDGF XRCC6 RPS3 EEF2 RPS6 UBA2 COX7C RPL13A NPM1 RPL18A RPS14 RPL11 NACA PPIA HSP90AB1 EIF4A1 PABPC1 RPL23A RPL23 RPS20 SUMO3 HSPD1 RPL8 RHOA RPL4 SRP14 RPS27A STRAP RPL30 up
## GNF2_TTK 0.0025253 0.012315 0.7334487 2.864291 0 38 MCM2 FEN1 PRC1 KIF2C MCM4 RACGAP1 CDC20 RRM1 FOXM1 CCNA2 KIF18B TPX2 RFC4 KIF11 GINS2 ZWINT FANCI TYMS CCNB2 GMNN SMC4 BUB1B PLK4 ASPM HMMR TOP2A NUSAP1 HJURP SMC2 MELK TTK CENPF CKS2 PCNA NDC80 up
## MORF_ACTG1 0.0035971 0.012315 0.5741053 2.855880 0 127 UBC MYL6 RPLP1 OAZ1 COX5B CFL1 BTBD2 HNRNPA1 HMGN2 TUBA1B FAU PFN1 RPLP0 PTMA ZFPL1 ACTB COX4I1 COX8A MAZ UBB ENO1 RPS12 RAN RPL13 UBE2I GNAS RPL19 LYPLA2 RPL38 LDHA NCL RPS16 RPL27A COX6A1 SNRPB DAZAP2 RPS28 RPLP2 YBX1 RPL3 PSMB1 RPL12 RPL22 RPL18 RPS24 HDGF RPS3 EEF2 RPS6 COX7C RPL13A NPM1 RPL18A RPS14 RPL11 NACA PPIA JUND HSP90AB1 EIF4A1 PABPC1 RPL23A RPL23 RPS20 SUMO3 RPL8 RHOA RPL4 SRP14 RPS27A RPL30 RPL28 ARPC2 JTB up
fgsea_plot(fgsea_res$res_c5, pathways_title='C5 GO genes', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ------------------------------------------------------------ ---------- ---------- ---------- --------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------
## GO_FICOLIN_1_RICH_GRANULE 0.0030581 0.0417418 0.5496555 2.710793 0 123 GPI PKM PSMC3 HK3 ALDOA VCP GSDMD CAPN1 PSMD13 PSMD2 FCN1 PFKL ACTR1B PGAM1 HSPA6 GMFG COTL1 ALDOC FTH1 KPNB1 PLEKHO2 PSMD3 HUWE1 COMMD9 C1orf35 PDAP1 VCL APEH DBNL AMPD3 CDA GSN IMPDH1 ALAD CALML5 CTSZ ACLY PGM1 CTSB PSMB1 CTSD GUSB HBB ATG7 GSTP1 PSMB7 APAF1 XRCC6 PSMD7 MVP EEF2 PSMC2 CST3 CANT1 ILF2 CSTB CAB39 HSPA8 GYG1 PPIA QPCT HSP90AB1 KCMF1 BIN2 SRP14 LRG1 MMP9 PRDX4 PNP up
## GO_CELL_CYCLE_DNA_REPLICATION 0.0026525 0.0417418 0.6258798 2.684111 0 61 MCM2 MCM5 CDC45 POLE4 FEN1 POLA2 DBF4B CDT1 POLD1 RFC5 POLE LIG1 POLD4 MCM7 MCM3 MCM6 DONSON RAD51 MCM4 RTEL1 BCL6 RFC4 E2F7 WIZ PRIM1 GMNN RPA2 FBXO5 GINS1 POLD2 RPA1 ZNF830 POLE3 up
## GO_NUCLEOSOME_BINDING 0.0025907 0.0417418 0.6171427 2.581652 0 54 RNF168 MTA2 MBD3 SSRP1 CHD4 PHF19 HMGN2 UHRF1 SMARCC2 SMARCB1 ACTB SUPT16H MLLT6 HMGN5 NAP1L4 SPHK2 CABIN1 HDAC1 NOC2L ARID1A GATAD2B GLYR1 SMARCD2 SUPT6H ZNHIT1 HMGN4 RCC1 up
## GO_DNA_DEPENDENT_DNA_REPLICATION 0.0031949 0.0417418 0.5128728 2.566426 0 138 MCM2 MCM5 CDC45 TIMELESS CDK2AP1 POLE4 FEN1 GINS3 WRNIP1 POLA2 DBF4B CDT1 POLD1 RFC5 CHTF18 POLE ORC1 LIG1 POLD4 EME2 HMGA1 POLQ MCM7 PNKP ALYREF MCM3 MCM6 TICRR GINS4 TONSL POLG DONSON RAD51 CDC34 CDK9 MCM4 STOML2 DSCC1 WDR18 RECQL4 RTEL1 CDC6 RECQL5 EME1 BCL6 MCM10 RFC4 E2F7 WIZ GINS2 DNAJA3 PRIM1 BLM CCNE1 DDX11 ATG7 GMNN RPA2 FBXO5 LRWD1 POLN GINS1 CDK2 POLD2 RPA1 up
## GO_GLYCOLYTIC_PROCESS_THROUGH_FRUCTOSE_6_PHOSPHATE 0.0024213 0.0417418 0.7609477 2.566219 0 23 GPI PFKM PKM HK3 HK1 ALDOA GAPDH GALK1 PFKP PFKL PGAM1 ALDOC ENO1 HK2 GAPDHS up
## GO_DNA_REPLICATION 0.0039216 0.0417418 0.4663408 2.556357 0 250 RBBP8 HRAS MCM2 MCM5 CDC45 TIMELESS RAD9A CDK2AP1 POLE4 RAD9B FEN1 GINS3 WRNIP1 SSRP1 POLA2 TREX1 DBF4B CDT1 PTMS POLD1 RFC5 CHTF18 POLE PPP2R1A ORC1 CHAF1A LIG1 POLD4 EME2 HMGA1 KAT5 RMI2 POLQ CHEK1 MCM7 PNKP ALYREF SUPT16H MCM3 MCM6 TICRR GINS4 TONSL POLG DONSON RAD51 E4F1 ING4 CHAF1B CDC34 CDK9 PIF1 MCM4 STOML2 NFIC DSCC1 WDR18 NASP RNASEH2A RRM1 RECQL4 JUN CCNA2 RTEL1 GRWD1 CDC6 KCTD13 REPIN1 CLSPN RECQL5 EME1 BCL6 TOPBP1 DTD1 UCN MCM10 RFC4 E2F7 WIZ GINS2 DNAJA3 SIN3A SLX4 SET PRIM1 IGHMBP2 BLM CCNE1 DDX11 POLL ATG7 ESCO2 ATF1 BRCA1 TOP1MT GMNN RRM2 DUT RPA2 DTL FBXO5 LRWD1 POLN GINS1 up
## GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY 0.0032154 0.0417418 0.4959577 2.550787 0 156 PSMC3 PSMC5 PSME2 CLIP3 PSME1 GPS2 PSMD13 ACTN4 PSMD2 PTK2B PSMC4 PYCARD TNFSF9 COMMD7 RNF31 PSMA7 TNFRSF1B ADAM17 PIAS4 PSMB10 TNFRSF1A PSMD8 PELI3 PSMD3 RFFL TNFRSF25 PSMD9 PSMB5 SHARPIN PSMB4 LTBR MADD PSMB6 CD40 PSMD4 PSMB3 TRAIP MIR152 TNFRSF18 TNFRSF14 CARD14 TNFSF12 RELA KRT18 SYK TRAF1 SPPL2B TNFSF13 TNFRSF8 MAP3K14 RBCK1 PSMB1 TNFRSF4 GSTP1 TNFRSF12A CDIP1 PSMB7 PYDC2 FOXO3 CD27 TMSB4X TNFRSF9 TRADD PSMD7 KRT8 STAT1 PYDC1 PSMC2 SPHK1 TRAF2 PSMC1 TRAF3 up
## GO_HISTONE_BINDING 0.0034602 0.0417418 0.4857602 2.540432 0 182 CTCFL MCM2 RNF168 SART3 ANP32A PIH1D1 KDM8 NPM3 SSRP1 FAM156A PKN1 SPIN2B PHF19 KAT5 UHRF1 NCAPD2 SMARCC2 ZMYND8 PTMA APBB1 BAZ2A CXXC1 SUPT16H ING2 COPRS MLLT6 TONSL SPHK2 NCAPG2 ING4 PARP9 ASF1B PHF13 CHAF1B CHD8 BCAS3 SBNO2 DPF2 CBX4 YEATS2 ANP32B NASP NOC2L NCAPD3 PRMT6 SRCAP HINFP GLYR1 SMARCA2 KAT8 GRWD1 ATAD2 SUPT6H CD1D KMT2D DPF1 CDYL SFMBT2 CTSL DEK RCC1 CBX8 ING1 SNCA SET RAG1 CARM1 WRAP53 L3MBTL2 BRD3 DPF3 KDM4A MCM3AP LRWD1 ANP32C USP51 KAT6B PWWP2A CHD5 STAT1 BRD4 SAP30L MSH6 BRD1 NPM1 PRMT7 L3MBTL1 DTX3L HJURP WDTC1 up
## GO_MONOSACCHARIDE_CATABOLIC_PROCESS 0.0026316 0.0417418 0.6001628 2.519408 0 57 GPI PFKM ALDH1A1 PKM HK3 HK1 ALDOA GAPDH GALK1 PFKP BAD PFKL PGAM1 AKR1A1 ALDOC MIR210 GLYCTK ENO1 HK2 GALM GAPDHS KHK PGM1 FUT7 GALE GALT ACTN3 GCK DCXR up
## GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY 0.0034130 0.0417418 0.4853867 2.499382 0 163 S100A8 PPIF FAM162A NUPR1 TPD52L1 RAD9A S100A9 PRR7 SLC9A3R1 FADD DEDD2 G0S2 HTRA2 PPP2R1A DAPK3 BAD CHCHD10 BID PYCARD PARK7 TRAF7 DDIT3 PPP1CA NFATC4 ZNF205 SOD1 PML LGALS9 FIS1 PIAS4 BBC3 BAX MIR210 CTSC UBB PINK1 PDCD5 ADORA2A NKX3-1 LTBR BNIP3 BAK1 BECN1 TNFSF12 MLLT11 YWHAH YWHAG GSN GZMB TFAP4 HIP1R E2F1 RIPK3 DAB2IP LCK PLEKHF1 PLA2G6 RBCK1 CASP2 TP63 TNFRSF12A FBXW7 TNFSF10 APAF1 RNF183 CRADD SMAD3 up
## GO_TYPE_I_INTERFERON_PRODUCTION 0.0030769 0.0417418 0.5081102 2.484843 0 120 IL10 HMGB2 PIN1 TRIM21 UBE2L6 IRF3 TREX1 RNF26 POLR3A CD14 POLR2H DDX41 PYCARD PTPRS POLR2E POLR2F GPATCH3 CACTIN NLRX1 RIPK2 IRF5 POLR3K STAT6 ZCCHC3 TICAM1 TRAIP POLR2L PQBP1 TRIM56 RNF135 RELA CREBBP NLRC5 SYK NFKB2 POLR3GL UBA7 RELB IRF7 IKBKE SIRPA RIOK3 IRF1 HAVCR2 XRCC6 POLR3D NLRC3 STAT1 MIR26B POLR3E MYD88 TRAF3 HERC5 PTPN11 NPLOC4 TRIM25 PRKDC HSPD1 up
## GO_LARGE_RIBOSOMAL_SUBUNIT 0.0029240 0.0417418 0.5126237 2.478811 0 108 MRPL28 MRPL21 MRPL11 RPLP1 MRPL23 C12orf65 MRPL27 MRPL12 MRPL52 MRPL40 MRPL41 MRPL54 RPLP0 MRPL17 MRPL51 MRPL37 MRPL20 RPL13 MRPL10 RPL39L MPV17L2 RPL19 MRPL16 RPLP0P6 RPL38 MRPL4 RPL41 RPL27A RPL35 MRPL49 RPLP2 MRPL34 MRPL55 MRPL38 NDUFAB1 RPL3 RPL12 RPL22 RPL36 RPL18 MRPL3 MRPL24 RPL26L1 MRPL18 MRPL9 RPL13A NPM1 RPL18A RPL11 RPL36AL MRPL43 RPL23A RPL23 RPL8 RPL4 RPL30 UBA52 MRPL44 RPL28 RPL37A MRPL33 FXR2 MRPL15 RPL14 MRPL2 RPL35A MRPL46 RPL10A up
## GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME 0.0032680 0.0417418 0.4831787 2.460569 0 152 MRPL28 MRPL21 MRPL11 MRPS11 RPLP1 MRPL23 MRPS34 MRPL27 MRPL12 MRPL52 MRPL41 MRPL54 MRPS7 RPLP0 MRPS12 MRPL17 MRPS16 MRPL51 MRPL37 MRPL20 RPS12 RPL13 MRPL10 RPL39L RPL19 RPSA MRPL16 RPLP0P6 RPL38 MRPL4 RPS15 RPS16 RPL41 RPL27A RPL35 MRPS22 RPS28 MRPL49 RPLP2 MRPL34 MRPS5 MRPL55 RPL3 RPL12 RPS2 RPL22 RPL36 RPL18 RPS21 MRPL3 RPS24 MRPL24 RPL26L1 NDUFA7 RPS3 RPS6 MRPL18 MRPL9 RPL13A RPL18A RPS14 RPL11 RPL36AL MRPL43 MRPS2 RPL23A RPL23 RPS20 RPL8 RPL4 RPS27A RPL30 UBA52 RPL28 RPL37A MRPL33 MRPL15 MRPS23 RPL14 MRPL2 RPL35A MRPL46 RPL10A RPS11 RPS26 RPL37 MRPS15 up
## GO_MITOCHONDRIAL_PROTEIN_COMPLEX 0.0036900 0.0417418 0.4561962 2.459778 0 217 MRPL28 MRPL21 PPIF TIMM10 CHCHD6 NDUFS7 NDUFA4L2 MRPL11 MRPS11 NDUFB7 TIMM8B NDUFA1 MRPL23 C12orf65 NDUFA11 TOMM40 MRPS34 NDUFS3 MRPL27 ROMO1 NDUFV1 MRPL12 TIMM50 MRPL52 MRPL40 MRPL41 UQCRC1 CHCHD10 BCKDK NDUFS8 MRPL54 TIMM13 MRPS7 MRPS12 POLRMT CYC1 NDUFB10 COX4I1 POLG NDUFC1 MRPL17 BAX MRPS16 CHCHD3 MRPL51 MRPL37 MRPL20 FOXRED1 NDUFB6 UQCRH MRPL10 COX5A NDUFS5 HADHA PDK2 MPV17L2 TOMM40L NDUFB2 MRPL16 NDUFB9 MRPL4 IMMT C15orf48 AFG3L2 TOMM22 COX6A1 NDUFS6 SDHA MRPS22 MRPL49 MRPL34 MRPS5 MRPL55 MRPL38 NDUFAB1 PMPCA UQCRFS1P1 NDUFS2 NDUFA2 MRPS26 MICU1 TOMM7 NDUFA13 MTX1 MRPL3 up
## GO_DOUBLE_STRAND_BREAK_REPAIR 0.0036496 0.0417418 0.4572893 2.452005 0 207 XRCC4 RBBP8 MCM2 RNF168 MCM5 CDC45 TIMELESS SIRT6 FEN1 VCP MUS81 REC8 MAGEF1 XRCC1 GGN TNKS1BP1 EME2 KAT5 PRPF19 RMI2 POLQ CHEK1 NABP2 CDCA5 NSMCE1 MCM7 AUNIP APBB1 ZBTB7A PPP4C PARP1 RAD54L SWI5 MCM3 MAD2L2 MCM6 GINS4 PML TONSL PIAS4 RAD51 PARP9 OTUB1 MCM4 BABAM1 NUDT16L1 RECQL4 FOXM1 RTEL1 MGMT KDM2A PRDM9 TERF2IP ERCC1 RECQL5 EME1 ZFYVE26 HUS1B DEK PARP2 GINS2 SLX4 SPIDR BLM DDX11 POLL ESCO2 FUS WRAP53 EYA1 OGG1 BRCA1 TWIST1 RAD51AP1 XRCC2 KDM1A CCDC155 RPA2 TFIP11 XRCC6 AP5S1 RAD51D USP51 POLN AP5Z1 CIB1 ACTR5 SWSAP1 DCLRE1B TRIP13 PARPBP RPA1 PAXIP1 up
## GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION 0.0035842 0.0417418 0.4624703 2.450412 0 195 HAUS5 PSMC3 PSMC5 PSME2 DCTN1 PSME1 DCTN3 DBF4B PSMD13 PSMD2 PPP2R1A SSNA1 ORC1 PLK1 FOXO4 PSMC4 CHEK1 MIIP ATF5 PSMA7 TICRR CEP250 SMARCD3 TAOK2 PSMB10 CEP164 DONSON PRKACA PSMD8 HAUS8 FZR1 SYF2 RCC2 PSMD3 GTSE1 PSMD9 PSMB5 BABAM1 CDK5RAP3 PSMB4 PSMB6 PSMD4 PSMB3 CCNB1 AURKB ZFYVE19 CDC6 TPX2 DCTN2 TUBA4A TUBG1 YWHAG CLSPN CDC25C CDC25A TOPBP1 KCNH5 ODF2 HUS1B NEK2 SIN3A BLM ACTR1A PSMB1 BRCA1 CKAP5 PSMB7 PINX1 TUBB4B SFI1 CEP72 DTL GPR132 MTA3 FBXO5 APP PSMD7 CDK5RAP2 PLK4 NINL CEP152 CDK2 PSMC2 BRD4 HMMR PCNT CSNK1D PAXIP1 PSMC1 NPM1 up
## GO_BASE_EXCISION_REPAIR 0.0025840 0.0417418 0.6210493 2.447703 0 42 UNG MBD4 SIRT6 FEN1 POLD1 POLE XRCC1 LIG1 HMGA1 POLQ NEIL3 APEX1 POLG SMUG1 HUWE1 PRMT6 APEX2 NEIL2 MPG PARP2 MUTYH POLL OGG1 RPA2 FAM168A RPS3 RPA1 up
## GO_DOUBLE_STRAND_BREAK_REPAIR_VIA_BREAK_INDUCED_REPLICATION 0.0023981 0.0417418 0.8829280 2.444418 0 11 MCM2 MCM5 CDC45 MUS81 MCM7 MCM3 MCM6 GINS4 MCM4 GINS2 up
## GO_DNA_CONFORMATION_CHANGE 0.0037736 0.0417418 0.4508849 2.430206 0 221 UBC MCM2 MCM5 PAF1 HMGB2 CDC45 SART3 CDKN2A SIRT6 BANF1 CENPM TREX1 CHD4 RFC5 CHTF18 CHAF1A RUVBL2 HMGA1 CENPN RUVBL1 MIS18A NCAPD2 POLQ DDB1 CDCA5 MCM7 NCAPH2 TOP3B PARP1 RAD54L MCM3 MCM6 GINS4 CHMP1A NAP1L4 NCAPG2 RAD51 ASF1B PHF13 CHAF1B CHD8 PIF1 MCM4 AKAP8L CHD3 UBB CABIN1 ANP32B DSCC1 NASP CENPW CENPP NOC2L NCAPD3 RECQL4 PHF23 CCNB1 RTEL1 UBN1 DDX12P TSPY26P GRWD1 OIP5 PRDM9 NCAPH RECQL5 SOX9 DDB2 CENPO ACIN1 ERCC2 RFC4 DFFB RAD23B GINS2 SET BAHD1 IGHMBP2 BLM CENPH DDX11 TSSK6 HIRA TOP1MT SMC4 CENPA NCAPG XRCC6 IPO4 KAT6B CHD5 GINS1 ERCC3 HHEX AIFM1 RPA1 TOP2A NUSAP1 NPM1 up
## GO_ORGANELLAR_RIBOSOME 0.0027778 0.0417418 0.5266469 2.428374 0 83 MRPL28 MRPL21 MRPL11 MRPS11 MRPL23 C12orf65 MRPS34 MRPL27 MRPL12 MRPL52 MRPL40 MRPL41 MRPL54 MRPS7 MRPS12 MRPL17 MRPS16 MRPL51 MRPL37 MRPL20 CHCHD1 MRPL10 MPV17L2 MRPL16 MRPL4 MRPS22 MRPL49 MRPL34 MRPS5 MRPL55 MRPL38 NDUFAB1 MRPS26 MRPL3 MRPL24 MTG2 NDUFA7 MRPL18 MRPL9 up
## GO_RIBOSOMAL_SUBUNIT 0.0034014 0.0417418 0.4694104 2.426299 0 172 MRPL28 MRPL21 MRPL11 MRPS11 RPLP1 MRPL23 C12orf65 MRPS34 MRPL27 MRPL12 MRPL52 MRPL40 MRPL41 MRPL54 MRPS7 RPLP0 MRPS12 HBA1 MRPL17 MRPS16 MRPL51 MRPL37 MRPL20 RPS12 RPL13 MRPL10 RPL39L MPV17L2 RPL19 RPSA MRPL16 RPLP0P6 RPL38 MRPL4 RPS15 RPS16 RPL41 RPL27A RPL35 MRPS22 RPS28 MRPL49 RPLP2 MRPL34 MRPS5 MRPL55 MRPL38 NDUFAB1 RPL3 RPL12 RPS2 RPL22 MRPS26 RPL36 RPL18 RPS21 MRPL3 RPS24 MRPL24 HBA2 RPL26L1 RPS3 RPS6 MRPL18 MRPL9 RPL13A NPM1 RPL18A RPS14 RPL11 RPL36AL MRPL43 MRPS2 RPL23A RPL23 RPS20 RPL8 LARP4 RPL4 RPS27A RPL30 UBA52 MRPL44 RPL28 RPL37A up
## GO_DNA_PACKAGING 0.0029586 0.0417418 0.4947184 2.419377 0 117 MCM2 PAF1 HMGB2 SART3 CDKN2A SIRT6 BANF1 CENPM CHAF1A HMGA1 CENPN RUVBL1 MIS18A NCAPD2 CDCA5 NCAPH2 CHMP1A NAP1L4 NCAPG2 ASF1B PHF13 CHAF1B AKAP8L CABIN1 ANP32B NASP CENPW CENPP NOC2L NCAPD3 PHF23 CCNB1 UBN1 TSPY26P GRWD1 OIP5 PRDM9 NCAPH SOX9 CENPO ACIN1 DFFB SET BAHD1 CENPH TSSK6 HIRA SMC4 CENPA NCAPG IPO4 KAT6B CHD5 AIFM1 TOP2A NUSAP1 NPM1 HJURP SMC2 CENPT POLE3 up
## GO_DNA_HELICASE_ACTIVITY 0.0026110 0.0417418 0.5415369 2.418954 0 68 MCM2 MCM5 CDC45 CHD4 RFC5 CHTF18 RUVBL2 RUVBL1 POLQ MCM7 MCM3 MCM6 GINS4 RAD51 CHD8 PIF1 MCM4 CHD3 DSCC1 RECQL4 RTEL1 DDX12P RECQL5 ERCC2 RFC4 GINS2 IGHMBP2 BLM DDX11 XRCC6 CHD5 GINS1 ERCC3 up
## GO_ATP_METABOLIC_PROCESS 0.0039526 0.0417418 0.4373879 2.408732 0 254 GPI AAAS PFKM PPIF NDUFS7 NUPR1 PKM SIRT6 HK3 NDUFB7 NDUFA1 DDIT4 HK1 COX5B ALDOA VCP GAPDH NDUFA11 NDUFS3 TREX1 NDUFV1 GALK1 NUP62 PFKFB4 PFKP BAD UQCRC1 CHCHD10 PFKL BID SHMT2 PARK7 MYOG UQCR11 NDUFS8 PGAM1 COX6B1 AK5 ZBTB7A PARP1 CYC1 NDUFB10 ALDOC TREM2 TSPO JMJD8 COX4I1 NDUFC1 SPHK2 COX8A TGFB1 MIR210 STOML2 AK4 ENO1 HK2 PINK1 NUP210 NDUFB6 COX7A1 VPS9D1 CCNB1 UQCRH COX5A GAPDHS NDUFS5 NUP93 AMPD3 NDUFB2 FBP1 NUP37 NDUFB9 NUP85 SEC13 LDHA P2RX7 FAM20C COX6A1 NDUFS6 SDHA SNCA PGM1 NDUFAB1 NADK EIF6 NDUFS2 SLC25A23 NDUFA2 ACTN3 PFKFB3 GCK NDUFA13 COX6C GUK1 CTNS TMSB4X APP ISCU NDUFA7 OGDHL COA6 NUP50 COX7C up
## GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN 0.0034483 0.0417418 0.4589851 2.406573 0 183 AP2S1 AP2M1 PSMC3 PSMC5 TAPBPL PSME2 DCTN1 AP2A1 PSME1 CLTA DCTN3 PSMD13 PSMD2 PSMC4 ACTR1B PYCARD KIF22 PSMA7 RAB7A TREM2 AP1B1 LAG3 KIF2C SEC24C NCF4 PSMB10 AZGP1 KIF4A CAPZB PSMD8 KLC2 RACGAP1 PSMD3 PSMD9 PSMB5 CTSF PSMB4 PSMB6 PSMD4 PSMB3 CALR FCGR2B AP2A2 KIF3C DCTN2 AP1S1 NCF2 DYNLL2 CYBA CD74 SEC13 CTSL KIF11 ACTR1A IFI30 DYNC1I1 SLC11A1 PSMB1 CTSD ITGB5 CTSV KIF15 KIF5A KIF23 CD209 PSMB7 FCGRT AP1M1 VAMP8 PSMD7 FCER1G SPTBN2 HLA-G PSMC2 HFE RILP DNM2 PSMC1 CENPE up
## GO_ANTIGEN_PROCESSING_AND_PRESENTATION 0.0038023 0.0417418 0.4470348 2.404584 0 219 AP2S1 AP2M1 PSMC3 PSMC5 TAPBPL PSME2 DCTN1 RAB35 AP2A1 PSME1 CLTA TREX1 DCTN3 PSMD13 PSMD2 PSMC4 ACTR1B PYCARD NOD2 KIF22 PSMA7 RAB7A TREM2 AP1B1 LAG3 KIF2C SEC24C NCF4 PSMB10 AZGP1 KIF4A CAPZB CD68 PSMD8 RAB34 KLC2 RACGAP1 AP3D1 PSMD3 PSMD9 PSMB5 CTSF PSMB4 PSMB6 PSMD4 PSMB3 CALR FCGR2B RAB10 AP2A2 KIF3C DCTN2 AP1S1 NCF2 CD1D DYNLL2 CYBA CD74 SEC13 CTSL KIF11 RELB ACTR1A IFI30 DYNC1I1 CCL19 SLC11A1 PSMB1 CTSD ITGB5 CTSV KIF15 KIF5A KIF23 CD209 PSMB7 FCGRT AP1M1 VAMP8 RAB33A PSMD7 FCER1G SPTBN2 HLA-G PSMC2 HFE RILP DNM2 PSMC1 CENPE up
## GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY 0.0027855 0.0417418 0.4982166 2.403921 0 103 MCM2 MTA2 PAF1 HMGB2 SART3 NFE2 CDKN2A SIRT6 HIRIP3 CENPM CHAF1A HMGA1 CENPN RUVBL1 MIS18A SMARCC2 SMARCB1 SUPT16H MAP1S SMARCD3 NAP1L4 ASF1B CHAF1B CHD3 CABIN1 ANP32B NASP CENPW CENPP NOC2L ARID1A SMARCD2 UBN1 TSPY26P GRWD1 PADI2 OIP5 PRDM9 SOX9 CENPO SET BAHD1 CENPH up
## GO_PROTEASOME_ACCESSORY_COMPLEX 0.0024272 0.0417418 0.7047729 2.400227 0 24 PSMC3 PSMC5 PSME2 PSME1 PSMD13 PSMD2 ADRM1 PSMC4 PSMD8 PSMD3 PSMD9 PSMD4 up
## GO_NADH_METABOLIC_PROCESS 0.0024691 0.0417418 0.6427647 2.399741 0 34 GPI PFKM PKM HK3 HK1 ALDOA VCP GAPDH PFKP PFKL PGAM1 ALDOC MIR210 ENO1 HK2 GAPDHS up
## GO_SINGLE_STRANDED_DNA_HELICASE_ACTIVITY 0.0023364 0.0417418 0.7767128 2.398411 0 16 MCM2 MCM5 RFC5 CHTF18 POLQ MCM7 MCM6 RAD51 PIF1 DSCC1 RFC4 up
fgsea_plot(fgsea_res$res_c6, pathways_title='C6 oncogenic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ----------------------- ---------- ---------- ----------- ---------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## PRC2_EED_UP.V1_DN 0.0036232 0.0097222 0.5649730 2.944788 0 179 RDH5 AMDHD2 TNK2 ABCB9 MCM2 MCM5 CDC45 CHST3 TRMT2A STXBP2 RASSF1 INCENP POLA2 GSDMD DBF4B TACC3 GALK1 POLD1 BTBD2 PTK2B PFKFB4 CLPB ORC1 PLK1 TCIRG1 TBL3 PACS1 BCKDK TNIP1 TUT1 SIPA1 TOP3B SLC35C2 AP1G2 RAD54L FBXO17 ARRB2 TUBGCP2 QTRT1 BBC3 CAD EXOSC2 CORO1A KIF4A ASF1B CHAF1B ZNF446 RANGAP1 SYMPK CA9 TAF1C LIPE GNAI2 RAPGEF1 RECQL4 MAPK7 HIVEP3 NYNRIN PC CDCA8 IDH2 MCOLN1 CLSPN ALG12 ERCC2 MCM10 ODF2 WIZ VAC14 MYBL2 PCDHGA3 NDRG4 PWP2 FASN SP1 SV2A HMOX1 ABCB8 MICAL1 KIF23 FADS2 TRPM4 TNS4 BUB1B INSIG1 CDK18 GLE1 PHKG2 ATP13A2 TSC2 DCLRE1B FOSL2 SLC12A4 PLXNB1 PRMT7 APLP1 VAV2 up
## RB_P107_DN.V1_UP 0.0031447 0.0097222 0.5750516 2.844940 0 128 HMCES TSSC4 SNCG MCM2 BLVRB MCM5 CDC45 FEN1 INCENP POLD1 RFC5 POLE DNAJC9 SLBP ANAPC11 LIG1 HMGN2 NAA40 PRC1 VEGFB NCAPD2 MCM7 PTMA S100A4 MCM6 GINS4 PML SIVA1 BEX2 ETHE1 KIF4A ASF1B CHAF1B HAUS8 GTSE1 RRM1 CCNF COX6B2 RPL39L NCAPH RHEBL1 TUBG1 WDR90 E2F1 TRPV2 FANCA STMN1 LCK PRIM1 CCNE1 CENPH PAQR4 GMNN RRM2 NXT1 RPA2 CD81 up
## CAMP_UP.V1_UP 0.0035842 0.0097222 0.4802662 2.512845 0 181 AAAS HMGB2 RPN1 ZNF385A ALDOA DDX23 SCARB1 NDUFV1 TMED9 DIP2B PYCR2 CHAF1A CCDC124 RHOT2 PIGS PRMT1 URM1 LONP1 KAT5 METTL17 RUVBL1 AHCYL1 GLRX NLRP1 CNDP2 ECSIT TYMP ZNF367 CEP250 HSPBP1 COX8A WDR24 WASH3P BSCL2 RABGGTA SIL1 NME1 MTHFD2 SESN2 SEC61A1 PPP1R15A UPP1 COPE TGFBI CEBPG SMYD5 WBP1 P4HB PA2G4 CS TOMM40L AATF NQO2 CYBA HAX1 CD74 SEC13 CLPTM1 SAT2 EARS2 TMEM8B PRIM1 MT2A RBCK1 ACSL4 MAEA ATF4 NDUFS2 IFITM3 FBXO42 RNF41 LETMD1 PLSCR1 BLCAP NRSN2 CMTR1 IPO4 HSP90B1 HSPA9 OXA1L ILF2 RPL18A FAHD2A NDRG2 MIDN SLC22A17 up
## ATF2_UP.V1_UP 0.0035842 0.0097222 0.4895294 2.509846 0 165 CARD9 GTF3C5 ABCB9 RBP1 PIN1 NFKBIB DGKZ TK1 ZFR2 GINS3 HOXB1 GNA15 TRPM2 POLD1 G0S2 RSPH6A NME3 LIG1 TCIRG1 PTDSS2 PACS1 HSPA6 SAG MAGEC3 LAS1L S100A4 CORO2B STRA6 FAM102A PLCB3 EMILIN2 RAD51 TSC22D4 REEP2 ARHGAP22 LIPE FOXG1 TSPAN32 PTPRT FOXM1 GALNT6 ENDOG C2CD2L STAT5A UPP1 FSD1 ANKRD11 DCAF4 FOXL2 PELP1 CENPO ZNF324B FGR GUCA1A GINS2 BRAP ALX3 CD3D FGFBP1 NRXN2 KRT7 CLDN1 NNAT APAF1 DTL NCAPG PLK4 ATP13A2 TRIM9 IL32 DIP2A GALR2 PLAU MELK PAFAH1B3 HOXD11 SPRR2C COL2A1 CHRNG PITX1 TRIM14 NEFM ALLC HSD3B1 GRAP CD19 RNF43 CD8A KISS1 PAX1 GMPPB PLBD1 PCP4 CCR4 SH3BGR up
## CSR_LATE_UP.V1_UP 0.0033333 0.0097222 0.4811872 2.455854 0 156 PSMC3 MT1G FEN1 GINS3 SLC16A3 GYS1 POLD1 PSMD2 MT1F DRAP1 UHRF1 WSB2 UTP18 KIF22 MT1H LMNB2 PPP5C IMP4 MCM3 ZNF367 UMPS TPM2 POLR3K C19orf48 SHCBP1 CCDC34 CDK5 FARSA MAZ ALKBH7 NUDC MT1L NOC2L FOXM1 PRMT5 DTYMK EIF5A CDC6 PA2G4 TUBA4A NMB BIRC5 KRT18 TUBG1 CDCA8 PREB CLSPN DCTPP1 ST3GAL4 FANCA MYBL2 ZWINT PDCL3 PRIM1 MT2A CCND3 CASP2 EZH2 TOMM34 PBK GMNN RRM2 UBE2C SRM ASB6 FAM83D IGFBP3 GTF3C6 TRIP13 ILF2 DNAJB11 ANLN up
## GCNP_SHH_UP_LATE.V1_DN 0.0034602 0.0097222 0.4744852 2.442680 0 167 ANKRD33B TCEA2 B3GAT3 VSNL1 PEMT ITGA7 NUDT1 DOK1 PPM1M SSBP4 NECAP2 ACTN4 PAK4 CD276 POLD4 PTPN18 PUS1 AGTRAP MIIP SLC2A1 PPFIA4 LSR EPHB6 MED12 AXIN1 PDCD7 RAB34 MAN2B1 FAHD1 ARAF RMDN3 AMOTL2 FOXD3 ATAD3A ZFYVE19 ANXA7 ZNHIT2 DLG4 TBC1D1 BCL2L2 IRF9 EBI3 MLLT1 LYSMD1 GRIN2C S100A13 EIF6 SLC11A1 ART5 EYA1 GP1BA OGG1 IL4R MRPL3 MDFI FCGRT CDCP1 ITGAE GRB7 FRRS1 PTPRJ HTR3A CD52 SLC25A45 ACOT1 ARID3A KLK6 TMEM214 DSCR8 ACVR1 CLCN6 COX6A2 PLD2 NBEAL2 ZDHHC5 NPTN IKBKG PITPNM1 up
## RB_P130_DN.V1_UP 0.0030030 0.0097222 0.5006340 2.423347 0 114 C12orf10 ZNF428 CHCHD6 KAZN FOXI1 MBD3 TK1 GFER ATP2A1 CUEDC2 ORC1 DUSP13 RUVBL2 NSMCE1 KIF22 POLR2I QTRT1 EXOSC2 LSM4 ELOF1 ZBTB17 OXLD1 SDF2L1 RACGAP1 KIF20A GPN3 AURKB ANAPC5 BIRC5 CYBA SNN RASD1 RIPK3 DCTPP1 SNRPB COL11A2 SLC7A9 SEMA5B SEMA6B CCNB2 SLC11A1 CMTM7 SNTA1 EFTUD2 ENKD1 UBE2C FADS2 PF4 RAD51D RABEPK SIM1 SLC43A3 POLD2 TRAF2 AURKA GLIS2 RASA4 STMN3 SGSM3 up
## E2F1_UP.V1_UP 0.0036364 0.0097222 0.4635926 2.406988 0 173 ERMP1 USF2 TK1 GPN2 FEN1 SLC9A3R1 PPM1M FRAT2 POLA2 THOP1 MAP3K11 SLBP CLN6 PACS1 PRC1 CHEK1 DDB1 SLC7A1 KLHL21 LMNB1 PRADC1 PARP1 TPM2 CAD HSPBP1 CHAF1B MCM4 NASP RRM1 UBN1 AURKB GRWD1 RBM15 RND2 NCAPH MPG BUB1 CNIH2 CYBA ERCC2 PIM1 MCM10 MAP3K3 WBP11 USP39 GPR19 DCTPP1 FMNL3 TYMS BOLA3 EIF6 TAF6 SIRPA TINF2 EZH2 ARF3 ACTN3 VEGFA INO80E UBE2T CSTF2 STIL PLK4 EVL CDV3 TOP2A TRAF3 CDR2L DLGAP5 SMC2 USP10 SRSF4 TYRO3 UPK2 NOP56 BCL2 ELAVL1 ADCY6 SHBG DNAJC2 PITPNM1 VPREB3 up
## CYCLIN_D1_UP.V1_UP 0.0036364 0.0097222 0.4611471 2.394291 0 173 CHGA UBXN1 MYL6 NFE2 HK3 NDUFB7 ZYX SUPT5H PTMS CYP2A7 PLOD1 FOXO4 ITGB1BP1 KIF22 PPP5C DRD5 CETP SELPLG MED12 AXIN1 KCNAB2 PCGF2 HRC TGFB1 FDXR GCHFR CA9 WT1-AS LTBR FCGBP STAT5A EIF5A RPS6KA1 RXRA COX17 HNRNPA0 GPT BIN1 MKI67 CENPB PDE1B TRAF1 MSN DVL1 ST3GAL4 NKG7 EMC1 BMP1 ATP4A BLM SLC6A9 MAD1L1 S100B DNASE2 ABCA2 HAGH SPOCK2 HOXC5 PCSK7 RRAS PLK3 MAT1A FGD1 HBA2 RABEPK TSC2 CD52 RASSF7 SCAP SLC12A4 KLK6 BATF DMWD SYN1 GOT1 CXCR3 GALNS TRIM25 GADD45A ANPEP up
## RB_DN.V1_UP 0.0031646 0.0097222 0.4845637 2.372245 0 123 AAAS ARTN TIMELESS PPM1M DNMT1 TPRA1 DNAJC9 SLBP POLD4 CLN6 STUB1 NUMBL TNFSF9 MCM7 UCK1 RAD54L MCM6 COPRS SIVA1 GCLM PDXP BBC3 MAN1B1 NME4 SLC2A9 C20orf27 TNFRSF18 TMEM54 TUBG1 TGM1 CTDSP1 FBP1 VPS16 ST3GAL4 MRPL49 STMN1 PRIM1 PLA2G6 PLXNB2 CCNE1 SLC7A7 MAPK13 RRM2 NXT1 DCXR AHCY UBE2T ARHGEF40 GRB7 THRA MSH6 SLC2A8 RPA1 DSN1 up
## SRC_UP.V1_UP 0.0033445 0.0097222 0.4702658 2.365389 0 148 AAAS SLC35F4 LPO PIN1 SMTNL1 CLIP3 SLC4A9 STAC3 ANGPTL6 MRPS34 ATOX1 GALK1 CHCHD10 FOXO4 YIF1B ABTB1 TMUB1 PRADC1 FES RFXANK TCEAL3 SLC25A22 TONSL TAF3 MORN3 APC2 IGFALS NAALADL1 MED10 SRC COL26A1 PIK3R5 MATK GRWD1 TMEM106C DNAJC22 CALML5 CEACAM19 FBXO44 PDZD7 GINS2 ETV7 BAHD1 MAPK8IP2 RAB3A ACAP1 QPCTL SOCS1 C19orf73 SLC25A23 SMO TFR2 AGPAT3 MIOX KCNH3 ACY3 ASPSCR1 NKX6-3 HPX GPR55 OPRL1 SYN1 TMEM11 BCL2 SLC26A1 RPRM BMF SLC22A6 MTMR9LP up
## SIRNA_EIF4GI_UP 0.0029326 0.0097222 0.5029082 2.324485 0 87 DDX54 EMC9 EIF3K CORO1B PSAP PSME1 FRAT2 MAGEF1 HTRA2 GSS SUN2 ECI1 FBXO46 SAA1 NDUFS8 NCAPD2 NONO PDHA1 ESYT1 LRPAP1 TNNT1 HSPB1 CTSC IGF2R up
## RAPA_EARLY_UP.V1_DN 0.0034602 0.0097222 0.4480269 2.306470 0 167 CDH22 PTGS1 NFE2L1 FOXI1 ESRRA EIF4EBP1 SLC9A3R1 BCAT2 BRMS1 NAGPA DUSP2 PSMD13 CYP2A7 XRCC1 LHB ACTR1B CCDC85B BCKDK STK11 PSMA7 ATG2A CIB2 SELPLG BBC3 KDM4B NUMA1 PLEKHO2 GALR3 CBX4 HAAO PINK1 MINK1 SCO2 TROAP GRN GPT TFAP2A APBA3 RBMS1P1 FLT3LG NCAPH MARK2 IL11RA SF3A2 GFRA2 GRM1 COL9A2 TSPAN4 NHLH1 SOX10 YIPF2 PISD FAM182B SNAPC4 DPH1 MICU1 SNTA1 GBF1 IL12RB1 MYCN KDM4A GLUL IFI27 FAM168A MAP1A IGFBP3 ITPKC TRIM22 GRM2 WDTC1 KRT17 DUSP14 RNF167 TAF4 CRMP1 up
## PDGF_ERK_DN.V1_DN 0.0031949 0.0097222 0.4598781 2.292859 0 141 BNC1 SLC3A2 MBD3 CIC FRAT2 CEBPB FADD SULT1A1 MAFG ERF MFSD5 MOGS NEFH FAM50B SAC3D1 NCAPH2 MGAT1 FAM102A MNT ADM APC2 PHLPP1 PPP6R1 NOP16 CCNF JUN SCO2 HIC2 C2CD2L HINFP TRAIP JUNB DNAJB1 ZNF500 KDM2A MAPK3 KLHL25 RTN2 BRPF1 PPP2R5B ZNF324 MAP3K3 ARF6 FZD2 DHX34 PISD FBXL14 SNAPC4 MYCN TFIP11 SUOX TMEM115 THAP11 ARHGEF16 SMAD7 DIP2A CDR2L CDK2AP2 TBCC DUSP8 TBKBP1 TMEM11 NFKBIA CDKN1B up
## IL15_UP.V1_UP 0.0036630 0.0097222 0.4339968 2.247424 0 174 TPST2 HSD17B14 IL10 CLSTN3 ZBTB48 SHROOM2 DUSP2 TIMM50 APOBR UTP3 FAM215A LYL1 LSP1 CCDC85B PUS1 OSM ZBTB7A ZNF205 IL1A SLC1A5 FAM214B MFSD12 REEP2 HK2 DHRS3 JUNB GPT TET3 LRP8 FLT3LG CDC25A TRMU ZBTB32 MAF RPP25 PTPN7 CALML5 PIM1 IRF2BP1 HOXC8 CNNM4 LIME1 CCNE1 TNFRSF4 SOCS1 C19orf73 DGKG TNFRSF12A CAPN10 VDR TNFRSF9 FOSL1 PRSS2 SPINT1 RGS3 SLC29A2 NOP2 CDH3 ADAM19 APLP1 SLC7A5 CCL4 CENPT PSG4 HRH3 S100A1 SPP1 SNHG17 ZNF276 up
## AKT_UP_MTOR_DN.V1_UP 0.0034247 0.0097222 0.4149566 2.137813 0 166 HMCES S100A8 MPP2 HCK TMEM40 UBE2R2 FKBP8 RASSF1 FBXO6 METRNL GGA1 FBXL15 HCN2 SAA1 CPE ZNF746 ALDOC ING2 CPNE6 RNF19B SAA2 ELL NOL12 HIC2 JUNB TACSTD2 SGPL1 TPRN ST6GALNAC6 HOXB5 SYT8 SNHG11 TOR3A VAT1 MAN2B2 NFKB2 RASAL3 RASD1 MLLT1 ARRDC4 PDZD11 PFDN2 GUSB RNF41 TNFRSF12A MICU1 ABCA7 GAK PLSCR1 CTNS MYCN PSMD7 MVP KCNH3 PTPRJ RUNDC3A HBEGF SPHK1 TRAF3 TMEM186 DUSP8 VANGL2 MGARP DHCR7 APOC2 SYT17 TMPRSS4 CXCL16 VAMP5 BSND GIPC1 LRG1 SEC14L2 PAK1 NIN up
## PIGF_UP.V1_UP 0.0013831 0.0097222 -0.4463799 -2.102926 0 181 STAM2 CREB1 MAP2K4 TRIP11 DMTF1 PAPOLA ZNF451 TTC37 STXBP3 THOC2 F11 PLA2G4A ZNF268 PTGS2 GMFB PGAP1 ZNF117 CDC27 AHCYL2 TMED5 BCLAF1 IREB2 MTM1 BAZ2B XIST DNAJC3 SREK1 ITGA2 RPGR CEP350 PEX1 PHF3 IL6ST ZC3H14 CCPG1 STON1 MKLN1 ASCC3 ABCA8 IRAK1BP1 TDRD3 REV3L LRRC17 PPIG HSPA13 UFL1 CRYZ SUCLA2 CPA3 RUNX1T1 MICU2 DHX29 MMRN1 LGALS8 RIF1 DCP2 MMP10 SACS MIPEP SPRYD7 STK38L SLC38A6 CLEC2B EIF2S3 UGP2 AGL TSPAN8 MBTPS2 COL8A1 SGMS1 PRKACB TWISTNB STAU2 TGFBR3 SOCS5 CEBPZ TWF1 FABP4 SYNE2 NEK1 NECAP1 NAT1 GLRB NEK7 GRB14 ANGPT2 NAP1L3 KIF5B SP3 RAP1A NUCB2 CD2AP AKAP9 MTF2 SCAF11 CRYBG3 ABCE1 NUP155 GGCX HSD17B4 SLC4A7 IL1RL1 down
## VEGF_A_UP.V1_UP 0.0035211 0.0097222 0.4029177 2.100993 0 177 HMCES TCEA2 UBE2L6 RHBDD3 CLIP3 DDIT4 CIC ETFB CCS NFKBIE DYRK1B DDIT3 CALCOCO1 PPFIA4 FEV SH3BP2 CORO2B ZNF205 KIAA0930 CAMP KCNC3 IRF5 HDAC5 RFNG MYO1F PLTP P2RX4 ADORA2A COLQ FCGR2B GDF11 TNFSF12 SUPT6H HOXB5 AKAP3 NCF2 KMT2D TRAF1 NFKB2 RBMX2 IRF9 DENND3 TM7SF2 UBA7 RELB NKG7 COL11A2 TMEM8B FPGS LY6E APOBEC3G ZNF76 KIAA0556 OPTN PPP6R2 KCNMB1 EMILIN1 AMOT RGS3 LYRM9 PTPRJ NINJ1 PYY IL32 SMG6 DUSP8 MN1 CCDC57 CLCN6 ARL4C IFT140 CD5 TP53I11 ITGB4 INPP5J LHX2 PSMB8 CD19 CABP1 AKR1B10 EPHX1 ZC3H7B up
## CYCLIN_D1_KE_.V1_UP 0.0035211 0.0097222 0.3967043 2.072641 0 178 NFE2 CDKN2A HK3 ZYX SUPT5H THOP1 POLD1 PKN1 KCTD2 PLOD1 SNX17 PFKL KAT5 ZNF787 KIF22 PPP5C S100A2 DRD5 PLCB2 CHRNB4 AXIN1 KCNAB2 PCGF2 MED24 COASY GCHFR GNAI2 COX7A1 TRIO TROAP LTBR LMF2 EIF5A PPM1F COX17 GPT CCL20 TFAP2A CENPB CDR2 NRG1 TRAF1 ST3GAL4 CTBP1 PMPCA CELA2B MAD1L1 DNASE2 HOXC5 RRAS PLK3 MAT1A APOC1 HBA2 PHKG2 RGS3 TSC2 CD52 MAN2A2 RASSF7 SCAP FOSL2 KLK6 CDR2L BATF DMWD FOXK2 GOT1 TRIM25 PTPRH up
## PRC2_EZH2_UP.V1_DN 0.0036364 0.0097222 0.3986514 2.069811 0 173 RDH5 MCM2 ACTC1 HAUS5 CDC45 TPD52L1 NFE2 THOP1 CDT1 GNA15 TACC3 KCTD2 HCFC1R1 PCK2 KCND1 LRRC61 LMNB1 RAD54L DEF6 ZNF219 PSRC1 PDCD4-AS1 IQCC CORO1A KIF4A ZNF446 MXD3 GALR3 DSCC1 KNTC1 AURKB OIP5 NCAPH CDC25A BUB1 DDB2 NUP37 MCM10 ELP6 RFC4 MYBL2 PRIM1 FUT7 PLCD1 HOXA10 GRM4 EZH2 HMOX1 KIF15 ZNF574 NPAS1 SOGA1 TRPM4 EPHX2 MEFV HMMR CDH17 OCEL1 MED18 FOSL2 WDR76 APLP1 GAS1 DLGAP5 HJURP PILRB SYN1 SLC8A1 TTK HOXD11 CENPF LRRC20 ECT2 GNB1L PAN2 CEBPE XRCC3 PITX1 up
## RPS14_DN.V1_DN 0.0035971 0.0097222 0.3975630 2.060991 0 172 MCM5 TK1 ISOC2 INCENP MRPL12 POLD1 ESPL1 TPRA1 ORC1 PLK1 MRTO4 NEFH PRC1 IL15RA KIF2C CAD HMGN5 CDC20 KIF20A AOC2 TRIM29 ATAD2 CDC6 ZNHIT2 MKI67 PC NCAPH TUBG1 CDR2 CBS ALAD ERCC2 MCM10 PES1 GINS2 MYBL2 RPUSD2 RPS28 GCDH NLE1 PSAT1 LARS2 CCNB2 AGFG2 TBRG4 GAL BAG3 PBK KIF15 KIF5A KIF23 CLCN4 RRS1 PCSK7 SRM FBXO5 SIRT4 B3GALNT1 IPO4 MYO19 SPHK1 CHAC1 SLC29A2 TRIP13 CENPE S100A3 DLGAP5 PCK1 CRMP1 MRPS2 ARHGAP11A FICD LRRC20 ECT2 TUBB2B STEAP3 GPATCH4 SLC25A21 up
## PIGF_UP.V1_DN 0.0036232 0.0097222 0.3990303 2.057481 0 169 NOS2 CDKN2C CAMK2B POU2F3 ZFR2 NUCB1 SH3BP1 PXN ERF MYOG PRPF19 PPFIA4 TOP3B OBSCN S100A4 KCNC3 TAOK2 KCNAB2 RFNG MYO1F CDC20 ZNF646 ALOX5AP FOXG1 GPR182 HOMER2 TRIO TROAP C22orf24 SRCAP PKP3 CCDC9 SLC6A15 TNFSF12 KMT2D DPF1 PDE1B NFKB2 GFRA2 SPN MAST1 IRF2BP1 CLASRP CLPTM1 RELB DHX34 COL11A2 PDE6A SNX29 LY6E NFASC ZFHX2 TTLL3 APOC1 AURKC KCNN4 MAP1A BCAM SLC29A2 SMARCD1 SLC30A10 ACAT2 CTSW GRM2 SMG6 DOLPP1 ACTL6B IGFBP5 CD5 SHBG PTPRH VGF ITGB4 EFNA5 GYPC TNFAIP3 CEBPA NELL2 up
## MYC_UP.V1_UP 0.0033333 0.0097222 0.3971316 2.029835 0 157 UNG TSSC4 WDR83 PRR7 ISOC2 DUSP2 MTFP1 CCDC124 CHCHD10 MRTO4 NEFH PUS1 SAC3D1 HSPA6 LAS1L LRRC61 TMEM201 MNT SLC25A22 QTRT1 KLF16 C19orf48 NOC4L EXOSC5 DENND2D DPP7 VPS9D1 C20orf27 AMPD2 RPTOR SMYD5 SLC6A15 ALG3 DCAF4 ZNF593 REPIN1 PES1 TRMT1 MMP25 B3GNTL1 DCTPP1 RPUSD4 NOP14 SPATC1L NLE1 SCFD2 USE1 NR2C2AP OAF RRP9 MICU1 TOP1MT ECE2 AGPAT3 PCOLCE2 GLRX5 IPO4 RRP12 UTP14A up
## HOXA9_DN.V1_DN 0.0035714 0.0097222 0.3887233 2.024524 0 176 RBM38 CDC45 MPI HOXA9 MT1G GINS3 CDT1 CD300A FANCG ECH1 GADD45GIP1 ORC1 VEGFB TMCO6 NCAPD2 HSPA6 ATF5 SMAGP MEN1 ALDOC GINS4 ADM HMGN5 NME4 HOXA5 SLC1A5 SLC2A5 PHLPP1 EXOSC5 RNASEH2A TEX264 NPTX2 WBP2 PARVB FCGR2B FADS1 ATAD2 CDC6 SREBF1 TMEM106C CBS MCM10 FANCI ZNF395 ACPP ITGB5 SP1 SV2A CEP55 TOMM34 TRIB3 CYP51A1 FADS2 RAB33A PLK4 GINS1 PFAS HHEX SLC29A2 MEX3D CST7 SPON2 FCGR2C KCTD15 DHCR7 FCGR2A TES SPP1 ARHGAP11A SCAMP4 TAF4B MVD COL9A3 ELOVL6 HILPDA SLC29A1 RGS16 PSIP1 RFWD3 TBL1XR1 APOBEC3B TIPIN TEX15 COCH HELLS up
## IL2_UP.V1_UP 0.0036630 0.0097222 0.3892980 2.004163 0 170 IL10 BTC VSNL1 PRR7 DUSP2 RSPH6A SIGLEC9 CCDC85B PUS1 WDR62 OSM TNFRSF1B IL1A SLC1A5 MFSD12 HK2 SLC34A1 GALNT8 HOXA11 DHRS3 JUNB ALDH4A1 PRAF2 GPT LRP8 FLT3LG CDC25A TRMU ZBTB32 RPP25 PTPN7 PIM1 RHBDF2 RAC3 GABARAPL3 TNFRSF4 SOCS1 DGKG TNFRSF12A CAPN10 STX11 SPATA2L VDR TNFRSF9 CDCP1 FOSL1 RGS3 CD52 SPHK1 SLC29A2 FOSL2 CDH3 ADAM19 up
## CRX_NRL_DN.V1_UP 0.0031646 0.0097222 0.4064185 1.989675 0 123 ANKRD33B CDKN2C PPARGC1B SLC16A3 REC8 DOHH CROCC SSBP4 GUCA1B UBXN11 PTPN18 ZDHHC12 TNIP2 SAP30 TNNT1 DHRS3 PDIA5 BST1 EPS8L1 CABP4 SYTL1 ZC3H3 CDR2 NXNL2 RNF123 HCLS1 NRL MYO7A PAQR4 PDE6A AHRR ST3GAL1 RNF207 SNTA1 TTC39C DPF3 MOGAT1 BUB1B KCNN4 DRD4 DIAPH3 SLC29A2 PROSER2 up
## MTOR_UP.V1_UP 0.0033784 0.0097222 0.3934852 1.987175 0 153 KCNE3 MCM5 FOXI1 SMTNL1 TMEM40 COMTD1 ISYNA1 NTSR1 GSS PFKP BID CCAR2 UHRF1 SLC2A1 NEIL3 BST2 ALDOC MCM6 FAM131A IL27RA CCDC86 CDC20 CPPED1 KRBA1 IFI35 SLC41A3 PRAF2 KCNK4 HIVEP3 DLG4 H6PD NQO2 BDH1 STMN1 CD300LD PSAT1 IFI30 FGFBP1 HMOX1 TNFRSF12A ABCA2 RRM2 TMEM106A CYP51A1 UBE2C ANKRD33 TARS2 TG PPAN SIGLEC1 CDH17 GABRG2 PCYT2 MGARP USP18 CTRB1 TFRC DHCR7 MTHFD1 CYP26A1 TMPRSS4 OAS2 up
## MEL18_DN.V1_UP 0.0031646 0.0097222 0.3969551 1.965201 0 129 CHST3 CSF1 DDIT4 FJX1 FADS3 MT1F SUN2 TMEM51 PLXNA1 TNFSF9 ADM ZC3H12A COL7A1 GDF5 SLC1A5 AGRN CSF2 C2CD2L ASPH STC2 CLSPN TNFRSF8 CHST11 DDX11 GAL SLC6A9 CLDN1 SLC1A4 INHBE VEGFA TNFRSF9 CDCP1 FOSL1 ATP13A2 HBEGF ITGA5 LAMB3 ADAM19 SLC7A5 TYRO3 LCP1 ARL4C PLAUR SPP1 ABCC5 PIEZO1 STEAP3 HS3ST3A1 ITGA3 VLDLR LRIG1 ENTPD6 KIF21B SLC29A1 CHST2 SLC7A11 up
## ESC_J1_UP_LATE.V1_DN 0.0036630 0.0097222 0.3791966 1.963645 0 174 HMCES ZNF428 WDR83 HCK PIH1D1 GYS1 ECH1 NGFR POLE NEFH LMNB2 VPS33B CLTB ATG2A EVC SMARCD3 POLR3K CORO1A SLC1A5 PHLDA2 ITGB7 DDX49 CIRBP PIK3R4 PRMT6 ENDOG HOOK2 TRAIP MAPK7 TFEB MVK PHB DBR1 ATPAF2 DOC2A TGM1 AMH MSRB2 RPP25 LCK ARMC6 MED11 GNG3 ACTN3 NNAT RRP9 DNASE2 NPHS1 RASGRP2 PCOLCE2 DDX27 MTG2 TCEA3 RRP12 MRPL18 HARS2 TRH up
## ESC_J1_UP_EARLY.V1_UP 0.0033223 0.0097222 0.3865724 1.952893 0 151 MPP2 SLC8B1 ASCL2 CRELD1 CD82 NME3 PTPRCAP GADD45G P4HA1 TYMP RAB3IL1 TPGS1 ADM ADTRP CD68 P2RX4 SIL1 COL26A1 TRAFD1 CPPED1 CYP2S1 DPP7 TEX264 COLQ PHF21A NLRP3 SOX15 GPT HIVEP3 DIDO1 BCL2L2 TMEM106C NAGA P4HA2 PCTP NEK2 NR1H3 CHRNB1 FMNL3 NAGS CPT1B ALX3 ANGPTL7 LOXL2 RPL22 ECE2 ABCG1 NARF TEX101 AUP1 DHRS7 CD33 FOSL1 NR1D1 IL15 FXYD3 up
fgsea_plot(fgsea_res$res_c7, pathways_title='C7 immunologic', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ----------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0040486 0.0070876 0.7207604 3.764216 0 187 SRSF9 RBM42 HNRNPM TSSC4 HRAS PAF1 PIN1 ABCF3 NFKBIB DGKZ IRF3 THAP7 HMG20B CFL1 TAF10 COPG1 TSPAN14 BANF1 SSRP1 CCS ARF5 BRMS1 TSR3 RAB1B GPS2 U2AF2 TMED9 TACC3 MRPL12 HTRA2 ARPC4 SPINT2 AIP GADD45GIP1 AMBRA1 ADRM1 NELFB SART1 DRAP1 CCDC85B C9orf16 TBL3 PTPRCAP PFN1 ERP29 PRPF19 POLR2E STARD3 AURKAIP1 SAC3D1 PTMA SIPA1 NONO VPS51 AAMP TMEM259 PDCD4-AS1 UBE2M SLC25A22 QTRT1 NADSYN1 LIMD2 NDUFC1 CDC37 PSMB10 WDR74 CORO1A E4F1 UBE2S ZBTB17 SH3GLB2 GZMM CDK9 TRIM28 MFSD10 SDF2L1 SLC2A4RG WDR18 DAZAP1 ABHD17A SAFB TAF1C SNRPF XAB2 DNAJC17 NOC2L PEX5 PDAP1 VPS9D1 SAFB2 SMARCD2 UBN1 FBXO41 TNFRSF14 EDF1 ZNF512B SREBF1 APBA3 SNRNP70 SNF8 GSN SF3A2 CLPTM1 RALY DCAF15 SIGIRR ANAPC2 GCDH RPLP2 RALGDS CDCA4 PTBP1 THOC6 PFDN2 CD7 STK25 EEF1D FUS PDIA4 EXOC7 RPL36 RRS1 PPP6R2 CD81 RASGRP2 ATP13A1 up
## GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0038023 0.0070876 0.6799831 3.577441 0 181 SRSF9 HNRNPM C12orf10 HRAS RPN1 DGKZ HMG20B R3HCC1 CFL1 TAF10 CORO1B COPG1 TSPAN14 SSRP1 TSR3 GPS2 CALM3 U2AF2 TMED9 MRPL12 PCBP1 ARPC4 PKN1 ADRM1 DEAF1 DOK2 SART1 DRAP1 CCDC85B C9orf16 FBXL15 PTPRCAP PFN1 NDUFS8 ERP29 POLR2E STARD3 AURKAIP1 SAC3D1 FCHO1 COTL1 ECSIT MYH9 NONO RNF126 GTF2F1 VPS51 RNF19B NADSYN1 LIMD2 NDUFC1 CDC37 PSMB10 GID8 UBE2S SH3GLB2 GZMM TGFB1 MFNG ELF4 PPP1R14B ZNF580 MFSD10 CHCHD3 DDX49 CBX4 LRRC47 WDR18 DAZAP1 MINK1 SAFB SNRPF XAB2 MAP2K2 PDAP1 ILVBL SAFB2 SMARCD2 RDH14 CAPN15 COX5A FBXO41 BECN1 TNFRSF14 EDF1 ZNF512B SNF8 APRT GSN HNRNPUL1 SF3A2 MSN BCL7C RALY RPLP2 CDCA4 EIF3F WDR45 RBCK1 PTBP1 YBX1 THOC6 PFDN2 STK25 HMOX1 PDIA4 PABPN1 AHCY CD81 RASGRP2 PMS2P2 MVP up
## GSE9601_UNTREATED_VS_PI3K_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_UP 0.0038023 0.0070876 0.6870659 3.548634 0 162 FRMD8 SHKBP1 DDX54 TSSC4 ARL6IP4 IRF3 THAP7 PPP1R9B MBD3 NOSIP CSF1 RNASEH2C FKBP8 SSRP1 RAB1B OSBPL5 SCPEP1 DNMT1 CAPG NFKBIE MEA1 MED15 HMGN2 SF3B2 PSMC4 SIRT7 DDX41 PYCARD TNIP1 SDF4 PTPRS NDUFS8 MIIP MAP4K2 SIPA1 LMNB1 CXXC1 MYH9 ARHGDIA GTF2F1 TLN1 MCM3 TICRR CCDC12 TUBGCP2 KIF2C PSMB10 CORO1A EHD4 RCC2 MYO1F PREX1 SERF2 CENPW IGF2R MAP2K2 NCAPD3 PSMB4 TMCO4 SASH3 TFEB SRRT RGS14 WBP1 ANKRD11 POLR2L BSG TPX2 SF3A3 CSNK1G2 NDUFS5 BIRC5 B4GALT7 CDCA8 FMNL1 TRAF1 CYBA CCDC97 IRF9 PRRC2B RPL38 RAB4B MYO18A PIM1 RPL41 E2F7 FLII BDH1 RELB HNRNPL CTBP1 RBCK1 GIMAP7 OS9 YBX1 MAD1L1 IRF1 BRCA1 EXOC7 RPL18 up
## GSE45837_WT_VS_GFI1_KO_PDC_DN 0.0038610 0.0070876 0.6681285 3.492893 0 180 ZNF428 NDUFS7 TWF2 MCM5 PIN1 ARL6IP4 MRPS11 PSMC5 EIF3K MPI R3HCC1 NUDT1 MRPL23 MZT2B ETFB SNRNP25 MRPS34 NPM3 ARF5 PSMD13 GANAB SUN2 PFKP ECI1 MZT2A MRPL40 HMGN2 PRMT1 DRAP1 SHMT2 CCT7 UQCR11 ERP29 POLR2F COX6B1 DNPH1 CD2BP2 GMFG BST2 UBE2Z ECSIT GRHPR FASTK RFXANK AAMP SOD1 POLR2I PLEKHJ1 ENSA UBL5 ETHE1 ARPC1B COX8A CAPZB HSPB1 PSMD8 NUMA1 MRPS16 CTDNEP1 DDX49 EBNA1BP2 STOML2 PSMD9 SNRPF PDCD5 NME1 PSMB6 PSMD4 RAN LSM7 UQCRH EIF3I SNRNP35 ANXA11 SNRPD2 COX5A BANP SPECC1L EDF1 PARL TOR3A COPS6 MPG PIM1 LMAN2 CLASRP EPS8L2 CLPTM1 DFFB NDUFS6 SAE1 MPDU1 SET RALGDS EIF3F RBCK1 UCKL1 RANGRF NIPSNAP1 VOPP1 NDUFA2 FUS DYNLRB1 TOE1 TRAPPC2L AHCY AUP1 RASGRP2 TRADD XRCC6 KCNN4 DECR2 NDUFA7 EEF2 DDT OCEL1 TCF20 DBI CDC42SE1 CBX7 IGBP1 up
## GSE16385_MONOCYTE_VS_12H_IL4_TREATED_MACROPHAGE_DN 0.0039370 0.0070876 0.6446246 3.373492 0 183 JOSD2 ABCB9 HMG20B RAB35 RPS6KA4 NPM3 ABI3 ZBTB48 GPS2 CHD4 XRCC1 UTP3 MAP3K11 PHRF1 ZFAND2B SIRT2 PACSIN1 NELFB USP11 STX4 CLCN7 PPP1R12C AKT1S1 ERP29 POLRMT DDB1 ZNF384 MIIP MAP4K2 FCHO1 RNF31 LMNB1 COTL1 DENND4B TRIM11 FASTK TLN1 TMEM259 WHAMM TATDN2 STX5 SH2B1 MLLT6 RNF19B ABHD8 HDAC7 NCLN CORO1A ALDH2 ATXN2L ANKRD54 IL27RA TSC22D4 CAPZB TESK1 AP3D1 PPP1R37 STRN4 LIPE LRP10 ZNF777 PIK3R4 TBC1D9B TRABD LMF2 ARID1A MAPK8IP3 GLYR1 GUCD1 FAM20A IFFO1 PIK3R5 WBP1 LASP1 DCLK2 ZNF653 CIZ1 MBP PQBP1 SNRNP70 LMAN2L CCDC97 MOB3A HCLS1 UBA7 LRSAM1 CHRNB1 TUFM CYTH1 ACPP GNB2 RAPGEF3 ACAP1 UCKL1 RPS6KB2 GALT SNAPC4 MND1 FAM193B TOMM34 EGLN2 ABCA7 STRIP1 AUP1 up
## GSE22589_HEALTHY_VS_SIV_INFECTED_DC_UP 0.0038168 0.0070876 0.6389657 3.337983 0 179 KCNE3 RILPL1 TIMELESS TMEM160 DDX23 ABI3 DOHH DHRS13 GPS2 MRPL12 POLD1 CLK3 BTBD2 PTK2B CCDC88B GADD45GIP1 UBAC1 DAPK3 SDHAF1 GRK6 TCIRG1 FERMT3 TELO2 PTPN18 STUB1 PARK7 TUBA1B TIMM13 PICK1 SLC2A1 SLC7A1 LMNB2 SIPA1 NCAPH2 SNORD104 LAMTOR1 FES NDUFB10 JMJD6 ARRB2 VPS51 PSRC1 POLR2I POLR2J ADM CYTH4 MED12 MRPL17 ANKRD54 HSPB1 HAGHL MEGF8 ANKRD13D STAT6 CHCHD5 NFIC HK2 INF2 FKBP15 NOL12 CDK5RAP3 NR1H2 JUN LTBR ZFHX3 FGD2 RPL13 DNAJB1 NLRP3 PSTPIP1 RGS14 MATK SLC7A6OS NDUFS5 DBNL LLGL1 SLC6A13 SREBF1 ZNF593 AGAP3 CIITA MPG PPP1R16A TUBB6 PARP2 MLLT1 DVL1 SIGIRR EIF4G3 ELAC2 DNAJC4 TRIP6 MT1E DDX11 ATF4 VRK3 SLC12A9 IRF1 IL4R RPL36 MAPKAPK5 CARD11 SAPCD2 XRCC6 LRWD1 up
## GSE369_PRE_VS_POST_IL6_INJECTION_SOCS3_KO_LIVER_DN 0.0040486 0.0070876 0.6360914 3.322027 0 187 ZNF428 LZTR1 BLVRB MCM5 RBP1 TADA3 DGKZ RHBDD3 R3HCC1 PRKCSH STXBP2 ZYX ANAPC15 PPIL2 GABARAP SUPT5H EPHB2 ZBTB48 STAB1 RGS19 NUCB1 NAGPA TSR3 UBTF BTBD2 EIF2B5 POLE MLF2 MAN2C1 MAP3K11 SH3GL1 MEA1 SART1 RHOG PLD3 ARAP1 CAMK1 ERP29 CSF1R VAV1 DDB1 ZFPL1 PIP5K1C DENND4B ARRB2 CACTIN TMEM259 TBXAS1 TXN2 PLCB3 NCF4 KCNAB2 TBC1D2B RAB11B MEGF8 TRIM28 MAN2B1 RANGAP1 AGRN MYO1F MAZ MYO9B RTN1 RNF40 LRP10 MAP2K2 TBC1D9B PRPF6 CD4 GNPDA1 LTBR FCGBP GRN WBP2 SLC4A2 IFFO1 GDF11 BSG SGSH MAPK3 HADHA SUPT6H ERAL1 IDH2 IL10RB RAB4B SNN CLPTM1 CLEC11A ATP6V0C ARFIP2 GCDH ARSA TSPAN4 OS9 FASN PFKFB3 GSTP1 HIRA GBF1 GDI1 PCSK7 FCGRT FOLR2 WBP1L CMTR1 TRADD up
## GSE9988_LPS_VS_VEHICLE_TREATED_MONOCYTE_DN 0.0040161 0.0070876 0.6265125 3.293124 0 191 UNC45A ZNF740 TWF2 DGKZ PPP1R9B RAP2B SERTAD3 GABARAP PSAP FRAT2 RGS19 ZNF467 TACC3 MAP7D1 PCBP1 APOBR CSK PFKFB4 UBAC1 PRR13 SH3GL1 LYL1 DOK2 PLIN3 RHOG ARAP1 SETD1B CSF1R PPP1CA STK11 ATF5 PIP5K1C PRELID1 COTL1 PGP TTC7A TNFAIP8L2 NELFA MTCH1 NCKAP5L TCHP ZNF688 ZNF511 NLRP12 LGALS1 CORO1A ORAI3 ARPC1B TNFRSF1A IL27RA TRAPPC12 ARHGAP30 CDC34 FAM214B ANKRD13D VMO1 PLEKHO2 MYO1F TYROBP NFIC ARHGAP22 FRAT1 NUDT16L1 PHF23 ATXN7L3 GRN SASH3 ATG9A RPS6KA1 TFEB TGFBI KLHDC3 IFFO1 CALHM2 MLXIP RGS12 CCR2 CENPB MAST3 RARA CTDSP1 MPG ARHGAP1 TMEM101 MAP3K3 GLTP PIK3CD FAM78A SDHA NAGS SPIDR PLXNB2 IFI30 NCOR2 USP19 GSTP1 APBB1IP BRD3 LAPTM5 WBP1L CMTM3 GLUL RUNX3 THAP11 up
## GSE14415_NATURAL_TREG_VS_TCONV_DN 0.0039216 0.0070876 0.6340164 3.287514 0 173 MCM2 ROM1 MCM5 HMGB2 CDC45 TK1 CENPM TACC3 PTMS CHTF18 SCAF1 EHBP1L1 SPC24 PLK1 LIG1 LSP1 PYCARD PRC1 CENPN UHRF1 NCAPD2 CHEK1 MCM7 AUNIP LMNB1 NEIL3 RAD54L ACTB MCM3 MTCH1 ITGAM ATP2A2 RAD51 KIF4A ASF1B CHAF1B NCKIPSD MCM4 FKBP2 CTSC DISP2 ANP32B GSR CENPP GNAI2 RRM1 CCNA2 SLC41A3 CKAP2L ASXL1 TPX2 RAB39A NCAPH BIRC5 CDCA8 CLSPN CDC25C HNRNPUL1 GZMB BUB1 ZBTB32 CNIH2 TOPBP1 SPN ABR MSN ITGAX ARF6 HCLS1 KIF11 SPAG5 ABRACL MRPL34 STMN1 HOXB2 BLM PRR11 CENPH CCNB2 AGFG2 CTSD ESCO2 CEP55 PBK BRCA1 KIF15 FAM117A KIF23 RRM2 DUT KDM4A FBXO5 NCAPG BUB1B ASPM GINS1 IQGAP3 CKM HMMR SLC43A3 PROSER2 TOP2A CENPE PDLIM4 DLGAP5 TEAD3 SMC2 AURKA GPR55 up
## GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_OLD_DN 0.0038023 0.0070876 0.6177182 3.249861 0 181 RBBP8 UNG MYL6B COMMD4 MCM2 KEAP1 MCM5 TIMELESS CDK2AP1 MRPL11 EMC9 TK1 TIMM8B NUDT1 FEN1 SNRNP25 CENPM FAH FADD FANCG ESPL1 PSMD2 MFSD5 HMGN2 FAM50B TUBA1B PGAM1 MIS18A MCM7 ACOT7 CYC1 PCCB NAP1L4 NCAPG2 RAD51 KIF4A MCM4 EBNA1BP2 RACGAP1 SNUPN CDC20 RNASEH2A KIF20A PSMB5 NME1 TUBA1C GNPDA1 SMCO4 HNRNPAB FOXM1 DPP3 CCNB1 CCNA2 GSTO1 CORO1C AURKB CCDC51 CDC6 MKI67 TPX2 OIP5 NUP93 FANCE SEPHS2 NCAPH TUBG1 TMEM106C MCM10 RFC4 KIF11 BDH1 SPAG5 GINS2 ZWINT FANCI STMN1 BLM CCNE1 TYMS CCNB2 NDUFS2 CEP55 KIF23 CKAP5 RRM2 UBE2C VDR CENPA DTL NCAPG RAB33A CSTF2 BUB1B PLK4 ASPM RAD51D MED8 MRPL18 IL2RA HMMR SLC43A3 TRIP13 TOP2A NUSAP1 DLGAP5 HJURP CDK4 SMC2 AURKA SRSF1 MELK GBP2 MTHFD1 GOT1 TMPO CENPF HAUS4 ALAS1 PSMB2 TUBB2B up
## GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_DN 0.0040486 0.0070876 0.6190736 3.233151 0 187 RBBP8 MYL6B MCM2 MCM5 CDC45 CDK2AP1 TK1 FEN1 GINS3 CENPM POLA2 FAH CCL17 FANCG ESPL1 CHAF1A TALDO1 LIG1 PCK2 TUBA1B PGAM1 TIMM13 SAC3D1 MCM7 LMNB2 ACOT7 RAD54L TYMP FIBP UMPS ZNF282 TXLNA PPCDC KIF2C NCAPG2 ALDH2 RAD51 KIF4A MCM4 TMEM140 RACGAP1 CDC20 MRPL20 KIF20A NME1 TUBA1C DTYMK CCNB1 AURKB CCDC51 KIF18B MKI67 TPX2 NCAPH BIRC5 YWHAH TUBG1 CDCA8 TMEM106C CDC25C STIP1 PTPN7 MCM10 HMBS RFC4 TUBB6 IMMT KIF11 DCTPP1 FANCA SPAG5 GINS2 STMN1 BLM GALE CCNE1 TYMS IFI30 THOC6 SPATA5L1 CCNB2 CEP55 BRCA1 KIF23 CKAP5 DNAJB6 RRM2 DUT UBE2C VDR CENPA DTL TTI2 NCAPG WDR77 ASPM RAD51D PFAS IL2RA HMMR SLC43A3 TRIP13 TOP2A TXN CENPE NUSAP1 HJURP BATF SRSF1 PXMP2 SLC6A12 TJP2 PALB2 IL12RB2 ALAS1 CKS2 BATF3 up
## GSE3337_CTRL_VS_16H_IFNG_IN_CD8POS_DC_DN 0.0038610 0.0070876 0.6079605 3.178342 0 180 FRMD8 MCM2 TRIM21 UBE2L6 TMEM160 PSME2 FKBP8 PSME1 TOMM40 POU6F1 POLA2 EMC10 NDUFV1 CDT1 CAPN1 OSBPL5 CUEDC2 NUP62 PTK2B ADRM1 NAA40 GGA1 BCKDK TANGO2 UHRF1 SMARCB1 CAPNS1 MCM7 OGFR SMAGP PML TSPO SIVA1 MNT RNF19B ABHD8 CPOX PSMB10 SERTAD1 MFNG NOC4L RCC2 CDC20 KANSL2 GPS1 ECE1 TAF1C RNASEH2A ARPC5L UNC119 PDAP1 PSMD4 FAM110A RAN IL18BP UPP1 BST1 PLOD3 SLCO3A1 POLR2L LPP-AS2 PQBP1 AP1S1 HIP1R LYPLA2 NUP85 ABR PIM1 BCL7C HCLS1 HSD3B7 UBA7 RAD23B DVL1 LYSMD1 CHMP1B CCND3 CD37 SOCS1 MAP4K1 PFKFB3 FUS IRF1 INPP5B EGLN2 CASP9 CXCR2 IL12RB1 KIF1B TFIP11 STIL GBP7 C3 NOTCH1 NAA38 PSMC3IP POLDIP3 CDK2AP2 EXTL3 GLIPR2 CYFIP2 GBP2 CXCR3 TNFAIP2 PAFAH1B3 BUD31 SF3B3 up
## GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_OLD_DN 0.0040486 0.0070876 0.6069118 3.176647 0 186 UNG MYL6B MCM2 KEAP1 RANBP1 CDK2AP1 MRPL11 EMC9 TK1 NUDT1 FEN1 GINS3 GAPDH CENPM ATOX1 FAH MRPL12 FANCG RFC5 ESPL1 PSMD2 GADD45GIP1 POLR2H TALDO1 PCK2 TUBA1B PGAM1 CHEK1 CD2BP2 MCM7 LMNB2 ACOT7 TYMP CYC1 PPM1G GCLM KIF2C POLR3K NCAPG2 ALDH2 RAD51 KIF4A TNS3 MCM4 EBNA1BP2 RACGAP1 SNUPN RNASEH2A NUDC KIF20A PSMB5 NME1 TUBA1C CSTA DPP3 PSMB6 CCNB1 GSTO1 AURKB PHB CDC6 TPX2 LRRC42 SEPHS2 NCAPH TUBG1 TMEM106C CDC25A NUP37 MSRB2 STIP1 MCM10 RFC4 TUBB6 KIF11 BDH1 DCTPP1 SPAG5 GINS2 ZWINT FANCI STMN1 PRIM1 BLM TYMS CCNB2 CEP55 KIF15 CKAP5 RAD51AP1 RRM2 VDR CENPA DTL NCAPG CSTF2 BUB1B ASPM MRPL18 IL2RA HMMR SLC43A3 TRIP13 TRAP1 TOP2A WDR76 DLGAP5 HJURP CDK4 SMC2 AURKA SLC6A12 MELK MTHFD1 ANPEP TMPO CENPF ALAS1 CKS2 up
## GSE14415_INDUCED_TREG_VS_TCONV_UP 0.0038023 0.0070876 0.6116746 3.158913 0 161 CDKN2C ROM1 RANBP1 CDC45 CDK2AP1 NUDT1 HIRIP3 ETFB SCARB1 CALM3 PTMS PCBP1 RFC5 CHTF18 SPC24 PLK1 SHMT2 PYCARD CENPN ERP29 POLQ MCM7 KIF22 NEIL3 TUBGCP2 LGALS1 SNRPA POLR3K RAD51 ASF1B MXD3 CDC20 PSMD3 DSCC1 NME1 CENPP TROAP DDX39A CCNA2 RAN DDOST TRAIP CKAP2L RPS6KA1 UBE2L3 AURKB AP2A2 UBE2I KIF18B MKI67 CS BIRC5 CDCA8 CDC25C GZMB BUB1 ZBTB32 NUP37 PHGDH MCM10 GLTP RCC1 RIPK3 E2F7 WIZ SPAG5 STMN1 PRIM1 PLXNB2 PSAT1 CCNB2 POLL LY6E PBK KIF15 GMNN RAD51AP1 RRM2 DUT MTX1 TUBB4B CEP72 FBXO5 HAVCR2 GINS1 MRPL18 HMMR TRIP13 up
## GSE24574_BCL6_HIGH_VS_LOW_TFH_CD4_TCELL_DN 0.0040486 0.0070876 0.5999285 3.140095 0 186 AP2S1 UNG MYL6B MCM5 CDC45 PKM PSMC3 NPC1 STXBP2 MRPL23 VCP BCAT2 ETFB TOMM40 NPM3 PLRG1 SSRP1 FAH FADD THOP1 CDT1 DNMT1 ECI1 ORC1 CHAF1A OSGEP HMGN2 PCK2 COMT CAMK1 AHCYL1 LMNB2 PARP1 RAD54L GCLM TXLNA LGALS1 LAG3 KIF2C CPOX PCCB PGD SNRPA ETHE1 COX8A PCBD1 GZMH MCM4 FKBP2 MFSD10 ENO1 NME1 CCNB1 EIF3I TRIP10 AURKB HNRNPA0 FSCN1 CDC6 MKI67 TPX2 OIP5 PRDX1 TMEM106C IDH2 CDC25C TRAF1 HMGN4 TIAM1 PHGDH LDHA NEK2 COX6A1 NKG7 FANCI DFFA PRIM1 CCNE1 NIPSNAP1 UBA1 SIT1 ATF1 ECHS1 PMVK GBP1 CKAP5 ACTA1 PDIA6 HDGF STAMBP GINS1 LCP2 PFAS BCL2A1 SRD5A1 POLD2 TRAP1 CST7 TOP2A MAPKAPK3 DBI CSTB DLGAP5 up
## GSE17301_CTRL_VS_48H_ACD3_ACD28_IFNA2_STIM_CD8_TCELL_DN 0.0038610 0.0070876 0.6059012 3.139941 0 169 CDKN2C MRPL28 AAAS HAUS5 HMGB2 ITGA7 TK1 CIC RASSF1 PKMYT1 TOMM40 CENPM SCARB1 DOHH ATP2A1 DBF4B PTGES2 GSS RHOT2 NEFH HMGN2 NAA40 PTDSS2 WDR62 CC2D1A KPTN TUT1 STK11 NCAPH2 EPN1 LRRC61 RAD54L FASTK HDAC7 IQCC POLG PTTG1 CEP164 HSPBP1 ASF1B SLC1A5 MXD3 FKBP4 ZNF646 GTSE1 CEP85 CPPED1 CNPY4 RECQL4 CCNF FOXM1 TROAP MAP2K7 LMF2 TRAIP RTEL1 ZNF500 MICAL3 AKAP3 CLSPN DENND3 SPPL2B E2F1 FGR AKIP1 GPR19 LIMK2 ETV7 MYBL2 SH3GL3 RAG1 CD72 RAC3 HOXA7 TYMS FPGS CCNB2 HOXA10 SLC1A4 BRCA1 RRM2 CAPN10 GFI1 FADS2 TTLL3 SLC25A10 DNMT3B CDK5RAP2 up
## GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_YOUNG_DN 0.0039370 0.0070876 0.5972189 3.125405 0 183 RBBP8 TIMM10 MYL6B MCM2 MCM5 CDC45 MYL6 TK1 FEN1 CENPM POLA2 FAH ESPL1 POLR2H TALDO1 PCK2 TUBA1B PGAM1 MIS18A POLQ CHEK1 SAC3D1 MCM7 LMNB2 ACOT7 NEIL3 RAD54L FIBP UMPS SAP30 PPCDC KIF2C PTTG1 SHCBP1 RAD51 CDC20 KIF20A NME1 CPPED1 TUBA1C SMCO4 FOXM1 DPP3 DTYMK GPN3 CCNB1 TRAIP GSTO1 UBFD1 CORO1C CCDC51 CDC6 MKI67 OIP5 NCAPH BIRC5 TUBG1 CDCA8 TMEM106C CDC25A BUB1 MCM10 RFC4 TUBB6 IMMT KIF11 BDH1 GPR19 DCTPP1 SPAG5 GINS2 ZWINT FANCI STMN1 TYMS IFI30 SPATA5L1 CCNB2 CEP55 PBK KIF15 GMNN CKAP5 DNAJB6 RAD51AP1 RRM2 DUT UBE2C SRM TTF2 VDR CENPA DTL TTI2 FBXO5 NCAPG STIL BUB1B ASPM RAD51D PFAS IL2RA HMMR SLC43A3 DSN1 TOP2A TXN CENPE NUSAP1 DLGAP5 BATF AURKA SRSF1 up
## GSE9988_ANTI_TREM1_AND_LPS_VS_VEHICLE_TREATED_MONOCYTES_DN 0.0039370 0.0070876 0.5937004 3.116047 0 189 SRSF9 TWF2 HCK PPP1R9B RAP2B OAZ1 GABARAP PSAP SLC16A3 ABI3 RGS19 TMED9 MAP7D1 PCBP1 APOBR CSK MRFAP1 KCTD2 PRR13 SUN2 CD14 DOK2 PLIN3 RHOG SETD1B CSF1R PPP1CA STK11 ATF5 PRELID1 COTL1 TNFAIP8L2 NELFA NCKAP5L NLRP12 LGALS1 EMP3 IRF5 BUD13 CORO1A ARPC1B TNFRSF1A IL27RA ARHGAP30 CDC34 ANKRD13D PLEKHO2 MYO1F NFIC ENO1 ARHGAP22 FRAT1 GNAI2 PHF23 ATXN7L3 GAL3ST4 GRN SASH3 ATG9A RPS6KA1 TFEB TGFBI KLHDC3 PIK3R5 CALHM2 WRAP73 MLXIP CCR2 YWHAG CENPB MAST3 CTDSP1 MOB3A MAP3K3 BCL9L PIK3CD FAM78A SDHA SLX4 NAGS PLXNB2 IKBKE GNB2 IFI30 IL10RA USP19 PATZ1 KDM4A TNFAIP8L1 LAPTM5 WBP1L CMTM3 TARS2 RUNX3 THAP11 up
## GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_12H_UP 0.0038610 0.0070876 0.5982045 3.112671 0 174 ROM1 MCM5 NUPR1 HMGB2 CDC45 MRPS11 TK1 VCP INCENP TACC3 POLE SPC24 PLK1 LIG1 LSP1 PYCARD PRC1 TXNRD1 CENPN UHRF1 NCAPD2 CHEK1 MCM7 AUNIP LMNB1 NEIL3 RAD54L MCM3 MTCH1 ITGAM CPOX SHCBP1 RAD51 KIF4A ASF1B CHAF1B MCM4 FKBP2 BSCL2 EIF3C CPT1A RACGAP1 CENPW CENPP GNAI2 TSPAN32 RRM1 CCNA2 AURKB RINL ANAPC5 CDC6 MKI67 TPX2 NCAPH BIRC5 CDCA8 CLSPN CDC25C HNRNPUL1 EME1 BUB1 ZBTB32 TOPBP1 ITGAX ARF6 KIF11 SPAG5 STMN1 PRIM1 MT2A PRR11 CCNE1 CENPH NHLH1 CCNB2 CTSD ESCO2 CEP55 PBK BRCA1 KIF15 KIF23 RAD51AP1 RRM2 DUT KDM4A FBXO5 NCAPG BUB1B ASPM GINS1 HMMR TOP2A CENPE WDR76 DLGAP5 SMC2 AURKA up
## GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_UP 0.0039370 0.0070876 0.5923735 3.100048 0 183 RBBP8 MCM2 CDC45 MRPL11 MRPS11 EMC9 TK1 FEN1 PPIL2 CENPM CDT1 FANCG GALK1 SLBP LIG1 SHMT2 ACTR1B TOX4 PRC1 CENPN MRPS12 MCM7 KIF22 LMNB1 RAC2 PSRC1 FIBP PPCDC KIF2C NCF4 PTTG1 CORO1A NCAPG2 DONSON RAD51 UBE2S KIF4A MCM4 DDX49 CDC20 DAZAP1 RNASEH2A KNTC1 HNRNPAB DPP3 CCR3 CCNB1 CCNA2 UBFD1 AURKB CCDC51 ATAD2 TPX2 RPL39L KLHL25 BIRC5 SNF8 CDCA8 TMEM106C IDH2 BUB1 RFC4 KIF11 RCC1 GATA3 GPR19 SPAG5 MYBL2 ZWINT FANCI BLM TYMS CCNB2 EZH2 CD79B CEP55 KIF15 INHBE GMNN RRM2 CASP9 DUT TNFSF10 UBE2C TUBB4B IL2RB CENPA DTL IGHM CSTF2 PLK4 ASL GINS1 NDUFA7 IL2RA TRIP13 CENPE NUSAP1 IL32 WDR76 DLGAP5 HJURP PPP1R16B AURKA PXMP2 MELK up
## GSE26156_DOUBLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_DN 0.0039370 0.0070876 0.5898488 3.095832 0 189 MRPL28 AP2S1 UNG MYL6B FEN1 MRPL23 VCP BCAT2 TOMM40 NPM3 ATOX1 FADD TMED9 ACTN4 ECI1 MRPL40 CHAF1A PLK1 NEFH HMGN2 RUVBL2 SHMT2 PCK2 TNIP1 TUBA1B CHEK1 CD63 ACOT7 PARP1 GRHPR MCM3 POLR2G LAG3 PCCB ETHE1 UBE2S SLC1A5 PSMD8 FARSA MFSD10 EBNA1BP2 AK4 ENO1 TCEAL4 PSMB5 NME1 MTHFD2 HNRNPAB CCNB1 TRIP10 HNRNPA0 MATK FSCN1 CDC6 TPX2 PRDX1 TUBG1 TMEM106C IDH2 RRP7A CDC25C GZMB HAX1 HMGN4 TIAM1 PHGDH LDHA RFC4 IMMT KIF11 COX6A1 BDH1 SPAG5 CCT5 MYBL2 NKG7 PRIM1 CCNE1 TYMS CCNB2 NIPSNAP1 SOCS1 EZH2 SIT1 PMVK GBP1 CKAP5 UBE2C AHCY GTF2E2 SRM RPA2 TTF2 HDGF BUB1B STAMBP NDUFA7 LCP2 AIFM1 HMMR SRD5A1 TXN CENPE DBI DLGAP5 AURKA HSP90AB1 NHP2 MTHFD1 EIF4A1 DMC1 CENPF CKS2 PSMB2 up
## GSE22103_UNSTIM_VS_GMCSF_AND_IFNG_STIM_NEUTROPHIL_DN 0.0039370 0.0070876 0.5893291 3.094613 0 185 GPI UNG C12orf10 PPARGC1B NDUFS7 KCNE3 MCM5 CCDC106 TMEM160 FAM98C DCPS GSDMD THOP1 SH3BP1 CCDC88B MAN2C1 MRPL52 PYCR2 NEFH TCIRG1 DOK2 LZTS2 RUVBL2 PYCARD FAU UQCR11 TIMM13 SCAND1 PNKP PRELID1 RAD54L FES NDUFB10 JMJD6 CDCA2 PTTG1 PSMB10 HSPB1 EHD4 MCM4 MYO1F TYROBP PLD4 TMEM223 KNTC1 CKAP2L PPM1J COPE STC2 RINL TTC38 LHPP SLC6A13 DCAF4 RND2 AP1S1 HOXA2 CLSPN NAGA MPG PHGDH SPPL2B WDR83OS CLEC11A GUCA1A SIGIRR DCTPP1 RPL35 FANCA AGRP SIRT3 DNAJC4 GALE RAPGEF3 CCNB2 MAP4K1 PARD6G ESCO2 INPP5B RPL36 UBE2C ITGAL RASGRP2 SAPCD2 IGHM CMTR1 ENOPH1 LRWD1 KLHL17 FAM168A AMZ1 PAM16 CENPE ACAT2 PRMT7 up
## GSE42021_CD24LO_TREG_VS_CD24LO_TCONV_THYMUS_DN 0.0039370 0.0070876 0.5851611 3.072726 0 185 RBM42 NPEPL1 ESRRA EIF3K MBD3 TIMM8B PRKCSH ULK1 FKBP8 NDST2 BCAT2 PSME1 TBC1D22A CLTA NDUFS3 SCARB1 DCTN3 UBALD2 CSK XRCC1 MEA1 ANAPC11 UQCRC1 TALDO1 MFSD5 MXD4 PTPN18 URM1 MAF1 ERP29 MRPS12 AURKAIP1 SMARCB1 MAP4K2 CAPNS1 PPFIA4 PNKP PNPLA2 TYMP FES ARHGDIA GTF2F1 TMEM259 PDHA1 COLGALT1 JMJD8 SAP30 CDC37 ETHE1 ING4 CDK5 MAN2B1 CLPP STOML2 PSMD3 TYSND1 ENO1 STRN4 MRPL20 RNASEH2A PRPF6 SEC61A1 PSMB6 GRN BAK1 SNRPD2 ZFYVE19 CSNK1G2 GNAS MAPK3 RPP25L RPL19 MAST3 CIAO1 NUBP1 LYPLA2 CYBA NUP85 GOLGA3 LMAN2 RASD1 RPS16 C1QB RPUSD4 MRPL34 DFFA RBCK1 U2AF1L4 SEMA6B RPL3 TMEM179B GBA2 DUS1L MKNK2 ECHS1 SNX12 TNFSF10 GUK1 VAMP8 TFIP11 up
## GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_DN 0.0040161 0.0070876 0.5849484 3.060916 0 188 MRPL28 GPI PFKM MCM2 TWF2 MCM5 CDC45 PKM NUDT1 DOK1 FEN1 MRPL23 ALDOA VCP TOMM40 FAH THOP1 PTMS ACTN4 ESPL1 NEFH HMGN2 RUVBL2 SHMT2 PCK2 COMT TUBA1B NCAPD2 MRPS12 AHCYL1 CD63 GPX1 ACOT7 RAD54L MCM3 UMPS SAP30 LGALS1 PTTG1 EXOSC2 LSM4 COX8A UBE2S GZMH SLC1A5 MCM4 EBNA1BP2 CDC20 ENO1 NME1 CYFIP1 CSF2 PSMB3 CCNB1 CCNA2 TRIP10 AURKB CCL20 CDC6 MKI67 TPX2 PRDX1 TUBG1 TMEM106C CDC25C GZMB TIAM1 PHGDH LDHA KIF11 COX6A1 BDH1 CCT5 MYBL2 FANCI DFFA TYMS CCNB2 EZH2 ATF1 PMVK BRCA1 GSTP1 AP4M1 RAD51AP1 RRM2 STX11 UBE2C AHCY SRM TNFRSF9 STAMBP GCNT2 GINS1 ABCB6 POLD2 CST7 DBI DLGAP5 CDK4 SMC2 AURKA up
## GSE36826_WT_VS_IL1R_KO_SKIN_STAPH_AUREUS_INF_UP 0.0039370 0.0070876 0.5820839 3.056568 0 185 GPI MCM2 MCM5 RANBP1 CDC45 EMC6 TK1 PSME2 HK1 COX5B CLTA POTEKP SLC22A18AS DNAJC9 FCN1 TCIRG1 PSMC4 PGAM1 MRPS12 SH3BGRL3 PSMA7 ACOT7 PARP1 GTF2F1 DEF6 RAC2 GCLM PCCB ATP2A2 NCAPG2 DONSON KIF4A ROGDI PSMD8 PEX10 RACGAP1 HK2 POP5 ALOX5AP KIF20A ARPC5L PROCR RRM1 DPP3 PSMB6 CCNB1 DDX39A IFI35 RAN PDIA5 BAK1 SPR BST1 PSTPIP1 TTC1 COX17 COX5A POLR2L LASP1 APEH P4HB MKI67 TPX2 TUBG1 RRP7A AATF PPBP CDC25A SEC13 P4HA2 RFC4 ACLY COX6A1 EIF4G3 ZWINT FANCI PRIM1 GALE ACTR1A CCNB2 FASN PSMB1 BLVRA ARF3 CEP55 COPS7A COX6C PSMB7 UBE2C FBXO5 NCAPG IPO4 TBCD MAPKAPK3 PSMC1 NUSAP1 ILF2 up
## GSE9006_TYPE_1_DIABETES_AT_DX_VS_1MONTH_POST_DX_PBMC_UP 0.0040161 0.0070876 0.5833423 3.052511 0 188 GPI SRSF9 RBM42 AMDHD2 PPIF HMGB2 RPN1 ABCF3 PSMC3 ANP32A TMEM160 DDIT4 ALDOA COPG1 TSPAN14 BANF1 BRMS1 POTEKP RAB1B NDUFV1 CDT1 MRPL12 ARPC4 HNRNPA1 AMBRA1 UQCRC1 SART1 TBL3 MFN2 PFN1 KLHL2 SVIL CHFR NCAPH2 PPP4C ECSIT AAMP TMEM259 KIF2C CDC37 ATP2A2 UBE2S KIF4A SH3GLB2 CDK9 EHD4 FARSA FDXR FZR1 WDR18 GSR SAFB MSL2 XAB2 DNAJC17 PRPF6 ARAF MAFB JUNB SAFB2 CORO1C PHF21A GLUD2 P4HB BSG TPD52L2 GSN CYBA PIM1 ODF2 NCL ARF6 DAZAP2 CDCA4 PTBP1 THOC6 CTSD EGLN1 SOCS1 PDIA4 CYP51A1 STX11 SNRNP40 AHCY AGPAT3 ICAM3 GPR132 GLUL ZFP36L1 TMCO3 HSP90B1 RRP12 HBEGF HSPA9 PSPN CDK2 up
## GSE9988_ANTI_TREM1_VS_ANTI_TREM1_AND_LPS_MONOCYTE_UP 0.0040161 0.0070876 0.5773804 3.043533 0 194 PPIF TWF2 RNF168 MYL6 MBD4 RAP2B SLC8B1 DOK1 ALDOA ZYX SERTAD3 GABARAP CLTA FRAT2 ARF5 RGS19 CNBP RNF7 LRRC25 MAP7D1 PCBP1 APOBR MRFAP1 PRR13 TSR2 NELFB DOK2 BCKDK PPP1CA CD2BP2 OGFR PSMA7 PPP4C S100A2 PRELID1 ACTB ARRB2 JMJD8 FTH1 SLC37A2 MNT ZNF511 MAP1S CYTH4 SERTAD1 ORAI3 TNFRSF1A PI4K2A FUOM PHF13 ARHGAP30 CKAP4 COASY CXXC5 PLEKHO2 BLOC1S3 NFIC ARL11 ENO1 LINC01010 FRAT1 ARPC5L FKBP15 PHF23 ATXN7L3 PRMT6 TLE3 HNRNPA0 LASP1 CD300LB ST6GALNAC6 CENPBD1 NRBP1 RREB1 NDUFB2 YWHAG MCOLN1 RARA CTDSP1 CCDC97 CYB561D1 GGA2 GNB2 ARID5A IFI30 HOMER3 SH3BP5 MKRN1 KLHL26 NTAN1 VRK3 TMEM203 RNF41 ZNF503 SNX12 AP1M1 KDM4A HAVCR2 CMTM3 PSMD7 MED8 CDV3 up
## GSE24574_BCL6_LOW_TFH_VS_TCONV_CD4_TCELL_DN 0.0039370 0.0070876 0.5802183 3.036436 0 183 MRPL28 AP2S1 UNG MCM2 PKM VCP HIRIP3 GAPDH BCAT2 TOMM40 ST14 FAH FADD THOP1 TMED9 PSMD13 ESPL1 ECI1 ORC1 CHAF1A PLK1 NEFH HMGN2 SHMT2 COMT NCAPD2 MRPS12 AHCYL1 GPX1 PARP1 RAD54L MCM3 TXN2 GCLM UMPS UBE2M TXLNA LGALS1 CPOX SNRPA CORO1A COX8A PCBD1 SLC1A5 MCM4 FKBP2 EBNA1BP2 ENO1 MTHFD2 TRAIP EIF3I AURKB HTATIP2 FSCN1 PRDX1 TUBG1 IDH2 TRAF1 HAX1 HMGN4 TIAM1 PHGDH LDHA RFC4 TM7SF2 IMMT COX6A1 BDH1 MYBL2 ZWINT FANCI DFFA PRIM1 TEAD4 BLM GALE TYMS NIPSNAP1 EZH2 SIT1 ECHS1 PMVK GSTP1 RAD51AP1 ACTA1 TNFSF10 STX11 GTF2E2 SRM RPA2 HMGCL TTF2 TNFRSF9 BUB1B PLK4 GINS1 PFAS CDK2 AIFM1 HMMR TOP2A TXN DBI CDK4 AURKA MELK XCL2 TTK MTHFD1 GOT1 EIF4A1 up
## GSE42021_CD24HI_TREG_VS_CD24HI_TCONV_THYMUS_UP 0.0039370 0.0070876 0.5798610 3.034566 0 183 AKT2 RBM42 PTOV1 HRAS UBXN1 CDC45 SART3 ESRRA EIF3K PRKCSH ISYNA1 ALDOA FKBP8 NDST2 ETFB CLTA NDUFS3 ECH1 EIF2B5 SSNA1 ANAPC11 UQCRC1 MXD4 MAF1 HCN2 ERP29 MRPS12 AURKAIP1 CAPNS1 PPFIA4 PNKP PNPLA2 LSR TYMP FES ACTB ARHGDIA TMEM259 PDHA1 COLGALT1 ARX CEP250 CDC37 ING4 CHD8 MAN2B1 PPP1R14B CLPP STOML2 NFIC LEMD2 ENO1 CEP89 RNASEH2A LRP10 XAB2 PSMB6 SNAPC2 GRN SCAMP2 BAK1 ASXL1 COPE FBXW4 ZFYVE19 EIF3G CSNK1G2 GNAS MAPK3 CCR2 RPP25L RPL19 MAST3 CIAO1 NUBP1 CYBA MRPL4 LMAN2 MCM10 C1QB WBP11 NR1H3 DFFA LRP1 IFI30 TMEM179B RPS6KB2 DUS1L MKNK2 ECHS1 HOXC5 XRCC2 PCSK7 FOXO3 VAMP8 TFIP11 DDX27 FABP3 SLC27A1 CD52 TCF25 up
## GSE22886_NAIVE_BCELL_VS_MONOCYTE_DN 0.0040486 0.0070876 0.5809843 3.034227 0 187 S100A8 TWF2 PKM ZMIZ1 HCK TIMM8B S100A9 STXBP2 VASP ALDOA PSAP RNH1 SLC16A3 GAPDH CLTA CEBPB EFHD2 CHMP2A SULT1A1 CD300A TMED1 MAP7D1 NUP62 CAPG PXN CD14 UQCRC1 TALDO1 MOGS BID EIF4G1 RHOG NOD2 GLRX SVIL AKR1A1 GPX1 S100A4 ARRB2 MGAT1 TNFRSF1B ITGAM LGALS1 LRPAP1 PNPLA6 PGD TNFRSF1A CKAP4 NAGK MYO1F RTN4 TYROBP IGF2R CSTA MAFB GRN G6PD RPS6KA1 RXRA MTMR14 METTL9 NCF2 ABR TNFSF13 IMMT ATP6V0C NDUFS6 CTSB PLXNB2 SLC7A7 IRAK3 IFI30 CSF2RB SLC11A1 CTSD THEMIS2 FTL PISD IL10RA RBM47 ITGAL FCER1G HPCAL1 UBR4 MAPKAPK3 SEMA4D SRGN CHST15 TRIM8 RNF130 GYG1 QPCT TMEM11 SERPINB6 ATG3 FCGR2A CLEC7A TPP1 TNFAIP2 up
fgsea_plot(fgsea_res$res_msg, pathways_title='All signatures', condition_name= cond_nm)##
##
## pathway pval padj ES NES nMoreExtreme size leadingEdge state
## ----------------------------------------------------------------- ---------- ---------- ---------- --------- ------------- ----- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ------
## GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0034965 0.0160999 0.7207604 3.770151 0 187 SRSF9 RBM42 HNRNPM TSSC4 HRAS PAF1 PIN1 ABCF3 NFKBIB DGKZ IRF3 THAP7 HMG20B CFL1 TAF10 COPG1 TSPAN14 BANF1 SSRP1 CCS ARF5 BRMS1 TSR3 RAB1B GPS2 U2AF2 TMED9 TACC3 MRPL12 HTRA2 ARPC4 SPINT2 AIP GADD45GIP1 AMBRA1 ADRM1 NELFB SART1 DRAP1 CCDC85B C9orf16 TBL3 PTPRCAP PFN1 ERP29 PRPF19 POLR2E STARD3 AURKAIP1 SAC3D1 PTMA SIPA1 NONO VPS51 AAMP TMEM259 PDCD4-AS1 UBE2M SLC25A22 QTRT1 NADSYN1 LIMD2 NDUFC1 CDC37 PSMB10 WDR74 CORO1A E4F1 UBE2S ZBTB17 SH3GLB2 GZMM CDK9 TRIM28 MFSD10 SDF2L1 SLC2A4RG WDR18 DAZAP1 ABHD17A SAFB TAF1C SNRPF XAB2 DNAJC17 NOC2L PEX5 PDAP1 VPS9D1 SAFB2 SMARCD2 UBN1 FBXO41 TNFRSF14 EDF1 ZNF512B SREBF1 APBA3 SNRNP70 SNF8 GSN SF3A2 CLPTM1 RALY DCAF15 SIGIRR ANAPC2 GCDH RPLP2 RALGDS CDCA4 PTBP1 THOC6 PFDN2 CD7 STK25 EEF1D FUS PDIA4 EXOC7 RPL36 RRS1 PPP6R2 CD81 RASGRP2 ATP13A1 up
## GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP 0.0034722 0.0160999 0.6799831 3.534820 0 181 SRSF9 HNRNPM C12orf10 HRAS RPN1 DGKZ HMG20B R3HCC1 CFL1 TAF10 CORO1B COPG1 TSPAN14 SSRP1 TSR3 GPS2 CALM3 U2AF2 TMED9 MRPL12 PCBP1 ARPC4 PKN1 ADRM1 DEAF1 DOK2 SART1 DRAP1 CCDC85B C9orf16 FBXL15 PTPRCAP PFN1 NDUFS8 ERP29 POLR2E STARD3 AURKAIP1 SAC3D1 FCHO1 COTL1 ECSIT MYH9 NONO RNF126 GTF2F1 VPS51 RNF19B NADSYN1 LIMD2 NDUFC1 CDC37 PSMB10 GID8 UBE2S SH3GLB2 GZMM TGFB1 MFNG ELF4 PPP1R14B ZNF580 MFSD10 CHCHD3 DDX49 CBX4 LRRC47 WDR18 DAZAP1 MINK1 SAFB SNRPF XAB2 MAP2K2 PDAP1 ILVBL SAFB2 SMARCD2 RDH14 CAPN15 COX5A FBXO41 BECN1 TNFRSF14 EDF1 ZNF512B SNF8 APRT GSN HNRNPUL1 SF3A2 MSN BCL7C RALY RPLP2 CDCA4 EIF3F WDR45 RBCK1 PTBP1 YBX1 THOC6 PFDN2 STK25 HMOX1 PDIA4 PABPN1 AHCY CD81 RASGRP2 PMS2P2 MVP up
## GSE9601_UNTREATED_VS_PI3K_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_UP 0.0032895 0.0160999 0.6870659 3.516165 0 162 FRMD8 SHKBP1 DDX54 TSSC4 ARL6IP4 IRF3 THAP7 PPP1R9B MBD3 NOSIP CSF1 RNASEH2C FKBP8 SSRP1 RAB1B OSBPL5 SCPEP1 DNMT1 CAPG NFKBIE MEA1 MED15 HMGN2 SF3B2 PSMC4 SIRT7 DDX41 PYCARD TNIP1 SDF4 PTPRS NDUFS8 MIIP MAP4K2 SIPA1 LMNB1 CXXC1 MYH9 ARHGDIA GTF2F1 TLN1 MCM3 TICRR CCDC12 TUBGCP2 KIF2C PSMB10 CORO1A EHD4 RCC2 MYO1F PREX1 SERF2 CENPW IGF2R MAP2K2 NCAPD3 PSMB4 TMCO4 SASH3 TFEB SRRT RGS14 WBP1 ANKRD11 POLR2L BSG TPX2 SF3A3 CSNK1G2 NDUFS5 BIRC5 B4GALT7 CDCA8 FMNL1 TRAF1 CYBA CCDC97 IRF9 PRRC2B RPL38 RAB4B MYO18A PIM1 RPL41 E2F7 FLII BDH1 RELB HNRNPL CTBP1 RBCK1 GIMAP7 OS9 YBX1 MAD1L1 IRF1 BRCA1 EXOC7 RPL18 up
## GSE45837_WT_VS_GFI1_KO_PDC_DN 0.0034722 0.0160999 0.6681285 3.470211 0 180 ZNF428 NDUFS7 TWF2 MCM5 PIN1 ARL6IP4 MRPS11 PSMC5 EIF3K MPI R3HCC1 NUDT1 MRPL23 MZT2B ETFB SNRNP25 MRPS34 NPM3 ARF5 PSMD13 GANAB SUN2 PFKP ECI1 MZT2A MRPL40 HMGN2 PRMT1 DRAP1 SHMT2 CCT7 UQCR11 ERP29 POLR2F COX6B1 DNPH1 CD2BP2 GMFG BST2 UBE2Z ECSIT GRHPR FASTK RFXANK AAMP SOD1 POLR2I PLEKHJ1 ENSA UBL5 ETHE1 ARPC1B COX8A CAPZB HSPB1 PSMD8 NUMA1 MRPS16 CTDNEP1 DDX49 EBNA1BP2 STOML2 PSMD9 SNRPF PDCD5 NME1 PSMB6 PSMD4 RAN LSM7 UQCRH EIF3I SNRNP35 ANXA11 SNRPD2 COX5A BANP SPECC1L EDF1 PARL TOR3A COPS6 MPG PIM1 LMAN2 CLASRP EPS8L2 CLPTM1 DFFB NDUFS6 SAE1 MPDU1 SET RALGDS EIF3F RBCK1 UCKL1 RANGRF NIPSNAP1 VOPP1 NDUFA2 FUS DYNLRB1 TOE1 TRAPPC2L AHCY AUP1 RASGRP2 TRADD XRCC6 KCNN4 DECR2 NDUFA7 EEF2 DDT OCEL1 TCF20 DBI CDC42SE1 CBX7 IGBP1 up
## ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 0.0032895 0.0160999 0.7024960 3.446104 0 130 MCM2 HMGB2 CDKN2A TK1 EIF4EBP1 FEN1 TMSB10 CENPM POLA2 TACC3 ESPL1 PLK1 BID PRC1 HMGA1 POLQ CHEK1 SAC3D1 LMNB1 GINS4 KIF2C PTTG1 LSM4 SHCBP1 UBE2S KIF4A ASF1B CHAF1B MCM4 RACGAP1 CDC20 GTSE1 KIF20A CCNF FOXM1 DPP3 DTYMK CCNB1 CCNA2 AURKB ATAD2 KIF18B CDC6 MKI67 LRP8 TPX2 OIP5 NCAPH BIRC5 CDCA8 BUB1 MCM10 E2F1 KIF11 NEK2 SPAG5 MYBL2 ZWINT FANCI TYMS PAQR4 CCNB2 EZH2 MAPK13 CEP55 PBK BRCA1 KIF15 KIF23 GMNN SMC4 RAD51AP1 RRM2 UBE2C CENPA DTL FBXO5 DNMT3B NCAPG STIL BUB1B ASPM GINS1 HMMR TRIP13 TOP2A CENPE NUSAP1 DLGAP5 HJURP SMC2 PLEK2 AURKA MELK TTK KIF20B PAFAH1B3 TMPO CENPF ECT2 CKS2 KIF14 up
## SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 0.0032680 0.0160999 0.6828265 3.377568 0 138 HMCES TIMM10 MCM2 CDC45 TIMELESS NUDT1 FEN1 PKMYT1 TACC3 MRPL12 ESPL1 DNAJC9 GMPS PLK1 SHMT2 PRC1 TXNRD1 TUBA1B CENPN MIS18A POLQ CHEK1 PSMA7 LMNB1 JMJD6 MCM3 MCM6 KIF2C PTTG1 NCAPG2 DONSON RAD51 UBE2S KIF4A ORMDL2 MCM4 RACGAP1 CDC20 GTSE1 DSCC1 SNRPF RNASEH2A KIF20A NME1 TUBA1C FOXM1 TROAP CCNB1 DDX39A CCNA2 AURKB KIF18B MKI67 TPX2 OIP5 NUP93 NCAPH BIRC5 CDCA8 CDC25A BUB1 STIP1 MCM10 RFC4 E2F1 KIF11 NEK2 SPAG5 CCT5 MYBL2 ZWINT STMN1 BLM CCNB2 EZH2 CEP55 KIF15 RRM2 UBE2C CENPA FBXO5 QPRT NCAPG STIL BUB1B ASPM GINS1 CDK2 HMMR TRIP13 PARPBP DSN1 TOP2A TXN CENPE NUSAP1 DLGAP5 HJURP SLC7A5 AURKA MELK TTK TMPO CENPF ECT2 CKS2 KIF14 up
## GSE16385_MONOCYTE_VS_12H_IL4_TREATED_MACROPHAGE_DN 0.0034843 0.0160999 0.6446246 3.354637 0 183 JOSD2 ABCB9 HMG20B RAB35 RPS6KA4 NPM3 ABI3 ZBTB48 GPS2 CHD4 XRCC1 UTP3 MAP3K11 PHRF1 ZFAND2B SIRT2 PACSIN1 NELFB USP11 STX4 CLCN7 PPP1R12C AKT1S1 ERP29 POLRMT DDB1 ZNF384 MIIP MAP4K2 FCHO1 RNF31 LMNB1 COTL1 DENND4B TRIM11 FASTK TLN1 TMEM259 WHAMM TATDN2 STX5 SH2B1 MLLT6 RNF19B ABHD8 HDAC7 NCLN CORO1A ALDH2 ATXN2L ANKRD54 IL27RA TSC22D4 CAPZB TESK1 AP3D1 PPP1R37 STRN4 LIPE LRP10 ZNF777 PIK3R4 TBC1D9B TRABD LMF2 ARID1A MAPK8IP3 GLYR1 GUCD1 FAM20A IFFO1 PIK3R5 WBP1 LASP1 DCLK2 ZNF653 CIZ1 MBP PQBP1 SNRNP70 LMAN2L CCDC97 MOB3A HCLS1 UBA7 LRSAM1 CHRNB1 TUFM CYTH1 ACPP GNB2 RAPGEF3 ACAP1 UCKL1 RPS6KB2 GALT SNAPC4 MND1 FAM193B TOMM34 EGLN2 ABCA7 STRIP1 AUP1 up
## GSE369_PRE_VS_POST_IL6_INJECTION_SOCS3_KO_LIVER_DN 0.0034965 0.0160999 0.6360914 3.327265 0 187 ZNF428 LZTR1 BLVRB MCM5 RBP1 TADA3 DGKZ RHBDD3 R3HCC1 PRKCSH STXBP2 ZYX ANAPC15 PPIL2 GABARAP SUPT5H EPHB2 ZBTB48 STAB1 RGS19 NUCB1 NAGPA TSR3 UBTF BTBD2 EIF2B5 POLE MLF2 MAN2C1 MAP3K11 SH3GL1 MEA1 SART1 RHOG PLD3 ARAP1 CAMK1 ERP29 CSF1R VAV1 DDB1 ZFPL1 PIP5K1C DENND4B ARRB2 CACTIN TMEM259 TBXAS1 TXN2 PLCB3 NCF4 KCNAB2 TBC1D2B RAB11B MEGF8 TRIM28 MAN2B1 RANGAP1 AGRN MYO1F MAZ MYO9B RTN1 RNF40 LRP10 MAP2K2 TBC1D9B PRPF6 CD4 GNPDA1 LTBR FCGBP GRN WBP2 SLC4A2 IFFO1 GDF11 BSG SGSH MAPK3 HADHA SUPT6H ERAL1 IDH2 IL10RB RAB4B SNN CLPTM1 CLEC11A ATP6V0C ARFIP2 GCDH ARSA TSPAN4 OS9 FASN PFKFB3 GSTP1 HIRA GBF1 GDI1 PCSK7 FCGRT FOLR2 WBP1L CMTR1 TRADD up
## GSE22589_HEALTHY_VS_SIV_INFECTED_DC_UP 0.0034722 0.0160999 0.6389657 3.304054 0 179 KCNE3 RILPL1 TIMELESS TMEM160 DDX23 ABI3 DOHH DHRS13 GPS2 MRPL12 POLD1 CLK3 BTBD2 PTK2B CCDC88B GADD45GIP1 UBAC1 DAPK3 SDHAF1 GRK6 TCIRG1 FERMT3 TELO2 PTPN18 STUB1 PARK7 TUBA1B TIMM13 PICK1 SLC2A1 SLC7A1 LMNB2 SIPA1 NCAPH2 SNORD104 LAMTOR1 FES NDUFB10 JMJD6 ARRB2 VPS51 PSRC1 POLR2I POLR2J ADM CYTH4 MED12 MRPL17 ANKRD54 HSPB1 HAGHL MEGF8 ANKRD13D STAT6 CHCHD5 NFIC HK2 INF2 FKBP15 NOL12 CDK5RAP3 NR1H2 JUN LTBR ZFHX3 FGD2 RPL13 DNAJB1 NLRP3 PSTPIP1 RGS14 MATK SLC7A6OS NDUFS5 DBNL LLGL1 SLC6A13 SREBF1 ZNF593 AGAP3 CIITA MPG PPP1R16A TUBB6 PARP2 MLLT1 DVL1 SIGIRR EIF4G3 ELAC2 DNAJC4 TRIP6 MT1E DDX11 ATF4 VRK3 SLC12A9 IRF1 IL4R RPL36 MAPKAPK5 CARD11 SAPCD2 XRCC6 LRWD1 up
## MORF_NME2 0.0031847 0.0160999 0.6588520 3.285361 0 141 UBC AP2M1 MYL6 TBCB NDUFA1 OAZ1 COX5B CFL1 MRPL23 ALDOA BANF1 ARF5 TSR3 GANAB POLR2H SSNA1 HMGN2 URM1 C9orf16 TUBA1B FAU CCT7 PFN1 COX6B1 RPLP0 SPAG7 CYC1 ACTB COX4I1 COX8A OTUB1 PSMD8 STOML2 UBB ENO1 HUWE1 NME1 RPS12 PSMB4 PDAP1 RAN DNPEP CALR RPL13 UBE2I GNAS RPL19 COPS6 LYPLA2 RPL38 LDHA RPS16 RPL27A RALY COX6A1 RPL35 SNRPB RPLP2 PSMB1 UBA1 NDUFA2 EEF1D RPL12 TMEM147 RPL18 RPS24 HDGF ATP6V1F RPS3 EEF2 RPS6 COX7C RPL13A PSMC1 NPM1 RPL18A RPS14 RPL11 RPL36AL NACA PPIA CANX PUF60 HSP90AB1 EIF4A1 PABPC1 RPL23A RPS20 SUMO3 HSPD1 RPL8 SRP14 RPS27A up
## GSE14415_NATURAL_TREG_VS_TCONV_DN 0.0033113 0.0160999 0.6340164 3.278960 0 173 MCM2 ROM1 MCM5 HMGB2 CDC45 TK1 CENPM TACC3 PTMS CHTF18 SCAF1 EHBP1L1 SPC24 PLK1 LIG1 LSP1 PYCARD PRC1 CENPN UHRF1 NCAPD2 CHEK1 MCM7 AUNIP LMNB1 NEIL3 RAD54L ACTB MCM3 MTCH1 ITGAM ATP2A2 RAD51 KIF4A ASF1B CHAF1B NCKIPSD MCM4 FKBP2 CTSC DISP2 ANP32B GSR CENPP GNAI2 RRM1 CCNA2 SLC41A3 CKAP2L ASXL1 TPX2 RAB39A NCAPH BIRC5 CDCA8 CLSPN CDC25C HNRNPUL1 GZMB BUB1 ZBTB32 CNIH2 TOPBP1 SPN ABR MSN ITGAX ARF6 HCLS1 KIF11 SPAG5 ABRACL MRPL34 STMN1 HOXB2 BLM PRR11 CENPH CCNB2 AGFG2 CTSD ESCO2 CEP55 PBK BRCA1 KIF15 FAM117A KIF23 RRM2 DUT KDM4A FBXO5 NCAPG BUB1B ASPM GINS1 IQGAP3 CKM HMMR SLC43A3 PROSER2 TOP2A CENPE PDLIM4 DLGAP5 TEAD3 SMC2 AURKA GPR55 up
## GSE9988_LPS_VS_VEHICLE_TREATED_MONOCYTE_DN 0.0035587 0.0160999 0.6265125 3.274603 0 191 UNC45A ZNF740 TWF2 DGKZ PPP1R9B RAP2B SERTAD3 GABARAP PSAP FRAT2 RGS19 ZNF467 TACC3 MAP7D1 PCBP1 APOBR CSK PFKFB4 UBAC1 PRR13 SH3GL1 LYL1 DOK2 PLIN3 RHOG ARAP1 SETD1B CSF1R PPP1CA STK11 ATF5 PIP5K1C PRELID1 COTL1 PGP TTC7A TNFAIP8L2 NELFA MTCH1 NCKAP5L TCHP ZNF688 ZNF511 NLRP12 LGALS1 CORO1A ORAI3 ARPC1B TNFRSF1A IL27RA TRAPPC12 ARHGAP30 CDC34 FAM214B ANKRD13D VMO1 PLEKHO2 MYO1F TYROBP NFIC ARHGAP22 FRAT1 NUDT16L1 PHF23 ATXN7L3 GRN SASH3 ATG9A RPS6KA1 TFEB TGFBI KLHDC3 IFFO1 CALHM2 MLXIP RGS12 CCR2 CENPB MAST3 RARA CTDSP1 MPG ARHGAP1 TMEM101 MAP3K3 GLTP PIK3CD FAM78A SDHA NAGS SPIDR PLXNB2 IFI30 NCOR2 USP19 GSTP1 APBB1IP BRD3 LAPTM5 WBP1L CMTM3 GLUL RUNX3 THAP11 up
## MORF_AP2M1 0.0036101 0.0160999 0.6189795 3.264593 0 203 GPI SRSF9 AP2S1 UBC COMMD4 AP2M1 PKM TADA3 MBD4 TBCB NDUFA1 COX5B CFL1 MRPL23 GABARAP VCP CLTA BANF1 ARF5 ATOX1 CNBP TSR3 CAPN1 TMED9 GANAB ACTN4 PPP2R1A POLR2H SSNA1 MAP3K11 PRMT1 SF3B2 STX4 URM1 C9orf16 TUBA1B FAU CCT7 PGAM1 COX6B1 MRPS12 PPP1CA ARFGAP2 IDH3B GPX4 CYC1 ARHGDIA SOD1 POLR2I AP1B1 COX4I1 PGD ENSA COX8A CAPZB OTUB1 PSMD8 EIF3C CTDNEP1 DDX49 STOML2 AP3D1 HUWE1 ANP32B GNAI2 MAP2K2 HNRNPAB PSMB4 PDAP1 PSMB6 RAN DNPEP CALR DDOST WBP2 SLC4A2 SMARCD2 COPE UBE2L3 PLOD3 RXRA UBE2I PCMT1 POLR2L LASP1 P4HB GNAS DCTN2 SEPHS2 COPS6 HNRNPUL1 IMPDH1 LYPLA2 LDHA TRAPPC3 ATP6V0C RALY COX6A1 SNRPB SDHA DAZAP2 CTBP1 GNB2 PSMB1 UBA1 RHEB ARF3 NDUFA2 EEF1D up
## GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_YOUNG_DN 0.0034965 0.0160999 0.6190736 3.238248 0 187 RBBP8 MYL6B MCM2 MCM5 CDC45 CDK2AP1 TK1 FEN1 GINS3 CENPM POLA2 FAH CCL17 FANCG ESPL1 CHAF1A TALDO1 LIG1 PCK2 TUBA1B PGAM1 TIMM13 SAC3D1 MCM7 LMNB2 ACOT7 RAD54L TYMP FIBP UMPS ZNF282 TXLNA PPCDC KIF2C NCAPG2 ALDH2 RAD51 KIF4A MCM4 TMEM140 RACGAP1 CDC20 MRPL20 KIF20A NME1 TUBA1C DTYMK CCNB1 AURKB CCDC51 KIF18B MKI67 TPX2 NCAPH BIRC5 YWHAH TUBG1 CDCA8 TMEM106C CDC25C STIP1 PTPN7 MCM10 HMBS RFC4 TUBB6 IMMT KIF11 DCTPP1 FANCA SPAG5 GINS2 STMN1 BLM GALE CCNE1 TYMS IFI30 THOC6 SPATA5L1 CCNB2 CEP55 BRCA1 KIF23 CKAP5 DNAJB6 RRM2 DUT UBE2C VDR CENPA DTL TTI2 NCAPG WDR77 ASPM RAD51D PFAS IL2RA HMMR SLC43A3 TRIP13 TOP2A TXN CENPE NUSAP1 HJURP BATF SRSF1 PXMP2 SLC6A12 TJP2 PALB2 IL12RB2 ALAS1 CKS2 BATF3 up
## MODULE_54 0.0035971 0.0160999 0.5931079 3.226820 0 241 CDKN2C UNG MCM2 MCM5 HMGB2 RANBP1 CDC45 TIMELESS TMEM40 NUDT1 GPN2 FEN1 SLC16A3 PKMYT1 TACC3 POLD1 RFC5 PFKP ORC1 CHAF1A PLK1 HMGA1 NCAPD2 POLQ CHEK1 CDCA5 MCM7 MT1H ATF5 LMNB2 LMNB1 NEIL3 RAD54L MCM3 MCM6 CMYA5 FXYD7 PSRC1 KIF2C PTTG1 SHCBP1 RAD51 UBE2S ASF1B CHAF1B MCM4 CDC20 HUWE1 SNRPF NME1 MTHFD2 RRM1 KNTC1 RECQL4 CCNF FOXM1 ZC3HC1 TROAP DTYMK CCNB1 CCNA2 AURKB APEX2 ATAD2 CDC6 MKI67 LRP8 TPX2 TUBA4A NCAPH PRDX1 BIRC5 TMEM106C CDC25C BUB1 TOPBP1 RFC4 E2F1 KIF11 RCC1 NEK2 WIZ SNRPB SPAG5 CCT5 GINS2 MYBL2 ZWINT PRIM1 BLM PRR11 TYMS SLC7A7 IFI30 DDX11 CCNB2 HBB MAPK13 CEP55 PBK TNFRSF12A KIF23 OAS3 GMNN HOXC10 MB MTFR2 SMC4 RRM2 UBE2C AHCY UBE2T CENPA BUB1B PLK4 ASPM GINS1 FAM83D HMMR TRIP13 TOP2A CENPE NUSAP1 DLGAP5 PHF5A ANLN HJURP CDK4 SMC2 SLC7A5 AURKA WDR5 MELK DEPDC1B TTK APOC2 GGT1 ARHGAP11A CENPF PIR ECT2 CKS2 KIF14 PRDX4 CTNNBIP1 PNP ELOVL6 PCNA PMAIP1 MAD2L1 PLIN2 NDC80 up
## MORF_UBE2I 0.0035211 0.0160999 0.5985819 3.220820 0 219 SRSF9 HNRNPM FBL UBC AP2M1 EIF3K TBCB NUDT1 OAZ1 COX5B CFL1 MRPL23 BANF1 NDUFS3 CNBP CHD4 NGDN GANAB CSK SDR39U1 PPP2R1A HNRNPA1 SART1 PARK7 TUBA1B FAU CCT7 COX6B1 ZNF384 POLR2A ARFGAP2 IDH3B PTMA ZFPL1 NONO CYC1 POLR2I COX4I1 NAP1L4 COX8A OTUB1 PSMD8 TRIM28 CTDNEP1 DDX49 UBB HUWE1 ANP32B HNRNPAB RPS12 PDAP1 PSMB3 RAN LSM7 UQCRH EIF3I RPL13 DHX38 UBE2L3 UBN1 ANAPC5 UBE2I PCMT1 KHDRBS1 HGS GNAS EIF3D CS RPL19 SNRNP70 CNPPD1 COPS6 HNRNPUL1 AATF LYPLA2 LDHA NCL DEK RALY COX6A1 IK SNRPB TUFM DAZAP2 CTBP1 SET RPLP2 PTBP1 GNB2 YBX1 EIF6 ATF4 PSMB1 UBA1 EEF1D FUS RPL22 EIF3M RPL18 BRD8 PSMB7 RPS24 HDGF XRCC6 ILF3 SNRNP200 CDV3 ATP6V1F EEF2 RPS6 UBA2 COX7C OXA1L MRPL9 TARDBP ILF2 NPM1 RPL18A RPL11 NACA KXD1 POLE3 PPIA CANX PUF60 HSP90AB1 EIF4A1 PABPC1 SUMO3 HSPD1 RHOA up
## GSE36476_CTRL_VS_TSST_ACT_72H_MEMORY_CD4_TCELL_OLD_DN 0.0034722 0.0160999 0.6177182 3.211142 0 181 RBBP8 UNG MYL6B COMMD4 MCM2 KEAP1 MCM5 TIMELESS CDK2AP1 MRPL11 EMC9 TK1 TIMM8B NUDT1 FEN1 SNRNP25 CENPM FAH FADD FANCG ESPL1 PSMD2 MFSD5 HMGN2 FAM50B TUBA1B PGAM1 MIS18A MCM7 ACOT7 CYC1 PCCB NAP1L4 NCAPG2 RAD51 KIF4A MCM4 EBNA1BP2 RACGAP1 SNUPN CDC20 RNASEH2A KIF20A PSMB5 NME1 TUBA1C GNPDA1 SMCO4 HNRNPAB FOXM1 DPP3 CCNB1 CCNA2 GSTO1 CORO1C AURKB CCDC51 CDC6 MKI67 TPX2 OIP5 NUP93 FANCE SEPHS2 NCAPH TUBG1 TMEM106C MCM10 RFC4 KIF11 BDH1 SPAG5 GINS2 ZWINT FANCI STMN1 BLM CCNE1 TYMS CCNB2 NDUFS2 CEP55 KIF23 CKAP5 RRM2 UBE2C VDR CENPA DTL NCAPG RAB33A CSTF2 BUB1B PLK4 ASPM RAD51D MED8 MRPL18 IL2RA HMMR SLC43A3 TRIP13 TOP2A NUSAP1 DLGAP5 HJURP CDK4 SMC2 AURKA SRSF1 MELK GBP2 MTHFD1 GOT1 TMPO CENPF HAUS4 ALAS1 PSMB2 TUBB2B up
## MORF_ANP32B 0.0034843 0.0160999 0.6162297 3.206870 0 183 SRSF9 FBL COMMD4 AP2M1 HMGB2 EIF3K NUDT1 NDUFA1 COX5B BANF1 NDUFS3 CNBP NDUFV1 CALM3 CHD4 GANAB PPP2R1A HNRNPA1 SART1 SF3B2 URM1 PARK7 FAU CCT7 ERP29 COX6B1 PPP1CA MCM7 NONO CYC1 SOD1 TATDN2 PPM1G COX4I1 SNRPA PSMD8 TRIM28 EIF3C VDAC2 DDX49 HDAC1 ANP32B HNRNPAB RPS12 PSMB4 PDAP1 RAN DDOST LSM7 UQCRH SMARCD2 COPE UBE2L3 AURKB SNRPD2 ANAPC5 UBE2I PCMT1 KHDRBS1 EIF3G GNAS HADHA COPS6 HNRNPUL1 SF3A2 NCL DEK RALY COX6A1 SNRPB SDHA TUFM DAZAP2 CTBP1 SET RPLP2 PTBP1 RAD23A GNB2 YBX1 PSMB1 EEF1D FUS EIF3M RPL18 PSMB7 EIF4B RPS24 HDGF XRCC6 ILF3 SNRNP200 MTDH EEF2 RPS6 UBA2 COX7C MRPL9 TARDBP PSMC1 NPM1 RPL36AL NACA KXD1 POLE3 CANX PUF60 HSP90AB1 RSL1D1 EIF4A1 PABPC1 SUMO3 HSPD1 up
## CROONQUIST_IL6_DEPRIVATION_DN 0.0029326 0.0160999 0.6863885 3.181766 0 91 MCM2 HMGB2 CDC45 TK1 GALK1 POLD1 CHAF1A GMPS PLK1 LIG1 HMGA1 CHEK1 MCM7 KIF22 GPX4 MCM3 KIF2C PTTG1 MCM4 SBNO2 CDC20 NASP KNTC1 CCNF FOXM1 DTYMK CCNB1 CCNA2 TRAIP AURKB CDC6 MKI67 TPX2 OIP5 NCAPH CDC25A BUB1 KIF11 SPAG5 MYBL2 ZWINT FANCI STMN1 GALE TYMS CCNB2 BRCA1 SMC4 RRM2 DUT UBE2C CENPA STIL BUB1B PLK4 GINS1 RRP12 HMMR TRIP13 TOP2A CENPE SMC2 AURKA up
## MORF_BUB3 0.0036232 0.0160999 0.5827974 3.179977 0 243 SRSF9 HNRNPM FBL MCM2 MCM5 ANP32A EIF3K NUDT1 FEN1 SSRP1 NDUFS3 POLA2 THOP1 NDUFV1 CALM3 TMED9 GANAB ESPL1 DNMT1 CSK DNAJC9 PPP2R1A SLBP CHAF1A GMPS UQCRC1 SF3B2 RUVBL2 PARK7 CCT7 ERP29 KHSRP MCM7 LMNB2 NONO CYC1 MCM3 MCM6 SOD1 PPM1G POLR2I FIBP SEC24C NDUFC1 CAD SNRPA LSM4 UBE2S SLC1A5 PSMD8 TRIM28 RANGAP1 CTDNEP1 VDAC2 CLPP DDX49 HDAC1 ANP32B SAFB NASP NUDC DGUOK MAP2K2 RRM1 HNRNPAB RAN DDOST LSM7 UQCRH EIF3I UBE2L3 AURKB ANAPC5 KHDRBS1 NDUFS5 HADHA CS NCBP2 HNRNPUL1 AATF BUB1 IMPDH1 SF3A2 HAX1 TRAPPC3 NCL RFC4 IMMT AFG3L2 DEK ACLY GNB1 SDHA CCT5 TUFM SET ZWINT STMN1 RAD23A TYMS NDUFS2 RHEB FUS BRD8 DUT PSMB7 PDIA6 SRM RPA2 PTDSS1 XRCC6 ILF3 TXNL4A SNRNP200 MTDH HSPA9 CDK2 UBA2 MRPL9 MDH1 TARDBP ILF2 DNAJC11 EDC4 SDHB CHERP KXD1 SRSF1 PTPN11 POLE3 up
## MORF_MAP2K2 0.0033113 0.0160999 0.6630411 3.174185 0 117 GPI SRSF9 AP2S1 SLC3A2 AP2M1 RPN1 DGKZ EIF3K COX5B BANF1 NDUFS3 NDUFV1 TMED9 GANAB PPP2R1A SF3B2 RUVBL2 TBL3 PARK7 CCT7 ERP29 IDH3B GPX4 NONO CYC1 SOD1 PPM1G POLR2I FIBP NDUFC1 SNRPA LSM4 COX8A UBE2S PSMD8 TRIM28 RANGAP1 CTDNEP1 VDAC2 DDX49 AP3D1 MAP2K2 HNRNPAB DDOST SLC4A2 EIF3I COPE ANAPC5 PCMT1 KHDRBS1 NDUFS5 HADHA DCTN2 CS HNRNPUL1 IMPDH1 HAX1 TRAPPC3 AFG3L2 GNB1 SDHA CCT5 TUFM SET RAD23A GNB2 up
## KANG_DOXORUBICIN_RESISTANCE_UP 0.0025641 0.0160999 0.7676460 3.161897 0 51 HMGB2 ABCC1 TK1 CENPM POLA2 PLK1 PRC1 POLQ LMNB1 NCAPG2 KIF4A ASF1B MCM4 CDC20 DSCC1 RRM1 FOXM1 DTYMK ATAD2 CDC6 MKI67 TPX2 OIP5 BIRC5 CDCA8 BUB1 RFC4 ZWINT FANCI TYMS PBK RAD51AP1 RRM2 CENPA NCAPG BUB1B PLK4 ASPM GINS1 HMMR TOP2A NUSAP1 HJURP AURKA up
## GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_OLD_DN 0.0035211 0.0160999 0.6069118 3.159202 0 186 UNG MYL6B MCM2 KEAP1 RANBP1 CDK2AP1 MRPL11 EMC9 TK1 NUDT1 FEN1 GINS3 GAPDH CENPM ATOX1 FAH MRPL12 FANCG RFC5 ESPL1 PSMD2 GADD45GIP1 POLR2H TALDO1 PCK2 TUBA1B PGAM1 CHEK1 CD2BP2 MCM7 LMNB2 ACOT7 TYMP CYC1 PPM1G GCLM KIF2C POLR3K NCAPG2 ALDH2 RAD51 KIF4A TNS3 MCM4 EBNA1BP2 RACGAP1 SNUPN RNASEH2A NUDC KIF20A PSMB5 NME1 TUBA1C CSTA DPP3 PSMB6 CCNB1 GSTO1 AURKB PHB CDC6 TPX2 LRRC42 SEPHS2 NCAPH TUBG1 TMEM106C CDC25A NUP37 MSRB2 STIP1 MCM10 RFC4 TUBB6 KIF11 BDH1 DCTPP1 SPAG5 GINS2 ZWINT FANCI STMN1 PRIM1 BLM TYMS CCNB2 CEP55 KIF15 CKAP5 RAD51AP1 RRM2 VDR CENPA DTL NCAPG CSTF2 BUB1B ASPM MRPL18 IL2RA HMMR SLC43A3 TRIP13 TRAP1 TOP2A WDR76 DLGAP5 HJURP CDK4 SMC2 AURKA SLC6A12 MELK MTHFD1 ANPEP TMPO CENPF ALAS1 CKS2 up
## GNF2_PCNA 0.0026954 0.0160999 0.7246420 3.158720 0 65 MCM2 MCM5 HMGB2 FEN1 ESPL1 DNAJC9 SLBP PRC1 MCM7 RAD54L MCM3 MCM6 SHCBP1 MCM4 RACGAP1 CDC20 RRM1 HNRNPAB FOXM1 CCNA2 KIF18B MKI67 TPX2 PA2G4 BIRC5 CDCA8 RFC4 KIF11 GINS2 MYBL2 ZWINT FANCI PRIM1 TYMS CCNB2 KIF15 GMNN SMC4 RAD51AP1 RRM2 DTL BUB1B PLK4 ASPM GINS1 HMMR TOP2A PAXIP1 CENPE NUSAP1 DLGAP5 SMC2 AURKA MELK TTK TMPO CENPF CKS2 up
## GSE3337_CTRL_VS_16H_IFNG_IN_CD8POS_DC_DN 0.0034722 0.0160999 0.6079605 3.157703 0 180 FRMD8 MCM2 TRIM21 UBE2L6 TMEM160 PSME2 FKBP8 PSME1 TOMM40 POU6F1 POLA2 EMC10 NDUFV1 CDT1 CAPN1 OSBPL5 CUEDC2 NUP62 PTK2B ADRM1 NAA40 GGA1 BCKDK TANGO2 UHRF1 SMARCB1 CAPNS1 MCM7 OGFR SMAGP PML TSPO SIVA1 MNT RNF19B ABHD8 CPOX PSMB10 SERTAD1 MFNG NOC4L RCC2 CDC20 KANSL2 GPS1 ECE1 TAF1C RNASEH2A ARPC5L UNC119 PDAP1 PSMD4 FAM110A RAN IL18BP UPP1 BST1 PLOD3 SLCO3A1 POLR2L LPP-AS2 PQBP1 AP1S1 HIP1R LYPLA2 NUP85 ABR PIM1 BCL7C HCLS1 HSD3B7 UBA7 RAD23B DVL1 LYSMD1 CHMP1B CCND3 CD37 SOCS1 MAP4K1 PFKFB3 FUS IRF1 INPP5B EGLN2 CASP9 CXCR2 IL12RB1 KIF1B TFIP11 STIL GBP7 C3 NOTCH1 NAA38 PSMC3IP POLDIP3 CDK2AP2 EXTL3 GLIPR2 CYFIP2 GBP2 CXCR3 TNFAIP2 PAFAH1B3 BUD31 SF3B3 up
## GNF2_CCNA2 0.0026954 0.0160999 0.7215419 3.145207 0 65 MCM2 HMGB2 FEN1 ESPL1 PLK1 PRC1 NCAPD2 MCM7 MCM3 MCM6 SHCBP1 KIF4A ASF1B MCM4 RACGAP1 CDC20 KIF20A RRM1 FOXM1 CCNA2 AURKB KIF18B MKI67 TPX2 BIRC5 CDCA8 RFC4 KIF11 GINS2 ZWINT FANCI PRIM1 TYMS CCNB2 EZH2 GMNN SMC4 RAD51AP1 RRM2 UBE2C CENPA NCAPG BUB1B ASPM HMMR TOP2A CENPE NUSAP1 DLGAP5 HJURP SMC2 AURKA MELK TTK TMPO CENPF CKS2 KIF14 up
## chr16p11 0.0032895 0.0160999 0.6504439 3.128941 0 120 NUPR1 ALDOA HIRIP3 SULT1A1 ATP2A1 ARHGAP23P1 SLC7A5P1 STX4 TBC1D10B PYCARD BCKDK CD2BP2 MIR4519 KIF22 CDIPT PPP4C SETD1A FBXL19 PRSS36 RABEP2 SH2B1 ZNF768 ZNF688 ITGAM TAOK2 CORO1A ORAI3 ATXN2L EIF3C MAZ PRR14 FBRS ZNF668 ZNF646 RNF40 ZNF48 SULT1A2 SRCAP PRSS53 KAT8 STX1B ZNF689 ZNF771 MAPK3 SEPHS2 KCTD13 DOC2A SPN ITGAX BCL7C HSD3B7 DCTPP1 MIR3680-2 TUFM HMGN2P41 MYLPF YPEL3 ZNF785 SLC6A10P LAT TRIM72 FUS GDPD3 ITGAL INO80E NPIPB9 C16orf58 HERC2P4 QPRT MVP VKORC1 PHKG2 NFATC2IP ARMC5 PYDC1 TMEM219 IL27 C16orf54 ZNF843 TBX6 COX6A2 TP53TG3D BOLA2B up
## GSE24574_BCL6_HIGH_VS_LOW_TFH_CD4_TCELL_DN 0.0035211 0.0160999 0.5999285 3.122851 0 186 AP2S1 UNG MYL6B MCM5 CDC45 PKM PSMC3 NPC1 STXBP2 MRPL23 VCP BCAT2 ETFB TOMM40 NPM3 PLRG1 SSRP1 FAH FADD THOP1 CDT1 DNMT1 ECI1 ORC1 CHAF1A OSGEP HMGN2 PCK2 COMT CAMK1 AHCYL1 LMNB2 PARP1 RAD54L GCLM TXLNA LGALS1 LAG3 KIF2C CPOX PCCB PGD SNRPA ETHE1 COX8A PCBD1 GZMH MCM4 FKBP2 MFSD10 ENO1 NME1 CCNB1 EIF3I TRIP10 AURKB HNRNPA0 FSCN1 CDC6 MKI67 TPX2 OIP5 PRDX1 TMEM106C IDH2 CDC25C TRAF1 HMGN4 TIAM1 PHGDH LDHA NEK2 COX6A1 NKG7 FANCI DFFA PRIM1 CCNE1 NIPSNAP1 UBA1 SIT1 ATF1 ECHS1 PMVK GBP1 CKAP5 ACTA1 PDIA6 HDGF STAMBP GINS1 LCP2 PFAS BCL2A1 SRD5A1 POLD2 TRAP1 CST7 TOP2A MAPKAPK3 DBI CSTB DLGAP5 up
## WHITEFORD_PEDIATRIC_CANCER_MARKERS 0.0032258 0.0160999 0.6573277 3.122182 0 108 MCM5 CDC45 TK1 EIF4EBP1 NUDT1 GAPDH ESPL1 DNMT1 PRC1 MFN2 CENPN UHRF1 POLQ CDCA5 MCM7 LMNB2 CDCA2 ZNF367 PTTG1 CCDC34 ASF1B MCM4 RCC2 ENO1 NASP RNASEH2A TMEFF1 NME1 RECQL4 DTYMK CCNB1 CCNA2 ADCY3 ATAD2 MKI67 TPX2 MLLT11 RRP1 NCAPH BIRC5 CDCA8 CDC25A BUB1 ZNF300 RFC4 E2F1 KIF11 NEK2 GINS2 MYBL2 ZWINT STMN1 TYMS PSAT1 CCNB2 MND1 PBK SMC4 TWIST1 RRM2 UBE2C MYCN UBE2T CENPA ILF3 MEX3B PLK4 SNRNP200 TOP2A CENPE NUSAP1 ILF2 DLGAP5 CDK4 AURKA MELK TTK EIF4A1 PAFAH1B3 TMPO CENPF CKS2 KIF14 up
## GSE17301_CTRL_VS_48H_ACD3_ACD28_IFNA2_STIM_CD8_TCELL_DN 0.0032895 0.0160999 0.6059012 3.117289 0 169 CDKN2C MRPL28 AAAS HAUS5 HMGB2 ITGA7 TK1 CIC RASSF1 PKMYT1 TOMM40 CENPM SCARB1 DOHH ATP2A1 DBF4B PTGES2 GSS RHOT2 NEFH HMGN2 NAA40 PTDSS2 WDR62 CC2D1A KPTN TUT1 STK11 NCAPH2 EPN1 LRRC61 RAD54L FASTK HDAC7 IQCC POLG PTTG1 CEP164 HSPBP1 ASF1B SLC1A5 MXD3 FKBP4 ZNF646 GTSE1 CEP85 CPPED1 CNPY4 RECQL4 CCNF FOXM1 TROAP MAP2K7 LMF2 TRAIP RTEL1 ZNF500 MICAL3 AKAP3 CLSPN DENND3 SPPL2B E2F1 FGR AKIP1 GPR19 LIMK2 ETV7 MYBL2 SH3GL3 RAG1 CD72 RAC3 HOXA7 TYMS FPGS CCNB2 HOXA10 SLC1A4 BRCA1 RRM2 CAPN10 GFI1 FADS2 TTLL3 SLC25A10 DNMT3B CDK5RAP2 up
Exploring association with clinical variables
label <- ls_preprocessed$pData_rnaseq
ha1 = rowAnnotation(
hclust_com = as.factor(clusters$hclust_com),
canary = as.factor(label$CANARY), #
age = label$Age_at_collection,
gender = as.factor(label$Gender),
race = as.factor(label$Race),
ethnicity = as.factor(label$Ethnicity),
BMI = label$BMI,
smoking = as.factor(label$Smoking_Status),
Pack_Years = label$Pack_Years,
simple_anno_size = unit(0.5, "cm")
)
ha2 = rowAnnotation(
hclust_com = as.factor(clusters$hclust_com),
Age_Started = label$Age_Started,
Age_Quit = label$Age_Quit,
Exposure = as.factor(label$Exposure),
prior_cancer = as.factor(label$Prior_Cancer),
prior_cancer_type = as.factor(label$Prior_Cancer_Type), #*
family_cancer = as.factor(label$Family_History_Cancer_Type),
Chest_CT_Size = label$Chest_CT_Size,
Chest_CT_Location = as.factor(label$Chest_CT_Location),
simple_anno_size = unit(0.5, "cm")
)
ha3 = rowAnnotation(
hclust_com = as.factor(clusters$hclust_com),
Chest_CT_Nodule_Density = as.factor(label$Chest_CT_Nodule_Density), #
CT_Nodule_Margination = as.factor(label$CT_Nodule_Margination),
PET_Lesion = as.factor(label$PET_Lesion),
fev1 = as.numeric(label$FEV1.pred),
eighth_ed_stage = as.factor(label$X8th_ed_path_stage),
simplified_stage = as.factor(label$Stages_simplified),
Path_Nodule_Size_cm = label$Path_Nodule_Size_cm,
life_status = as.factor(label$Living_Status),
simple_anno_size = unit(0.5, "cm")
)
ha4 = rowAnnotation(
hclust_com = as.factor(clusters$hclust_com),
Death_st = as.factor(label$Death_st),
Recurrence_st = as.factor(label$Recurrence_st),
Progression_st = as.factor(label$Progression_st),
DRP_st = as.factor(label$DRP_st),
Hist_pred = as.factor(label$Hist_predominant),
Hist_sec = as.factor(label$Hist_other_patterns),
simple_anno_size = unit(0.5, "cm")
)
Heatmap(corr_pt$r, name = "mat",
heatmap_legend_param = list(color_bar = "continuous"),
row_names_gp = gpar(fontsize = 8),
column_names_gp = gpar(fontsize = 8), right_annotation = ha1)
Heatmap(corr_pt$r, name = "mat",
heatmap_legend_param = list(color_bar = "continuous"),
row_names_gp = gpar(fontsize = 8),
column_names_gp = gpar(fontsize = 8), right_annotation = ha2)
Heatmap(corr_pt$r, name = "mat",
heatmap_legend_param = list(color_bar = "continuous"),
row_names_gp = gpar(fontsize = 8),
column_names_gp = gpar(fontsize = 8), right_annotation = ha3)
Heatmap(corr_pt$r, name = "mat",
heatmap_legend_param = list(color_bar = "continuous"),
row_names_gp = gpar(fontsize = 8),
column_names_gp = gpar(fontsize = 8), right_annotation = ha4)